Family Search for PF17825 (DUF5587)

Running HMMer for PF17825

PF17825 hits 4 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

SHOC1_HUMAN / Q5VXU9 Protein shortage in chiasmata 1 ortholog; Protein ZIP2 homolog; MZIP2; EC 3.6.-.- from Homo sapiens (Human) (see 4 papers)
Aligns to 1:1444 / 1444 (100.0%), covers 100.0% of PF17825, 2968.6 bits

• function: ATPase required during meiosis for the formation of crossover recombination intermediates (By similarity). Binds DNA: preferentially binds to single-stranded DNA and DNA branched structures (PubMed:29742103). Does not show nuclease activity in vitro, but shows ATPase activity, which is stimulated by the presence of single-stranded DNA (PubMed:29742103). Plays a key role in homologous recombination and crossing-over in meiotic prophase I in male and female germ cells (By similarity). Required for proper synaptonemal complex assembly and homologous chromosome pairing (By similarity). Requiref for recruitment TEX11 and MSH4 to recombination intermediates (By similarity).
  subunit: Interacts with TEX11 (PubMed:29742103). Interacts with SPO16 (By similarity).
• Combining patient proteomics and in vitro cardiomyocyte phenotype testing to identify potential mediators of heart failure with preserved ejection fraction
  Raphael, Journal of translational medicine 2016
  • “...Structural maintenance of chromosomes protein 3 0.0261 GTF2I P78347 General transcription factor II-I 0.0262 CI084 Q5VXU9 Uncharacterized protein 0.0268 CCS O14618 Copper chaperone for superoxide dismutase 0.0294 COX6C P09669 Cytochrome c oxidase subunit 6C 0.0324 INT11 Q5TA45 Integrator complex subunit 11 0.0352 DCLK1 O15075 Serine/threonine-protein kinase...”
• Annotating N termini for the human proteome project: N termini and Nα-acetylation status differentiate stable cleaved protein species from degradation remnants in the human erythrocyte proteome
  Lange, Journal of proteome research 2014
  • “...chromosome chromosome band found in enzyme suggestedreasonwhypreviouslynotidentified Q14773 intercellularadhesionmolecule4 transcript 19 p13.2 preTAILS trypsin celltype/tissue-specificexpression Q5VXU9 uncharacterizedproteinC9orf84 transcript 9 q31.3 TAILS trypsin semispecificpeptiderepresentingC-terminalprocessing Q8N2R8 proteinFAM43A transcript 3 q29 TAILS GluC semispecificNterminalpeptide,useofGluCfordigestion Q6PK30 cancer/testisantigen75 transcript 2 q36.1 TAILS trypsin semispecificNterminalpeptide P57071 PRdomainzincfingerprotein15 transcript 21 q22.3 TAILS |...”
• Expression of endoplasmic reticulum stress proteins is a candidate marker of brain metastasis in both ErbB-2+ and ErbB-2- primary breast tumors.
  Sanz-Pamplona, The American journal of pathology 2011

XP_016869829 protein shortage in chiasmata 1 ortholog isoform X3 from Homo sapiens
Aligns to 85:1395 / 1395 (94.0%), covers 90.5% of PF17825, 2716.0 bits

• Bi-allelic variants in SHOC1 cause non-obstructive azoospermia with meiosis arrest in humans and mice.
  Wang, Molecular human reproduction 2022 (PubMed)
  • GeneRIF: Bi-allelic variants in SHOC1 cause non-obstructive azoospermia with meiosis arrest in humans and mice.
• Bi-allelic SHOC1 loss-of-function mutations cause meiotic arrest and non-obstructive azoospermia.
  Yao, Journal of medical genetics 2021
  • GeneRIF: Bi-allelic SHOC1 loss-of-function mutations cause meiotic arrest and non-obstructive azoospermia.

SHOC1_MOUSE / A2ALV5 Protein shortage in chiasmata 1 ortholog; Protein ZIP2 homolog; MZip2; EC 3.6.-.- from Mus musculus (Mouse) (see 4 papers)
NP_001357772 protein shortage in chiasmata 1 ortholog from Mus musculus
Aligns to 66:1481 / 1481 (95.6%), covers 100.0% of PF17825, 2712.8 bits

• function: ATPase required during meiosis for the formation of crossover recombination intermediates (PubMed:29742103). Binds DNA: preferentially binds to single-stranded DNA and DNA branched structures (By similarity). Does not show nuclease activity in vitro, but shows ATPase activity, which is stimulated by the presence of single-stranded DNA (By similarity). Plays a key role in homologous recombination and crossing-over in meiotic prophase I in male and female germ cells (PubMed:30272023). Required for proper synaptonemal complex assembly and homologous chromosome pairing (PubMed:35485979). Required for recruitment of TEX11 and MSH4 to recombination intermediates (PubMed:30272023).
  subunit: Interacts with TEX11 (By similarity). Interacts with SPO16 (PubMed:30746471).
  disruption phenotype: Mice show severe defects in meiotic prophase I, such as DNA double-strand break (DSB) repair, crossover formation and synapsis in spermatocytes and oocytes resulting in sterility in both male and females (PubMed:30272023). Embryonic lethality due to defects in meiosis (PubMed:29742103). The use of a hypomorphic allele showed that spermatogenesis progresses normally until the end of prophase I when spermatocytes arrest at metaphase I: homologous chromosomes pair in spermatocytes but show defective synapsis (PubMed:29742103).
• Bi-allelic variants in SHOC1 cause non-obstructive azoospermia with meiosis arrest in humans and mice.
  Wang, Molecular human reproduction 2022 (PubMed)
  • GeneRIF: Bi-allelic variants in SHOC1 cause non-obstructive azoospermia with meiosis arrest in humans and mice.
• SHOC1 is a ERCC4-(HhH)2-like protein, integral to the formation of crossover recombination intermediates during mammalian meiosis.
  Guiraldelli, PLoS genetics 2018
  • GeneRIF: Analysis of SHOC1-deficient mice and the selective localization of SHOC1 to a subset of recombination sites show that SHOC1 acts at key mid-stage steps of the genetic crossovers (COs) ormation process.

A6PVK7 Shortage in chiasmata 1 from Homo sapiens
2 alignments in 40:1370 / 1370 (97.2%), covering up to 52.7% of PF17825, 2670.6 bits

• Quantitative proteomic analysis for high-throughput screening of differential glycoproteins in hepatocellular carcinoma serum
  Gao, Cancer biology & medicine 2015
  • “...Wnt OS=Homo sapiens GN=WNT2B PE=2 SV=1 - [Q5TEH8_HUMAN] 2.68 4 1 1 299 33.9 8.90 A6PVK7 Chromosome 9 open reading frame 84 OS=Homo sapiens GN=C9orf84 PE=4 SV=1 - [A6PVK7_HUMAN] 1.02 3 1 1 1,370 157.0 5.50 D6W646 HCG22253, isoform CRA_a OS=Homo sapiens GN=hCG_22253 PE=4 SV=1 -...”
• Altered blood proteome in girls with high urine concentrations of bisphenol a, genistein, mono-ethyl hexylphthalate and mono-benzyl phthalate.
  Wang, MOJ proteomics & bioinformatics 2015
  • “...0.95 5 2.70 1.81 Q96N11 chromosome 7 open reading frame 26 0.83 3 2.41 1.94 A6PVK7 chromosome 9 open reading frame 84 1.00 3 2.26 0.90 Q96PX6 coiled-coil domain-containing 85A 0.92 4 +2.15 1.46 Q8IYT3 coiled-coil domain containing 170 0.98 2 +2.39 0.87 P0C0L5 complement C4B...”

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