PaperBLAST

PaperBLAST Hits for HBBA_CATCL / P85312 (42 a.a., VEWTDAERSA...)

Show query sequence

>HBBA_CATCL / P85312
VEWTDAERSAILSLWGKIDTDELGPALLARLXLVXXXTQRYF

Running BLASTp...

Found 225 similar proteins in the literature:

HBBA_CATCL / P85312 Hemoglobin subunit beta-A; Beta-A-globin; Hemoglobin beta-A chain from Catostomus clarkii (Desert sucker) (see paper)
100% identity, 100% coverage

• function: Involved in oxygen transport from gills to the various peripheral tissues.
  subunit: Heterotetramer of two alpha chains and two beta chains.

HBBB_CATCL / P85313 Hemoglobin subunit beta-B; Beta-B-globin; Hemoglobin beta-B chain from Catostomus clarkii (Desert sucker) (see paper)
90% identity, 88% coverage

• function: Involved in oxygen transport from gills to the various peripheral tissues.
  subunit: Heterotetramer of two alpha chains and two beta chains.

O13140 Beta-globin from Cyprinus carpio
69% identity, 28% coverage

• Properties of peptides released from salmon and carp via simulated human-like gastrointestinal digestion described applying quantitative parameters
  Borawska-Dziadkiewicz, PloS one 2021
  • “...Q90335), carp sarcoplasmic proteins (P09227, P02618, Q8UUS3, Q8UUS2, P02204, Q2LC33, Q8UW95, Q8UW92, O13135, Q8UW94, Q8UW93, O13140), and other carp proteins (P02016, P02139, Q7ZZH6, Q7T276). Methods The workflow of the conducted analyses is shown in Fig 1 . 10.1371/journal.pone.0255969.g001 Fig 1 Workflow of conducted research. Profiles of...”
  • “...(B9ENY2) 0.3231 collagen (C0H9S7) 0.0055 HSP (B5DG30) 0.0592 MHC (Q2HX57) 0.0029 MLC (Q90333) 0.034 -globin (O13140) 0.0053 parvalbumin (Q8UUS3) 0.0338 hemoglobin (P02139) 0.0055 HSP (Q7T276) Antioxidant peptides a 39 myosin (A8WCK1) 3 MLC (B5DGT2) 7 parvalbumin (Q91482) 2 parvalbumin (B5X6D1) 53 collagen (A7KE05) 1 HSP (B5XBY4)...”

B0BL35 Hemoglobin beta from Carassius auratus
69% identity, 28% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P02125 P04246 P07414 P08853 B0BL34 P01924 P01958 P01990 P02020 P02058 P02093 P02126 P04252 P07415 P09105 B0BL35 P01926 P01959 P01991 P02021 P02059 P02094 P02127 P04346 P07417 P09420 B1H216 P01928 P01960 P01992 P02022 P02060 P02095 P02128 P04442 P07419 P09421 B1Q450 P01929 P01961 P01993 P02024 P02061 P02097 P02129 P04443...”

P02140 Hemoglobin subunit beta from Carassius auratus
69% identity, 29% coverage

• Metallomic Approach to Mercury and Selenium in the Liver Tissue of Psectrogaster amazonica and Raphiodon vulpinus from the Brazilian Amazon.
  Bataglioli, International journal of molecular sciences 2024
  • “...C Hg (mg kg 1 ) C Se (mg kg 1 ) P. amazonica 59 P02140 P02018 Hemoglobin subunit beta Hemoglobin subunit alpha 2527.965 188.4514 9.700 0.1400 16.15 0.2100 60 P02017 P02140 P80856 Hemoglobin subunit alpha Hemoglobin subunit beta Fatty acid-binding protein_ liver 2305.963 1368.896 1131.812...”
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P02003 P02036 P02075 P02108 P02139 P06643 P08223 P0C0U6 O13163 P01941 P01973 P02004 P02038 P02076 P02109 P02140 P07034 P08224 P0C0U7 O13164 P01942 P01975 P02005 P02039 P02077 P02110 P02141 P07035 P08225 P0C0U8 10.1371/journal.pone.0009550.t003 Table 3 SwissProt/UniProt Accession Numbers for Hemoglobin dataset Part 2. P0C237 P14524 P20018 P41327 P67822...”

B5X8L0 Hemoglobin subunit beta from Salmo salar
69% identity, 28% coverage

• Properties of peptides released from salmon and carp via simulated human-like gastrointestinal digestion described applying quantitative parameters
  Borawska-Dziadkiewicz, PloS one 2021
  • “...Q91483, B5X6D1, B9ENR7, B9EPT7, B5X603, B9ENY2), other salmon proteins (C0H9S7, B5X659, C1K2L7, A7KE05, C0H805, B5X746, B5X8L0, C0H744, P21848, C0HBF1, B5X4Z3, B5XDG3, B9EQI5, B5DG30, B5XBY4, B5DGI9, C0HAB6, B9EM16, Q9W6K6), carp myofibrillar proteins (P53479, P83750, Q6TKP4, Q6TKP5, Q7T2J3, Q90339, Q2HX57, Q2HX56, Q5NTZ3, Q90337, O42352, Q2HX58, Q90331, Q90332, Q90333,...”
  • “...(A8WCK1) 48 myosin (B9ELW1) 88 myoglobin (B9ENY2) 52 parvalbumin (B9EPT7) 1943 collagen (A7KE05) 93 hemoglobin (B5X8L0) 933 MHC (Q5NTZ3) 32 meromyosin (Q90335) 106 myoglobin (P02204) 60 parvalbumin (P09227, Q8UUS2, Q8UUS3) 401 HSP (Q7ZZH6) 99 hemoglobin (P02016) A 0.6373 MLC (B5DGT1) 0.3551 myosin fr. (C0PU27) 0.6667 myoglobin...”

HBB_CYPCA / P02139 Hemoglobin subunit beta-A/B; Hemoglobin beta-A/B chain; Hemoglobin subunit beta-1/2 from Cyprinus carpio (Common carp) (see paper)
67% identity, 29% coverage

• function: Involved in oxygen transport from gills to the various peripheral tissues
  subunit: Heterotetramer of two alpha chains and two beta chains
• Properties of peptides released from salmon and carp via simulated human-like gastrointestinal digestion described applying quantitative parameters
  Borawska-Dziadkiewicz, PloS one 2021
  • “...Q8UUS3, Q8UUS2, P02204, Q2LC33, Q8UW95, Q8UW92, O13135, Q8UW94, Q8UW93, O13140), and other carp proteins (P02016, P02139, Q7ZZH6, Q7T276). Methods The workflow of the conducted analyses is shown in Fig 1 . 10.1371/journal.pone.0255969.g001 Fig 1 Workflow of conducted research. Profiles of the potential biological activity, and A,...”
  • “...(B5DGI9) 0.6321 MLC (Q90332) 0.4503 MLC (Q90333) 0.7273 -globin (O13135) 0.5139 -globin (Q8UW92) 0.7063 hemoglobin (P02139) 0.4768 HSP (Q7ZZH6) ACE inhibitory peptides a 199 myosin (A8WCK1) 27 myosin (B9ELW1) 50 myoglobin (B9ENY2) 33 parvalbumin (B9EPT7) 969 collagen (A7KE05) 49 hemoglobin (B5X746) 646 MHC (Q5NTZ3) 23 meromyosin...”
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P02002 P02035 P02074 P02107 P02138 P06642 P08054 P09909 O13078 P01940 P01972 P02003 P02036 P02075 P02108 P02139 P06643 P08223 P0C0U6 O13163 P01941 P01973 P02004 P02038 P02076 P02109 P02140 P07034 P08224 P0C0U7 O13164 P01942 P01975 P02005 P02039 P02077 P02110 P02141 P07035 P08225 P0C0U8 10.1371/journal.pone.0009550.t003 Table 3 SwissProt/UniProt Accession...”

Q98TS0 Hemoglobin subunit beta from Oncorhynchus nerka
67% identity, 28% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P68048 P69892 P84652 Q45V70 Q78PA4 Q98905 P11750 P18981 P23019 P61772 P68049 P69905 P84653 Q45XH3 Q7JFN6 Q98TS0 P11751 P18982 P23020 P61773 P68050 P69906 P84790 Q45XH5 Q7JFR7 Q9AWA9 P11752 P18983 P23600 P61774 P68051 P69907 P84791 Q45XH6 Q7LZB9 Q9CWS5 P11753 P18984 P23601 P61775 P68052 P80043 P84792 Q45XH7 Q7LZC1 Q9CY06...”

Q91473 Hemoglobin subunit beta from Salmo salar
67% identity, 28% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P68022 P68236 P83623 Q2MHE0 Q6WN20 Q90ZM4 P10783 P17689 P21380 P51443 P68023 P68237 P83624 Q2PAD4 Q6WN21 Q91473 P10784 P18435 P21667 P51465 P68024 P68238 P83625 Q3C1F3 Q6WN22 Q941P9 P10785 P18436 P21668 P55267 P68025 P68239 P84203 Q3C1F4 Q6WN25 Q941Q1 P10786 P18707 P21766 P56250 P68026 P68240 P84204 Q3MQ26 Q6WN26 Q946U7...”

LOC100704059 hemoglobin subunit beta-A from Oreochromis niloticus
69% identity, 28% coverage

• Comparative transcriptome analysis reveals a serotype-specific immune response in Nile tilapia (Oreochromis niloticus) infected with Streptococcus agalactiae
  Appel, Frontiers in immunology 2024
  • “...homeobox 5 -2.45 ( 0.37) LOC102080222 hemoglobin subunit alpha-B -3.91 ( 0.17) -2.86 ( 0.16) LOC100704059 hemoglobin subunit beta-A -4.09 ( 0.17) -3.03 ( 0.16) The comparison between Nile tilapia exposed to the SA8-UEL strain with those exposed to the SA10-UEL strain revealed distinct patterns in...”

3bomB / P02141 Crystal structure of trout hemoglobin at 1.35 angstrom resolution
67% identity, 29% coverage

• Ligand: protoporphyrin ix containing fe (3bomB)

HBB2_DANRE / Q90485 Hemoglobin subunit beta-2; Beta-2-globin; Beta-A2-globin; Hemoglobin beta-2 chain from Danio rerio (Zebrafish) (Brachydanio rerio) (see paper)
64% identity, 28% coverage

• function: Involved in oxygen transport from gills to the various peripheral tissues
  subunit: Heterotetramer of two alpha chains and two beta chains.
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P68231 P83611 Q28932 Q6QDC2 Q8QG65 Q9Y0D5 P10778 P15469 P21199 P51438 P68019 P68232 P83612 Q29415 Q6R7N2 Q90485 Q9Y0E6 P10780 P16309 P21200 P51440 P68020 P68234 P83613 Q2KPA3 Q6S9E2 Q90486 Q9YGW1 P10781 P16417 P21201 P51441 P68021 P68235 P83614 Q2KPA4 Q6T497 Q90487 Q9YGW2 P10782 P16418 P21379 P51442 P68022 P68236 P83623...”

HBB1_DANRE / Q90486 Hemoglobin subunit beta-1; Beta-1-globin; Beta-A1-globin; Hemoglobin beta-1 chain from Danio rerio (Zebrafish) (Brachydanio rerio) (see paper)
B3DG37 Ba1 protein from Danio rerio
64% identity, 28% coverage

• function: Involved in oxygen transport from gills to the various peripheral tissues
  subunit: Heterotetramer of two alpha chains and two beta chains.
• Proteomic analysis of zebrafish caudal fin regeneration
  Saxena, Molecular & cellular proteomics : MCP 2012
  • “...8 NA Q90486 D10 D7 D3 D9 gI-32442452 Q7SYH6 D16 3 NA gI-18858329 B3DG37 D12 2 -1.62 -1.72 -1.83 -2.07 -2.08 -2.11 -2.35 -2.53 D D D D D D D D 0/1 0/1 0/1 0/1...”
• Orthosiphon stamineus Proteins Alleviate Pentylenetetrazol-Induced Seizures in Zebrafish
  Chung, Biomedicines 2020
  • “...five proteins, namely hemoglobin subunit alpha (Hbaa1, isoforms Q803Z5 and Q90487), hemoglobin subunit beta-1 (Hbba1, Q90486), fructose-bisphosphate aldolase C-B (Aldocb, Q8JH70), actin beta 2 (Actb2, A8WG05), and complexin 2 (Cplx2, E7FBR8) were found expressed at higher levels. 3.2.6. Bioinformatics Analysis The differentially expressed proteins ( Table...”
  • “...4 15,524 0.00:1.00 Hbaa1 Q803Z5 Hemoglobin subunit alpha 200 49 12 4 15,508 1.00:255.14 Hbaa1 Q90486 Hemoglobin subunit beta-1 200 43 8 8 16,389 1.00:49.49 Hbba1 Q08BA1 ATP synthase subunit alpha 200 15 6 3 59,744 0.00:1.00 Atp5fa1 Q6PC12 Enolase 1 200 12 4 3 47,074...”
• A Placenta Derived C-Terminal Fragment of β-Hemoglobin With Combined Antibacterial and Antiviral Activity
  Groß, Frontiers in microbiology 2020
  • “...; Meleagris gallopavo (Common turkey) P81023 ; Gallus gallus (Chicken) P02112 ; Danio rerio (Zebrafish) Q90486 ; Protein sequences were aligned using Clustal W 3 and residue conservation was determined using the Scorecons Server 4 . Shannons information theoretical entropy was applied to measure the diversity...”
• Molecular evolution of globin genes in Gymnotiform electric fishes: relation to hypoxia tolerance
  Tian, BMC evolutionary biology 2017
  • “...relative to Zebrafish ( Danio rerio ) protein sequences, i.e., Mb (Q6VN46), Hba (Q90487), Hbb (Q90486), and Ngb (Q90YJ2) in UniProtKB To test for positive selection along particular branches, we used the one-ratio model (M0) that allows only a single ratio for all branches. The ratio...”
  • “...to Zebrafish ( Danio rerio ) protein sequences, i.e., Mb (Q6VN46), Hba (Q90487), and Hbb (Q90486) in UniProtKB. Codons identified as under positive selection more than one ML methods. Positively selected sites detected by Datamonkey are represented in underlined letters b Amino acid substitution occurred along...”
• Quantitative proteomics analysis of zebrafish exposed to sub-lethal dosages of β-methyl-amino-L-alanine (BMAA)
  Frøyset, Scientific reports 2016
  • “...x transcription regulation Q7ZUG5 rps21 n.d. 40S ribosomal protein S21 3 8.9 x x translation Q90486 ba1;ba2 n.d. Hemoglobin subunit beta 2 16.4 x oxygen transport, transport Fold regulation shows BMAA/control. Proteins only detected in triplicates of either BMAA or control have fold regulation not detemined...”
• Proteomic analysis of zebrafish caudal fin regeneration
  Saxena, Molecular & cellular proteomics : MCP 2012
  • “...B5WY15 D21 gI-55962880 Q5SPF0 gI-189522994 4 5 6 7 8 NA Q90486 D10 D7 D3 D9 gI-32442452 Q7SYH6 D16 3 NA gI-18858329 B3DG37 D12 2 -1.62 -1.72 -1.83 -2.07 -2.08...”
  • “...24 Q6P3L0 4D45-2.91 F1R3G8 4D28-3.25 Q6ZM17 4D4 -3.51 Q90487 4D3 -5.12 Q90486 4D5 -4.56 A4QN86 4D38-4.13 Q9PUB5 U24 2.88,4.27 Q1LXJ0 Q1LXJ0 D D D D D D D D D D...”
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P68232 P83612 Q29415 Q6R7N2 Q90485 Q9Y0E6 P10780 P16309 P21200 P51440 P68020 P68234 P83613 Q2KPA3 Q6S9E2 Q90486 Q9YGW1 P10781 P16417 P21201 P51441 P68021 P68235 P83614 Q2KPA4 Q6T497 Q90487 Q9YGW2 P10782 P16418 P21379 P51442 P68022 P68236 P83623 Q2MHE0 Q6WN20 Q90ZM4 P10783 P17689 P21380 P51443 P68023 P68237 P83624 Q2PAD4...”

Q5I122 Hemoglobin beta chain from Sciaenops ocellatus
67% identity, 28% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P29628 P67815 P68071 P82316 Q1AGS6 Q5GLZ7 Q7T1B0 Q9PVM3 P14391 P19760 P30892 P67816 P68077 P82345 Q1AGS7 Q5I122 Q7Y079 Q9PVM4 P14392 P19789 P30893 P67817 P68078 P82990 Q1AGS8 Q5KSB7 Q7Y1Y1 Q9PVU6 P14520 P19831 P33499 P67818 P68079 P83114 Q1AGS9 Q5MD69 Q7ZT21 Q9TS34 P14521 P19832 P41260 P67819 P68087 P83123 Q1W6G9 Q5RM02...”

P02141 Hemoglobin subunit beta-4 from Oncorhynchus mykiss
LOC100136291 hemoglobin subunit beta-4 from Oncorhynchus mykiss
64% identity, 28% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P02004 P02038 P02076 P02109 P02140 P07034 P08224 P0C0U7 O13164 P01942 P01975 P02005 P02039 P02077 P02110 P02141 P07035 P08225 P0C0U8 10.1371/journal.pone.0009550.t003 Table 3 SwissProt/UniProt Accession Numbers for Hemoglobin dataset Part 2. P0C237 P14524 P20018 P41327 P67822 P68194 P83132 Q27940 Q6AW44 Q8AXX7 Q9TSN9 P0C238 P14525 P20019 P41328 P67823...”
• Generation of a large scale repertoire of Expressed Sequence Tags (ESTs) from normalised rainbow trout cDNA libraries
  Govoroun, BMC genomics 2006
  • “...alpha sarcomeric/cardiac (Actin alpha 2) No BX073087.1.p.om.3 431 P21993 Prolactin precursor (PRL) No CA342041.1.p.om.3 402 P02141 Hemoglobin beta-4 subunit No CA369471.1.p.om.3 389 P30042 ES1 protein homolog, mitochondrial precursor (Protein KNP-I) Yes (Pooled-Tissue) CA368365.1.p.om.3 342 P35031 Trypsin I precursor Yes (Pooled-Tissue) BX074651.1.p.om.3 314 P20332 Somatotropin 2 precursor...”
• Efficacy of DNA Vaccines in Protecting Rainbow Trout against VHS and IHN under Intensive Farming Conditions
  Marsella, Vaccines 2022
  • “...set for the endogenous gene targeted two different exons of the Oncorhynchus mykiss beta-globin gene (LOC100136291). Primer sets were designed using the Primer3web version 4.1.0 ( https://primer3.ut.ee/ (accessed on 29 September 2022)) and are specified in Table 3 . PCR amplifications were performed with the Platinum...”

Q5MD69 Beta hemoglobin from Larimichthys crocea
64% identity, 28% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P30893 P67817 P68078 P82990 Q1AGS8 Q5KSB7 Q7Y1Y1 Q9PVU6 P14520 P19831 P33499 P67818 P68079 P83114 Q1AGS9 Q5MD69 Q7ZT21 Q9TS34 P14521 P19832 P41260 P67819 P68087 P83123 Q1W6G9 Q5RM02 Q803Z5 Q9TS35 P14522 P19885 P41261 P67820 P68168 P83124 Q26505 Q5XLE5 Q862A7 Q9TSN7 P14523 P19886 P41262 P67821 P68169 P83131 Q27126 Q67XG0...”

Q4F6Z2 Hemoglobin beta B chain from Sciaenops ocellatus
64% identity, 28% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P24660 P62742 P68060 P80946 Q10732 Q45XJ0 Q7M2Y5 Q9GJS7 P13557 P18995 P26915 P63105 P68061 P81023 Q10733 Q4F6Z2 Q7M3B6 Q9GLX4 P13558 P18996 P26916 P63106 P68062 P81024 Q17153 Q4VIX3 Q7M3B8 Q9I9I3 P14259 P19002 P28780 P63107 P68063 P81042 Q17155 Q53I65 Q7M3C2 Q9M3U9 P14260 P19014 P28781 P63108 P68064 P81043 Q17156 Q549D9...”

Q9PVM1 Hemoglobin subunit beta-B from Seriola quinqueradiata
64% identity, 28% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P68068 P82112 Q17286 Q58L97 Q7M419 Q9PRL9 P14388 P19645 P29625 P63111 P68069 P82113 Q1AGS4 Q5BLF6 Q7M421 Q9PVM1 P14389 P19646 P29626 P63112 P68070 P82315 Q1AGS5 Q5GLZ6 Q7M422 Q9PVM2 P14390 P19759 P29628 P67815 P68071 P82316 Q1AGS6 Q5GLZ7 Q7T1B0 Q9PVM3 P14391 P19760 P30892 P67816 P68077 P82345 Q1AGS7 Q5I122 Q7Y079 Q9PVM4...”

1spgB / P56251 Carbonmonoxy hemoglobin from the teleost fish leiostomus xanthurus (see paper)
P56251 Hemoglobin subunit beta from Leiostomus xanthurus
62% identity, 29% coverage

• Ligand: protoporphyrin ix containing fe (1spgB)
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...Q6WN25 Q941Q1 P10786 P18707 P21766 P56250 P68026 P68240 P84204 Q3MQ26 Q6WN26 Q946U7 P10883 P18969 P21767 P56251 P68027 P68256 P84205 Q3S3T0 Q6WN27 Q947C5 P10885 P18970 P21768 P56285 P68028 P68257 P84206 Q3TUN7 Q6WN28 Q94FG6 P10892 P18971 P21871 P56691 P68029 P68258 P84216 Q3U0A6 Q6WN29 Q94FT7 P10893 P18972 P22740 P56692...”

Q9PVM2 Hemoglobin subunit beta-A from Seriola quinqueradiata
64% identity, 28% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P68069 P82113 Q1AGS4 Q5BLF6 Q7M421 Q9PVM1 P14389 P19646 P29626 P63112 P68070 P82315 Q1AGS5 Q5GLZ6 Q7M422 Q9PVM2 P14390 P19759 P29628 P67815 P68071 P82316 Q1AGS6 Q5GLZ7 Q7T1B0 Q9PVM3 P14391 P19760 P30892 P67816 P68077 P82345 Q1AGS7 Q5I122 Q7Y079 Q9PVM4 P14392 P19789 P30893 P67817 P68078 P82990 Q1AGS8 Q5KSB7 Q7Y1Y1 Q9PVU6...”

Q6Y239 Hemoglobin subunit beta from Pagrus major
64% identity, 28% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P56691 P68029 P68258 P84216 Q3U0A6 Q6WN29 Q94FT7 P10893 P18972 P22740 P56692 P68030 P68871 P84217 Q3Y9L5 Q6Y239 Q94FT8 P11025 P18973 P22741 P60523 P68031 P68872 P84479 Q3Y9L6 Q6Y257 Q95190 P11251 P18974 P22742 P60524 P68044 P68873 P84604 Q42665 Q760P9 Q95238 P11342 P18975 P22743 P60525 P68045 P68944 P84609 Q42831 Q760Q0...”

O13164 Hemoglobin subunit beta from Decapterus maruadsi
64% identity, 28% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P02139 P06643 P08223 P0C0U6 O13163 P01941 P01973 P02004 P02038 P02076 P02109 P02140 P07034 P08224 P0C0U7 O13164 P01942 P01975 P02005 P02039 P02077 P02110 P02141 P07035 P08225 P0C0U8 10.1371/journal.pone.0009550.t003 Table 3 SwissProt/UniProt Accession Numbers for Hemoglobin dataset Part 2. P0C237 P14524 P20018 P41327 P67822 P68194 P83132 Q27940 Q6AW44...”

1outB / P02142 Trout hemoglobin i (see paper)
P02142 Hemoglobin subunit beta-1 from Oncorhynchus mykiss
60% identity, 29% coverage

• Ligand: protoporphyrin ix containing fe (1outB)
• Starvation alters the liver transcriptome of the innate immune response in Atlantic salmon (Salmo salar)
  Martin, BMC genomics 2010
  • “...AJ425729 -3.71 Cd (P02019) Hemoglobin alpha-1 subunit (Hemoglobin alpha-1 chain) (Alpha-1-globin) mus_snm_10F04_osl_tra_nrc_5p_11C EG648831 -4.16 Cd (P02142) Hemoglobin beta-1 subunit swi_rpk_74B22_osl_sgp_std_5p_11C CK896319 -6.95 Cd (Q01584) Lipocalin precursor Energy metabolism swi_rpk_74M05_osl_sgp_std_5p_11S CK895001 3.68 Cu isocitrate dehydrogenase 2 (NADP+) mitochondrial gil_oss_52N23_osl_sal_std_5p_11C CK879377 3.05 Cu (Q9N2D5) Glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12)...”
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...Accession Numbers for Hemoglobin dataset Part 1. A1A4Q3 O24520 P01943 P01976 P02006 P02040 P02078 P02111 P02142 P07036 P08256 A1A4Q7 O24521 P01944 P01977 P02007 P02042 P02080 P02112 P02143 P07402 P08257 A1YZP4 O42425 P01945 P01978 P02008 P02044 P02081 P02113 P02208 P07403 P08258 A2TDC2 O76242 P01946 P01979 P02009 P02046...”

Q7LZC1 Hemoglobin subunit beta-3 from Muraena helena
62% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P61774 P68051 P69907 P84791 Q45XH6 Q7LZB9 Q9CWS5 P11753 P18984 P23601 P61775 P68052 P80043 P84792 Q45XH7 Q7LZC1 Q9CY06 P11754 P18985 P23602 P61920 P68053 P80044 P85081 Q45XH8 Q7LZC2 Q9CY10 P11755 P18986 P23740 P61921 P68054 P80216 P85082 Q45XI4 Q7LZC3 Q9CZK5 P11756 P18987 P23741 P61947 P68055 P80270 Q03902 Q45XI5 Q7LZL6...”

3bcqB / D0VWS2 Crystal structure of oxy-hemoglobin from brycon cephalus
62% identity, 29% coverage

• Ligands: protoporphyrin ix containing fe; oxygen molecule (3bcqB)

Q3Y9L6 Hemoglobin beta chain from Nibea miichthioides
62% identity, 28% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P22740 P56692 P68030 P68871 P84217 Q3Y9L5 Q6Y239 Q94FT8 P11025 P18973 P22741 P60523 P68031 P68872 P84479 Q3Y9L6 Q6Y257 Q95190 P11251 P18974 P22742 P60524 P68044 P68873 P84604 Q42665 Q760P9 Q95238 P11342 P18975 P22743 P60525 P68045 P68944 P84609 Q42831 Q760Q0 Q95NK8 P11517 P18976 P23016 P60526 P68046 P68945 P84610 Q43306...”

Q91470 Beta-globin from Salmo salar
57% identity, 29% coverage

• Dietary Inclusion of Black Soldier Fly (Hermetia Illucens) Larvae Meal and Paste Improved Gut Health but Had Minor Effects on Skin Mucus Proteome and Immune Response in Atlantic Salmon (Salmo Salar)
  Weththasinghe, Frontiers in immunology 2021
  • “...0.003 25IM A0A1S3PWS4 NAD(P)H dehydrogenase [quinone] 1-like LOC106587985 1.61 0.004 Abundance compared to Control-2 3.7IP Q91470 Beta-globin HBB1 3.53 0.028 1 Control-1: Control diet. 12.5IM and 25IM: BSFL meal substituted 12.5% and 25% of protein content of Control-1. Control-2: Control diet with 0.88% of formic acid....”

O13163 Hemoglobin subunit beta from Silurus asotus
60% identity, 28% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P02138 P06642 P08054 P09909 O13078 P01940 P01972 P02003 P02036 P02075 P02108 P02139 P06643 P08223 P0C0U6 O13163 P01941 P01973 P02004 P02038 P02076 P02109 P02140 P07034 P08224 P0C0U7 O13164 P01942 P01975 P02005 P02039 P02077 P02110 P02141 P07035 P08225 P0C0U8 10.1371/journal.pone.0009550.t003 Table 3 SwissProt/UniProt Accession Numbers for Hemoglobin dataset...”

LOC108257036 hemoglobin subunit beta from Ictalurus punctatus
62% identity, 28% coverage

• Single-nuclei transcriptome analysis of channel catfish spleen provides insight into the immunome of an aquaculture-relevant species
  Aldersey, PloS one 2024
  • “...red blood cells with oxidative stress. Cluster 2 cells significantly increased expression of hemoglobin subunits, LOC108257036 (hemoglobin subunit beta) and LOC108257041 (hemoglobin subunit alpha). The remaining genes highly expressed by this cluster have not been characterized. Cluster 3 cells have increased expression of ank1a (ankyrin 1),...”

Q6S9E2 Hemoglobin-beta from Ictalurus punctatus
62% identity, 28% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P68019 P68232 P83612 Q29415 Q6R7N2 Q90485 Q9Y0E6 P10780 P16309 P21200 P51440 P68020 P68234 P83613 Q2KPA3 Q6S9E2 Q90486 Q9YGW1 P10781 P16417 P21201 P51441 P68021 P68235 P83614 Q2KPA4 Q6T497 Q90487 Q9YGW2 P10782 P16418 P21379 P51442 P68022 P68236 P83623 Q2MHE0 Q6WN20 Q90ZM4 P10783 P17689 P21380 P51443 P68023 P68237 P83624...”

C0H744 Hemoglobin subunit beta-1 from Salmo salar
55% identity, 29% coverage

• Properties of peptides released from salmon and carp via simulated human-like gastrointestinal digestion described applying quantitative parameters
  Borawska-Dziadkiewicz, PloS one 2021
  • “...B5X6D1, B9ENR7, B9EPT7, B5X603, B9ENY2), other salmon proteins (C0H9S7, B5X659, C1K2L7, A7KE05, C0H805, B5X746, B5X8L0, C0H744, P21848, C0HBF1, B5X4Z3, B5XDG3, B9EQI5, B5DG30, B5XBY4, B5DGI9, C0HAB6, B9EM16, Q9W6K6), carp myofibrillar proteins (P53479, P83750, Q6TKP4, Q6TKP5, Q7T2J3, Q90339, Q2HX57, Q2HX56, Q5NTZ3, Q90337, O42352, Q2HX58, Q90331, Q90332, Q90333, Q9I892,...”

P80727 Hemoglobin cathodic subunit beta from Anguilla anguilla
60% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P11758 P18989 P24292 P62363 P68057 P80726 Q0PG38 Q45XI7 Q7LZM7 Q9FUD6 P11896 P18990 P24589 P62387 P68058 P80727 Q0WSU5 Q45XI8 Q7LZM8 Q9FVL0 P13273 P18993 P24659 P62741 P68059 P80945 Q0ZA50 Q45XI9 Q7M2Y4 Q9FY42 P13274 P18994 P24660 P62742 P68060 P80946 Q10732 Q45XJ0 Q7M2Y5 Q9GJS7 P13557 P18995 P26915 P63105 P68061 P81023...”
• Structural-functional characterization of the cathodic haemoglobin of the conger eel Conger conger: molecular modelling study of an additional phosphate-binding site
  Pellegrini, The Biochemical journal 2003
  • “...under the following accession numbers: A. anguilla cathodic Hb, P80727 and P80726; and A. anguilla anodic Hb, P80946 and P80945. G. unicolor sequences were from...”
  • “...the SWISS-PROT protein knowledgebase under the accession numbers P80727 and P80726; M. helena Hb I (cathodic) sequence were from [10], and G. unicolor cathodic...”

HBBC_HOPLI / P82316 Hemoglobin cathodic subunit beta; Hemoglobin cathodic beta chain; Hb(Ca) beta chain from Hoplosternum littorale (Hassar) (see paper)
57% identity, 29% coverage

• function: Involved in oxygen transport from gills to the various peripheral tissues
  subunit: Heterotetramer of two alpha chains and two beta chains.
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P14389 P19646 P29626 P63112 P68070 P82315 Q1AGS5 Q5GLZ6 Q7M422 Q9PVM2 P14390 P19759 P29628 P67815 P68071 P82316 Q1AGS6 Q5GLZ7 Q7T1B0 Q9PVM3 P14391 P19760 P30892 P67816 P68077 P82345 Q1AGS7 Q5I122 Q7Y079 Q9PVM4 P14392 P19789 P30893 P67817 P68078 P82990 Q1AGS8 Q5KSB7 Q7Y1Y1 Q9PVU6 P14520 P19831 P33499 P67818 P68079 P83114...”

P14521 Hemoglobin subunit beta from Electrophorus electricus
57% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P82990 Q1AGS8 Q5KSB7 Q7Y1Y1 Q9PVU6 P14520 P19831 P33499 P67818 P68079 P83114 Q1AGS9 Q5MD69 Q7ZT21 Q9TS34 P14521 P19832 P41260 P67819 P68087 P83123 Q1W6G9 Q5RM02 Q803Z5 Q9TS35 P14522 P19885 P41261 P67820 P68168 P83124 Q26505 Q5XLE5 Q862A7 Q9TSN7 P14523 P19886 P41262 P67821 P68169 P83131 Q27126 Q67XG0 Q86G74 Q9TSN8 10.1371/journal.pone.0009550.t004...”

Q6ZM12 Hemoglobin, beta adult 2 from Danio rerio
55% identity, 29% coverage

• Orthosiphon stamineus Proteins Alleviate Pentylenetetrazol-Induced Seizures in Zebrafish
  Chung, Biomedicines 2020
  • “...47,074 0.00:1.00 Eno1a Q4VBK0 ATP synthase subunit beta 200 9 3 3 55,000 0.00:1.00 Atp5f1b Q6ZM12 Hemoglobin beta adult 2 200 13 3 3 16,295 0.00:1.00 Hbba2 E7F2M5 CD59 molecule (CD59 blood group) 200 26 2 2 12,914 0.00:1.00 Cd59 E9QBF0 Triosephosphate isomerase 200 20 4...”

XP_026229193 hemoglobin cathodic subunit beta-like from Anabas testudineus
55% identity, 29% coverage

• The hemoglobin Gly16β1Asp polymorphism in turbot (Scophthalmus maximus) is differentially distributed across European populations
  Andersen, Fish physiology and biochemistry 2020
  • “...Asp residue was only identified in the air breathing climbing perch ( Anabas testudineus , XP_026229193) and blunt snouted clingfish ( Gouania willdenowi , XP_028310257) and in the hypoxia tolerant catfish species Pangasianodon hypophthalmus (XP_026785154), Ictalurus punctatus (XP_017309923), and I. furcatus (AD028060). Contrasting with the higher...”

XP_026785154 hemoglobin, beta adult 2 from Pangasianodon hypophthalmus
60% identity, 29% coverage

• The hemoglobin Gly16β1Asp polymorphism in turbot (Scophthalmus maximus) is differentially distributed across European populations
  Andersen, Fish physiology and biochemistry 2020
  • “...clingfish ( Gouania willdenowi , XP_028310257) and in the hypoxia tolerant catfish species Pangasianodon hypophthalmus (XP_026785154), Ictalurus punctatus (XP_017309923), and I. furcatus (AD028060). Contrasting with the higher pH sensitivity (Bohr effect) of the cathodic turbot Hb-I(1/1) allelic variant than Hb-I(2/2) (Samuelsen et al. 1999 ), cathodic...”

XP_017309923 hemoglobin cathodic subunit beta isoform X1 from Ictalurus punctatus
57% identity, 29% coverage

• The hemoglobin Gly16β1Asp polymorphism in turbot (Scophthalmus maximus) is differentially distributed across European populations
  Andersen, Fish physiology and biochemistry 2020
  • “...willdenowi , XP_028310257) and in the hypoxia tolerant catfish species Pangasianodon hypophthalmus (XP_026785154), Ictalurus punctatus (XP_017309923), and I. furcatus (AD028060). Contrasting with the higher pH sensitivity (Bohr effect) of the cathodic turbot Hb-I(1/1) allelic variant than Hb-I(2/2) (Samuelsen et al. 1999 ), cathodic teleost globins in...”

HBBC_CONCO / P83478 Hemoglobin cathodic subunit beta; Hemoglobin cathodic beta chain from Conger conger (Conger eel) (Muraena conger) (see paper)
55% identity, 29% coverage

• function: Involved in oxygen transport from the gills to the various peripheral tissues
  subunit: Heterotetramer of two alpha chains and two beta chains.
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P20854 P45719 P68015 P68228 P83273 Q28775 Q6IBF6 Q8GV41 Q9XSN3 P10061 P15166 P20855 P45720 P68016 P68229 P83478 Q28779 Q6LDH0 Q8GV42 Q9XTL1 P10062 P15448 P21197 P45721 P68017 P68230 P83479 Q28931 Q6LDH1 Q8HY34 Q9XTM2 P10777 P15449 P21198 P45722 P68018 P68231 P83611 Q28932 Q6QDC2 Q8QG65 Q9Y0D5 P10778 P15469 P21199 P51438...”
• Structural-functional characterization of the cathodic haemoglobin of the conger eel Conger conger: molecular modelling study of an additional phosphate-binding site
  Pellegrini, The Biochemical journal 2003
  • “...protein knowledgebase under the accession numbers P83479 and P83478 respectively. c 2003 Biochemical Society 680 M. Pellegrini and others Hb [13] and Hbs from...”

P84204 Hemoglobin cathodic subunit beta from Gymnothorax unicolor
55% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P18436 P21668 P55267 P68025 P68239 P84203 Q3C1F4 Q6WN25 Q941Q1 P10786 P18707 P21766 P56250 P68026 P68240 P84204 Q3MQ26 Q6WN26 Q946U7 P10883 P18969 P21767 P56251 P68027 P68256 P84205 Q3S3T0 Q6WN27 Q947C5 P10885 P18970 P21768 P56285 P68028 P68257 P84206 Q3TUN7 Q6WN28 Q94FG6 P10892 P18971 P21871 P56691 P68029 P68258 P84216...”

Q7LZC2 Hemoglobin subunit beta-1 from Muraena helena
57% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P61775 P68052 P80043 P84792 Q45XH7 Q7LZC1 Q9CY06 P11754 P18985 P23602 P61920 P68053 P80044 P85081 Q45XH8 Q7LZC2 Q9CY10 P11755 P18986 P23740 P61921 P68054 P80216 P85082 Q45XI4 Q7LZC3 Q9CZK5 P11756 P18987 P23741 P61947 P68055 P80270 Q03902 Q45XI5 Q7LZL6 Q9D0B2 P11757 P18988 P24291 P61948 P68056 P80271 Q0PB48 Q45XI6 Q7LZM6...”

P84206 Hemoglobin anodic subunit beta from Gymnothorax unicolor
52% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P18969 P21767 P56251 P68027 P68256 P84205 Q3S3T0 Q6WN27 Q947C5 P10885 P18970 P21768 P56285 P68028 P68257 P84206 Q3TUN7 Q6WN28 Q94FG6 P10892 P18971 P21871 P56691 P68029 P68258 P84216 Q3U0A6 Q6WN29 Q94FT7 P10893 P18972 P22740 P56692 P68030 P68871 P84217 Q3Y9L5 Q6Y239 Q94FT8 P11025 P18973 P22741 P60523 P68031 P68872 P84479...”

B1Q450 Hemoglobin beta chain subunit from Mus musculus
52% identity, 29% coverage

• Carbonate Apatite and Hydroxyapatite Formulated with Minimal Ingredients to Deliver SiRNA into Breast Cancer Cells In Vitro and In Vivo
  Islam, Journal of functional biomaterials 2020
  • “...15826 7.13 Beta-globin Q61650 5690 4.65 Beta-globin A8DUM2 15780 7.13 Beta-globin D4N6U4 15880 7.13 Beta-globin B1Q450 15840 7.13 Beta-globin D0U269 15854 7.13 Beta-globin Q9CY06 15112 7.97 Globin domain-containing protein Heme, iron, binding Q9CY10 15202 8.95 Globin domain-containing protein Q8BPF4 15181 8.72 Globin domain-containing protein Q6LD55 11319...”
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P02127 P04346 P07417 P09420 B1H216 P01928 P01960 P01992 P02022 P02060 P02095 P02128 P04442 P07419 P09421 B1Q450 P01929 P01961 P01993 P02024 P02061 P02097 P02129 P04443 P07421 P09422 B2BP38 P01930 P01962 P01994 P02025 P02062 P02099 P02130 P04444 P07425 P09423 B2ZUE0 P01932 P01963 P01995 P02026 P02064 P02100 P02131 P06148...”

4esaD / K7N5M6 X-ray structure of carbonmonoxy hemoglobin of eleginops maclovinus (see paper)
50% identity, 29% coverage

• Ligand: protoporphyrin ix containing fe (4esaD)

HBB1_ELEMC / K7N5M6 Hemoglobin subunit beta-1; Beta-1-globin; Hemoglobin beta-1 chain from Eleginops maclovinus (Patagonian blennie) (Eleginus maclovinus) (see paper)
50% identity, 29% coverage

• function: Involved in oxygen transport from gills to the various peripheral tissues.
  subunit: Hb1 is a heterotetramer of two alpha-1 chains and two beta-1 chains. Hb2 is a heterotetramer of two alpha-2 chains and two beta-1 chains. HbC is a heterotetramer of two alpha-1 chains and two beta-2 chains.

A8DUP5 Beta-globin from Mus musculus
52% identity, 29% coverage

• Carbonate Apatite and Hydroxyapatite Formulated with Minimal Ingredients to Deliver SiRNA into Breast Cancer Cells In Vitro and In Vivo
  Islam, Journal of functional biomaterials 2020
  • “...7.97 Alpha globin 1 A8DUV3 15085 7.97 Alpha-globin D0U270 15840 7.13 Beta-globin Hemoglobin beta subunit A8DUP5 15894 7.09 Beta-globin A8DUK0 15840 7.13 Beta-globin A8DUP7 15826 7.13 Beta-globin Q61650 5690 4.65 Beta-globin A8DUM2 15780 7.13 Beta-globin D4N6U4 15880 7.13 Beta-globin B1Q450 15840 7.13 Beta-globin D0U269 15854 7.13...”

A8DUM2 Beta-globin from Mus musculus
52% identity, 29% coverage

• Carbonate Apatite and Hydroxyapatite Formulated with Minimal Ingredients to Deliver SiRNA into Breast Cancer Cells In Vitro and In Vivo
  Islam, Journal of functional biomaterials 2020
  • “...15894 7.09 Beta-globin A8DUK0 15840 7.13 Beta-globin A8DUP7 15826 7.13 Beta-globin Q61650 5690 4.65 Beta-globin A8DUM2 15780 7.13 Beta-globin D4N6U4 15880 7.13 Beta-globin B1Q450 15840 7.13 Beta-globin D0U269 15854 7.13 Beta-globin Q9CY06 15112 7.97 Globin domain-containing protein Heme, iron, binding Q9CY10 15202 8.95 Globin domain-containing protein...”

A8DUP7 Beta-globin from Mus musculus
52% identity, 29% coverage

• Carbonate Apatite and Hydroxyapatite Formulated with Minimal Ingredients to Deliver SiRNA into Breast Cancer Cells In Vitro and In Vivo
  Islam, Journal of functional biomaterials 2020
  • “...D0U270 15840 7.13 Beta-globin Hemoglobin beta subunit A8DUP5 15894 7.09 Beta-globin A8DUK0 15840 7.13 Beta-globin A8DUP7 15826 7.13 Beta-globin Q61650 5690 4.65 Beta-globin A8DUM2 15780 7.13 Beta-globin D4N6U4 15880 7.13 Beta-globin B1Q450 15840 7.13 Beta-globin D0U269 15854 7.13 Beta-globin Q9CY06 15112 7.97 Globin domain-containing protein Heme,...”

HBB1_MOUSE / P02088 Hemoglobin subunit beta-1; Beta-1-globin; Hemoglobin beta-1 chain; Hemoglobin beta-major chain from Mus musculus (Mouse) (see 3 papers)
A8DUK0 Beta-globin from Mus musculus
D0U270 Beta-globin from Mus musculus castaneus
52% identity, 29% coverage

• function: Involved in oxygen transport from the lung to the various peripheral tissues
  subunit: Heterotetramer of two alpha chains and two beta chains
• DCC, a potential target for controlling fear memory extinction and hippocampal LTP in male mice receiving single prolonged stress.
  Yang, Neurobiology of stress 2024
  • “...71.3 70.8 149.4 148.4 5.16E-05 2.095707 Q91X72 Hpx Hemopexin 78.2 87.2 111.3 108.4 0.029011 1.328295 P02088 Hbb-b1 Hemoglobin subunit beta-1 83.2 90.9 115.1 111.2 0.026269 1.299828 Q8C0Q2 Zhx3 Zinc fingers and homeoboxes protein 3 90.8 84.3 113.7 113.3 0.015382 1.296402 Q8CEE7 Rdh13 Retinol dehydrogenase 13 84.1...”
• Neuroprotective effects of acteoside in a glaucoma mouse model by targeting Serta domain-containing protein 4.
  Hao, International journal of ophthalmology 2024
• Changes in protein fluxes in skeletal muscle during sequential stages of muscle regeneration after acute injury in male mice.
  Bizieff, Scientific reports 2024
  • “...1 alpha subcomplex subunit 9 Q9DC69 OxPhos 9.9065.739% 8.3731.546% 5.3751.076% 125 Hemoglobin subunit beta 1 P02088 Extracellular 2.9870.566% 2.9330.685% 2.5980.668% 126 Electron transfer flavoprotein subunit alpha Q99LC5 OxPhos 8.7829.531% 9.2282.616% 4.5490.808% 127 Phosphate carrier protein Q8VEM8 Mitochondria 2.8241.441% 6.1193.707% 3.5482.193% Average % turnover per daystandard deviation...”
• Glutathione Non-Covalent Binding Sites on Hemoglobin and Major Glutathionylation Target betaCys93 Are Conservative among Both Hypoxia-Sensitive and Hypoxia-Tolerant Mammal Species
  Anashkina, International journal of molecular sciences 2023
  • “...93 locate cysteines in two of the five potentially functional sequences of Mus musculus N (P02088 and P02089) beta-hemoglobins. One of the four sequences of Nannospalax galili HR HbB (A0A8C6RII4) is the most highly divergent. It contains cysteines at positions 13, 32, 50 and 93. In...”
• Proteomic analysis reveals activation of platelet- and fibrosis-related pathways in hearts of ApoE-/- mice exposed to diesel exhaust particles.
  Jung, Scientific reports 2023
  • “...anion transport protein 2.21 0.018 Q9QYB8 ADD2 Beta-adducin 2.07 0.008 P21956 MFGE8 Lactadherin 2.00 0.023 P02088 HBB-B1 Hemoglobin subunit beta-1 1.99 0.027 Q80X19 COL14A1 Collagen alpha-1(XIV) chain 1.96 0.039 Q9Z1T2 THBS4 Thrombospondin-4 1.96 0.024 P49222 EPB42 Protein 4.2 1.94 0.009 P15327 BPGM Bisphosphoglycerate mutase 1.90 0.034...”
• Changes to Urinary Proteome in High-Fat-Diet ApoE^-/- Mice
  Hua, Biomolecules 2022
  • “...0.32 0.63 [ 131 ] P07759 P01011 Serine protease inhibitor A3K 0.26 [ 38 ] P02088 P68871 Hemoglobin subunit beta-1 0.24 P01027 P01024 Complement C3 0.20 [ 56 ] Q00898 P01009 Alpha-1-antitrypsin 1-5 0.18 [ 23 ] P11672 P80188 Neutrophil gelatinase-associated lipocalin 0.04 [ 132 ]...”
• Effects of long-term low dose saxitoxin exposure on nerve damage in mice
  Sun, Aging 2021
  • “...OX=10090 GN=Kng1 -0.352078 -0.485358 -0.371883 O09114 Prostaglandin-H2 D-isomerase OS=Mus musculus OX=10090 GN=Ptgds -0.439215 -0.340374 -0.379188 P02088 Hemoglobin subunit beta-1 OS=Mus musculus OX=10090 GN=Hbb-b -0.452371 -0.626415 -0.532594 P04919 Band 3 anion transport protein OS=Mus musculus OX=10090 GN=Slc4a1 -0.465134 -0.482751 -0.415192 P07724 Serum albumin OS=Mus musculus OX=10090 GN=Alb...”
• Proteomic profiling of the interface between the stomach wall and the pancreas in dystrophinopathy
  Dowling, European journal of translational myology 2021
  • “...mitochondrial Hspa9 7 0.000879 2 P56480 ATP synthase subunit beta, mitochondrial Atp5f1b 3 0.02928 2 P02088 Hemoglobin subunit beta-1 Hbb-b1 5 0.008807 1.9 Q8VDD5 Myosin-9 Myh9 18 0.006118 1.8 P26231 Catenin alpha-1 Ctnna1 3 0.0094 1.8 Q02819 Nucleobindin-1 Nucb1 5 0.002401 1.7 P11983 T-complex protein 1...”
• More
• Could a Non-Cellular Molecular Interactome in the Blood Circulation Influence Pathogens' Infectivity?
  Hardy, Cells 2023
  • “...delivery (e.g., cancer therapy) Acute phase: Alpha-2-macroglobulin Lipid transport: Apolipoprotein C-III, apolipoprotein E Others: Beta-globin (A8DUK0 [+2]), Beta-globin (A8DUK4), Beta-2-globin (fragment), Beta-globin OS, Alpha-globin 1 (Q91V88 [+2]), Alpha-globin A8DUV1, Ig mu chain region [ 15 ] PEGylated cationic liposomes DOTAP, DC-Chol, DOPC, DOPE, and DOPE-PEG 2000...”
• ECM Characterization Reveals a Massive Activation of Acute Phase Response during FSGS
  Bukosza, International journal of molecular sciences 2020
  • “...Q91X17 UMOD Uromodulin 8.8 Q54AH9 HBB-B2 Hemoglobin subunit beta-2 8.7 Q542I3 CRP C-reactive protein 7.6 A8DUK0 HBB-B1 Hemoglobin subunit beta-1 7.4 P01029 C4B Complement C4-B 6.2 P07759 SERPINA3 Serine protease inhibitor A3K 6.1 A0A2P9DUN6 SERPINA1 Alpha-1-antitrypsin 1 5.6 Q00623 APOA1 Apolipoprotein A-I 5.3 P11087 COL1A1 Collagen...”
• Carbonate Apatite and Hydroxyapatite Formulated with Minimal Ingredients to Deliver SiRNA into Breast Cancer Cells In Vitro and In Vivo
  Islam, Journal of functional biomaterials 2020
  • “...A8DUV3 15085 7.97 Alpha-globin D0U270 15840 7.13 Beta-globin Hemoglobin beta subunit A8DUP5 15894 7.09 Beta-globin A8DUK0 15840 7.13 Beta-globin A8DUP7 15826 7.13 Beta-globin Q61650 5690 4.65 Beta-globin A8DUM2 15780 7.13 Beta-globin D4N6U4 15880 7.13 Beta-globin B1Q450 15840 7.13 Beta-globin D0U269 15854 7.13 Beta-globin Q9CY06 15112 7.97...”
• Multifactorial comparative proteomic study of cytochrome P450 2E1 function in chronic alcohol administration.
  Wang, PloS one 2014
  • “...Uncharacterized protein Gpd1 oxidation reduction - 1.25 Q9CQB4 MCG67985 Uqcrb * oxidation reduction - 1.22 A8DUK0 Beta-globin Hbb-b1 * transport - 1.2 Q4FJX9 Superoxide dismutase Sod2 * oxidation reduction - 1.1 Q54AH9 Beta-2-globin (Fragment) Hbb * transport - 1.08 B2RXY7 Carbonyl reductase 1 Cbr1 oxidation reduction...”
• Challenging delivery of VLHL NS plasminogen activator inhibitor-1 by osmotic pumps in diabetic mouse: A case report.
  Jankun, Experimental and therapeutic medicine 2012
  • “...A2CG44 MAD homolog 3 ( Drosophila ) 0.999 1,2 A5JUZ1 Ubiqutin subunit 1 0.994 1,2 A8DUK0 Hbbt1 0.999 1,2 A8DUV3 -globin 0.999 2 B2RSN3 Tubulin, 2B 0.999 1,4,5 High B7U582 Heat shock protein 70-2 0.999 1,2,3 B7ZNJ1 Fn1 protein 0.999 1 B8JJM3 Complement factor B 0.999...”
• Carbonate Apatite and Hydroxyapatite Formulated with Minimal Ingredients to Deliver SiRNA into Breast Cancer Cells In Vitro and In Vivo
  Islam, Journal of functional biomaterials 2020
  • “...6.78 Alpha-1-globin Hemoglobin alpha subunit Q91VB8 15112 7.97 Alpha globin 1 A8DUV3 15085 7.97 Alpha-globin D0U270 15840 7.13 Beta-globin Hemoglobin beta subunit A8DUP5 15894 7.09 Beta-globin A8DUK0 15840 7.13 Beta-globin A8DUP7 15826 7.13 Beta-globin Q61650 5690 4.65 Beta-globin A8DUM2 15780 7.13 Beta-globin D4N6U4 15880 7.13 Beta-globin...”

HBB2_DISEL / C0HJT7 Hemoglobin subunit beta-2; Beta-2-globin; Hemoglobin beta-2 chain from Dissostichus eleginoides (Patagonian toothfish) (Dissostichus amissus)
55% identity, 29% coverage

• function: Involved in oxygen transport from gills to the various peripheral tissues.
  subunit: Hb2 is a heterotetramer of two alpha chains and two beta-2 chains.

A8DUQ1 Beta-globin from Mus musculus
52% identity, 29% coverage

• Melanoma-Derived Exosomes Induce PD-1 Overexpression and Tumor Progression via Mesenchymal Stem Cell Oncogenic Reprogramming
  Gyukity-Sebestyén, Frontiers in immunology 2019
  • “...subunit Q8R105 VPS37C VPS37C, ESCRT-I subunit O88384 VTI1B Vesicle transport through interaction with t-SNAREs 1B A8DUQ1 HBBT1 Beta-globin P70356 MELA Gag-pol poliprotein P70355 MELA Envelope protein Table 2 List of exosomal miRNAs identified by SOLiD 5500xl technology. Symbol Seed regio ID let-7a-3p UAUACAA mmu-let-7a-1-3p mmu-let-7b-3p mmu-let-7c-2-3p...”

NP_032246 hemoglobin, beta adult t chain from Mus musculus
A8DUK4 Beta-globin from Mus musculus
NP_001188320 hemoglobin, beta adult s chain from Mus musculus
52% identity, 29% coverage

• Quantitative proteomics analysis of the effects of ionizing radiation in wild type and p53 K317R knock-in mouse thymocytes
  Jenkins, Molecular & cellular proteomics : MCP 2008
  • “...NP_663521 NP_034692 NP_113581 NP_080858 NP_032548 NP_032246 NP_058063 NP_062414, NP_034114 NP_034022 NP_064432 NP_031960 NP_001074599 NP_033784 NP_059066...”
• Pathophysiology of Cerebellar Degeneration in Mitochondrial Disorders: Insights from the Harlequin Mouse
  Fernández, International journal of molecular sciences 2023
  • “...c oxidase subunit 5A, mitochondrial (COX5A) Cox5a 8.37 15.07 1 3 3 1 0.673 Miscellaneous A8DUK4 Beta-globin (-globin) Hbbt1 142.86 78.91 2 3 9 1 1.277 Q91VB8 Alpha globin 1 (-globin 1) Hba-a2 57.68 52.11 2 6 6 1 1.268 Q00623 Apolipoprotein A-I (APOA-1) ApoA-1 11.06...”
• Could a Non-Cellular Molecular Interactome in the Blood Circulation Influence Pathogens' Infectivity?
  Hardy, Cells 2023
  • “...therapy) Acute phase: Alpha-2-macroglobulin Lipid transport: Apolipoprotein C-III, apolipoprotein E Others: Beta-globin (A8DUK0 [+2]), Beta-globin (A8DUK4), Beta-2-globin (fragment), Beta-globin OS, Alpha-globin 1 (Q91V88 [+2]), Alpha-globin A8DUV1, Ig mu chain region [ 15 ] PEGylated cationic liposomes DOTAP, DC-Chol, DOPC, DOPE, and DOPE-PEG 2000 Potential vehicle to...”
• Multi-omics analysis reveals the pathogenesis of db/db mice diabetic kidney disease and the treatment mechanisms of multi-bioactive compounds combination from Salvia miltiorrhiza
  Xu, Frontiers in pharmacology 2022
  • “...compared to db/m mice. Salvia miltiorrhiza multi-bioactive compounds combination could callback Q9DBM2, S4R1W1, Q91Y97, P47738, A8DUK4, and A2ARV4. In summary, Salvia miltiorrhiza multi-bioactive compounds combination may ameliorate kidney injury in diabetes through regulation of TGF-/Smad and PI3K/Akt/FoxO signaling pathways. multi-bioactive compounds combination diabetic kidney disease multi-omics...”
  • “...and WGCNA analysis results of differentially expressed genes, 11 candidate differential proteins were selected, including A8DUK4 (Beta-globin), A2ARV4 (Low-density lipoprotein receptor-related protein 2), Q91Y97 (Fructose-bisphosphate aldolase B), Q91VB8 (Alpha-globin), Q9DBM2 (Peroxisomal bifunctional enzyme), P09411 (Phosphoglycerate kinase 1), P26443 (Glutamate dehydrogenase 1, mitochondrial), S4R1W1 (Glyceraldehyde-3-phosphate dehydrogenase), P47738...”
• Age-related disruption of the proteome and acetylome in mouse hearts is associated with loss of function and attenuated by elamipretide (SS-31) and nicotinamide mononucleotide (NMN) treatment.
  Whitson, GeroScience 2022
• Extensive mitochondrial proteome disturbance occurs during the early stages of acute myocardial ischemia.
  Wang, Experimental and therapeutic medicine 2022
  • “...globin 1 3.001 0.037 a Up P05064 ALDOA Fructose-bisphosphate aldolase A 3.409 0.026 a Up A8DUK4 HBB-BS -globin 3.730 0.004 b Up E9QNT8 ANK1 Ankyrin-1 3.885 0.040 a Up P01027 C3 Complement C3 4.137 0.044 a Up Q80YQ1 THBS1 Thrombospondin-1 5.096 0.036 a Up a P0.05,...”
• Proteomic Identification and Quantification of Snake Venom Biomarkers in Venom and Plasma Extracellular Vesicles
  Willard, Toxins 2021
  • “...potential biomarkers from mouse plasma after C. o. helleri envenomation. Accession No. Protein Fold Change A8DUK4 Beta-globin >100 A0A0R4J0I9 Low-density lipoprotein receptor-related protein 1 >100 P01644 Ig kappa chain VV region >100 G3UXX3 Sepiapterin reductase >100 A0A1W2P7F1 Complement component 1, s subcomponent 2 >100 B2RT14 UDP-glucuronosyltransferase...”
• The IgGFc-binding protein FCGBP is secreted with all GDPH sequences cleaved but maintained by interfragment disulfide bonds.
  Ehrencrona, The Journal of biological chemistry 2021
  • “...2.06E6 3.76E6 7 7 42,078 A0A0A6YXW Serum Beta-globin 22 5.21E5 7.52E5 1.23E8 3 3 15,748 A8DUK4 Serum The Asp-anhydrides formed upon GDPH cleavage of FCGBP could potentially react with water. Given that the structural prediction suggested that the formed C terminus is oriented internally in the...”
• Annexin A2 depletion exacerbates the intracerebral microhemorrhage induced by acute rickettsia and Ebola virus infections.
  Su, PLoS neglected tropical diseases 2020
  • “...NOD-like receptor signaling pathway, Progesterone-mediated oocyte maturation, Estrogen signaling pathway, Pathways in cancer, Prostate cancer A8DUK4 hemoglobin, beta adult s chain(Hbb-bs) 4.09 African trypanosomiasis, Malaria H2B1B histone cluster 1, H2bb(Hist1h2bb) 4.67 Alcoholism, Viral carcinogenesis, Systemic lupus erythematosus H2B1K histone cluster 1, H2bk(Hist1h2bk) 4.67 Alcoholism, Viral carcinogenesis,...”
• More
• ENU mutagenesis identifies the first mouse mutants reproducing human β-thalassemia at the genomic level.
  Brown, Blood cells, molecules & diseases 2013 (PubMed)
  • GeneRIF: ENU mutagenesis generated mouse lines with dominant beta-thalassemia mutations resembling those in the human disease: a nonsense mutation at codon 40 in exon 2 and a mutation at the polyadenylation signal of the beta-major gene.

HBB1_LIPTU / P85082 Hemoglobin subunit beta-1; Beta-1-globin; Hemoglobin beta-1 chain from Liparis tunicatus (Kelp snailfish) (see paper)
55% identity, 29% coverage

• function: Involved in oxygen transport from gills to the various peripheral tissues.
  subunit: Hb1 is a heterotetramer of two alpha-1 chains and two beta-1 chains.
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P18985 P23602 P61920 P68053 P80044 P85081 Q45XH8 Q7LZC2 Q9CY10 P11755 P18986 P23740 P61921 P68054 P80216 P85082 Q45XI4 Q7LZC3 Q9CZK5 P11756 P18987 P23741 P61947 P68055 P80270 Q03902 Q45XI5 Q7LZL6 Q9D0B2 P11757 P18988 P24291 P61948 P68056 P80271 Q0PB48 Q45XI6 Q7LZM6 Q9DF25 P11758 P18989 P24292 P62363 P68057 P80726 Q0PG38...”

6iyiB / A0A1Z0YU12 X-ray sequence and high resolution crystal structure of starry sturgeon methemoglobin (see paper)
52% identity, 29% coverage

• Ligand: protoporphyrin ix containing fe (6iyiB)

E9Q223 Hemoglobin, beta adult s chain (Fragment) from Mus musculus
52% identity, 41% coverage

• Glutathione Non-Covalent Binding Sites on Hemoglobin and Major Glutathionylation Target betaCys93 Are Conservative among Both Hypoxia-Sensitive and Hypoxia-Tolerant Mammal Species
  Anashkina, International journal of molecular sciences 2023
  • “...Supplementary Figure S2 ). 4.1.2. Beta Hemoglobins We excluded the sequences Q9TT33 Colobus guereza and E9Q223 Mus musculus , which lack significant sequence fragments from the N- and C-termini, respectively, from the sample. 4.1.3. Mu Hemoglobins We excluded the Sus scrofa sequence A0A5G2QP95 due to long...”
• The attenuation effect of potassium 2-(1-hydroxypentyl)-benzoate in a mouse model of diabetes-associated cognitive decline: The protein expression in the brain.
  Yu, CNS neuroscience & therapeutics 2022
  • “...cistrans isomerase FKBP1A P26883 29.63 4.55 8.16 11.9 1.81 0.039 3564 Hemoglobin subunit beta1 (Fragment) E9Q223 12.62 2.84 6.37 11.1 2.46 0.013 Note Variation ratio, the ratio of spot intensity of the KKA y mice+dlPHPB group to that of the same spot in the KKA y...”
• PepT1 Expression Helps Maintain Intestinal Homeostasis by Mediating the Differential Expression of miRNAs along the Crypt-Villus Axis
  Zhang, Scientific reports 2016 (no snippet)

Q61650 Beta-globin (Fragment) from Mus musculus
52% identity, 81% coverage

• Carbonate Apatite and Hydroxyapatite Formulated with Minimal Ingredients to Deliver SiRNA into Breast Cancer Cells In Vitro and In Vivo
  Islam, Journal of functional biomaterials 2020
  • “...Hemoglobin beta subunit A8DUP5 15894 7.09 Beta-globin A8DUK0 15840 7.13 Beta-globin A8DUP7 15826 7.13 Beta-globin Q61650 5690 4.65 Beta-globin A8DUM2 15780 7.13 Beta-globin D4N6U4 15880 7.13 Beta-globin B1Q450 15840 7.13 Beta-globin D0U269 15854 7.13 Beta-globin Q9CY06 15112 7.97 Globin domain-containing protein Heme, iron, binding Q9CY10 15202...”

O93351 Hemoglobin subunit beta from Trematomus hansoni
50% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P04241 P07410 P08849 A6YH87 O93349 P01954 P01986 P02016 P02053 P02089 P02122 P04242 P07411 P08850 A7UAU9 O93351 P01955 P01987 P02017 P02054 P02090 P02123 P04244 P07412 P08851 A9JSP7 O96457 P01956 P01988 P02018 P02055 P02091 P02124 P04245 P07413 P08852 A9XDF6 P01923 P01957 P01989 P02019 P02057 P02092 P02125 P04246 P07414...”

HBB_TRENE / P45720 Hemoglobin subunit beta-1/2; Beta-1/2-globin; Hemoglobin beta-1/2 chain from Trematomus newnesi (Dusky notothen) (see paper)
3d1kB / P45720 R/t intermediate quaternary structure of an antarctic fish hemoglobin in an alpha(co)-beta(pentacoordinate) state (see paper)
50% identity, 29% coverage

• function: Involved in oxygen transport from gills to the various peripheral tissues.
  subunit: Hb1 is a heterotetramer of two alpha-1 chains and two beta chains. Hb2 is a heterotetramer of two alpha-2 chains and two beta chains.
• Ligand: protoporphyrin ix containing fe (3d1kB)
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...Q9XSN2 P10060 P15165 P20854 P45719 P68015 P68228 P83273 Q28775 Q6IBF6 Q8GV41 Q9XSN3 P10061 P15166 P20855 P45720 P68016 P68229 P83478 Q28779 Q6LDH0 Q8GV42 Q9XTL1 P10062 P15448 P21197 P45721 P68017 P68230 P83479 Q28931 Q6LDH1 Q8HY34 Q9XTM2 P10777 P15449 P21198 P45722 P68018 P68231 P83611 Q28932 Q6QDC2 Q8QG65 Q9Y0D5 P10778...”

Q90ZM4 Hemoglobin beta chain from Epinephelus coioides
55% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P68235 P83614 Q2KPA4 Q6T497 Q90487 Q9YGW2 P10782 P16418 P21379 P51442 P68022 P68236 P83623 Q2MHE0 Q6WN20 Q90ZM4 P10783 P17689 P21380 P51443 P68023 P68237 P83624 Q2PAD4 Q6WN21 Q91473 P10784 P18435 P21667 P51465 P68024 P68238 P83625 Q3C1F3 Q6WN22 Q941P9 P10785 P18436 P21668 P55267 P68025 P68239 P84203 Q3C1F4 Q6WN25 Q941Q1...”

P02055 Hemoglobin subunit beta from Meles meles
52% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...O93351 P01955 P01987 P02017 P02054 P02090 P02123 P04244 P07412 P08851 A9JSP7 O96457 P01956 P01988 P02018 P02055 P02091 P02124 P04245 P07413 P08852 A9XDF6 P01923 P01957 P01989 P02019 P02057 P02092 P02125 P04246 P07414 P08853 B0BL34 P01924 P01958 P01990 P02020 P02058 P02093 P02126 P04252 P07415 P09105 B0BL35 P01926 P01959...”

Q54AH9 Beta-2-globin (Fragment) from Mus musculus
52% identity, 29% coverage

• ECM Characterization Reveals a Massive Activation of Acute Phase Response during FSGS
  Bukosza, International journal of molecular sciences 2020
  • “...FGG Fibrinogen gamma chain 15.4 Q3TGR2 FGB Fibrinogen beta chain 10.0 Q91X17 UMOD Uromodulin 8.8 Q54AH9 HBB-B2 Hemoglobin subunit beta-2 8.7 Q542I3 CRP C-reactive protein 7.6 A8DUK0 HBB-B1 Hemoglobin subunit beta-1 7.4 P01029 C4B Complement C4-B 6.2 P07759 SERPINA3 Serine protease inhibitor A3K 6.1 A0A2P9DUN6 SERPINA1...”
• Multifactorial comparative proteomic study of cytochrome P450 2E1 function in chronic alcohol administration.
  Wang, PloS one 2014
  • “...Beta-globin Hbb-b1 * transport - 1.2 Q4FJX9 Superoxide dismutase Sod2 * oxidation reduction - 1.1 Q54AH9 Beta-2-globin (Fragment) Hbb * transport - 1.08 B2RXY7 Carbonyl reductase 1 Cbr1 oxidation reduction - 1.02 Q9DCY1 Peptidyl-prolyl cis-trans isomerase Ppib * protein folding - 1.02 Q91V38 Heat shock protein...”

HBB2_MOUSE / P02089 Hemoglobin subunit beta-2; Beta-2-globin; Hemoglobin beta-2 chain; Hemoglobin beta-minor chain from Mus musculus (Mouse) (see paper)
Q549D9 Beta-globin from Mus musculus
52% identity, 29% coverage

• function: Involved in oxygen transport from the lung to the various peripheral tissues
  subunit: Heterotetramer of two alpha chains and two beta chains
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P28780 P63107 P68063 P81042 Q17155 Q53I65 Q7M3C2 Q9M3U9 P14260 P19014 P28781 P63108 P68064 P81043 Q17156 Q549D9 Q7M413 Q9M593 P14261 P19015 P29623 P63109 P68065 P82111 Q17157 Q549G1 Q7M418 Q9M630 P14387 P19016 P29624 P63110 P68068 P82112 Q17286 Q58L97 Q7M419 Q9PRL9 P14388 P19645 P29625 P63111 P68069 P82113 Q1AGS4 Q5BLF6...”
• Neuroprotective effects of acteoside in a glaucoma mouse model by targeting Serta domain-containing protein 4.
  Hao, International journal of ophthalmology 2024
• Glutathione Non-Covalent Binding Sites on Hemoglobin and Major Glutathionylation Target betaCys93 Are Conservative among Both Hypoxia-Sensitive and Hypoxia-Tolerant Mammal Species
  Anashkina, International journal of molecular sciences 2023
  • “...cysteines in two of the five potentially functional sequences of Mus musculus N (P02088 and P02089) beta-hemoglobins. One of the four sequences of Nannospalax galili HR HbB (A0A8C6RII4) is the most highly divergent. It contains cysteines at positions 13, 32, 50 and 93. In the beta-chain,...”
• Tandem mass tag-based proteomics analysis of type 2 diabetes mellitus with non-alcoholic fatty liver disease in mice treated with acupuncture
  Wang, Bioscience reports 2022
  • “...down Q9EQ21 Hepcidin Hamp 0.723 0.0372 down O54754 Aldehyde oxidase 1 Aox1 0.722 0.000117 down P02089 Hemoglobin subunit -2 Hbb-b2 0.719 0.00354 down O35678 Monoglyceride lipase Mgll 0.717 0.000537 down Q9Z211 Peroxisomal membrane protein 11A Pex11a 0.717 0.0019 down P70279 Surfeit locus protein 6 Surf6 0.716...”
• Ovariectomy Interferes with Proteomes of Brown Adipose Tissue in Rats.
  Chou, International journal of medical sciences 2022
  • “...3 Q8R5G7 ARAP3 0.44 0.51 1.60 0.65 0.0324 +3.64 0.544 2.129 0.972 Hemoglobin subunit beta-2 P02089 HBB2 32.68 6.17 43.2 3.69 0.0335 +1.32 4.754 2.213 0.981 Chondroitin sulfate proteoglycan 4 Q8VHY0 CSPG4 12.83 8.27 27.17 5.84 0.0336 +2.12 6.699 2.141 0.973 Coiled-coil domain-containing protein 80 Q8R2G6...”
• Biliary excretion of excess iron in mice requires hepatocyte iron import by Slc39a14.
  Prajapati, The Journal of biological chemistry 2021
  • “...1.95 Calm2 Calmodulin-2 P0DP27 13 3 1.84 0.98 1.89E-02 1.54E-01 1.72 Hbb-b2 Hemoglobin subunit beta-2 P02089 47 5 2.00 1.08 1.91E-02 1.54E-01 1.72 Ppt1 Palmitoyl-protein thioesterase 1 O88531 17 7 1.72 0.89 2.28E-02 1.64E-01 1.64 Acot1 Acyl-coenzyme A thioesterase 1 O55137 6 3 1.73 0.90 2.90E-02...”
• Doublecortin facilitates the elongation of the somatic Golgi apparatus into proximal dendrites.
  Li, Molecular biology of the cell 2021
  • “...RNA helicase A 17.37 44 0.39 Q501J6 Probable ATP-dependent RNA helicase DDX17 11.58 29 0.4 P02089 Hemoglobin subunit beta-2 31.26 78 0.4 Q08509 Epidermal growth factor receptor kinase substrate 8 3.47 8 0.43 Q0KL02 Triple functional domain protein 3.47 8 0.43 Q8K310 Matrin-3 33.58 78 0.43...”
• MRL/MpJ tendon matrix-derived therapeutic promotes improved healing outcomes in scar-mediated canonical tendon healing.
  Paredes, Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2021
  • “...Guanine nucleotide-binding protein subunit 2-like 1 35.1 P63017 Heat shock cognate 71 kDa protein 70.8 P02089 Hemoglobin subunit 2 15.9 Q9Z2X1 Heterogeneous nuclear ribonucleoprotein F 45.7 Q8C2Q7 Heterogeneous nuclear ribonucleoprotein H 51.2 B2RVP5 Histone H2A 13.5 P70168 Importin subunit 1 97.1 Q9D646 Keratin, type I cuticular...”
• iTRAQ-Based Quantitative Proteomic Analysis of Intestines in Murine Polymicrobial Sepsis with Hydrogen Gas Treatment.
  Jiang, Drug design, development and therapy 2020
  • “...Condition One Protein Name Protein IDs Gene Name Sepsis/Sham Sepsis+H 2 /Sepsis Hemoglobin subunit beta-2 P02089 Hbb-b2 1.5165 0.5305 Deleted in malignant brain tumors 1 protein Q60997 Dmbt1 1.679 0.675 Protein NDRG1 Q62433 Ndrg1 1.701 0.71 Fatty acid-binding protein, adipocyte P04117 Fabp4 1.3825 0.7285 Cytochrome P450...”
• More

LOC106525143 hemoglobin subunit beta-like from Austrofundulus limnaeus
50% identity, 29% coverage

• The genome of Austrofundulus limnaeus offers insights into extreme vertebrate stress tolerance and embryonic development
  Wagner, BMC genomics 2018
  • “...hemoglobin embryonic subunit alpha-like 1.01E-25 1370 Pseudo16S pseudo Mitochondrially encoded 16S rRNA pseudogene 9.28E-05 1281 LOC106525143 protein coding hemoglobin subunit beta-like 8.06E-41 1079 LOC106511047 protein coding prothymosin alpha-B-like 9.16E-48 1062 Down LOC106535866 protein coding heat shock cognate 70kDa protein 2.28E-16 14,958 LOC106517545 protein coding lipocalin-like 1.35E-25...”

D4N6U4 Beta-globin from Mus musculus castaneus
50% identity, 29% coverage

• Carbonate Apatite and Hydroxyapatite Formulated with Minimal Ingredients to Deliver SiRNA into Breast Cancer Cells In Vitro and In Vivo
  Islam, Journal of functional biomaterials 2020
  • “...15840 7.13 Beta-globin A8DUP7 15826 7.13 Beta-globin Q61650 5690 4.65 Beta-globin A8DUM2 15780 7.13 Beta-globin D4N6U4 15880 7.13 Beta-globin B1Q450 15840 7.13 Beta-globin D0U269 15854 7.13 Beta-globin Q9CY06 15112 7.97 Globin domain-containing protein Heme, iron, binding Q9CY10 15202 8.95 Globin domain-containing protein Q8BPF4 15181 8.72 Globin...”

D0U269 Beta-globin from Mus musculus castaneus
50% identity, 29% coverage

• Carbonate Apatite and Hydroxyapatite Formulated with Minimal Ingredients to Deliver SiRNA into Breast Cancer Cells In Vitro and In Vivo
  Islam, Journal of functional biomaterials 2020
  • “...5690 4.65 Beta-globin A8DUM2 15780 7.13 Beta-globin D4N6U4 15880 7.13 Beta-globin B1Q450 15840 7.13 Beta-globin D0U269 15854 7.13 Beta-globin Q9CY06 15112 7.97 Globin domain-containing protein Heme, iron, binding Q9CY10 15202 8.95 Globin domain-containing protein Q8BPF4 15181 8.72 Globin domain-containing protein Q6LD55 11319 6.57 APOAII Lipid binding...”

HBBC_TREBE / P45722 Hemoglobin subunit beta-C; Beta-C-globin; Hemoglobin beta-C chain from Trematomus bernacchii (Emerald rockcod) (Pseudotrematomus bernacchii) (see paper)
52% identity, 29% coverage

• function: Involved in oxygen transport from gills to the various peripheral tissues
  subunit: HbC is a heterotetramer of two alpha chains and two beta-C chains.
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...Q9XTL1 P10062 P15448 P21197 P45721 P68017 P68230 P83479 Q28931 Q6LDH1 Q8HY34 Q9XTM2 P10777 P15449 P21198 P45722 P68018 P68231 P83611 Q28932 Q6QDC2 Q8QG65 Q9Y0D5 P10778 P15469 P21199 P51438 P68019 P68232 P83612 Q29415 Q6R7N2 Q90485 Q9Y0E6 P10780 P16309 P21200 P51440 P68020 P68234 P83613 Q2KPA3 Q6S9E2 Q90486 Q9YGW1 P10781...”

HBB2_ANAMI / P83273 Hemoglobin subunit beta-2; Beta-2-globin; Hemoglobin beta-2 chain from Anarhichas minor (Arctic spotted wolffish) (see paper)
50% identity, 29% coverage

• function: Involved in oxygen transport from gills to the various peripheral tissues.
  subunit: Hb3 is a heterotetramer of two alpha-2 chains and two beta-2 chains
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P20247 P45718 P68014 P68227 P83272 Q28507 Q6H1U7 Q8GV40 Q9XSN2 P10060 P15165 P20854 P45719 P68015 P68228 P83273 Q28775 Q6IBF6 Q8GV41 Q9XSN3 P10061 P15166 P20855 P45720 P68016 P68229 P83478 Q28779 Q6LDH0 Q8GV42 Q9XTL1 P10062 P15448 P21197 P45721 P68017 P68230 P83479 Q28931 Q6LDH1 Q8HY34 Q9XTM2 P10777 P15449 P21198 P45722...”

HBBC_TRENE / P45721 Hemoglobin subunit beta-C; Beta-C-globin; Hemoglobin beta-C chain from Trematomus newnesi (Dusky notothen) (see paper)
2aa1B / P45721 Crystal structure of the cathodic hemoglobin isolated from the antarctic fish trematomus newnesi (see paper)
52% identity, 29% coverage

• function: Involved in oxygen transport from gills to the various peripheral tissues.
  subunit: HbC is a heterotetramer of two alpha-1 chains and two beta-C chains.
• Ligand: protoporphyrin ix containing fe (2aa1B)
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...Q9XSN3 P10061 P15166 P20855 P45720 P68016 P68229 P83478 Q28779 Q6LDH0 Q8GV42 Q9XTL1 P10062 P15448 P21197 P45721 P68017 P68230 P83479 Q28931 Q6LDH1 Q8HY34 Q9XTM2 P10777 P15449 P21198 P45722 P68018 P68231 P83611 Q28932 Q6QDC2 Q8QG65 Q9Y0D5 P10778 P15469 P21199 P51438 P68019 P68232 P83612 Q29415 Q6R7N2 Q90485 Q9Y0E6 P10780...”

HBBC_OPHSE / B3EWR8 Hemoglobin cathodic subunit beta; Hemoglobin cathodic beta chain from Ophisurus serpens (Serpent eel) (Muraena serpens) (see paper)
50% identity, 29% coverage

• function: Involved in oxygen transport from the gills to various peripheral tissues.
  subunit: Heterotetramer of two alpha and two beta chains.

P82345 Hemoglobin subunit beta-0 from Pagothenia borchgrevinki
52% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P14390 P19759 P29628 P67815 P68071 P82316 Q1AGS6 Q5GLZ7 Q7T1B0 Q9PVM3 P14391 P19760 P30892 P67816 P68077 P82345 Q1AGS7 Q5I122 Q7Y079 Q9PVM4 P14392 P19789 P30893 P67817 P68078 P82990 Q1AGS8 Q5KSB7 Q7Y1Y1 Q9PVU6 P14520 P19831 P33499 P67818 P68079 P83114 Q1AGS9 Q5MD69 Q7ZT21 Q9TS34 P14521 P19832 P41260 P67819 P68087 P83123...”

3hf4F / P02091 Crystal structure of rat methemoglobin in r2 state
50% identity, 29% coverage

• Ligand: protoporphyrin ix containing fe (3hf4F)

Q0PG38 Hemoglobin beta chain from Ochotona curzoniae
50% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P18988 P24291 P61948 P68056 P80271 Q0PB48 Q45XI6 Q7LZM6 Q9DF25 P11758 P18989 P24292 P62363 P68057 P80726 Q0PG38 Q45XI7 Q7LZM7 Q9FUD6 P11896 P18990 P24589 P62387 P68058 P80727 Q0WSU5 Q45XI8 Q7LZM8 Q9FVL0 P13273 P18993 P24659 P62741 P68059 P80945 Q0ZA50 Q45XI9 Q7M2Y4 Q9FY42 P13274 P18994 P24660 P62742 P68060 P80946 Q10732...”

NP_150237 hemoglobin subunit beta-1 from Rattus norvegicus
P02091 Hemoglobin subunit beta-1 from Rattus norvegicus
50% identity, 29% coverage

• LVV-hemorphin-7 (LVV-H7) plays a role in antinociception in a rat model of alcohol-induced pain disorders.
  Hung, Peptides 2021 (PubMed)
  • GeneRIF: LVV-hemorphin-7 (LVV-H7) plays a role in antinociception in a rat model of alcohol-induced pain disorders.
• Peripheral administration of bovine GH regulates the expression of cerebrocortical beta-globin, GABAB receptor 1, and the Lissencephaly-1 protein (LIS-1) in adult hypophysectomized rats.
  Walser, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 2011 (PubMed)
  • GeneRIF: GH regulates the expression of cerebrocortical beta-globin, GABAB receptor 1, and the Lissencephaly-1 protein (LIS-1) in adult hypophysectomized rats.
• Neurons express hemoglobin alpha- and beta-chains in rat and human brains.
  Richter, The Journal of comparative neurology 2009
  • GeneRIF: Results report that hemoglobin chains alpha2 nad beta are expressed in mammalian brain neurons and are regulated by a mitochondrial toxin.
• Molecular cloning and characterization of three adult rat beta-globin gene promoters.
  Okumura, Biochimica et biophysica acta 2004 (PubMed)
  • GeneRIF: the activities of the minimal promoters of rat beta (IIbeta, IIIbeta, and 0beta)-globin genes are proportional to the gene expression levels in vivo; erythroid-specific repressor regions immediately upstream are regulated by the same transcription factor
• Proteomic analysis of spinal dorsal horn in prior exercise protection against neuropathic pain.
  Chen, Scientific reports 2025
  • “...13 overlapping DEPs (protein accession: B1H216, B0BNN3, O55158, D4A9D6, P17475, Q63910, Q62669, P06866, A0A0G2JU, P06399, P02091, P02680 and P02770) were upregulated after CCI and downregulated in prior exercise (Fig. 2 C and Table 1 ). Table 1 shows the information of the 18 common DEPs. According...”
  • “...1 Mug1 61.406 0.04075 0.01059 0.04066 P06399 Fibrinogen alpha chain Fga 277.31 5.63E-08 0.19437 0.02408 P02091 Hemoglobin subunit beta-1 Hbb 5.6182 0.00015 0.37164 0.02759 P02680 Fibrinogen gamma chain Fgg 6.5629 0.01163 0.47771 0.04726 P02770 Albumin Alb 6.219 0.00005 0.39542 0.04185 Gene ontology (GO) annotations and kyoto...”
• Glutathione Non-Covalent Binding Sites on Hemoglobin and Major Glutathionylation Target betaCys93 Are Conservative among Both Hypoxia-Sensitive and Hypoxia-Tolerant Mammal Species
  Anashkina, International journal of molecular sciences 2023
  • “...groups of beta-hemoglobin sequences: five of the eight potential isoforms of Rattus norvegicus N (A0A0G2JTW9, P02091, A0A8I5ZXF1, A0A8L2R1Q6 and A0A8L2R6L7) and both isoforms of Cavia porcellus HR (P02095 and A0A7T7JJ63). Positions 13 and 93 locate cysteines in two of the five potentially functional sequences of Mus...”
• Physical Training vs. Perindopril Treatment on Arterial Stiffening of Spontaneously Hypertensive Rats: A Proteomic Analysis and Possible Mechanisms
  Miotto, Biomedicines 2023
  • “...only two proteins were downregulated which are in red: (P01946, Hba1) Hemoglobin subunit alpha-1/2 and (P02091, Hbb) Hemoglobin subunit beta-1 after perindopril treatment ( Figure 4 ). The comparison between SHR T and SHR C , regarding the effects of training on hypertension as shown in...”
  • “...(P04797, Gapdh) Glyceraldehyde-3-phosphate dehydrogenase; (P42930, Hspb1) Heat shock protein beta-1; (P01946, Hba1) Hemoglobin subunit alpha-1/2; (P02091, Hbb) Hemoglobin subunit beta-1; (P11517, ENSRNOP00000048546) Hemoglobin subunit beta-2; (P20760, Igg-2a) Ig gamma-2A chain C region; (P51886, Lum) Lumican; (Q64119, Myl6) Myosin light polypeptide 6; (Q64122, Myl9) Myosin regulatory light...”
• Proteomics to Metabolomics: A New Insight into the Pathogenesis of Hypertensive Nephropathy
  Eshraghi, Kidney & blood pressure research 2023
  • “...Carboxylesterase 1C 7.094 0.004 Q63041 A1m Alpha-1-macroglobulin 7.008 0.010 Q9QX79 Fetub Fetubin B 6.843 0.005 P02091 Hbb Hemoglobin subunit beta 6.730 0.044 P62329 Tmsb4x Thymosin beta-4 6.094 0.006 D3ZFC6 Itih4 Inter-alpha-trypsin inhibitor heavy chain 4 6.025 0.010 P01015 Agt Angiotensinogen 5.990 0.009 P01048 Map1 T-kininogen 1...”
  • “...6.909 0.006 A0A096MKF9 Cfb Complement factor B 6.372 0.007 Q62930 C9 Complement C9 6.034 0.006 P02091 Hbb Hemoglobin subunit beta-1 5.773 0.007 P14141 Ca3 Carbonic anhydrase 3 5.738 0.007 A0A0G2K9W7 Lrp2 Low-density lipoprotein receptor 4.32 0.009 Q68FT3 Pyroxd2 Pyridine nucleotide-disulphide 4.066 0.006 P08461 Dlat Dihydrolipoamide-S-acetyltransferase 4.054...”
• Metalloproteomic Investigation of Hg-Binding Proteins in Renal Tissue of Rats Exposed to Mercury Chloride
  de, International journal of molecular sciences 2023
  • “...) 7 Albumin 58.669 120 2 10 - Not identified - 113 2 13 P11517 P02091 Hemoglobin subunit beta-2 Hemoglobin subunit beta-1 272.2158 272.2158 138 2 14 - Not identified - 293 4 18 - Not identified - 302 5 20 - Not identified - 316...”
  • “...142.5171 142.5171 1425171 750 9 31 P02761 Major urinary protein 212.1593 349 5 35 36 P02091 P11517 Hemoglobin subunit beta-1 Hemoglobin subunit beta-2 333.9544 272.685 84 1...”
• The Influence of Lipid Microdomain Heterogeneity on Protein-Protein Interactions: Proteomic Analysis of Co-Immunoprecipitated Binding Partners of P450 1A2 and P450 3A in Rat Liver Microsomes
  Reed, Drug metabolism and disposition: the biological fate of chemicals 2023 (secret)
• Differential Post-Translational Modifications of Proteins in Bladder Ischemia.
  Choi, Biomedicines 2023
  • “...ID a Freq Protein Name Gene Name Protein ID a Freq Hemoglobin subunit beta-1 Hbb P02091 5 ATP synthase subunit beta, mitochondrial Atp5b P10719 2 14-3-3 protein zeta/delta Ywhaz P63102 1 Albumin Alb P02770 7 Non-muscle caldesmon Cald1 Q62736 2 40S ribosomal protein S4, X isoform...”
• Differential renal proteomics analysis in a novel rat model of iodinated contrast-induced acute kidney injury.
  Deng, Renal failure 2023
  • “...<0.01 P01048 T-kininogen 1 Map1 4.713 <0.01 P70668 Guanylate cyclase activator 2B Guca2b 4.68 <0.01 P02091 Hemoglobin subunit beta-1 Hbb 4.567 <0.01 Q63910 Alpha globin Hba-a3 4.492 <0.01 P04466 Myosin regulatory light chain 11 Mylpf 3.825 <0.01 G3V6W3 Kidney injury molecule 1 Havcr1/KIM1 3.72 <0.01 P02680...”
• More

Q9YGF4 Embryonic beta-type globin2 from Oncorhynchus mykiss
50% identity, 29% coverage

• Transcriptome Profiling of <i>Oncorhynchus mykiss</i> Infected with Low or Highly Pathogenic Viral Hemorrhagic Septicemia Virus (VHSV)
  Biasini, Microorganisms 2023
  • “...protein 572-like Q7Z3I7 110537993 1.14 1.34 1.11 Fluctuating- regulated hbbe2 Oncorhynchus mykiss embryonic beta-type globin2 Q9YGF4 100135792 30.69 24.95 28.27 degs2-like sphingolipiddelta(4)desaturase/C4-monooxygenase DES2-like Q6QHC5 110533418 25.74 14.96 24.86 vtg3 vitellogenin-like 991019-2 110521946 23.89 24.76 23.14 sox19b transcription factor Sox-19b-like 010111-1 Q9DDD7 110500375 23.85 14.99 22.09 s100a1...”

B2BP38 Hemoglobin beta chain from Pimephales promelas
52% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P02128 P04442 P07419 P09421 B1Q450 P01929 P01961 P01993 P02024 P02061 P02097 P02129 P04443 P07421 P09422 B2BP38 P01930 P01962 P01994 P02025 P02062 P02099 P02130 P04444 P07425 P09423 B2ZUE0 P01932 P01963 P01995 P02026 P02064 P02100 P02131 P06148 P07428 P09839 O02004 P01933 P01964 P01996 P02028 P02065 P02101 P02132 P06467...”

HBB_COTGO / P84652 Hemoglobin subunit beta; Beta-globin; Hemoglobin beta chain from Cottoperca gobio (Frogmouth) (Aphritis gobio) (see paper)
52% identity, 29% coverage

• function: Involved in oxygen transport from gills to the various peripheral tissues.
  subunit: Hb 1 is a heterotetramer of two alpha-1 and two beta chains. Hb 2 is a heterotetramer of two alpha-2 and two beta chains.
• Genomic resources for a model in adaptation and speciation research: characterization of the Poecilia mexicana transcriptome.
  Kelley, BMC genomics 2012
  • “...3 Oxygen transport [ 74 ] Erythropoietin comp50800_c0_seq1 Q5IGQ0 90 7.05E-47 1 Hemoglobin chain comp12875_c0_seq1 P84652 87 1.01E-78 1 Myoglobin comp390_c1_seq1 Q9DGJ1 91 5.58E-72 1 Aerobic/anaerobic metabolism [ 74 ] Malate dehydrogenase comp11493_c0_seq1 P11708 83 3.41E-37 1 Succinate dehydrogenase comp898_c0_seq1 Q7ZVF3 94 <1.00E-180 2 Citrate synthase...”
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P18977 P23017 P60529 P68047 P69891 P84611 Q45V69 Q760Q2 Q96FH6 P11749 P18978 P23018 P60530 P68048 P69892 P84652 Q45V70 Q78PA4 Q98905 P11750 P18981 P23019 P61772 P68049 P69905 P84653 Q45XH3 Q7JFN6 Q98TS0 P11751 P18982 P23020 P61773 P68050 P69906 P84790 Q45XH5 Q7JFR7 Q9AWA9 P11752 P18983 P23600 P61774 P68051 P69907 P84791...”

HBB2_PSEUR / P83625 Hemoglobin subunit beta-2; Beta-2-globin; Hemoglobin beta-2 chain from Pseudaphritis urvillii (Congolli) (Freshwater flathead) (see paper)
52% identity, 29% coverage

• function: Involved in oxygen transport from gills to the various peripheral tissues
  subunit: Hb2 is a heterotetramer of two alpha chains and two beta-2 chains.
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P17689 P21380 P51443 P68023 P68237 P83624 Q2PAD4 Q6WN21 Q91473 P10784 P18435 P21667 P51465 P68024 P68238 P83625 Q3C1F3 Q6WN22 Q941P9 P10785 P18436 P21668 P55267 P68025 P68239 P84203 Q3C1F4 Q6WN25 Q941Q1 P10786 P18707 P21766 P56250 P68026 P68240 P84204 Q3MQ26 Q6WN26 Q946U7 P10883 P18969 P21767 P56251 P68027 P68256 P84205...”
• Structure and function of the Gondwanian hemoglobin of Pseudaphritis urvillii, a primitive notothenioid fish of temperate latitudes
  Verde, Protein science : a publication of the Protein Society 2004
  • “...under the accession numbers P83623 (), P83624 (1), P83625 (2). Acknowledgments This study is in the framework of the Italian National Programme for Antarctic...”

HBB_CAVPO / P02095 Hemoglobin subunit beta; Beta-globin; Hemoglobin beta chain from Cavia porcellus (Guinea pig) (see paper)
3hyuB / P02095 Crystal structure of the altitude adapted hemoglobin of guinea pig. (see paper)
52% identity, 29% coverage

• function: Involved in oxygen transport from the lung to the various peripheral tissues
  subunit: Heterotetramer of two alpha chains and two beta chains.
• Ligand: protoporphyrin ix containing fe (3hyuB)
• Glutathione Non-Covalent Binding Sites on Hemoglobin and Major Glutathionylation Target betaCys93 Are Conservative among Both Hypoxia-Sensitive and Hypoxia-Tolerant Mammal Species
  Anashkina, International journal of molecular sciences 2023
  • “...norvegicus N (A0A0G2JTW9, P02091, A0A8I5ZXF1, A0A8L2R1Q6 and A0A8L2R6L7) and both isoforms of Cavia porcellus HR (P02095 and A0A7T7JJ63). Positions 13 and 93 locate cysteines in two of the five potentially functional sequences of Mus musculus N (P02088 and P02089) beta-hemoglobins. One of the four sequences of...”
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P01959 P01991 P02021 P02059 P02094 P02127 P04346 P07417 P09420 B1H216 P01928 P01960 P01992 P02022 P02060 P02095 P02128 P04442 P07419 P09421 B1Q450 P01929 P01961 P01993 P02024 P02061 P02097 P02129 P04443 P07421 P09422 B2BP38 P01930 P01962 P01994 P02025 P02062 P02099 P02130 P04444 P07425 P09423 B2ZUE0 P01932 P01963 P01995...”
• Molecular evidence for multiple origins of Insectivora and for a new order of endemic African insectivore mammals
  Stanhope, Proceedings of the National Academy of Sciences of the United States of America 1998
  • “...P14388), rat (P01946; P02091), guinea pig (P01947; P02095), tenrec (P24291; P24292), shrew (P01950; P02060), mole (P01951; P02061), and hedgehog (P01949;...”

P80946 Hemoglobin anodic subunit beta from Anguilla anguilla
52% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P13273 P18993 P24659 P62741 P68059 P80945 Q0ZA50 Q45XI9 Q7M2Y4 Q9FY42 P13274 P18994 P24660 P62742 P68060 P80946 Q10732 Q45XJ0 Q7M2Y5 Q9GJS7 P13557 P18995 P26915 P63105 P68061 P81023 Q10733 Q4F6Z2 Q7M3B6 Q9GLX4 P13558 P18996 P26916 P63106 P68062 P81024 Q17153 Q4VIX3 Q7M3B8 Q9I9I3 P14259 P19002 P28780 P63107 P68063 P81042...”
• Structural-functional characterization of the cathodic haemoglobin of the conger eel Conger conger: molecular modelling study of an additional phosphate-binding site
  Pellegrini, The Biochemical journal 2003
  • “...Hb, P80727 and P80726; and A. anguilla anodic Hb, P80946 and P80945. G. unicolor sequences were from [9], and M. helena sequences were from [10]. (a) -chain...”

P02086 Hemoglobin subunit beta from Procavia capensis habessinica
50% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P01949 P01982 P02012 P02049 P02085 P02117 P04238 P07407 P08422 A2V8C2 O88752 P01950 P01983 P02013 P02050 P02086 P02118 P04239 P07408 P08423 A4GTS5 O88754 P01951 P01984 P02014 P02051 P02087 P02120 P04240 P07409 P08535 A4GX73 O93348 P01953 P01985 P02015 P02052 P02088 P02121 P04241 P07410 P08849 A6YH87 O93349 P01954 P01986...”
• Molecular evidence for multiple origins of Insectivora and for a new order of endemic African insectivore mammals
  Stanhope, Proceedings of the National Academy of Sciences of the United States of America 1998
  • “...(P01955; P02085), manatee (P07414; P07415), hyrax (P01957; P02086), Antrozous pallidus (microbat, Evolution: Stanhope et al. P14387; P14388), rat (P01946;...”

P23018 Hemoglobin subunit beta-2 from Cygnodraco mawsoni
50% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...Q43306 Q760Q1 Q966U3 P11748 P18977 P23017 P60529 P68047 P69891 P84611 Q45V69 Q760Q2 Q96FH6 P11749 P18978 P23018 P60530 P68048 P69892 P84652 Q45V70 Q78PA4 Q98905 P11750 P18981 P23019 P61772 P68049 P69905 P84653 Q45XH3 Q7JFN6 Q98TS0 P11751 P18982 P23020 P61773 P68050 P69906 P84790 Q45XH5 Q7JFR7 Q9AWA9 P11752 P18983 P23600...”

P13274 Hemoglobin subunit beta from Chrysemys picta bellii
50% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P80727 Q0WSU5 Q45XI8 Q7LZM8 Q9FVL0 P13273 P18993 P24659 P62741 P68059 P80945 Q0ZA50 Q45XI9 Q7M2Y4 Q9FY42 P13274 P18994 P24660 P62742 P68060 P80946 Q10732 Q45XJ0 Q7M2Y5 Q9GJS7 P13557 P18995 P26915 P63105 P68061 P81023 Q10733 Q4F6Z2 Q7M3B6 Q9GLX4 P13558 P18996 P26916 P63106 P68062 P81024 Q17153 Q4VIX3 Q7M3B8 Q9I9I3 P14259...”

P16418 Hemoglobin subunit beta from Erythrolamprus miliaris
48% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...Q6S9E2 Q90486 Q9YGW1 P10781 P16417 P21201 P51441 P68021 P68235 P83614 Q2KPA4 Q6T497 Q90487 Q9YGW2 P10782 P16418 P21379 P51442 P68022 P68236 P83623 Q2MHE0 Q6WN20 Q90ZM4 P10783 P17689 P21380 P51443 P68023 P68237 P83624 Q2PAD4 Q6WN21 Q91473 P10784 P18435 P21667 P51465 P68024 P68238 P83625 Q3C1F3 Q6WN22 Q941P9 P10785 P18436...”

P11517 Hemoglobin subunit beta-2 from Rattus norvegicus
48% identity, 29% coverage

• The Microenvironment in an Experimental Model of Acute Pancreatitis Can Modify the Formation of the Protein Corona of sEVs, with Implications on Their Biological Function
  Armengol-Badia, International journal of molecular sciences 2024
  • “...rat proteins incorporated into sEVs. Uniprot Accession Protein Name Relative Abundance P01026 Complement C3 10.1 P11517 Hemoglobin subunit beta-2 8.8 P24090 Alpha-2-HS-glycoprotein 6.8 P06399 Fibrinogen alpha chain 6.3 Q99PS8 Histidine-rich glycoprotein 5.9 Q9QX79 Fetuin-B 4.5 P04276 Vitamin D-binding protein 3.2 P62138 Serine/threonine-protein phosphatase PP1-alpha catalytic subunit...”
• Seminal plasma S100A8/A9 as a potential biomarker of genital tract inflammation
  Shen, Asian journal of andrology 2024
  • “...Down 0.00171552 Glul P10715 Cytochrome c, testis-specific OS=Rattus norvegicus OX=10116 GN=Cyct 0.298 Down 1.71207E-05 Cyct P11517 Hemoglobin subunit beta-2 OS=Rattus norvegicus OX=10116 0.17 Down 0.000003175 --- P14141 Carbonic anhydrase 3 OS=Rattus norvegicus OX=10116 GN=Ca3 1.55 Up 0.000096657 Ca3 P16290 Phosphoglycerate mutase 2 OS=Rattus norvegicus OX=10116 GN=Pgam2...”
• ITRAQ Based Proteomics Reveals the Potential Mechanism of Placental Injury Induced by Prenatal Stress.
  Li, International journal of molecular sciences 2024
  • “...(H2B1) P01946 Hemoglobin subunit alpha-1/2 (Hba1) A0A0G2JSV6 Protein Hba2 (Hba2) A0A0G2JSW3 Hemoglobin subunit beta-1 (Hbb) P11517 Hemoglobin subunit beta-2 (HBB2) O88752 Epsilon 1 globin (Hbe1) Q63066 Beta-globin chain (Fragment) (Hbg1) G3V8R3 Protein Hbz (Hbz) D3ZJ08 Histone H3 (Hist2h3c2) P62804 Histone H4 (Hist2h4) Q6URK4-2 Isoform 2 of...”
• Physical Training vs. Perindopril Treatment on Arterial Stiffening of Spontaneously Hypertensive Rats: A Proteomic Analysis and Possible Mechanisms
  Miotto, Biomedicines 2023
  • “...Hspb1) Heat shock protein beta-1; (P01946, Hba1) Hemoglobin subunit alpha-1/2; (P02091, Hbb) Hemoglobin subunit beta-1; (P11517, ENSRNOP00000048546) Hemoglobin subunit beta-2; (P20760, Igg-2a) Ig gamma-2A chain C region; (P51886, Lum) Lumican; (Q64119, Myl6) Myosin light polypeptide 6; (Q64122, Myl9) Myosin regulatory light polypeptide 9; (P10111, Ppia) Peptidyl-prolyl...”
• Proteomic study on the lymphocytes from pregnant Wistar rat females treated with immunosuppressive regimen
  Wojciuk, Clinical and translational science 2023
  • “...P18291 Granzyme B 10.03 3.59 0.36 1.20E02 P06762 Heme oxygenase 1 3.63 8.55 2.36 2.03E02 P11517 Hemoglobin subunit beta2 21.91 123.23 5.62 4.46E02 F1LPR6 Immunoglobulin heavy constant mu 1.53 5.56 3.63 1.65E02 B2RYM3 Interalpha trypsin inhibitor, heavy chain 1 0.55 1.76 3.20 1.97E02 D3ZFH5 Interalphatrypsin inhibitor...”
• Metalloproteomic Investigation of Hg-Binding Proteins in Renal Tissue of Rats Exposed to Mercury Chloride
  de, International journal of molecular sciences 2023
  • “...1 ) 7 Albumin 58.669 120 2 10 - Not identified - 113 2 13 P11517 P02091 Hemoglobin subunit beta-2 Hemoglobin subunit beta-1 272.2158 272.2158 138 2 14 - Not identified - 293 4 18 - Not identified - 302 5 20 - Not identified -...”
  • “...142.5171 1425171 750 9 31 P02761 Major urinary protein 212.1593 349 5 35 36 P02091 P11517 Hemoglobin subunit beta-1 Hemoglobin subunit beta-2 333.9544 272.685 84 1...”
• Differential Post-Translational Modifications of Proteins in Bladder Ischemia.
  Choi, Biomedicines 2023
  • “...3 Phosphoglycerate mutase 1 Pgam1 P25113 1 Alpha-1-inhibitor 3 A1i3 P14046 4 Hemoglobin subunit beta-2 P11517 1 Calponin-1 Cnn1 Q08290 1 Heat shock protein beta-6 Hspb6 P97541 1 Tropomyosin beta chain Tpm2 P58775 3 Cofilin-1 Cfl1 P45592 1 Alpha-enolase Eno1 P04764 1 14-3-3 protein zeta/delta Ywhaz...”
• Proteomic analysis of rat colonic mucosa following acupuncture treatment for irritable bowel syndrome with diarrhea
  Liu, PloS one 2022
  • “...1.4 0.029 -1.5 0.0025 P35435 ATP synthase subunit gamma, mitochondrial Atp5c1 1.3 0.006 -1.4 9.90E-05 P11517 Hemoglobin subunit beta-2 N/A -4.3 0.038 2.4 0.0069 P35704 Peroxiredoxin-2 Prdx2 -1.8 0.040 1.5 0.0027 P62329 Thymosin beta-4; Hematopoietic system regulatory peptide Tmsb4x -1.7 0.044 2.0 0.023 P63036 DnaJ homolog...”
  • “...Uniprot accession Protein name Gene FC P-value T vs M P47728 Calretinin Calb2 + 0.049 P11517 Hemoglobin subunit beta-2 N/A 2.4 0.0070 P24090 Alpha-2-HS-glycoprotein Ahsg 2.1 0.043 P08932; P01048 T-kininogen 2; T-kininogen 2 heavychain; T-kinin; T-kininogen 2 light chain; T-kininogen 1; T-kininogen 1 heavy chain; T-kinin;...”
• More

P02093 Hemoglobin subunit beta from Ondatra zibethicus
50% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P01957 P01989 P02019 P02057 P02092 P02125 P04246 P07414 P08853 B0BL34 P01924 P01958 P01990 P02020 P02058 P02093 P02126 P04252 P07415 P09105 B0BL35 P01926 P01959 P01991 P02021 P02059 P02094 P02127 P04346 P07417 P09420 B1H216 P01928 P01960 P01992 P02022 P02060 P02095 P02128 P04442 P07419 P09421 B1Q450 P01929 P01961 P01993...”

P02125 Hemoglobin subunit beta from Ciconia ciconia
50% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P01988 P02018 P02055 P02091 P02124 P04245 P07413 P08852 A9XDF6 P01923 P01957 P01989 P02019 P02057 P02092 P02125 P04246 P07414 P08853 B0BL34 P01924 P01958 P01990 P02020 P02058 P02093 P02126 P04252 P07415 P09105 B0BL35 P01926 P01959 P01991 P02021 P02059 P02094 P02127 P04346 P07417 P09420 B1H216 P01928 P01960 P01992 P02022...”

HBB_TREBE / P80044 Hemoglobin subunit beta; Beta-globin; Hemoglobin beta chain from Trematomus bernacchii (Emerald rockcod) (Pseudotrematomus bernacchii) (see paper)
48% identity, 29% coverage

• function: Involved in oxygen transport from gills to the various peripheral tissues.
  subunit: Hb1 is a heterotetramer of two alpha chains and two beta chains.
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P11753 P18984 P23601 P61775 P68052 P80043 P84792 Q45XH7 Q7LZC1 Q9CY06 P11754 P18985 P23602 P61920 P68053 P80044 P85081 Q45XH8 Q7LZC2 Q9CY10 P11755 P18986 P23740 P61921 P68054 P80216 P85082 Q45XI4 Q7LZC3 Q9CZK5 P11756 P18987 P23741 P61947 P68055 P80270 Q03902 Q45XI5 Q7LZL6 Q9D0B2 P11757 P18988 P24291 P61948 P68056 P80271...”

P09907 Hemoglobin subunit beta from Rhinoceros unicornis
48% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P02104 P02135 P06637 P07432 P09906 O09232 P01937 P01968 P02000 P02032 P02072 P02105 P02136 P06638 P07433 P09907 O12985 P01938 P01969 P02001 P02033 P02073 P02106 P02137 P06639 P07803 P09908 O13077 P01939 P01971 P02002 P02035 P02074 P02107 P02138 P06642 P08054 P09909 O13078 P01940 P01972 P02003 P02036 P02075 P02108 P02139...”

HBB1_GADMO / P84610 Hemoglobin subunit beta-1; Beta-1-globin; Hemoglobin beta-1 chain from Gadus morhua (Atlantic cod) (see paper)
52% identity, 29% coverage

• function: Involved in oxygen transport from gills to the various peripheral tissues.
  subunit: Hb 1 is a heterotetramer of two alpha-1 and two beta-1 chains.
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P18975 P22743 P60525 P68045 P68944 P84609 Q42831 Q760Q0 Q95NK8 P11517 P18976 P23016 P60526 P68046 P68945 P84610 Q43306 Q760Q1 Q966U3 P11748 P18977 P23017 P60529 P68047 P69891 P84611 Q45V69 Q760Q2 Q96FH6 P11749 P18978 P23018 P60530 P68048 P69892 P84652 Q45V70 Q78PA4 Q98905 P11750 P18981 P23019 P61772 P68049 P69905 P84653...”

HBB2_GOBGI / P83614 Hemoglobin subunit beta-2; Beta-2-globin; Hemoglobin beta-2 chain from Gobionotothen gibberifrons (Humped rockcod) (Notothenia gibberifrons) (see paper)
50% identity, 29% coverage

• function: Involved in oxygen transport from gills to the various peripheral tissues
  subunit: Hb 2 is a heterotetramer of two alpha-2 and two beta-2 chains.
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P21200 P51440 P68020 P68234 P83613 Q2KPA3 Q6S9E2 Q90486 Q9YGW1 P10781 P16417 P21201 P51441 P68021 P68235 P83614 Q2KPA4 Q6T497 Q90487 Q9YGW2 P10782 P16418 P21379 P51442 P68022 P68236 P83623 Q2MHE0 Q6WN20 Q90ZM4 P10783 P17689 P21380 P51443 P68023 P68237 P83624 Q2PAD4 Q6WN21 Q91473 P10784 P18435 P21667 P51465 P68024 P68238...”

HBB1_ANAMI / P83272 Hemoglobin subunit beta-1; Beta-1-globin; Hemoglobin beta-1 chain from Anarhichas minor (Arctic spotted wolffish) (see paper)
43% identity, 29% coverage

• function: Involved in oxygen transport from gills to the various peripheral tissues.
  subunit: Hb1 is a heterotetramer of two alpha-1 chains and two beta-1 chains; Hb2 is a heterotetramer of two alpha-2 chains and two beta-1 chains
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P20246 P41332 P68013 P68226 P83271 Q28496 Q6BBK1 Q8BYM1 Q9XSK1 P10059 P15164 P20247 P45718 P68014 P68227 P83272 Q28507 Q6H1U7 Q8GV40 Q9XSN2 P10060 P15165 P20854 P45719 P68015 P68228 P83273 Q28775 Q6IBF6 Q8GV41 Q9XSN3 P10061 P15166 P20855 P45720 P68016 P68229 P83478 Q28779 Q6LDH0 Q8GV42 Q9XTL1 P10062 P15448 P21197 P45721...”

HBB1_BORSA / Q1AGS7 Hemoglobin subunit beta-1; Beta-1-globin; Hemoglobin beta-1 chain from Boreogadus saida (Polar cod) (Gadus saida) (see paper)
52% identity, 29% coverage

• function: Involved in oxygen transport from gills to the various peripheral tissues.
  subunit: Hb 1 is a heterotetramer of two alpha-1 and two beta-1 chains. Hb 2 is a heterotetramer of two alpha-2 and two beta-1 chains.
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P19759 P29628 P67815 P68071 P82316 Q1AGS6 Q5GLZ7 Q7T1B0 Q9PVM3 P14391 P19760 P30892 P67816 P68077 P82345 Q1AGS7 Q5I122 Q7Y079 Q9PVM4 P14392 P19789 P30893 P67817 P68078 P82990 Q1AGS8 Q5KSB7 Q7Y1Y1 Q9PVU6 P14520 P19831 P33499 P67818 P68079 P83114 Q1AGS9 Q5MD69 Q7ZT21 Q9TS34 P14521 P19832 P41260 P67819 P68087 P83123 Q1W6G9...”
• Haemoglobin polymorphisms affect the oxygen-binding properties in Atlantic cod populations
  Andersen, Proceedings. Biological sciences 2009
  • “...Asn at position 62; SwissProt accession nos. Q1AGS3, Q1AGS7). Based on the results herein, we suggest that the low-affinity Met variant probably transport...”

HBB1_LYCRE / P86879 Hemoglobin subunit beta-1; Beta-1-globin; Hemoglobin beta-1 chain from Lycodes reticulatus (Arctic eelpout) (see paper)
45% identity, 29% coverage

• function: Involved in oxygen transport from gills to the various peripheral tissues.
  subunit: Heterotetramer of two alpha chains and two beta chains.

P02090 Hemoglobin subunit beta from Spalax ehrenbergi
48% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P01954 P01986 P02016 P02053 P02089 P02122 P04242 P07411 P08850 A7UAU9 O93351 P01955 P01987 P02017 P02054 P02090 P02123 P04244 P07412 P08851 A9JSP7 O96457 P01956 P01988 P02018 P02055 P02091 P02124 P04245 P07413 P08852 A9XDF6 P01923 P01957 P01989 P02019 P02057 P02092 P02125 P04246 P07414 P08853 B0BL34 P01924 P01958 P01990...”

HBB2_LYCRE / P86887 Hemoglobin subunit beta-2; Beta-2-globin; Hemoglobin beta-2 chain from Lycodes reticulatus (Arctic eelpout) (see paper)
45% identity, 29% coverage

• function: Involved in oxygen transport from gills to the various peripheral tissues.
  subunit: Heterotetramer of two alpha chains and two beta chains.

P0C0U8 Hemoglobin subunit beta-1 from Drymarchon melanurus erebennus
48% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P02109 P02140 P07034 P08224 P0C0U7 O13164 P01942 P01975 P02005 P02039 P02077 P02110 P02141 P07035 P08225 P0C0U8 10.1371/journal.pone.0009550.t003 Table 3 SwissProt/UniProt Accession Numbers for Hemoglobin dataset Part 2. P0C237 P14524 P20018 P41327 P67822 P68194 P83132 Q27940 Q6AW44 Q8AXX7 Q9TSN9 P0C238 P14525 P20019 P41328 P67823 P68222 P83133 Q28220...”

Q9QUN8 Beta-2-globin (Fragment) from Mus musculus
50% identity, 29% coverage

• Global proteome profiling of dental cementum under experimentally-induced apposition
  Salmon, Journal of proteomics 2016
  • “...0.12 0.667 0.632 0.026 P02089 Hemoglobin subunit beta-2 8.67 3.54 4.12 3.33 0.017 0.006 0.024 Q9QUN8 Beta-globin 14.62 6.73 6.62 4.42 0.004 0.004 0.047 Q60770 Isoform 2 of Syntaxin-binding protein 3 1.14 0.00 0.00 0.00 0.016 0.016 0.016 Q07079 Insulin-like growth factor-binding protein 5 0.00 0.82...”

HBB1_GOBGI / P83612 Hemoglobin subunit beta-1; Beta-1-globin; Hemoglobin beta-1 chain from Gobionotothen gibberifrons (Humped rockcod) (Notothenia gibberifrons) (see paper)
45% identity, 29% coverage

• function: Involved in oxygen transport from gills to the various peripheral tissues
  subunit: Hb 1 is a heterotetramer of two alpha-1 and two beta-1 chains.
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P21198 P45722 P68018 P68231 P83611 Q28932 Q6QDC2 Q8QG65 Q9Y0D5 P10778 P15469 P21199 P51438 P68019 P68232 P83612 Q29415 Q6R7N2 Q90485 Q9Y0E6 P10780 P16309 P21200 P51440 P68020 P68234 P83613 Q2KPA3 Q6S9E2 Q90486 Q9YGW1 P10781 P16417 P21201 P51441 P68021 P68235 P83614 Q2KPA4 Q6T497 Q90487 Q9YGW2 P10782 P16418 P21379 P51442...”

P0C239 Hemoglobin subunit beta from Artedidraco orianae
43% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...Q27940 Q6AW44 Q8AXX7 Q9TSN9 P0C238 P14525 P20019 P41328 P67823 P68222 P83133 Q28220 Q6AW45 Q8AYL9 Q9TVA3 P0C239 P14526 P20243 P41329 P67824 P68223 P83134 Q28221 Q6B0K9 Q8AYM0 Q9U6L2 P0C240 P14527 P20244 P41330 P68011 P68224 P83135 Q28338 Q6BBJ0 Q8AYM1 Q9U6L6 P10057 P15162 P20245 P41331 P68012 P68225 P83270 Q28356 Q6BBJ2...”

XP_028310257 hemoglobin cathodic subunit beta-like from Gouania willdenowi
45% identity, 29% coverage

• The hemoglobin Gly16β1Asp polymorphism in turbot (Scophthalmus maximus) is differentially distributed across European populations
  Andersen, Fish physiology and biochemistry 2020
  • “...climbing perch ( Anabas testudineus , XP_026229193) and blunt snouted clingfish ( Gouania willdenowi , XP_028310257) and in the hypoxia tolerant catfish species Pangasianodon hypophthalmus (XP_026785154), Ictalurus punctatus (XP_017309923), and I. furcatus (AD028060). Contrasting with the higher pH sensitivity (Bohr effect) of the cathodic turbot Hb-I(1/1)...”

Q6WN22 Hemoglobin subunit beta from Ateles paniscus
48% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P51443 P68023 P68237 P83624 Q2PAD4 Q6WN21 Q91473 P10784 P18435 P21667 P51465 P68024 P68238 P83625 Q3C1F3 Q6WN22 Q941P9 P10785 P18436 P21668 P55267 P68025 P68239 P84203 Q3C1F4 Q6WN25 Q941Q1 P10786 P18707 P21766 P56250 P68026 P68240 P84204 Q3MQ26 Q6WN26 Q946U7 P10883 P18969 P21767 P56251 P68027 P68256 P84205 Q3S3T0 Q6WN27...”

Q6WN21 Hemoglobin subunit beta from Callimico goeldii
48% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P51442 P68022 P68236 P83623 Q2MHE0 Q6WN20 Q90ZM4 P10783 P17689 P21380 P51443 P68023 P68237 P83624 Q2PAD4 Q6WN21 Q91473 P10784 P18435 P21667 P51465 P68024 P68238 P83625 Q3C1F3 Q6WN22 Q941P9 P10785 P18436 P21668 P55267 P68025 P68239 P84203 Q3C1F4 Q6WN25 Q941Q1 P10786 P18707 P21766 P56250 P68026 P68240 P84204 Q3MQ26 Q6WN26...”

LOC101833678 hemoglobin subunit beta from Mesocricetus auratus
48% identity, 29% coverage

• HIF-1α-Dependent Metabolic Reprogramming, Oxidative Stress, and Bioenergetic Dysfunction in SARS-CoV-2-Infected Hamsters
  Jana, International journal of molecular sciences 2022
  • “...we also detected a two-fold reduction in the levels of hemoglobin subunit beta (UniProt accession LOC101833678), consistent with a retrospective study of COVID-19 patients [ 34 ], although the result did not reach statistical significance ( p -value = 0.17). We next entered the list of...”

P09909 Hemoglobin subunit beta from Phoca vitulina
48% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P02106 P02137 P06639 P07803 P09908 O13077 P01939 P01971 P02002 P02035 P02074 P02107 P02138 P06642 P08054 P09909 O13078 P01940 P01972 P02003 P02036 P02075 P02108 P02139 P06643 P08223 P0C0U6 O13163 P01941 P01973 P02004 P02038 P02076 P02109 P02140 P07034 P08224 P0C0U7 O13164 P01942 P01975 P02005 P02039 P02077 P02110 P02141...”

P10893 Hemoglobin subunit beta from Lutra lutra
48% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P68257 P84206 Q3TUN7 Q6WN28 Q94FG6 P10892 P18971 P21871 P56691 P68029 P68258 P84216 Q3U0A6 Q6WN29 Q94FT7 P10893 P18972 P22740 P56692 P68030 P68871 P84217 Q3Y9L5 Q6Y239 Q94FT8 P11025 P18973 P22741 P60523 P68031 P68872 P84479 Q3Y9L6 Q6Y257 Q95190 P11251 P18974 P22742 P60524 P68044 P68873 P84604 Q42665 Q760P9 Q95238 P11342...”

P18985 Hemoglobin subunit beta from Mico argentatus
48% identity, 29% coverage

• Protein signatures as potential surrogate biomarkers for stratification and prediction of treatment response in chronic myeloid leukemia patients.
  Alaiya, International journal of oncology 2016
  • “...4 8.10E-15 54.1252 CML-PBP-TKI-Y CML-PBP-MMR Hemoglobin chain P14391 5 4.48E-11 5.10044 CML-PBP-TKI-N CML-PBP-No-MMR Hemoglobin chain P18985 8 1.04E-09 2.8812 CML-PBP-TKI-Y CML-PBP-No-MMR Hemoglobin chain P02134 2 2.66E-09 19.544 CML-PBP-MMR CML-PBP-TKI-Y Hemoglobin chain P18984 5 4.21E-09 3.66515 CML-PBP-TKI-Y CML-PBP-MMR Hemoglobin chain P02049 5 3.19E-05 976.807 CML-PBP-TKI-Y CML-PBP-No-MMR Hemoglobin...”
• Potential biomarkers in the sera of breast cancer patients from bahawalpur, pakistan.
  Nasim, Biomarkers in cancer 2012
  • “...6.28 241 10 (3) 24 SEB5b Q9P157 ALBU_HUMAN 69321 5.92 189 5 (2) 7 SEB5c P18985 HBB_CALAR hemoglobin subunit beta 15942 6.85 135 6 (1) 21 SEB6a P01024 CO3_HUMAN complement C3 187030 6.02 625 21 (10) 9 SEB6b Q14624 ITIH4_HUMAN inter-alpha-trypsin inhibitor heavy chain H4 103293...”
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P84791 Q45XH6 Q7LZB9 Q9CWS5 P11753 P18984 P23601 P61775 P68052 P80043 P84792 Q45XH7 Q7LZC1 Q9CY06 P11754 P18985 P23602 P61920 P68053 P80044 P85081 Q45XH8 Q7LZC2 Q9CY10 P11755 P18986 P23740 P61921 P68054 P80216 P85082 Q45XI4 Q7LZC3 Q9CZK5 P11756 P18987 P23741 P61947 P68055 P80270 Q03902 Q45XI5 Q7LZL6 Q9D0B2 P11757 P18988...”

Q6WN28 Hemoglobin subunit beta from Callithrix jacchus
48% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P56251 P68027 P68256 P84205 Q3S3T0 Q6WN27 Q947C5 P10885 P18970 P21768 P56285 P68028 P68257 P84206 Q3TUN7 Q6WN28 Q94FG6 P10892 P18971 P21871 P56691 P68029 P68258 P84216 Q3U0A6 Q6WN29 Q94FT7 P10893 P18972 P22740 P56692 P68030 P68871 P84217 Q3Y9L5 Q6Y239 Q94FT8 P11025 P18973 P22741 P60523 P68031 P68872 P84479 Q3Y9L6 Q6Y257...”

C8C504 Beta-globin from Homo sapiens
48% identity, 29% coverage

• Proteomic analysis of decidua in patients with recurrent pregnancy loss (RPL) reveals mitochondrial oxidative stress dysfunction
  Yin, Clinical proteomics 2021
  • “...(RGS14), mRNA 0.476521157 0.00211812 Q9BXA2 Beta-globin (Fragment) 0.472636049 0.0112195 P69892 Hemoglobin subunit gamma-2 0.467543161 0.0169378 C8C504 Beta-globin 0.459856836 0.00578593 K7EP20 Dedicator of cytokinesis protein 6 (Fragment) 0.459262528 0.0211759 Q4TZM4 Hemoglobin beta chain (Fragment) 0.453442055 0.00422012 Q6EVJ6 Peptidyl arginine deiminase type IV (Fragment) 0.449186304 0.00218377 X6R5I7 Regulator...”
• Proteomics changes after negative pressure wound therapy in diabetic foot ulcers
  Jia, Molecular medicine reports 2021
  • “...leukemia virus 1 infection Q59GX2, Q9Y277, P27824 N/A, VDAC3, CANX 0.0192 ko05143 African trypanosomiasis A5PL32, C8C504 APOL1, HBB 0.0193 ko04919 Thyroid hormone signaling pathway Q59GX2, P54709 N/A, ATP1B3 0.0297 ko04918 Thyroid hormone synthesis P54709, P27824 ATP1B3, CANX 0.0377 ko04971 Gastric acid secretion V9HW21, P54709 HEL-76, ATP1B3...”
• Proteome Profile of Endogenous Retrotransposon-Associated Complexes in Human Embryonic Stem Cells
  Vuong, Proteomics 2019
  • “...OX=9606 GN=GIGYF1 PE=1 SV=2 Peak Found High High Not Found High Not Found HBB * C8C504 Beta-globin OS=Homo sapiens OX=9606 GN=HBB PE=3 SV=1 High Peak Found Not Found Peak Found Not Found Not Found EIF4ENIF1 * A0A024R1K0 Eukaryotic translation initiation factor 4E nuclear import factor 1,...”
• Quantitative Analysis of Ubiquitinated Proteins in Human Pituitary and Pituitary Adenoma Tissues
  Qian, Frontiers in endocrinology 2019
  • “...1.44 2.44E-01 QVDQLTNDK*AR 11 168 1 1.99E+06 2.97E+06 1.49 2.74E-01 K*LLEGEESR 9 393 1 5.54E+06 C8C504 HBB Beta-globin GTFATLSELHCDK*LHVDPENFR 22 96 1 2.04E+07 8.43E+07 4.14 5.79E-03 Q96T46 HBA2 Hemoglobin alpha 2 TYFPHFDLSHGSAQVK* 16 33 1 1.94E+06 2.03E+08 104.44 6.08E-03 Q9H582 ZNF644 Zinc finger protein 644 RSFLQQDVNK*...”
• Revealing the Amylase Interactome in Whole Saliva Using Proteomic Approaches.
  Crosara, BioMed research international 2018
  • “...region x x x 37.66 6.51 P23280 Carbonic anhydrase VI x x x 33.57 6.41 C8C504 beta-Globin x x x 15.87 7.98 A7Y9J9 Mucin 5AC, oligomeric mucus/gel-forming x x x 645.90 6.27 P01834 Ig kappa chain C region x x x 11.60 5.87 H6VRF8 Keratin 1...”
  • “...Glyceraldehyde-3-phosphate dehydrogenase (fragment) J3QLC9 Haptoglobin (fragment) B7Z565 cDNA FLJ54739, highly similar to alpha-actinin-1 C0JYZ2 Titin C8C504 beta-Globin H6VRF8 Keratin 1 P13645 Keratin, type I cytoskeletal 10 B1APF8 cAMP-dependent protein kinase catalytic subunit beta (fragment) F6KPG5 Albumin (fragment) E9PKG6 Nucleobindin-2 Q9Y6V0 Protein piccolo P10599 Thioredoxin O95661 GTP-binding...”
• Enhancement of red blood cell transfusion compatibility using CRISPR-mediated erythroblast gene editing.
  Hawksworth, EMBO molecular medicine 2018
  • “...Q59GX2 Solute carrier family 2 (Facilitated glucose transporter) Glut1 SLC2A1 13 9 86 9 1.14 C8C504 Betaglobin HBB 94 21 2,705 1 0.93 P00915 Carbonic anhydrase 1 CA1 72 16 370 2 1.27 H7BY55 Complement decayaccelerating factor CD55 9 6 12 6 1.55 E9PR17 CD59 glycoprotein...”
• Preparation and evaluation of human choroid extracellular matrix scaffolds for the study of cell replacement strategies.
  Chirco, Acta biomaterialia 2017
  • “...9 15 A0A024R972 Laminin, gamma 1 (Formerly LAMB2), isoform CRA a 44.89 8.96 10 15 C8C504 Beta-globin 40.86 21.77 3 14 A0A024RAB6 Heparan sulfate proteoglycan 2 (Perlecan), isoform CRA b 37.48 4.39 13 14 P01024 Complement C3 39.28 5.35 6 13 V9HW34 Epididymis luminal protein 213...”
• Salivary Cytoprotective Proteins in Inflammation and Resolution during Experimental Gingivitis--A Pilot Study
  Aboodi, Frontiers in cellular and infection microbiology 2015
  • “...1.20 0.000 B7ZMD7 Amylase, alpha 1A 0.79 0.001 C3PTT6 Pancreatic adenocarcinoma unregulated factor 2.25 0.012 C8C504 Beta-globin 1.77 0.018 C9J185 Eukaryotic translation initiation factor 2-alpha kinase 3 (Fragment) 1.64 0.006 C9JAJ5 Putative uncharacterized protein LOC349136 2.18 0.036 C9JC68 Fetuin-B (Fragment) 1.09 0.009 D3DPB9 Nitric oxide synthase...”

XP_002822173 hemoglobin subunit beta from Pongo abelii
48% identity, 29% coverage

• Analysis of the beta-globin gene in DNA of suspected thalassemic great apes.
  Vuch, Genetics and molecular research : GMR 2013 (PubMed)
  • GeneRIF: Pan troglodytes and Pongo pygmaeus were screened for mutations in the beta-globin gene (exons 1, 2, and 3) for suspected thalassemia.

P02026 Hemoglobin subunit beta from Macaca mulatta
48% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...B2BP38 P01930 P01962 P01994 P02025 P02062 P02099 P02130 P04444 P07425 P09423 B2ZUE0 P01932 P01963 P01995 P02026 P02064 P02100 P02131 P06148 P07428 P09839 O02004 P01933 P01964 P01996 P02028 P02065 P02101 P02132 P06467 P07429 P09840 O02480 P01934 P01965 P01997 P02029 P02066 P02102 P02133 P06635 P07430 P09904 O04985 P01935...”

P67822 Hemoglobin subunit beta from Cebus capucinus
48% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...10.1371/journal.pone.0009550.t003 Table 3 SwissProt/UniProt Accession Numbers for Hemoglobin dataset Part 2. P0C237 P14524 P20018 P41327 P67822 P68194 P83132 Q27940 Q6AW44 Q8AXX7 Q9TSN9 P0C238 P14525 P20019 P41328 P67823 P68222 P83133 Q28220 Q6AW45 Q8AYL9 Q9TVA3 P0C239 P14526 P20243 P41329 P67824 P68223 P83134 Q28221 Q6B0K9 Q8AYM0 Q9U6L2 P0C240 P14527...”

P02025 Hemoglobin subunit beta from Hylobates lar
48% identity, 29% coverage

• FFP: joint Fast Fourier transform and fractal dimension in amino acid property-aware phylogenetic analysis.
  Li, BMC bioinformatics 2022
  • “...YP_003024037 174 Human AAA16334 147 Gorilla NP_008223 174 Gorilla P02024 147 C.Chimp NP_008197 174 Gibbon P02025 146 Wallaroo NP_007405 167 G.Panda P18983 147 Harbor Seal(H.Seal) NP_006939 175 Goose P02117 146 Gray Seal(G.Seal) NP_007080 175 Swan P68945 146 Rat AP_004903 172 Goat AAA30913 145 Mouse NP_904339 172...”
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...B1Q450 P01929 P01961 P01993 P02024 P02061 P02097 P02129 P04443 P07421 P09422 B2BP38 P01930 P01962 P01994 P02025 P02062 P02099 P02130 P04444 P07425 P09423 B2ZUE0 P01932 P01963 P01995 P02026 P02064 P02100 P02131 P06148 P07428 P09839 O02004 P01933 P01964 P01996 P02028 P02065 P02101 P02132 P06467 P07429 P09840 O02480 P01934...”

P67821 Hemoglobin subunit beta from Sapajus apella
48% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...Q803Z5 Q9TS35 P14522 P19885 P41261 P67820 P68168 P83124 Q26505 Q5XLE5 Q862A7 Q9TSN7 P14523 P19886 P41262 P67821 P68169 P83131 Q27126 Q67XG0 Q86G74 Q9TSN8 10.1371/journal.pone.0009550.t004 Table 4 SwissProt/UniProt Accession Numbers for Myoglobin dataset. O77003 P02159 P02174 P02190 P02205 P14393 P51535 P68086 Q01966 Q701N9 Q9DEP1 P02144 P02160 P02177 P02191...”

P02024 Hemoglobin subunit beta from Gorilla gorilla gorilla
48% identity, 29% coverage

• FFP: joint Fast Fourier transform and fractal dimension in amino acid property-aware phylogenetic analysis
  Li, BMC bioinformatics 2022
  • “...Length 1. ND6Set 2. 10-BetaSet Human YP_003024037 174 Human AAA16334 147 Gorilla NP_008223 174 Gorilla P02024 147 C.Chimp NP_008197 174 Gibbon P02025 146 Wallaroo NP_007405 167 G.Panda P18983 147 Harbor Seal(H.Seal) NP_006939 175 Goose P02117 146 Gray Seal(G.Seal) NP_007080 175 Swan P68945 146 Rat AP_004903 172...”
  • “...145 3. 11-BetaSet 4. 17-BetaSet Human AAA16334 147 Human ALU64020 147 Lemur AAA36822 147 Gorilla P02024 147 Mouse ADD52696 147 Chimpanzee (Chimp) P68873 147 Goat AAA30913 145 Cattle CAA25111 145 Rabbit CAA24251 147 Banteng BAJ05126 145 Chimpanzee P68873 147 Goat AAA30913 145 Gorilla P02024 147 Sheep...”
• Protein Sequence Comparison and DNA-binding Protein Identification with Generalized PseAAC and Graphical Representation
  Li, Combinatorial chemistry & high throughput screening 2018
  • “...The dataset called BetaSet is composed of -globin protein of 17 species: Human (ALU64020), Gorilla (P02024), Chimpanzee (P68873), Cattle (CAA25111), Banteng (BAJ05126), Goat (AAA30913), Sheep (ABC86525), European hare (CAA68429), Rabbit (CAA24251), House mouse (ADD52660), Western wild mouse (ACY03394), Spiny mouse (ACY03377), Norway rat (CAA29887), Opossum (AAA30976),...”
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...B1H216 P01928 P01960 P01992 P02022 P02060 P02095 P02128 P04442 P07419 P09421 B1Q450 P01929 P01961 P01993 P02024 P02061 P02097 P02129 P04443 P07421 P09422 B2BP38 P01930 P01962 P01994 P02025 P02062 P02099 P02130 P04444 P07425 P09423 B2ZUE0 P01932 P01963 P01995 P02026 P02064 P02100 P02131 P06148 P07428 P09839 O02004 P01933...”

HBB_HUMAN / P68871 Hemoglobin subunit beta; Beta-globin; Hemoglobin beta chain from Homo sapiens (Human) (see 26 papers)
1dxtB / P68871 High-resolution x-ray study of deoxy recombinant human hemoglobins synthesized from beta-globins having mutated amino termini (see paper)
P68873 Hemoglobin subunit beta from Pan troglodytes
D9YZU5 Beta-globin from Homo sapiens
NP_000509 hemoglobin subunit beta from Homo sapiens
P68872 Hemoglobin subunit beta from Pan paniscus
XP_508242 hemoglobin subunit beta from Pan troglodytes
48% identity, 29% coverage

• function: Involved in oxygen transport from the lung to the various peripheral tissues.
  function: LVV-hemorphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure
  function: [Spinorphin]: Functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation
  subunit: Heterotetramer of two alpha chains and two beta chains in adult hemoglobin A (HbA). Heterotetramer of two zeta chains and two beta chains in hemoglobin Portland-2, detected in fetuses and neonates with homozygous alpha-thalassemia.
• Ligand: protoporphyrin ix containing fe (1dxtB)
• FFP: joint Fast Fourier transform and fractal dimension in amino acid property-aware phylogenetic analysis.
  Li, BMC bioinformatics 2022
  • “...147 Human ALU64020 147 Lemur AAA36822 147 Gorilla P02024 147 Mouse ADD52696 147 Chimpanzee (Chimp) P68873 147 Goat AAA30913 145 Cattle CAA25111 145 Rabbit CAA24251 147 Banteng BAJ05126 145 Chimpanzee P68873 147 Goat AAA30913 145 Gorilla P02024 147 Sheep ABC86525 145 Rat CAA33250 147 European hare...”
• A Placenta Derived C-Terminal Fragment of β-Hemoglobin With Combined Antibacterial and Antiviral Activity
  Groß, Frontiers in microbiology 2020
  • “...P02088 ; Sus scrofa (Pig) P02067 ; Oryctolagus cuniculus (Rabbit) P02057 ; Pan troglodytes (Chimpanzee) P68873 ; Bos taurus (Bovine) P02070 ; Mesocricetus auratus (Golden hamster) P02094 ; Ovis aries (Sheep) P02075 ; Macaca fascicularis (Cynomolgus monkey) P68223 ; Panthera pardus orientalis (Amur leopard) P04244 ;...”
• Protein Sequence Comparison and DNA-binding Protein Identification with Generalized PseAAC and Graphical Representation.
  Li, Combinatorial chemistry & high throughput screening 2018
  • “...called BetaSet is composed of -globin protein of 17 species: Human (ALU64020), Gorilla (P02024), Chimpanzee (P68873), Cattle (CAA25111), Banteng (BAJ05126), Goat (AAA30913), Sheep (ABC86525), European hare (CAA68429), Rabbit (CAA24251), House mouse (ADD52660), Western wild mouse (ACY03394), Spiny mouse (ACY03377), Norway rat (CAA29887), Opossum (AAA30976), Guttata (ACH46399),...”
• Integrative Analysis of CRISPR/Cas9 Target Sites in the Human HBB Gene
  Luo, BioMed research international 2015
  • “...are P02008, P02042, P02100, P02144, P09105, P68871, P69891, P69892, P69905, P01935, P06347, P61772, P61920, P61921, P68873, P69907, Q6LDH1, P01994, P02001, P02007, P02112, P02127, P02128, P02197, P01987, P02003, P04243, P14260, and P14261. ClustalX 1.83 and Mega 3.0 were used to do complete alignment and construct the cladogram....”
• Protein expression profiling in the spectrum of renal cell carcinomas.
  Valera, Journal of Cancer 2010
  • “...7.1 22,327 / 6.4 1.340e+04 8 (16) 37% CC3 Clear Cell RCC Beta globin (HBB) P68873 10.9 15,999 / 6.7 4.982e+06 10 (20) 76% CC4 Clear Cell RCC Peroxiredoxin 2 (PRX-2) P32119 2.1 21,892 / 5.6 3.237e+04 9 (18) 36% CC5 Clear Cell RCC Apolipoprotein A1...”
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P11025 P18973 P22741 P60523 P68031 P68872 P84479 Q3Y9L6 Q6Y257 Q95190 P11251 P18974 P22742 P60524 P68044 P68873 P84604 Q42665 Q760P9 Q95238 P11342 P18975 P22743 P60525 P68045 P68944 P84609 Q42831 Q760Q0 Q95NK8 P11517 P18976 P23016 P60526 P68046 P68945 P84610 Q43306 Q760Q1 Q966U3 P11748 P18977 P23017 P60529 P68047 P69891...”
• A study of the proteomic expression in patients with complicated parapneumonic pleural effusion
  Wu, Archives of medical science : AMS 2023
  • “...Table II Proteins with upregulated expressions Protein sequence Description Protein existence FC value P -value D9YZU5 Beta-globin 3 138.97 < 0.01 P06733 Alpha-enolase 1 102.13 < 0.01 P04406 Glyceraldehyde-3-phosphate dehydrogenase 1 102.13 < 0.01 P29401 Transketolase 1 91.19 < 0.01 P00558 Phosphoglycerate kinase 1 1 80.84...”
• Ubiquitination-mediated molecular pathway alterations in human lung squamous cell carcinomas identified by quantitative ubiquitinomics.
  Zhan, Frontiers in endocrinology 2022
  • “...extinguisher 1), isoform CRA_a VSILESLDK*WER 261 0.086 0.43 B2R6J2 EZR Ezrin FGDYNK*EVHK 139 0.151 0.33 D9YZU5 HBD Delta globin K*VLGAFSDGLAHLDNLK 67 0.032 1.42 VHLTPEEK*SAVTALWGK 9 0.052 FFESFGDLSTPDAVMGNPKVK* 62 0.056 GTFATLSELHCDK*LHVDPENFR 96 0.096 VVAGVANALAHK*YH 145 0.165 VLGAFSDGLAHLDNLK*GTFATLSELHCDK 83 T-/N+ FFESFGDLSTPDAVMGNPK*VK 60 T-/N+ G3V1N2 HBA2 HCG1745306, isoform CRA_a...”
• Identification of novel biomarkers and therapeutic target candidates for stasis-heat symptom pattern of acute intracerebral hemorrhage by quantitative plasma proteomics.
  Lexin, Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2022
• Multiple biomarkers of sepsis identified by novel time-lapse proteomics of patient serum
  Hayashi, PloS one 2019
  • “...2 SV 1 25552 4 P02057 Hemoglobin beta 1 and beta 2 chains 393 5 D9YZU5 Hemoglobin beta OS Homo sapiens GN HBB PE 3 SV 1 7112 6 P68871 Hemoglobin subunit beta OS Homo sapiens GN HBB PE 1 SV 2 6679 7 P01944 Hemoglobin...”
• Changes in the Urinary Proteome in a Patient-Derived Xenograft (PDX) Nude Mouse Model of Colorectal Tumor
  Liu, Scientific reports 2019
  • “...Napsin-A 69 (4/4) 1 not found A1A508 PRSS3 protein (PRSS3) 44 (1/4) 1 not found D9YZU5 Beta-globin (HBB) 33 (1/4) 6 73,156.39 P99999 Cytochrome c (CYCS) *, 26 (3/4) 4 235.11 A8K7G6 highly similar to Homo sapiens Regenerating islet-derived 1 alpha 22 (1/4) 3 not found...”
• Quantitative Analysis of Ubiquitinated Proteins in Human Pituitary and Pituitary Adenoma Tissues
  Qian, Frontiers in endocrinology 2019
  • “...from ubiquitinated peptide 67 K * VLGAFSDGLAHLDNLK 83 of hemoglobin subunit beta (P68871) or beta-globin (D9YZU5) ( Figure 1C ), which localized the ubiquitination site at K residue in the peptide N-terminal, with a high-quality MS/MS spectrum, excellent S/N ratio, and extensive product-ion b-ion and y-ion...”
  • “...0.876 2.01E+07 ADALQAGASQFETSAAKLK* 19 85 0.539 4.61E+07 DQK*LSELDDR 10 59 1 6.10E+06 5.24E+07 8.60 2.47E-03 D9YZU5 HBB Beta-globin FFESFGDLSTPDAVMGNPK*VK* 21 60;62 0.5; 0.5 2.48E+06 2.02E+07 8.14 1.14E-03 K*VLGAFSDGLAHLDNLK 17 67 1 1.79E+06 1.02E+07 5.69 4.65E-02 P62979 RPS27A Ubiquitin-40S ribosomal protein S27a IQDK*EGIPPDQQR 13 33 1 3.34E+06...”
• Proteomic analysis reveals dysregulated cell signaling in ejaculated spermatozoa from infertile men.
  Samanta, Asian journal of andrology 2019
  • “...16.7 0.0 0.0 Galectin-3-binding protein precursor Q08380 65 24.7 12.7 11.7 5.0 Hemoglobin subunit beta D9YZU5 16 24.7 13.0 8.3 7.3 40S ribosomal protein SA P08865 33 24.0 2.7 0.0 0.0 Poly(rC)-binding protein 1 Q15365 37 24.0 3.7 0.0 0.0 Serine/threonine-protein phosphatase 2A catalytic subunit beta...”
• Collagen type V a2 (COL5A2) is decreased in steroid-induced necrosis of the femoral head
  Yang, American journal of translational research 2018 (secret)
• More
• Sickle cell allele HBB-rs334(T) is associated with decreased risk of childhood Burkitt lymphoma in East Africa.
  Hong, American journal of hematology 2024
  • GeneRIF: Sickle cell allele HBB-rs334(T) is associated with decreased risk of childhood Burkitt lymphoma in East Africa.
• β0-Thalassemia Caused by a Novel Nonsense Mutation [HBB:c.199A > T].
  Waye, Hemoglobin 2024 (PubMed)
  • GeneRIF: beta[0]-Thalassemia Caused by a Novel Nonsense Mutation [HBB:c.199A > T].
• Post-GWAS Validation of Target Genes Associated with HbF and HbA2 Levels.
  Caria, Cells 2024
  • GeneRIF: Post-GWAS Validation of Target Genes Associated with HbF and HbA2 Levels.
• Molecular characterization of a novel homozygous deletion in β-globin cluster causing (δβ)0-Thalassemia among Tunisian family.
  Kalai, Annals of clinical biochemistry 2023 (PubMed)
  • GeneRIF: Molecular characterization of a novel homozygous deletion in beta-globin cluster causing (deltabeta)[0]-Thalassemia among Tunisian family.
• β-thalassemia intermedia mimicking β-thalassemia trait: The importance of family studies and HBB genotyping in phenotypically ambiguous cases.
  Singh, International journal of laboratory hematology 2023 (PubMed)
  • GeneRIF: beta-thalassemia intermedia mimicking beta-thalassemia trait: The importance of family studies and HBB genotyping in phenotypically ambiguous cases.
• Fist Detection of Hb Suqian[β42(CD1) Phe→Leu, HBB:c.129T > A] in Han Chinese.
  Wang, Hemoglobin 2023 (PubMed)
  • GeneRIF: Fist Detection of Hb Suqian[beta42(CD1) Phe-->Leu, HBB:c.129T > A] in Han Chinese.
• Molecular Basis and Hematologic Phenotype of Hemoglobin H Disease Combined with Two Rare β-Globin Mutations.
  Qiu, Hemoglobin 2023 (PubMed)
  • GeneRIF: Molecular Basis and Hematologic Phenotype of Hemoglobin H Disease Combined with Two Rare beta-Globin Mutations.
• Clinical, Biochemical, and Hematological Presentation of a ß (+) Thalassemia due to the Poly A (T- > C) Mutation (HBB c.*110T > C (rs33978907)) Discovered in a Senegalese Family.
  Tall, The journal of applied laboratory medicine 2023 (PubMed)
  • GeneRIF: Clinical, Biochemical, and Hematological Presentation of a ss (+) Thalassemia due to the Poly A (T- > C) Mutation (HBB c.*110T > C (rs33978907)) Discovered in a Senegalese Family.
• More
• Identification of plasma protein biomarkers for endometriosis and the development of statistical models for disease diagnosis.
  Schoeman, Human reproduction (Oxford, England) 2025
  • “...Association direction (endometriosis) Vitamin K-dependent protein S P07225 <0.001 Decrease 1 Negative Hemoglobin subunit beta P68871 <0.001 Increase 1 Positive Serum paraoxonase/arylesterase 1 P27169 <0.001 Increase 1 Positive Afamin P43652 <0.05 Decrease 2/3 Negative Coagulation factor XII P00748 <0.05 Decrease 2/3 Negative Complement component C9 P02748...”
• Ocular inoculation of toad venom: toxic cataract and proteomic profiling
  Lyu, Frontiers in medicine 2024
  • “...330.7835694 Up A0A1S5UZ39 Hemoglobin subunit alpha HBA2 28.93313364 Up A0N071 Delta globin HBD 19.66367327 Up P68871 Hemoglobin subunit beta HBB 15.63303839 Up P55084 Trifunctional enzyme subunit beta, mitochondrial HADHB 15.40451727 Up A0A5E4 Uncharacterized protein 12.82069667 Up B4E1B2 Beta-1 metal-binding globulin 10.12237847 Up Q9Y4P8 WD repeat domain...”
• Comparison of Peptidomes Extracted from Healthy Tissue and Tumor Tissue of the Parotid Glands and Saliva Samples
  Puchalski, International journal of molecular sciences 2024
  • “...3 P04406 Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) GAPDH 4 P04792 Heat shock protein beta-1 HSPB1 2 P69905, P68871 Hemoglobin HBA1/HBA2, HBB 5 P16402, P10412, P16401, P20671 Histones H1-3, H1-4, H1-5, H2AC7 9 P01857 Immunoglobulin heavy constant gamma 1 IGHG1 1 P04264, P13647 Keratin KRT1, KRT5 4 Q09666 Neuroblast...”
• A Pilot Study on the Proteomics Profile of Serum Exosome-Enriched Extracellular Vesicles from Normal versus Individuals with Obesity-Related Insulin Resistance
  Saraswathi, Biomedicines 2024
  • “...3.49751 23.4074 21.6011 P02751 FN1 0.00461717 2.20996 26.129 24.985 P69905 HBA2 0.00166529 2.87522 29.2208 27.6971 P68871 HBB 0.00415203 3.23454 30.1874 28.4938 A0A0C4DH39 IGHV1-58 8.15 10 5 4.95533 20.0733 17.7643 A0A0B4J2H0 IGHV1-69D 3.37 10 5 2.08215 21.1561 20.098 P0DP01 IGHV1-8 0.00231204 3.85637 19.9576 18.0103 A0A0C4DH32 IGHV3-20 0.000622795...”
• A multi-omics study to monitor senescence-associated secretory phenotypes of Alzheimer's disease
  Yang, Annals of clinical and translational neurology 2024
  • “...P05452 Tetranectin CLEC3B 0.51 0.163347401 Secreted 24 O43592 ExportinT XPOT 0.46 0.09761194 Nucleus, Cytoplasm 25 P68871 Hemoglobin subunit beta HBB 0.444 0.080222037 Blood microparticle 26 Q66K66 Transmembrane protein 198 TMEM198 0.421 0.05588057 Membrane 27 P69905 Hemoglobin subunit alpha HBA1; HBA2 0.365 0.018902331 Blood microparticle 28 Q9Y623...”
• Proteomic profile of extracellular vesicles from plasma and CSF of multiple sclerosis patients reveals disease activity-associated EAAT2
  D'Ambrosio, Journal of neuroinflammation 2024
  • “...GNAO1 Guanine nucleotide-binding protein G(o) subunit 22 P08238 HSP90AB1 Heat shock protein HSP 90- 23 P68871 HBB Hemoglobin subunit 24 P05546 SERPIND1 Heparin cofactor 2 25 P19367 HK1 Hexokinase-1 26 Q14764 MVP Major vault protein 27 Q02978 SLC25A11 Mitochondrial 2-oxoglutarate/malate carrier protein 28 P02686 MBP Myelin...”
• Plasma Proteomic Signature of Endometrial Cancer in Patients with Diabetes
  Mujammami, ACS omega 2024
  • “...ratio d ECD/ECND exp e 1 120 P00738 haptoglobin HPT_HUMAN 0.006 1.60 DOWN 2 616 P68871 hemoglobin subunit HBB_HUMAN 0.016 2.72 DOWN 3 247 P02768 albumin ALBU_HUMAN 0.028 1.73 DOWN 4 35 P01023 -2-macroglobulin A2MG_HUMAN 0.05 1.5 UP 5 460 P00738 haptoglobin HPT_HUMAN 0.041 1.66 DOWN...”
• AHP DB: a reference database of proteins in the human aqueous humor.
  Lee, Database : the journal of biological databases and curation 2024
  • “...73.1 100 27 P02765 FETUA Alpha-2-HS-glycoprotein 70 100 28 P04217 A1BG Alpha-1B-glycoprotein 66.48 100 29 P68871 HBB Hemoglobin subunit beta 63.86 52.44 30 P22352 GPX3 Glutathione peroxidase 3 62.06 99.67 31 P01008 ANT3 Antithrombin-III 61.99 100 32 P02749 APOH Beta-2-glycoprotein 1 58 100 33 P06396 GELS...”
• More
• A proteomic analysis identifies candidate early biomarkers to predict ovarian hyperstimulation syndrome in polycystic ovarian syndrome patients.
  Wu, Molecular medicine reports 2017
  • “...H8 13,100 1.53 P02679 Fibrinogen gamma chain 63,883 1.53 P67936 Tropomyosin alpha-4 chain 33,316 1.52 P68872 Hemoglobin subunit beta 14,272 1.52 Q9UBX5 Fibulin-5 19,441 1.50 P02671 Fibrinogen alpha chain 109,041 1.48 Q13790 Apolipoprotein F 39,039 1.42 Q08380 Galectin-3-binding protein 72,286 1.40 P04114 Apolipoprotein B-100 222,441 1.38...”
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P10893 P18972 P22740 P56692 P68030 P68871 P84217 Q3Y9L5 Q6Y239 Q94FT8 P11025 P18973 P22741 P60523 P68031 P68872 P84479 Q3Y9L6 Q6Y257 Q95190 P11251 P18974 P22742 P60524 P68044 P68873 P84604 Q42665 Q760P9 Q95238 P11342 P18975 P22743 P60525 P68045 P68944 P84609 Q42831 Q760Q0 Q95NK8 P11517 P18976 P23016 P60526 P68046 P68945...”
• An approach of orthology detection from homologous sequences under minimum evolution.
  Kim, Nucleic acids research 2008
  • “...of human, P01942 of mouse and P02021 of shark; and (iii) -hemoglobin: P68226, P68871 and P68872 of human, P02088 of mouse and P02143 of shark. We then used Mestortho with the JonesTaylorThornton weight matrix to reconstruct an NJ tree. Confidence interval for MESs of true orthologous...”
  • “...as orthologous groups by Mestortho ( Figure 4 b). The human -hemoglobin sequences P68871 and P68872, which showed no genetic distance to each other, were co-orthologs of P68226 ( Figure 4 a and b). Under the concept of tree reconciliation, two hemoglobin sequences of shark showed...”
• Analysis of the beta-globin gene in DNA of suspected thalassemic great apes.
  Vuch, Genetics and molecular research : GMR 2013 (PubMed)
  • GeneRIF: Pan troglodytes and Pongo pygmaeus were screened for mutations in the beta-globin gene (exons 1, 2, and 3) for suspected thalassemia.
• The action of falciparum malaria on the human and chimpanzee genomes compared: absence of evidence for a genomic signature of malaria at HBB and G6PD in three subspecies of chimpanzee.
  MacFie, Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2009 (PubMed)
  • GeneRIF: We found no evidence of the major deleterious mutations at HBB in chimpanzees that confer resistance to malaria caused by Plasmodium falciparum nor evidence of long-term balancing selection at these loci.

P08223 Hemoglobin subunit epsilon from Eulemur fulvus fulvus
50% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P02074 P02107 P02138 P06642 P08054 P09909 O13078 P01940 P01972 P02003 P02036 P02075 P02108 P02139 P06643 P08223 P0C0U6 O13163 P01941 P01973 P02004 P02038 P02076 P02109 P02140 P07034 P08224 P0C0U7 O13164 P01942 P01975 P02005 P02039 P02077 P02110 P02141 P07035 P08225 P0C0U8 10.1371/journal.pone.0009550.t003 Table 3 SwissProt/UniProt Accession Numbers for...”

Q28338 Hemoglobin subunit epsilon from Cheirogaleus medius
50% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P41329 P67824 P68223 P83134 Q28221 Q6B0K9 Q8AYM0 Q9U6L2 P0C240 P14527 P20244 P41330 P68011 P68224 P83135 Q28338 Q6BBJ0 Q8AYM1 Q9U6L6 P10057 P15162 P20245 P41331 P68012 P68225 P83270 Q28356 Q6BBJ2 Q8BPF4 Q9XSE9 P10058 P15163 P20246 P41332 P68013 P68226 P83271 Q28496 Q6BBK1 Q8BYM1 Q9XSK1 P10059 P15164 P20247 P45718 P68014...”

P33499 Hemoglobin subunit delta from Ateles fusciceps
48% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...Q5I122 Q7Y079 Q9PVM4 P14392 P19789 P30893 P67817 P68078 P82990 Q1AGS8 Q5KSB7 Q7Y1Y1 Q9PVU6 P14520 P19831 P33499 P67818 P68079 P83114 Q1AGS9 Q5MD69 Q7ZT21 Q9TS34 P14521 P19832 P41260 P67819 P68087 P83123 Q1W6G9 Q5RM02 Q803Z5 Q9TS35 P14522 P19885 P41261 P67820 P68168 P83124 Q26505 Q5XLE5 Q862A7 Q9TSN7 P14523 P19886 P41262...”

Q28496 Hemoglobin subunit epsilon from Microcebus murinus
50% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P41331 P68012 P68225 P83270 Q28356 Q6BBJ2 Q8BPF4 Q9XSE9 P10058 P15163 P20246 P41332 P68013 P68226 P83271 Q28496 Q6BBK1 Q8BYM1 Q9XSK1 P10059 P15164 P20247 P45718 P68014 P68227 P83272 Q28507 Q6H1U7 Q8GV40 Q9XSN2 P10060 P15165 P20854 P45719 P68015 P68228 P83273 Q28775 Q6IBF6 Q8GV41 Q9XSN3 P10061 P15166 P20855 P45720 P68016...”

O93349 Hemoglobin subunit beta from Trematomus newnesi
45% identity, 29% coverage

• Proteomic identification of cyclophilin A as a potential biomarker and therapeutic target in oral submucous fibrosis.
  Yuan, Oncotarget 2016
  • “...P12883 Myosin-7 MYH7 223,097/5.63 3 65 P68871 Hemoglobin subunit beta HBB 15,998/ 6.81 30 469 O93349 Hemoglobin subunit beta HBB2_TRENE 16,326/6.03 5 124 P07355 Annexin A2 ANXA2 38,604/ 7.56 10 104 Metabolism P23542 Aspartate aminotransferase, cytoplasmic AAT2 46,058/ 8.45 3 93 P62937 PPIase A PPIA 18,012/7.82...”
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P04240 P07409 P08535 A4GX73 O93348 P01953 P01985 P02015 P02052 P02088 P02121 P04241 P07410 P08849 A6YH87 O93349 P01954 P01986 P02016 P02053 P02089 P02122 P04242 P07411 P08850 A7UAU9 O93351 P01955 P01987 P02017 P02054 P02090 P02123 P04244 P07412 P08851 A9JSP7 O96457 P01956 P01988 P02018 P02055 P02091 P02124 P04245 P07413...”

P15166 Hemoglobin subunit beta from Leptonychotes weddellii
48% identity, 29% coverage

• Eight new Halophytophthora species from marine and brackish-water ecosystems in Portugal and an updated phylogeny for the genus.
  Maia, Persoonia 2022
  • “...only a 18S ribosomal RNA gene sequence (GU994168) and an ITS sequence (GU258844) of isolate P15166 from Thailand could be retrieved from GenBank and an rps10 sequence of the Japanese ex-type isolate CBS 125230 from ( http://oomycetedb.cgrb.oregonstate.edu ) ( Foster et al. 2021 ). BLAST searches...”
  • “...phylogram derived from Bayesian inference analysis of an ITS dataset of Halophytophthora porrigovesica isolate WPC P15166 from Thailand, representative species from all phylogenetic Clades of Phytophthora and Halophytophthora s.str., and representative species from related genera in the Peronosporaceae, Pythiaceae and Salisapiliaceae. Bayesian posterior probabilities and ML...”
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...Q6H1U7 Q8GV40 Q9XSN2 P10060 P15165 P20854 P45719 P68015 P68228 P83273 Q28775 Q6IBF6 Q8GV41 Q9XSN3 P10061 P15166 P20855 P45720 P68016 P68229 P83478 Q28779 Q6LDH0 Q8GV42 Q9XTL1 P10062 P15448 P21197 P45721 P68017 P68230 P83479 Q28931 Q6LDH1 Q8HY34 Q9XTM2 P10777 P15449 P21198 P45722 P68018 P68231 P83611 Q28932 Q6QDC2 Q8QG65...”

P02040 Hemoglobin subunit beta from Cebus albifrons
48% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...Table 2 SwissProt/UniProt Accession Numbers for Hemoglobin dataset Part 1. A1A4Q3 O24520 P01943 P01976 P02006 P02040 P02078 P02111 P02142 P07036 P08256 A1A4Q7 O24521 P01944 P01977 P02007 P02042 P02080 P02112 P02143 P07402 P08257 A1YZP4 O42425 P01945 P01978 P02008 P02044 P02081 P02113 P02208 P07403 P08258 A2TDC2 O76242 P01946...”

A8DUK2 Beta-globin from Mus musculus
48% identity, 28% coverage

• In vivo Protein Corona Formation: Characterizations, Effects on Engineered Nanoparticles' Biobehaviors, and Applications.
  Bai, Frontiers in bioengineering and biotechnology 2021
  • “...Hemoglobin subunit beta-1 (5.79%) Apolipoprotein E (PE = 1 SV = 2) (5.57%) Beta-globin, Hbbt1 (A8DUK2) (4.48%) Hadjidemetriou et al., 2016 115 nm 1 h after intravenous injection SEC and membrane ultrafiltration Apolipoprotein E (PE = 2 SV = 1) (8.19%) Alpha-2-macroglobulin (7.66%) Apolipoprotein C-III (4.86%)...”
  • “...E (PE = 2 SV = 1) (7.30%) Apolipoprotein C-III (6.65%) Alpha-2-macroglobulin (6.42%) Beta-globin, Hbbt1 (A8DUK2) (6.02%) After separation, the characterization methods for protein-bound ENPs and cleaved proteins were similar to that used in in vitro PC analysis. For example, size of PC-ENP complexes can be...”
• Proteomic Analysis of Mucopolysaccharidosis IIIB Mouse Brain
  De, Biomolecules 2020
  • “...CK Q9QYX7 Pclo Protein piccolo 8.4 0.00101 CK, GA Q6P9K8 Caskin1 Caskin-1 3.8 0.00262 CK A8DUK2 Hbbt1 Beta-globin 3.4 0.00008 C Q4VAE3 Tmem65 Transmembrane protein 65 3.3 0.00374 M, PM Q8CHF1 mKIAA0531 Kinesin-like protein (Fragment) 3.2 0.00232 CK P17563 Selenbp1 Selenium-binding protein 1 3.2 0.00046 CK,...”

P02064 Hemoglobin subunit beta-1 from Tapirus terrestris
48% identity, 29% coverage

• Protein signatures as potential surrogate biomarkers for stratification and prediction of treatment response in chronic myeloid leukemia patients.
  Alaiya, International journal of oncology 2016
  • “...3.2576 CMR-Y TKI-Y Hemoglobin beta chain P02027 1 0.04456 16.1529 CMR-N CMR-Y Hemoglobin beta chain P02064 1 0.02202 2.3093 TKI-N CMR-N Hemoglobin beta-1 chain (Major) P02074 b 1 0.00000 4.1199 CMR-N CMR-Y Hemoglobin beta-III chain P19886 b 2 0.00008 2.0278 CMR-N CMR-Y Hemoglobin delta chain P20058...”
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P01930 P01962 P01994 P02025 P02062 P02099 P02130 P04444 P07425 P09423 B2ZUE0 P01932 P01963 P01995 P02026 P02064 P02100 P02131 P06148 P07428 P09839 O02004 P01933 P01964 P01996 P02028 P02065 P02101 P02132 P06467 P07429 P09840 O02480 P01934 P01965 P01997 P02029 P02066 P02102 P02133 P06635 P07430 P09904 O04985 P01935 P01966...”

O93348 Hemoglobin subunit beta-1 from Pagothenia borchgrevinki
45% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P04239 P07408 P08423 A4GTS5 O88754 P01951 P01984 P02014 P02051 P02087 P02120 P04240 P07409 P08535 A4GX73 O93348 P01953 P01985 P02015 P02052 P02088 P02121 P04241 P07410 P08849 A6YH87 O93349 P01954 P01986 P02016 P02053 P02089 P02122 P04242 P07411 P08850 A7UAU9 O93351 P01955 P01987 P02017 P02054 P02090 P02123 P04244 P07412...”

P02094 Hemoglobin subunit beta from Mesocricetus auratus
45% identity, 29% coverage

• A Placenta Derived C-Terminal Fragment of β-Hemoglobin With Combined Antibacterial and Antiviral Activity
  Groß, Frontiers in microbiology 2020
  • “...; Pan troglodytes (Chimpanzee) P68873 ; Bos taurus (Bovine) P02070 ; Mesocricetus auratus (Golden hamster) P02094 ; Ovis aries (Sheep) P02075 ; Macaca fascicularis (Cynomolgus monkey) P68223 ; Panthera pardus orientalis (Amur leopard) P04244 ; Capra hircus (Goat) P02077 ; Bradypus tridactylus (Pale-throated three-toed sloth) P14526...”
• A novel MALDI-TOF MS-based method for blood meal identification in insect vectors: A proof of concept study on phlebotomine sand flies
  Hlavackova, PLoS neglected tropical diseases 2019
  • “...FFESFGDLSTPDAVMGNPK 2058.95 Mouse P02088 VNSDEVGGEALGR 1302.63 YFDSFGDLSSASAIMGNAK 1980.90 Rabbit P02057 VNVEEVGGEALGR 1328.68 FFESFGDLSSANAVMNNPK 2074.95 Hamster P02094 VNADAVGAEALGR 1242.64 FFEHFGDLSSASAVMNNPQVK 2325.10 Grass rat NA VNADQVGGEALGR 1285.65 YFDNFGDLSSASAIMGNAK 2007.91 Cow P02070 VKVDEVGGEALGR 1328.71 FFESFGDLSTADAVMNNPK 2089.95 Sheep P02075 VKVDEVGAEALGR 1342.73 FFEHFGDLSNADAVMNNPK 2152.98 Goat P02077 VKVDEVGAEALGR 1342.73 FFEHFGDLSSADAVMNNAK 2099.95 Dog...”
• Protein signatures as potential surrogate biomarkers for stratification and prediction of treatment response in chronic myeloid leukemia patients.
  Alaiya, International journal of oncology 2016
  • “...5 3.19E-05 976.807 CML-PBP-TKI-Y CML-PBP-No-MMR Hemoglobin chain P11758 6 0.002277 13.0218 CML-PBP-MMR CML-PBP-TKI-N Hemoglobin chain P02094 a 2 0.004366 7.02752 CML-PBP-MMR CML-PBP-TKI-N Hemoglobin -major chain Q28220 4 0.000235 30.7953 CML-PBP-TKI-N CML-PBP-TKI-Y Hemoglobin chain P05546 13 0.005774 2.11422 CML-PBP-TKI-Y CML-PBP-TKI-N Heparin cofactor II precursor (HC-II) P33433 5...”
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P01958 P01990 P02020 P02058 P02093 P02126 P04252 P07415 P09105 B0BL35 P01926 P01959 P01991 P02021 P02059 P02094 P02127 P04346 P07417 P09420 B1H216 P01928 P01960 P01992 P02022 P02060 P02095 P02128 P04442 P07419 P09421 B1Q450 P01929 P01961 P01993 P02024 P02061 P02097 P02129 P04443 P07421 P09422 B2BP38 P01930 P01962 P01994...”

Q95238 Hemoglobin subunit epsilon from Propithecus verreauxi
48% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P68031 P68872 P84479 Q3Y9L6 Q6Y257 Q95190 P11251 P18974 P22742 P60524 P68044 P68873 P84604 Q42665 Q760P9 Q95238 P11342 P18975 P22743 P60525 P68045 P68944 P84609 Q42831 Q760Q0 Q95NK8 P11517 P18976 P23016 P60526 P68046 P68945 P84610 Q43306 Q760Q1 Q966U3 P11748 P18977 P23017 P60529 P68047 P69891 P84611 Q45V69 Q760Q2 Q96FH6...”

G5BYJ8 Hemoglobin subunit beta from Heterocephalus glaber
50% identity, 29% coverage

• Acute Hypoxia Alters Extracellular Vesicle Signatures and the Brain Citrullinome of Naked Mole-Rats (Heterocephalus glaber)
  D'Alessio, International journal of molecular sciences 2022
  • “...G5AXV0 Catalase G5BE53 Vitamin D-binding protein G5BI78 Actin, cytoplasmic 1 G5BQB0 Inhibitor of carbonic anhydrase G5BYJ8 Hemoglobin subunit beta G5B0M6 Keratin, type I cytoskeletal 14 G5AV68 Vitamin K-dependent protein S G5CBM7 Apolipoprotein E G5BT83 Adiponectin G5ALS3 Keratin, type II cytoskeletal 5 G5CAS5 Complement C1s subcomponent G5C3H1...”
  • “...Keratin, type I cytoskeletal 17 V V G5BJ39 Keratin, type II cytoskeletal 8 V V G5BYJ8 Hemoglobin subunit beta V V G5BUN4 Inter-alpha-trypsin inhibitor heavy chain H4 V V G5C0N5 Complement C3 V V G5BSE8 Histone H2A V V G5BV28 Histone H3 V V G5C3H6 Complement...”

P02028 Hemoglobin subunit beta from Chlorocebus aethiops
45% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...B2ZUE0 P01932 P01963 P01995 P02026 P02064 P02100 P02131 P06148 P07428 P09839 O02004 P01933 P01964 P01996 P02028 P02065 P02101 P02132 P06467 P07429 P09840 O02480 P01934 P01965 P01997 P02029 P02066 P02102 P02133 P06635 P07430 P09904 O04985 P01935 P01966 P01998 P02030 P02067 P02103 P02134 P06636 P07431 P09905 O04986 P01936...”

P41332 Hemoglobin subunit beta from Microcephalophis gracilis
45% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...Q9U6L6 P10057 P15162 P20245 P41331 P68012 P68225 P83270 Q28356 Q6BBJ2 Q8BPF4 Q9XSE9 P10058 P15163 P20246 P41332 P68013 P68226 P83271 Q28496 Q6BBK1 Q8BYM1 Q9XSK1 P10059 P15164 P20247 P45718 P68014 P68227 P83272 Q28507 Q6H1U7 Q8GV40 Q9XSN2 P10060 P15165 P20854 P45719 P68015 P68228 P83273 Q28775 Q6IBF6 Q8GV41 Q9XSN3 P10061...”

P08259 Hemoglobin subunit beta from Mandrillus sphinx
45% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P02081 P02113 P02208 P07403 P08258 A2TDC2 O76242 P01946 P01979 P02009 P02046 P02082 P02114 P02209 P07404 P08259 A2TDC3 O76243 P01947 P01980 P02010 P02047 P02083 P02115 P02213 P07405 P08260 A2V8C0 O77655 P01948 P01981 P02011 P02048 P02084 P02116 P04237 P07406 P08261 A2V8C1 O81941 P01949 P01982 P02012 P02049 P02085 P02117...”

XP_004779082 hemoglobin subunit beta from Mustela putorius furo
45% identity, 29% coverage

• Pulse of inflammatory proteins in the pregnant uterus of European polecats (Mustela putorius) leading to the time of implantation
  Lindeberg, Royal Society open science 2017
  • “...proteins for MHC class II antigen presentation in the lysosomal/endosomal system V haemoglobin 15994.3 (none) XP_004779082 430 24 (13) O 2 /CO 2 transport and exchange D, O galectin-3-binding protein 62371.8 (60418.3) XP_004748843 281 22 (9) galectin is a galactose-specific lectin required for terminal differentiation of...”

P68044 Hemoglobin subunit beta from Mustela putorius furo
P68045 Hemoglobin subunit beta from Mustela putorius
45% identity, 29% coverage

• Comparative genomics of canine hemoglobin genes reveals primacy of beta subunit delta in adult carnivores
  Zaldívar-López, BMC genomics 2017
  • “...be incorrectly given as that of HBD ( Mustela putorius furo ; HBB_MUSPF, NCBI accession P68044) [ 37 ]. Ferret HBD was reported to be the only detectable adult -globin [ 38 ]. The other carnivore for which there is expression data, the walrus, also expresses...”
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...Q94FT8 P11025 P18973 P22741 P60523 P68031 P68872 P84479 Q3Y9L6 Q6Y257 Q95190 P11251 P18974 P22742 P60524 P68044 P68873 P84604 Q42665 Q760P9 Q95238 P11342 P18975 P22743 P60525 P68045 P68944 P84609 Q42831 Q760Q0 Q95NK8 P11517 P18976 P23016 P60526 P68046 P68945 P84610 Q43306 Q760Q1 Q966U3 P11748 P18977 P23017 P60529 P68047...”
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...Q95190 P11251 P18974 P22742 P60524 P68044 P68873 P84604 Q42665 Q760P9 Q95238 P11342 P18975 P22743 P60525 P68045 P68944 P84609 Q42831 Q760Q0 Q95NK8 P11517 P18976 P23016 P60526 P68046 P68945 P84610 Q43306 Q760Q1 Q966U3 P11748 P18977 P23017 P60529 P68047 P69891 P84611 Q45V69 Q760Q2 Q96FH6 P11749 P18978 P23018 P60530 P68048...”

Q6WN27 Hemoglobin subunit beta from Pithecia pithecia
45% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P56250 P68026 P68240 P84204 Q3MQ26 Q6WN26 Q946U7 P10883 P18969 P21767 P56251 P68027 P68256 P84205 Q3S3T0 Q6WN27 Q947C5 P10885 P18970 P21768 P56285 P68028 P68257 P84206 Q3TUN7 Q6WN28 Q94FG6 P10892 P18971 P21871 P56691 P68029 P68258 P84216 Q3U0A6 Q6WN29 Q94FT7 P10893 P18972 P22740 P56692 P68030 P68871 P84217 Q3Y9L5 Q6Y239...”

P02035 Hemoglobin subunit beta from Aotus trivirgatus
45% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...O12985 P01938 P01969 P02001 P02033 P02073 P02106 P02137 P06639 P07803 P09908 O13077 P01939 P01971 P02002 P02035 P02074 P02107 P02138 P06642 P08054 P09909 O13078 P01940 P01972 P02003 P02036 P02075 P02108 P02139 P06643 P08223 P0C0U6 O13163 P01941 P01973 P02004 P02038 P02076 P02109 P02140 P07034 P08224 P0C0U7 O13164 P01942...”

Q6WN26 Hemoglobin subunit beta from Aotus azarae
45% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P55267 P68025 P68239 P84203 Q3C1F4 Q6WN25 Q941Q1 P10786 P18707 P21766 P56250 P68026 P68240 P84204 Q3MQ26 Q6WN26 Q946U7 P10883 P18969 P21767 P56251 P68027 P68256 P84205 Q3S3T0 Q6WN27 Q947C5 P10885 P18970 P21768 P56285 P68028 P68257 P84206 Q3TUN7 Q6WN28 Q94FG6 P10892 P18971 P21871 P56691 P68029 P68258 P84216 Q3U0A6 Q6WN29...”

Q6WN25 Hemoglobin subunit beta from Lagothrix lagotricha
45% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P51465 P68024 P68238 P83625 Q3C1F3 Q6WN22 Q941P9 P10785 P18436 P21668 P55267 P68025 P68239 P84203 Q3C1F4 Q6WN25 Q941Q1 P10786 P18707 P21766 P56250 P68026 P68240 P84204 Q3MQ26 Q6WN26 Q946U7 P10883 P18969 P21767 P56251 P68027 P68256 P84205 Q3S3T0 Q6WN27 Q947C5 P10885 P18970 P21768 P56285 P68028 P68257 P84206 Q3TUN7 Q6WN28...”

P68052 Hemoglobin subunit beta from Pteronura brasiliensis
P68053 Hemoglobin subunit beta from Martes foina
45% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...Q9AWA9 P11752 P18983 P23600 P61774 P68051 P69907 P84791 Q45XH6 Q7LZB9 Q9CWS5 P11753 P18984 P23601 P61775 P68052 P80043 P84792 Q45XH7 Q7LZC1 Q9CY06 P11754 P18985 P23602 P61920 P68053 P80044 P85081 Q45XH8 Q7LZC2 Q9CY10 P11755 P18986 P23740 P61921 P68054 P80216 P85082 Q45XI4 Q7LZC3 Q9CZK5 P11756 P18987 P23741 P61947 P68055...”
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...Q9CWS5 P11753 P18984 P23601 P61775 P68052 P80043 P84792 Q45XH7 Q7LZC1 Q9CY06 P11754 P18985 P23602 P61920 P68053 P80044 P85081 Q45XH8 Q7LZC2 Q9CY10 P11755 P18986 P23740 P61921 P68054 P80216 P85082 Q45XI4 Q7LZC3 Q9CZK5 P11756 P18987 P23741 P61947 P68055 P80270 Q03902 Q45XI5 Q7LZL6 Q9D0B2 P11757 P18988 P24291 P61948 P68056...”

P68232 Hemoglobin subunit beta from Ateles geoffroyi
P68234 Hemoglobin subunit beta from Ateles belzebuth
45% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P15449 P21198 P45722 P68018 P68231 P83611 Q28932 Q6QDC2 Q8QG65 Q9Y0D5 P10778 P15469 P21199 P51438 P68019 P68232 P83612 Q29415 Q6R7N2 Q90485 Q9Y0E6 P10780 P16309 P21200 P51440 P68020 P68234 P83613 Q2KPA3 Q6S9E2 Q90486 Q9YGW1 P10781 P16417 P21201 P51441 P68021 P68235 P83614 Q2KPA4 Q6T497 Q90487 Q9YGW2 P10782 P16418 P21379...”
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P15469 P21199 P51438 P68019 P68232 P83612 Q29415 Q6R7N2 Q90485 Q9Y0E6 P10780 P16309 P21200 P51440 P68020 P68234 P83613 Q2KPA3 Q6S9E2 Q90486 Q9YGW1 P10781 P16417 P21201 P51441 P68021 P68235 P83614 Q2KPA4 Q6T497 Q90487 Q9YGW2 P10782 P16418 P21379 P51442 P68022 P68236 P83623 Q2MHE0 Q6WN20 Q90ZM4 P10783 P17689 P21380 P51443...”

P11752 Hemoglobin subunit beta from Megaderma lyra
43% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P69905 P84653 Q45XH3 Q7JFN6 Q98TS0 P11751 P18982 P23020 P61773 P68050 P69906 P84790 Q45XH5 Q7JFR7 Q9AWA9 P11752 P18983 P23600 P61774 P68051 P69907 P84791 Q45XH6 Q7LZB9 Q9CWS5 P11753 P18984 P23601 P61775 P68052 P80043 P84792 Q45XH7 Q7LZC1 Q9CY06 P11754 P18985 P23602 P61920 P68053 P80044 P85081 Q45XH8 Q7LZC2 Q9CY10 P11755...”

Q8AYM1 Hemoglobin beta chain from Thunnus thynnus
45% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P68223 P83134 Q28221 Q6B0K9 Q8AYM0 Q9U6L2 P0C240 P14527 P20244 P41330 P68011 P68224 P83135 Q28338 Q6BBJ0 Q8AYM1 Q9U6L6 P10057 P15162 P20245 P41331 P68012 P68225 P83270 Q28356 Q6BBJ2 Q8BPF4 Q9XSE9 P10058 P15163 P20246 P41332 P68013 P68226 P83271 Q28496 Q6BBK1 Q8BYM1 Q9XSK1 P10059 P15164 P20247 P45718 P68014 P68227 P83272...”

P02032 Hemoglobin subunit beta from Semnopithecus entellus
45% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...O04986 P01936 P01967 P01999 P02031 P02070 P02104 P02135 P06637 P07432 P09906 O09232 P01937 P01968 P02000 P02032 P02072 P02105 P02136 P06638 P07433 P09907 O12985 P01938 P01969 P02001 P02033 P02073 P02106 P02137 P06639 P07803 P09908 O13077 P01939 P01971 P02002 P02035 P02074 P02107 P02138 P06642 P08054 P09909 O13078 P01940...”

1v4wB / Q8AYM1 Crystal structure of bluefin tuna hemoglobin deoxy form at ph7.5 (see paper)
45% identity, 29% coverage

• Ligand: protoporphyrin ix containing fe (1v4wB)

P02066 Hemoglobin subunit beta from Ceratotherium simum
48% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P01933 P01964 P01996 P02028 P02065 P02101 P02132 P06467 P07429 P09840 O02480 P01934 P01965 P01997 P02029 P02066 P02102 P02133 P06635 P07430 P09904 O04985 P01935 P01966 P01998 P02030 P02067 P02103 P02134 P06636 P07431 P09905 O04986 P01936 P01967 P01999 P02031 P02070 P02104 P02135 P06637 P07432 P09906 O09232 P01937 P01968...”

P18707 Hemoglobin subunit beta from Mesocricetus brandti
45% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P83625 Q3C1F3 Q6WN22 Q941P9 P10785 P18436 P21668 P55267 P68025 P68239 P84203 Q3C1F4 Q6WN25 Q941Q1 P10786 P18707 P21766 P56250 P68026 P68240 P84204 Q3MQ26 Q6WN26 Q946U7 P10883 P18969 P21767 P56251 P68027 P68256 P84205 Q3S3T0 Q6WN27 Q947C5 P10885 P18970 P21768 P56285 P68028 P68257 P84206 Q3TUN7 Q6WN28 Q94FG6 P10892 P18971...”

1ch4A / P68871 Module-substituted chimera hemoglobin beta-alpha (f133v) (see paper)
48% identity, 29% coverage

• Ligand: protoporphyrin ix containing fe (1ch4A)

HBB_CHEKU / P80271 Hemoglobin subunit beta; Beta-globin; Hemoglobin beta chain from Chelidonichthys kumu (Bluefin gurnard) (Trigla kumu) (see paper)
48% identity, 29% coverage

• function: Involved in oxygen transport from gills to the various peripheral tissues.
  subunit: Heterotetramer of two alpha chains and two beta chains. Can form polymers.
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P11756 P18987 P23741 P61947 P68055 P80270 Q03902 Q45XI5 Q7LZL6 Q9D0B2 P11757 P18988 P24291 P61948 P68056 P80271 Q0PB48 Q45XI6 Q7LZM6 Q9DF25 P11758 P18989 P24292 P62363 P68057 P80726 Q0PG38 Q45XI7 Q7LZM7 Q9FUD6 P11896 P18990 P24589 P62387 P68058 P80727 Q0WSU5 Q45XI8 Q7LZM8 Q9FVL0 P13273 P18993 P24659 P62741 P68059 P80945...”

P23602 Hemoglobin subunit beta from Mustela lutreola
45% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...Q45XH6 Q7LZB9 Q9CWS5 P11753 P18984 P23601 P61775 P68052 P80043 P84792 Q45XH7 Q7LZC1 Q9CY06 P11754 P18985 P23602 P61920 P68053 P80044 P85081 Q45XH8 Q7LZC2 Q9CY10 P11755 P18986 P23740 P61921 P68054 P80216 P85082 Q45XI4 Q7LZC3 Q9CZK5 P11756 P18987 P23741 P61947 P68055 P80270 Q03902 Q45XI5 Q7LZL6 Q9D0B2 P11757 P18988 P24291...”

P02029 Hemoglobin subunit beta from Theropithecus gelada
45% identity, 29% coverage

• Glutathione Non-Covalent Binding Sites on Hemoglobin and Major Glutathionylation Target betaCys93 Are Conservative among Both Hypoxia-Sensitive and Hypoxia-Tolerant Mammal Species
  Anashkina, International journal of molecular sciences 2023
  • “...and bears Rhinopithecus roxellana HR (A0A2K6Q8D1), Homo sapiens N (P68871), Theropithecus gelada HR (A0A8D2FZZ9 and P02029), Ailurus fulgens HR (P18982) and Ursus thibetanus HR (P68012); (2) European hedgehog and mole Erinaceus europaeus N (A0A1S3AE42, A0A1S3WPY1 and P02059) and Talpa europaea N (P02061); (3) sealiforms Hydrodamalis gigas...”
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...O02004 P01933 P01964 P01996 P02028 P02065 P02101 P02132 P06467 P07429 P09840 O02480 P01934 P01965 P01997 P02029 P02066 P02102 P02133 P06635 P07430 P09904 O04985 P01935 P01966 P01998 P02030 P02067 P02103 P02134 P06636 P07431 P09905 O04986 P01936 P01967 P01999 P02031 P02070 P02104 P02135 P06637 P07432 P09906 O09232 P01937...”

P02044 Hemoglobin subunit delta from Ateles geoffroyi
45% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...O24521 P01944 P01977 P02007 P02042 P02080 P02112 P02143 P07402 P08257 A1YZP4 O42425 P01945 P01978 P02008 P02044 P02081 P02113 P02208 P07403 P08258 A2TDC2 O76242 P01946 P01979 P02009 P02046 P02082 P02114 P02209 P07404 P08259 A2TDC3 O76243 P01947 P01980 P02010 P02047 P02083 P02115 P02213 P07405 P08260 A2V8C0 O77655 P01948...”

P15449 Hemoglobin subunit beta from Mellivora capensis
45% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...Q6LDH0 Q8GV42 Q9XTL1 P10062 P15448 P21197 P45721 P68017 P68230 P83479 Q28931 Q6LDH1 Q8HY34 Q9XTM2 P10777 P15449 P21198 P45722 P68018 P68231 P83611 Q28932 Q6QDC2 Q8QG65 Q9Y0D5 P10778 P15469 P21199 P51438 P68019 P68232 P83612 Q29415 Q6R7N2 Q90485 Q9Y0E6 P10780 P16309 P21200 P51440 P68020 P68234 P83613 Q2KPA3 Q6S9E2 Q90486...”

G7PQY3 Hemoglobin subunit beta from Macaca fascicularis
P68222 Hemoglobin subunit beta from Macaca fuscata fuscata
P68223 Hemoglobin subunit beta from Macaca fascicularis
P68224 Hemoglobin subunit beta from Macaca speciosa
P68225 Hemoglobin subunit beta from Macaca nemestrina
45% identity, 29% coverage

• Gingival Exudatome Dynamics Implicate Inhibition of the Alternative Complement Pathway in the Protective Action of the C3 Inhibitor Cp40 in Nonhuman Primate Periodontitis
  Bostanci, Journal of proteome research 2018
  • “...0.02 1.64 up 0.01 3.07 up G7PQF0 0.01 2.07 down 0.37 0.85 0.01 2.92 up G7PQY3 * 0.02 3.58 down 0.42 1.48 0.02 2.10 up G7PR30 0.03 3.10 down 0.95 1.80 0.12 4.91 G7PR71 0.00 4.79 down 0.10 1.62 0.02 3.17 up G7PRF3 * 0.01 3.14...”
  • “...0.10 0.20 0.11 1.64 0.03 2.14 up G7PPY5 0.35 0.15 0.60 0.54 0.01 2.20 up G7PQY3 * 0.98 1.03 0.01 5.63 down 0.57 4.07 G7PRF3 * 0.18 0.06 0.41 1.68 0.04 1.85 up G7PRZ9 * 0.31 0.19 0.68 0.62 0.04 1.50 up G7PT85 0.41 1.03 0.01...”
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P14524 P20018 P41327 P67822 P68194 P83132 Q27940 Q6AW44 Q8AXX7 Q9TSN9 P0C238 P14525 P20019 P41328 P67823 P68222 P83133 Q28220 Q6AW45 Q8AYL9 Q9TVA3 P0C239 P14526 P20243 P41329 P67824 P68223 P83134 Q28221 Q6B0K9 Q8AYM0 Q9U6L2 P0C240 P14527 P20244 P41330 P68011 P68224 P83135 Q28338 Q6BBJ0 Q8AYM1 Q9U6L6 P10057 P15162 P20245...”
• Exploring Infantile Epileptic Spasm Syndrome: A Proteomic Analysis of Plasma Using the Data-Independent Acquisition Approach.
  Huang, Journal of proteome research 2024
  • “...2 (fragment) 0.57 4.0710 4 down Q86YQ4 HBA1 alpha-1 globin (fragment) 0.56 4.8310 6 down P68223 HBB hemoglobin subunit beta 0.50 2.4410 4 down Q7Z351 DKFZp686N02209 uncharacterized protein DKFZp686N02209 0.50 1.4310 2 down A0A024RAB7 GALE UDP-galactose-4-epimerase, isoform CRA b 0.47 7.2810 8 down GO and KEGG...”
• A Placenta Derived C-Terminal Fragment of β-Hemoglobin With Combined Antibacterial and Antiviral Activity
  Groß, Frontiers in microbiology 2020
  • “...Mesocricetus auratus (Golden hamster) P02094 ; Ovis aries (Sheep) P02075 ; Macaca fascicularis (Cynomolgus monkey) P68223 ; Panthera pardus orientalis (Amur leopard) P04244 ; Capra hircus (Goat) P02077 ; Bradypus tridactylus (Pale-throated three-toed sloth) P14526 ; Ailuropoda melanoleuca (Giant panda) P18983 ; Dasypus novemcinctus (Nine-banded armadillo)...”
• A combined top-down and bottom-up MS approach for the characterization of hemoglobin variants in Rhesus monkeys
  Hüttenhain, Proteomics 2010
  • “...S8); new Uniprot entry suggested for Macaca mulatta 2 15982.5 unknown Hb subunit Macaca fascicularis (P68223) 15983.3 0.8 NEW New Uniprot entry suggested for Macaca mulatta 3 15969.7 unknown Hb subunit Macaca mulatta (P68077) 15970.1 0.4 P68077 4 16275.1 unknown Hb subunit Macaca mulatta (P68077) 15970.1...”
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P14525 P20019 P41328 P67823 P68222 P83133 Q28220 Q6AW45 Q8AYL9 Q9TVA3 P0C239 P14526 P20243 P41329 P67824 P68223 P83134 Q28221 Q6B0K9 Q8AYM0 Q9U6L2 P0C240 P14527 P20244 P41330 P68011 P68224 P83135 Q28338 Q6BBJ0 Q8AYM1 Q9U6L6 P10057 P15162 P20245 P41331 P68012 P68225 P83270 Q28356 Q6BBJ2 Q8BPF4 Q9XSE9 P10058 P15163 P20246...”
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P14526 P20243 P41329 P67824 P68223 P83134 Q28221 Q6B0K9 Q8AYM0 Q9U6L2 P0C240 P14527 P20244 P41330 P68011 P68224 P83135 Q28338 Q6BBJ0 Q8AYM1 Q9U6L6 P10057 P15162 P20245 P41331 P68012 P68225 P83270 Q28356 Q6BBJ2 Q8BPF4 Q9XSE9 P10058 P15163 P20246 P41332 P68013 P68226 P83271 Q28496 Q6BBK1 Q8BYM1 Q9XSK1 P10059 P15164 P20247...”
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P14527 P20244 P41330 P68011 P68224 P83135 Q28338 Q6BBJ0 Q8AYM1 Q9U6L6 P10057 P15162 P20245 P41331 P68012 P68225 P83270 Q28356 Q6BBJ2 Q8BPF4 Q9XSE9 P10058 P15163 P20246 P41332 P68013 P68226 P83271 Q28496 Q6BBK1 Q8BYM1 Q9XSK1 P10059 P15164 P20247 P45718 P68014 P68227 P83272 Q28507 Q6H1U7 Q8GV40 Q9XSN2 P10060 P15165 P20854...”

P14261 Hemoglobin subunit epsilon from Cairina moschata
45% identity, 29% coverage

• Integrative Analysis of CRISPR/Cas9 Target Sites in the Human HBB Gene
  Luo, BioMed research international 2015
  • “...P68873, P69907, Q6LDH1, P01994, P02001, P02007, P02112, P02127, P02128, P02197, P01987, P02003, P04243, P14260, and P14261. ClustalX 1.83 and Mega 3.0 were used to do complete alignment and construct the cladogram. 2.2. CRISPR Target Site and Off-Target Analysis Firstly, to systemically analyze the CRISPR target sites...”
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P81042 Q17155 Q53I65 Q7M3C2 Q9M3U9 P14260 P19014 P28781 P63108 P68064 P81043 Q17156 Q549D9 Q7M413 Q9M593 P14261 P19015 P29623 P63109 P68065 P82111 Q17157 Q549G1 Q7M418 Q9M630 P14387 P19016 P29624 P63110 P68068 P82112 Q17286 Q58L97 Q7M419 Q9PRL9 P14388 P19645 P29625 P63111 P68069 P82113 Q1AGS4 Q5BLF6 Q7M421 Q9PVM1 P14389...”

Q9BWU5 Mutant hemoglobin beta chain (Fragment) from Homo sapiens
48% identity, 40% coverage

• Quantitative Acetylomics Revealed Acetylation-Mediated Molecular Pathway Network Changes in Human Nonfunctional Pituitary Neuroendocrine Tumors
  Wen, Frontiers in endocrinology 2021
  • “...alpha (ID: P69905), K96 (only acetylated in controls) in mutant hemoglobin beta chain (Fragment) (ID: Q9BWU5), K57 (only acetylated in controls) in hemoglobin alpha-1 globin chain (Fragment) ID: E9M4D4), K12 (ratio of T/N=0.37, p =4.29E-02) in alpha globin chain (Fragment) (ID: U3PXP0), K96 (ratio of T/N=0.54,...”
• Dysregulation of SAA1, TUBA8 and Monocytes Are Key Factors in Ankylosing Spondylitis With Femoral Head Necrosis.
  Jiang, Frontiers in immunology 2021
  • “...B S6B2A6 -0.46513 4.526695 -7.36086 4.01E-06 0.01394 4.250422 A0A2S1CVU8 -0.51411 4.593434 -6.28385 2.20E-05 0.038297 2.830983 Q9BWU5 -0.37355 4.476655 -5.78499 5.12E-05 0.04836 2.106727 Q8NFZ7 -0.24071 4.388982 -5.73661 5.56E-05 0.04836 2.034214 ECHDC3 -0.29587 4.431591 -5.39184 0.000102 0.070846 1.505964 G3V1N2 -0.35757 4.596005 -5.25257 0.000131 0.073906 1.286953 PPBP -0.24985 4.372257...”
• Proteomic investigation of protein adsorption to cerebral microdialysis membranes in surgically treated intracerebral hemorrhage patients - a pilot study.
  Tobieson, Proteome science 2020
  • “...8 6.2/11474 M21 # Q6V0K9 Mutant hemoglobin beta chain (Fragment) 76.2 6 6.2/11474 M22 # Q9BWU5 Mutant hemoglobin beta chain (Fragment) 45.7 4 6.5/11501 M23 # C9JKR2 Serum albumin (fragment) 19.7 6 6.0/47288 M24 # Q9BX83 Hemoglobin alpha 1 globin chain (Fragment) 52.0 4 7.1/10710 M25...”
• A Preliminary Proteomic Investigation of Circulating Exosomes and Discovery of Biomarkers Associated with the Progression of Osteosarcoma in a Clinical Model of Spontaneous Disease
  Brady, Translational oncology 2018
  • “...Protein Number Accession Gene Name/Description t 1 E9PGN7 SERPING1 3.90 2 A0A0K0K1H8 HEL-S-71p 3.75 3 Q9BWU5 HBB 3.19 4 P13645 KRT10 2.81 5 B6EDE2 HEL180 2.63 6 P19827 ITIH1 2.22 7 A8K5A4 cDNA FLJ76826 (similar to human gene CP ) 2.08 8 A0A075B6L1 IGLC7 2.08 9...”

Q6V0K9 Mutant hemoglobin beta chain (Fragment) from Homo sapiens
48% identity, 40% coverage

• Proteomic investigation of protein adsorption to cerebral microdialysis membranes in surgically treated intracerebral hemorrhage patients - a pilot study.
  Tobieson, Proteome science 2020
  • “...5.7/13242 M 19 # E9NGZ5 Hemoglobin beta globin chain (Fragment) 93.3 7 5.9/11494 M20 # Q6V0K9 Mutant hemoglobin beta chain (Fragment) 94.3 8 6.2/11474 M21 # Q6V0K9 Mutant hemoglobin beta chain (Fragment) 76.2 6 6.2/11474 M22 # Q9BWU5 Mutant hemoglobin beta chain (Fragment) 45.7 4 6.5/11501...”
  • “...identified as transthyretin (P02766). Spot number 5017 was identified as mutant hemoglobin beta chain, fragment (Q6V0K9). The images are cropped from original gel-images that are displayed in full in Fig. 3 . Abbreviations: OD=optical density; M=membrane; D=dialysate; CSF=cerebrospinal fluid; PHZ=perihemorrhagic zone; SNX=seemingly normal cortex Discussion This...”

P11754 Hemoglobin subunit beta from Cynopterus sphinx
48% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P69907 P84791 Q45XH6 Q7LZB9 Q9CWS5 P11753 P18984 P23601 P61775 P68052 P80043 P84792 Q45XH7 Q7LZC1 Q9CY06 P11754 P18985 P23602 P61920 P68053 P80044 P85081 Q45XH8 Q7LZC2 Q9CY10 P11755 P18986 P23740 P61921 P68054 P80216 P85082 Q45XI4 Q7LZC3 Q9CZK5 P11756 P18987 P23741 P61947 P68055 P80270 Q03902 Q45XI5 Q7LZL6 Q9D0B2 P11757...”

Q14473 Globin domain-containing protein from Homo sapiens
48% identity, 24% coverage

• Proteomic analysis of hypoxia and non-hypoxia secretome mesenchymal stem-like cells from human breastmilk.
  Widjaja, Saudi journal of biological sciences 2021
  • “...Sample A Sample B (n=130) (n=59) Uncharacterized protein A0A2P9AHZ2 A0A2P9AEL2 (n=7) A0A2P9AHG8 Q86T68 A0A2P9ADN6 Q8ND61 Q14473 Identical protein Seven Transmembrane Helix Receptor (n=17) Molybdopterin Oxidoreductase ABO-Antigen Antigen MLAA-10 Arfaptin-2 Serum Albumin Rheumatoid factor RF-IP24 DNA Helicase Vitamin D-binding protein Epididymis Secretory Sperm Binding protein Alpha-fetoprotein SH3...”

P02049 Hemoglobin subunit beta from Nycticebus coucang
45% identity, 29% coverage

• Protein signatures as potential surrogate biomarkers for stratification and prediction of treatment response in chronic myeloid leukemia patients.
  Alaiya, International journal of oncology 2016
  • “...2 2.66E-09 19.544 CML-PBP-MMR CML-PBP-TKI-Y Hemoglobin chain P18984 5 4.21E-09 3.66515 CML-PBP-TKI-Y CML-PBP-MMR Hemoglobin chain P02049 5 3.19E-05 976.807 CML-PBP-TKI-Y CML-PBP-No-MMR Hemoglobin chain P11758 6 0.002277 13.0218 CML-PBP-MMR CML-PBP-TKI-N Hemoglobin chain P02094 a 2 0.004366 7.02752 CML-PBP-MMR CML-PBP-TKI-N Hemoglobin -major chain Q28220 4 0.000235 30.7953 CML-PBP-TKI-N...”
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...O77655 P01948 P01981 P02011 P02048 P02084 P02116 P04237 P07406 P08261 A2V8C1 O81941 P01949 P01982 P02012 P02049 P02085 P02117 P04238 P07407 P08422 A2V8C2 O88752 P01950 P01983 P02013 P02050 P02086 P02118 P04239 P07408 P08423 A4GTS5 O88754 P01951 P01984 P02014 P02051 P02087 P02120 P04240 P07409 P08535 A4GX73 O93348 P01953...”

E9NGZ5 Hemoglobin beta globin chain (Fragment) from Homo sapiens
48% identity, 40% coverage

• Proteomic investigation of protein adsorption to cerebral microdialysis membranes in surgically treated intracerebral hemorrhage patients - a pilot study.
  Tobieson, Proteome science 2020
  • “...Haptoglobin 32.5 9 6.3/276265 M18 # P06702 Protein S100-A9 57.9 6 5.7/13242 M 19 # E9NGZ5 Hemoglobin beta globin chain (Fragment) 93.3 7 5.9/11494 M20 # Q6V0K9 Mutant hemoglobin beta chain (Fragment) 94.3 8 6.2/11474 M21 # Q6V0K9 Mutant hemoglobin beta chain (Fragment) 76.2 6 6.2/11474...”

B3VL05 Beta globin (Fragment) from Homo sapiens
48% identity, 40% coverage

• Proteomic analysis of decidua in patients with recurrent pregnancy loss (RPL) reveals mitochondrial oxidative stress dysfunction
  Yin, Clinical proteomics 2021
  • “...0.0123884 Q96T46 Hemoglobin alpha 2 (Fragment) 0.492646003 0.00386368 Q5T619 Zinc finger protein 648 0.492249489 0.000922952 B3VL05 Beta globin (Fragment) 0.483155107 0.00346729 Q53EU6 Glycerol-3-phosphate acyltransferase 3 0.477888471 0.00394492 B3KUX0 cDNA FLJ40831 fis, clone TRACH2012138, highly similar to Homo sapiens regulator of G-protein signalling 14 (RGS14), mRNA 0.476521157...”

P02030 Hemoglobin subunit beta from Papio cynocephalus
45% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...O02480 P01934 P01965 P01997 P02029 P02066 P02102 P02133 P06635 P07430 P09904 O04985 P01935 P01966 P01998 P02030 P02067 P02103 P02134 P06636 P07431 P09905 O04986 P01936 P01967 P01999 P02031 P02070 P02104 P02135 P06637 P07432 P09906 O09232 P01937 P01968 P02000 P02032 P02072 P02105 P02136 P06638 P07433 P09907 O12985 P01938...”

P83123 Hemoglobin subunit beta from Chelonoidis niger
48% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P14520 P19831 P33499 P67818 P68079 P83114 Q1AGS9 Q5MD69 Q7ZT21 Q9TS34 P14521 P19832 P41260 P67819 P68087 P83123 Q1W6G9 Q5RM02 Q803Z5 Q9TS35 P14522 P19885 P41261 P67820 P68168 P83124 Q26505 Q5XLE5 Q862A7 Q9TSN7 P14523 P19886 P41262 P67821 P68169 P83131 Q27126 Q67XG0 Q86G74 Q9TSN8 10.1371/journal.pone.0009550.t004 Table 4 SwissProt/UniProt Accession Numbers...”

Q6WN29 Hemoglobin subunit beta from Alouatta belzebul
45% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P56285 P68028 P68257 P84206 Q3TUN7 Q6WN28 Q94FG6 P10892 P18971 P21871 P56691 P68029 P68258 P84216 Q3U0A6 Q6WN29 Q94FT7 P10893 P18972 P22740 P56692 P68030 P68871 P84217 Q3Y9L5 Q6Y239 Q94FT8 P11025 P18973 P22741 P60523 P68031 P68872 P84479 Q3Y9L6 Q6Y257 Q95190 P11251 P18974 P22742 P60524 P68044 P68873 P84604 Q42665 Q760P9...”

A9JSP7 Hemoglobin, epsilon 1 from Xenopus tropicalis
P08423 Hemoglobin subunit beta-2 from Xenopus tropicalis
48% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P02122 P04242 P07411 P08850 A7UAU9 O93351 P01955 P01987 P02017 P02054 P02090 P02123 P04244 P07412 P08851 A9JSP7 O96457 P01956 P01988 P02018 P02055 P02091 P02124 P04245 P07413 P08852 A9XDF6 P01923 P01957 P01989 P02019 P02057 P02092 P02125 P04246 P07414 P08853 B0BL34 P01924 P01958 P01990 P02020 P02058 P02093 P02126 P04252...”
• Deep Learning-Based Diagnosing Structural Behavior in Dam Safety Monitoring System.
  Wang, Sensors (Basel, Switzerland) 2021
  • “...of the nodes P04618 and P07590 has a relative high correlation coefficient than that of P08423 and vice versa. With other nodes ranked by their correlation coefficients with P08423 in descending order, we select three correlation node sequence through the sliding window (namely, the number of...”
  • “...legends of the solid circle, triangle, and rhombus correspond to the nodes P04618, P07590, and P08423, respectively. Overall, the average RMSE curve goes down as the Coef increases. As displayed by the grey column in the figure, when the Coef threshold ranges between 0.8 and 0.825,...”
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P02085 P02117 P04238 P07407 P08422 A2V8C2 O88752 P01950 P01983 P02013 P02050 P02086 P02118 P04239 P07408 P08423 A4GTS5 O88754 P01951 P01984 P02014 P02051 P02087 P02120 P04240 P07409 P08535 A4GX73 O93348 P01953 P01985 P02015 P02052 P02088 P02121 P04241 P07410 P08849 A6YH87 O93349 P01954 P01986 P02016 P02053 P02089 P02122...”
• Thirty-ninth Annual Meeting February 12-16, 1995 Moscone Center San Francisco, California : Wednesday Symposia and Posters, Part IV
  , Biophysical journal 1995

P19885 Hemoglobin subunit beta from Colobus polykomos
45% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...Q1AGS9 Q5MD69 Q7ZT21 Q9TS34 P14521 P19832 P41260 P67819 P68087 P83123 Q1W6G9 Q5RM02 Q803Z5 Q9TS35 P14522 P19885 P41261 P67820 P68168 P83124 Q26505 Q5XLE5 Q862A7 Q9TSN7 P14523 P19886 P41262 P67821 P68169 P83131 Q27126 Q67XG0 Q86G74 Q9TSN8 10.1371/journal.pone.0009550.t004 Table 4 SwissProt/UniProt Accession Numbers for Myoglobin dataset. O77003 P02159 P02174...”

P02126 Hemoglobin subunit beta from Sturnus vulgaris
48% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P01989 P02019 P02057 P02092 P02125 P04246 P07414 P08853 B0BL34 P01924 P01958 P01990 P02020 P02058 P02093 P02126 P04252 P07415 P09105 B0BL35 P01926 P01959 P01991 P02021 P02059 P02094 P02127 P04346 P07417 P09420 B1H216 P01928 P01960 P01992 P02022 P02060 P02095 P02128 P04442 P07419 P09421 B1Q450 P01929 P01961 P01993 P02024...”

1wmuB / P83133 Crystal structure of hemoglobin d from the aldabra giant tortoise, geochelone gigantea, at 1.65 a resolution
P83133 Hemoglobin A/D subunit beta from Aldabrachelys gigantea
48% identity, 29% coverage

• Ligand: protoporphyrin ix containing fe (1wmuB)
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P20018 P41327 P67822 P68194 P83132 Q27940 Q6AW44 Q8AXX7 Q9TSN9 P0C238 P14525 P20019 P41328 P67823 P68222 P83133 Q28220 Q6AW45 Q8AYL9 Q9TVA3 P0C239 P14526 P20243 P41329 P67824 P68223 P83134 Q28221 Q6B0K9 Q8AYM0 Q9U6L2 P0C240 P14527 P20244 P41330 P68011 P68224 P83135 Q28338 Q6BBJ0 Q8AYM1 Q9U6L6 P10057 P15162 P20245 P41331...”

P02038 Hemoglobin subunit beta from Saguinus mystax
45% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...O13078 P01940 P01972 P02003 P02036 P02075 P02108 P02139 P06643 P08223 P0C0U6 O13163 P01941 P01973 P02004 P02038 P02076 P02109 P02140 P07034 P08224 P0C0U7 O13164 P01942 P01975 P02005 P02039 P02077 P02110 P02141 P07035 P08225 P0C0U8 10.1371/journal.pone.0009550.t003 Table 3 SwissProt/UniProt Accession Numbers for Hemoglobin dataset Part 2. P0C237 P14524...”

4f4oB / P02067 Structure of the haptoglobin-haemoglobin complex (see paper)
45% identity, 29% coverage

• Ligand: protoporphyrin ix containing fe (4f4oB)

P02039 Hemoglobin subunit beta from Leontocebus fuscicollis
45% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...O13163 P01941 P01973 P02004 P02038 P02076 P02109 P02140 P07034 P08224 P0C0U7 O13164 P01942 P01975 P02005 P02039 P02077 P02110 P02141 P07035 P08225 P0C0U8 10.1371/journal.pone.0009550.t003 Table 3 SwissProt/UniProt Accession Numbers for Hemoglobin dataset Part 2. P0C237 P14524 P20018 P41327 P67822 P68194 P83132 Q27940 Q6AW44 Q8AXX7 Q9TSN9 P0C238 P14525...”

NP_001138313 hemoglobin subunit beta from Sus scrofa
P02067 Hemoglobin subunit beta from Sus scrofa
45% identity, 29% coverage

• Molecular insights into the interaction of hemorphin and its targets
  Ali, Scientific reports 2019
  • “...of Homo sapiens (NP_000509), Camelus dromedarius (XP_010988890), Equus caballus (XP_001504239), Bos taurus (NP_776342), Sus scrofa (NP_001138313), Ovis aries (NP_001091117), Pan troglodytes (NC_036890) and Oryctolagus cuniculus (NP_001075729) were retrieved from NCBI protein database. Multiple sequence alignment of these sequences was performed using ClustalW 75 . Protein structure...”
• Hemoglobin subunit beta interacts with the capsid protein and antagonizes the growth of classical swine fever virus.
  Li, Journal of virology 2013
  • GeneRIF: In this study, hemoglobin subunit beta was identified as a classical swine fever virus capsid protein-binding protein by glutathione S-transferase pulldown and subsequent mass spectrometry analysis of PK-15 cells.
• Large-Scale Protein Analysis of Experimental Retinal Artery Occlusion
  Vestergaard, International journal of molecular sciences 2023
  • “...Filamin-B FLNB <0.00001 3.65 P00450 Ceruloplasmin CP 0.00406 3.46 P18650 Apolipoprotein E APOE <0.00001 3.39 P02067 Hemoglobin subunit beta HBB 0.00010 Day 1 + Day 3 3.07 O62839 Catalase CAT 0.00171 3.01 Q6P1M3 Lethal(2) giant larvae protein homolog 2 LLGL2 <0.00001 Day 3 2.91 Q764M5 Signal...”
• How Discoloration of Porcine Cruor Hydrolysate Allowed the Identification of New Antifungal Peptides.
  Cournoyer, Foods (Basel, Switzerland) 2022
  • “...and 16,036 Da, corresponding, respectively to the -chain and -chain of the porcine hemoglobin (UniProtKB, P02067 and P01965). This fact was confirmed during the DH analysis which showed that no plateau was reached at final time of hydrolysis ( Figure 1 ). The hydrolysis could be...”
  • “...Amino acid sequence of porcine hemoglobin, chain and chain. Adapted from UniProtKB, Code: HP beta P02067, HP alpha P01965, HB beta P02070 and HB alpha P01966 [ 44 ]. Red amino acids are different in the bovine hemoglobin sequence. Figure 6 Inhibition zones for yeasts C....”
• Functional Analysis and Proteomics Profiling of Extracellular Vesicles From Swine Plasma Infected by African Swine Fever Virus.
  Xu, Frontiers in cellular and infection microbiology 2022
  • “...I3LQ17 PZP 0.033 A0A4X1VBD2 C4A 0.006 L8AXM9 IGHG 0.020 A0A4X1UG39 SERPINC1 0.003 F1RII7 HBB 0.015 P02067 HBB 0.037 Q8WMN8 LTF 0.039 A0A480Y8T9 0.048 P01965 HBA 0.049 K7ZPU8 IGHG5-1 0.033 A0A4X1SL55 0.004 A0A287A7G8 0.001 P62802 0.012 Q8HZV3 TFRC 0.033 P32194 NPG1 0.026 F6Q697 S100A9 0.008 P80310 S100A12...”
• Characterization and Safety Profile of Transfer Factors Peptides, a Nutritional Supplement for Immune System Regulation
  Polonini, Biomolecules 2021
  • “...of Imuno TF . Proteome Identifier (UPID) Gene Name Description P01965 HBA Hemoglobin subunit alpha P02067 HBB Hemoglobin subunit beta P02067 HBB Hemoglobin subunit beta F1SFZ8 TLN1 Talin-1 A0A287AZA7 RPS27A 40S ribosomal protein S27a (Ubiquitin-40S ribosomal protein S27a) A0A5K1UHC4 AGPAT5 PlsC domain-containing protein P01965 HBA Hemoglobin...”
• "In vitro" Effect of Different Follicle-Stimulating Hormone Preparations on Sertoli Cells: Toward a Personalized Treatment for Male Infertility
  Arato, Frontiers in endocrinology 2020
  • “...6.72 1 1 1 15.3 P29412 EEF1B Elongation factor 1-beta 6.70 1 1 1 24.6 P02067 HBB Hemoglobin subunit beta 6.12 1 1 1 16.2 O02705 HSP90AA1 Heat shock protein HSP 90-alpha 1.91 1 1 1 84.7 P03970 INHBA Inhibin beta A chain 7.08 1 2...”
  • “...P62936 PPIA Peptidyl-prolyl cis-trans isomerase A 1.358 1.980 1.076 P14287 SPP1 Osteopontin 1.016 2.134 1.191 P02067 HBB Hemoglobin subunit beta 1.270 1.814 1.336 P80928 MIF Macrophage migration inhibitory factor 1.412 1.513 1.233 Q2EN75 S100A6 Protein S100-A6 1.302 1.564 1.100 P20112 SPARC SPARC 0.589 0.474 0.485 P62802...”
• A Placenta Derived C-Terminal Fragment of β-Hemoglobin With Combined Antibacterial and Antiviral Activity
  Groß, Frontiers in microbiology 2020
  • “...P68871 ; Rattus norvegicus (Rat) P02091 ; Mus musculus (Mouse) P02088 ; Sus scrofa (Pig) P02067 ; Oryctolagus cuniculus (Rabbit) P02057 ; Pan troglodytes (Chimpanzee) P68873 ; Bos taurus (Bovine) P02070 ; Mesocricetus auratus (Golden hamster) P02094 ; Ovis aries (Sheep) P02075 ; Macaca fascicularis (Cynomolgus...”
• Evaluating nursery pig responses to in-feed sub-therapeutic antibiotics
  Helm, PloS one 2019
  • “...0.002 Glucose-6-phosphate isomerase P08059 0.312 0.018 Hemoglobin subunit alpha P01965 0.555 0.046 Hemoglobin subunit beta P02067 0.651 0.028 Hemopexin P50828 0.609 0.016 High mobility group protein B1 P12682 0.502 0.017 High mobility group protein B2 P17741 0.557 0.048 Metallothionein-2A P79379 1.170 0.012 Peroxiredoxin-2 (Fragment) P52552 0.197...”
• A Decellularized Porcine Xenograft-Derived Bone Scaffold for Clinical Use as a Bone Graft Substitute: A Critical Evaluation of Processing and Structure
  Bracey, Journal of functional biomaterials 2018
  • “...vessel remodeling, and cytokine signaling Annexin A5 P08758 3/3 0/3 Blood coagulation Hemoglobin subunit beta P02067 P68871 2/3 0/3 Highly abundant blood protein, oxygen transport Alpha-1-antiproteinase P50447 P01009 2/3 0/3 Serine protease inhibitor; found in high levels in blood Vitronectin P48819 P04004 0/3 3/3 Cell adhesion...”
• More

P68054 Hemoglobin subunit beta from Leontocebus nigricollis
P68055 Hemoglobin subunit beta from Saguinus oedipus
45% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...Q9CY06 P11754 P18985 P23602 P61920 P68053 P80044 P85081 Q45XH8 Q7LZC2 Q9CY10 P11755 P18986 P23740 P61921 P68054 P80216 P85082 Q45XI4 Q7LZC3 Q9CZK5 P11756 P18987 P23741 P61947 P68055 P80270 Q03902 Q45XI5 Q7LZL6 Q9D0B2 P11757 P18988 P24291 P61948 P68056 P80271 Q0PB48 Q45XI6 Q7LZM6 Q9DF25 P11758 P18989 P24292 P62363 P68057...”
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...Q9CY10 P11755 P18986 P23740 P61921 P68054 P80216 P85082 Q45XI4 Q7LZC3 Q9CZK5 P11756 P18987 P23741 P61947 P68055 P80270 Q03902 Q45XI5 Q7LZL6 Q9D0B2 P11757 P18988 P24291 P61948 P68056 P80271 Q0PB48 Q45XI6 Q7LZM6 Q9DF25 P11758 P18989 P24292 P62363 P68057 P80726 Q0PG38 Q45XI7 Q7LZM7 Q9FUD6 P11896 P18990 P24589 P62387 P68058...”

B5ANL9 Beta globin chain (Fragment) from Homo sapiens
48% identity, 48% coverage

• Dysregulation of SAA1, TUBA8 and Monocytes Are Key Factors in Ankylosing Spondylitis With Femoral Head Necrosis.
  Jiang, Frontiers in immunology 2021
  • “...-3.13958 HEL-S-103 -0.1541 4.646185 -2.67057 0.018533 0.271647 -3.16211 RAD23A -0.16841 4.413893 -2.64289 0.019555 0.271647 -3.20985 B5ANL9 -0.23888 4.34086 -2.63904 0.019702 0.271647 -3.21649 DKFZp686A0568 -0.22009 4.434658 -2.63806 0.019739 0.271647 -3.21818 A0A2U8J907 -0.24425 4.448972 -2.63584 0.019825 0.271647 -3.222 SSR2 -0.19211 4.360938 -2.58286 0.021964 0.282364 -3.31292 C1QBP 0.163145 4.652796...”

F8W6P5 Hemoglobin subunit beta (Fragment) from Homo sapiens
48% identity, 47% coverage

• Human amyloid-β enriched extracts: evaluation of in vitro and in vivo internalization and molecular characterization.
  Pedrero-Prieto, Alzheimer's research & therapy 2019
  • “...finger protein 213 A0A0A0MTR7 4 RPL4 Ribosomal protein L4 H3BM89 4 HBB Hemoglobin subunit beta F8W6P5 3 MAPT Microtubule associated protein tau I3L170 3 NME1-NME2 NME1-NME2 readthrough J3KPD9 3 PIK3R2 Phosphoinositide-3-kinase regulatory subunit 2 E9PFP1 3 SEPT2 Septin 2 B5MCX3 3 SYNE2 Spectrin repeat containing nuclear...”
• Potential Utility of Protein Targets of Cysteine-S-Nitrosylation in Identifying Clinical Disease Status in Human Chagas Disease.
  Zago, Frontiers in microbiology 2018
  • “...ACTB B4E335 468 1.08 1.10 1.05 1.19 1.03 1.16 384 4.0 29 LVV-hemorphin-7 = HBB F8W6P5 47 1.09 1.20 1.03 1.10 1.07 1.17 385 5.7 29 Vimentin = VIM F5H288 171 1.22 1.10 1.28 1.34 1.05 1.40 389 6.1 28 Annexin A3 = ANXA3 P12429 549...”
  • “...ENO3 E5RGZ4 63 1.24 1.15 1.01 1.07 1.22 1.14 703 7.7 12 LVV-hemorphin-7 = HBB F8W6P5 41 1.13 1.85 1.29 1.64 1.14 1.44 704 8.1 12 SH3 domain-binding glutamic acid-rich-like protein 2 = SH3BGRL2 Q9UJC5 314 1.24 1.60 1.31 1.99 1.62 1.23 706 6.7 12 Protein...”
• Proteins and their modifications in a medieval mummy
  Mikšík, Protein science : a publication of the Protein Society 2016
  • “...P02461 P13942 P20908 P05997 P08572 P69905 P02792 F8W6P5 P21810 P04004 P00734 P02818 P68871 P36955 Protein Collagen alpha-1(I) chain Collagen alpha-2(I) chain...”
• S-Nitrosylation Proteome Profile of Peripheral Blood Mononuclear Cells in Human Heart Failure.
  Koo, International journal of proteomics 2016
  • “...Annexin A1 GN=ANXA1 P04083 200 1.18 2.15 1.13 1.91 384 4.02 29 L10 LVV-hemorphin-7 GN=HBB F8W6P5 47 1.09 1.57 1.98 3.12 385 5.72 29 102 Vimentin GN=VIM F5H288 171 1.22 1.36 1.20 1.63 395 6.85 27 E8 Keratin, type II cytoskeletal 2 GN=KRT2 P35908 381 1.46...”
  • “...beta GN=HBB P68871 384 1.15 1.12 1.50 1.68 703 7.72 12 D3 LVV-hemorphin-7 (fragment) GN=HBB F8W6P5 41 1.13 1.09 1.49 1.63 706 6.70 12 E16 Protein S100-A11 GN=S100A11 P31949 260 1.39 1.27 1.75 2.22 718 4.53 11 C4 Ras-related protein Ral-B GN=RALB (actin cytoplasmic 2 GN=ACTG1)...”
• Changes in Proteome Profile of Peripheral Blood Mononuclear Cells in Chronic Chagas Disease.
  Garg, PLoS neglected tropical diseases 2016
  • “...3.67 Lactotransferrin Delta LTF P02788-2 825 8.65 72 147 1.58E-10 1.59 1.73 CP LVV-hemorphin-7 HBB F8W6P5 703 7.72 12 41 6.29E+00 2.20 ND CP 867 4.91 0 65 2.51E-02 3.95 4.61 804 6.96 10 122 5.00E-08 1.74 1.62 879 6.87 11 213 3.97E-17 2.35 1.87 Mitochondrial...”

P68047 Hemoglobin subunit beta from Arctocephalus galapagoensis
P68046 Hemoglobin subunit beta from Odobenus rosmarus divergens
45% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...Q95NK8 P11517 P18976 P23016 P60526 P68046 P68945 P84610 Q43306 Q760Q1 Q966U3 P11748 P18977 P23017 P60529 P68047 P69891 P84611 Q45V69 Q760Q2 Q96FH6 P11749 P18978 P23018 P60530 P68048 P69892 P84652 Q45V70 Q78PA4 Q98905 P11750 P18981 P23019 P61772 P68049 P69905 P84653 Q45XH3 Q7JFN6 Q98TS0 P11751 P18982 P23020 P61773 P68050...”
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...Q95238 P11342 P18975 P22743 P60525 P68045 P68944 P84609 Q42831 Q760Q0 Q95NK8 P11517 P18976 P23016 P60526 P68046 P68945 P84610 Q43306 Q760Q1 Q966U3 P11748 P18977 P23017 P60529 P68047 P69891 P84611 Q45V69 Q760Q2 Q96FH6 P11749 P18978 P23018 P60530 P68048 P69892 P84652 Q45V70 Q78PA4 Q98905 P11750 P18981 P23019 P61772 P68049...”

Q7M2Y5 Hemoglobin subunit beta-2 from Chalinolobus morio
45% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P62741 P68059 P80945 Q0ZA50 Q45XI9 Q7M2Y4 Q9FY42 P13274 P18994 P24660 P62742 P68060 P80946 Q10732 Q45XJ0 Q7M2Y5 Q9GJS7 P13557 P18995 P26915 P63105 P68061 P81023 Q10733 Q4F6Z2 Q7M3B6 Q9GLX4 P13558 P18996 P26916 P63106 P68062 P81024 Q17153 Q4VIX3 Q7M3B8 Q9I9I3 P14259 P19002 P28780 P63107 P68063 P81042 Q17155 Q53I65 Q7M3C2...”

Q0Z944 Beta globin (Fragment) from Homo sapiens
48% identity, 40% coverage

• Proteomic Analysis Reveals Commonly Secreted Proteins of Mesenchymal Stem Cells Derived from Bone Marrow, Adipose Tissue, and Synovial Membrane to Show Potential for Cartilage Regeneration in Knee Osteoarthritis.
  Lee, Stem cells international 2021
  • “...P63261 Actin, cytoplasmic 2 ACTG1 P63313 Thymosin beta-10 TMSB10 Q01995 Transgelin TAGLN Q08629 Testican-1 SPOCK1 Q0Z944 Beta globin HBB Q12841 Follistatin-related protein 1 FSTL1 Q14767 Latent-transforming growth factor beta-binding protein 2 LTBP2 Q15582 Transforming growth factor-beta-induced protein ig-h3 1 TGFBI Q16270 Insulin-like growth factor-binding protein 7...”

6hitB / B3F9D7 The crystal structure of haemoglobin from atlantic cod (see paper)
48% identity, 29% coverage

• Ligand: protoporphyrin ix containing fe (6hitB)

Q8IZI0 Hemoglobin beta chain variant Hb-I_Toulouse (Fragment) from Homo sapiens
48% identity, 40% coverage

• Proteomics Defines Plasma Biomarkers for the Early Diagnosis of Biliary Atresia
  Fu, Journal of proteome research 2024
  • “...0.025 A0A5C2GB83 IGH + IGL c526_heavy_IGHV1-69_IGHD1-26_IGHJ6 (fragment) 0.62 0.025 A0A024R9Q1 thrombospondin-1, isoform CRA_a 0.60 0.005 Q8IZI0 hemoglobin beta chain variant Hb-I_Toulouse (fragment) 0.58 0.013 A0A024R930 proteoglycan4, isoform CRA_a 0.57 0.005 B3KQF4 cDNA FLJ90373 fis, clone NT2RP2004606, highly similar to metalloproteinaseinhibitor1 0.57 0.007 Q13201 multimerin-1 0.56 3.9910...”
• Identification and Verification of the Main Differentially Expressed Proteins in Gastric Cancer via iTRAQ Combined with Liquid Chromatography-Mass Spectrometry
  Gao, Analytical cellular pathology (Amsterdam) 2019
  • “...HLA class II histocompatibility antigen, DMbeta chain OS=Homo sapiens PE=2 SV=1 (B4DVC2_HUMAN) 1.592926 0.001811 47 Q8IZI0 Hemoglobin beta chain variant Hb-I_Toulouse (fragment) OS=Homo sapiens GN=HBB PE=3 SV=1 (Q8IZI0_HUMAN) 1.592452 0.001823 48 Q6P1N7 TAPBP protein OS=Homo sapiens GN=TAPBP PE=1 SV=1 (Q6P1N7_HUMAN) 1.584238 0.002054 49 B4DNT5 cDNA FLJ60316,...”
• Proteomic analysis of human aqueous humor using multidimensional protein identification technology.
  Richardson, Molecular vision 2009
  • “...Yes 26 4 2.10E-06 NSCPPTSELLGTSDR P00739 Haptoglobin-related protein, Isoform 1 Yes 39 4 5.42E-06 AVGDKLPECEAVCGKPK Q8IZI0 Hemoglobin beta chain variant Hb-I Toulouse NF 12 7 3.31E-08 VNVDEVGGEALGR P69905 Hemoglobin subunit alpha [ 5 ] Yes 15 5 4.97E-11 VGAHAGEYGAEALER P68871 Hemoglobin subunit beta [ 5 ]...”

P02033 Hemoglobin subunit beta from Piliocolobus badius
45% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...O09232 P01937 P01968 P02000 P02032 P02072 P02105 P02136 P06638 P07433 P09907 O12985 P01938 P01969 P02001 P02033 P02073 P02106 P02137 P06639 P07803 P09908 O13077 P01939 P01971 P02002 P02035 P02074 P02107 P02138 P06642 P08054 P09909 O13078 P01940 P01972 P02003 P02036 P02075 P02108 P02139 P06643 P08223 P0C0U6 O13163 P01941...”

Q28356 Hemoglobin subunit epsilon from Daubentonia madagascariensis
45% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P41330 P68011 P68224 P83135 Q28338 Q6BBJ0 Q8AYM1 Q9U6L6 P10057 P15162 P20245 P41331 P68012 P68225 P83270 Q28356 Q6BBJ2 Q8BPF4 Q9XSE9 P10058 P15163 P20246 P41332 P68013 P68226 P83271 Q28496 Q6BBK1 Q8BYM1 Q9XSK1 P10059 P15164 P20247 P45718 P68014 P68227 P83272 Q28507 Q6H1U7 Q8GV40 Q9XSN2 P10060 P15165 P20854 P45719 P68015...”

Q8IUL9 Hemoglobin beta chain variant Hb.Sinai-Bel Air (Fragment) from Homo sapiens
48% identity, 40% coverage

• iTRAQ and PRM-Based Proteomic Analysis Provides New Insights into Mechanisms of Response to Triple Therapy in Patients with Rheumatoid Arthritis
  Chen, Journal of inflammation research 2021
  • “...0.00018 F8WCJ1 EIF5A2 Eukaryotic translation initiation factor 5A 1.641945 0.000251 P30041 PRDX6 Peroxiredoxin-6 1.57379 0.000811 Q8IUL9 HBB Hemoglobin beta chain variant Hb. Sinai-Bel Air (Fragment) 1.565149 0.000938 H0YID2 AK1 Adenylate kinase isoenzyme 1 (Fragment) 1.539678 0.001434 P30043 BLVRB Flavin reductase (NADPH) 1.529225 0.001704 * P02533 KRT14...”
• Proteomic analysis of decidua in patients with recurrent pregnancy loss (RPL) reveals mitochondrial oxidative stress dysfunction
  Yin, Clinical proteomics 2021
  • “...0.00838654 Q86YQ4 Alpha-1 globin (Fragment) 0.589155294 0.0180772 Q9HC84 Mucin-5B 0.588815297 0.00462402 P16157 Ankyrin-1 0.588481678 0.00719774 Q8IUL9 Hemoglobin beta chain variant Hb.Sinai-Bel Air (Fragment) 0.587167978 0.00647221 E5RGQ0 Dematin (Fragment) 0.58673237 0.00406203 A0A024R674 Spectrin, beta, erythrocytic (Includes spherocytosis, clinical type I), isoform CRA_e 0.582545212 0.0237601 J3QL31 Nuclear distribution...”
• Dysferlin and other non-red cell proteins accumulate in the red cell membrane of Diamond-Blackfan Anemia patients.
  Pesciotta, PloS one 2014
  • “...GeneName Protein Description PeptideCount FoldChange D1 FoldChange D2 FoldChange D3 FoldChange D4 Outside 95% Interval Q8IUL9 HBB Hemoglobin beta chain 13 2.6 2.2 2.7 3.8 D14 P02042 HBD Hemoglobin subunit delta 8 3.1 3.1 3.4 4.5 D14 E9PDY4 CR1 Complement receptor type 1 11 [100] *...”

Q14484 Beta-globin (Fragment) from Homo sapiens
48% identity, 69% coverage

• Dysregulation of SAA1, TUBA8 and Monocytes Are Key Factors in Ankylosing Spondylitis With Femoral Head Necrosis.
  Jiang, Frontiers in immunology 2021
  • “...-2.69714 Q53G99 -0.15021 4.299872 -2.90759 0.011668 0.223388 -2.74874 CRTAP 0.219215 4.664599 2.904973 0.011728 0.223388 -2.75333 Q14484 -0.17371 4.368887 -2.9016 0.011806 0.223388 -2.75926 U3PXP0 -0.15042 4.527014 -2.90103 0.011819 0.223388 -2.76026 CHD7 -0.15117 4.521314 -2.8952 0.011955 0.223388 -2.77052 B3VL28 -0.21876 4.362942 -2.88561 0.012182 0.223388 -2.78736 HSPA12B -0.16956 4.34589...”
• Salivary Cytoprotective Proteins in Inflammation and Resolution during Experimental Gingivitis--A Pilot Study
  Aboodi, Frontiers in cellular and infection microbiology 2015
  • “...0.042 Q12912 Lymphoid-restricted membrane protein 1.21 0.001 Q12955 Ankyrin-3 0.07 0.001 Q14118 Dystroglycan 0.68 0.005 Q14484 Beta-globin 3.75 0.001 Q14515 SPARC-like protein 1 2.10 0.005 Q14C71 GLRA1 protein 1.41 0.032 Q16378 Proline-rich protein 4 0.93 0.008 Q502W4 IGKC protein 1.57 0.013 Q569J1 IGHA1 protein 1.33 0.026...”
  • “...P10599 Thioredoxin 2.29 0.000 P27482 Calmodulin-like protein 3 2.11 0.000 Q05BP9 OLIG2 protein 2.47 0.042 Q14484 Beta-globin 3.75 0.001 Q14515 SPARC-like protein 1 2.10 0.005 Q6W4X9 Mucin-6 2.13 0.045 Q96AY4 Tetratricopeptide repeat protein 28 2.20 0.020 Q9BZG5 Androgen receptor 2.21 0.002 Highlighted proteins are proteins considered...”
• Serum proteome changes in acromegalic patients following transsphenoidal surgery: novel biomarkers of disease activity
  Cruz-Topete, European journal of endocrinology 2011
  • “...C 6.2/20 Haptoglobin a2 P00738 K39.92 103 39 10/47 394 22 6/59 D 7.8/12 b-Hemoglobin Q14484 K22.67 66 58 8/31 64 6 6/31 E 5.0/10 ApoA-1 P02647 K33.65 158 48 14/38 170 24 5/52 F 5.4/10 ApoA-1 P02647 K28.24 160 51 15/39 292 26 6/53 G...”

Q3LR79 Hemoglobin beta (Fragment) from Homo sapiens
48% identity, 40% coverage

• Proteomic analysis of decidua in patients with recurrent pregnancy loss (RPL) reveals mitochondrial oxidative stress dysfunction
  Yin, Clinical proteomics 2021
  • “...chain variant (Fragment) 0.391928242 0.000403159 G3V1N2 HCG1745306, isoform CRA_a 0.381102252 0.00686417 E9PJK3 Myomegalin 0.374237369 0.00223712 Q3LR79 Hemoglobin beta (Fragment) 0.373133311 0.0106368 Q52MT0 Beta globin (Fragment) 0.36879883 0.00906274 P02042 Hemoglobin subunit delta 0.340566569 0.00702286 Q8N4C8 Misshapen-like kinase 1 0.33915893 0.00302351 Q4ZGM8 Hemoglobin alpha-2 globin mutant (Fragment) 0.253926844...”
• The effects of frozen tissue storage conditions on the integrity of RNA and protein.
  Auer, Biotechnic & histochemistry : official publication of the Biological Stain Commission 2014
  • “...32.26 P69905 hemoglobin alpha 15.23 10 70.4 48.8 36.32 11.3 30.0 90.49 139.3 105.0 28.06 Q3LR79 hemoglobin beta 11.46 10 60.6 54.9 9.82 176 31.0 55.14 69.6 51.9 29.27 P02042 hemoglobin subunit delta 16.03 12 64.3 46.3 32.39 10.1 20.0 66.13 110.2 106.3 3.58 P68871 LVV-hemorphin-7...”

LOC102938944 hemoglobin subunit beta-like from Chelonia mydas
48% identity, 29% coverage

• Species and population specific gene expression in blood transcriptomes of marine turtles
  Banerjee, BMC genomics 2021
  • “...green turtle ( Chelonia mydas) hemoglobin sequences available in the NCBI gene database (LOC102939173, LOC102945818, LOC102938944, LOC102946728, LOC102945589, NCBI, Accessed 28 April 2020) using bowtie2 (v. 2.3.4.3 [ 94 ]). Protein orthology between transcriptomes To enable estimation of the proportion of shared versus unique genes between...”

Q9BXA2 Beta-globin (Fragment) from Homo sapiens
48% identity, 71% coverage

• Proteomic analysis of decidua in patients with recurrent pregnancy loss (RPL) reveals mitochondrial oxidative stress dysfunction
  Yin, Clinical proteomics 2021
  • “...TRACH2012138, highly similar to Homo sapiens regulator of G-protein signalling 14 (RGS14), mRNA 0.476521157 0.00211812 Q9BXA2 Beta-globin (Fragment) 0.472636049 0.0112195 P69892 Hemoglobin subunit gamma-2 0.467543161 0.0169378 C8C504 Beta-globin 0.459856836 0.00578593 K7EP20 Dedicator of cytokinesis protein 6 (Fragment) 0.459262528 0.0211759 Q4TZM4 Hemoglobin beta chain (Fragment) 0.453442055 0.00422012...”

P10061 Hemoglobin subunit beta-2 from Sphenodon punctatus
45% identity, 29% coverage

• Gene Turnover and Diversification of the α- and β-Globin Gene Families in Sauropsid Vertebrates.
  Hoffmann, Genome biology and evolution 2018
  • “...amino acid sequences in order to include two tuatara -globin amino acid sequences, P10060 and P10061, as well protein records from testudines, squamates, and crocodilians that have no associated nucleotide sequence ( fig.4 ). The tree based on amino acid sequences was largely congruent with the...”
  • “...sequences, P10060, grouped with the squamate -globins, whereas the other two tuatara -globins, protein record P10061 and the one derived from the trascriptome, fell in the clade that includes the -globins of crocodilians, birds, and the T1 and T3 paralogs of testudines. Integrating the nucleotide and...”
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...Q28507 Q6H1U7 Q8GV40 Q9XSN2 P10060 P15165 P20854 P45719 P68015 P68228 P83273 Q28775 Q6IBF6 Q8GV41 Q9XSN3 P10061 P15166 P20855 P45720 P68016 P68229 P83478 Q28779 Q6LDH0 Q8GV42 Q9XTL1 P10062 P15448 P21197 P45721 P68017 P68230 P83479 Q28931 Q6LDH1 Q8HY34 Q9XTM2 P10777 P15449 P21198 P45722 P68018 P68231 P83611 Q28932 Q6QDC2...”

E9M263 Hemoglobin beta chain (Fragment) from Homo sapiens
48% identity, 74% coverage

• Tandem Mass Tag-Based Proteomic Analysis of Normal and Degenerated Human Intervertebral Discs
  Fu, Journal of pain research 2024
  • “...UV excision repair protein RAD23 homolog A OS=Homo sapiens OX=9606 GN=RAD23A PE=1 SV=1 RAD23A Decreased E9M263 Hemoglobin beta chain (Fragment) OS=Homo sapiens OX=9606 GN=HBB PE=3 SV=1 HBB Decreased A0A0G2JLB3 Glucosylceramidase OS=Homo sapiens OX=9606 GN=GBA PE=1 SV=1 GBA Decreased Q9NQ79 Cartilage acidic protein 1 OS=Homo sapiens OX=9606...”
• Low-Frequency Vibration Promotes Tumor Necrosis Factor-α Production to Increase Cartilage Degeneration in Knee Osteoarthritis.
  Yu, Cartilage 2021

P07406 Hemoglobin subunit beta from Passer montanus
48% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P02047 P02083 P02115 P02213 P07405 P08260 A2V8C0 O77655 P01948 P01981 P02011 P02048 P02084 P02116 P04237 P07406 P08261 A2V8C1 O81941 P01949 P01982 P02012 P02049 P02085 P02117 P04238 P07407 P08422 A2V8C2 O88752 P01950 P01983 P02013 P02050 P02086 P02118 P04239 P07408 P08423 A4GTS5 O88754 P01951 P01984 P02014 P02051 P02087...”

Q90864 Beta-H globin from Gallus gallus
48% identity, 29% coverage

• Plasma Proteome Alterations of Laying Hens Subjected to Heat Stress and Fed a Diet Supplemented with Pequi Oil (<i>Caryocar brasiliense Camb.</i>): New Insights in the Identification of Heat Stress Biomarkers
  da, Biomolecules 2024
  • “...APOV1 0.04 1 Q7LZ77 Apolipoprotein B-100 (Fragment) - 1 A0A8V1AAP1 Alpha-2-macroglobulin-like protein 1 A2ML4 1 Q90864 Beta-H globin - 1 1 Q90633 Complement C3 - 1 0.99 A6N9E0 Complement component 3d (Fragment) C3d 1 P14448 Fibrinogen alpha chain FGA 1 1 0.03 A0A8V0YX35 Fibrinogen beta chain...”

P18990 Hemoglobin subunit beta from Tursiops truncatus
45% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...Q0PB48 Q45XI6 Q7LZM6 Q9DF25 P11758 P18989 P24292 P62363 P68057 P80726 Q0PG38 Q45XI7 Q7LZM7 Q9FUD6 P11896 P18990 P24589 P62387 P68058 P80727 Q0WSU5 Q45XI8 Q7LZM8 Q9FVL0 P13273 P18993 P24659 P62741 P68059 P80945 Q0ZA50 Q45XI9 Q7M2Y4 Q9FY42 P13274 P18994 P24660 P62742 P68060 P80946 Q10732 Q45XJ0 Q7M2Y5 Q9GJS7 P13557 P18995...”

P24292 Hemoglobin subunit beta from Echinops telfairi
43% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...Q45XI5 Q7LZL6 Q9D0B2 P11757 P18988 P24291 P61948 P68056 P80271 Q0PB48 Q45XI6 Q7LZM6 Q9DF25 P11758 P18989 P24292 P62363 P68057 P80726 Q0PG38 Q45XI7 Q7LZM7 Q9FUD6 P11896 P18990 P24589 P62387 P68058 P80727 Q0WSU5 Q45XI8 Q7LZM8 Q9FVL0 P13273 P18993 P24659 P62741 P68059 P80945 Q0ZA50 Q45XI9 Q7M2Y4 Q9FY42 P13274 P18994 P24660...”
• Molecular evidence for multiple origins of Insectivora and for a new order of endemic African insectivore mammals
  Stanhope, Proceedings of the National Academy of Sciences of the United States of America 1998
  • “...P02091), guinea pig (P01947; P02095), tenrec (P24291; P24292), shrew (P01950; P02060), mole (P01951; P02061), and hedgehog (P01949; P02059). Combined amino acid...”

HBB2_BORSA / Q1AGS6 Hemoglobin subunit beta-2; Beta-2-globin; Hemoglobin beta-2 chain from Boreogadus saida (Polar cod) (Gadus saida) (see paper)
48% identity, 29% coverage

• function: Involved in oxygen transport from gills to the various peripheral tissues.
  subunit: Hb 3 is a heterotetramer of two alpha-2 and two beta-2 chains.
• Transcriptome of the Deep-Sea Black Scabbardfish, Aphanopus carbo (Perciformes: Trichiuridae): Tissue-Specific Expression Patterns and Candidate Genes Associated to Depth Adaptation
  Stefanni, International journal of genomics 2014
  • “...Gadiformes Gadidae Boreogadus saida Polar cod M + BR Polar 0400 Hb-A, Hb-B, COI DQ125471, Q1AGS6, KC015250 Table 7 Comparison of protein sequences of depth related genes between Aphanopus carbo database (All_gs454_xxx) and other fishes. Diff.: amino acid differences; Id. %: percentage of identity; Gaps: number...”
  • “...31 78.91 0 BT082849 Gasterosteus aculeatus 31 78.91 0 NM_1267638 Boreogadus saida 40 72.79 0 Q1AGS6 2 Notothenia angustata 42 71.43 0 P29628 2 Table 8 Statistics of EST-SSRs identified in Aphanopus carbo transcriptome. Searching item Numbers Total number of sequences examined 7,920 Total size of...”
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P19646 P29626 P63112 P68070 P82315 Q1AGS5 Q5GLZ6 Q7M422 Q9PVM2 P14390 P19759 P29628 P67815 P68071 P82316 Q1AGS6 Q5GLZ7 Q7T1B0 Q9PVM3 P14391 P19760 P30892 P67816 P68077 P82345 Q1AGS7 Q5I122 Q7Y079 Q9PVM4 P14392 P19789 P30893 P67817 P68078 P82990 Q1AGS8 Q5KSB7 Q7Y1Y1 Q9PVU6 P14520 P19831 P33499 P67818 P68079 P83114 Q1AGS9...”

P14524 Hemoglobin subunit beta from Turdus merula
48% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P07035 P08225 P0C0U8 10.1371/journal.pone.0009550.t003 Table 3 SwissProt/UniProt Accession Numbers for Hemoglobin dataset Part 2. P0C237 P14524 P20018 P41327 P67822 P68194 P83132 Q27940 Q6AW44 Q8AXX7 Q9TSN9 P0C238 P14525 P20019 P41328 P67823 P68222 P83133 Q28220 Q6AW45 Q8AYL9 Q9TVA3 P0C239 P14526 P20243 P41329 P67824 P68223 P83134 Q28221 Q6B0K9 Q8AYM0...”

P18435 Hemoglobin subunit epsilon from Carlito syrichta
48% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P83623 Q2MHE0 Q6WN20 Q90ZM4 P10783 P17689 P21380 P51443 P68023 P68237 P83624 Q2PAD4 Q6WN21 Q91473 P10784 P18435 P21667 P51465 P68024 P68238 P83625 Q3C1F3 Q6WN22 Q941P9 P10785 P18436 P21668 P55267 P68025 P68239 P84203 Q3C1F4 Q6WN25 Q941Q1 P10786 P18707 P21766 P56250 P68026 P68240 P84204 Q3MQ26 Q6WN26 Q946U7 P10883 P18969...”

O13077 Hemoglobin subunit beta from Gadus morhua
48% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P02136 P06638 P07433 P09907 O12985 P01938 P01969 P02001 P02033 P02073 P02106 P02137 P06639 P07803 P09908 O13077 P01939 P01971 P02002 P02035 P02074 P02107 P02138 P06642 P08054 P09909 O13078 P01940 P01972 P02003 P02036 P02075 P02108 P02139 P06643 P08223 P0C0U6 O13163 P01941 P01973 P02004 P02038 P02076 P02109 P02140 P07034...”

NP_990820 hemoglobin subunit beta from Gallus gallus
P02112 Hemoglobin subunit beta from Gallus gallus
48% identity, 29% coverage

• Chicken β-globin insulators fail to shield the nkx2.5 promoter from integration site effects in zebrafish.
  Grajevskaja, Molecular genetics and genomics : MGG 2013
  • GeneRIF: Flanking a transgenic construct by chicken HS4 insulation sequences from beta globin leads to overall increase in the expression of nkx2.5:mRFP.
• Histone crosstalk directed by H2B ubiquitination is required for chromatin boundary integrity.
  Ma, PLoS genetics 2011
  • GeneRIF: Data show that loss of boundary function leads to the sequential spreading of H3K9me2, H3K9me3, and H4K20me3 over the entire 50 kb FOLR1 and beta-globin region and silencing of FOLR1 expression.
• BetaA, the major beta globin in definitive red blood cells, is present from the onset of primitive erythropoiesis in chicken.
  Alev, Developmental dynamics : an official publication of the American Association of Anatomists 2008 (PubMed)
  • GeneRIF: Data suggest that betaA locus is active from the onset of primitive erythropoiesis and that beta globin switching during development may reflect a change in relative transcript abundance rather than a strict on/off switch in gene activation.
• Chicken beta-globin insulator overcomes variegation of transgenes in Xenopus embryos.
  Sekkali, FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008 (PubMed)
  • GeneRIF: The Beta-globuin insulator confers copy-number-dependent transgene expression and can increase transgene expression from weak regulatory elements
• Enhancer blocking by chicken beta-globin 5'-HS4: role of enhancer strength and insulator nucleosome depletion.
  Zhao, The Journal of biological chemistry 2006 (PubMed)
  • GeneRIF: a domain of active chromatin is formed by spreading from a beta-globin enhancer to a target gene and can be blocked by a nucleosome-free gap in an insulato
• Targeted deletion of the chicken beta-globin regulatory elements reveals a cooperative gene silencing activity.
  Wang, The Journal of biological chemistry 2005 (PubMed)
  • GeneRIF: regulatory elements of chicken beta-globin function as part of a common silencing pathway
• The 5'-HS4 chicken beta-globin insulator is a CTCF-dependent nuclear matrix-associated element.
  Yusufzai, Proceedings of the National Academy of Sciences of the United States of America 2004
  • GeneRIF: a DNA sequence element, HS4, at the 5' end of the beta-globin locus, contains a binding site for CTCF that is necessary and sufficient for insulator action
• Plasma Proteome Alterations of Laying Hens Subjected to Heat Stress and Fed a Diet Supplemented with Pequi Oil (<i>Caryocar brasiliense Camb.</i>): New Insights in the Identification of Heat Stress Biomarkers
  da, Biomolecules 2024
  • “...subunit epsilon 1 HBBA 1 1 1 P02128 Hemoglobin subunit epsilon HBE 0.97 0.03 0.98 P02112 Hemoglobin subunit beta HBB 0.98 0.99 P02127 Hemoglobin subunit rho - 0.98 A0A8V0X997 Hemopexin - 1 1 P01875 Ig mu chain C region - 1 0.98 A0A8V0XLK0 Ig-like domain-containing protein...”
• Metalloproteomic analysis of liver proteins isolated from broilers fed with different sources and levels of copper and manganese
  Aparecida, Scientific reports 2024
  • “...P01994 HBAA Hemoglobin subunit alpha-A 8.54/15,428.87 5828.38 P80226 FABP1 Fatty acid-binding protein. liver 8.67/14,210.37 1769.519 P02112 HBB Hemoglobin subunit beta 8.84/16,466.13 820.2869 P02127 N/A Hemoglobin subunit rho 8.78/16,589.21 281.6852 P02128 HBE Hemoglobin subunit psilon 9.07/16,603.23 281.6852 P00337 LDHB L-lactate dehydrogenase B chain 7.07/36,318.09 263.6445 P02001 HBAD...”
  • “...Cu/Mn (OH)Cl=Cu P00356 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 8.70/35,703.97 2980.18 P80566 SOD1 Superoxide dismutase [CuZn] 6.1/15,703.6 1844.127 P02112 HBB Hemoglobin subunit beta 8.84/16,466.13 890.2412 P07341 ALDOB Fructose-bisphosphate aldolase B 8.81/39,295.78 570.7814 P02128 HBE Hemoglobin subunit epsilon 9.07/16,603.23 208.8738 P02127 N/A Hemoglobin subunit rho 8.78/16,589.21 175.0719 P80226 FABP1 Fatty...”
• Proteolysis and changes in meat quality of chicken pectoralis major and iliotibialis muscles in relation to muscle fiber type distribution
  Cheng, Poultry science 2022
  • “...nd nd 3 1 A0A1L1RNL6 NAC-A/B domain-containing protein Transcription regulation 368 16 14 9 14 P02112 Hemoglobin subunit beta Cytosol, oxygen binding 19 nd nd 1 1 F1N9H4 Elongation factor 1-alpha Biosynthetic process 183 5 25 6 33 P00940 Triosephosphate isomerase Cytosol, glycolysis / gluconeogenesis, metabolic...”
• Hepatotoxic mechanism of diclofenac sodium on broiler chicken revealed by iTRAQ-based proteomics analysis.
  Sun, Journal of veterinary science 2022
  • “...CYP3A5 +2.23 0.001035142 P02001 Hemoglobin subunit alpha-D HBAD +2.18 0.020137242 Q6QLQ9 Gallinacin-10 GAL10 +2.16 0.003828247 P02112 Hemoglobin subunit beta HBB +2.12 0.020606299 P01994 Hemoglobin subunit alpha-A HBAA; +2.07 0.031988951 F1NK40 Uncharacterized protein A2ML4 +1.97 0.00055847 Q6QLR3 Gallinacin-6 GAL6 +1.88 0.039627803 A0A1D5PHX5 ER lumen protein-retaining receptor KDELR3...”
• A Placenta Derived C-Terminal Fragment of β-Hemoglobin With Combined Antibacterial and Antiviral Activity
  Groß, Frontiers in microbiology 2020
  • “...Chelonoidis carbonarius (Red-footed tortoise) Q98905 ; Meleagris gallopavo (Common turkey) P81023 ; Gallus gallus (Chicken) P02112 ; Danio rerio (Zebrafish) Q90486 ; Protein sequences were aligned using Clustal W 3 and residue conservation was determined using the Scorecons Server 4 . Shannons information theoretical entropy was...”
• A novel MALDI-TOF MS-based method for blood meal identification in insect vectors: A proof of concept study on phlebotomine sand flies
  Hlavackova, PLoS neglected tropical diseases 2019
  • “...FFEHFGDLSSADAVMNNAK 2099.95 Dog P60524 VNVDEVGGEALGR 1314.66 FFDSFGDLSTPDAVMSNAK 2048.93 Cat P07412 VNVDEVGGEALGR 1314.66 FFESFGDLSSADAIMSNAK 2036.93 Chicken P02112 VNVAECGAEALAR 1302.65 FFASFGNLSSPTAILGNPMVR 2226.14 The sequences and masses of hemoglobin peptides were generated using a PeptideMass tool [ 27 ]. Two peptide sequences from each hemoglobin subunit are shown for...”
• Host intestinal biomarker identification in a gut leakage model in broilers.
  De, Veterinary research 2019
  • “...A5 ANXA5 0.0266 Challenge P08250 Apolipoprotein A-1 APOA1 0.0277 Challenge P11722 Fibronectin FINC 0.0106 Challenge P02112 Hemoglobin subunit beta HBB 0.0158 Challenge P08940 Myeloid protein 1 MIM1 0.0008 Challenge P16039 Nucleophosmin NPM 0.0071 Challenge P10184 Ovoinhibitor IOV7 0.0254 Challenge P80566 Superoxide dismutase [CuZn] SOD 0.0287 Control...”
• Compressed collagen and decellularized tissue - novel components in a pipeline approach for the study of cancer metastasis
  Keeton, BMC cancer 2018
  • “...3 1.94 2 P01012 Ovalbumin OS=Gallus gallus GN=SERPINB14 PE=1 SV=2 - [OVAL_CHICK] 6 18.39 2 P02112 Hemoglobin subunit beta OS=Gallus gallus GN=HBB PE=1 SV=2 - [HBB_CHICK] 2 21.09 2 P00698 Lysozyme C OS=Gallus gallus GN=LYZ PE=1 SV=1 - [LYSC_CHICK] 3 33.33 2 O93532 Keratin, type II...”
  • “...6.12 1 P11722 Fibronectin (Fragments) OS=Gallus gallus GN=FN1 PE=2 SV=3 - [FINC_CHICK] 2 3.5 1 P02112 Hemoglobin subunit beta OS=Gallus gallus GN=HBB PE=1 SV=2 - [HBB_CHICK] 2 21.09 1 P02467 Collagen alpha-2(I) chain (Fragments) OS=Gallus gallus GN=COL1A2 PE=1 SV=2 - [CO1A2_CHICK] 2 1.62 2 P02112 Hemoglobin...”
• More

P68016 Hemoglobin subunit epsilon from Aotus azarae
P68017 Hemoglobin subunit epsilon from Alouatta belzebul
P68018 Hemoglobin subunit epsilon from Alouatta seniculus
P68019 Hemoglobin subunit epsilon from Ateles geoffroyi
P68020 Hemoglobin subunit epsilon from Brachyteles arachnoides
P68021 Hemoglobin subunit epsilon from Cacajao calvus
P68022 Hemoglobin subunit epsilon from Plecturocebus moloch
P68023 Hemoglobin subunit epsilon from Cheracebus torquatus
P68024 Hemoglobin subunit epsilon from Callimico goeldii
P68025 Hemoglobin subunit epsilon from Chiropotes satanas
48% identity, 29% coverage

• Bioinformatics-based Characterization of the Sequence Variability of Zika Virus Polyprotein and Envelope Protein (E).
  Polanco, Evolutionary bioinformatics online 2022
  • “...A6U4Y6, A7X6Y6, A7TMJ6, P19833, Q9GZU1, P44961, Q99K10, B1JM25, P68022, P68025, P68023, P68024, P68021, P68020, P68019, P68016, P68018, P68017, Q632I5, P54886, F5HIN9, P16728, A8G7P8, and G3V8Y7. CAM-P (It is the same protein group as POL-P Protein). Q32-P Q32ZE1, Q5QQX7, B0U1Q8, P13088, P13088, Q7VLI5, P9WJF4, P9WJF5, P57873, Q2RMS0,...”
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P10060 P15165 P20854 P45719 P68015 P68228 P83273 Q28775 Q6IBF6 Q8GV41 Q9XSN3 P10061 P15166 P20855 P45720 P68016 P68229 P83478 Q28779 Q6LDH0 Q8GV42 Q9XTL1 P10062 P15448 P21197 P45721 P68017 P68230 P83479 Q28931 Q6LDH1 Q8HY34 Q9XTM2 P10777 P15449 P21198 P45722 P68018 P68231 P83611 Q28932 Q6QDC2 Q8QG65 Q9Y0D5 P10778 P15469...”
• Bioinformatics-based Characterization of the Sequence Variability of Zika Virus Polyprotein and Envelope Protein (E).
  Polanco, Evolutionary bioinformatics online 2022
  • “...A7TMJ6, P19833, Q9GZU1, P44961, Q99K10, B1JM25, P68022, P68025, P68023, P68024, P68021, P68020, P68019, P68016, P68018, P68017, Q632I5, P54886, F5HIN9, P16728, A8G7P8, and G3V8Y7. CAM-P (It is the same protein group as POL-P Protein). Q32-P Q32ZE1, Q5QQX7, B0U1Q8, P13088, P13088, Q7VLI5, P9WJF4, P9WJF5, P57873, Q2RMS0, P93004, and...”
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P10061 P15166 P20855 P45720 P68016 P68229 P83478 Q28779 Q6LDH0 Q8GV42 Q9XTL1 P10062 P15448 P21197 P45721 P68017 P68230 P83479 Q28931 Q6LDH1 Q8HY34 Q9XTM2 P10777 P15449 P21198 P45722 P68018 P68231 P83611 Q28932 Q6QDC2 Q8QG65 Q9Y0D5 P10778 P15469 P21199 P51438 P68019 P68232 P83612 Q29415 Q6R7N2 Q90485 Q9Y0E6 P10780 P16309...”
• Bioinformatics-based Characterization of the Sequence Variability of Zika Virus Polyprotein and Envelope Protein (E).
  Polanco, Evolutionary bioinformatics online 2022
  • “...A7X6Y6, A7TMJ6, P19833, Q9GZU1, P44961, Q99K10, B1JM25, P68022, P68025, P68023, P68024, P68021, P68020, P68019, P68016, P68018, P68017, Q632I5, P54886, F5HIN9, P16728, A8G7P8, and G3V8Y7. CAM-P (It is the same protein group as POL-P Protein). Q32-P Q32ZE1, Q5QQX7, B0U1Q8, P13088, P13088, Q7VLI5, P9WJF4, P9WJF5, P57873, Q2RMS0, P93004,...”
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P10062 P15448 P21197 P45721 P68017 P68230 P83479 Q28931 Q6LDH1 Q8HY34 Q9XTM2 P10777 P15449 P21198 P45722 P68018 P68231 P83611 Q28932 Q6QDC2 Q8QG65 Q9Y0D5 P10778 P15469 P21199 P51438 P68019 P68232 P83612 Q29415 Q6R7N2 Q90485 Q9Y0E6 P10780 P16309 P21200 P51440 P68020 P68234 P83613 Q2KPA3 Q6S9E2 Q90486 Q9YGW1 P10781 P16417...”
• Bioinformatics-based Characterization of the Sequence Variability of Zika Virus Polyprotein and Envelope Protein (E).
  Polanco, Evolutionary bioinformatics online 2022
  • “...A5IW31, A6U4Y6, A7X6Y6, A7TMJ6, P19833, Q9GZU1, P44961, Q99K10, B1JM25, P68022, P68025, P68023, P68024, P68021, P68020, P68019, P68016, P68018, P68017, Q632I5, P54886, F5HIN9, P16728, A8G7P8, and G3V8Y7. CAM-P (It is the same protein group as POL-P Protein). Q32-P Q32ZE1, Q5QQX7, B0U1Q8, P13088, P13088, Q7VLI5, P9WJF4, P9WJF5, P57873,...”
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P10777 P15449 P21198 P45722 P68018 P68231 P83611 Q28932 Q6QDC2 Q8QG65 Q9Y0D5 P10778 P15469 P21199 P51438 P68019 P68232 P83612 Q29415 Q6R7N2 Q90485 Q9Y0E6 P10780 P16309 P21200 P51440 P68020 P68234 P83613 Q2KPA3 Q6S9E2 Q90486 Q9YGW1 P10781 P16417 P21201 P51441 P68021 P68235 P83614 Q2KPA4 Q6T497 Q90487 Q9YGW2 P10782 P16418...”
• Bioinformatics-based Characterization of the Sequence Variability of Zika Virus Polyprotein and Envelope Protein (E).
  Polanco, Evolutionary bioinformatics online 2022
  • “...P67472, A5IW31, A6U4Y6, A7X6Y6, A7TMJ6, P19833, Q9GZU1, P44961, Q99K10, B1JM25, P68022, P68025, P68023, P68024, P68021, P68020, P68019, P68016, P68018, P68017, Q632I5, P54886, F5HIN9, P16728, A8G7P8, and G3V8Y7. CAM-P (It is the same protein group as POL-P Protein). Q32-P Q32ZE1, Q5QQX7, B0U1Q8, P13088, P13088, Q7VLI5, P9WJF4, P9WJF5,...”
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P10778 P15469 P21199 P51438 P68019 P68232 P83612 Q29415 Q6R7N2 Q90485 Q9Y0E6 P10780 P16309 P21200 P51440 P68020 P68234 P83613 Q2KPA3 Q6S9E2 Q90486 Q9YGW1 P10781 P16417 P21201 P51441 P68021 P68235 P83614 Q2KPA4 Q6T497 Q90487 Q9YGW2 P10782 P16418 P21379 P51442 P68022 P68236 P83623 Q2MHE0 Q6WN20 Q90ZM4 P10783 P17689 P21380...”
• Bioinformatics-based Characterization of the Sequence Variability of Zika Virus Polyprotein and Envelope Protein (E).
  Polanco, Evolutionary bioinformatics online 2022
  • “...P99117, P67472, A5IW31, A6U4Y6, A7X6Y6, A7TMJ6, P19833, Q9GZU1, P44961, Q99K10, B1JM25, P68022, P68025, P68023, P68024, P68021, P68020, P68019, P68016, P68018, P68017, Q632I5, P54886, F5HIN9, P16728, A8G7P8, and G3V8Y7. CAM-P (It is the same protein group as POL-P Protein). Q32-P Q32ZE1, Q5QQX7, B0U1Q8, P13088, P13088, Q7VLI5, P9WJF4,...”
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P10780 P16309 P21200 P51440 P68020 P68234 P83613 Q2KPA3 Q6S9E2 Q90486 Q9YGW1 P10781 P16417 P21201 P51441 P68021 P68235 P83614 Q2KPA4 Q6T497 Q90487 Q9YGW2 P10782 P16418 P21379 P51442 P68022 P68236 P83623 Q2MHE0 Q6WN20 Q90ZM4 P10783 P17689 P21380 P51443 P68023 P68237 P83624 Q2PAD4 Q6WN21 Q91473 P10784 P18435 P21667 P51465...”
• Bioinformatics-based Characterization of the Sequence Variability of Zika Virus Polyprotein and Envelope Protein (E).
  Polanco, Evolutionary bioinformatics online 2022
  • “...Q29003, Q6G2QB, P05490, Q11QT1, P99117, P67472, A5IW31, A6U4Y6, A7X6Y6, A7TMJ6, P19833, Q9GZU1, P44961, Q99K10, B1JM25, P68022, P68025, P68023, P68024, P68021, P68020, P68019, P68016, P68018, P68017, Q632I5, P54886, F5HIN9, P16728, A8G7P8, and G3V8Y7. CAM-P (It is the same protein group as POL-P Protein). Q32-P Q32ZE1, Q5QQX7, B0U1Q8,...”
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P10781 P16417 P21201 P51441 P68021 P68235 P83614 Q2KPA4 Q6T497 Q90487 Q9YGW2 P10782 P16418 P21379 P51442 P68022 P68236 P83623 Q2MHE0 Q6WN20 Q90ZM4 P10783 P17689 P21380 P51443 P68023 P68237 P83624 Q2PAD4 Q6WN21 Q91473 P10784 P18435 P21667 P51465 P68024 P68238 P83625 Q3C1F3 Q6WN22 Q941P9 P10785 P18436 P21668 P55267 P68025...”
• Bioinformatics-based Characterization of the Sequence Variability of Zika Virus Polyprotein and Envelope Protein (E).
  Polanco, Evolutionary bioinformatics online 2022
  • “...P05490, Q11QT1, P99117, P67472, A5IW31, A6U4Y6, A7X6Y6, A7TMJ6, P19833, Q9GZU1, P44961, Q99K10, B1JM25, P68022, P68025, P68023, P68024, P68021, P68020, P68019, P68016, P68018, P68017, Q632I5, P54886, F5HIN9, P16728, A8G7P8, and G3V8Y7. CAM-P (It is the same protein group as POL-P Protein). Q32-P Q32ZE1, Q5QQX7, B0U1Q8, P13088, P13088,...”
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...Q9YGW2 P10782 P16418 P21379 P51442 P68022 P68236 P83623 Q2MHE0 Q6WN20 Q90ZM4 P10783 P17689 P21380 P51443 P68023 P68237 P83624 Q2PAD4 Q6WN21 Q91473 P10784 P18435 P21667 P51465 P68024 P68238 P83625 Q3C1F3 Q6WN22 Q941P9 P10785 P18436 P21668 P55267 P68025 P68239 P84203 Q3C1F4 Q6WN25 Q941Q1 P10786 P18707 P21766 P56250 P68026...”
• Bioinformatics-based Characterization of the Sequence Variability of Zika Virus Polyprotein and Envelope Protein (E).
  Polanco, Evolutionary bioinformatics online 2022
  • “...Q11QT1, P99117, P67472, A5IW31, A6U4Y6, A7X6Y6, A7TMJ6, P19833, Q9GZU1, P44961, Q99K10, B1JM25, P68022, P68025, P68023, P68024, P68021, P68020, P68019, P68016, P68018, P68017, Q632I5, P54886, F5HIN9, P16728, A8G7P8, and G3V8Y7. CAM-P (It is the same protein group as POL-P Protein). Q32-P Q32ZE1, Q5QQX7, B0U1Q8, P13088, P13088, Q7VLI5,...”
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...Q90ZM4 P10783 P17689 P21380 P51443 P68023 P68237 P83624 Q2PAD4 Q6WN21 Q91473 P10784 P18435 P21667 P51465 P68024 P68238 P83625 Q3C1F3 Q6WN22 Q941P9 P10785 P18436 P21668 P55267 P68025 P68239 P84203 Q3C1F4 Q6WN25 Q941Q1 P10786 P18707 P21766 P56250 P68026 P68240 P84204 Q3MQ26 Q6WN26 Q946U7 P10883 P18969 P21767 P56251 P68027...”
• Bioinformatics-based Characterization of the Sequence Variability of Zika Virus Polyprotein and Envelope Protein (E).
  Polanco, Evolutionary bioinformatics online 2022
  • “...Q6G2QB, P05490, Q11QT1, P99117, P67472, A5IW31, A6U4Y6, A7X6Y6, A7TMJ6, P19833, Q9GZU1, P44961, Q99K10, B1JM25, P68022, P68025, P68023, P68024, P68021, P68020, P68019, P68016, P68018, P68017, Q632I5, P54886, F5HIN9, P16728, A8G7P8, and G3V8Y7. CAM-P (It is the same protein group as POL-P Protein). Q32-P Q32ZE1, Q5QQX7, B0U1Q8, P13088,...”
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...Q91473 P10784 P18435 P21667 P51465 P68024 P68238 P83625 Q3C1F3 Q6WN22 Q941P9 P10785 P18436 P21668 P55267 P68025 P68239 P84203 Q3C1F4 Q6WN25 Q941Q1 P10786 P18707 P21766 P56250 P68026 P68240 P84204 Q3MQ26 Q6WN26 Q946U7 P10883 P18969 P21767 P56251 P68027 P68256 P84205 Q3S3T0 Q6WN27 Q947C5 P10885 P18970 P21768 P56285 P68028...”

Q63011 Zero beta-globin (Fragment) from Rattus norvegicus
48% identity, 29% coverage

• ITRAQ Based Proteomics Reveals the Potential Mechanism of Placental Injury Induced by Prenatal Stress.
  Li, International journal of molecular sciences 2024
  • “...subunit, non-ATPase, 3 (Psmd3) Q3B8P5 Psmd8 protein (Fragment) (Psmd8) P83868 Prostaglandin E synthase 3 (Ptges3) Q63011 Zero beta-globin (Fragment) (Q63011) P62494 Ras-related protein Rab-11A (Rab11a) P62828 GTP-binding nuclear protein Ran (Ran) D4A2G9 Protein Ranbp1 (Ranbp1) Q71UF4 Histone-binding protein RBBP7 (Rbbp7) B2RZA9 Ube2l3 protein (rCG_36772) G3V7V6 All-trans-13,14-dihydroretinol...”
• Analysis of Therapeutic Targets of A Novel Peptide Athycaltide-1 in the Treatment of Isoproterenol-Induced Pathological Myocardial Hypertrophy.
  Zheng, Cardiovascular therapeutics 2022
  • “...beta-2 8.65 E -122 2.38 E -17 A0A0G2JSV6 Hba2 Globin c2 0 7.57 E -69 Q63011 Zero beta-globin (fragment) 6.73 E -77 5.41 E -08 A0A0G2JV08 Suz12 Suppressor of zeste 12 homolog (Drosophila) 3.59 10 2 4.14 10 2 F1LZH0 ENSRNOG00000049299 Ig kappa chain V19-17-like 5.08...”
• An Integrated Multi-Omic Network Analysis Identifies Seizure-Associated Dysregulated Pathways in the GAERS Model of Absence Epilepsy.
  Harutyunyan, International journal of molecular sciences 2022
  • “...10 13 G3V6T7 PDIA4 Protein disulfide isomerase family A, member 4 4.98460727 5.74 10 12 Q63011 NA (fragment) Zero beta-globin 3.4885391 3.25 10 10 CAMKV CAMKV CaM kinase-like vesicle-associated 5.5727073 3.67 10 9 A0A0G2JSW3 HBB Haemoglobin subunit beta 8.40519465 3.75 10 9 NIT2 NIT2 Nitrilase family,...”
• Bioinformatics analysis of differentially expressed proteins in alcoholic fatty liver disease treated with recombinant human cytoglobin
  Zhang, Molecular medicine reports 2021
  • “...7.04 87.7 Within the 20S core complex, PSMB5 displays a chymotrypsin-like activity. 49 Zero beta-globin Q63011 15953.20 7.35 286 Involved in oxygen transport from the lung to the various peripheral tissues. 10 Complement C4 P08649 C4 193638.91 7.34 68.7 It induces the contraction of smooth muscle,...”
• Laser microdissection-based microproteomics of the hippocampus of a rat epilepsy model reveals regional differences in protein abundances.
  do, Scientific reports 2020
  • “...GL-dDG/GL-vDG Proteasome subunit alpha type-2 P17220 Psma2 GL-dDG Ptges3 protein B2GV92 Ptges3 GL-vDG Zero beta-globin Q63011 Q63011 ML-dDG/GL-vDG RAN-binding protein 3 M0R5Q3 Ranbp3 GL-dDG/GL-vDG RCG48018 Q6AYA7 Rfk GL-dDG 40S ribosomal protein S8 B2RYR8 Rps8 GL-vDG RuvB-like 1 P60123 Ruvbl1 GL-dDG/GL-vDG SAP domain-containing ribonucleoprotein Q498U4 Sarnp GL-dDG...”
• Comparative proteomic analysis of the brain and colon in three rat models of irritable bowel syndrome.
  Zhang, Proteome science 2020
  • “...CB Microtubule-associated protein F1LQB5 unknown CB Anamorsin Q5XID1 / apoptotic process CB Zero beta-globin (Fragment) Q63011 heme binding; iron ion binding; oxygen binding; oxygen transporter activity CB LSM4 homolog, U6 small nuclear RNA associated ( S. cerevisiae ) (Predicted), isoform CRA_a NADH dehydrogenase D4A2C6 unknown CB...”
• Proteomic changes of CD4+/CD25+/forkhead box p3+ regulatory T cells in a 30-day rat model of sepsis survival.
  Jiao, Experimental and therapeutic medicine 2017
• Large-Scale, Ion-Current-Based Proteomic Investigation of the Rat Striatal Proteome in a Model of Short- and Long-Term Cocaine Withdrawal
  Shen, Journal of proteome research 2016
  • “...0.785 0.1 <0.001 0.914 0.1 >0.05 P31977 Ezrin 0.678 0.1 <0.001 0.870 0.1 >0.05 RBC/Plasma Q63011 Zero beta globin 0.688 0.09 <0.001 P02091 Hemoglobin subunit beta-1 1.64 0.09 <0.001 0.700 0.07 <0.001 P11517 Hemoglobin subunit beta-2 1.28 0.1 <0.001 0.722 0.09 <0.001 P01946 Hemoglobin subunit alpha-1/2...”
• More

Q6PDU6 Beta-glo from Rattus norvegicus
48% identity, 29% coverage

• Differential Responses of Retinal Neurons and Glia Revealed via Proteomic Analysis on Primary and Secondary Retinal Ganglion Cell Degeneration
  Kwong, International journal of molecular sciences 2023
  • “...Glial fibrillary acidic protein 1.57 0.65 0.87 0.03 A0A0G2JSH5 Alb Albumin 1.57 0.65 0.82 0.02 Q6PDU6 Hbb-b1 Beta-glo 1.50 0.59 0.82 0.03 K7S2S2 Hist2h2aa3 Histone H2A 1.43 0.52 0.79 0.01 Downregulation Q6P3E1 Rps16 Rps16 protein 0.74 0.43 0.70 0.03 D3ZK97 H3f3c Histone H3 0.74 0.43 0.99...”
  • “...Alpha-1-antiproteinase 1.78 0.83 0.82 0.01 A0A0G2K376 Fip1l1 Pre-mRNA 3-end-processing factor FIP1 1.75 0.80 0.70 0.01 Q6PDU6 Hbb-b1 Beta-glo 1.70 0.77 0.80 0.04 A0A1K0FUA6 LOC100134871 Globin a2 1.69 0.76 0.83 0.03 P14046 A1i3 Alpha-1-inhibitor 3 1.68 0.75 0.84 0.01 P20059 Hpx Hemopexin 1.66 0.73 0.85 0.03 Q923W4...”
• Biological Effects of Korean Red Ginseng Polysaccharides in Aged Rat Using Global Proteomic Approach.
  Lee, Molecules (Basel, Switzerland) 2020
  • “...0.00005 Alpha-2-macroglobulin A2m P06238 7.7 0.00000 Spectrin beta chain Sptbn1 G3V6S0 14.7 0.00009 Beta-glo Hbb-b1 Q6PDU6 6.8 0.00000 Sialic acid-binding Ig-like lectin 1 Siglec1 A0A0G2K320 11.8 0.00016 Spectrin beta chain Sptb A0A140UHX6 6.3 0.00000 DnaJ heat shock protein family (Hsp40) member C13 Dnajc13 D3ZN27 9.8 0.00016...”
• Chronic morphine alters the presynaptic protein profile: identification of novel molecular targets using proteomics and network analysis.
  Abul-Husn, PloS one 2011
  • “...c oxidase subunit Vb P12075 Kinase CDC42BPA Serine/threonine-protein kinase MRCK alpha O54874 Other HBB Beta-globin Q6PDU6 Proteins with morphine/saline ratios of at least 0.5 standard deviations from the mean and that showed consistent changes in at least 2 of the experiments were selected. The numbers in...”
• Proteomic and phosphoproteomic analyses of the soluble fraction following acute spinal cord contusion in rats.
  Chen, Journal of neurotrauma 2010

Q62669 Globin a1 from Rattus norvegicus
48% identity, 29% coverage

• Proteomic analysis of spinal dorsal horn in prior exercise protection against neuropathic pain.
  Chen, Scientific reports 2025
  • “...group. A total of 13 overlapping DEPs (protein accession: B1H216, B0BNN3, O55158, D4A9D6, P17475, Q63910, Q62669, P06866, A0A0G2JU, P06399, P02091, P02680 and P02770) were upregulated after CCI and downregulated in prior exercise (Fig. 2 C and Table 1 ). Table 1 shows the information of the...”
  • “...P17475 Alpha-1-antiproteinase Serpina1 206.69 1.64E-08 0.0031391 1.05E-08 Q63910 Globin c1 Hba-a2 89.312 3.86E-09 0.11579 0.00263 Q62669 Globin a1 Hbb-b1 8.9919 0.00090 0.4045 0.04458 P06866 Haptoglobin Hp 22.668 0.04153 0.0288 0.04132 A0A0G2JUP5 Murinoglobulin 1 Mug1 61.406 0.04075 0.01059 0.04066 P06399 Fibrinogen alpha chain Fga 277.31 5.63E-08 0.19437...”
• Seminal plasma S100A8/A9 as a potential biomarker of genital tract inflammation
  Shen, Asian journal of andrology 2024
  • “...0.324 Down 0.000122973 Oxct2a Q5XIV1 Phosphoglycerate kinase OS=Rattus norvegicus OX=10116 GN=Pgk2 0.603 Down 2.0269E-06 Pgk2 Q62669 Beta-globin OS=Rattus norvegicus OX=10116 GN=LOC103694855 0.272 Down 0.02194 LOC103694855 Q62803 Hyaluronidase PH-20 OS=Rattus norvegicus OX=10116 GN=Spam1 0.345 Down 0.00033742 Spam1 Q62867 Gamma-glutamyl hydrolase OS=Rattus norvegicus OX=10116 GN=Ggh 1.635 Up 0.00018258...”
• Differential renal proteomics analysis in a novel rat model of iodinated contrast-induced acute kidney injury.
  Deng, Renal failure 2023
  • “...Description Gene Average Fold Change (CI-AKI/Control) p -Value P01946 Hemoglobin subunit alpha-1/2 Hba1 7.652 <0.01 Q62669 Globin a1 LOC103694855 5.872 <0.01 O88752 Epsilon 1 globin Hbe1 5.71 <0.01 A0A0G2JSV6 Globin c2 Hba-a2 5.557 <0.01 D4A7N7 Tetratricopeptide repeat domain 39D Ttc39d 5.263 <0.01 P01048 T-kininogen 1 Map1...”
• Hyperbaric Oxygen Therapy-Induced Molecular and Pathway Changes in a Rat Model of Spinal Cord Injury: A Proteomic Analysis.
  Li, Dose-response : a publication of International Hormesis Society 2022
  • “...D4A9D6 1.33 Up ERMN 1.21 Up D3ZVB7 1.41 Up HBB2 1.43 Up LEG5 1.49 Up Q62669 1.49 Up HBA 1.59 Up Figure 2. Identification and quantitation of differentially expressed proteins by mass spectrometry trials between SCI groups and SCI + HBOT group on POD 7, 14,...”
  • “...exchanger), member 1, B3AT), Hba1 (Hemoglobin subunit alpha- 1/2, HBA), and Hbb-b1 (Hemoglobin subunit beta-2-like, Q62669), are related to erythrocyte. Figure 5. IPA biological pathway analysis for differentially expressed proteins (DEPs). The signaling pathways where proteins with differential SCI + HBOT vs SCI changes as well...”
• Long-term evaluation of safety and biological effects of Korean Red Ginseng (Panax Ginseng): a long-term in vivo study.
  Park, BMC complementary medicine and therapies 2022
  • “...0.012 Cysteine- and glycine-rich protein 1 P47875 CSRP1 Nucleus other -0.984 0.022 Haemoglobin subunit beta-2-like Q62669 LOC103694855 Other other -1.014 0.020 Glutathione peroxidase 3 A0A0G2K531 GPX3 ES enzyme -1.02 0.022 Thioredoxin R4GNK3 TXN Cytoplasm enzyme -1.034 0.003 Ig-like domain-containing protein F1LWD0 -1.072 0.001 Pleckstrin A0A0G2K393 PLEK...”
• iTRAQ-based proteomic profiling reveals protein alterations after traumatic brain injury and supports thyroxine as a potential treatment
  Zhang, Molecular brain 2021
  • “...30 70.8 129.2 <0.0001 1.83 P02770 Serum albumin (Alb) 64 68.7 69.9 130.2 <0.0001 1.86 Q62669 Globin a1 (LOC103694855) 46 16 68.8 131.2 <0.0001 1.91 B0BNN3 Carbonic anhydrase 1 (Ca1) 8 28.3 67.7 132.3 0.00010 1.95 M0RCX0 Pterin-4 alpha-carbinolamine dehydratase 2 (Pcbd2) 22 14.1 66.4 133.6...”
  • “...25,108,376.28 2.17 <0.0001 P42930 Hspb1 5,132,833.438 18,194,532.5 3.54 <0.0001 Q03626 Mug1 70,921,905.59 149,480,671.3 2.11 <0.0001 Q62669 LOC103694855 487,524,419.4 1,385,746,698 2.84 <0.0001 Q63041 A1m 9,261,727.438 18,843,111.94 2.03 <0.0001 Q6IFU7 Krt42 40,789,820 35,523,088.63 0.87 0.31 Q6IFV1 Krt14 927,194,854 778,350,430.6 0.84 0.00030 Q6IMF3 Krt1 1,326,149,813 947,186,885.5 0.71 <0.0001 Q6P6Q2...”
• Quantitative proteomic analysis of intracerebral hemorrhage in rats with a focus on brain energy metabolism.
  Liu, Brain and behavior 2018
  • “...alpha 0.68 Erythrocyterelated proteins B1H216 22.63 76.76 49 Hbaa2 Hemoglobin alpha, adult chain 2 67.04 Q62669 2 85.71 47 LOC103694855 Protein Hbbb1 14.25 P11517 6.07 97.28 70 LOC689064 Hemoglobin subunit beta2 12.50 D4A678 18.61 9.52 27 Spta1 Protein Spta1 3.80 Neuroprotection P62161 34.4 89.93 80 Calm1...”
• The different expressed serum proteins in rhCygb treated rat model of liver fibrosis by the optimized two-dimensional gel electrophoresis.
  Cai, PloS one 2017
  • “...Golgi to plasma membrane transport; Intracellular signal transduction 36 Hbb-b1 hemoglobin, beta adult major chain Q62669 16069.28 8.51 137 Oxygen transport from the lung to the various peripheral tissues 37 Beta-2-microglo-bulin P07151 13825.17 8.23 65.7 Immune response; Response to drug 38 Hemoglobin subunit alpha-1/2 P01946 15489.83...”
• More

P22742 Hemoglobin subunit beta from Francolinus pondicerianus
48% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...Q3Y9L5 Q6Y239 Q94FT8 P11025 P18973 P22741 P60523 P68031 P68872 P84479 Q3Y9L6 Q6Y257 Q95190 P11251 P18974 P22742 P60524 P68044 P68873 P84604 Q42665 Q760P9 Q95238 P11342 P18975 P22743 P60525 P68045 P68944 P84609 Q42831 Q760Q0 Q95NK8 P11517 P18976 P23016 P60526 P68046 P68945 P84610 Q43306 Q760Q1 Q966U3 P11748 P18977 P23017...”

P51443 Hemoglobin subunit epsilon from Saguinus midas
48% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...Q90487 Q9YGW2 P10782 P16418 P21379 P51442 P68022 P68236 P83623 Q2MHE0 Q6WN20 Q90ZM4 P10783 P17689 P21380 P51443 P68023 P68237 P83624 Q2PAD4 Q6WN21 Q91473 P10784 P18435 P21667 P51465 P68024 P68238 P83625 Q3C1F3 Q6WN22 Q941P9 P10785 P18436 P21668 P55267 P68025 P68239 P84203 Q3C1F4 Q6WN25 Q941Q1 P10786 P18707 P21766 P56250...”

P51440 Hemoglobin subunit epsilon from Lagothrix lagotricha
48% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...Q9Y0D5 P10778 P15469 P21199 P51438 P68019 P68232 P83612 Q29415 Q6R7N2 Q90485 Q9Y0E6 P10780 P16309 P21200 P51440 P68020 P68234 P83613 Q2KPA3 Q6S9E2 Q90486 Q9YGW1 P10781 P16417 P21201 P51441 P68021 P68235 P83614 Q2KPA4 Q6T497 Q90487 Q9YGW2 P10782 P16418 P21379 P51442 P68022 P68236 P83623 Q2MHE0 Q6WN20 Q90ZM4 P10783 P17689...”

P02046 Hemoglobin subunit delta from Aotus trivirgatus
45% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...O42425 P01945 P01978 P02008 P02044 P02081 P02113 P02208 P07403 P08258 A2TDC2 O76242 P01946 P01979 P02009 P02046 P02082 P02114 P02209 P07404 P08259 A2TDC3 O76243 P01947 P01980 P02010 P02047 P02083 P02115 P02213 P07405 P08260 A2V8C0 O77655 P01948 P01981 P02011 P02048 P02084 P02116 P04237 P07406 P08261 A2V8C1 O81941 P01949...”

P68026 Hemoglobin subunit epsilon from Callithrix jacchus
P68027 Hemoglobin subunit epsilon from Cebuella pygmaea
48% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...Q941P9 P10785 P18436 P21668 P55267 P68025 P68239 P84203 Q3C1F4 Q6WN25 Q941Q1 P10786 P18707 P21766 P56250 P68026 P68240 P84204 Q3MQ26 Q6WN26 Q946U7 P10883 P18969 P21767 P56251 P68027 P68256 P84205 Q3S3T0 Q6WN27 Q947C5 P10885 P18970 P21768 P56285 P68028 P68257 P84206 Q3TUN7 Q6WN28 Q94FG6 P10892 P18971 P21871 P56691 P68029...”
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...Q941Q1 P10786 P18707 P21766 P56250 P68026 P68240 P84204 Q3MQ26 Q6WN26 Q946U7 P10883 P18969 P21767 P56251 P68027 P68256 P84205 Q3S3T0 Q6WN27 Q947C5 P10885 P18970 P21768 P56285 P68028 P68257 P84206 Q3TUN7 Q6WN28 Q94FG6 P10892 P18971 P21871 P56691 P68029 P68258 P84216 Q3U0A6 Q6WN29 Q94FT7 P10893 P18972 P22740 P56692 P68030...”

Q45XH5 Hemoglobin subunit gamma from Dugong dugon
48% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P23019 P61772 P68049 P69905 P84653 Q45XH3 Q7JFN6 Q98TS0 P11751 P18982 P23020 P61773 P68050 P69906 P84790 Q45XH5 Q7JFR7 Q9AWA9 P11752 P18983 P23600 P61774 P68051 P69907 P84791 Q45XH6 Q7LZB9 Q9CWS5 P11753 P18984 P23601 P61775 P68052 P80043 P84792 Q45XH7 Q7LZC1 Q9CY06 P11754 P18985 P23602 P61920 P68053 P80044 P85081 Q45XH8...”

P51442 Hemoglobin subunit epsilon from Pithecia irrorata
48% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...Q9YGW1 P10781 P16417 P21201 P51441 P68021 P68235 P83614 Q2KPA4 Q6T497 Q90487 Q9YGW2 P10782 P16418 P21379 P51442 P68022 P68236 P83623 Q2MHE0 Q6WN20 Q90ZM4 P10783 P17689 P21380 P51443 P68023 P68237 P83624 Q2PAD4 Q6WN21 Q91473 P10784 P18435 P21667 P51465 P68024 P68238 P83625 Q3C1F3 Q6WN22 Q941P9 P10785 P18436 P21668 P55267...”

P10782 Hemoglobin subunit beta from Phalacrocorax carbo
48% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...Q2KPA3 Q6S9E2 Q90486 Q9YGW1 P10781 P16417 P21201 P51441 P68021 P68235 P83614 Q2KPA4 Q6T497 Q90487 Q9YGW2 P10782 P16418 P21379 P51442 P68022 P68236 P83623 Q2MHE0 Q6WN20 Q90ZM4 P10783 P17689 P21380 P51443 P68023 P68237 P83624 Q2PAD4 Q6WN21 Q91473 P10784 P18435 P21667 P51465 P68024 P68238 P83625 Q3C1F3 Q6WN22 Q941P9 P10785...”

O93548 Embryonic 1 beta-globin from Danio rerio
NP_932339 hemoglobin beta embryonic-1.1 from Danio rerio
48% identity, 29% coverage

• Proteomic analysis of zebrafish (Danio rerio) embryos exposed to benzyl benzoate
  Kwon, Environmental science and pollution research international 2023
  • “...3 Q9PV91 Muscle creatine kinase 0.01 4.1E-16 4 A0A0R4IXC8 Tubulin beta chain 0.01 4.1E-16 5 O93548 Embryonic 1 beta-globin 0.658 4.7E-02 6 F6P731 Hemoglobin, alpha embryonic 1.3 0.552 4.7E-04 7 Q6NUT5 Heterogeneous nuclear ribonucleoprotein U-like 1 0.467 1.1E-06 8 Q6NV24 Prostamide/prostaglandin F synthase 0.619 1.2E-02 9...”
• The regulatory role of the adrenergic agonists phenylephrine and isoproterenol on fetal hemoglobin expression and erythroid differentiation.
  Mei, Endocrinology 2013 (PubMed)
  • GeneRIF: The present study identifies the role of phenylephrine and isoproterenol on p38 MAPK and ERK signaling for the stimulation of fetal hemoglobin production and erythroid differentiation.
• Characterization of embryonic globin genes of the zebrafish.
  Brownlie, Developmental biology 2003 (PubMed)
  • GeneRIF: Multiple copies of this gene were found in genomic DNA isolated from haploid embryos.
• [Joint locus of a/b-globin genes in Danio rerio is segregated into structural subdomains active at different stages of development].
  Dolgushin, Molekuliarnaia biologiia (PubMed)
  • GeneRIF: Joint locus of alpha/beta-globin genes in Danio rerio is segregated into structural subdomains active at different stages of development.

3at5B / E5RWQ1 Side-necked turtle (pleurodira, chelonia, reptilia) hemoglobin: cdna- derived primary structures and x-ray crystal structures of hb a (see paper)
44% identity, 28% coverage

• Ligand: protoporphyrin ix containing fe (3at5B)

O95408 Beta globin (Fragment) from Homo sapiens
45% identity, 74% coverage

• iTRAQ and PRM-Based Proteomic Analysis Provides New Insights into Mechanisms of Response to Triple Therapy in Patients with Rheumatoid Arthritis
  Chen, Journal of inflammation research 2021
  • “...1.459135 0.018458 P35443 THBS4 Thrombospondin-4 1.448261 0.020889 G3XAP6 COMP Cartilage oligomeric matrix protein 1.443717 0.021991 O95408 HBB Beta globin (Fragment) 1.441775 0.022478 A0A075B6L1 IGLC7 Ig lambda-7 chain C region (Fragment) OS=Homo sapiens 1.418328 0.029207 A0A068LN03 IG Ig heavy chain variable region (Fragment) 1.415796 0.030036 A0A0F7SZ86 IGHV2-70...”
• Plasma disturbance of phospholipid metabolism in major depressive disorder by integration of proteomics and metabolomics.
  Gui, Neuropsychiatric disease and treatment 2018
  • “...B4YUQ1 TGM4 0.668 3.79E 03 A0A0C4DH72 IGKV1-6 0.663 3.97E 02 A0A0F7W082 HLA-A 0.597 9.76E 03 O95408 HBB 0.593 4.87E 03 A0A0F7TAT3 IGHV4-39 0.574 4.22E 03 P02787 TF 0.574 2.25E 04 A0A087X0Q4 IGKV2-40 0.567 4.60E 03 A0A0A0MTA3 IGKJ5 0.524 6.24E 03 Q15828 CST6 0.443 9.47E 03 Q6MZU6...”

HBB1_PSEUR / P83624 Hemoglobin subunit beta-1; Beta-1-globin; Hemoglobin beta-1 chain from Pseudaphritis urvillii (Congolli) (Freshwater flathead) (see paper)
45% identity, 29% coverage

• function: Involved in oxygen transport from gills to the various peripheral tissues
  subunit: Hb1 is a heterotetramer of two alpha chains and two beta-1 chains.
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P16418 P21379 P51442 P68022 P68236 P83623 Q2MHE0 Q6WN20 Q90ZM4 P10783 P17689 P21380 P51443 P68023 P68237 P83624 Q2PAD4 Q6WN21 Q91473 P10784 P18435 P21667 P51465 P68024 P68238 P83625 Q3C1F3 Q6WN22 Q941P9 P10785 P18436 P21668 P55267 P68025 P68239 P84203 Q3C1F4 Q6WN25 Q941Q1 P10786 P18707 P21766 P56250 P68026 P68240 P84204...”
• Structure and function of the Gondwanian hemoglobin of Pseudaphritis urvillii, a primitive notothenioid fish of temperate latitudes
  Verde, Protein science : a publication of the Protein Society 2004
  • “...TrEMBL knowledgebase under the accession numbers P83623 (), P83624 (1), P83625 (2). Acknowledgments This study is in the framework of the Italian National...”

4h2lB / C5MQT7 Deer mouse hemoglobin in hydrated format (see paper)
45% identity, 29% coverage

• Ligand: protoporphyrin ix containing fe (4h2lB)

3bj2B / D0VWV3 Met-perch hemoglobin at ph 6.3 (see paper)
48% identity, 29% coverage

• Ligand: protoporphyrin ix containing fe (3bj2B)

P80216 Hemoglobin subunit beta from Aptenodytes forsteri
45% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P11754 P18985 P23602 P61920 P68053 P80044 P85081 Q45XH8 Q7LZC2 Q9CY10 P11755 P18986 P23740 P61921 P68054 P80216 P85082 Q45XI4 Q7LZC3 Q9CZK5 P11756 P18987 P23741 P61947 P68055 P80270 Q03902 Q45XI5 Q7LZL6 Q9D0B2 P11757 P18988 P24291 P61948 P68056 P80271 Q0PB48 Q45XI6 Q7LZM6 Q9DF25 P11758 P18989 P24292 P62363 P68057 P80726...”

XP_041575112 hemoglobin subunit rho-like from Taeniopygia guttata
45% identity, 31% coverage

• Genomic organization of zebra finch alpha and beta globin genes and their expression in primitive and definitive blood in comparison with globins in chicken.
  Alev, Development genes and evolution 2009 (PubMed)
  • GeneRIF: Adult finch blood has a globin profile similar to that of adult chicken, with high levels of beta3 and alpha3 and moderate levels of alpha2.

Q98905 Hemoglobin subunit beta from Chelonoidis carbonarius
45% identity, 29% coverage

• A Placenta Derived C-Terminal Fragment of β-Hemoglobin With Combined Antibacterial and Antiviral Activity
  Groß, Frontiers in microbiology 2020
  • “...(Australian echidna) P02110 ; Xenopus laevis (African clawed frog) P02132 ; Chelonoidis carbonarius (Red-footed tortoise) Q98905 ; Meleagris gallopavo (Common turkey) P81023 ; Gallus gallus (Chicken) P02112 ; Danio rerio (Zebrafish) Q90486 ; Protein sequences were aligned using Clustal W 3 and residue conservation was determined...”
• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P68047 P69891 P84611 Q45V69 Q760Q2 Q96FH6 P11749 P18978 P23018 P60530 P68048 P69892 P84652 Q45V70 Q78PA4 Q98905 P11750 P18981 P23019 P61772 P68049 P69905 P84653 Q45XH3 Q7JFN6 Q98TS0 P11751 P18982 P23020 P61773 P68050 P69906 P84790 Q45XH5 Q7JFR7 Q9AWA9 P11752 P18983 P23600 P61774 P68051 P69907 P84791 Q45XH6 Q7LZB9 Q9CWS5...”

LOC106048582 hemoglobin subunit beta-like from Anser cygnoides
45% identity, 29% coverage

• Development of myofibers and muscle transcriptomic analysis in growing Yili geese
  Zhao, Poultry science 2024
  • “...106042983 LPAR4 Lysophosphatidic acid receptor 4 106034821 SH3TC1 SH3 domain and tetratricopeptide repeats 1 106048582 LOC106048582 Hemoglobin subunit beta-like 106030443 ANGPT2 Angiopoietin 2 106046557 LOC106046557 Kelch-like protein 4 106036765 PLXND1 Plexin D1 106042247 CD93 CD93 molecule 106038291 LDHB Lactate dehydrogenase B 106042643 NRP1 Neuropilin 1 106032859...”

Q4TZM4 Hemoglobin beta chain (Fragment) from Homo sapiens
49% identity, 39% coverage

• iTRAQ and PRM-Based Proteomic Analysis Provides New Insights into Mechanisms of Response to Triple Therapy in Patients with Rheumatoid Arthritis
  Chen, Journal of inflammation research 2021
  • “...variant 2.56063 4.16E-12 A0A0K0K1L1 HEL-S-282 Epididymis secretory protein Li 282 2.467484 2.76E-11 [ 12 ] Q4TZM4 HBB Hemoglobin beta chain (Fragment) 2.253802 2.07E-09 Q05315 CLC Galectin-10 2.226055 3.61E-09 * P02042 HBD Hemoglobin subunit delta 2.135777 2.19E-08 P00915 CA1 Carbonic anhydrase 1 2.1189 3.06E-08 I1VZV6 HBA1 Hemoglobin...”
• Proteomic analysis of decidua in patients with recurrent pregnancy loss (RPL) reveals mitochondrial oxidative stress dysfunction
  Yin, Clinical proteomics 2021
  • “...0.467543161 0.0169378 C8C504 Beta-globin 0.459856836 0.00578593 K7EP20 Dedicator of cytokinesis protein 6 (Fragment) 0.459262528 0.0211759 Q4TZM4 Hemoglobin beta chain (Fragment) 0.453442055 0.00422012 Q6EVJ6 Peptidyl arginine deiminase type IV (Fragment) 0.449186304 0.00218377 X6R5I7 Regulator of telomere elongation helicase 1 (Fragment) 0.44450906 0.0019814 H7C2R1 NADH dehydrogenase [ubiquinone] 1...”
• Quantitative proteomic analysis for high-throughput screening of differential glycoproteins in hepatocellular carcinoma serum
  Gao, Cancer biology & medicine 2015
  • “...2 OS=Homo sapiens GN=CFHR2 PE=1 SV=1 - [FHR2_HUMAN] 27.04 2 3 7 270 30.6 6.38 Q4TZM4 Hemoglobin beta chain (Fragment) OS=Homo sapiens GN=HBB PE=2 SV=1 - [Q4TZM4_HUMAN] 88.12 32 3 7 101 11.0 6.52 Q5CZ94 Putative uncharacterized protein DKFZp781M0386 OS=Homo sapiens GN=DKFZp781M0386 PE=2 SV=1 - [Q5CZ94_HUMAN]...”

P02116 Hemoglobin subunit beta from Ara ararauna
45% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P01980 P02010 P02047 P02083 P02115 P02213 P07405 P08260 A2V8C0 O77655 P01948 P01981 P02011 P02048 P02084 P02116 P04237 P07406 P08261 A2V8C1 O81941 P01949 P01982 P02012 P02049 P02085 P02117 P04238 P07407 P08422 A2V8C2 O88752 P01950 P01983 P02013 P02050 P02086 P02118 P04239 P07408 P08423 A4GTS5 O88754 P01951 P01984 P02014...”

Q52MT0 Beta globin (Fragment) from Homo sapiens
49% identity, 37% coverage

• Proteomic analysis of decidua in patients with recurrent pregnancy loss (RPL) reveals mitochondrial oxidative stress dysfunction
  Yin, Clinical proteomics 2021
  • “...HCG1745306, isoform CRA_a 0.381102252 0.00686417 E9PJK3 Myomegalin 0.374237369 0.00223712 Q3LR79 Hemoglobin beta (Fragment) 0.373133311 0.0106368 Q52MT0 Beta globin (Fragment) 0.36879883 0.00906274 P02042 Hemoglobin subunit delta 0.340566569 0.00702286 Q8N4C8 Misshapen-like kinase 1 0.33915893 0.00302351 Q4ZGM8 Hemoglobin alpha-2 globin mutant (Fragment) 0.253926844 0.00191696 Q9UK54 Hemoglobin beta subunit variant...”

P02124 Hemoglobin subunit beta from Rhea americana
45% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...P01987 P02017 P02054 P02090 P02123 P04244 P07412 P08851 A9JSP7 O96457 P01956 P01988 P02018 P02055 P02091 P02124 P04245 P07413 P08852 A9XDF6 P01923 P01957 P01989 P02019 P02057 P02092 P02125 P04246 P07414 P08853 B0BL34 P01924 P01958 P01990 P02020 P02058 P02093 P02126 P04252 P07415 P09105 B0BL35 P01926 P01959 P01991 P02021...”

O88753 Epsilon 2 globin from Rattus norvegicus
45% identity, 29% coverage

• Integrated proteomics and metabolomics analysis of lumbar in a rat model of osteoporosis treated with Gushukang capsules.
  Lin, BMC complementary medicine and therapies 2022
  • “...name OVX VS SHAM P value Difference multiple Regulation D3ZAT0 RCG32168 Svs3b 0.001 6.329 Up O88753 Epsilon 2 globin Hbe2 0.001 5.373 Up B2RYM6 Zc3hc1 protein Zc3hc1 0.010 2.493 Up Q6AY07 Fructose-bisphosphate aldolase Aldoart2 0.039 2.284 Up E9PTV9 Glyceraldehyde-3-phosphate dehydrogenase 0.002 2.071 Up P62762 Visinin-like protein...”

P21668 Hemoglobin subunit beta from Psittacula krameri
45% identity, 29% coverage

• A rapid method for characterization of protein relatedness using feature vectors.
  Carr, PloS one 2010
  • “...Q2PAD4 Q6WN21 Q91473 P10784 P18435 P21667 P51465 P68024 P68238 P83625 Q3C1F3 Q6WN22 Q941P9 P10785 P18436 P21668 P55267 P68025 P68239 P84203 Q3C1F4 Q6WN25 Q941Q1 P10786 P18707 P21766 P56250 P68026 P68240 P84204 Q3MQ26 Q6WN26 Q946U7 P10883 P18969 P21767 P56251 P68027 P68256 P84205 Q3S3T0 Q6WN27 Q947C5 P10885 P18970 P21768...”

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Statistics

How It Works

PaperBLAST builds a database of protein sequences that are linked to scientific articles. These links come from automated text searches against the articles in EuropePMC and from manually-curated information from GeneRIF, UniProtKB/Swiss-Prot, BRENDA, CAZy (as made available by dbCAN), BioLiP, CharProtDB, MetaCyc, EcoCyc, TCDB, REBASE, the Fitness Browser, and a subset of the European Nucleotide Archive with the /experiment tag. Given this database and a protein sequence query, PaperBLAST uses protein-protein BLAST to find similar sequences with E < 0.001.

To build the database, we query EuropePMC with locus tags, with RefSeq protein identifiers, and with UniProt accessions. We obtain the locus tags from RefSeq or from MicrobesOnline. We use queries of the form "locus_tag AND genus_name" to try to ensure that the paper is actually discussing that gene. Because EuropePMC indexes most recent biomedical papers, even if they are not open access, some of the links may be to papers that you cannot read or that our computers cannot read. We query each of these identifiers that appears in the open access part of EuropePMC, as well as every locus tag that appears in the 500 most-referenced genomes, so that a gene may appear in the PaperBLAST results even though none of the papers that mention it are open access. We also incorporate text-mined links from EuropePMC that link open access articles to UniProt or RefSeq identifiers. (This yields some additional links because EuropePMC uses different heuristics for their text mining than we do.)

For every article that mentions a locus tag, a RefSeq protein identifier, or a UniProt accession, we try to select one or two snippets of text that refer to the protein. If we cannot get access to the full text, we try to select a snippet from the abstract, but unfortunately, unique identifiers such as locus tags are rarely provided in abstracts.

PaperBLAST also incorporates manually-curated protein functions:

• Proteins from NCBI's RefSeq are included if a GeneRIF entry links the gene to an article in PubMed^®. GeneRIF also provides a short summary of the article's claim about the protein, which is shown instead of a snippet.
• Proteins from Swiss-Prot (the curated part of UniProt) are included if the curators identified experimental evidence for the protein's function (evidence code ECO:0000269). For these proteins, the fields of the Swiss-Prot entry that describe the protein's function are shown (with bold headings).
• Proteins from BRENDA, a curated database of enzymes, are included if they are linked to a paper in PubMed and their full sequence is known.
• Every protein from the non-redundant subset of BioLiP, a database of ligand-binding sites and catalytic residues in protein structures, is included. Since BioLiP itself does not include descriptions of the proteins, those are taken from the Protein Data Bank. Descriptions from PDB rely on the original submitter of the structure and cannot be updated by others, so they may be less reliable. (For SitesBLAST and Sites on a Tree, we use a larger subset of BioLiP so that every ligand is represented among a group of structures with similar sequences, but for PaperBLAST, we use the non-redundant set provided by BioLiP.)
• Every protein from EcoCyc, a curated database of the proteins in Escherichia coli K-12, is included, regardless of whether they are characterized or not.
• Proteins from the MetaCyc metabolic pathway database are included if they are linked to a paper in PubMed and their full sequence is known.
• Proteins from the Transport Classification Database (TCDB) are included if they have known substrate(s), have reference(s), and are not described as uncharacterized or putative. (Some of the references are not visible on the PaperBLAST web site.)
• Every protein from CharProtDB, a database of experimentally characterized protein annotations, is included.
• Proteins from the CAZy database of carbohydrate-active enzymes are included if they are associated with an Enzyme Classification number. Even though CAZy does not provide links from individual protein sequences to papers, these should all be experimentally-characterized proteins.
• Proteins from the REBASE database of restriction enzymes are included if they have known specificity.
• Every protein with an evidence-based reannotation (based on mutant phenotypes) in the Fitness Browser is included.
• Sequence-specific transcription factors (including sigma factors and DNA-binding response regulators) with experimentally-determined DNA binding sites from the PRODORIC database of gene regulation in prokaryotes.
• Putative transcription factors from RegPrecise that have manually-curated predictions for their binding sites. These predictions are based on conserved putative regulatory sites across genomes that contain similar transcription factors, so PaperBLAST clusters the TFs at 70% identity and retains just one member of each cluster.
• Coding sequence (CDS) features from the European Nucleotide Archive (ENA) are included if the /experiment tag is set (implying that there is experimental evidence for the annotation), the nucleotide entry links to paper(s) in PubMed, and the nucleotide entry is from the STD data class (implying that these are targeted annotated sequences, not from shotgun sequencing). Also, to filter out genes whose transcription or translation was detected, but whose function was not studied, nucleotide entries or papers with more than 25 such proteins are excluded. Descriptions from ENA rely on the original submitter of the sequence and cannot be updated by others, so they may be less reliable.

Except for GeneRIF and ENA, the curated entries include a short curated description of the protein's function. For entries from BioLiP, the protein's function may not be known beyond binding to the ligand. Many of these entries also link to articles in PubMed.

For more information see the PaperBLAST paper (mSystems 2017) or the code. You can download PaperBLAST's database here.

Changes to PaperBLAST since the paper was written:

• November 2023: incorporated PRODORIC and RegPrecise. Many PRODORIC entries were not linked to a protein sequence (no UniProt identifier), so we added this information.
• February 2023: BioLiP changed their download format. PaperBLAST now includes their non-redundant subset. SitesBLAST and Sites on a Tree use a larger non-redundant subset that ensures that every ligand is represented within each cluster. This should ensure that every binding site is represented.
• June 2022: incorporated some coding sequences from ENA with the /experiment tag.
• March 2022: incorporated BioLiP.
• April 2020: incorporated TCDB.
• April 2019: EuropePMC now returns table entries in their search results. This has expanded PaperBLAST's database, but most of the new entries are of low relevance, and the resulting snippets are often just lists of locus tags with annotations.
• February 2018: the alignment page reports the conservation of the hit's functional sites (if available from from Swiss-Prot or UniProt)
• January 2018: incorporated BRENDA.
• December 2017: incorporated MetaCyc, CharProtDB, CAZy, REBASE, and the reannotations from the Fitness Browser.
• September 2017: EuropePMC no longer returns some table entries in their search results. This has shrunk PaperBLAST's database, but has also reduced the number of low-relevance hits.

Many of these changes are described in Interactive tools for functional annotation of bacterial genomes.

Secrets

PaperBLAST cannot provide snippets for many of the papers that are published in non-open-access journals. This limitation applies even if the paper is marked as "free" on the publisher's web site and is available in PubmedCentral or EuropePMC. If a journal that you publish in is marked as "secret," please consider publishing elsewhere.

Omissions from the PaperBLAST Database

Many important articles are missing from PaperBLAST, either because the article's full text is not in EuropePMC (as for many older articles), or because the paper does not mention a protein identifier such as a locus tag, or because of PaperBLAST's heuristics. If you notice an article that characterizes a protein's function but is missing from PaperBLAST, please notify the curators at UniProt or add an entry to GeneRIF. Entries in either of these databases will eventually be incorporated into PaperBLAST. Note that to add an entry to UniProt, you will need to find the UniProt identifier for the protein. If the protein is not already in UniProt, you can ask them to create an entry. To add an entry to GeneRIF, you will need an NCBI Gene identifier, but unfortunately many prokaryotic proteins in RefSeq do not have corresponding Gene identifers.

References

PaperBLAST: Text-mining papers for information about homologs.
M. N. Price and A. P. Arkin (2017). mSystems, 10.1128/mSystems.00039-17.

Europe PMC in 2017.
M. Levchenko et al (2017). Nucleic Acids Research, 10.1093/nar/gkx1005.

Gene indexing: characterization and analysis of NLM's GeneRIFs.
J. A. Mitchell et al (2003). AMIA Annu Symp Proc 2003:460-464.

UniProt: the universal protein knowledgebase.
The UniProt Consortium (2016). Nucleic Acids Research, 10.1093/nar/gkw1099.

BRENDA in 2017: new perspectives and new tools in BRENDA.
S. Placzek et al (2017). Nucleic Acids Research, 10.1093/nar/gkw952.

The EcoCyc database: reflecting new knowledge about Escherichia coli K-12.
I. M. Keeseler et al (2016). Nucleic Acids Research, 10.1093/nar/gkw1003.

The MetaCyc database of metabolic pathways and enzymes.
R. Caspi et al (2018). Nucleic Acids Research, 10.1093/nar/gkx935.

CharProtDB: a database of experimentally characterized protein annotations.
R. Madupu et al (2012). Nucleic Acids Research, 10.1093/nar/gkr1133.

The carbohydrate-active enzymes database (CAZy) in 2013.
V. Lombard et al (2014). Nucleic Acids Research, 10.1093/nar/gkt1178.

The Transporter Classification Database (TCDB): recent advances
M. H. Saier, Jr. et al (2016). Nucleic Acids Research, 10.1093/nar/gkv1103.

REBASE - a database for DNA restriction and modification: enzymes, genes and genomes.
R. J. Roberts et al (2015). Nucleic Acids Research, 10.1093/nar/gku1046.

Deep annotation of protein function across diverse bacteria from mutant phenotypes.
M. N. Price et al (2016). bioRxiv, 10.1101/072470.