Family Search for PF19741 (DUF6230)

PF19741 hits 9 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

C9Z6Y6 Cholesterol esterase from Streptomyces scabiei (strain 87.22)
Aligns to 52:219 / 219 (76.7%), covers 100.0% of PF19741, 204.0 bits

• Physical, Chemical and Proteomic Evidence of Potato Suberin Degradation by the Plant Pathogenic Bacterium Streptomyces scabiei
  Beaulieu, Microbes and environments 2016
  • “...( 17 ). The abundance of most lipases and esterases detected in this study (Sub1, C9Z6Y6, C9YUN4, C9Z1F6, and C9YTK3) increased over time. The maximal production of these lipolytic enzymes in the late phase of the culture may reflect the bacterial growth phase. In some streptomycetes,...”
  • “...Carbohydrate metabolism class (% within the class) Day 10 Day 20 Day 30 Day 60 C9Z6Y6 Cholesterol esterase 0.54 (39.42) 0.68 (34.17) 1.20 (34.19) 1.25 (33.42) C9Z1F6 Lipase 0.22 (16.06) 0.36 (18.09) 0.56 (15.95) 0.62 (16.58) C9YTK3 Lipase 0.11 (8.03) 0.28 (14.01) 0.44 (12.54) 0.36 (9.63)...”
• Comparative secretome analysis of Streptomyces scabiei during growth in the presence or absence of potato suberin
  Komeil, Proteome science 2014
  • “...esterases not specifically produced in the presence of suberin, for instance C9ZG71 (esterase A) and C9Z6Y6 (cholesterol esterase), might nevertheless play a role in suberin degradation (Additional file 1 : Table S1). In a previous study, esterase A was detected in S. scabiei suberin-containing culture medium...”

SLIV_11405 DUF6230 family protein from Streptomyces lividans TK24
Aligns to 44:215 / 215 (80.0%), covers 100.0% of PF19741, 198.1 bits

• Extensive Reannotation of the Genome of the Model Streptomycete Streptomyces lividans TK24 Based on Transcriptome and Proteome Information
  Droste, Frontiers in microbiology 2021
  • “...function Sequence position Actino-pnp RNA RF01688 (Actino-pnp)- pnp RNA degradation 2,286,204 Che1 RNA RF02935 (che1)- SLIV_11405 Cholesterol metabolism 2,630,791 Cobalamin riboswitch RF00174 (Cobalamin)- cbiM - SLIV_08815-SLIV_08820-SLIV_08825 Cobalt transport 2,013,427* Cobalamin riboswitch RF00174 (Cobalamin)- cobD - cobQ-cobN-SLIV_28465 Cobalamin biosynthesis 6,366,946 FMN riboswitch RF00050 (RFN element)- Riboflavin biosynthesis...”

SCO5420 cholesterol esterase from Streptomyces coelicolor A3(2)
Aligns to 44:215 / 215 (80.0%), covers 100.0% of PF19741, 195.7 bits

• Functional connexion of bacterioferritin in antibiotic production and morphological differentiation in Streptomyces coelicolor
  García-Martín, Microbial cell factories 2024 (no snippet)
• Differential transcription of expanded gene families in central carbon metabolism of Streptomyces coelicolor A3(2)
  Schniete, Access microbiology 2020
  • “...utilization genes were expressed more when S. coelicolor was grown on tween, especially cholesterol esterase (SCO5420), which had an increase of almost 37-fold. The enzyme catalyses the hydrolysis of the head group of tween from the fatty acid palmitate, which are then utilized as carbon source...”

Q2AAT6 sterol esterase (EC 3.1.1.13) from Streptomyces sp. (see paper)
Aligns to 44:217 / 217 (80.2%), covers 100.0% of PF19741, 195.6 bits

Q82JC7 sterol esterase (EC 3.1.1.13) from Streptomyces avermitilis (see paper)
Aligns to 44:214 / 214 (79.9%), covers 100.0% of PF19741, 187.4 bits

C9YUN4 Putative exported esterase from Streptomyces scabiei (strain 87.22)
Aligns to 62:219 / 220 (71.8%), covers 97.3% of PF19741, 143.7 bits

• Physical, Chemical and Proteomic Evidence of Potato Suberin Degradation by the Plant Pathogenic Bacterium Streptomyces scabiei
  Beaulieu, Microbes and environments 2016
  • “...17 ). The abundance of most lipases and esterases detected in this study (Sub1, C9Z6Y6, C9YUN4, C9Z1F6, and C9YTK3) increased over time. The maximal production of these lipolytic enzymes in the late phase of the culture may reflect the bacterial growth phase. In some streptomycetes, esterases...”
  • “...(18.09) 0.56 (15.95) 0.62 (16.58) C9YTK3 Lipase 0.11 (8.03) 0.28 (14.01) 0.44 (12.54) 0.36 (9.63) C9YUN4 Cholesterol esterase 0.03 (2.19) 0.10 (5.03) 0.14 (3.99) 0.15 (4.10) C9ZCR8 Suberinase (Sub1) 0.00 (0.00) 0.14 (7.34) 0.26 (7.41) 0.37 (9.89) C9Z5Z2 Glycerophosphoryl diester phosphodiesterase 0.10 (7.30) 0.14 (7.04) 0.18...”

jk2054 putative cholesterol esterase from Corynebacterium jeikeium K411
Aligns to 39:191 / 191 (80.1%), covers 99.3% of PF19741, 87.2 bits

• Analysis of Corynebacterium silvaticum genomes from Portugal reveals a single cluster and a clade suggested to produce diphtheria toxin
  Viana, PeerJ 2023
  • “...jk1103 Cj Tauch etal. (2005) , Tauch & Burkovski (2015) Niche che Cholesterol esterase No jk2054 Cj Tauch etal. (2005) , Tauch & Burkovski (2015) Niche choE Cholesterol oxidase No jk0629 Cj Tauch etal. (2005) , Tauch & Burkovski (2015) Niche cwlH Cell wall-associated hydrolase Yes...”
• Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora
  Tauch, Journal of bacteriology 2005
  • “...jk1699 jk1700 jk1701 jk1702 jk1856 jk0461 jk0448 jk1103 jk0629 jk2054 jk0010 surA surB sapE sapC srtA sapB sapA sapD cbpA nanA asa choE che acpA 58.3 59.3...”
  • “...K411 also encodes a secreted cholesterol esterase (jk2054 [che]) that apparently catalyzes the hydrolysis of long-chain fatty acid esters from cholesterol...”

YP_148893 hypothetical protein from Geobacillus kaustophilus HTA426
GK3040 DUF6230 family protein from Geobacillus kaustophilus HTA426
Aligns to 49:195 / 196 (75.0%), covers 92.5% of PF19741, 54.3 bits

• Alkane inducible proteins in Geobacillus thermoleovorans B23
  Kato, BMC microbiology 2009
  • “...genome sequence, there are genes encoding orthologous proteins to P21 (YP_148623, 99% identical) and P16 (YP_148893, 94% identical). On the other hand, to our most surprise there is no corresponding gene in the genome of G. thermodenitrificans . Gene expression levels of P21 and P16 Because...”
• A novel alkane monooxygenase evolved from a broken piece of ribonucleotide reductase in Geobacillus kaustophilus HTA426 isolated from Mariana Trench
  Nithimethachoke, Extremophiles : life under extreme conditions 2024
  • “...hydratase; (GK3008), 3-hydroxyacyl-CoA dehydrogenase; and GK2777 (GK3007), thiolase/acetyl-CoA acetyltransferase. Surprisingly, the hypothetical proteins GK2770 and GK3040 were orthologous to P21 (99.5% identity, 200/201 aa) and P16 (94.4% identity, 185/196 aa), which are alkane-inducible membrane transporters in G. thermoleovorans B23 (Kato et al. 2009 ). Recently, P21...”

GK2770 DUF6230 family protein from Geobacillus kaustophilus HTA426
YP_148623 hypothetical protein from Geobacillus kaustophilus HTA426
Aligns to 43:194 / 201 (75.6%), covers 93.2% of PF19741, 40.5 bits

• A novel alkane monooxygenase evolved from a broken piece of ribonucleotide reductase in Geobacillus kaustophilus HTA426 isolated from Mariana Trench
  Nithimethachoke, Extremophiles : life under extreme conditions 2024
  • “...reductase; enoyl-CoA hydratase; (GK3008), 3-hydroxyacyl-CoA dehydrogenase; and GK2777 (GK3007), thiolase/acetyl-CoA acetyltransferase. Surprisingly, the hypothetical proteins GK2770 and GK3040 were orthologous to P21 (99.5% identity, 200/201 aa) and P16 (94.4% identity, 185/196 aa), which are alkane-inducible membrane transporters in G. thermoleovorans B23 (Kato et al. 2009 )....”
• Alkane inducible proteins in Geobacillus thermoleovorans B23
  Kato, BMC microbiology 2009
  • “...When we look into its genome sequence, there are genes encoding orthologous proteins to P21 (YP_148623, 99% identical) and P16 (YP_148893, 94% identical). On the other hand, to our most surprise there is no corresponding gene in the genome of G. thermodenitrificans . Gene expression levels...”

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