Family Search for PF19468 (DUF6005)

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PF19468 hits 4 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

BC1982 hypothetical protein from Bacillus cereus ATCC 14579
Aligns to 7:330 / 331 (97.9%), covers 97.9% of PF19468, 474.9 bits

• Comparative Genomics of Iron-Transporting Systems in Bacillus cereus Strains and Impact of Iron Sources on Growth and Biofilm Formation
  Hayrapetyan, Frontiers in microbiology 2016
  • “...BC1979 asbB Petrobactin biosynthesis protein AsbB BC1980 asbC Acyl-CoA synthetase BC1981 asbD Acyl carrier protein BC1982 asbE Petrobactin biosynthesis protein AsbE BC1983 asbF Hypothetical protein BC4528 fpuA Iron compound ABC transporter substrate-binding protein BC4529 fhuB Iron-hydroxamate transporter permease subunit BC5103 BCE5223 fhuC Iron-siderophore ABC transporter ATP-binding...”

asbE / Q81RQ5 petrobactin synthase from Bacillus anthracis (see 3 papers)
ASBE_BACAN / Q81RQ5 Petrobactin synthase; Petrobactin biosynthesis protein AsbE; EC 2.3.2.- from Bacillus anthracis (see 3 papers)
asbE petrobactin biosynthesis protein AsbE from Bacillus anthracis (see paper)
BA1985 hypothetical protein from Bacillus anthracis str. Ames
Aligns to 3:325 / 327 (98.8%), covers 97.9% of PF19468, 471.0 bits

• function: Involved in the biosynthesis of petrobactin, a catecholate siderophore that functions in both iron acquisition and virulence (PubMed:17189355, PubMed:17346033, PubMed:22408253). Transfers the activated 3,4-dihydroxybenzoate (3,4-DHBA) moiety from 3,4-DHBA-loaded AsbD to different receipient molecules, including N-citryl-spermidine, N8,N'8-citryl-bis(spermidine) and N1-(3,4-dihydroxybenzoyl)-N8,N'8- citryl-bis(spermidine) (PubMed:22408253). Also catalyzes the transfer of the activated 3,4-DHBA moiety from 3,4-DHBA-loaded AsbD to spermidine to generate DHB-spermidine (DHB-SP) (PubMed:17346033).
  catalytic activity: 3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(8)-citryl- spermidine = H(+) + holo-[aryl-carrier protein] + N(1)-(3,4- dihydroxybenzoyl)-N(8)-citryl-spermidine (RHEA:64028)
  catalytic activity: 3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(8),N'(8)- citryl-bis(spermidine) = H(+) + holo-[aryl-carrier protein] + N(1)- (3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine) (RHEA:64024)
  catalytic activity: 3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(1)-(3,4- dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine) = H(+) + holo- [aryl-carrier protein] + petrobactin (RHEA:63820)
  disruption phenotype: The deletion mutant cannot produce petrobactin on iron-depleted medium. In vitro analysis show that mutants grow to a very limited extent as vegetative cells in iron-depleted medium but are not able to outgrow from spores under the same culture conditions.
• Investigating the genome diversity of B. cereus and evolutionary aspects of B. anthracis emergence
  Papazisi, Genomics 2011
  • “...putative + + BA1983 o AMP-binding protein + + BA1984 o hypothetical protein + + BA1985 o hypothetical protein + + BA1986 o conserved hypothetical protein + + BA1992 phospholipase, putative + BA2222 alcohol dehydrogenase, iron-containing + + BA2372 o nonribosomal peptide synthetase DhbF + +...”

BAS1842 hypothetical protein from Bacillus anthracis str. Sterne
Aligns to 7:329 / 331 (97.6%), covers 97.9% of PF19468, 470.9 bits

• Plantazolicin is an ultra-narrow spectrum antibiotic that targets the Bacillus anthracis membrane
  Molohon, ACS infectious diseases 2016
  • “...gene for what is presumably a trimeric ABC transporter) but had an additional mutation in bas1842 , which is implicated in petrobactin biosynthesis. ( 60 ) Upon further inspection, we found that deletion of the petrobactin biosynthetic gene cluster did not decrease susceptibility to PZN, therefore...”
  • “...C248T CitB RR b /luxR family T83M 64 bas1663 : C1127T ABC transporter permease A376V bas1842 : A43G petrobactin biosynthesis, AsbE S15G a MICs were determined by microbroth dilution assay, measured in g/mL b Response regulator Table 3 Effect of B. anthracis Sterne mutations and growth...”

CP157_00999 DUF6005 family protein from Paracoccus marcusii
Aligns to 96:410 / 410 (76.8%), covers 96.3% of PF19468, 374.9 bits

• High Potential for Secondary Metabolite Production of Paracoccus marcusii CP157, Isolated From the Crustacean Cancer pagurus
  Leinberger, Frontiers in microbiology 2021
  • “...similar but not identical to petrobactin. For instance, upstream of asbAB , an acyl-carrier protein (CP157_00999) is encoded that may take over the role of the aryl-carrier protein encoded in asbD in the petrobactin biosynthesis pathway ( Nusca et al., 2012 ). Biosynthetic gene clusters potentially...”

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