Family Search for PF15997 (DUF4772)

PF15997 hits 4 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

NP_950194 zinc finger protein 395 from Mus musculus
Aligns to 4:110 / 508 (21.1%), covers 100.0% of PF15997, 120.2 bits

• Cloning and characterization of a novel MyoD enhancer-binding factor.
  Yamamoto, Mechanisms of development
  • GeneRIF: Highly related cDNAs Pbf and Gig1 interact with required element MyoD core enhancer; they represents a new family of DNA binding proteins that may be components of transciptional pathways that regulate a number of developmental and physiologic processes.

ZN395_HUMAN / Q9H8N7 Zinc finger protein 395; HD-regulating factor 2; HDRF-2; Huntington disease gene regulatory region-binding protein 2; HD gene regulatory region-binding protein 2; HDBP-2; Papillomavirus regulatory factor 1; PRF-1; Papillomavirus-binding factor from Homo sapiens (Human) (see 2 papers)
NP_061130 zinc finger protein 395 from Homo sapiens
Aligns to 7:109 / 513 (20.1%), covers 100.0% of PF15997, 118.3 bits

• function: Plays a role in papillomavirus genes transcription
  subunit: Interacts with repression-mediating E2 binding site P2 of human papillomavirus type 8 (HPV8)
• Downregulation of ZNF395 Drives Progression of Pancreatic Ductal Adenocarcinoma through Enhancement of Growth Potential.
  Kurogi, Pathobiology : journal of immunopathology, molecular and cellular biology 2021 (PubMed)
  • GeneRIF: Downregulation of ZNF395 Drives Progression of Pancreatic Ductal Adenocarcinoma through Enhancement of Growth Potential.
• ZNF395 Is an Activator of a Subset of IFN-Stimulated Genes.
  Schroeder, Mediators of inflammation 2017
  • GeneRIF: The transcriptional activation of CXCL10 and CXCL11 by ZNF395 was abolished after inhibition of IKK by BMS-345541, which increased the stability of ZNF395. ZNF395 encodes at least two motifs that mediate the enhanced degradation of ZNF395 in response to IKK activation. Thus, IKK is required for ZNF395-mediated activation of transcription and enhances its turn-over to keep the activity of ZNF395 low.
• VHL Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma.
  Yao, Cancer discovery 2017 (PubMed)
  • GeneRIF: epigenomic profiling of clear cell renal cell carcinoma (ccRCC) establishes a compendium of somatically altered cis-regulatory elements, uncovering new potential targets including ZNF395. Loss of VHL, a ccRCC signature event, causes pervasive enhancer malfunction, with binding of enhancer-centric HIF2a and recruitment of histone acetyltransferase p300 at preexisting lineage-specific promoter-enhancer complexes
• MiR-525-3p enhances the migration and invasion of liver cancer cells by downregulating ZNF395.
  Pang, PloS one 2014
  • GeneRIF: miR-525-3p promotes liver cancer cell migration and invasion by directly targeting ZNF395.
• Identification of ZNF395 as a novel modulator of adipogenesis.
  Hasegawa, Experimental cell research 2013 (PubMed)
  • GeneRIF: ZNF395 coordinate the transcriptional regulatory pathway with PPARG2, which may be necessary for the genesis of adipocytes.
• Emerging roles of zinc finger proteins in regulating adipogenesis.
  Wei, Cellular and molecular life sciences : CMLS 2013
  • GeneRIF: Studies indicate that ZNF395 was strongly expressed in adipocytes, and suggest a role for ZNF395 as a modulator of adipogenesis.
• The hypoxia-inducible transcription factor ZNF395 is controlled by IĸB kinase-signaling and activates genes involved in the innate immune response and cancer.
  Jordanovski, PloS one 2013
  • GeneRIF: IkBalpha kinase (IKK)-signaling is necessary to allow ZNF395 to activate transcription and simultaneously enhances its proteolytic degradation.
• Scythe/BAT3 regulates apoptotic cell death induced by papillomavirus binding factor in human osteosarcoma.
  Tsukahara, Cancer science 2009
  • GeneRIF: colocalization of PBF and Scythe/BAT3 in the nucleus might be an important factor for survival of osteosarcoma cells.
• More
• DNA Damage Regulates Translation through β-TRCP Targeting of CReP.
  Loveless, PLoS genetics 2015
  • “...yes stable stable DTTFLLD ATF-4 P18848 11 9 19 CDC25A P30304 11 7 14 ZNF395 Q9H8N7 9 6 11 yes yes DSGSSTTS ZNF704 Q6ZNC4 7 3 9 yes partial partial DDGIDEAE/SDGEED PDCD4 Q53EL6 5 4 4 bHLHE40 O14503 5 2 14 yes * CDC25B P30305 3...”
• Human spermatozoa contain multiple targets for protein S-nitrosylation: an alternative mechanism of the modulation of sperm function by nitric oxide?
  Lefièvre, Proteomics 2007
  • “...subfamily C member 1 SMRC1_HUMAN Q92922 123.2 2 2.4 1 Zinc finger protein 395 ZN395_HUMAN Q9H8N7 55.7 1 1.6 1 Zinc finger protein 512 ZN512_HUMAN Q96ME7 65.7 3 5.6 1 Zinc finger protein 696 ZN696_HUMAN Q9H7X3 41.7 2 5.9 1 Zinc finger protein 740 ZN740_HUMAN Q8NDX6...”

LOC122271089 zinc finger protein 395-like from Parasteatoda tepidariorum
Aligns to 5:107 / 229 (45.0%), covers 99.1% of PF15997, 101.9 bits

• Single-cell RNA sequencing of mid-to-late stage spider embryos: new insights into spider development
  Medina-Jiménez, BMC genomics 2024
  • “...are neurotactin ( nrt ) (LOC107441543), magu (LOC107453771), zinc finger protein 395-like ( zfp395-like ) (LOC122271089), fasciclin -2 ( fas2 ) (LOC107436358), noggin ( nog ) (LOC107444265) and otopetrin-2-like ( otop2 ) (LOC107451015). In Drosophila, nrt is involved in morphogenic movements and is expressed in dynamic...”

LOC101845787 zinc finger protein 704 from Aplysia californica
Aligns to 5:111 / 552 (19.4%), covers 98.2% of PF15997, 82.4 bits

• Single-neuron analysis of aging-associated changes in learning reveals impairments in transcriptional plasticity
  Badal, Aging cell 2024
  • “...(LOC101847706, LOC101847009), zinc finger protein 16, 271, 493, 628, 704, 708 (LOC101848424, LOC101851507, LOC101852427, LOC118477209, LOC101845787, LOC101860932, LOC101857232), transcription factor 20, MafF, Sox10, Sp3, TFIIIB (LOC101853672, LOC101851728, LOC101847270, LOC101863331, LOC101855811). Interestingly we identified several epigenetic regulation related genes such as histone acetyltransferase KAT2A isoform (LOC101856257), histonelysine...”

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