Family Search for PF16401 (DUF5009)

PF16401 hits 18 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

BT0446 conserved hypothetical protein from Bacteroides thetaiotaomicron VPI-5482
BT_RS02190 DUF5009 domain-containing protein from Bacteroides thetaiotaomicron VPI-5482
Aligns to 4:263 / 469 (55.4%), covers 100.0% of PF16401, 403.6 bits

• Iron Deficiency Modulates Metabolic Landscape of Bacteroidetes Promoting Its Resilience during Inflammation
  Lewis, Microbiology spectrum 2023
  • “...0.021 BT_RS02165 BT0442 DUF4855 domain-containing protein 6.1 to 2.6 9E-04 to 0.025 BT_RS02190 to 205 BT0446 to 49 DUF5009 domain-containing protein, family 10 glycosylhydrolase, calcineurin-like phosphoesterase C-terminal domain-containing protein, family 10 glycosylhydrolase 7.1 to 2.5 8E-04 to 0 0.154 BT_RS02215 to 30 BT0451 to 54 RagB/SusD...”
• Iron Deficiency Modulates Metabolic Landscape of Bacteroidetes Promoting Its Resilience during Inflammation
  Lewis, Microbiology spectrum 2023
  • “...membr. Protein 2.6 0.021 BT_RS02165 BT0442 DUF4855 domain-containing protein 6.1 to 2.6 9E-04 to 0.025 BT_RS02190 to 205 BT0446 to 49 DUF5009 domain-containing protein, family 10 glycosylhydrolase, calcineurin-like phosphoesterase C-terminal domain-containing protein, family 10 glycosylhydrolase 7.1 to 2.5 8E-04 to 0 0.154 BT_RS02215 to 30 BT0451...”

CD2785 hypothetical protein from Clostridium difficile 630
Aligns to 4:172 / 370 (45.7%), covers 41.2% of PF16401, 41.0 bits

• The structure of the S-layer of Clostridium difficile
  Bradshaw, Journal of cell communication and signaling 2018
  • “...biosynthesis in yellow and biopolymer export in green, other functions are in grey. CD2768 hydrolase, CD2785 membrane protein, CD2788 GtrA-like membrane protein, CD2797 calcium binding adhesin. Terminators predicted by Genome2D (Baerends et al. 2004 ) are shown in red Fig. 3 Putative domain representation of the...”

XP_004928101 heparan-alpha-glucosaminide N-acetyltransferase from Bombyx mori
Aligns to 191:312 / 581 (21.0%), covers 39.6% of PF16401, 37.4 bits

• Pheromone gland transcriptome of the pink bollworm moth, Pectinophora gossypiella: Comparison between a laboratory and field population
  Dou, PloS one 2019
  • “...litura 0 91 FAR8 fatty-acyl CoA reductase ADI82791 Ostrinia nubilalis 40 Acetyltransferase FAT1 heparan-alpha-glucosaminide N-acetyltransferase XP_004928101 Bombyx mori 0 79 FAT2 PREDICTED: heparan-alpha-glucosaminide N-acetyltransferase-like XP_013191695 Amyelois transitella 0 78 FAT3 PREDICTED: 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha-like XP_013195392 Amyelois transitella 4E-168 83 FAT4 lysophospholipid acyltransferase 7-like XP_021192342 Helicoverpa armigera...”

Amuc_0502 putative transmembrane protein from Akkermansia muciniphila ATCC BAA-835
Aligns to 11:177 / 373 (44.8%), covers 39.6% of PF16401, 34.4 bits

• Health and Disease: Akkermansia muciniphila, the Shining Star of the Gut Flora
  Xue, Research (Washington, D.C.) 2023
  • “...involved in mucin degradation are significantly upregulated under mucin conditions [ 40 ]. N-acetylglucosamine transporters Amuc_0502 and Amuc_0516 are the most highly upregulated genes when A. muciniphila is grown on mucin medium. A. muciniphila produces a variety of metabolites such as oligosaccharides and short-chain fatty acids...”
• Genome-Scale Model and Omics Analysis of Metabolic Capacities of Akkermansia muciniphila Reveal a Preferential Mucin-Degrading Lifestyle
  Ottman, Applied and environmental microbiology 2017
  • “...the described conditions. The identified GlcNAc transporters, Amuc_0502 and Amuc_0516, are among the most highly upregulated genes under the mucin condition...”

HU689_06285 transmembrane glucosamine N-acetyltransferase NagX from Shewanella algae
Aligns to 16:192 / 381 (46.5%), covers 58.1% of PF16401, 33.5 bits

• Complete genome sequence of Shewanella algae strain 2NE11, a decolorizing bacterium isolated from industrial effluent in Peru
  Lizárraga, Biotechnology reports (Amsterdam, Netherlands) 2022
  • “...HU689_06255 ), catalysis ( HU689_06275, HU689_06270 ), regulation ( HU689_06250 ), and complementary processes ( HU689_06285, HU689_06280, HU689_06265, HU689_06260 ) due their highly similarity to S. oneidensis MR-1 Nag genes. They have been found in almost all genomes of Shewanella genus and many isolated strains have...”

Sama_0947 transmembrane glucosamine N-acetyltransferase NagX from Shewanella amazonensis SB2B
Aligns to 12:185 / 378 (46.0%), covers 61.2% of PF16401, 32.7 bits

• mutant phenotype: Specifically important for glucosamine utilization. NagX proteins are distantly related to human HGSNAT (uniprot:Q68CP4), which is a transmembrane acetyl-CoA:alpha-glucosaminide N-acetyltransferase.

Echvi_1106 transmembrane glucosamine N-acetyltransferase NagX from Echinicola vietnamensis KMM 6221, DSM 17526
Aligns to 5:106 / 369 (27.6%), covers 38.1% of PF16401, 31.3 bits

• mutant phenotype: Specifically important for glucosamine utilization. NagX proteins are distantly related to human HGSNAT (uniprot:Q68CP4), which is a transmembrane acetyl-CoA:alpha-glucosaminide N-acetyltransferase.

BT3180 conserved hypothetical protein from Bacteroides thetaiotaomicron VPI-5482
Aligns to 11:175 / 376 (43.9%), covers 40.8% of PF16401, 31.1 bits

• Mucus-degrading Bacteroides link carbapenems to aggravated graft-versus-host disease
  Hayase, Cell 2022
  • “...as follows, with the numbers being inclusive (i.e., in the first mutant, genes BT3172 and BT3180 were part of the deletion): BT317280, BT161736 (two tandem PULs removed together), BT37963800, BT30923109, BT075257, BT291223, BT468184, BT463431, BT086567, BT425040 . Culturing of bacteria Mouse-derived BT (MDA-JAX BT001), Enterococcus faecalis...”

8jkvA / Q68CP4 Membrane proteins
Aligns to 164:261 / 527 (18.6%), covers 21.9% of PF16401, 30.5 bits

• Ligand: cholesterol (8jkvA)

Shewana3_3111 transmembrane glucosamine N-acetyltransferase NagX from Shewanella sp. ANA-3
nagX / A0KZW6 D-glucosamine N-acetyltransferase (EC 2.3.1.3) from Shewanella sp. (strain ANA-3) (see paper)
Shewana3_3111 hypothetical protein from Shewanella sp ANA-3
Aligns to 29:209 / 395 (45.8%), covers 64.6% of PF16401, 30.4 bits

• mutant phenotype: Specifically important for glucosamine utilization. NagX proteins are distantly related to human HGSNAT (uniprot:Q68CP4), which is a transmembrane acetyl-CoA:alpha-glucosaminide N-acetyltransferase.
• Filling gaps in bacterial catabolic pathways with computation and high-throughput genetics
  Price, PLoS genetics 2022
  • “...histidine which carries the acetyl group across the membrane is conserved: for instance, His72 of Shewana3_3111 aligns to His297 of HGSNAT (SwissProt Q68CP4). Once NAcGln is formed, it can be transported across the membrane and phosphorylated (such as by NagP and NagK, or by a phosphotransferase...”

M3X793 Heparan-alpha-glucosaminide N-acetyltransferase from Felis catus
Aligns to 298:402 / 669 (15.7%), covers 22.3% of PF16401, 29.4 bits

• A genetic and clinical study of individuals with nonsyndromic retinopathy consequent upon sequence variants in HGSNAT, the gene associated with Sanfilippo C mucopolysaccharidosis.
  Schiff, American journal of medical genetics. Part C, Seminars in medical genetics 2020
  • “...in the human, KZBY75 in the chimp, H9EWF5 in the Rhesus macaque, F1NBK1in the cat, M3X793 in the mouse, Q3UDW8 in the chicken, F1Q893 in the zebrafish, and A0A0A1XN23 in the Melon fruit fly About 4 of the 12 variants have been previously reported in patients...”

NP_084160 heparan-alpha-glucosaminide N-acetyltransferase precursor from Mus musculus
Aligns to 254:358 / 624 (16.8%), covers 21.9% of PF16401, 27.6 bits

• HGSNAT enzyme deficiency results in accumulation of heparan sulfate in podocytes and basement membranes.
  Nagel, Histology and histopathology 2019 (PubMed)
  • GeneRIF: Hgsnat gene inactivation and heparan sulfate toxicity have an effect on the integrity of the renal corpuscle

HGNAT_MOUSE / Q3UDW8 Heparan-alpha-glucosaminide N-acetyltransferase; Transmembrane protein 76; EC 2.3.1.78 from Mus musculus (Mouse) (see 2 papers)
Q3UDW8 heparan-alpha-glucosaminide N-acetyltransferase (EC 2.3.1.78) from Mus musculus (see paper)
Aligns to 286:389 / 656 (15.9%), covers 21.9% of PF16401, 27.4 bits

• function: Lysosomal acetyltransferase that acetylates the non-reducing terminal alpha-glucosamine residue of intralysosomal heparin or heparan sulfate, converting it into a substrate for luminal alpha-N-acetyl glucosaminidase.
  catalytic activity: acetyl-CoA + alpha-D-glucosaminyl-[heparan sulfate](n) = CoA + H(+) + N-acetyl-alpha-D-glucosaminyl-[heparan sulfate](n) (RHEA:15125)
  subunit: Homooligomer. Homooligomerization is necessary for enzyme activity (By similarity).
• A genetic and clinical study of individuals with nonsyndromic retinopathy consequent upon sequence variants in HGSNAT, the gene associated with Sanfilippo C mucopolysaccharidosis.
  Schiff, American journal of medical genetics. Part C, Seminars in medical genetics 2020
  • “...in the chimp, H9EWF5 in the Rhesus macaque, F1NBK1in the cat, M3X793 in the mouse, Q3UDW8 in the chicken, F1Q893 in the zebrafish, and A0A0A1XN23 in the Melon fruit fly About 4 of the 12 variants have been previously reported in patients with MPSIIIC as compound...”

SO_3504 conserved hypothetical protein from Shewanella oneidensis MR-1
Aligns to 29:235 / 395 (52.4%), covers 64.6% of PF16401, 26.6 bits

• Involvement of a membrane-bound class III adenylate cyclase in regulation of anaerobic respiration in Shewanella oneidensis MR-1
  Charania, Journal of bacteriology 2009
  • “...conditions Locus CRP- and CyaC-downregulated genes SO_3503 SO_3504 SO_3505 SO_3506 SO_3507 SO_3509 SO_3510 SO_3513 Function or description crp mutant/wild type...”

lpl1626 hypothetical protein from Legionella pneumophila str. Lens
Aligns to 10:157 / 372 (39.8%), covers 40.8% of PF16401, 26.1 bits

• Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions
  Gomez-Valero, Frontiers in microbiology 2011
  • “...llb0935 + + + Unknown lpg1660 lpp1631 lpl1625 lpc1090 lpa2398 lpw16861 legL3 LRR lpg1661 lpp1632 lpl1626 lpc1091 lpa2399 lpw16871 llo1691 llb3715 + + + Putative N -acetyl transferase lpg1666 lpp1637 lpl1631 lpc1096 lpa2408 lpw16921 Unknown lpg1667 lpp1638 lpl1632 lpc1097 lpa2409 lpw16931 Unknown lpg1670 lpp1642 lpl1635 lpc1101...”

lpp1632 hypothetical protein from Legionella pneumophila str. Paris
Aligns to 10:167 / 372 (42.5%), covers 50.8% of PF16401, 25.9 bits

• Comparative analyses of Legionella species identifies genetic features of strains causing Legionnaires' disease
  Gomez-Valero, Genome biology 2014
  • “...67 69 lpg1578 / lpp4178 Protein of unknown function 50 37 25 24 lpg1661 / lpp1632 Heparan-alpha glucosaminide N-acetyltransferase d 60 57 47 48 lpg1663 / lpp1634 Protein of unknown function cetLP3 54 44 40 58 lpg1752 / lpp1716 Protein of unknown function mavB 41 40...”
• Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions
  Gomez-Valero, Frontiers in microbiology 2011
  • “...llo0791 llb0935 + + + Unknown lpg1660 lpp1631 lpl1625 lpc1090 lpa2398 lpw16861 legL3 LRR lpg1661 lpp1632 lpl1626 lpc1091 lpa2399 lpw16871 llo1691 llb3715 + + + Putative N -acetyl transferase lpg1666 lpp1637 lpl1631 lpc1096 lpa2408 lpw16921 Unknown lpg1667 lpp1638 lpl1632 lpc1097 lpa2409 lpw16931 Unknown lpg1670 lpp1642 lpl1635...”

lpg1661 Hypothetical protein from Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Aligns to 10:158 / 372 (40.1%), covers 40.8% of PF16401, 25.9 bits

• The Legionella genus core effectors display functional conservation among orthologs by themselves or combined with an accessory protein
  Wexler, Current research in microbial sciences 2022
  • “...Name Size (AA) TMs a Sp. b Domains c Int. d Known function e . lpg1661 372 10 54 AcT lpg0086 LceA 648 8 59 CC + lpg2552 LecE 555 8 27 Activates Pah1 lpg2815 MavN 683 8 59 + Iron acquisition lpg2888 637 8 54...”
• Comparative analyses of Legionella species identifies genetic features of strains causing Legionnaires' disease
  Gomez-Valero, Genome biology 2014
  • “...80 71 67 69 lpg1578 / lpp4178 Protein of unknown function 50 37 25 24 lpg1661 / lpp1632 Heparan-alpha glucosaminide N-acetyltransferase d 60 57 47 48 lpg1663 / lpp1634 Protein of unknown function cetLP3 54 44 40 58 lpg1752 / lpp1716 Protein of unknown function mavB...”
• Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions
  Gomez-Valero, Frontiers in microbiology 2011
  • “...lpa2390 llo0791 llb0935 + + + Unknown lpg1660 lpp1631 lpl1625 lpc1090 lpa2398 lpw16861 legL3 LRR lpg1661 lpp1632 lpl1626 lpc1091 lpa2399 lpw16871 llo1691 llb3715 + + + Putative N -acetyl transferase lpg1666 lpp1637 lpl1631 lpc1096 lpa2408 lpw16921 Unknown lpg1667 lpp1638 lpl1632 lpc1097 lpa2409 lpw16931 Unknown lpg1670 lpp1642...”

H9EWF5 Heparan-alpha-glucosaminide N-acetyltransferase from Macaca mulatta
Aligns to 265:364 / 635 (15.7%), covers 21.9% of PF16401, 25.1 bits

• A genetic and clinical study of individuals with nonsyndromic retinopathy consequent upon sequence variants in HGSNAT, the gene associated with Sanfilippo C mucopolysaccharidosis.
  Schiff, American journal of medical genetics. Part C, Seminars in medical genetics 2020
  • “.... Protein sequences used for alignment are Q68QP42 in the human, KZBY75 in the chimp, H9EWF5 in the Rhesus macaque, F1NBK1in the cat, M3X793 in the mouse, Q3UDW8 in the chicken, F1Q893 in the zebrafish, and A0A0A1XN23 in the Melon fruit fly About 4 of the...”

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