Family Search for PF16269 (DUF4922)

PF16269.5 hits 2 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

Tanf_08355 DUF4922 domain-containing protein from Tannerella forsythia
Aligns to 111:300 / 310 (61.3%), covers 99.5% of PF16269, 237.4 bits

• Regulation and Molecular Basis of Environmental Muropeptide Uptake and Utilization in Fastidious Oral Anaerobe Tannerella forsythia
  Ruscitto, Frontiers in microbiology 2017
  • “...primer sets spanning adjacent genes (fragments a-j). Tanf_08345, xanthane lyase; Tanf_08350 ( gtf ), glycosyltransferase; Tanf_08355 ( gtf ), glycosyltransferase; Tanf_08360 ( lytB ), amidase enhancer precursor; Tanf_08365 ( ampG ), muropeptide permease; Tanf_08370 ( ybbC ), conserved hypothetical protein. (B) PCR products were separated on...”

GGAP2_ARATH / Q9FLP9 GDP-L-galactose phosphorylase 2; Protein VITAMIN C DEFECTIVE 5; EC 2.7.7.69 from Arabidopsis thaliana (Mouse-ear cress) (see 5 papers)
Q9FLP9 GDP-L-galactose phosphorylase (EC 2.7.7.69) from Arabidopsis thaliana (see 2 papers)
VTC5 / Q9FLP9 GDP-L-galactose phosphorylase (EC 2.7.7.69) from Arabidopsis thaliana (see 3 papers)
AT5G55120 VTC5 (VITAMIN C DEFECTIVE 5); GDP-D-glucose phosphorylase/ galactose-1-phosphate guanylyltransferase (GDP)/ quercetin 4'-O-glucosyltransferase (RefSeq) from Arabidopsis thaliana
NP_200323 GDP-L-galactose phosphorylase VITAMIN C DEFECTIVE 5 (VTC5) from Arabidopsis thaliana
Aligns to 197:382 / 431 (43.2%), covers 81.9% of PF16269, 34.8 bits

• function: Catalyzes a reaction of the Smirnoff-Wheeler pathway, the major route to ascorbate biosynthesis in plants. Acts as a phosphorylase rather than as a transferase. Uses preferentially GDP-L- galactose and GDP-D-glucose as substrates. Lower activity with GDP-L- fucose, very low activity with GDP-D-mannose, and no activity with UDP- D-glucose, UDP-D-galactose or ADP-D-glucose. Highly specific for inorganic phosphate as the guanylyl acceptor.
  catalytic activity: GDP-beta-L-galactose + phosphate = beta-L-galactose 1- phosphate + GDP + H(+) (RHEA:27698)
  subunit: Interacts with TLP1.
  disruption phenotype: No visible phenotype and slightly decreased ascorbate levels; due to the partial redundancy with VTC2. Vtc2 and vtc5 double mutants show growth arrest immediately upon germination and are not viable.
• Molecular evolution of GDP-L-galactose phosphorylase, a key regulatory gene in plant ascorbate biosynthesis
  Tao, AoB PLANTS 2020
  • “...well studied. Therefore, the A. thaliana GGP amino acid sequences of VTC2 (At4g26850) and VTC5 (At5g55120), which were downloaded from the TAIR database ( https://www.arabidopsis.org/ ), were used as queries to carry out BLASTP searches against the databases of Phytozome v12.1 and NCBI with default algorithm...”
• GDP-D-mannose epimerase regulates male gametophyte development, plant growth and leaf senescence in Arabidopsis
  Qi, Scientific reports 2017
  • “...in this article are as follows: GME (AT5G28840), ACTIN2 (AT3G18780), QRT1 (AT5G55590), VTC2 (AT4G26850), VTC5 (AT5G55120), CAB1 (AT1G29930), CAB2 (AT1G29920), RBCS (At1g67090), SAG13 (AT2G29350), SAG21 (AT4G02380) and SEN4 (AT4G30270). Data availability All data generated or analysed during this study are included in this published article and...”
• Redox Changes During the Cell Cycle in the Embryonic Root Meristem of Arabidopsis thaliana
  de, Antioxidants & redox signaling 2017
  • “...the Arabidopsis Genome Initiative or GenBank/EMBL databases under the following accession numbers: VTC2 (At4g26850), VTC5 (At5g55120), CYP82C2 (At4g31970), CENTRIN 2 (At4g37010), GSTU12 (At1g69920), GSTU8 (At3g09270), GLU1 (At3g09270), MYB56 (At5g17800), SDS (At1g14750), CDC7 (At4g16970), CDKB1;2 (At2g38620), GRX-C8 (At5g14070), GRXS9 (At5g01420), SKU5 (At4g38420), UXS6 (At2g28760), PAP2 (At1g66390), UGT72B2...”
• Conservation and Expression Patterns Divergence of Ascorbic Acid d-mannose/l-galactose Pathway Genes in Brassica rapa
  Duan, Frontiers in plant science 2016
  • “...potential FLC target genes have been defined by Deng et al. (2011) , and VTC5 (AT5G55120) is one of the putative FLC targets ( Deng et al., 2011 ). In this study, to verify whether VTC5 interacted with FLC , we detected the expression patterns of...”
• The influence of metal stress on the availability and redox state of ascorbate, and possible interference with its cellular functions
  Bielen, International journal of molecular sciences 2013
  • “...remaining AsA. They identified another Arabidopsis thaliana gene, a homolog of VTC2 , namely VTC5 (At5g55120) encoding a second GLGalpp with similar properties to VTC2, and which is generally expressed at a 1001000-fold lower than VTC2 . The vtc5-1 and vtc5-2 mutants contain approximately 90% of...”
• A temporal precedence based clustering method for gene expression microarray data
  Krishna, BMC bioinformatics 2010
  • “...AT1G27450, AT4G37910, AT2G45030, AT5G50950, AT1G69370 Figure 10 51869 5.5701E-12 2.3450E-9 20/41 Response to stimulus AT5G20850, AT5G55120, AT3G08720, AT4G37680, AT5G26870, AT1G33560, AT2G47180, AT2G05520, AT1G48030, AT4G01060, AT5G37780, AT1G63840, AT2G14580, AT1G58220, AT3G26790, AT3G54320, AT5G10450, AT1G74310, AT5G45340, AT5G40350 Figure 11 9628 1.1048E-5 1.3147E-3 4/7 Response to abiotic stimulus AT5G52310, AT3G17020,...”
• Exploring the impact of wounding and jasmonates on ascorbate metabolism
  Suza, Plant physiology and biochemistry : PPB 2010
  • “...pyrophosphorylase (VTC1, At2g39770), GDP-D-mannose -3 , 5 -epimerase (GME, At5g28840), GDP-L-galactose phosphorylase (VTC2, At4g26850; VTC5, At5g55120), L-galactose-1-phosphate phosphatase (VTC4, At3g02870), L-galactose dehydrogenase (GalDH, At4g33670), L-galactono-1,4-lactone dehydrogenase (GLDH, At4g47930) and myo-inositol oxygenase 1 (MIOX1, At1g14520), MIOX2 (At2g19800), MIOX4 (At4g26260), and MIOX5 (At5g56640). Real-time reverse-transcription PCR Arabidopsis wild...”
• A second GDP-L-galactose phosphorylase in arabidopsis en route to vitamin C. Covalent intermediate and substrate requirements for the conserved reaction
  Linster, The Journal of biological chemistry 2008
  • “...deficiency. Here we show that the Arabidopsis gene At5g55120 encodes an enzyme with high sequence identity to VTC2. Designated VTC5, this enzyme displays...”
  • “...U11937 clone containing the coding sequence of the At5g55120 gene (prepared by the Salk Institute Genomic Analysis Laboratory (18) and provided by the...”
• More
• Characterization of Erysiphe necator-responsive genes in Chinese Wild Vitis quinquangularis
  Gao, International journal of molecular sciences 2012
  • “...protein V. pseudoreticulata ABC86744 5 10 21 UN022 548 GDP- d -glucose phosphorylase A. thaliana NP_200323 2 10 19 UN044 a 562 S -adenosylmethionine synthetase R. communis XP_002512570 4 10 101 UN102 369 ATP-dependent peptidase/ATPase/metallopeptidase A. thaliana NP_564563 3 10 59 UN127 829 Malate dehydrogenase N....”
• A second GDP-L-galactose phosphorylase in arabidopsis en route to vitamin C. Covalent intermediate and substrate requirements for the conserved reaction.
  Linster, The Journal of biological chemistry 2008
  • GeneRIF: Arabidopsis VTC2 and VTC5 proteins are enzymes that guanylylate a conserved active site His residue with GDP-L-galactose, forming L-galactose 1-phosphate for vitamin C synthesis, and regenerate the enzyme with phosphate to form GDP.
• Two genes in Arabidopsis thaliana encoding GDP-L-galactose phosphorylase are required for ascorbate biosynthesis and seedling viability.
  Dowdle, The Plant journal : for cell and molecular biology 2007 (PubMed)
  • GeneRIF: Data show that At5g55120, a homologue of GDP-L-galactose phosphorylase (VTC2), encodes a second GDP-L-galactose phosphorylase with similar properties to VTC2.

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