Family Search for PF16887 (DUF5081)

PF16887 hits 4 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

lmo0064 lmo0064 from Listeria monocytogenes EGD-e
Aligns to 3:233 / 233 (99.1%), covers 99.6% of PF16887, 349.7 bits

• Extreme genetic diversity in the type VII secretion system of Listeria monocytogenes suggests a role in bacterial antagonism
  Bowran, Microbiology (Reading, England) 2021
  • “...( Fig 3B , Fig S2 ). The first three of these genes lmo0062, lmo0063, lmo0064 are syntenous with the three genes that are adjacent to essC1 in S. aureus strains ( Fig 1C ), and encode homologues of the substrate proteins EsxC (Lmo0062) and EsxB...”

ESSE_STAA3 / A0A0H2XFI6 Type VII secretion system protein EsaE from Staphylococcus aureus (strain USA300) (see paper)
ESSE_STAA8 / Q2G181 Type VII secretion system protein EsaE from Staphylococcus aureus (strain NCTC 8325 / PS 47) (see paper)
SAOUHSC_00266 hypothetical protein from Staphylococcus aureus subsp. aureus NCTC 8325
SAUSA300_0286 hypothetical protein from Staphylococcus aureus subsp. aureus USA300_FPR3757
Aligns to 4:223 / 224 (98.2%), covers 99.6% of PF16887, 280.0 bits

• function: Component of the type VII secretion system (Ess). Plays a role in Esx protein secretion. Plays an essential role in the processing and secretion of EssD.
  subunit: Interacts with EssD.
  disruption phenotype: Deletion affects Esx protein secretion and the production of cytokines during bloodstream infection and also impacts the ability of staphylococci to establish infectious lesions and to manipulate cellular immune responses of the host.
• function: Component of the type VII secretion system (Ess). Plays a role in Esx protein secretion. Plays an essential role in the processing and secretion of EssD.
  subunit: Interacts with EssD (PubMed:27723728). Interacts with EssG (PubMed:27723728). Interacts with EssC (PubMed:27723728).
• Three small partner proteins facilitate the type VII-dependent secretion of an antibacterial nuclease
  Yang, mBio 2023
  • “...were generated using default settings of Alphafold-Multimer ( 45 ) using UniProt entries Q2G179 (EsaD), Q2G181 (EsaE), Q2G179 (EsaG), Q2G182 (EsxB), Q2G183 (EsxC), and Q2G180 (EsxD). The top-ranked Alphafold models were fit into the cryo-EM maps using the fitmap function of USCF ChimeraX ( 43 )....”
• Three small partner proteins facilitate the type VII-dependent secretion export of an antibacterial nuclease
  Yang, 2023
• Three small partner proteins facilitate the type VII-dependent secretion export of an antibacterial nuclease.
  Yang, bioRxiv : the preprint server for biology 2023
  • “...) were generated using the default settings of Alphafold-Multimer 45 using UniProt entries Q2G179 (EsaD), Q2G181 (EsaE), Q2G179 (EsaG), Q2G182 (EsxB), Q2G183 (EsxC), Q2G180 (EsxD). The top ranked Alphafold models were fit into the cryo-EM maps using the fitmap function of USCF ChimeraX (43). The superose...”
• Comprehensive Genome-wide Perturbations via CRISPR Adaptation Reveal Complex Genetics of Antibiotic Sensitivity
  Jiang, Cell 2020
  • “...( Table S1D ). These genes included SAOUHSC_01257 , SAOUHSC_00628 , SAOUHSC_03037 , SAOUHSC_03016 and SAOUHSC_00266 (see Figures S6O S6S ) and Mean of High-Zs column in Table S1D ). Further examination revealed that these spacers had extensive seed-sequence homology (10-nt or more from the PAM-proximal...”
• EssE Promotes Staphylococcus aureus ESS-Dependent Protein Secretion To Modify Host Immune Responses during Infection
  Anderson, Journal of bacteriology 2017
  • “...S. aureus (MRSA) isolate USA300 LAC (SAUSA300_0286) (22). For plasmid complementation studies, we constructed pessE for plasmid-borne, constitutive...”

SAV0291 hypothetical protein from Staphylococcus aureus subsp. aureus Mu50
Aligns to 5:224 / 225 (97.8%), covers 99.6% of PF16887, 274.2 bits

• Comparative Genomics of Plasmid-Bearing Staphylococcus aureus Strains Isolated From Various Retail Meats
  Karki, Frontiers in microbiology 2020
  • “..., or essD ( Figure 5A ). Retail turkey isolates lacked esxC, esxB and the SAV0291 homolog, and exhibited differences in the repeat regions. FIGURE 5 (A) Organization of gene clusters encoding the Type VII secretion system in S. aureus strains according to RAST annotation. The...”

MW0266 hypothetical protein from Staphylococcus aureus subsp. aureus MW2
Aligns to 5:224 / 225 (97.8%), covers 99.6% of PF16887, 272.7 bits

• Rsp inhibits attachment and biofilm formation by repressing fnbA in Staphylococcus aureus MW2
  Lei, Journal of bacteriology 2011
  • “...of California, Berkeley MW0261 MW0262 MW0264 MW0265 MW0266 MW0267 COL-SA1165 MW1410 MW1405 MW1406 MW1408 MW1427 MW1969 MW2260 MW2263 MW2560 MW2573 MW2600...”

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