Family Search for PF20173 (ZnF_RZ-type)
PF20173 hits 19 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.
AFUA_2G05180 NF-X1 finger and helicase domain protein, putative from Aspergillus fumigatus Af293
Aligns to 1848:1901 / 1914 (2.8%), covers 100.0% of PF20173, 81.0 bits
ZNFX1_MOUSE / Q8R151 NFX1-type zinc finger-containing protein 1 from Mus musculus (Mouse) (see paper)
NP_001411605 NFX1-type zinc finger-containing protein 1 isoform a from Mus musculus
Aligns to 1826:1880 / 1909 (2.9%), covers 85.2% of PF20173, 79.2 bits
- function: RNA-binding protein that initiates the antiviral response and is required to restrict the replication of RNA viruses (PubMed:31685995). Acts as a double-stranded RNA (dsRNA) sensor that recognizes viral RNA and then interacts with MAVS to initiate the type I interferon response (PubMed:31685995). Also required for immunity against some bacteria, such as mycobacteria (By similarity).
subunit: Interacts with MAVS.
disruption phenotype: Mice are viable without obvious physiological or behavioral abnormalities (PubMed:31685995). They however display impaired innate immune responses against RNA virus infection by producing less type I interferons (IFNs) (PubMed:31685995). - Molecular characterization of accripin11, a soluble shell protein with an acidic C-terminus, identified in the prismatic layer of the Mediterranean fan mussel Pinna nobilis (Bivalvia, Pteriomorphia)
Khurshid, FEBS open bio 2023 - “...the cysteine pattern (shaded blocks) with that of one zinc finger protein (SwissProt accession number Q8R151) and one keratinassociated protein (SwissProt accession number Q64507) of Mus musculus . Fig.S3. 3D structure prediction with AlphaFold2 of the 6 putative molluscan shell sequences that were found to be...”
- Norbergenin prevents LPS-induced inflammatory responses in macrophages through inhibiting NFκB, MAPK and STAT3 activation and blocking metabolic reprogramming.
Li, Frontiers in immunology 2023 - “...metabolic pathway. Category Gene name UniProt ID Protein name Log2 FC Regulation Inflammatory response Znfx1 Q8R151 NFX1-type zinc finger-containing protein 1 -0.988 Down Epsti1 Q8VDI1 Epithelial-stromal interaction protein 1 -1.246 Down Lcp2 Q60787 Lymphocyte cytosolic protein 2 -1.192 Down Tnfaip2 Q61333 Tumor necrosis factor alpha-induced protein...”
- Genomic variants in an inbred mouse model predict mania-like behaviors
Saul, PloS one 2018 - “...Npas2 P97460 Missense L481P 0.23 chr2:25363944 C/T Uap1l1 Q3TW96 Missense G300D 0.13 chr2:167036853 C/T Znfx1 Q8R151 Missense G1868S 0.00 chr3:19980665 T/G Cp G3X8Q5 Missense C712G 0.01 chr3:19987423 G/A Cp G3X9T8 Missense S903N 0.22 chr3:20005467 T/C Cp G3UXD2 Missense, Splice V23A --- chr3:20012808 C/A Hps3 E9PZY1 Missense...”
- ZNFX1 promotes AMPK-mediated autophagy against Mycobacterium tuberculosis by stabilizing Prkaa2 mRNA.
Liu, JCI insight 2024 - GeneRIF: ZNFX1 promotes AMPK-mediated autophagy against Mycobacterium tuberculosis by stabilizing Prkaa2 mRNA.
- ZNFX1 antisense RNA1 promotes antiviral innate immune responses via modulating ZNFX1 function.
Jia, Journal of medical virology 2023 (PubMed)- GeneRIF: ZNFX1 antisense RNA1 promotes antiviral innate immune responses via modulating ZNFX1 function.
- Mitochondria-localised ZNFX1 functions as a dsRNA sensor to initiate antiviral responses through MAVS.
Wang, Nature cell biology 2019 (PubMed)- GeneRIF: Mitochondria-localized ZNFX1 functions as a dsRNA sensor to initiate antiviral responses through MAVS.
R213A_DANRE / A0A0R4IBK5 E3 ubiquitin-protein ligase rnf213-alpha; E3 ubiquitin-lipopolysaccharide ligase rnf213-alpha; Mysterin-A; Mysterin-alpha; RING finger protein 213-A; RING finger protein 213-alpha; EC 2.3.2.27; EC 3.6.4.-; EC 2.3.2.- from Danio rerio (Zebrafish) (Brachydanio rerio) (see 4 papers)
Aligns to 4494:4547 / 5209 (1.0%), covers 96.3% of PF20173, 79.1 bits
- function: Atypical E3 ubiquitin ligase that can catalyze ubiquitination of both proteins and lipids, and which is involved in various processes, such as lipid metabolism, angiogenesis and cell-autonomous immunity (By similarity). Acts as a key immune sensor by catalyzing ubiquitination of the lipid A moiety of bacterial lipopolysaccharide (LPS) via its RZ-type zinc-finger: restricts the proliferation of cytosolic bacteria, such as Salmonella, by generating the bacterial ubiquitin coat through the ubiquitination of LPS (By similarity). Ubiquitination of LPS triggers cell-autonomous immunity, such as antibacterial autophagy, leading to degradation of the microbial invader (By similarity). Involved in lipid metabolism by regulating fat storage and lipid droplet formation; act by inhibiting the lipolytic process (PubMed:30705059). Also regulates lipotoxicity by inhibiting desaturation of fatty acids (By similarity). Also acts as an E3 ubiquitin-protein ligase via its RING-type zinc finger (By similarity). Involved in the non-canonical Wnt signaling pathway in vascular development: acts by mediating ubiquitination and degradation of proteins downstream of rspo3, leading to inhibit the non-canonical Wnt signaling pathway and promoting vessel regression (By similarity). Also has ATPase activity; ATPase activity is required for ubiquitination of LPS (By similarity). Also involved in neuromuscular regulation (PubMed:26530008).
catalytic activity: S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
catalytic activity: ATP + H2O = ADP + H(+) + phosphate (RHEA:13065)
disruption phenotype: Morpholino knockdown leads to a slight reduction in body size, a small eye and a wavy trunk (PubMed:21799892). Fishes develope abnormal angiogenesis in intersegmental vessels and cranial secondary vessels (PubMed:21799892, PubMed:27125596). Abnormal sprouting vessels are observed in the trunk and head regions, while axial trunk vessels, the dorsal aorta and posterior cardinal vein proceed almost normally (PubMed:21799892). Morpholino knockdown in larvae leads to a reduction in fast myofibrils and immature projection of primary motoneurons, leading to severe motor deficits (PubMed:26530008). Decreased lipid droplet formation (PubMed:30705059).
NP_001376200 NFX1-type zinc finger-containing protein 1 from Rattus norvegicus
Aligns to 1824:1879 / 1907 (2.9%), covers 85.2% of PF20173, 79.1 bits
LOC101857249 NFX1-type zinc finger-containing protein 1 from Aplysia californica
Aligns to 1797:1851 / 1887 (2.9%), covers 87.0% of PF20173, 77.7 bits
- In search of the Aplysia immunome: an in silico study
Kron, BMC genomics 2022 - “...conserved domains, PANTHER annotation from IPS (PTHR10887:SF470), and homology search, three potential ZNFX1 genes (LOC101862822, LOC101857249, LOC101851452) were identified. Several DNA-damage detecting proteins have also been implicated in cytosolic sensing of viral nucleotide [ 32 , 33 ]. Putative orthologs of several of these, including all...”
- “...IPR013785 4 LOC101856483, LOC101856246, LOC101847430, LOC101847031 ZNFX1 IPR041677, IPR041679, IPR000967, IPR016024 IPR045055, IPR041677, IPR041679 3 LOC101857249, LOC101862822, LOC101851452 RNAi RNA interference (RNAi) is another potent antiviral mechanism of particular importance in arthropods [ 88 ]. Key components of the RISC RNAi complex, including Dicer (LOC101848232), two...”
U3IUP4 Zinc finger NFX1-type containing 1 from Anas platyrhynchos platyrhynchos
Aligns to 2026:2081 / 2110 (2.7%), covers 85.2% of PF20173, 77.0 bits
ZNFX1_HUMAN / Q9P2E3 NFX1-type zinc finger-containing protein 1 from Homo sapiens (Human) (see 3 papers)
Aligns to 1834:1889 / 1918 (2.9%), covers 85.2% of PF20173, 76.2 bits
U6CWZ8 NFX1-type zinc finger-containing protein 1 from Neovison vison
Aligns to 1837:1892 / 1921 (2.9%), covers 87.0% of PF20173, 75.9 bits
I3L5Z9 Zinc finger NFX1-type containing 1 from Sus scrofa
Aligns to 1842:1897 / 1926 (2.9%), covers 87.0% of PF20173, 75.6 bits
- Proteomic Characterization of PAMs with PRRSV-ADE Infection.
Xu, Viruses 2022 - “...0.018624 F1SCY2 Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3)/Interferon-stimulated gene 60 (ISG60) IFIT3/ISG60 0.426091944 0.000606 I3L5Z9 Zinc finger NFX1-type containing 1 (ZNFX1) ZNFX1 0.408049746 0.000009 I3LB04 Interferon-stimulated gene 20 (ISG20) ISG20 0.519256582 0.004996 J7FIC7 Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1)/Interferon-stimulated gene 56 (ISG56) IFIT1/ISG56 0.462410477...”
A0A662Z298 E3 ubiquitin-protein ligase RNF213 from Acipenser ruthenus
Aligns to 4423:4478 / 5134 (1.1%), covers 96.3% of PF20173, 70.2 bits
NP_001243000 E3 ubiquitin-protein ligase RNF213 isoform 3 from Homo sapiens
Aligns to 4490:4545 / 5207 (1.1%), covers 85.2% of PF20173, 70.1 bits
RN213_HUMAN / Q63HN8 E3 ubiquitin-protein ligase RNF213; ALK lymphoma oligomerization partner on chromosome 17; E3 ubiquitin-lipopolysaccharide ligase RNF213; Mysterin; RING finger protein 213; EC 2.3.2.27; EC 3.6.4.-; EC 2.3.2.- from Homo sapiens (Human) (see 28 papers)
Aligns to 4490:4545 / 5207 (1.1%), covers 85.2% of PF20173, 70.1 bits
- function: Atypical E3 ubiquitin ligase that can catalyze ubiquitination of both proteins and lipids, and which is involved in various processes, such as lipid metabolism, angiogenesis and cell-autonomous immunity (PubMed:21799892, PubMed:26126547, PubMed:26278786, PubMed:26766444, PubMed:30705059, PubMed:32139119, PubMed:34012115). Acts as a key immune sensor by catalyzing ubiquitination of the lipid A moiety of bacterial lipopolysaccharide (LPS) via its RZ-type zinc- finger: restricts the proliferation of cytosolic bacteria, such as Salmonella, by generating the bacterial ubiquitin coat through the ubiquitination of LPS (PubMed:34012115). Also acts indirectly by mediating the recruitment of the LUBAC complex, which conjugates linear polyubiquitin chains (PubMed:34012115). Ubiquitination of LPS triggers cell-autonomous immunity, such as antibacterial autophagy, leading to degradation of the microbial invader (PubMed:34012115). Involved in lipid metabolism by regulating fat storage and lipid droplet formation; act by inhibiting the lipolytic process (PubMed:30705059). Also regulates lipotoxicity by inhibiting desaturation of fatty acids (PubMed:30846318). Also acts as an E3 ubiquitin-protein ligase via its RING-type zinc finger: mediates 'Lys-63'-linked ubiquitination of target proteins (PubMed:32139119, PubMed:33842849). Involved in the non-canonical Wnt signaling pathway in vascular development: acts by mediating ubiquitination and degradation of FLNA and NFATC2 downstream of RSPO3, leading to inhibit the non-canonical Wnt signaling pathway and promoting vessel regression (PubMed:26766444). Also has ATPase activity; ATPase activity is required for ubiquitination of LPS (PubMed:34012115).
catalytic activity: S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
catalytic activity: ATP + H2O = ADP + H(+) + phosphate (RHEA:13065)
subunit: Monomer (By similarity). Interacts with UBE2L3/UBCH7; UBE2L3/UBCH7 is the most efficient ubiquitin-conjugating enzyme E2 for the ubiquitin ligase activity (By similarity). Interacts with UBE2N/UBC13; promoting 'Lys-63'-linked ubiquitination of target proteins (PubMed:32139119, PubMed:33842849).
subunit: (Microbial infection) Interacts with M.tuberculosis protein Rv3655c, which impairs caspase-8 activation and suppresses macrophage apoptosis by blocking the extrinsic pathway. - Adipocytes reprogram the proteome of breast cancer cells in organotypic three-dimensional cell cultures
Tovar-Hernández, Scientific reports 2024 - Ligandability of E3 Ligases for Targeted Protein Degradation Applications.
Belcher, Biochemistry 2023 - “...C320 *** RNF149 Q8NC42 C295 *** RNF167 Q9H6Y7 C271 *** RNF180 Q86T96 C28 *** RNF213 Q63HN8 C614 *** UBR1 Q8IWV7 C180, C1603 *** UBR2 Q8IWV8 C1360, C1619 *** , C576 UBR4 Q5T4S7 C1358, C2554 *** , C4049, C2222, C1274 ZNF598 Q86UK7 C456 *** KCTD21 Q4G0X4 C166...”
- RNF213 loss-of-function promotes pathological angiogenesis in moyamoya disease via the Hippo pathway.
Ye, Brain : a journal of neurology 2023 - “...the three-frame translation. ( B ) The protein structure of the wild-type (WT) RNF213 protein (Q63HN8) was modelled with 100.0% confidence based on the single highest-scoring template of the well-known mouse Rnf213 (c7oikA). The benign CNV deletion of RNF213 showed a high identity (99.42%) with WT,...”
- Count Dracula Resurrected: Proteomic Analysis of Vlad III the Impaler's Documents by EVA Technology and Mass Spectrometry.
Pittalà, Analytical chemistry 2023 - “...Q9H2U2 inorganic pyrophosphatase 2, mitochondrial EENGIPMKK M ox pGlu low tissue specificity YES x RNF213 Q63HN8 E3 ubiquitin-protein ligase RNF213 WQKSIVEELCAWVEKFINVK W ox-ky W oxolactone low tissue specificity YES x ROBO4 Q8WZ75 roundabout homolog4 MGSGGDSLLGGR acetyl (protein N-term)M ox adipose tissue YES x ROPN1L Q96C74 ropporin-1-like...”
- The Protective Action of Metformin against Pro-Inflammatory Cytokine-Induced Human Islet Cell Damage and the Mechanisms Involved.
Giusti, Cells 2022 - “...Q8N339 METALLOTHIONEIN-1M (PTHR23299:SF50) MT1M 3.11 2.49 Q09666 NEUROBLAST DIFFERENTIATION-ASSOCIATED PROTEIN AHNAK (PTHR23348:SF41) AHNAK 9.48 0.31 Q63HN8 E3 UBIQUITIN-PROTEIN LIGASE RNF213 (PTHR22605:SF16) RNF213 10.35 8.25 O95786 ATP-DEPENDENT RNA HELICASE DDX58-RELATED (PTHR14074:SF16) DDX58 11.21 10.63 P69905 HEMOGLOBIN SUBUNIT ALPHA (PTHR11442:SF48) HBA1 23.19 34.96 Q13113 PDZK1-INTERACTING PROTEIN 1 (PTHR15296:SF0)...”
- Identification of HO-1 as a novel biomarker for graft acute cellular rejection and prognosis prediction after liver transplantation
Jia, Annals of translational medicine 2020 - “...AK1 1.448 Q9GZP4 PITH domain containing 1 PITHD1 1.444 P27348 14-3-3 protein theta YWHAQ 1.436 Q63HN8 Ring finger protein 213 RNF213 1.435 P53004 Biliverdin reductase A BLVRA 1.432 P52907 F-actin-capping protein subunit alpha-1 CAPZA1 1.431 Q99873 Protein arginine methyltransferase 1 PRMT1 1.431 O00151 PDZ and LIM...”
- Proteomic profile of follicular fluid from patients with polycystic ovary syndrome (PCOS) submitted to in vitro fertilization (IVF) compared to oocyte donors
Domingues, JBRA assisted reproduction 2019 - “...NA NA 1 Q53GS7 Nucleoporin GLE1 nucleic acid binding(PC00171);transfer/carrier protein(PC00219) nucleic acid binding(GO:0005488) NA 1 Q63HN8 E3 ubiquitin-protein ligase RNF213 NA NA NA 1 Q6YP21 Kynurenine--oxoglutarate transaminase 3 transaminase(PC00220) transaminase activity(GO:0003824) NA 1 Q70CQ2 Ubiquitin carboxyl-terminal hydrolase 34 NA NA NA 1 Q7Z6M1 Rab9 effector protein...”
- SAMHD1 Enhances Chikungunya and Zika Virus Replication in Human Skin Fibroblasts.
Wichit, International journal of molecular sciences 2019 - “...LAP3 P28838 1.049 Interferon-induced 35 kDa protein IFI35 P80217 1.015 E3 ubiquitin-protein ligase RNF213 RNF213 Q63HN8 0.895 Gamma-interferon-inducible protein 16 IFI16 Q16666 0.878 Double-stranded RNA-activated protein kinase EIF2AK2 * P19525 0.838 HLA class I histocompatibility antigen, A-69 alpha chain HLA-A P10316 0.752 Zika virus infected cells...”
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F1M0R1 Ring finger protein 213 from Rattus norvegicus
Aligns to 4415:4469 / 5126 (1.1%), covers 81.5% of PF20173, 67.8 bits
XP_038943469 E3 ubiquitin-protein ligase RNF213 isoform X1 from Rattus norvegicus
Aligns to 4490:4544 / 5201 (1.1%), covers 81.5% of PF20173, 67.8 bits
DDB_G0278761 NF-X1-type zinc finger-containing protein from Dictyostelium discoideum AX4
Aligns to 1717:1772 / 1793 (3.1%), covers 96.3% of PF20173, 67.2 bits
XP_006534693 E3 ubiquitin-protein ligase RNF213 isoform X1 from Mus musculus
Aligns to 4480:4535 / 5192 (1.1%), covers 85.2% of PF20173, 66.8 bits
- RNF213 loss-of-function promotes pathological angiogenesis in moyamoya disease via the Hippo pathway.
Ye, Brain : a journal of neurology 2023 - GeneRIF: RNF213 loss-of-function promotes pathological angiogenesis in moyamoya disease via the Hippo pathway.
- Rnf-213 Knockout Induces Pericyte Reduction and Blood-Brain Barrier Impairment in Mouse.
Li, Molecular neurobiology 2023 (PubMed)- GeneRIF: Rnf-213 Knockout Induces Pericyte Reduction and Blood-Brain Barrier Impairment in Mouse.
- Knockout of Rnf213 Ameliorates Cerebral Ischemic-reperfusion Injury by Inhibiting Neuronal Apoptosis Through the Akt/GSK-3β/β-catenin/Bcl-2 Pathway.
Li, Neuroscience 2023 (PubMed)- GeneRIF: Knockout of Rnf213 Ameliorates Cerebral Ischemic-reperfusion Injury by Inhibiting Neuronal Apoptosis Through the Akt/GSK-3beta/beta-catenin/Bcl-2 Pathway.
- Suppression of RNF213, a susceptibility gene for moyamoya disease, inhibits endoplasmic reticulum stress through SEL1L upregulation.
Ahmed, Biochemical and biophysical research communications 2022 (PubMed)- GeneRIF: Suppression of RNF213, a susceptibility gene for moyamoya disease, inhibits endoplasmic reticulum stress through SEL1L upregulation.
- Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism.
Ahel, eLife 2020 - GeneRIF: Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism.
- S-nitrosylation of E3 ubiquitin-protein ligase RNF213 alters non-canonical Wnt/Ca+2 signaling in the P301S mouse model of tauopathy.
Amal, Translational psychiatry 2019 - GeneRIF: Study shows that S-nitrosylation of E3 ubiquitin-protein ligase RNF213 alters non-canonical Wnt/Ca+2 signaling in the P301S mouse model of tauopathy.
- Dysregulation of RNF213 promotes cerebral hypoperfusion.
Morimoto, Scientific reports 2018 - GeneRIF: results are indicative of the essential role of RNF213 in the maintenance of cerebral blood flow .
- Transient middle cerebral artery occlusion in mice induces neuronal expression of RNF213, a susceptibility gene for moyamoya disease.
Sato-Maeda, Brain research 2016 (PubMed)- GeneRIF: The Rnf213 gene was up-regulated in the ischemic brain, especially at the penumbra area, as early as 6 h after transient middle cerebral artery occlusion
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RN213_MOUSE / E9Q555 E3 ubiquitin-protein ligase RNF213; E3 ubiquitin-lipopolysaccharide ligase RNF213; Mysterin; RING finger protein 213; EC 2.3.2.27; EC 3.6.4.-; EC 2.3.2.- from Mus musculus (Mouse) (see 6 papers)
Aligns to 4436:4491 / 5148 (1.1%), covers 85.2% of PF20173, 66.8 bits
- function: Atypical E3 ubiquitin ligase that can catalyze ubiquitination of both proteins and lipids, and which is involved in various processes, such as lipid metabolism, angiogenesis and cell-autonomous immunity (PubMed:32573437). Acts as a key immune sensor by catalyzing ubiquitination of the lipid A moiety of bacterial lipopolysaccharide (LPS) via its RZ-type zinc-finger: restricts the proliferation of cytosolic bacteria, such as Salmonella, by generating the bacterial ubiquitin coat through the ubiquitination of LPS (PubMed:34012115). Also acts indirectly by mediating the recruitment of the LUBAC complex, which conjugates linear polyubiquitin chains (By similarity). Ubiquitination of LPS triggers cell-autonomous immunity, such as antibacterial autophagy, leading to degradation of the microbial invader (By similarity). Involved in lipid metabolism by regulating fat storage and lipid droplet formation; act by inhibiting the lipolytic process (By similarity). Also regulates lipotoxicity by inhibiting desaturation of fatty acids (By similarity). Also acts as an E3 ubiquitin-protein ligase via its RING-type zinc finger: mediates 'Lys- 63'-linked ubiquitination of target proteins (By similarity). Involved in the non-canonical Wnt signaling pathway in vascular development: acts by mediating ubiquitination and degradation of FLNA and NFATC2 downstream of RSPO3, leading to inhibit the non-canonical Wnt signaling pathway and promoting vessel regression (By similarity). Also has ATPase activity; ATPase activity is required for ubiquitination of LPS (PubMed:32573437).
catalytic activity: S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
catalytic activity: ATP + H2O = ADP + H(+) + phosphate (RHEA:13065)
subunit: Monomer (PubMed:32573437). Interacts with UBE2L3/UBCH7; UBE2L3/UBCH7 is the most efficient ubiquitin-conjugating enzyme E2 for the ubiquitin ligase activity (PubMed:32573437). Interacts with UBE2N/UBC13; promoting 'Lys-63'-linked ubiquitination of target proteins (By similarity).
disruption phenotype: No visible phenotype (PubMed:23410753, PubMed:24440776). Males and female are fertile and produce normal-sized litters (PubMed:23410753, PubMed:24440776). Mice do not spontaneously develop Moyamoya disease, a chronic occlusive cerebrovascular disease (PubMed:24440776). Mice are however more susceptible to Rift Valley fever virus infection (PubMed:33420513). Mice show elevated expression of MMP9 (PubMed:25383461). - The Proteomic Signature of Intestinal Acute Rejection in the Mouse.
Oltean, Metabolites 2021 - “...2.38 Antimicrobial Inflammatory response Q99KQ4 Nampt Nicotinamide phosphoribosyltransferase 2.12 Cytokine, Glycosyltransferase Cell death and survival E9Q555 Rnf213 E3 ubiquitin-protein ligase RNF213 1.82 Hydrolase, Transferase Angiogenesis P01899 H2-d1 H-2 class I histocompatibility antigen, D-B alpha chain 1.69 Binding protein Immunology Q9R233 Tapbp Tapasin 1.59 Binding protein Immunology...”
- Quantitative Proteomics Reveals Docosahexaenoic Acid-Mediated Neuroprotective Effects in Lipopolysaccharide-Stimulated Microglial Cells
Yang, Journal of proteome research 2020 - “...cell nuclear differentiation antigen-like protein MNDAL 2.67 n.d. 3.25 Q64337 sequestosome-1 SQSTM1 1.86 0.22 2.02 E9Q555 E3 ubiquitin-protein ligase RNF213 1.66 2.01 2.03 Q8VI94 2-5-oligoadenylate synthase-likeprotein1 OASL1 1.54 1 1.94 Increased in DHA, Lower/Unchanged in LPS Q3UH60 disco-interacting protein 2-B DIP2B n.d. 2.43* n.d. Q91W86 vacuolar...”
- iTRAQ‑based proteomic analysis of endotoxin tolerance induced by lipopolysaccharide
Zhang, Molecular medicine reports 2019 - “...1.363 20 Q9Z0J0 Npc2 Epididymal secretory protein E1 1.362 21 Q9JHK5 Plek Pleckstrin 1.336 22 E9Q555 Rnf213 E3 ubiquitin-protein ligase RNF213 1.328 23 D0QMC3 Mndal Myeloid cell nuclear differentiation antigen-like protein 1.327 24 P20108 Prdx3 Thioredoxin-dependent peroxide reductase, mitochondrial 1.304 25 P97429 Anxa4 Annexin A4 1.298...”
- The ubiquitin ligase Cullin5SOCS2 regulates NDR1/STK38 stability and NF-κB transactivation
Paul, Scientific reports 2017 - “...3.285 1.189 12 169.43 Q8BW84 Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial Pet112 3.543 1.180 5 61.509 E9Q555 E3 ubiquitin-protein ligase RNF213 Rnf213 2.675 1.138 18 584.49 Q8R5C5 Beta-centractin Actr1b 1.997 1.098 6 42.281 Q9DCJ5 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 Ndufa8 3.935 1.098 5 19.992...”
- iTRAQ protein profile analysis of neuroblastoma (NA) cells infected with the rabies viruses rHep-Flury and Hep-dG.
Yang, Frontiers in microbiology 2015 - “...3 1.375 0.026 Ddx58 protein Ddx58 A1L0V6 2 1.378 0.034 E3 ubiquitin-protein ligase RNF213 Rnf213 E9Q555 16 1.391 0.044 Signal transducer and activator of transcription 3 Stat3 Q6GU23 2 1.415 0.017 mRNA H2-D1 Q61892 1 1.454 0.046 Discoidin domain-containing receptor 2 Ddr2 Q62371 2 1.490 0.053...”
- Quantitative phosphoproteomics reveals crosstalk between phosphorylation and O-GlcNAc in the DNA damage response pathway.
Zhong, Proteomics 2015 - “...1.7 Ranbp3 Ran-binding protein 3 Q9CT10 S283 2.4 T56 2.4 Rnf213 E3 ubiquitin-protein ligase RNF213 E9Q555 T46 3.3 Rragc Ras-related GTP-binding protein C Q99K70 S94 1.9 T95 2.1 Sept9 Septin-9 Q80UG5 S30 1.8 Snrnp70 U1 small nuclear ribonucleoprotein 70 kDa Q62376 S408 7.6 Trim28 Transcription intermediary...”
- Comparative proteomic analysis identifies age-dependent increases in the abundance of specific proteins after deletion of the small heat shock proteins αA- and αB-crystallin.
Andley, Biochemistry 2013 - “...6171 catenin -1, Q02248 8 85 1.12 3.27 3.65 MCG140784, Q792Z1 4 26 Uncharacterized protein, E9Q555 4 584 -1-antitrypsin 14, Q00897 3 46 Nesprin-1, Q6ZWR6 3 1010 Liver carboxylesterase N, P23953 3 61 Alpha-2-macroglobulin, Q61838 2 166 Glutamate dehydrogenase 1, mitochondrial P26443 2 61 6278 Histone...”
E1BHN4 Ring finger protein 213 from Bos taurus
Aligns to 4293:4348 / 5005 (1.1%), covers 85.2% of PF20173, 65.0 bits
R213B_DANRE / A0A0R4I9Y1 E3 ubiquitin-protein ligase rnf213-beta; E3 ubiquitin-lipopolysaccharide ligase rnf213-beta; Mysterin-B; Mysterin-beta; RING finger protein 213-B; RING finger protein 213-beta; EC 2.3.2.27; EC 3.6.4.-; EC 2.3.2.- from Danio rerio (Zebrafish) (Brachydanio rerio) (see 2 papers)
Aligns to 4437:4491 / 5061 (1.1%), covers 85.2% of PF20173, 58.3 bits
- function: Atypical E3 ubiquitin ligase that can catalyze ubiquitination of both proteins and lipids, and which is involved in various processes, such as lipid metabolism, angiogenesis and cell-autonomous immunity. Acts as a key immune sensor by catalyzing ubiquitination of the lipid A moiety of bacterial lipopolysaccharide (LPS) via its RZ- type zinc-finger: restricts the proliferation of cytosolic bacteria, such as Salmonella, by generating the bacterial ubiquitin coat through the ubiquitination of LPS. Ubiquitination of LPS triggers cell- autonomous immunity, such as antibacterial autophagy, leading to degradation of the microbial invader (By similarity). Involved in lipid metabolism by regulating fat storage and lipid droplet formation; act by inhibiting the lipolytic process (By similarity). Also regulates lipotoxicity by inhibiting desaturation of fatty acids. Also acts as an E3 ubiquitin-protein ligase via its RING-type zinc finger. Involved in the non-canonical Wnt signaling pathway in vascular development: acts by mediating ubiquitination and degradation of proteins downstream of rspo3, leading to inhibit the non-canonical Wnt signaling pathway and promoting vessel regression. Also has ATPase activity; ATPase activity is required for ubiquitination of LPS (By similarity).
catalytic activity: S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
catalytic activity: ATP + H2O = ADP + H(+) + phosphate (RHEA:13065)
disruption phenotype: No visible phenotype (PubMed:21799892, PubMed:26530008). No vascular phenotype (PubMed:21799892, PubMed:26530008).
Or search for genetic data about PF20173 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory