Family Search for PF17659 (DUF5521)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

PF17659 hits 3 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

RADX_HUMAN / Q6NSI4 RPA-related protein RADX; RPA-related and RAD51-antagonist, X-chromosome from Homo sapiens (Human) (see paper)
NP_060485 RPA-related protein RADX isoform 1 from Homo sapiens
Aligns to 2:849 / 855 (99.2%), covers 100.0% of PF17659, 1826.2 bits

• function: Single-stranded DNA-binding protein recruited to replication forks to maintain genome stability (PubMed:28735897). Prevents fork collapse by antagonizing the accumulation of RAD51 at forks to ensure the proper balance of fork remodeling and protection without interfering with the capacity of cells to complete homologous recombination of double-strand breaks (PubMed:28735897).
• Genome-wide transcriptional response of primary alveolar macrophages following infection with porcine reproductive and respiratory syndrome virus
  Genini, The Journal of general virology 2008
  • “...MESDC1 Mesoderm development candidate 1 Ssc.26318.1.S1_at 0.638 DNCL1 Dynein light chain 1, cytoplasmic Ssc.24811.1.A1_at 0.638 Q6NSI4 Nuclear receptor-binding protein 2 (NRBP2) ( Bos taurus ) Ssc.1153.1.A1_at 0.638 C9orf28 C9orf28 protein Ssc.22634.1.S1_at 0.637 RB1CC1 Rb1-inducible coiled-coil protein 1 ( Homo sapiens ) Ssc.19778.1.S1_at 0.633 TNF-IP8L2 Tumour necrosis...”
• Oligomerization of DNA replication regulatory protein RADX is essential to maintain replication fork stability.
  Mohamed, The Journal of biological chemistry 2022
  • GeneRIF: Oligomerization of DNA replication regulatory protein RADX is essential to maintain replication fork stability.
• RADX controls RAD51 filament dynamics to regulate replication fork stability.
  Adolph, Molecular cell 2021
  • GeneRIF: RADX controls RAD51 filament dynamics to regulate replication fork stability.
• RADX Modulates RAD51 Activity to Control Replication Fork Protection.
  Bhat, Cell reports 2018
  • GeneRIF: RADX buffers RAD51 to ensure the right amount of reversal and protection to maintain genome stability.
• RADX Promotes Genome Stability and Modulates Chemosensitivity by Regulating RAD51 at Replication Forks.
  Dungrawala, Molecular cell 2017
  • GeneRIF: By antagonizing RAD51 at forks, RADX allows cells to maintain a high capacity for homology-directed repair while ensuring that replication functions of RAD51 are properly regulated. Thus, RADX is essential to achieve the proper balance of RAD51 activity to maintain genome stability.
• RADX interacts with single-stranded DNA to promote replication fork stability.
  Schubert, EMBO reports 2017
  • GeneRIF: RADX interacts with single-stranded DNA to promote replication fork stability.

Q8C779 RPA-related protein RADX from Mus musculus
Aligns to 2:847 / 850 (99.5%), covers 100.0% of PF17659, 1698.2 bits

• Proteomics of autism and Alzheimer's mouse models reveal common alterations in mTOR signaling pathway.
  Mencer, Translational psychiatry 2021
  • “...protein 1 Q6PDI5 Proteasome-associated protein ECM29 homolog Q06335 Amyloid-like protein 2 Q8BGQ7 AlaninetRNA ligase, cytoplasmic Q8C779 Uncharacterized protein CXorf57 homolog Q9QZE7 Translin-associated protein X Q9QZQ1 Afadin Q91Y44 Bromodomain testis-specific protein Q8BUH8 Sentrin-specific protease 7 Q3UQ44 Ras GTPase-activating-like protein IQGAP2 Q8CHY6 Transcriptional repressor p66 alpha Q6PGA0 REST...”

8u5yB / Q6NSI4 8u5yB (see paper)
2 alignments in 1:698 / 700 (99.7%), covering up to 61.8% of PF17659, 1585.9 bits

• Ligand: dna (8u5yB)

Or search for genetic data about PF17659 in the Fitness Browser