Family Search for PF15997 (DUF4772)

PF15997 hits 3 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

NP_950194 zinc finger protein 395 from Mus musculus
Aligns to 4:110 / 508 (21.1%), covers 100.0% of PF15997, 120.2 bits

• Cloning and characterization of a novel MyoD enhancer-binding factor.
  Yamamoto, Mechanisms of development
  • GeneRIF: Highly related cDNAs Pbf and Gig1 interact with required element MyoD core enhancer; they represents a new family of DNA binding proteins that may be components of transciptional pathways that regulate a number of developmental and physiologic processes.

ZN395_HUMAN / Q9H8N7 Zinc finger protein 395; HD-regulating factor 2; HDRF-2; Huntington disease gene regulatory region-binding protein 2; HD gene regulatory region-binding protein 2; HDBP-2; Papillomavirus regulatory factor 1; PRF-1; Papillomavirus-binding factor from Homo sapiens (Human) (see 2 papers)
NP_061130 zinc finger protein 395 from Homo sapiens
Aligns to 7:109 / 513 (20.1%), covers 100.0% of PF15997, 118.3 bits

• function: Plays a role in papillomavirus genes transcription
  subunit: Interacts with repression-mediating E2 binding site P2 of human papillomavirus type 8 (HPV8)
• DNA Damage Regulates Translation through β-TRCP Targeting of CReP.
  Loveless, PLoS genetics 2015
  • “...yes stable stable DTTFLLD ATF-4 P18848 11 9 19 CDC25A P30304 11 7 14 ZNF395 Q9H8N7 9 6 11 yes yes DSGSSTTS ZNF704 Q6ZNC4 7 3 9 yes partial partial DDGIDEAE/SDGEED PDCD4 Q53EL6 5 4 4 bHLHE40 O14503 5 2 14 yes * CDC25B P30305 3...”
• Human spermatozoa contain multiple targets for protein S-nitrosylation: an alternative mechanism of the modulation of sperm function by nitric oxide?
  Lefièvre, Proteomics 2007
  • “...subfamily C member 1 SMRC1_HUMAN Q92922 123.2 2 2.4 1 Zinc finger protein 395 ZN395_HUMAN Q9H8N7 55.7 1 1.6 1 Zinc finger protein 512 ZN512_HUMAN Q96ME7 65.7 3 5.6 1 Zinc finger protein 696 ZN696_HUMAN Q9H7X3 41.7 2 5.9 1 Zinc finger protein 740 ZN740_HUMAN Q8NDX6...”
• Downregulation of ZNF395 Drives Progression of Pancreatic Ductal Adenocarcinoma through Enhancement of Growth Potential.
  Kurogi, Pathobiology : journal of immunopathology, molecular and cellular biology 2021 (PubMed)
  • GeneRIF: Downregulation of ZNF395 Drives Progression of Pancreatic Ductal Adenocarcinoma through Enhancement of Growth Potential.
• ZNF395 Is an Activator of a Subset of IFN-Stimulated Genes.
  Schroeder, Mediators of inflammation 2017
  • GeneRIF: The transcriptional activation of CXCL10 and CXCL11 by ZNF395 was abolished after inhibition of IKK by BMS-345541, which increased the stability of ZNF395. ZNF395 encodes at least two motifs that mediate the enhanced degradation of ZNF395 in response to IKK activation. Thus, IKK is required for ZNF395-mediated activation of transcription and enhances its turn-over to keep the activity of ZNF395 low.
• VHL Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma.
  Yao, Cancer discovery 2017 (PubMed)
  • GeneRIF: epigenomic profiling of clear cell renal cell carcinoma (ccRCC) establishes a compendium of somatically altered cis-regulatory elements, uncovering new potential targets including ZNF395. Loss of VHL, a ccRCC signature event, causes pervasive enhancer malfunction, with binding of enhancer-centric HIF2a and recruitment of histone acetyltransferase p300 at preexisting lineage-specific promoter-enhancer complexes
• MiR-525-3p enhances the migration and invasion of liver cancer cells by downregulating ZNF395.
  Pang, PloS one 2014
  • GeneRIF: miR-525-3p promotes liver cancer cell migration and invasion by directly targeting ZNF395.
• Identification of ZNF395 as a novel modulator of adipogenesis.
  Hasegawa, Experimental cell research 2013 (PubMed)
  • GeneRIF: ZNF395 coordinate the transcriptional regulatory pathway with PPARG2, which may be necessary for the genesis of adipocytes.
• Emerging roles of zinc finger proteins in regulating adipogenesis.
  Wei, Cellular and molecular life sciences : CMLS 2013
  • GeneRIF: Studies indicate that ZNF395 was strongly expressed in adipocytes, and suggest a role for ZNF395 as a modulator of adipogenesis.
• The hypoxia-inducible transcription factor ZNF395 is controlled by IĸB kinase-signaling and activates genes involved in the innate immune response and cancer.
  Jordanovski, PloS one 2013
  • GeneRIF: IkBalpha kinase (IKK)-signaling is necessary to allow ZNF395 to activate transcription and simultaneously enhances its proteolytic degradation.
• Scythe/BAT3 regulates apoptotic cell death induced by papillomavirus binding factor in human osteosarcoma.
  Tsukahara, Cancer science 2009
  • GeneRIF: colocalization of PBF and Scythe/BAT3 in the nucleus might be an important factor for survival of osteosarcoma cells.
• More

LOC122271089 zinc finger protein 395-like from Parasteatoda tepidariorum
Aligns to 5:107 / 229 (45.0%), covers 99.1% of PF15997, 101.9 bits

• Single-cell RNA sequencing of mid-to-late stage spider embryos: new insights into spider development
  Medina-Jiménez, BMC genomics 2024
  • “...are neurotactin ( nrt ) (LOC107441543), magu (LOC107453771), zinc finger protein 395-like ( zfp395-like ) (LOC122271089), fasciclin -2 ( fas2 ) (LOC107436358), noggin ( nog ) (LOC107444265) and otopetrin-2-like ( otop2 ) (LOC107451015). In Drosophila, nrt is involved in morphogenic movements and is expressed in dynamic...”

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