Family Search for PF18367 (Rv2175c_C)

PF18367 hits 11 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

P354_28905 Rv2175c family DNA-binding protein from Streptomyces noursei PD-1
Aligns to 65:120 / 121 (46.3%), covers 100.0% of PF18367, 100.1 bits

• Differential protein expression of a streptomycin-resistant Streptomyces albulus mutant in high yield production of ε-poly-l-lysine: a proteomics study
  Liu, RSC advances 2019
  • “...of transcription, DNA-templated MarR family transcriptional regulator DC74_5136 9 9 1.21 0.0124 X0MS01 Transcriptional regulator P354_28905 3 3 1.40 0.0050 X0MWP7 Regulation of transcription, DNA-templated Transcriptional regulator P354_18815 6 6 1.74 0.0001 X0MRL4 Sequence-specific DNA binding DNA-binding protein P354_30280 1 1 1.30 0.0161 X0N564 Integral component...”

SCO2105 transcriptional regulatory protein from Streptomyces coelicolor A3(2)
Aligns to 65:120 / 121 (46.3%), covers 100.0% of PF18367, 98.8 bits

• Extracting regulator activity profiles by integration of de novo motifs and expression data: characterizing key regulators of nutrient depletion responses in Streptomyces coelicolor
  Iqbal, Nucleic acids research 2012
  • “...transcriptional regulatory protein GlnR (SCO4159), ( e ) motif 34: MarR, MerR regulatory proteins (SCO5405, SCO2105) and TetR (SCO3129) family transcriptional regulators and a conserved hypothetical protein(SCO4639) as well as an anti Sigma factor (SCO7324), ( f ) motif 36: Matches to this motif include important...”

Y2175_MYCTU / O53509 DNA-binding protein Rv2175c from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
Rv2175c conserved hypothetical regulatory protein from Mycobacterium tuberculosis H37Rv
NP_216691 DNA-binding protein from Mycobacterium tuberculosis H37Rv
Aligns to 78:145 / 146 (46.6%), covers 100.0% of PF18367, 97.6 bits

• function: Binds DNA at low salt concentrations.
  subunit: Monomer in solution. May form homodimers. Interacts with phosphorylated PknL.
• Elimination of PknL and MSMEG_4242 in Mycobacterium smegmatis alters the character of the outer cell envelope and selects for mutations in Lsr2
  Báez-Ramírez, Cell surface (Amsterdam, Netherlands) 2021
  • “...2021 ). PknL was shown to phosphorylate an adjacent and divergently transcribed, putative transcriptional regulator, Rv2175c ( Canova et al., 2008 , Cohen-Gonsaud et al., 2009 ), reducing its ability to bind DNA, but it is unknown what stimulates this phosphorylation, what genes Rv2175c regulates or...”
  • “...shown to phosphorylate the protein encoded by the adjacent and divergently transcribed, putative transcriptional regulator Rv2175c, the M. tuberculosis equivalent of MSMEG_4242 , which then loses its ability to bind DNA ( Molle and Kremer, 2010 ). In an alternative model, the unphosphorylated MSMEG_4242 /Rv2175c represses...”
• Small RNAs Asserting Big Roles in Mycobacteria
  Coskun, Non-coding RNA 2021
  • “...11 ] 200250 2137148-2137103 (TBD) fbpB-rv1887 TBD Mcr5 [ 11 ] 80 2437823-2437866 () within rv2175c TBD Mcr7 [ 11 , 31 ] 350400 2692172-2692521 (+) rv2395-pe_PGRS41 TBD Mcr8 (candidate_1935) [ 8 , 11 ] 200 4073966-4073908 (TBD) rv3661rv3662c TBD Mcr9 (candidate_1502) [ 8 , 11...”
• Phosphoproteomic Approaches to Discover Novel Substrates of Mycobacterial Ser/Thr Protein Kinases
  Baros, Molecular & cellular proteomics : MCP 2020 (secret)
• Multisystem Analysis of Mycobacterium tuberculosis Reveals Kinase-Dependent Remodeling of the Pathogen-Environment Interface
  Carette, mBio 2018
  • “...by PknA and PknB, respectively ( 22 , 23 ), and one candidate PknL substrate, Rv2175c (only shown to be phosphorylated in vitro ) ( 24 ), have been previously identified. Though these proteins were present in our proteomics data, we did not detect phosphorylation of...”
  • “...spectrometric profiling of the activation loop phosphorylation sites and their role in the recruitment of Rv2175c . Proteomics 8 : 521 533 . doi: 10.1002/pmic.200700442 . 18175374 25. Refaya AK , Sharma D , Kumar V , Bisht D , Narayanan S 2016 A serine/threonine kinase...”
• Hanks-Type Serine/Threonine Protein Kinases and Phosphatases in Bacteria: Roles in Signaling and Adaptation to Various Environments
  Janczarek, International journal of molecular sciences 2018
  • “...spectrometric profiling of the activation loop phosphorylation sites and their role in the recruitment of Rv2175c Proteomics 2008 8 521 533 10.1002/pmic.200700442 18175374 46. Yan J. Zou W. Fang J. Huang X. Gao F. He Z. Zhang K. Zhao N. Eukaryote-like Ser/Thr protein kinase PrkA modulates...”
  • “...44 ] PknL FadD, MabA, KasA, KasB Mycolic acid synthesis [ 21 , 22 ] Rv2175c DNA-binding protein, cell envelope [ 45 ] GroEL1 Heat shock protein [ 29 ] Bacillus subtilis PrkA ND Indirect regulation of transcription factor K and regulator ScoC, sporulation [ 46...”
• Solution NMR Studies of Mycobacterium tuberculosis Proteins for Antibiotic Target Discovery
  Kim, Molecules (Basel, Switzerland) 2017
  • “...domain fold composed of an 11-stranded -sandwich topology ( Figure 1 L). The structure of Rv2175c as a substrate of PknL was also determined [ 47 ]. Rv2175c has two domains: an N-terminal winged helix-turn-helix motif (residues 1877), a DNA-binding domain, and C-terminal effector domain (residues...”
  • “...Figure 1 M). There is some flexibility between the two domains. The solution structure of Rv2175c revealed that the N-terminal part (Met1Ile16) and large loop (Thr110Asn122) were disordered. The chemical shift perturbations of Rv2175c according to the phosphorylation of Thr9 showed no significant structural change in...”
• Molecular Mechanisms of Two-Component Signal Transduction
  Zschiedrich, Journal of molecular biology 2016
  • “...Staphylococcus aureus GraR [ 114 ] and VraR [ 115 ], Mycobacterium tuberculosis DosR and Rv2175c [ 116 118 ] , Streptococcus pneumoniae RitR [ 119 ] and RR06 [ 120 ] and Group A and B Streptococci CovR [ 121 ] have been followed by...”
  • “...spectrometric profiling of the activation loop phosphorylation sites and their role in the recruitment of Rv2175c Proteomics 2008 8 521 533 18175374 118 Cohen-Gonsaud M Barthe P Canova MJ Stagier-Simon C Kremer L Roumestand C Molle V The Mycobacterium tuberculosis Ser/Thr kinase substrate Rv2175c is a...”
• Profiling the Proteome of Mycobacterium tuberculosis during Dormancy and Reactivation
  Gopinath, Molecular & cellular proteomics : MCP 2015
  • “...we found up-regulated at R24, were Rv3058c, EmbR, Rv2175c, Rv1019, Rv2258c, HrcA, DevS, and DevR. EmbR (Rv1267c), a putative transcriptional regulator of...”
  • “...transcriptional regulators DevR, DevS, EmbR, Rv3058c, Rv0474, Rv2175c, PhoU, Rv0818, NusA, HrcA, and Rv2258c were elevated during reactivation. DevR, however,...”
• More
• The Mycobacterium tuberculosis Ser/Thr kinase substrate Rv2175c is a DNA-binding protein regulated by phosphorylation.
  Cohen-Gonsaud, The Journal of biological chemistry 2009
  • GeneRIF: Data show that the DNA-binding activity was completely abrogated in a Rv2175c_T9D mutant.

MT2231 hypothetical protein from Mycobacterium tuberculosis CDC1551
Aligns to 86:153 / 154 (44.2%), covers 100.0% of PF18367, 97.4 bits

• Prediction of prkC-mediated protein serine/threonine phosphorylation sites for bacteria
  Zhang, PloS one 2018
  • “...E . coli tufA (P0CE47). The serine/threonine-protein kinase pknL (P9WI62) could phosphorylate the DNA-binding protein MT2231 in Mycobacterium tuberculosis and was predicted to be involved in transcriptional regulation and cell division [ 27 ]. We predicted that prkC might phosphorylate pknL at T32, T173 and T175...”

MSMEG_4242 transcriptional regulatory protein from Mycobacterium smegmatis str. MC2 155
Aligns to 66:133 / 134 (50.7%), covers 100.0% of PF18367, 96.7 bits

• Elimination of PknL and MSMEG_4242 in Mycobacterium smegmatis alters the character of the outer cell envelope and selects for mutations in Lsr2
  Báez-Ramírez, Cell surface (Amsterdam, Netherlands) 2021
  • “...Surf The Cell Surface 2468-2330 Elsevier 8408660 S2468-2330(21)00013-X 10.1016/j.tcsw.2021.100060 100060 Article Elimination of PknL and MSMEG_4242 in Mycobacterium smegmatis alters the character of the outer cell envelope and selects for mutations in Lsr2 Bez-Ramrez Estalina a Querales Luis a Aranaga Carlos Andres a 1 Lpez Gustavo...”
  • “...access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Highlights Elimination of pknL and adjacent gene MSMEG_4242 in M. smegmatis produces rough & smooth colonies. All smooth colony mutants have inactivated lsr2 genes. Inactivated lsr2 leads to high expression of MSMEG_4727 and increased synthesis of LOS. Smooth...”

MAP1913c hypothetical protein from Mycobacterium avium subsp. paratuberculosis str. k10
Aligns to 86:153 / 154 (44.2%), covers 100.0% of PF18367, 96.3 bits

• Host-Mycobacterium avium subsp. paratuberculosis interactome reveals a novel iron assimilation mechanism linked to nitric oxide stress during early infection
  Lamont, BMC genomics 2013
  • “...networks (Additional file 17 ). Network 1 is composed of 3 upregulated genes, MAP3980 , MAP1913c , and MAP2495 , in MAC-T cells and macrophages (Additional file 17 ). Predicted functions involve sensory transduction regulation ( MAP3980 ) and endonuclease activity for homing activity ( MAP2495...”

ML0898 putative DNA-binding protein from Mycobacterium leprae TN
Aligns to 66:133 / 134 (50.7%), covers 100.0% of PF18367, 93.4 bits

• Developmental biology of Streptomyces from the perspective of 100 actinobacterial genome sequences
  Chandra, FEMS microbiology reviews 2014
  • “...), 1653 ( ML1312 ), 1665 ( ML1299 ), 1929 ( ML0589 ), 2105 ( ML0898 ), 2153 ( ML2446 ), 2154 ( ML0876 ), 2197 ( Lxx10090 ), 2391 ( ML1781 ), 2460 ( Tfu_1340 ), 2557 ( Lxx08190 ), 2643 ( ML1485 ), 2893...”

NCgl2094 Rv2175c family DNA-binding protein from Corynebacterium glutamicum ATCC 13032
Aligns to 68:122 / 123 (44.7%), covers 94.6% of PF18367, 89.4 bits

• Lipoarabinomannan biosynthesis in Corynebacterineae: the interplay of two α(1→2)-mannopyranosyltransferases MptC and MptD in mannan branching
  Mishra, Molecular microbiology 2011
  • “...retained at this locus: a serine/threonine protein kinase ( pknL ), hypothetical proteins (NCgl2099, Rv2179c; NCgl2094, Rv2175c) and a 3-deoxy-7-phosphoheptulonate synthase ( aroG ) ( Fig. 1A ). Fig. 1 Comparative gene relatedness of (12) and (16) mannopyranosyltransferases. A. The genomic region in selected Corynebacterianeae containing...”

D9QBF3 DNA-binding protein from Corynebacterium pseudotuberculosis (strain C231)
Aligns to 62:116 / 117 (47.0%), covers 96.4% of PF18367, 86.7 bits

• Changes in protein abundance are observed in bacterial isolates from a natural host
  Rees, Frontiers in cellular and infection microbiology 2015
  • “...and metabolism D9QBD3 ftsQ CpC231_1388 Cell division protein FtsQ 1.030 * 0.029 Cell wall/membrane/envelope biogenesis D9QBF3 CpC231_1408 CpC231_1408 Transcription regulator 0.978 * 1.194 * 1.055 D9QBI3 lipB CpC231_1439 Octanoyltransferase 1.413 * 2.008 * 0.564 Coenzyme transport and metabolism D9QBL7 CpC231_1476 CpC231_1476 Uncharacterized protein 0.777 * 1.050...”

CpC231_1408 Rv2175c family DNA-binding protein from Corynebacterium pseudotuberculosis C231
Aligns to 67:121 / 122 (45.1%), covers 96.4% of PF18367, 86.6 bits

• Changes in protein abundance are observed in bacterial isolates from a natural host
  Rees, Frontiers in cellular and infection microbiology 2015
  • “...metabolism D9QBD3 ftsQ CpC231_1388 Cell division protein FtsQ 1.030 * 0.029 Cell wall/membrane/envelope biogenesis D9QBF3 CpC231_1408 CpC231_1408 Transcription regulator 0.978 * 1.194 * 1.055 D9QBI3 lipB CpC231_1439 Octanoyltransferase 1.413 * 2.008 * 0.564 Coenzyme transport and metabolism D9QBL7 CpC231_1476 CpC231_1476 Uncharacterized protein 0.777 * 1.050 D9QBM2...”

ACSP50_1631 Rv2175c family DNA-binding protein from Actinoplanes sp. SE50/110
Aligns to 60:115 / 116 (48.3%), covers 98.2% of PF18367, 68.1 bits

• The expression of the acarbose biosynthesis gene cluster in Actinoplanes sp. SE50/110 is dependent on the growth phase
  Droste, BMC genomics 2020
  • “...acb genes to the primary metabolism of Actinoplanes sp. SE50/110. Furthermore, 9 transcriptional regulators ( ACSP50_1631 , ACSP50_2235, ACSP50_4697 , ACSP50_5005 , ACSP50_6401 , ACSP50_6463, ACSP50_8007, ACSP50_8120 and ACSP50_8287 ), a two-component regulator system ( ACSP50_3744 , ACSP50_3745 ) and 2 sigma factor genes ( ACSP50_0644...”

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