Family Search for PF15923 (DUF4745)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

PF15923 hits 2 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

GRRE1_HUMAN / O15063 Granule associated Rac and RHOG effector protein 1; GARRE1 from Homo sapiens (Human) (see 2 papers)
NP_055501 granule associated Rac and RHOG effector protein 1 from Homo sapiens
Aligns to 59:187 / 1070 (12.1%), covers 99.2% of PF15923, 182.4 bits

• function: Acts as an effector of RAC1 (PubMed:31871319). Associates with CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation (PubMed:29395067). May also play a role in miRNA silencing machinery (PubMed:29395067).
  subunit: Interacts with AGO2 and TNRC6A.
• Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  Rose, Molecular medicine (Cambridge, Mass.)
  • GeneRIF: Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
• Proteomics/phosphoproteomics of left ventricular biopsies from patients with surgical coronary revascularization and pigs with coronary occlusion/reperfusion: remote ischemic preconditioning.
  Gedik, Scientific reports 2017
  • “...supervillin 1091; 961 O95425 5.14 0.0054 synaptopodin 2-like protein 939 Q9H987 3.27 0.0011 synemin 738 O15063 7.83 0.0008 synemin 580 O15064 6.23 0.0007 synemin 1250 O15065 6.08 0.0015 synemin 873 O15066 3.73 0.0029 transforming acidic coiled-coil-containing protein 2 1594 O95359 4.72 0.0069 transforming acidic coiled-coil-containing protein...”

F1M037 Granule associated Rac and RHOG effector 1 from Rattus norvegicus
Aligns to 59:194 / 991 (13.7%), covers 97.7% of PF15923, 164.2 bits

• Serum Proteomic Profiling Analysis of Rats Chronically Exposed to Arsenic.
  Zhang, Medical science monitor : international medical journal of experimental and clinical research 2019
  • “...0.571 0.534 A0A023IKI3 Proteasome subunit beta type Psmb8 4.35 1 30.6 7.78 0.663 0.741 0.724 F1M037 Protein RGD1308428 Snx1 1.23 1 115.6 7.34 0.769 0.633 0.546 Q4FZY2 Protein Sirt6 Sirt6 3.03 1 36.3 8.44 0.773 0.593 0.524 D4A6Q6 Protein Ino80 Ino80 1.28 1 176.5 9.33 0.809...”

Or search for genetic data about PF15923 in the Fitness Browser