Family Search for PF17168 (DUF5127)

Running HMMer for PF17168

PF17168 hits 21 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

GTAA_ASPOR / Q2U4L7 Glutaminase A; EC 3.5.1.2 from Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold) (see paper)
Aligns to 105:337 / 690 (33.8%), covers 100.0% of PF17168, 297.9 bits

• function: Glutaminase catalyzes the hydrolysis of glutamine to glutamic acid and plays a key role in nitrogen metabolism. Catalyzes the hydrolysis not only of L-glutamine but also of D-glutamine.
  catalytic activity: H2O + L-glutamine = L-glutamate + NH4(+) (RHEA:15889)

S7S113 Glutaminase GtaA from Gloeophyllum trabeum (strain ATCC 11539 / FP-39264 / Madison 617)
Aligns to 106:337 / 693 (33.5%), covers 100.0% of PF17168, 297.4 bits

• Lignin Metabolism by Selected Fungi and Microbial Consortia for Plant Stimulation: Implications for Biologically Active Humus Genesis.
  Rehman, Microbiology spectrum 2022
  • “...0.230.07 R7RWJ3 Glycoside hydrolase family 71 protein 0.470.15 A0A0C3C4R3 Glycoside hydrolase family 3 protein 0.80.06 S7S113 Glutaminase GtaA 0.280.14 UPI00046216D2 Glucoamylase G2 0.630.22 UPI0004415A45 Glucoamylase 0.930.65 Q75NB5 Glucanase 4.151.82 Q9Y724 Glucanase 0.980.1 U6NLC6 Glucanase 0.440.19 UPI000441823B Family S53 protease 0.90.08 UPI0004416B61 Endopeptidase 1.670.47 Q5W7K4 Endoglucanase 1.480.21...”

AFUA_3G07030, Afu3g07030 glutaminase GtaA from Aspergillus fumigatus Af293
Aligns to 103:335 / 691 (33.7%), covers 100.0% of PF17168, 294.3 bits

• The Aspergillus fumigatus sitA Phosphatase Homologue Is Important for Adhesion, Cell Wall Integrity, Biofilm Formation, and Virulence
  Bom, Eukaryotic cell 2015
  • “...in the WT Afu1g15730 Afu1g14450 Afu3g07030 Afu3g00590 Afu1g05770 Afu1g10970 Afu6g14470 Afu2g00967 Afu6g03210 Afu8g00630 Afu4g09280 Afu4g11800 Afu6g12070...”
• Deletion of the α-(1,3)-glucan synthase genes induces a restructuring of the conidial cell wall responsible for the avirulence of Aspergillus fumigatus
  Beauvais, PLoS pathogens 2013
  • “...13.4 AFUA_2G03510 Putative pheromone processing carboxypeptidase Sxa2 49.75 AFUA_8G04120 Secreted serine carboxypeptidase S1 SCP1 61.28 AFUA_3G07030 Putative secreted glutaminase GtaA 76.15 AFUA_2G12630 allergenic cerato-platanin Aspf13, serine alkaline protease ASPF13 15.94 AFUA_5G02330 allergenic restrictocin, mitogilin Aspf1 ASPF1 19.59 AFUA_4G03660 Putative acid phosphatase, PhoB regulated 46.1 AFUA_5G09240 Cu,Zn...”
• Evolutionary Analysis of Sequence Divergence and Diversity of Duplicate Genes in Aspergillus fumigatus
  Yang, Evolutionary bioinformatics online 2012
  • “...Afu5g02850 20 4 Afu4g00730, Afu8g01530, Afu2g14320, Afu3g13130 21 3 Afu2g11270, Afu3g00910, Afu1g15440 22 3 Afu3g10910, Afu3g07030, Afu6g09910 23 3 Afu1g17570, Afu1g04870, Afu6g03200 24 3 Afu2g05880, Afu1g10930, Afu5g11020 25 3 Afu8g00770, Afu7g05550, Afu2g09450 26 3 Afu2g09520, Afu6g11600, Afu6g07480 27 3 Afu3g01170, Afu7g01590, Afu5g13810 28 3 Afu7g00420, Afu8g06100,...”
• A sterol-regulatory element binding protein is required for cell polarity, hypoxia adaptation, azole drug resistance, and virulence in Aspergillus fumigatus
  Willger, PLoS pathogens 2008
  • “...12.92 AFUA_8g00190 cytochrome P450, putative 11.40 AFUA_1g16250 alpha-glucosidase B 9.95 AFUA_3g12960 cytochrome P450, putative 8.97 AFUA_3g07030 glutaminase A 8.24 AFUA_8g00620 dimethylallyl tryptophan synthase, putative 7.65 AFUA_4g09980 cytochrome P450 monooxygenase, putative 7.15 OTHER AND UNKNOWN GENES AFUA_6g03680 hypothetical protein 13.55 AFUA_3g07870 conserved hypothetical protein 13.23 AFUA_8g04380 conserved...”

G2QFL3 Glutaminase GtaA from Thermothelomyces thermophilus (strain ATCC 42464 / BCRC 31852 / DSM 1799)
Aligns to 101:333 / 686 (34.0%), covers 100.0% of PF17168, 286.6 bits

• Quantitative comparison of the biomass-degrading enzyme repertoires of five filamentous fungi.
  Arntzen, Scientific reports 2020
  • “...extracellular exoglucanases 40 . Thus, DUF1996 may be associated with polysaccharide degradation. The other protein, G2QFL3, had four unknown domains, DUF4964, DUF5127, DUF4965 and DUF1793 (Pfam: PF16334, PF17168, PF16335 and PF08760, respectively), where two of the domains seem to be part of a GH superfamily according...”

An02g13750 uncharacterized protein from Aspergillus niger
Aligns to 103:335 / 691 (33.7%), covers 100.0% of PF17168, 283.4 bits

• A Transcriptome Meta-Analysis Proposes Novel Biological Roles for the Antifungal Protein AnAFP in Aspergillus niger
  Paege, PloS one 2016
  • “...to gibberellin 7-oxidase Cucurbita maxima 0.55 An12g05380 similarity to cercosporin transporter CFP Cercospora kikuchii 0.65 An02g13750 similarity to glutaminase A GtaA involved in ochratoxin A biosynthesis A . oryzae 0.65 An01g06930 similarity to polyketide synthase FUM5 Gibberella moniliformis 0.6 An01g12050 similarity to 15-decalonectrin 15-O-acetyltransferase TRI3 of...”
• RNA-sequencing reveals the complexities of the transcriptional response to lignocellulosic biofuel substrates in Aspergillus niger
  Pullan, Fungal biology and biotechnology 2014
  • “...of Carbon and Nitrogen Metabolism TID_51997 An01g03740 D-xylose reductase 0.25 27.73 0.25 242.13 <0.01 TID_52460 An02g13750 Ortholog(s) have extracellular region localization 2.60 35.39 6.74 28.40 <0.01 TID_40496 An15g02410 Has domain(s) with predicted nucleotide binding activity 3.71 2.98 4.41 1.72 0.59 TID_40740 An15g05990 Has domain(s) with predicted...”
• Cytosolic streaming in vegetative mycelium and aerial structures of Aspergillus niger
  Bleichrodt, Studies in mycology 2013
  • “...1066 Strong similarity to cytoplasmic ribosomal protein of the small subunit S30 - Saccharomyces cerevisiae An02g13750 1062 Strong similarity to glutaminase A gtaA - Aspergillus oryzae An07g00020 1054 Strong similarity to hypothetical protein Z - Streptomyces hygroscopicus An12g02740 1051 Weak similarity to ATP-dependent proteinase Clp from...”
  • “...Coccidioides immitis An01g12450 1835 Strong similarity to hypothetical glucan beta-1,3 exoglucanase exgS - Aspergillus phoenicis An02g13750 1738 Strong similarity to glutaminase A gtaA - Aspergillus oryzae An07g08640 1673 Strong similarity to mutanase mutA - Penicillium purporogenum An08g00540 1643 Strong similarity to EST SEQ ID NO:4140 from...”
• Uncovering the genome-wide transcriptional responses of the filamentous fungus Aspergillus niger to lignocellulose using RNA sequencing
  Delmas, PLoS genetics 2012
  • “...Enzymes of Carbon and Nitrogen Metabolism 51997 An01g03740 D-xylose reductase XyrA 1.1 448.7 2.4 52460 An02g13750 Similarity to glutaminase A GtaA - Aspergillus oryzae 2.2 213.7 14.7 40496 An15g02410 Similarity to nitrogen metabolic repression regulator hNmrr - Homo sapiens 0.3 132.6 45.3 40740 An15g05990 Similarity to...”

TRIATDRAFT_129231 uncharacterized protein from Trichoderma atroviride
Aligns to 105:337 / 689 (33.8%), covers 100.0% of PF17168, 280.0 bits

• Secretome data from Trichoderma reesei and Aspergillus niger cultivated in submerged and sequential fermentation methods
  Florencio, Data in brief 2016
  • “...protein x 589115927 Predicted protein x 154322591 Predicted protein x 358390109 Hypothetical proteins Hypothetical protein TRIATDRAFT_129231 x 358386311 Hypothetical protein TRIVIDRAFT_45439 x 358390537 Hypothetical protein TRIATDRAFT_302472 x x 572280833 Hypothetical protein M419DRAFT_97005 x 116199677 Conserved hypothetical protein x 589112113 Hypothetical protein TRIREDRAFT_66935 x x 358386247 Hypothetical...”

K9GD10 Glutaminase GtaA from Penicillium digitatum (strain PHI26 / CECT 20796)
Aligns to 1:226 / 579 (39.0%), covers 96.9% of PF17168, 273.1 bits

• Deciphering Molecular Determinants Underlying Penicillium digitatum's Response to Biological and Chemical Antifungal Agents by Tandem Mass Tag (TMT)-Based High-Resolution LC-MS/MS
  Citores, International journal of molecular sciences 2022
  • “...1.63 28 12 62 K9GLK6 GNAT family acetyltransferase, putative 1.33 1.6 1.58 25 4 18 K9GD10 Glutaminase GtaA 1.3 1.54 1.68 12 5 9 K9F8A6 Pyridoxal kinase 1.26 1.53 1.05 9 2 4 K9GVY3 Thiamine thiazole synthase 1.07 1.06 1.88 27 9 35 K9FRK3 1-aminocyclopropane-1-carboxylate deaminase,...”

NCU03861 glutaminase A from Neurospora crassa OR74A
Aligns to 107:340 / 692 (33.8%), covers 100.0% of PF17168, 256.9 bits

• Analyses of expressed sequence tags in Neurospora reveal rapid evolution of genes associated with the early stages of sexual reproduction in fungi
  Nygren, BMC evolutionary biology 2012
  • “...b 0.386 Anchored cell wall protein-10, Cu,Zn-superoxide dismutase 2e-44 NCU03584 b 0.176 Polyketide synthase 0 NCU03861 0.245 Glutaminase A 0 NCU04034 0.261 Hypothetical protein, 4 transmembrane domains - NCU04628 0.442 C2H2-type zinc finger domain protein 6e-44 NCU04645 0.178 Hypothetical protein, DUF124 domain-containing protein 5e-45 NCU04730 0.168...”

WP_074995790 glutaminase family protein from Streptomyces misionensis
Aligns to 167:398 / 752 (30.9%), covers 99.6% of PF17168, 244.8 bits

• Identification of fungal lignocellulose-degrading biocatalysts secreted by Phanerochaete chrysosporium via activity-based protein profiling
  Schmerling, Communications biology 2022
  • “...41.7Umg 1 protein and a K M of 0.67mM. b Substrate specificity of Phchr2|2915237 and WP_074995790 from S. misionensis . The activity with different p- nitrophenol-based substrates was determined by measuring the release of p NP. The activity on complex polysaccharides was determined via the DNSA...”
  • “...displayed the highest activities with p NP-Glc, p NP-Xyl, lichenan, and beech wood xylan, while WP_074995790, a close homolog of Phchr2|3002168 showed activity only with p NP-Gal as a substrate with a specific activity of 0.85Umg 1 protein. c Kinetic characterization of Phchr2|2915237 using p NP-Glc,...”

SS1G_08889 hypothetical protein from Sclerotinia sclerotiorum 1980 UF-70
Aligns to 115:334 / 738 (29.8%), covers 92.1% of PF17168, 225.3 bits

• ε-poly-_L-lysine Affects the Vegetative Growth, Pathogenicity and Expression Regulation of Necrotrophic Pathogen Sclerotinia sclerotiorum and Botrytis cinerea
  Zhou, Journal of fungi (Basel, Switzerland) 2021
  • “...SsAmy3 , SS1G_13472), meiotic activator RIM4 ( SsRIM4 , SS1G_03997), glutaminase A ( SsGtaA , SS1G_08889 and BcGtaA , BC1G_10486) were reduced in S. sclerotiorum or B. cinerea treated by -PL ( Figure 6 a). Specifically, the expression levels of the ribosomal export protein NMD3 (BC1G_03554)...”
  • “...meiosis [ 40 ] SS1G_13472 alpha-amylase A amy3 0.68 down starch metabolism [ 41 ] SS1G_08889 glutaminase A 1.65 down glutamic acid synthesis [ 42 ] BC1G_10486 glutaminase A 1.11 down glutamic acid synthesis [ 42 ] BC1G_03554 ribosomal export protein NMD3 1.02 up mRNA and...”
• Proteomics research and related functional classification of liquid sclerotial exudates of Sclerotinia ginseng
  Wang, PeerJ 2017
  • “...protein SS1G_05898 36 89,774 4 (1) 1 (1) 0.04 Amino Acid Metabolism gi|154693286| hypothetical protein SS1G_08889 525 81,000 37 (23) 11 (9) 0.74 gi|154691589| hypothetical protein SS1G_00730 78 66,638 10 (6) 4 (2) 0.1 Protein binding gi|1095454060| hypothetical protein sscle_07g057880 42 42,363 2 (1) 1 (1)...”
• An Interspecies Comparative Analysis of the Predicted Secretomes of the Necrotrophic Plant Pathogens Sclerotinia sclerotiorum and Botrytis cinerea
  Heard, PloS one 2015
  • “...glycoside hydrolase family 61 protein C023 SS1G_07836 HP similar to acidic protease SS1G_07837 PP C024 SS1G_08889 glutaminase SS1G_08892 PP SS1G_08894 alpha beta-hydrolase C025 SS1G_09129 6-phospho-beta-galactosidase SS1G_09130 CHP C026 SS1G_09248 hydrophobin SS1G_09250 iron-sulfur cluster-binding rieske family domain protein SS1G_09251 HP similar to endoglucanase II C027 SS1G_09363 -...”

An11g07960 uncharacterized protein from Aspergillus niger
Aligns to 112:330 / 722 (30.3%), covers 99.6% of PF17168, 225.0 bits

• The transcriptomic signature of RacA activation and inactivation provides new insights into the morphogenetic network of Aspergillus niger
  Kwon, PloS one 2013
  • “...wall protein An04g03830 cell wall protein An02g11620 plasma membrane protein An02g08030 Pmp3 GABA metabolism glutaminase An11g07960 -aminobutyrate transaminase An17g00910 Uga1 NAD(+)-dependent glutamate dehydrogenase An02g14590 Gdh2 GABA permease An16g01920 transcription factor for GABA genes An02g07950 Transporter mitochondrial phosphate translocator An02g04160 Mir1 mitochondrial ABC transporter during oxidative stress...”
• Reconstruction of signaling networks regulating fungal morphogenesis by transcriptomics
  Meyer, Eukaryotic cell 2009
  • “...coding for proteins involved in glutamate metabolism (An11g07960 coding for glutaminase and An02g14590 coding for a NAD-dependent glutamate dehydrogenase) were...”
  • “...decarboxylase Alcohol dehydrogenase Amino acid metabolism An11g07960 An17g00910 An02g14590 (9.74) 6.03 3.15 0.025 0.004 0.029 Glutaminase -Aminobutyrate...”

Afu6g09910 glutaminase, putative from Aspergillus fumigatus Af293
Aligns to 113:331 / 721 (30.4%), covers 99.6% of PF17168, 215.9 bits

• Evolutionary Analysis of Sequence Divergence and Diversity of Duplicate Genes in Aspergillus fumigatus
  Yang, Evolutionary bioinformatics online 2012
  • “...20 4 Afu4g00730, Afu8g01530, Afu2g14320, Afu3g13130 21 3 Afu2g11270, Afu3g00910, Afu1g15440 22 3 Afu3g10910, Afu3g07030, Afu6g09910 23 3 Afu1g17570, Afu1g04870, Afu6g03200 24 3 Afu2g05880, Afu1g10930, Afu5g11020 25 3 Afu8g00770, Afu7g05550, Afu2g09450 26 3 Afu2g09520, Afu6g11600, Afu6g07480 27 3 Afu3g01170, Afu7g01590, Afu5g13810 28 3 Afu7g00420, Afu8g06100, Afu8g06590...”

BF9343_0291 glutaminase domain-containing protein from Bacteroides fragilis NCTC 9343
Aligns to 258:476 / 826 (26.5%), covers 99.1% of PF17168, 210.4 bits

• Multi-omics approach for understanding the response of Bacteroides fragilis to carbapenems
  Zholdybayeva, Heliyon 2024
  • “...2,71E+00 unknown function BF9343_1393 Bacteriophage-related replication protein (BF9343_1393) 5,05E+00 BF9343_2497 DUF169 domain-containing protein (I6J55_RS01150) 8,11E-01 BF9343_0291 Exported glutaminase (BF9343_0291) 1,02E+00 BF9343_0624 Lipoprotein (BF9343_0624) 2,88E+00 BF9343_3647 Liporotein (BF9343_3647) 5,07E+00 BF9343_3659 Membrane protein (BF9343_3659) 2,92E+00 BF9343_1783 Putative lipoprotein (BF9343_1783) 1,07E+00 BF9343_1767 Putative peptidase (BF9343_1767) 2,64E+00 BF9343_1640 TonB-dependent receptor...”

UMAG_06158 putative glutaminase A from Ustilago maydis 521
Aligns to 243:482 / 912 (26.3%), covers 100.0% of PF17168, 171.4 bits

• N-glycosylation of the protein disulfide isomerase Pdi1 ensures full Ustilago maydis virulence
  Marín-Menguiano, PLoS pathogens 2019
  • “...conditions. We found 6 secreted proteins showing differential electrophoretic mobility in wt versus pdi1 cells: UMAG_06158 (probable glutaminase A), UMAG_01829 (Afg1, previously identified in our first screening, see Fig 2 ), UMAG_04503, an -N-acetylgalactosaminidase, and UMAG_01213, UMAG_00027 and UMAG_11462 (3 uncharacterized proteins) (see Fig 8 )....”

B0XXQ4 Glutaminase, putative from Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)
AFUA_3G10910, Afu3g10910 glutaminase, putative from Aspergillus fumigatus Af293
Aligns to 114:347 / 834 (28.1%), covers 99.6% of PF17168, 164.5 bits

• Assembly and disassembly of Aspergillus fumigatus conidial rodlets
  Valsecchi, Cell surface (Amsterdam, Netherlands) 2019
  • “...B0YDZ9 Ser/Thr protein phosphatase family protein Yes 0.73 23.90 666 75.547 565267 4.7 AFUB_038220 AFUA_3G10910 B0XXQ4 Glutaminase, putative Yes 0.65 17.90 834 92.757 548343 6.0 AFUB_080680 AFUA_8G07120 B0Y9D8 Beta-1,6-glucanase, putative No 0.55 23.60 488 51.430 533200 2.7 AFUB_024700 AFUA_2G08790 B0XRS8 Putative metallocarboxypeptidase ecm14 Yes 0.95 6.70...”
  • “...AFUA_3G03060 B0Y004 Cell wall protein phiA No 0.58 37.80 185 19.380 2437133 3.0 AFUB_038220 AFUA_3G10910 B0XXQ4 Glutaminase, putative Yes 0.65 17.90 834 92.757 2213600 12.3 AFUB_087640 AFUA_7G01060 B0YBS2 Cysteine-rich secreted protein No 0.81 22.40 343 36.860 2169400 3.7 AFUB_072730 AFUA_6G06800 B0Y766 Probable carboxypeptidase Yes 0.58 25.90...”
• At the metal-metabolite interface in Aspergillus fumigatus: towards untangling the intersecting roles of zinc and gliotoxin
  Traynor, Microbiology (Reading, England) 2021
  • “...46.7 AFUA_5G14330 Thioredoxin reductase 3.27287 0.001762 21 74 AFUA_4G12990 Glutaminase, putative 3.06718 0.000768 18 28.9 AFUA_3G10910 NADH-dependent flavin oxidoreductase, putative 2.72911 0.001482 21 53.8 AFUA_7G06420 Catalase B CatB/1 2.66263 0.003534 98 76.8 AFUA_3G02270 Oxidoreductase, short-chain dehydrogenase/reductase family 2.40285 0.003956 5 34.3 AFUA_4G03680 Homocysteine synthase CysD 1.97439...”
• Assembly and disassembly of Aspergillus fumigatus conidial rodlets
  Valsecchi, Cell surface (Amsterdam, Netherlands) 2019
  • “...AFUA_6G00160 B0YDZ9 Ser/Thr protein phosphatase family protein Yes 0.73 23.90 666 75.547 565267 4.7 AFUB_038220 AFUA_3G10910 B0XXQ4 Glutaminase, putative Yes 0.65 17.90 834 92.757 548343 6.0 AFUB_080680 AFUA_8G07120 B0Y9D8 Beta-1,6-glucanase, putative No 0.55 23.60 488 51.430 533200 2.7 AFUB_024700 AFUA_2G08790 B0XRS8 Putative metallocarboxypeptidase ecm14 Yes 0.95...”
  • “...AFUB_045170 AFUA_3G03060 B0Y004 Cell wall protein phiA No 0.58 37.80 185 19.380 2437133 3.0 AFUB_038220 AFUA_3G10910 B0XXQ4 Glutaminase, putative Yes 0.65 17.90 834 92.757 2213600 12.3 AFUB_087640 AFUA_7G01060 B0YBS2 Cysteine-rich secreted protein No 0.81 22.40 343 36.860 2169400 3.7 AFUB_072730 AFUA_6G06800 B0Y766 Probable carboxypeptidase Yes 0.58...”
• Evolutionary Analysis of Sequence Divergence and Diversity of Duplicate Genes in Aspergillus fumigatus
  Yang, Evolutionary bioinformatics online 2012
  • “...Afu1g12190, Afu5g02850 20 4 Afu4g00730, Afu8g01530, Afu2g14320, Afu3g13130 21 3 Afu2g11270, Afu3g00910, Afu1g15440 22 3 Afu3g10910, Afu3g07030, Afu6g09910 23 3 Afu1g17570, Afu1g04870, Afu6g03200 24 3 Afu2g05880, Afu1g10930, Afu5g11020 25 3 Afu8g00770, Afu7g05550, Afu2g09450 26 3 Afu2g09520, Afu6g11600, Afu6g07480 27 3 Afu3g01170, Afu7g01590, Afu5g13810 28 3 Afu7g00420,...”

G4N1P6 Glutaminase GtaA from Pyricularia oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
MGG_07512 glutaminase GtaA from Pyricularia oryzae 70-15
Aligns to 109:349 / 828 (29.1%), covers 97.4% of PF17168, 145.2 bits

• A protein kinase coordinates cycles of autophagy and glutaminolysis in invasive hyphae of the fungus Magnaporthe oryzae within rice cells
  Li, Nature communications 2023
  • “...than for Gdh2 (Supplementary Data 1 ). We detected a putative glutaminase (MGG_07512; UniProt identifier: G4N1P6) that might catalyze the first step of glutaminolysis, but it was 289-fold less abundant (Supplementary Data 1 ) than Glt1 (MGG_07187; UniProt identifier: G4MTM7) encoding glutamate synthase, an enzyme that...”
• A protein kinase coordinates cycles of autophagy and glutaminolysis in invasive hyphae of the fungus Magnaporthe oryzae within rice cells
  Li, Nature communications 2023
  • “...were 472-fold lower than for Gdh2 (Supplementary Data 1 ). We detected a putative glutaminase (MGG_07512; UniProt identifier: G4N1P6) that might catalyze the first step of glutaminolysis, but it was 289-fold less abundant (Supplementary Data 1 ) than Glt1 (MGG_07187; UniProt identifier: G4MTM7) encoding glutamate synthase,...”

GTAA_ARTBC / D4AMT2 Probable glutaminase ARB_05535/05536; EC 3.5.1.2 from Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes) (see paper)
Aligns to 116:350 / 862 (27.3%), covers 96.0% of PF17168, 142.9 bits

• function: Glutaminase catalyzes the hydrolysis of glutamine to glutamic acid and plays a key role in nitrogen metabolism (By similarity).
  catalytic activity: H2O + L-glutamine = L-glutamate + NH4(+) (RHEA:15889)

R1GV87 Putative glutaminase protein from Botryosphaeria parva (strain UCR-NP2)
Aligns to 113:352 / 854 (28.1%), covers 99.1% of PF17168, 140.9 bits

• Unveiling the Secretome of the Fungal Plant Pathogen Neofusicoccum parvum Induced by In Vitro Host Mimicry.
  Nazar, Journal of fungi (Basel, Switzerland) 2022
  • “...R1FZX2, and R1H1L9), proteinprotein interactions (R1ENG6, R1E9S0, and R1GCJ5), and proteins with other functions (R1EGT1, R1GV87, R1EAF3, R1G1U2, R1FV21, R1FVG4, R1GBA7, R1EWZ5, R1GDV3, R1GKT0, R1E681)were also identified ( Figure 1 and Table 2 ). 3.2. ProteinProtein Interaction Due to the lack of data available on the...”
  • “...beta hydrolase protein R1EGT1 2.7 3.692 11 3.31 10 9 118.1 Extracellular Putative glutaminase protein R1GV87 2.7 3.603 10 1.15 10 9 215.65 Extracellular Putative fasciclin domain family protein R1EWZ5 2 2.878 12 2.37 10 9 129.86 Extracellular Uncharacterized protein R1GDV3 4.1 2.108 5 3.67 10...”

C1FYE6 Glutaminase from Paracoccidioides brasiliensis (strain Pb18)
Aligns to 125:360 / 903 (26.1%), covers 96.0% of PF17168, 138.9 bits

• Extracellular vesicles from virulent P. brasiliensis induce TLR4 and dectin-1 expression in innate cells and promote enhanced Th1/Th17 response
  Montanari, Virulence 2024
  • “...3,898842 8,58E05 C1G6P2 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase UP(D) 3,82139 4,39E05 C1G0F9 kynureninase [EC:3.7.1.3] UP(D) 3,62137 9,06E05 C1FYE6 Glutaminase A UP(D) 3,433912 0,000121 Lipid metabolism C1GDH4 leukotriene-A4 hydrolase [EC:3.3.2.6] UP(D) 4,263176 0,000274 C1GMW7 Sphingolipid C9-methyltransferase A UP (8S) 3,572532 0,037729 C1G0P4 long-chain acyl-CoA synthetase [EC:6.2.1.3] UP (12S) 3,064416...”

7w2tA / F6BL85 Crystal structure of txgh116 e730q mutant from thermoanaerobacterium xylanolyticum with glucose
Aligns to 128:366 / 773 (30.9%), covers 93.8% of PF17168, 35.2 bits

• Ligands: beta-d-glucopyranose; calcium ion (7w2tA)

F6BL85 glucosylceramidase (EC 3.2.1.45) from Thermoanaerobacterium xylanolyticum (see paper)
AEF18218.1 β-glucosidase (TxGH116;Thexy_2211) (EC 3.2.1.21) (see protein)
Aligns to 158:396 / 806 (29.7%), covers 93.8% of PF17168, 35.1 bits

Or search for genetic data about PF17168 in the Fitness Browser