Family Search for PF16269 (DUF4922)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

Running HMMer for PF16269

PF16269 hits 6 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

APA2_YEAST / P22108 Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase 2; Ap4A phosphorylase 2; ADP-sulfurylase; ATP adenylyltransferase; EC 2.7.7.53; EC 2.7.7.5 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 6 papers)
Aligns to 6:166 / 325 (49.5%), covers 89.0% of PF16269, 31.3 bits

• function: Ap4A phosphorylase catalyzes the phosphorolytic degradation of bis(5'-adenosyl) tetraphosphate (Ap4A) into ADP and ATP. Can also use other Np4N' nucleotides (where N and N' stand for A,C,G or U) as substrates, but prefers A-containing substrates. Cannot catalyze the reverse reaction. Additionally, this enzyme can also catalyze the phosphorolytic degradation of adenosine 5'-phosphosulfate (AMPS) into ADP and sulfate, the reversible exchange reaction between inorganic phosphate and the beta-phosphate of a nucleoside diphosphate (NDP), and the synthesis of Ap4A from AMPS plus ATP.
  catalytic activity: ADP + ATP + H(+) = P(1),P(4)-bis(5'-adenosyl) tetraphosphate + phosphate (RHEA:16577)
  catalytic activity: ADP + H(+) + sulfate = adenosine 5'-phosphosulfate + phosphate (RHEA:16529)
  cofactor: a divalent metal cation
  subunit: Monomer.
  disruption phenotype: Inactivation of both APA1 and APA2 promotes a great increase in the cellular concentration of bis(5'-nuceleosidyl) tetraphosphate nucleotides.

APA1_YEAST / P16550 Protein APA1; EC 2.7.7.53; EC 2.7.7.5 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 10 papers)
Aligns to 79:163 / 321 (26.5%), covers 46.6% of PF16269, 31.2 bits

• function: Ap4A phosphorylase catalyzes the phosphorolytic degradation of bis(5'-adenosyl) tetraphosphate (Ap4A) into ADP and ATP. Can also use other Np4N' nucleotides (where N and N' stand for A,C,G or U) as substrates with equal efficiency. Cannot catalyze the reverse reaction. Additionally, this enzyme can also catalyze the phosphorolytic degradation of adenosine 5'-phosphosulfate (AMPS) into ADP and sulfate, the reversible exchange reaction between inorganic phosphate and the beta-phosphate of a nucleoside diphosphate (NDP), and the synthesis of Ap4A from AMPS plus ATP.
  catalytic activity: ADP + ATP + H(+) = P(1),P(4)-bis(5'-adenosyl) tetraphosphate + phosphate (RHEA:16577)
  catalytic activity: ADP + H(+) + sulfate = adenosine 5'-phosphosulfate + phosphate (RHEA:16529)
  cofactor: a divalent metal cation
  subunit: Monomer.
  disruption phenotype: Inactivation of both APA1 and APA2 promotes a great increase in the cellular concentration of bis(5'-nuceleosidyl) tetraphosphate nucleotides.

Or search for genetic data about PF16269 in the Fitness Browser