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PaperBLAST Hits for BRENDA::P0A6L2 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) (Escherichia coli) (292 a.a., MFTGSIVAIV...)

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Predict protein localization: PSORTb

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Found 250 similar proteins in the literature:

DapA / b2478 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Escherichia coli K-12 substr. MG1655 (see 24 papers)
dapA / P0A6L2 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Escherichia coli (strain K12) (see 23 papers)
DAPA_ECOLI / P0A6L2 4-hydroxy-tetrahydrodipicolinate synthase; HTPA synthase; EC 4.3.3.7 from Escherichia coli (strain K12) (see 11 papers)
P0A6L2 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Escherichia coli (see 15 papers)
NP_416973 4-hydroxy-tetrahydrodipicolinate synthase from Escherichia coli str. K-12 substr. MG1655
P0A6L3 4-hydroxy-tetrahydrodipicolinate synthase from Shigella flexneri
b2478 dihydrodipicolinate synthase from Escherichia coli str. K-12 substr. MG1655
100% identity, 100% coverage

5t25A / B7M7I1 Kinetic, spectral and structural characterization of the slow binding inhibitor acetopyruvate with dihydrodipicolinate synthase from escherichia coli.
100% identity, 100% coverage

NP_311367 dihydrodipicolinate synthase from Escherichia coli O157:H7 str. Sakai
Q3YZ74 4-hydroxy-tetrahydrodipicolinate synthase from Shigella sonnei (strain Ss046)
100% identity, 100% coverage

WP_061350668 4-hydroxy-tetrahydrodipicolinate synthase from Escherichia coli
100% identity, 100% coverage

WP_023259918 4-hydroxy-tetrahydrodipicolinate synthase from Salmonella enterica subsp. enterica serovar Manhattan str.
91% identity, 100% coverage

dhdps / CAC50571.1 dihydrodipicolinate synthetase from Yersinia enterocolitica (see paper)
81% identity, 100% coverage

WP_004941701 4-hydroxy-tetrahydrodipicolinate synthase from Serratia marcescens
79% identity, 100% coverage

YP_071290 dihydrodipicolinate synthase from Yersinia pseudotuberculosis IP 32953
78% identity, 98% coverage

APL_0899 dihydrodipicolinate synthase from Actinobacillus pleuropneumoniae L20
63% identity, 99% coverage

HI0255 dihydrodipicolinate synthetase (dapA) from Haemophilus influenzae Rd KW20
59% identity, 98% coverage

AHML_04540 4-hydroxy-tetrahydrodipicolinate synthase from Aeromonas hydrophila ML09-119
62% identity, 99% coverage

A5F699 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Vibrio cholerae (see paper)
58% identity, 99% coverage

PP1237 dihydrodipicolinate synthase from Pseudomonas putida KT2440
57% identity, 99% coverage

DAPA_PSEAE / Q9I4W3 4-hydroxy-tetrahydrodipicolinate synthase; HTPA synthase; EC 4.3.3.7 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
Q9I4W3 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Pseudomonas aeruginosa (see 2 papers)
PA1010 dihydrodipicolinate synthase from Pseudomonas aeruginosa PAO1
57% identity, 100% coverage

BN5_2718 4-hydroxy-tetrahydrodipicolinate synthase from Pseudomonas oleovorans CECT 5344
56% identity, 100% coverage

3puoA / Q9I4W3 Crystal structure of dihydrodipicolinate synthase from pseudomonas aeruginosa(psdhdps)complexed with l-lysine at 2.65a resolution (see paper)
57% identity, 100% coverage

4dxvA / D0CFC3 Crystal structure of dihydrodipicolinate synthase from acinetobacter baumannii complexed with mg and cl ions at 1.80 a resolution
51% identity, 100% coverage

4pfmA / A9DKW4 Shewanella benthica dhdps with lysine and pyruvate
51% identity, 98% coverage

CBU_1222 dihydrodipicolinate synthase from Coxiella burnetii RSA 493
48% identity, 98% coverage

RS_RS05700 4-hydroxy-tetrahydrodipicolinate synthase from Ralstonia pseudosolanacearum GMI1000
51% identity, 99% coverage

DAPA_NEIMB / Q9JZR4 4-hydroxy-tetrahydrodipicolinate synthase; HTPA synthase; EC 4.3.3.7 from Neisseria meningitidis serogroup B (strain ATCC BAA-335 / MC58) (see paper)
Q9JZR4 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Neisseria meningitidis (see paper)
49% identity, 100% coverage

NGO0947 putative dihydrodipicolinate synthase from Neisseria gonorrhoeae FA 1090
49% identity, 100% coverage

YP_003106592 dihydrodipicolinate synthase from Brucella microti CCM 4915
45% identity, 100% coverage

WP_006165259 4-hydroxy-tetrahydrodipicolinate synthase from Brucella sp. 63/311
45% identity, 100% coverage

WP_021587874 4-hydroxy-tetrahydrodipicolinate synthase from Brucella intermedia
45% identity, 100% coverage

NP_697660 dihydrodipicolinate synthase from Brucella suis 1330
44% identity, 100% coverage

YP_003432886 dihydrodipicolinate synthase from Hydrogenobacter thermophilus TK-6
48% identity, 99% coverage

BMEI1301 DIHYDRODIPICOLINATE SYNTHASE from Brucella melitensis 16M
44% identity, 95% coverage

BAB1_0666 Dihydrodipicolinate synthetase:Dihydrodipicolinate synthase subfamily from Brucella melitensis biovar Abortus 2308
44% identity, 100% coverage

W6R260 4-hydroxy-tetrahydrodipicolinate synthase from Pseudomonas pseudoalcaligenes (strain CECT 5344)
43% identity, 90% coverage

SAR11_1062 dihydrodipicolinate synthase from Candidatus Pelagibacter ubique HTCC1062
46% identity, 100% coverage

dapA / Q04796 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Bacillus subtilis (strain 168) (see paper)
BSU16770 dihydrodipicolinate synthase from Bacillus subtilis subsp. subtilis str. 168
46% identity, 96% coverage

O67216 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Aquifex aeolicus (see paper)
46% identity, 99% coverage

DAPA_THEMA / Q9X1K9 4-hydroxy-tetrahydrodipicolinate synthase; HTPA synthase; EC 4.3.3.7 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see 2 papers)
TM1521 dihydrodipicolinate synthase from Thermotoga maritima MSB8
43% identity, 99% coverage

DAPA_RHIML / Q07607 4-hydroxy-tetrahydrodipicolinate synthase; HTPA synthase; Protein MosA; EC 4.3.3.7 from Rhizobium meliloti (Ensifer meliloti) (Sinorhizobium meliloti) (see 2 papers)
Q07607 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Sinorhizobium meliloti (see 2 papers)
45% identity, 100% coverage

1o5kA / Q9X1K9 Crystal structure of dihydrodipicolinate synthase (tm1521) from thermotoga maritima at 1.80 a resolution
43% identity, 99% coverage

MM1201 Dihydrodipicolinate synthase from Methanosarcina mazei Goe1
45% identity, 100% coverage

CLJU_c04300 4-hydroxy-tetrahydrodipicolinate synthase from Clostridium ljungdahlii DSM 13528
44% identity, 100% coverage

CSUI_001859 dihydrodipicolinate synthase from Cystoisospora suis
48% identity, 92% coverage

dapA / Q65JG7 dihydrodipicolinate synthase subunit (EC 4.3.3.7) from Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46) (see paper)
44% identity, 95% coverage

X276_18055 4-hydroxy-tetrahydrodipicolinate synthase from Clostridium beijerinckii NRRL B-598
44% identity, 98% coverage

Clocel_3115 4-hydroxy-tetrahydrodipicolinate synthase from Clostridium cellulovorans 743B
44% identity, 99% coverage

DAPA_AGRFC / Q8UGL3 4-hydroxy-tetrahydrodipicolinate synthase; HTPA synthase; EC 4.3.3.7 from Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58)) (see paper)
Q8UGL3 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Agrobacterium tumefaciens (see 2 papers)
Atu1024 dihydrodipicolinate synthase from Agrobacterium tumefaciens str. C58 (Cereon)
45% identity, 99% coverage

4i7wA Agrobacterium tumefaciens dhdps with lysine and pyruvate
44% identity, 99% coverage

RHE_RS07055 4-hydroxy-tetrahydrodipicolinate synthase from Rhizobium etli CFN 42
45% identity, 99% coverage

X276_01925 4-hydroxy-tetrahydrodipicolinate synthase from Clostridium beijerinckii NRRL B-598
43% identity, 100% coverage

DAPA_METJA / Q57695 4-hydroxy-tetrahydrodipicolinate synthase; HTPA synthase; EC 4.3.3.7 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
WP_010869742 4-hydroxy-tetrahydrodipicolinate synthase from Methanocaldococcus jannaschii DSM 2661
45% identity, 100% coverage

LIC10842 dihydrodipicolinate synthase protein from Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130
43% identity, 94% coverage

LIMLP_13480 4-hydroxy-tetrahydrodipicolinate synthase from Leptospira interrogans serovar Manilae
43% identity, 99% coverage

N007_06870 4-hydroxy-tetrahydrodipicolinate synthase from Alicyclobacillus acidoterrestris ATCC 49025
42% identity, 99% coverage

Q8RBI5 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Caldanaerobacter subterraneus subsp. tengcongensis (see paper)
42% identity, 98% coverage

dapA2 dihydrodipicolinate synthase; EC 4.2.1.52 from Bacillus anthracis (see paper)
BA3935 dihydrodipicolinate synthase from Bacillus anthracis str. Ames
42% identity, 96% coverage

CD3223 dihydrodipicolinate synthase from Clostridium difficile 630
41% identity, 99% coverage

CPF_2161 dihydrodipicolinate synthase from Clostridium perfringens ATCC 13124
40% identity, 100% coverage

CPE1905 dihydrodipicolinate synthase from Clostridium perfringens str. 13
40% identity, 100% coverage

MMP0576 Dihydrodipicolinate synthase from Methanococcus maripaludis S2
44% identity, 99% coverage

Q6G468 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Bartonella henselae (see paper)
41% identity, 99% coverage

Q3M723 4-hydroxy-tetrahydrodipicolinate reductase (EC 1.17.1.8) from Trichormus variabilis (see paper)
41% identity, 99% coverage

CD3225 dihydrodipicolinate synthase from Clostridium difficile 630
41% identity, 99% coverage

5ktlA / Q3M723 Dihydrodipicolinate synthase from the industrial and evolutionarily important cyanobacteria anabaena variabilis. (see paper)
41% identity, 99% coverage

7lvlA / A0A0F4VK59 Dihydrodipicolinate synthase bound with allosteric inhibitor (s)- lysine from candidatus liberibacter solanacearum
42% identity, 98% coverage

EfmE1162_2260 4-hydroxy-tetrahydrodipicolinate synthase from Enterococcus faecium E1162
41% identity, 98% coverage

Q836D1 4-hydroxy-tetrahydrodipicolinate synthase from Enterococcus faecalis (strain ATCC 700802 / V583)
EF1184 dihydrodipicolinate synthase from Enterococcus faecalis V583
41% identity, 97% coverage

VspiD_010100011370 dihydrodipicolinate synthase from Verrucomicrobium spinosum DSM 4136
44% identity, 99% coverage

PHYSODRAFT_349787 hypothetical protein from Phytophthora sojae
39% identity, 100% coverage

Cj0806 dihydrodipicolinate synthase from Campylobacter jejuni subsp. jejuni NCTC 11168
38% identity, 96% coverage

HVO_1101 dihydrodipicolinate synthase from Haloferax volcanii DS2
43% identity, 94% coverage

DSY2498 hypothetical protein from Desulfitobacterium hafniense Y51
39% identity, 91% coverage

7kkdB / Q9PPB4 Dihydrodipicolinate synthase (dhdps) from c.Jejuni, n84a mutant with pyruvate bound in the active site and r,r-bislysine bound at the allosteric site
38% identity, 94% coverage

slr0550 dihydrodipicolinate synthase from Synechocystis sp. PCC 6803
41% identity, 97% coverage

O25657 4-hydroxy-tetrahydrodipicolinate synthase from Helicobacter pylori (strain ATCC 700392 / 26695)
HP1013 dihydrodipicolinate synthetase (dapA) from Helicobacter pylori 26695
40% identity, 88% coverage

4fhaA Structure of dihydrodipicolinate synthase from streptococcus pneumoniae,bound to pyruvate and lysine
39% identity, 92% coverage

SP_1014 dihydrodipicolinate synthase from Streptococcus pneumoniae TIGR4
40% identity, 86% coverage

CG479_RS05485 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase from Bacillus cytotoxicus
37% identity, 93% coverage

spr0919 Dihydrodipicolinate synthase from Streptococcus pneumoniae R6
SPD_0901 dihydrodipicolinate synthase from Streptococcus pneumoniae D39
40% identity, 86% coverage

5ud6C / M1V4H9 Crystal structure of dhdps from cyanidioschyzon merolae with lysine bound
41% identity, 98% coverage

Ssal_00884 4-hydroxy-tetrahydrodipicolinate synthase from Streptococcus salivarius 57.I
38% identity, 91% coverage

GPNADHDJ_01975 4-hydroxy-tetrahydrodipicolinate synthase from Stenotrophomonas maltophilia
42% identity, 92% coverage

CD16_RS00745 4-hydroxy-tetrahydrodipicolinate synthase from Candidatus Liberibacter asiaticus
39% identity, 93% coverage

Gasu_29240 dihydrodipicolinate synthase from Galdieria sulphuraria
38% identity, 81% coverage

TSC_c10420 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase from Thermus scotoductus SA-01
35% identity, 99% coverage

lp_2685 dihydrodipicolinate synthase from Lactobacillus plantarum WCFS1
F9URH0 4-hydroxy-tetrahydrodipicolinate synthase from Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
39% identity, 97% coverage

Marky_1261 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase from Marinithermus hydrothermalis DSM 14884
36% identity, 97% coverage

Mrub_1335 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase from Meiothermus ruber DSM 1279
35% identity, 93% coverage

Riean_0023 4-hydroxy-tetrahydrodipicolinate synthase from Riemerella anatipestifer ATCC 11845 = DSM 15868
37% identity, 96% coverage

Trad_1893 4-hydroxy-tetrahydrodipicolinate synthase from Truepera radiovictrix DSM 17093
36% identity, 96% coverage

A8GNF1 4-hydroxy-tetrahydrodipicolinate synthase from Rickettsia akari (strain Hartford)
34% identity, 96% coverage

TTHA0957 dihydrodipicolinate synthase from Thermus thermophilus HB8
34% identity, 98% coverage

TTC0591 No description from Thermus thermophilus HB27
34% identity, 98% coverage

MW1283 dihydrodipicolinate synthase from Staphylococcus aureus subsp. aureus MW2
36% identity, 97% coverage

Q92I25 4-hydroxy-tetrahydrodipicolinate synthase from Rickettsia conorii (strain ATCC VR-613 / Malish 7)
33% identity, 96% coverage

DAPA_STAAR / Q6GH13 4-hydroxy-tetrahydrodipicolinate synthase; HTPA synthase; EC 4.3.3.7 from Staphylococcus aureus (strain MRSA252) (see paper)
Q6GH13 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Staphylococcus aureus (see 2 papers)
SAR1407 dihydrodipicolinate synthase from Staphylococcus aureus subsp. aureus MRSA252
36% identity, 97% coverage

DAPA_STAAC / Q5HG25 4-hydroxy-tetrahydrodipicolinate synthase; HTPA synthase; EC 4.3.3.7 from Staphylococcus aureus (strain COL) (see paper)
Q5HG25 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Staphylococcus aureus (see paper)
USA300HOU_RS07105 4-hydroxy-tetrahydrodipicolinate synthase from Staphylococcus aureus subsp. aureus USA300_TCH1516
SAOUHSC_01396 dihydrodipicolinate synthase from Staphylococcus aureus subsp. aureus NCTC 8325
SAUSA300_1288 dihydrodipicolinate synthase from Staphylococcus aureus subsp. aureus USA300_FPR3757
NWMN_1306 dihydrodipicolinate synthase from Staphylococcus aureus subsp. aureus str. Newman
SACOL1430 dihydrodipicolinate synthase from Staphylococcus aureus subsp. aureus COL
36% identity, 96% coverage

3di1B / Q5HG25 Crystal structure of the staphylococcus aureus dihydrodipicolinate synthase-pyruvate complex (see paper)
36% identity, 97% coverage

SA1227 dihydrodipicolinate synthase from Staphylococcus aureus subsp. aureus N315
SAV1395 dihydrodipicolinate synthase from Staphylococcus aureus subsp. aureus Mu50
35% identity, 97% coverage

BLJ_0490 4-hydroxy-tetrahydrodipicolinate synthase from Bifidobacterium longum subsp. longum JDM301
35% identity, 95% coverage

CPZ21_05260 4-hydroxy-tetrahydrodipicolinate synthase from Staphylococcus epidermidis
35% identity, 98% coverage

SERP_RS04835 4-hydroxy-tetrahydrodipicolinate synthase from Staphylococcus epidermidis RP62A
35% identity, 98% coverage

BL1193 dihydrodipicolinate synthase from Bifidobacterium longum NCC2705
BBMN68_956, PIB40_02760 4-hydroxy-tetrahydrodipicolinate synthase from Bifidobacterium longum subsp. longum BBMN68
35% identity, 95% coverage

Q42948 4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic from Nicotiana tabacum
35% identity, 79% coverage

B8DWI2 4-hydroxy-tetrahydrodipicolinate synthase from Bifidobacterium animalis subsp. lactis (strain AD011)
33% identity, 96% coverage

D7LRV3 4-hydroxy-tetrahydrodipicolinate synthase from Arabidopsis lyrata subsp. lyrata
37% identity, 76% coverage

IHV18_10020 4-hydroxy-tetrahydrodipicolinate synthase from Bifidobacterium breve
34% identity, 95% coverage

Q9LZX6 4-hydroxy-tetrahydrodipicolinate synthase 1, chloroplastic from Arabidopsis thaliana
NP_850730 dihydrodipicolinate synthase 1 from Arabidopsis thaliana
36% identity, 78% coverage

AT3G60880 dihydrodipicolinate synthase 1 (DHDPS1) (DHDPS) (DHPS1) from Arabidopsis thaliana
36% identity, 78% coverage

6vvhBBB / Q9LZX6 thaliana dihydrodipicolinate synthase isoform 1 (dhdps1) in complex with lysine (see paper)
36% identity, 91% coverage

dapA / CAA92211.1 dihydrodipicolinate synthase from Prochlorococcus marinus (see paper)
36% identity, 91% coverage

AWC34_RS13170 4-hydroxy-tetrahydrodipicolinate synthase from Staphylococcus equorum
32% identity, 96% coverage

Q9FVC8 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Arabidopsis thaliana (see paper)
NP_182068 dihydrodipicolinate synthase from Arabidopsis thaliana
AT2G45440 DHDPS2 (DIHYDRODIPICOLINATE SYNTHASE); catalytic/ dihydrodipicolinate synthase/ lyase from Arabidopsis thaliana
35% identity, 78% coverage

C9Z234 4-hydroxy-tetrahydrodipicolinate synthase from Streptomyces scabiei (strain 87.22)
35% identity, 92% coverage

D7LCJ3 4-hydroxy-tetrahydrodipicolinate synthase from Arabidopsis lyrata subsp. lyrata
35% identity, 78% coverage

4hnnF / D7U7T8 Dihydrodipicolinate synthase from the common grapevine with pyruvate and lysine (see paper)
34% identity, 89% coverage

PsgB076_08550 4-hydroxy-tetrahydrodipicolinate synthase from Pseudomonas savastanoi pv. glycinea str. B076
32% identity, 97% coverage

A0A438E022 4-hydroxy-tetrahydrodipicolinate synthase from Vitis vinifera
34% identity, 77% coverage

MAP2864c DapA_2 from Mycobacterium avium subsp. paratuberculosis str. k10
Q73VZ7 4-hydroxy-tetrahydrodipicolinate synthase from Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10)
34% identity, 96% coverage

D7U7T8 4-hydroxy-tetrahydrodipicolinate synthase from Vitis vinifera
34% identity, 78% coverage

DAPA_MYCTU / P9WP25 4-hydroxy-tetrahydrodipicolinate synthase; HTPA synthase; EC 4.3.3.7 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 3 papers)
Rv2753c dihydrodipicolinate synthase from Mycobacterium tuberculosis H37Rv
NP_217269 4-hydroxy-tetrahydrodipicolinate synthase from Mycobacterium tuberculosis H37Rv
37% identity, 79% coverage

5j5dA / P9WP25 Crystal structure of dihydrodipicolinate synthase from mycobacterium tuberculosis in complex with alpha-ketopimelic acid (see paper)
37% identity, 80% coverage

DIP1464 dihydrodipicolinate synthase from Corynebacterium diphtheriae NCTC 13129
35% identity, 77% coverage

MMAR_1962 dihydrodipicolinate synthase DapA from Mycobacterium marinum M
38% identity, 79% coverage

dapA / P19808 dihydropicolinate synthase subunit (EC 4.3.3.7) from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see paper)
P19808 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Corynebacterium glutamicum (see paper)
dapA / CAA79714.1 dihydrodipicolinate synthase from Corynebacterium glutamicum (see paper)
NCgl1896 4-hydroxy-tetrahydrodipicolinate synthase from Corynebacterium glutamicum ATCC 13032
35% identity, 95% coverage

B4FLW2 4-hydroxy-tetrahydrodipicolinate synthase from Zea mays
35% identity, 80% coverage

Q43038 4-hydroxy-tetrahydrodipicolinate synthase (Fragment) from Populus trichocarpa x Populus deltoides
34% identity, 72% coverage

P24846 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Triticum aestivum (see paper)
35% identity, 72% coverage

B8ARJ0 4-hydroxy-tetrahydrodipicolinate synthase from Oryza sativa subsp. indica
34% identity, 79% coverage

P26259 4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic from Zea mays
34% identity, 73% coverage

BPSL0346 dihydrodipicolinate synthetase family protein from Burkholderia pseudomallei K96243
33% identity, 92% coverage

P24847 4-hydroxy-tetrahydrodipicolinate synthase 2, chloroplastic from Triticum aestivum
34% identity, 74% coverage

YjhH / b4298 KpLE2 phage-like element; putative 2-dehydro-3-deoxy-D-pentonate aldolase (EC 4.1.2.28) from Escherichia coli K-12 substr. MG1655 (see 8 papers)
yjhH / P39359 KpLE2 phage-like element; putative 2-dehydro-3-deoxy-D-pentonate aldolase (EC 4.1.2.28) from Escherichia coli (strain K12) (see 7 papers)
YJHH_ECOLI / P39359 Probable 2-dehydro-3-deoxy-D-pentonate aldolase YjhH; EC 4.1.2.28 from Escherichia coli (strain K12) (see paper)
30% identity, 97% coverage

5ui3C Crystal structure of dhdps from chlamydomonas reinhardtii
33% identity, 90% coverage

Q9LWB9 4-hydroxy-tetrahydrodipicolinate synthase from Oryza sativa
34% identity, 80% coverage

Q81CD9 4-hydroxy-tetrahydrodipicolinate synthase from Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711)
30% identity, 79% coverage

PPA0642 dihydrodipicolinate synthase from Propionibacterium acnes KPA171202
32% identity, 99% coverage

HD73_3145 4-hydroxy-tetrahydrodipicolinate synthase from Bacillus thuringiensis serovar kurstaki str. HD73
30% identity, 79% coverage

VP1335 probable dihydrodipicolinate synthetase from Vibrio parahaemolyticus RIMD 2210633
28% identity, 95% coverage

MAB_3084c Dihydrodipicolinate synthase DapA from Mycobacterium abscessus ATCC 19977
31% identity, 98% coverage

ACS91_24330 dihydrodipicolinate synthase family protein from Vibrio parahaemolyticus
28% identity, 95% coverage

XAC2547 dihydrodipicolinate synthetase from Xanthomonas axonopodis pv. citri str. 306
28% identity, 96% coverage

EAM_RS12125 dihydrodipicolinate synthase family protein from Erwinia amylovora ATCC 49946
29% identity, 94% coverage

YagE / b0268 CP4-6 prophage; putative 2-dehydro-3-deoxygluconate aldolase (EC 4.1.2.28; EC 4.1.2.51) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
yagE / P75682 CP4-6 prophage; putative 2-dehydro-3-deoxygluconate aldolase (EC 4.1.2.28; EC 4.1.2.51) from Escherichia coli (strain K12) (see 8 papers)
YAGE_ECOLI / P75682 Putative 2-dehydro-3-deoxy-D-gluconate aldolase YagE; KDG aldolase YagE; Putative 2-dehydro-3-deoxy-D-pentonate aldolase YagE; EC 4.1.2.51; EC 4.1.2.28 from Escherichia coli (strain K12) (see 4 papers)
P75682 2-dehydro-3-deoxyglucarate aldolase (EC 4.1.2.20) from Escherichia coli (see paper)
31% identity, 78% coverage

3nevA / P75682 Crystal structure of yage, a prophage protein from e. Coli k12 in complex with kdgal (see paper)
31% identity, 80% coverage

b0268 CP4-6 prophage; predicted lyase/synthase from Escherichia coli str. K-12 substr. MG1655
31% identity, 77% coverage

DAPAL_RHIML / O69782 Uncharacterized DapA-like lyase; EC 4.-.-.- from Rhizobium meliloti (Ensifer meliloti) (Sinorhizobium meliloti) (see paper)
29% identity, 97% coverage

STM3532 putative dihydrodipicolinate synthetase from Salmonella typhimurium LT2
SL1344_3499 dihydrodipicolinate synthase family protein from Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344
28% identity, 96% coverage

KZA74_17400 dihydrodipicolinate synthase family protein from Acinetobacter baumannii
28% identity, 94% coverage

Bbr_1740 dihydrodipicolinate synthase family protein from Bifidobacterium breve
30% identity, 96% coverage

BLJ_1832 dihydrodipicolinate synthase family protein from Bifidobacterium longum subsp. longum JDM301
30% identity, 96% coverage

Q8NMD2 N-acetylneuraminate lyase (EC 4.1.3.3) from Corynebacterium glutamicum (see paper)
cg2931 N-acetylneuraminate lyase (aldolase) from Corynebacterium glutamicum ATCC 13032
28% identity, 90% coverage

5c55A / Q8NMD2 Crystal structure of the y138f mutant of c.Glutamicum n- acetylneuraminic acid lyase in complex with pyruvate
28% identity, 92% coverage

ArtHe_16635 dihydrodipicolinate synthase family protein from Arthrobacter sp. Helios
30% identity, 94% coverage

c0761 Putative dihydrodipicolinate synthase from Escherichia coli CFT073
32% identity, 87% coverage

PA14_48000 putative dihydrodipicolinate synthetase from Pseudomonas aeruginosa UCBPP-PA14
28% identity, 94% coverage

Blon_2338 dihydrodipicolinate synthetase from Bifidobacterium longum subsp. infantis ATCC 15697
29% identity, 96% coverage

PA1254 probable dihydrodipicolinate synthetase from Pseudomonas aeruginosa PAO1
28% identity, 94% coverage

Q6NY77 4-hydroxy-2-oxoglutarate aldolase, mitochondrial from Danio rerio
28% identity, 90% coverage

BOV_A0349 dihydrodipicolinate synthase family protein from Brucella ovis ATCC 25840
25% identity, 95% coverage

SSO3072 Dihydrodipicolinate synthase (dapA-3) from Sulfolobus solfataricus P2
31% identity, 75% coverage

SSO2274 Dihydrodipicolinate synthase (dapA-1) from Sulfolobus solfataricus P2
27% identity, 98% coverage

PSF113_2126 dihydrodipicolinate synthase family protein from Pseudomonas ogarae
26% identity, 93% coverage

rrnAC0960 dihydrodipicolinate synthase from Haloarcula marismortui ATCC 43049
31% identity, 88% coverage

BMEII0862 DIHYDRODIPICOLINATE SYNTHASE from Brucella melitensis 16M
25% identity, 90% coverage

8u8wA / A0A0H3FJT8 Crystal structure of n-acetylneuraminate lyase (nana) from klebsiella aerogenes (pyruvate and halides bound)
26% identity, 95% coverage

Varpa_5951 dihydrodipicolinate synthase family protein from Variovorax paradoxus EPS
29% identity, 95% coverage

Deide_3p01100 putative dihydrodipicolinate synthase from Deinococcus deserti VCD115
27% identity, 94% coverage

A9CFV4 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Agrobacterium tumefaciens (see paper)
25% identity, 93% coverage

BPSS0331 putative dihydrodipicolinate synthase from Burkholderia pseudomallei K96243
BMAA1420 dihydrodipicolinate synthetase family protein from Burkholderia mallei ATCC 23344
27% identity, 84% coverage

BKKJ1_2072 dihydrodipicolinate synthase family protein from Bifidobacterium catenulatum subsp. kashiwanohense
28% identity, 96% coverage

CD3000 putative dihydrodipicolinate synthase from Clostridium difficile 630
28% identity, 90% coverage

Q7D3Z9 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Agrobacterium tumefaciens (see paper)
32% identity, 70% coverage

DIP0511 Putative lysine biosynthesis protein from Corynebacterium diphtheriae NCTC 13129
24% identity, 94% coverage

Q9HWJ3 Dihydrodipicolinate synthase family protein from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
PA4188 hypothetical protein from Pseudomonas aeruginosa PAO1
25% identity, 92% coverage

3na8A / Q9I6R5 Crystal structure of a putative dihydrodipicolinate synthetase from pseudomonas aeruginosa
26% identity, 98% coverage

PA0223 probable dihydrodipicolinate synthetase from Pseudomonas aeruginosa PAO1
Q9I6R5 Probable dihydrodipicolinate synthetase from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
26% identity, 97% coverage

Npl / b3225 N-acetylneuraminate lyase (EC 4.1.3.3) from Escherichia coli K-12 substr. MG1655 (see 21 papers)
nanA / P0A6L4 N-acetylneuraminate lyase (EC 4.1.3.3) from Escherichia coli (strain K12) (see 30 papers)
NANA_ECOLI / P0A6L4 N-acetylneuraminate lyase; AcNeu lyase; NAL; Neu5Ac lyase; N-acetylneuraminate pyruvate-lyase; N-acetylneuraminic acid aldolase; NALase; Sialate lyase; Sialic acid aldolase; Sialic acid lyase; EC 4.1.3.3 from Escherichia coli (strain K12) (see 8 papers)
P0A6L4 N-acetylneuraminate lyase (EC 4.1.3.3) from Escherichia coli (see 4 papers)
nanA N-acetylneuraminate lyase; EC 4.1.3.3 from Escherichia coli K12 (see 6 papers)
NP_417692 N-acetylneuraminate lyase from Escherichia coli str. K-12 substr. MG1655
b3225 N-acetylneuraminate lyase from Escherichia coli str. K-12 substr. MG1655
S3478 N-acetylneuraminate lyase (aldolase) from Shigella flexneri 2a str. 2457T
Z4583 N-acetylneuraminate lyase (aldolase); catabolism of sialic acid; not K-12? from Escherichia coli O157:H7 EDL933
WP_000224714 N-acetylneuraminate lyase from Escherichia coli
28% identity, 81% coverage

2wpbA / P0A6L4 Crystal structure of the e192n mutant of e. Coli n-acetylneuraminic acid lyase in complex with pyruvate and the inhibitor (2r,3r)-2,3,4- trihydroxy-n,n-dipropylbutanamide in space group p21 crystal form i (see paper)
28% identity, 79% coverage

Afu8g02270 dihydrodipicolinate synthetase family protein from Aspergillus fumigatus Af293
31% identity, 69% coverage

c3979 N-acetylneuraminate lyase subunit from Escherichia coli CFT073
28% identity, 77% coverage

Q8A3Z0 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Bacteroides thetaiotaomicron (see paper)
BT_2814, BT_RS14270 dihydrodipicolinate synthase family protein from Bacteroides thetaiotaomicron VPI-5482
BT2814 dihydrodipicolinate synthase from Bacteroides thetaiotaomicron VPI-5482
25% identity, 94% coverage

ESA_03612 N-acetylneuraminate lyase from Cronobacter sakazakii ATCC BAA-894
25% identity, 94% coverage

IHMA87_00213 dihydrodipicolinate synthase family protein from Pseudomonas aeruginosa
25% identity, 97% coverage

RHE_RS03065 dihydrodipicolinate synthase family protein from Rhizobium etli CFN 42
25% identity, 95% coverage

t3256 N-acetylneuraminate lyase from Salmonella enterica subsp. enterica serovar Typhi Ty2
26% identity, 95% coverage

ESA_03612 hypothetical protein from Enterobacter sakazakii ATCC BAA-894
25% identity, 95% coverage

Deide_1p00310 putative dihydrodipicolinate synthase (DHDPS) from Deinococcus deserti VCD115
29% identity, 79% coverage

Cj0481 putative lyase from Campylobacter jejuni subsp. jejuni NCTC 11168
21% identity, 96% coverage

Q6KD26 N-acetylneuraminate lyase from Escherichia coli
25% identity, 90% coverage

PPA1998 dihydrodipicolinate synthase from Propionibacterium acnes KPA171202
24% identity, 95% coverage

PP_2036 dihydrodipicolinate synthase, putative from Pseudomonas putida KT2440
26% identity, 96% coverage

A911_02350 dihydrodipicolinate synthase family protein from Campylobacter jejuni subsp. jejuni PT14
21% identity, 96% coverage

BP3687 putative dihydrodipicolinate synthase from Bordetella pertussis Tohama I
27% identity, 98% coverage

BBA_06627 dihydrodipicolinate synthase from Beauveria bassiana ARSEF 2860
30% identity, 64% coverage

SSO3035 Dihydrodipicolinate synthase (dapA-2) from Sulfolobus solfataricus P2
30% identity, 66% coverage

Q7D0E8 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Agrobacterium tumefaciens (see paper)
Atu0899 dihydrodipicolinate synthase from Agrobacterium tumefaciens str. C58 (Cereon)
30% identity, 95% coverage

CH_124068 putative dihydrodipicolinate synthase from Magnaporthe grisea 70-15 (see paper)
30% identity, 64% coverage

PMI1233 dihydrodipicolinate synthase from Proteus mirabilis HI4320
28% identity, 95% coverage

BCAM2771 putative dihydrodipicolinate synthetase from Burkholderia cenocepacia J2315
26% identity, 93% coverage

HOGA1_BOVIN / Q0P5I5 4-hydroxy-2-oxoglutarate aldolase, mitochondrial; Dihydrodipicolinate synthase-like; DHDPS-like protein; Probable 2-keto-4-hydroxyglutarate aldolase; Probable KHG-aldolase; EC 4.1.3.16 from Bos taurus (Bovine) (see 2 papers)
Q0P5I5 4-Hydroxy-2-oxoglutarate aldolase (EC 4.1.3.16) from Bos taurus (see paper)
29% identity, 65% coverage

HOGA1 / Q86XE5 4-hydroxy-2-ketoglutarate aldolase subunit (EC 4.1.3.16) from Homo sapiens (see 6 papers)
HOGA1_HUMAN / Q86XE5 4-hydroxy-2-oxoglutarate aldolase, mitochondrial; Dihydrodipicolinate synthase-like; DHDPS-like protein; Probable 2-keto-4-hydroxyglutarate aldolase; Probable KHG-aldolase; Protein 569272; EC 4.1.3.16 from Homo sapiens (Human) (see 2 papers)
Q86XE5 4-Hydroxy-2-oxoglutarate aldolase (EC 4.1.3.16) from Homo sapiens (see 5 papers)
NP_612422 4-hydroxy-2-oxoglutarate aldolase, mitochondrial isoform 1 from Homo sapiens
28% identity, 65% coverage

HSERO_RS15785 5-dehydro-4-deoxyglucarate dehydratase (EC 4.2.1.41) from Herbaspirillum seropedicae SmR1
27% identity, 75% coverage

KDGA_PICTO / Q6KZI8 2-dehydro-3-deoxy-D-gluconate/2-dehydro-3-deoxy-phosphogluconate aldolase; 2-dehydro-3-deoxy-galactonate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase; EC 4.1.2.14; EC 4.1.2.51; EC 4.1.2.-; EC 4.1.2.21 from Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828 / KAW 2/3) (see paper)
Q6KZI8 2-dehydro-3-deoxy-D-gluconate aldolase (EC 4.1.2.51) from Picrophilus torridus (see paper)
26% identity, 69% coverage

kdgD / Q6FFQ1 5-dehydro-4-deoxyglucarate dehydratase subunit (EC 4.2.1.41) from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) (see paper)
KDGD_ACIAD / Q6FFQ1 Probable 5-dehydro-4-deoxyglucarate dehydratase; 5-keto-4-deoxy-glucarate dehydratase; KDGDH; EC 4.2.1.41 from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) (see paper)
Q6FFQ1 5-dehydro-4-deoxyglucarate dehydratase (EC 4.2.1.41) from Acinetobacter baylyi (see 2 papers)
ACIAD0130 5-dehydro-4-deoxyglucarate dehydratase (5-keto-4-deoxy-glucarate dehydratase) from Acinetobacter sp. ADP1
29% identity, 76% coverage

Q9DCU9 4-hydroxy-2-oxoglutarate aldolase, mitochondrial from Mus musculus
28% identity, 75% coverage

HF996_00605 N-acetylneuraminate lyase from Mycoplasma sp. 1654_15
26% identity, 72% coverage

Ta1157 dihydrodipicoline synthase related protein from Thermoplasma acidophilum DSM 1728
23% identity, 80% coverage

SSA_0078 / A3CK37 N-acetylneuraminate lyase subunit (EC 4.1.3.3) from Streptococcus sanguinis (strain SK36) (see 3 papers)
SSA_0078 N-acetylneuraminate lyase, putative from Streptococcus sanguinis SK36
24% identity, 93% coverage

SXYL_02665 dihydrodipicolinate synthase family protein from Staphylococcus xylosus
24% identity, 94% coverage

A1VMN2 5-dehydro-4-deoxyglucarate dehydratase (EC 4.2.1.41) from Polaromonas naphthalenivorans CJ2 (see paper)
31% identity, 58% coverage

CLP_0032 N-acetylneuraminate lyase from Clostridium butyricum E4 str. BoNT E BL5262
26% identity, 77% coverage

WP_005948757 N-acetylneuraminate lyase from Fusobacterium varium
26% identity, 77% coverage

Q27818 N-acetylneuraminate lyase from Trichomonas vaginalis
26% identity, 71% coverage

XP_001323296 dihydrodipicolinate synthase from Trichomonas vaginalis G3
26% identity, 71% coverage

D4A2K1 4-hydroxy-2-oxoglutarate aldolase, mitochondrial from Rattus norvegicus
27% identity, 88% coverage

CTL0615 dihydrodipicolinate synthase from Chlamydia trachomatis 434/Bu
28% identity, 91% coverage

Q1QUM4 Probable 5-dehydro-4-deoxyglucarate dehydratase from Chromohalobacter salexigens (strain ATCC BAA-138 / DSM 3043 / CIP 106854 / NCIMB 13768 / 1H11)
31% identity, 58% coverage

BCAM2512 putative 5-dehydro-4-deoxyglucarate dehydratase from Burkholderia cenocepacia J2315
26% identity, 75% coverage

Pf1N1B4_1110 5-dehydro-4-deoxyglucarate dehydratase (EC 4.2.1.41) from Pseudomonas fluorescens FW300-N1B4
27% identity, 93% coverage

B7WZA5 5-dehydro-4-deoxyglucarate dehydratase (EC 4.2.1.41) from Comamonas testosteroni (see paper)
29% identity, 61% coverage

RHE_RS14280 dihydrodipicolinate synthase family protein from Rhizobium etli CFN 42
30% identity, 75% coverage

HOGA1_EMENI / Q5BD77 Probable 4-hydroxy-2-oxoglutarate aldolase, mitochondrial; Dihydrodipicolinate synthase-like; DHDPS-like protein; Probable 2-keto-4-hydroxyglutarate aldolase; Probable KHG-aldolase; EC 4.1.3.16 from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) (see paper)
AN1503 dihydrodipicolinate synthase-like protein AN1503; EC 4.-.-.- from Emericella nidulans (see paper)
28% identity, 94% coverage

NANA_LACPL / P59407 N-acetylneuraminate lyase; NAL; Neu5Ac lyase; N-acetylneuraminate pyruvate-lyase; N-acetylneuraminic acid aldolase; Sialate lyase; Sialic acid aldolase; Sialic acid lyase; EC 4.1.3.3 from Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) (Lactobacillus plantarum) (see paper)
lp_3568 N-acetylneuraminate lyase from Lactobacillus plantarum WCFS1
27% identity, 76% coverage

SH0282 N-acetylneuraminate lyase subunit from Staphylococcus haemolyticus JCSC1435
27% identity, 78% coverage

Deide_3p00120 putative dihydrodipicolinate synthase from Deinococcus deserti VCD115
29% identity, 64% coverage

SCO6292 dihydropicolinate synthase from Streptomyces coelicolor A3(2)
26% identity, 96% coverage

nanA / Q9S4K9 N-acetylneuraminate lyase (EC 4.1.3.3) from Clostridium perfringens (strain 13 / Type A) (see 6 papers)
NANA_CLOPE / Q9S4K9 N-acetylneuraminate lyase; NAL; Neu5Ac lyase; N-acetylneuraminate pyruvate-lyase; N-acetylneuraminic acid aldolase; Sialate lyase; Sialic acid aldolase; Sialic acid lyase; EC 4.1.3.3 from Clostridium perfringens (strain 13 / Type A) (see 3 papers)
nanA / GB|CAA73375.1 N-acetylneuraminate lyase; EC 4.1.3.3 from Clostridium perfringens (see 4 papers)
CPE0185 acylneuraminate lyase from Clostridium perfringens str. 13
CPF_0178 N-acetylneuraminate lyase from Clostridium perfringens ATCC 13124
25% identity, 76% coverage

WP_002480218 N-acetylneuraminate lyase from Staphylococcus simulans
27% identity, 78% coverage

4woqC / D5Q364 Crystal structures of cdnal from clostridium difficile in complex with ketobutyric
24% identity, 94% coverage

nanA sialic acid lyase from Clostridium perfringens (see paper)
25% identity, 76% coverage

CD2240 N-acetylneuraminate lyase from Clostridium difficile 630
24% identity, 94% coverage

NANA_PASMU / Q9CKB0 N-acetylneuraminate lyase; NAL; Neu5Ac lyase; N-acetyl-D-neuraminic acid lyase; N-acetylneuraminate pyruvate-lyase; N-acetylneuraminic acid aldolase; Sialate lyase; Sialic acid aldolase; Sialic acid lyase; EC 4.1.3.3 from Pasteurella multocida (strain Pm70) (see paper)
Q9CKB0 N-acetylneuraminate lyase (EC 4.1.3.3) from Pasteurella multocida (see 2 papers)
PM1715 NanA from Pasteurella multocida subsp. multocida str. Pm70
26% identity, 77% coverage

C9PLY8 N-acetylneuraminate lyase from Pasteurella dagmatis ATCC 43325
26% identity, 77% coverage

ACICU_00871 dihydrodipicolinate synthase/N-acetylneuraminate lyase from Acinetobacter baumannii ACICU
ACICU_RS04560 dihydrodipicolinate synthase family protein from Acinetobacter baumannii ACICU
25% identity, 90% coverage

A1S_0203 hypothetical protein from Acinetobacter baumannii ATCC 17978
27% identity, 71% coverage

NANA_HAEIN / P44539 N-acetylneuraminate lyase; NAL; Neu5Ac lyase; N-acetylneuraminate pyruvate-lyase; N-acetylneuraminic acid aldolase; Sialate lyase; Sialic acid aldolase; Sialic acid lyase; EC 4.1.3.3 from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) (see 2 papers)
HI0142 N-acetylneuraminate lyase (nanA) from Haemophilus influenzae Rd KW20
26% identity, 79% coverage

C8P490 N-acetylneuraminate lyase (EC 4.1.3.3) from Limosilactobacillus antri (see paper)
22% identity, 93% coverage

NANA_STAA8 / Q2G160 N-acetylneuraminate lyase; NAL; Neu5Ac lyase; N-acetylneuraminate pyruvate-lyase; N-acetylneuraminic acid aldolase; Sialate lyase; Sialic acid aldolase; Sialic acid lyase; EC 4.1.3.3 from Staphylococcus aureus (strain NCTC 8325 / PS 47) (see 4 papers)
NANA_STAAR / Q6GK01 N-acetylneuraminate lyase; NAL; Neu5Ac lyase; N-acetylneuraminate pyruvate-lyase; N-acetylneuraminic acid aldolase; Sialate lyase; Sialic acid aldolase; Sialic acid lyase; EC 4.1.3.3 from Staphylococcus aureus (strain MRSA252) (see paper)
Q2G160 N-acetylneuraminate lyase (EC 4.1.3.3) from Staphylococcus aureus (see 2 papers)
Q6GK01 N-acetylneuraminate lyase (EC 4.1.3.3) from Staphylococcus aureus (see paper)
MW0292 N-acetylneuraminate lyase subunit from Staphylococcus aureus subsp. aureus MW2
SAOUHSC_00295 N-acetylneuraminate lyase subunit, putative from Staphylococcus aureus subsp. aureus NCTC 8325
SAUSA300_0315 N-acetylneuraminate lyase subunit from Staphylococcus aureus subsp. aureus USA300_FPR3757
SACOL0312 N-acetylneuraminate lyase from Staphylococcus aureus subsp. aureus COL
YP_498885 N-acetylneuraminate lyase from Staphylococcus aureus subsp. aureus NCTC 8325
26% identity, 77% coverage

NANA_FUSNN / Q8RDN6 N-acetylneuraminate lyase; NAL; Neu5Ac lyase; N-acetylneuraminate pyruvate-lyase; N-acetylneuraminic acid aldolase; Sialate lyase; Sialic acid aldolase; Sialic acid lyase; EC 4.1.3.3 from Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355) (see paper)
25% identity, 77% coverage

SA0304 N-acetylneuraminate lyase from Staphylococcus aureus subsp. aureus N315
SAV0315 N-acetylneuraminate lyase from Staphylococcus aureus subsp. aureus Mu50
26% identity, 77% coverage

BPHYT_RS24155 5-dehydro-4-deoxyglucarate dehydratase (EC 4.2.1.41) from Burkholderia phytofirmans PsJN
26% identity, 92% coverage

PFLU0849 5-dehydro-4-deoxyglucarate dehydratase from Pseudomonas fluorescens SBW25
29% identity, 58% coverage

NANA_MEDG7 / A7B555 N-acetylneuraminate lyase; NAL; Neu5Ac lyase; N-acetylneuraminate pyruvate-lyase; N-acetylneuraminic acid aldolase; Sialate lyase; Sialic acid aldolase; Sialic acid lyase; EC 4.1.3.3 from Mediterraneibacter gnavus (strain ATCC 29149 / DSM 114966 / JCM 6515 / VPI C7-9) (Ruminococcus gnavus) (see paper)
RUMGNA_02692 hypothetical protein from Ruminococcus gnavus ATCC 29149
22% identity, 90% coverage

B9DIJ2 N-acetylneuraminate lyase (EC 4.1.3.3) from Staphylococcus carnosus (see paper)
26% identity, 97% coverage

SCO2543 5-dehydro-4-deoxyglucarate dehydratase from Streptomyces coelicolor A3(2)
29% identity, 55% coverage

1f74A / P44539 Crystal structure analysis of n-acetylneuraminate lyase from haemophilus influenzae: crystal form ii complexed with 4-deoxy-sialic acid (see paper)
26% identity, 79% coverage

4imgA / Q9CKB0 Crystal structure of pasteurella multocida n-acetyl-d-neuraminic acid lyase k164 mutant complexed with n-glycolylneuraminic acid (see paper)
25% identity, 97% coverage

SP_1676 N-acetylneuraminate lyase, putative from Streptococcus pneumoniae TIGR4
22% identity, 93% coverage

A4N656 N-acetylneuraminate lyase from Haemophilus influenzae R3021
26% identity, 77% coverage

PS417_04195 5-dehydro-4-deoxyglucarate dehydratase (EC 4.2.1.41) from Pseudomonas simiae WCS417
PS417_04195 5-dehydro-4-deoxyglucarate dehydratase from Pseudomonas simiae
29% identity, 58% coverage

PAAG_03793 dihydrodipicolinate synthase from Paracoccidioides lutzii Pb01
27% identity, 66% coverage

6rb7A / A7B555 Ruminococcus gnavus sialic acid aldolase catalytic lysine mutant (see paper)
22% identity, 93% coverage

PP_3599 5-dehydro-4-deoxyglucarate dehydratase (EC 4.2.1.41) from Pseudomonas putida KT2440
26% identity, 76% coverage

New Search

For advice on how to use these tools together, see Interactive tools for functional annotation of bacterial genomes.

Statistics

The PaperBLAST database links 784,739 different protein sequences to 1,253,012 scientific articles. Searches against EuropePMC were last performed on November 25 2024.

How It Works

PaperBLAST builds a database of protein sequences that are linked to scientific articles. These links come from automated text searches against the articles in EuropePMC and from manually-curated information from GeneRIF, UniProtKB/Swiss-Prot, BRENDA, CAZy (as made available by dbCAN), BioLiP, CharProtDB, MetaCyc, EcoCyc, TCDB, REBASE, the Fitness Browser, and a subset of the European Nucleotide Archive with the /experiment tag. Given this database and a protein sequence query, PaperBLAST uses protein-protein BLAST to find similar sequences with E < 0.001.

To build the database, we query EuropePMC with locus tags, with RefSeq protein identifiers, and with UniProt accessions. We obtain the locus tags from RefSeq or from MicrobesOnline. We use queries of the form "locus_tag AND genus_name" to try to ensure that the paper is actually discussing that gene. Because EuropePMC indexes most recent biomedical papers, even if they are not open access, some of the links may be to papers that you cannot read or that our computers cannot read. We query each of these identifiers that appears in the open access part of EuropePMC, as well as every locus tag that appears in the 500 most-referenced genomes, so that a gene may appear in the PaperBLAST results even though none of the papers that mention it are open access. We also incorporate text-mined links from EuropePMC that link open access articles to UniProt or RefSeq identifiers. (This yields some additional links because EuropePMC uses different heuristics for their text mining than we do.)

For every article that mentions a locus tag, a RefSeq protein identifier, or a UniProt accession, we try to select one or two snippets of text that refer to the protein. If we cannot get access to the full text, we try to select a snippet from the abstract, but unfortunately, unique identifiers such as locus tags are rarely provided in abstracts.

PaperBLAST also incorporates manually-curated protein functions:

Except for GeneRIF and ENA, the curated entries include a short curated description of the protein's function. For entries from BioLiP, the protein's function may not be known beyond binding to the ligand. Many of these entries also link to articles in PubMed.

For more information see the PaperBLAST paper (mSystems 2017) or the code. You can download PaperBLAST's database here.

Changes to PaperBLAST since the paper was written:

Many of these changes are described in Interactive tools for functional annotation of bacterial genomes.

Secrets

PaperBLAST cannot provide snippets for many of the papers that are published in non-open-access journals. This limitation applies even if the paper is marked as "free" on the publisher's web site and is available in PubmedCentral or EuropePMC. If a journal that you publish in is marked as "secret," please consider publishing elsewhere.

Omissions from the PaperBLAST Database

Many important articles are missing from PaperBLAST, either because the article's full text is not in EuropePMC (as for many older articles), or because the paper does not mention a protein identifier such as a locus tag, or because of PaperBLAST's heuristics. If you notice an article that characterizes a protein's function but is missing from PaperBLAST, please notify the curators at UniProt or add an entry to GeneRIF. Entries in either of these databases will eventually be incorporated into PaperBLAST. Note that to add an entry to UniProt, you will need to find the UniProt identifier for the protein. If the protein is not already in UniProt, you can ask them to create an entry. To add an entry to GeneRIF, you will need an NCBI Gene identifier, but unfortunately many prokaryotic proteins in RefSeq do not have corresponding Gene identifers.

References

PaperBLAST: Text-mining papers for information about homologs.
M. N. Price and A. P. Arkin (2017). mSystems, 10.1128/mSystems.00039-17.

Europe PMC in 2017.
M. Levchenko et al (2017). Nucleic Acids Research, 10.1093/nar/gkx1005.

Gene indexing: characterization and analysis of NLM's GeneRIFs.
J. A. Mitchell et al (2003). AMIA Annu Symp Proc 2003:460-464.

UniProt: the universal protein knowledgebase.
The UniProt Consortium (2016). Nucleic Acids Research, 10.1093/nar/gkw1099.

BRENDA in 2017: new perspectives and new tools in BRENDA.
S. Placzek et al (2017). Nucleic Acids Research, 10.1093/nar/gkw952.

The EcoCyc database: reflecting new knowledge about Escherichia coli K-12.
I. M. Keeseler et al (2016). Nucleic Acids Research, 10.1093/nar/gkw1003.

The MetaCyc database of metabolic pathways and enzymes.
R. Caspi et al (2018). Nucleic Acids Research, 10.1093/nar/gkx935.

CharProtDB: a database of experimentally characterized protein annotations.
R. Madupu et al (2012). Nucleic Acids Research, 10.1093/nar/gkr1133.

The carbohydrate-active enzymes database (CAZy) in 2013.
V. Lombard et al (2014). Nucleic Acids Research, 10.1093/nar/gkt1178.

The Transporter Classification Database (TCDB): recent advances
M. H. Saier, Jr. et al (2016). Nucleic Acids Research, 10.1093/nar/gkv1103.

REBASE - a database for DNA restriction and modification: enzymes, genes and genomes.
R. J. Roberts et al (2015). Nucleic Acids Research, 10.1093/nar/gku1046.

Deep annotation of protein function across diverse bacteria from mutant phenotypes.
M. N. Price et al (2016). bioRxiv, 10.1101/072470.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory