PaperBLAST
PaperBLAST Hits for BRENDA::Q6GIL6 triose-phosphate isomerase (EC 5.3.1.1) (Staphylococcus aureus) (253 a.a., MRTPIIAGNW...)
Show query sequence
>BRENDA::Q6GIL6 triose-phosphate isomerase (EC 5.3.1.1) (Staphylococcus aureus)
MRTPIIAGNWKMNKTVQEAKDFVNALPTLPDSKEVESVICAPAIQLDALTTAVKEGKAQG
LEIGAQNTYFEDNGAFTGETSPVALADLGVKYVVIGHSERRELFHETDEEINKKAHAIFK
HGMTPIICVGETDEERESGKANDVVGEQVKKAVAGLSEDQLKSVVIAYEPIWAIGTGKSS
TSEDANEMCAFVRQTIADLSSKEVSEATRIQYGGSVKPNNIKEYMAQTDIDGALVGGASL
KVEDFVQLLEGAK
Running BLASTp...
Found 250 similar proteins in the literature:
3uwvA / Q6GIL6 Crystal structure of staphylococcus aureus triosephosphate isomerase complexed with 2-phosphoglyceric acid (see paper)
100% identity, 99% coverage
- Ligand: 2-phosphoglyceric acid (3uwvA)
TPIS_STAAR / Q6GIL6 Triosephosphate isomerase; TIM; TPI; Triose-phosphate isomerase; EC 5.3.1.1 from Staphylococcus aureus (strain MRSA252) (see 3 papers)
Q6GIL6 triose-phosphate isomerase (EC 5.3.1.1) from Staphylococcus aureus (see paper)
P68824 Triosephosphate isomerase from Staphylococcus aureus (strain MW2)
A7WZS8 Triosephosphate isomerase from Staphylococcus aureus (strain Mu3 / ATCC 700698)
P99133 Triosephosphate isomerase from Staphylococcus aureus (strain N315)
Q2FIL9 Triosephosphate isomerase from Staphylococcus aureus (strain USA300)
SA0729 triosephosphate isomerase from Staphylococcus aureus subsp. aureus N315
NP_371298 triosephosphate isomerase from Staphylococcus aureus subsp. aureus Mu50
SAUSA300_0758 triosephosphate isomerase from Staphylococcus aureus subsp. aureus USA300_FPR3757
NWMN_0743 triosephosphate isomerase from Staphylococcus aureus subsp. aureus str. Newman
SAR0830 triosephosphate isomerase from Staphylococcus aureus subsp. aureus MRSA252
SACOL0840 triosephosphate isomerase from Staphylococcus aureus subsp. aureus COL
CH51_RS04255, E5491_RS04085, RDJ18_RS04315, SAOV_0816 triose-phosphate isomerase from Staphylococcus aureus
100% identity, 100% coverage
- function: Involved in biofilm formation (PubMed:11425708). It also plays an instrumental role in adherence and invasion of the bacteria into the host cell (PubMed:22003920). Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3- phosphate (G3P). It binds plasminogen.
catalytic activity: D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate (RHEA:18585)
subunit: Homodimer. - Comparative secretome analysis of Staphylococcus aureus strains with different within-herd intramammary infection prevalence
Addis, Virulence 2022 - “...6.64 Unknown/undefined A0A7H4FTU9 Zinc metalloproteinase aureolysin 6.64 Pathogenesis/Protease Proteins significantly more abundant in GTB/ST8 secretomes P68824 Triosephosphate isomerase 6.49 Carbohydrate metabolism A0A7H2IWP3 50S ribosomal protein L24 6.14 Ribosome A0A6B5M3E9 Fructose-bisphosphate aldolase class 1 5.62 Carbohydrate metabolism A0A6L0II03 Immunoglobulin G binding protein A 4.54 Pathogenesis /Immune evasion...”
- Influence of tryptophan contained in 1-Methyl-Tryptophan on antimicrobial and immunoregulatory functions of indoleamine 2,3-dioxygenase
Schmidt, PloS one 2012 - “...(B). From the spectra shown, the peptide SVVIAYEPIWAIGTGK from S. aureus Triosephosphate isomerase (Uniprot ID: A7WZS8) was identified with a mascot score of 63 (L-tryptophan) and 47 (1-L-MT). The peptide contains L-Tryptophan and not 1-L-MT in both samples. Fragment ions identifying the tryptophan residue are clearly...”
- Impacts of the Type I Toxin-Antitoxin System, SprG1/SprF1, on Staphylococcus aureus Gene Expression
Chlebicka, Genes 2021 - “...1.66 1.60 13 Fructose-bisphosphate aldolase class 1 (Fda) P99117 1.68 1.56 14 Triosephosphate isomerase (TpiA) P99133 1.59 1.92 15 Glyceraldehyde-3-phosphate dehydrogenase 1 (GapA1) P99136 1.5 16 3-hexulose-6-phosphate synthase (HPS) Q7A774 1.92 2.11 17 Formate--tetrahydrofolate ligase (FHS) Q7A535 3.41 2.75 18 Phosphoenolpyruvate-protein phosphotransferase (PtsI) Q99V14 1.63 19...”
- The Spl Serine Proteases Modulate Staphylococcus aureus Protein Production and Virulence in a Rabbit Model of Pneumonia
Paharik, mSphere 2016 - “...Q2FIB3 ( G6PI_STAA3 ) Glucose-6-phosphate isomerase Pgi Metabolism, carbohydrate metabolism, glycolysis, gluconeogenesis 45.33 71.67 0.000014 Q2FIL9 ( TPIS_STAA3 ) Triosephosphate isomerase TpiA Metabolism, carbohydrate metabolism, glycolysis, gluconeogenesis 27.00 52.00 0.00000063 Q2FE81 ( GPMA_STAA3 ) 2,3-Bisphosphoglycerate-dependent phosphoglycerate mutase GmpA Metabolism, carbohydrate metabolism, glycolysis, gluconeogenesis 13.33 33.67 0.00000014...”
- Structural and Functional Dynamics of Staphylococcus aureus Biofilms and Biofilm Matrix Proteins on Different Clinical Materials
Hiltunen, Microorganisms 2019 - “...Q6GIL7 Pyruvate kinasePYK Q6GG09 Fructose-bisphosphate aldolase class 1FBA Q6GDJ7 Pyruvate dehydrogenase E1PDHB Q6GHZ1 Triosephosphate isomeraseTPI Q6GIL6 ATP-dependent 6-phosphofructokinasePFK Q6GG08 2,3-phosphoglycerate mutasePPGM Q6GE17 Aconitase AAcnA Q6GH55 L-lactate dehydrogenase 1L-LDH Q6GK73 D-lactate dehydrogenaseD-LDH Q6GDS2 Alkaline shock protein 23Asp23 Q6GEP7 Alcohol dehydrogenaseADH Q99W07 Trigger factorTf Q6GG30 DNA-directed RNA polymeraseRpoB...”
- Secretome analysis revealed adaptive and non-adaptive responses of the Staphylococcus carnosus femB mutant
Nega, Proteomics 2015 - “...Tkt Putative transketolase Sca_0983 SA1177 tkt SACOL1377 3 72.8 5.0 TpiA Triosephosphate isomerase homolog Sca_0426 SA0729 tpi SACOL0840 4.7 27.5 4.8 UreC UreC urease alpha subunit homolog Sca_1782 SA2084 ureC SACOL2282 3.9 62.4 5.3 Sca0081 Putative intracellular protease/amidase Sca_0081 6.8 25.7 6.7 Sca0559 Putative peptidyl-prolyl cis-trans...”
- Biofilm matrix exoproteins induce a protective immune response against Staphylococcus aureus biofilm infection
Gil, Infection and immunity 2014 - “...Non-differentially expressed exoproteins 15926452c SA0730 15926451c SA0729 c 15926453 15923272c 15926190c 15926073c SA0731 SA0271 SA0471 SA0359 15928230c SA2437...”
- Growth-dependent release of carbohydrate metabolism-related and antioxidant enzymes from Staphylococcus aureus strain 6 as determined by proteomic analysis
Donenko, Experimental and therapeutic medicine 2011 - “...sodA SA1382 10 F89963 SA1599 SA1599 11 G89850 tpiA SA0729 Fructose bisphosphate 32907 4.69 788 25 aldolase class 1 Glycine cleavage 14072 3.70 140 2 system H...”
- Eukaryote-like serine/threonine kinases and phosphatases in bacteria
Pereira, Microbiology and molecular biology reviews : MMBR 2011 - “...regulator; toxin expression CovR SA1499 SA2340 SA2399 SA1359 SA0729 SA0731 SA0944 NA Ser(s), Thr(s) Thr(s) Thr(s) NA Thr(s) NA Thr(s) NA Thr(s) Ser(s) NA...”
- Characterizing the effect of the Staphylococcus aureus virulence factor regulator, SarA, on log-phase mRNA half-lives
Roberts, Journal of bacteriology 2006 - “...15 5 5 5 5 SA0934 SA0729 SA0528 SA2053 Enolase Fructose-bisphosphate aldolase Fructose-bisphosphate aldolase homolog Glyceraldehyde-3-phosphate dehydrogenase...”
- Reporter metabolite analysis of transcriptional profiles of a Staphylococcus aureus strain with normal phenotype and its isogenic hemB mutant displaying the small-colony-variant phenotype
Seggewiss, Journal of bacteriology 2006 - “...SA1245 SA2008 SA0730 SA1184 SA1244 SA1141 SA0728 SA2007 SA0729 SA0182 SA1553 SA1089 SA2327 SA1554 SA0232 SA0219 Description 7770 J. BACTERIOL. SEGGEWI ET AL....”
- Blood Serum Affects Polysaccharide Production and Surface Protein Expression in S. Aureus
Islam, Advances in biotechnology & microbiology (Newbury, Calif.) 2017 - “...2. 50s ribosomal protein Expression of mRNA 9_5/24 NP_371062 b10 1. Triosephosphate isomerase Glycolysis 4.7125 NP_371298 2. Purine nucleoside phosphorylase Purine metabolism 43/26 NP_372662 3. Deoxyribose-phosphate aldolase Pentose phosphate pathway 4.5/23 NP_370662 4_Phosphoribosylaminoimidazole-succinocarboxamide synthase Purine metabolism 5.2/26 NP_371590 5. Putative translaldolase Carbohydrate metabolism 5.6/26 NP_6465,38 6....”
- Human Urine Alters Methicillin-Resistant Staphylococcus aureus Virulence and Transcriptome
Paudel, Applied and environmental microbiology 2021 (secret) - Heparin Mimics Extracellular DNA in Binding to Cell Surface-Localized Proteins and Promoting Staphylococcus aureus Biofilm Formation
Mishra, mSphere 2017 - “...SAUSA300_1239 Transketolase 9 9 21 None SAUSA300_0539 Branched-chain amino acid transferase 8 11 23 None SAUSA300_0758 Triose phosphate isomerase 11 20 56 None SAUSA300_1666 30S ribosomal protein S4 4 6 25 ARTRRQ SAUSA300_0871 Fumarylacetoacetate hydrolase 7 7 35 None SAUSA300_0886 3-Oxoacyl-synthase 2 8 10 33 None...”
- Proteomic Identification of saeRS-Dependent Targets Critical for Protective Humoral Immunity against Staphylococcus aureus Skin Infection
Zhao, Infection and immunity 2015 - “...SAUSA300_0883 SAUSA300_0395 SAUSA300_2366 SAUSA300_1058 SAUSA300_0758 SAUSA300_2441 SAUSA300_0552 SAUSA300_0231 SAUSA300_0207 IgG-binding protein Sbi Putative...”
- Staphylococcus aureus fur regulates the expression of virulence factors that contribute to the pathogenesis of pneumonia
Torres, Infection and immunity 2010 - “...18 11 26 2.74 4.53 2.73 3.00 0.001 7.30E05 6.10E04 1.40E03 NWMN_0743 NWMN_0634 27.4 28.2 4.8 6.1 71 46 5 (1) 3 (2) 3 1 23 14 2.25 1.71 9.70E05 0.00071 NWMN_0400...”
- Expression, purification, crystallization and preliminary X-ray diffraction studies of triosephosphate isomerase from methicillin-resistant Staphylococcus aureus (MRSA252)
Mukherjee, Acta crystallographica. Section F, Structural biology and crystallization communications 2009 - “...aureus MRSA252 possesses a single triosephosphate isomerase (SaTIM; SAR0830) comprised of 253 amino acids. SaTIM is one of the components of the cell-envelope...”
- The Staphylococcus aureus response to unsaturated long chain free fatty acids: survival mechanisms and virulence implications
Kenny, PloS one 2009 - “...4.80E-03 SAR0776 Osmoprotectant ABC transporter, permease protein 2.99 3.00E-04 SAR0824 putative malolactic enzyme 2.59 9.27E-03 SAR0830 tpiA triosephosphate isomerase 2.22 3.39E-02 SAR0831 pgm putative phosphoglycerate mutase 2.64 1.39E-02 SAR1017 menD putative menaquinone biosynthesis bifunctional protein 2.24 1.65E-03 SAR1018 putative hydrolase 2.80 1.65E-03 SAR2386 putative NAD-dependent dehydrogenase...”
- “...glcA glucose-specific PTS transporter protein, IIABC component 2.05 3.76E-02 SAR0829 pgk phosphoglycerate kinase 2.76 2.16E-03 SAR0830 tpiA triosephosphate isomerase 2.75 1.69E-03 SAR0831 pgm putative phosphoglycerate mutase 2.83 2.22E-03 SAR0832 eno putative enolase 2.15 5.88E-03 SAR2296 alsD putative acetolactate decarboxylase 2.43 3.32E-03 SAR2297 alsS putative acetolactate synthase...”
- Diamide triggers mainly S Thiolations in the cytoplasmic proteomes of Bacillus subtilis and Staphylococcus aureus
Pöther, Journal of bacteriology 2009 - “...pyruvate kinase (SAR1776) at C8, a triosephosphate isomerase (SAR0830) at C-40, and SarA (SAR0625) at C-9. Because all modified proteins were identified from...”
- Secretome analysis revealed adaptive and non-adaptive responses of the Staphylococcus carnosus femB mutant
Nega, Proteomics 2015 - “...transketolase Sca_0983 SA1177 tkt SACOL1377 3 72.8 5.0 TpiA Triosephosphate isomerase homolog Sca_0426 SA0729 tpi SACOL0840 4.7 27.5 4.8 UreC UreC urease alpha subunit homolog Sca_1782 SA2084 ureC SACOL2282 3.9 62.4 5.3 Sca0081 Putative intracellular protease/amidase Sca_0081 6.8 25.7 6.7 Sca0559 Putative peptidyl-prolyl cis-trans isomerase Sca_0559...”
- Nitric oxide stress induces different responses but mediates comparable protein thiol protection in Bacillus subtilis and Staphylococcus aureus
Hochgräfe, Journal of bacteriology 2008 - “...Energy metabolism SACOL0204 SACOL0222 SACOL0837 SACOL0838 SACOL0839 SACOL0840 SACOL0841 PflB Ldh1 GapR GapA1 Pgk TpiA Pgm 57285406 57286685 57284299 57284300...”
- New Insights into the Biological Functions of Essential TsaB/YeaZ Protein in Staphylococcus aureus
Guo, Antibiotics (Basel, Switzerland) 2024 - “...also significantly interact with YeaZ/TsaB, which could serve as a potential hub gene. The TPI (E5491_RS04085, triose-phosphate isomerase) gene is directly involved in the pathways including ko01200 carbon metabolism, ko01230 biosynthesis of amino acids, ko00010 glycolysis/gluconeogenesis, ko00051 fructose and mannose metabolism, ko00562 Inositol phosphate metabolism, ko00710...”
- “...with TsaB/YeaZ in S. aureus . Gene Name Gene orf Number Degree Profile Type tpi E5491_RS04085 9 3 down-down thrB E5491_RS06900 6 0 down-down leuC E5491_RS11545 5 0 down-down dapH E5491_RS07270 4 0 down-down tsaB/yeaZ E5491_RS11500 4 groEL E5491_RS11380 4 2 down-down yidC E5491_RS11755 4 13...”
- Multiomics analysis of Staphylococcus aureus ST239 strains resistant to virulent Herelleviridae phages
Kornienko, Scientific reports 2024 - “...in glycolysis exhibited upregulation: pyruvate kinase (RDJ18_RS06570), L-lactate dehydrogenase (RDJ18_RS01065), phosphoglycerate kinase (RDJ18_RS04310), triose-phosphate isomerase (RDJ18_RS04315), and 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (RDJ18_RS04320). However, glyceraldehyde-3-phosphate dehydrogenase (RDJ18_RS06625) and 2,3-diphosphoglycerate-dependent phosphoglycerate mutase (RDJ18_RS12880) were downregulated. The former catalyzes the conversion of glyceraldehyde-3-phosphate to 1,3-diphosphoglycerate, while the latter catalyzes the...”
- Staphylococcus aureus PhoU Homologs Regulate Persister Formation and Virulence
Shang, Frontiers in microbiology 2020 - “...change RNA-seq qRT-PCR Carbon metabolism CH51_RS04260 2,3-Bisphosphoglycerate-independent phosphoglycerate mutase 0.42 ND CH51_RS04265 Enolase 0.49 ND CH51_RS04255 Triose-phosphate isomerase 0.42 ND CH51_RS02745 Cysteine synthase 0.31 ND CH51_RS04250 Phosphoglycerate kinase 0.36 ND CH51_RS14740 Malate:quinone oxidoreductase 0.49 ND CH51_RS04245 Aldehyde dehydrogenase 0.34 ND Pyruvate metabolism CH51_RS14295 D-Lactate dehydrogenase 3.11...”
- Staphylococcus aureus seroproteomes discriminate ruminant isolates causing mild or severe mastitis
Le, Veterinary research 2011 - “...SAOV_1765 4,72 25689 554,11 46,84 10 3,32 S C tpiA triosephosphate isomerase 9 011_2338 046_2239 SAOV_0816 4,81 27271 1396,16 76,28 21 16,78 S C [ 4 , 91 , 92 ] atl autolysin 23, 31 011_1991 046_0320 SAOV_0999c 9,59 136983 2567,68 42,14 42 1,87 S S...”
SAOUHSC_00797 triosephosphate isomerase from Staphylococcus aureus subsp. aureus NCTC 8325
100% identity, 100% coverage
WP_029377651 triose-phosphate isomerase from Staphylococcus xylosus
89% identity, 100% coverage
- Proteome Response of Staphylococcus xylosus DSM 20266T to Anaerobiosis and Nitrite Exposure
Quintieri, Frontiers in microbiology 2018 - “...Accession a Functional classification b Protein annotation Symbol Fold changes ANitrite/A ANA/A ANANitrite/A ANANitrite/ANA 45 WP_029377651 Glycolysis/Gluconeogenesis Triosephosphate isomerase TpiA 1.18 2.04 1.66 0.81 77 AID01643.1 Glycolysis Glyceraldehyde-3-phosphate dehydrogenase Gap 1.05 0.50 0.50 0.96 94 WP_029377652 Glycolysis Phosphoglycerate kinase Pgk 1.25 2.64 3.22 1.22 127 WP_029377650...”
SERP0444 triosephosphate isomerase from Staphylococcus epidermidis RP62A
Q5HQV2 Triosephosphate isomerase from Staphylococcus epidermidis (strain ATCC 35984 / DSM 28319 / BCRC 17069 / CCUG 31568 / BM 3577 / RP62A)
88% identity, 100% coverage
Sca_0426 triosephosphate isomerase from Staphylococcus carnosus subsp. carnosus TM300
82% identity, 100% coverage
UH47_11070 triose-phosphate isomerase from Staphylococcus pseudintermedius
80% identity, 100% coverage
BSU33920 triosephosphate isomerase from Bacillus subtilis subsp. subtilis str. 168
P27876 Triosephosphate isomerase from Bacillus subtilis (strain 168)
66% identity, 99% coverage
- The Blueprint of a Minimal Cell: MiniBacillus
Reuß, Microbiology and molecular biology reviews : MMBR 2016 - “...Yes No No No No BSU13890 BSU13900 BSU13910 BSU31350 BSU29190 BSU37120 BSU33920 BSU33940 No No No No No No No Yes Yes Yes Yes Yes Yes pgk BSU33930 pgm eno pyk...”
- In Silico Safety Assessment of <i>Bacillus</i> Isolated from Polish Bee Pollen and Bee Bread as Novel Probiotic Candidates
Bin, International journal of molecular sciences 2024 - “...spo0A Stage 0 sporulation protein A P06534 Tuf Elongation factor Tu P33166 tpiA Triosephosphate isomerase P27876 gapA Glyceraldehyde-3-phosphate dehydrogenase 1 P09124 ganA Beta-galactosidase GanA O07012 srtD Sortase D P54603 mdxK Maltose phosphorylase O06993 Eno Enolase P37869 Pgi Glucose-6-phosphate isomerase P80860 EpsH Putative glycosyltransferase P71057 Antioxidant katA...”
- Characterization of a novel D-lyxose isomerase from Cohnella laevoribosii RI-39 sp. nov
Cho, Journal of bacteriology 2007 - “...P0A858 tpiA, E. coli triose phosphate isomerase; P27876 tpiA, B. subtilis triose phosphate isomerase; AAC75844 fucI, E. coli fucose isomerase; AAL21854...”
- On the origin of mitochondria: a genomics perspective
Andersson, Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2003 - “...U23081, P29613, P17751, M83294, AE000685, U28760, P27876, NCF000911, O08408, Q9Z520, AAL74288, AP002995/Q98ME7, Q8YHF5, Q92QA1, AB039932, U77930, AE005863,...”
P35144 triose-phosphate isomerase (EC 5.3.1.1) from Priestia megaterium (see paper)
63% identity, 100% coverage
TPIS_BACCE / Q4MQ55 Triosephosphate isomerase; TIM; TPI; Triose-phosphate isomerase; EC 5.3.1.1 from Bacillus cereus (see paper)
WR52_26170 triose-phosphate isomerase from Bacillus cereus
63% identity, 100% coverage
- function: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P).
catalytic activity: D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate (RHEA:18585)
subunit: Homodimer. - The interaction between flagellin and the glycosphingolipid Gb3 on host cells contributes to Bacillus cereus acute infection
Gao, Virulence 2020 - “...using FlowJo software. Preparation of recombinant proteins The gene fragments of flagellin (WR52_08290), triosephosphate isomerase (WR52_26170), and superoxide dismutase (WR52_27745) were amplified by PCR from the genome of B. cereus HN001 (GenBank No. CP011155.1). The primers used to amplify these fragments are listed in Table S2....”
BAS4987 triosephosphate isomerase from Bacillus anthracis str. Sterne
63% identity, 100% coverage
- Changes in Bacillus anthracis CodY regulation under host-specific environmental factor deprived conditions
Kim, BMC genomics 2016 - “...from different clusters; from UP cluster I, we chose the triosephosphate isomerase ( tpiA ; BAS4987 ) and tellurium resistance ( yceC ; BAS0385 ) gene. From DN cluster 4, we chose the methionyl-tRNA synthetase gene ( BAS4903 ). From cluster 6, we chose a putative...”
- “...7.13 3.25 BCD -Fe 0.97 5.57 BCD -Bic 0.36 0.26 BCD -Glu 0.08 0.37 tpiA (BAS4987) 34F2 R 1 1 Cluster 1 34F2 -Fe ND 0.52 34F2 -Bic 0.02 4.49 34F2 -Glu 0.36 0.04 BCD R 9.85 1.95 BCD -Fe 1.5 1.62 BCD -Bic ND 0.07...”
IGB08_04525 triose-phosphate isomerase from Lactiplantibacillus plantarum
Q88YH4 Triosephosphate isomerase from Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
lp_0791 triosephosphate isomerase from Lactobacillus plantarum WCFS1
64% identity, 98% coverage
lmo2457 highly similar to triose phosphate isomerase from Listeria monocytogenes EGD-e
63% identity, 100% coverage
E6J203 Triosephosphate isomerase from Streptococcus anginosus F0211
60% identity, 100% coverage
- Intracellular proteins moonlighting as bacterial adhesion factors
Jeffery, AIMS microbiology 2018 - “...yeast invertase [54] Superoxide dismutase Mycobacterium avium P53647 adhesin [98] Triose phosphate isomerase Streptococcus oralis E6J203 plasminogen [78] 6. Conclusions The large number of ISMPs, the variety of bacterial species, and the different host proteins targeted suggests that this phenomenon of intracellular housekeeping proteins moonlighting as...”
- Physical Features of Intracellular Proteins that Moonlight on the Cell Surface
Amblee, PloS one 2015 - “...D9RMW0 [ 99 ] Triose phosphate isomerase plasminogen binding Streptococcus anginosus and S . oralis E6J203 [ 50 ] Thiol-specific antioxidant protein (TSA1) plasminogen binding Candida albicans C4YNZ5 [ 26 ] The proteins in this study [ 20 99 ] were selected with the criteria that...”
SSU0483 triosephosphate isomerase from Streptococcus suis P1/7
SSU05_0531 triosephosphate isomerase from Streptococcus suis 05ZYH33
60% identity, 98% coverage
- Precision Genome Engineering in Streptococcus suis Based on a Broad-Host-Range Vector and CRISPR-Cas9 Technology
Gussak, ACS synthetic biology 2023 - “...citZ 2.92 SSU1042 acnA 2.93 glycolysis SSU0153 Plr 1.17 SSU0154 Pgk 1.28 SSU0312 Fba 1.56 SSU0483 Tpi 1.12 SSU0927 Ldh 1.34 SSU1308 bglH 1.41 SSU1309 1.54 SSU1320 Eno 1.46 SSU1451 gpmA 1.47 SSU1836 Pgi 1.07 pyrimidine metabolism SSU0735 pyrR 2.55 SSU0736 pyrB 2.45 SSU0737 carA 2.54...”
- Characterization of the pivotal carbon metabolism of Streptococcus suis serotype 2 under ex vivo and chemically defined in vitro conditions by isotopologue profiling
Willenborg, The Journal of biological chemistry 2015 - “...molecules are interconvertible by a triosephosphate isomerase (tpiA, SSU0483), and therefore, one half of the molecules in the GAP pool consists of [2,313...”
- The roles of RelA/(p)ppGpp in glucose-starvation induced adaptive response in the zoonotic Streptococcus suis
Zhang, Scientific reports 2016 - “...between SC-19 and relA in glycolysis showed obvious difference. In glycolytic pathway, fbaABCD (SSU05_0336-0339), tpiA (SSU05_0531), gapA (SSU05_0155), gpmAB (SSU05_1638, SSU05_0520) and eno (SSU05_1503) encoding five reversible enzymes, which could convert fructose-1,6-bis-P to phosphoenol-pyruvate, were more than two-fold down-regulated in SC-19 during glucose starvation. Because gluconeogenesis...”
tpiA / O32757 triosephosphate isomerase subunit (EC 5.3.1.1) from Lactobacillus delbrueckii subsp. bulgaricus (see paper)
58% identity, 98% coverage
BFP66_RS02590 triose-phosphate isomerase from Streptococcus suis
60% identity, 98% coverage
- A novel aquaporin Aagp contributes to Streptococcus suis H2O2 efflux and virulence
Zhu, Virulence 2023 - “...fructose-bisphosphate aldolase; glycolysis BFP66_RS07495 2.61 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; BFP66_RS06470 2.19 pyruvate kinase; BFP66_RS06865 2.36 enolase; BFP66_RS02590 2.86 triose-phosphate isomerase; BFP66_RS00790 2.16 type I glyceraldehyde-3-phosphatedehydrogenase; BFP66_RS00845 2.35 sugar ABC transporter substrate-binding protein; sugar ABC transporters BFP66_RS00850 2.22 sugar ABC transporter permease; BFP66_RS02995 8.65 sugar ABC transporter permease;...”
HSISS4_00409 triose-phosphate isomerase from Streptococcus salivarius
59% identity, 100% coverage
LBA0700 triosephosphate isomerase from Lactobacillus acidophilus NCFM
58% identity, 98% coverage
- Lactobacillus acidophilus-Rutin Interplay Investigated by Proteomics
Mazzeo, PloS one 2015 - “...a CARBOHYDRATE METABOLISM glyceraldehyde-3-p dehydrogenase LBA0698 Glycolysis / Gluconeogenesis UP b (2.5) triosephosphate isomerase tpiA LBA0700 Glycolysis / Gluconeogenesis / Fructose and mannose metabolism DOWN(-1.8) pyruvate kinase kpyK LBA0957 Glycolysis / Gluconeogenesis / Pyruvate metabolism UP(1.8) D-lactate dehydrogenase ldhD LBA0055 Pyruvate metabolism DOWN(-1.7) isomerase LBA0651 Pentose...”
SSA_0859 Triosephosphate isomerase, putative from Streptococcus sanguinis SK36
58% identity, 99% coverage
- Involvement of signal peptidase I in Streptococcus sanguinis biofilm formation
Aynapudi, Microbiology (Reading, England) 2017 - “...SSA_1062 5.75 11.69 50S ribosomal protein L27 No SSA_0688 5.77 32.78 2,3-bisphosphoglycerate-dep phosphoglycerate mutase No SSA_0859 7.75 62.77 Triosephosphate isomerase No SSA_0813 9.7 11.04 Thioredoxin reductase No SSA_0772 9.91 75.4 PTS family porter, phosphocarrier protein HPR No SSA_0878 11.11 16.27 DNA gyrase subunit B No SSA_1896...”
EF1962 triosephosphate isomerase from Enterococcus faecalis V583
58% identity, 100% coverage
- A TIR domain protein from E. faecalis attenuates MyD88-mediated signaling and NF-κB activation
Zou, PloS one 2014 - “...We performed a PCR amplification using oligonucleotide primers that anneal to flanking ORFs EF1956 and EF1962 using genomic DNA as template. Agarose gel electrophoresis of PCR amplicons showed an expected product of 4.7 Kb in E99 (reference band), smaller amplicons of 4 Kb in D6 and...”
- “...EF1959 locus encoding TcpF. (A) Genome diversity in the region of EF1959 (ORFs EF1956 to EF1962) is indicated by varying size of the PCR amplicons obtained from DNA of E. faecalis E99 (reference band) and three other unrelated strains D6, OG1RF, T3. M: 1 Kb size...”
- Growth rate-dependent control in Enterococcus faecalis: effects on the transcriptome and proteome, and strong regulation of lactate dehydrogenase
Mehmeti, Applied and environmental microbiology 2012 - “...EF1353 EF1354 EF1356 EF1416 EF1526 EF1612 EF1962 EF1963 EF1964 EF0283 Phosphotransferase system, mannose-specific IIAB components Phosphoglycerate mutase 1...”
- Use of recombinase-based in vivo expression technology to characterize Enterococcus faecalis gene expression during infection identifies in vivo-expressed antisense RNAs and implicates the protease Eep in pathogenesis
Frank, Infection and immunity 2012 - “...EF0722 EF0798 EF1348 EF1591 EF1755 EF1809 EF1826 EF1918 EF1962 EF1978 EF2207 EF2380 EF2570 EF2668 EF2744 EF2889 EF3008 EF3056 EF3124 EF3177 EF3258 OG1RF0176...”
- Transcriptome, proteome, and metabolite analyses of a lactate dehydrogenase-negative mutant of Enterococcus faecalis V583
Mehmeti, Applied and environmental microbiology 2011 - “...glyceraldehyde-3-phosphate dehydrogenase (EF1964) protein and triosephosphate isomerase (EF1962) protein than the wild type did. The transcriptomic data for the...”
- “...Central intermediary metabolism Cell envelope Energy metabolism EF1900 EF1962 EF1964 EF2151 EF2193 EF2425 etaR araD fba luxS asd panB tpiA gap-2 glmS epaF...”
PWH42_01065 triose-phosphate isomerase from Pediococcus acidilactici
60% identity, 98% coverage
- Draft Genome Sequence of a Putative Raw Milk-Associated Probiotic Bacterium, Pediococcus acidilactici ISO17
Makete, Microbiology resource announcements 2023 - “...PWH42_07080 MDD9323765.1 Pyruvate oxidase Adhesion PWH42_00630 MDD9322523.1 Glucose-6-phosphate isomerase PWH42_01055 MDD9322606.1 Type I glyceraldehyde-3-phosphate dehydrogenase PWH42_01065 MDD9322608.1 Triose-phosphate isomerase PWH42_01070 MDD9322609.1 Phosphopyruvate hydratase or enolase PWH42_01510 MDD9322680.1 Elongation factor Tu PWH42_05240 MDD9323412.1 Tyrosine-protein phosphatase PWH42_06015 MDD9323565.1 Class A sortase PWH42_08100 MDD9323964.1 LPXTG cell wall anchor domain-containing...”
TPIS_GEOSE / P00943 Triosephosphate isomerase; TIM; TPI; Triose-phosphate isomerase; EC 5.3.1.1 from Geobacillus stearothermophilus (Bacillus stearothermophilus) (see 3 papers)
P00943 triose-phosphate isomerase (EC 5.3.1.1) from Geobacillus stearothermophilus (see paper)
57% identity, 100% coverage
- function: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P).
catalytic activity: D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate (RHEA:18585)
subunit: Homodimer. - b2bTools: online predictions for protein biophysical features and their conservation.
Kagami, Nucleic acids research 2021 - “...predictions, with the sidechain, coil, and ppII values turned off, for the Bs protein (Uniprot P00943, a structure is available as PDB code 1BTM; note that such structure information is not used in our predictions). This protein has low DisoMine (disorder) values, except for the last...”
- A taxonomy of bacterial microcompartment loci constructed by a novel scoring method.
Axen, PLoS computational biology 2014 - “...0000079-F20 locus additionally encodes a protein 44% identical to triosephosphate isomerase (TIM) (EC: 5.3.1.1; UniProtKB: P00943), which catalyzes the reversible conversion of glyceraldehyde-3-phosphate to dihydroxyacetone phosphate. When acted on by an aldolase, sugar phosphates can be metabolized to either or both of these products, in some...”
SMU_RS03370 triose-phosphate isomerase from Streptococcus mutans UA159
P72484 Triosephosphate isomerase from Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
57% identity, 100% coverage
- Mass spectrometry and split luciferase complementation assays reveal the MecA protein interactome of Streptococcus mutans
Qin, Microbiology spectrum 2024 - “...5 Iron-containing alcohol dehydrogenase family protein SMU_RS01955 3.8 Formate C-acetyltransferase, PflB SMU_RS05480 3.4 6-phosphofructokinase, PfkA SMU_RS03370 3.1 Triose-phosphate isomerase, TpiA SMU_RS07095 3 Glycogen/starch/alpha-glucan phosphorylase, GlgP SMU_RS00740 2.1 2.6 4 Bifunctional acetaldehyde-CoA/alcohol dehydrogenase, AdhE SMU_RS03175 2.3 3 Aconitate hydratase, AcnA SMU_RS05475 2.2 Pyruvate kinase, Pyk SMU_RS01780 2.2...”
- Identification of the antibacterial action mechanism of diterpenoids through transcriptome profiling
Moon, Frontiers in microbiology 2022 - “...SMU_RS05480 6-Phosphofructokinase pfkA 0.78 1.77 1.82 1.80 SMU_RS00520 Fructose-bisphosphate aldolase fbaA 0.53 1.81 1.83 1.89 SMU_RS03370 Triose-phosphate isomerase tpiA 0.48 1.48 1.39 1.37 SMU_RS01775 Type I glyceraldehyde-3-phosphate dehydrogenase gapC 1.87 1.71 1.82 SMU_RS01445 Transketolase tkt 1.68 3.84 3.28 3.36 SMU_RS05685 Phosphopentomutase deoB 0.83 2.30 2.24 2.23...”
- S-glutathionylation proteome profiling reveals a crucial role of a thioredoxin-like protein in interspecies competition and cariogenecity of Streptococcus mutans
Li, PLoS pathogens 2020 - “...carboxylase subunit Q8DTF8 pckA 236, 324 Phosphoenolpyruvate carboxykinase Q59939 Carbon metabolism citZ 13 Citrate synthase P72484 tpiA 127, 128, 188 Triosephosphate isomerase Q8DVV3 gapC 153, 157 Glyceraldehyde-3-phosphate dehydrogenase Q8DUP4 Alanine, aspartate and glutamate metabolism carA (pyrA) 76 Carbamoyl-phosphate synthase small chain Q8DTY0 glmS 2, 493 Glutaminefructose-6-phosphate...”
SGO_0762 triosephosphate isomerase from Streptococcus gordonii str. Challis substr. CH1
A8AWA1 Triosephosphate isomerase from Streptococcus gordonii (strain Challis / ATCC 35105 / BCRC 15272 / CH1 / DL1 / V288)
58% identity, 100% coverage
1btmA / P00943 Triosephosphate isomerase (tim) complexed with 2-phosphoglycolic acid (see paper)
57% identity, 100% coverage
- Ligand: 2-phosphoglycolic acid (1btmA)
tpiA / P50918 triosephosphate isomerase subunit (EC 5.3.1.1) from Lactococcus lactis subsp. lactis (strain IL1403) (see paper)
60% identity, 98% coverage
T303_03545 triose-phosphate isomerase from Streptococcus thermophilus ASCC 1275
58% identity, 100% coverage
- Proteomic analysis reveals potential factors associated with enhanced EPS production in Streptococcus thermophilus ASCC 1275
Padmanabhan, Scientific reports 2020 - “...phosphate pathway (phosphopentomutase T303_06455; ribose 5-phosphate isomerase, T303_06460; transketolase, T303_02705), glycolysis (6-phosphofructokinase, T303_03155; triosephosphate isomerase, T303_03545), pyruvate metabolism (phosphoenol pyruvate carboxylase, T303_04815; pyruvate dehydrogenase E2 component, T303_06185; pyruvate dehydrogenase E1 component, T303_06190; pyruvate dehydrogenase E2 component alpha subunit, T303_06195; phosphoacetyl transferase, T303_08140; formate acetyltransferase, T303_09120; lactoyl...”
- Transcriptomic Insights Into the Growth Phase- and Sugar-Associated Changes in the Exopolysaccharide Production of a High EPS-Producing Streptococcus thermophilus ASCC 1275
Padmanabhan, Frontiers in microbiology 2018 - “...T303_02705, T303_06460), pyruvate metabolism (T303_00220, T303_06880, T303_08140, T303_08165) and some genes of glycolysis pathway (T303_02195, T303_03545, T303_04345, T303_06845, T303_09745). S10h showed the upregulation of more genes in carbohydrate metabolic pathway especially those responsible for glycolysis, pyruvate metabolism and pentose phosphate pathway. Genes involved in galactose metabolism...”
SK141_RS01855 triose-phosphate isomerase from Streptococcus oralis
58% identity, 100% coverage
SP_1574 triosephosphate isomerase from Streptococcus pneumoniae TIGR4
P66942 Triosephosphate isomerase from Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
SPD_1404 triosephosphate isomerase from Streptococcus pneumoniae D39
58% identity, 100% coverage
LACR_1244 Triosephosphate isomerase from Lactococcus lactis subsp. cremoris SK11
59% identity, 98% coverage
tpi / AAC43268.1 triosephosphate isomerase from Lactococcus lactis subsp. lactis (see paper)
LLNZ_07340 triose-phosphate isomerase from Lactococcus cremoris subsp. cremoris NZ9000
llmg_1424 TpiA protein from Lactococcus lactis subsp. cremoris MG1363
59% identity, 98% coverage
LGG_00935 triosephosphate isomerase (TIM) (Triose-phosphate isomerase) (Lactacin B inducer protein) (IP) from Lactobacillus rhamnosus GG
LGG_00935 triose-phosphate isomerase from Lacticaseibacillus rhamnosus GG
57% identity, 98% coverage
T285_RS06185 triose-phosphate isomerase from Lactobacillus johnsonii N6.2
56% identity, 98% coverage
- Identification of Biomarkers for Systemic Distribution of Nanovesicles From Lactobacillus johnsonii N6.2
Harrison, Frontiers in immunology 2021 - “...IsoleucinetRNA ligase 17.34 5.89 0.75 0.0004 0.020 T285_RS05935 Glucose-6-phosphate isomerase 25.94 12.35 1.12 0.53 0.037 T285_RS06185 Triosephosphate isomerase 18.36 8.51 3.36 0.53 0.046 T285_RS06195 Glyceraldehyde-3-phosphate dehydrogenase 98.35 15.73 15.67 2.69 0.005 T285_RS06765 ThreoninetRNA ligase 38.42 6.29 4.48 0.003 0.006 T285_RS07040 Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B 27.22 9.02...”
SPy0613 putative triosephosphate isomerase from Streptococcus pyogenes M1 GAS
58% identity, 98% coverage
CRIB_189 triose-phosphate isomerase from Romboutsia ilealis
56% identity, 98% coverage
- Genomic and functional analysis of Romboutsia ilealis CRIBT reveals adaptation to the small intestine
Gerritsen, PeerJ 2017 - “...1,6-bisphosphatase (CRIB_45 and CRIB_2020); 10, 6-phosphofructokinase ; (CRIB_104); 11, fructose-bisphosphate aldolase (CRIB_2223); 12, triosephosphate isomerase (CRIB_189); 13, glyceraldehyde-3-phosphate dehydrogenase (CRIB_187); 14, phosphoglycerate kinase; 15, phosphoglycerate mutase (CRIB_1223) and 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (CRIB_190); 16, enolase (CRIB_191); 17, pyruvate kinase (CRIB_105); 18, L-lactate dehydrogenase (CRIB_684); 19, formate acetyltransferase...”
CAETHG_1758 triose-phosphate isomerase from Clostridium autoethanogenum DSM 10061
53% identity, 98% coverage
- Comparison of single-molecule sequencing and hybrid approaches for finishing the genome of Clostridium autoethanogenum and analysis of CRISPR systems in industrial relevant Clostridia
Brown, Biotechnology for biofuels 2014 - “...(Pfk6) CAETHG_648, 2439, G 4 Fructose bisphosphate aldolase (Aldo) CAETHG_2382, G 5 Triose-phosphate isomerase (Tpi) CAETHG_1758, G 6 Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) CAETHG_1760, 3424, G 7 Phosphoglycerate kinase (Pgk) CAETHG_1759, G 8 Phosphoglycerate mutase (Pgm) CAETHG_712, 1757, G 9 Enolase phosphopyruvate hydratase (Eno) CAETHG_1756. During autotrophic growth,...”
TPIS_CLOPE / Q8XKU1 Triosephosphate isomerase; TIM; TPI; Triose-phosphate isomerase; EC 5.3.1.1 from Clostridium perfringens (strain 13 / Type A) (see paper)
54% identity, 98% coverage
- function: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P).
catalytic activity: D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate (RHEA:18585)
subunit: Homodimer.
CD3172 triosephosphate isomerase from Clostridium difficile 630
55% identity, 98% coverage
- A microbiota-generated bile salt induces biofilm formation in Clostridium difficile
Dubois, NPJ biofilms and microbiomes 2019 - “...polIII ( CD1305 ), rpoA ( CD0098 ), pgi ( CD3285 ), and tpi ( CD3172 ). c ELISA-based quantification of TcdA production by cells grown in the absence or presence of 240M DOC or 240M CHO. Concentrations were standardized to the amount of protein as...”
- Inactivation of the dnaK gene in Clostridium difficile 630 Δerm yields a temperature-sensitive phenotype and increases biofilm-forming ability
Jain, Scientific reports 2017 - “...gene expression was reported relative to the expression of the triose phosphate isomerase gene tpi (CD3172) in C. difficile 630 erm . Table 3 PCR primers. Gene Locus Description PPrimer Sequence (53) Binding position Product size (bp) Annealing temperature (C) Reference tpi CD3172 triosephosphate isomerase tpi-Ftpi-R...”
- Comparative transcriptional analysis of clinically relevant heat stress response in Clostridium difficile strain 630
Ternan, PloS one 2012 - “...and the reverse primers of the individual genes targeted. The triose phosphate isomerase gene, tpi (CD3172), and 16S rRNA were used as reference genes [22] and 2.5 l cDNA was used as template in 10 l q-PCR reactions (LightCycler 2.0 Carousel-Based System) using the LightCycler FastStart...”
- Global transcriptional control by glucose and carbon regulator CcpA in Clostridium difficile
Antunes, Nucleic acids research 2012 - “...upregulated by CcpA. glgCDA (CD0882CD0884), glycogen biosynthesis; fbp (CD1191), fructose-1,6-bisphosphatase; fba (CD0403), fructose-1,6-bisphosphate aldolase; tpi (CD3172), triosephosphate isomerase; gapA (CD3174) and gapB (CD1767), glyceraldehyde-3-phosphate dehydrogenase; pgk (CD3173), phosphoglycerate kinase; gpmI (CD3171), 2,3-bisphosphoglycerate-mutase; eno (CD3170), enolase; pykF (CD3394), pyruvate kinase; fumB (CD1004), fumarate hydratase subunit B; CD1005,...”
Ccel_2260 phosphoglycerate kinase from Clostridium cellulolyticum H10
Ccel_2260 triose-phosphate isomerase from Ruminiclostridium cellulolyticum H10
57% identity, 38% coverage
- Whole Proteome Analyses on Ruminiclostridium cellulolyticum Show a Modulation of the Cellulolysis Machinery in Response to Cellulosic Materials with Subtle Differences in Chemical and Structural Properties
Badalato, PloS one 2017 - “...6-phosphofructokinase (Ccel_2612, pfkA), the xylose isomerase (Ccel_3429, xylA), the glyceraldehyde-3-phosphate dehydrogenase (Ccel_2275), the phosphoglycerate kinase (Ccel_2260), the phosphoglycerate mutase (Ccel_0619), the 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (Ccel_2259, gpmI) and the phosphopyruvate hydratase, also known as enolase (Ccel_2254, eno). All 8 of them are enzymes from upstream of the...”
CA_C0711 triose-phosphate isomerase from Clostridium acetobutylicum ATCC 824
CAC0711 Triosephosphate isomerase from Clostridium acetobutylicum ATCC 824
54% identity, 98% coverage
- Clostridium acetobutylicum grows vegetatively in a biofilm rich in heteropolysaccharides and cytoplasmic proteins
Liu, Biotechnology for biofuels 2018 - “...8 3.3 Acetoacetate decarboxylase 27 CA_P0162 3768 95,774 175 32 3.2 Alcohol dehydrogenase E 28 CA_C0711 452 26,698 17 11 3.1 Triosephosphate isomerase 29 CA_C2597 461 17,599 19 5 3.1 Hypothetical protein 30 CA_C3558 1128 48,599 51 10 3.0 Probable S-layer protein a All scores were...”
- Fermentation of oxidized hexose derivatives by Clostridium acetobutylicum
Servinsky, Microbial cell factories 2014 - “...2) phosphoglucose isomerase, CA_C2680; 3) phosphofructokinase, CA_C0517; 4) fructose-bis-P aldolase, CA_C0827, CA_P0064; 5) triosephosphate isomerase, CA_C0711; 6) glyceradehyde-3-P dehydrogenase, CA_C0709; 7) phosphoglycerate kinase, CA_C0710; 8) phosphoglycerate mutase, CA_C0712, CA_C2741, CA_C3021; 9) enolase, CA_C0713; 10) pyruvate kinase, CA_C0518, CA_C1036; 11) pyruvate ferredoxin oxidoreductase, CA_C2229, CA_C2499; 12) hydrogenase,...”
- The role of PerR in O2-affected gene expression of Clostridium acetobutylicum
Hillmann, Journal of bacteriology 2009 - “...Energy conversion CAP0162 CAP0163 CAP0164 CAC0116 CAC0587 CAC0711 CAC0712 CAC0713 CAC2452 CAC2458 CAC2459 CAC2499 CAC2708 CAC2709 CAC2710 CAC2711 CAC2712...”
- “...to CAC3292, CAC3624 and CAC3625, CAP0162 to CAP0164, CAC0711 to CAC0713, CAC2458 and CAC2459, CAC2708 to CAC2712, CAC3075 and CAC3076, CAC3657 to CAC3659,...”
- Transcriptional program of early sporulation and stationary-phase events in Clostridium acetobutylicum
Alsaker, Journal of bacteriology 2005 - “...time points, including the triosephosphate isomerase gene (tpi, CAC0711; 2.0-fold higher, time point G), gap (CAC0709; 2.2-fold higher, time point H), the...”
- Overexpression of groESL in Clostridium acetobutylicum results in increased solvent production and tolerance, prolonged metabolism, and changes in the cell's transcriptional program
Tomas, Applied and environmental microbiology 2003 - “...expression in 824(pGROE1), including triosephosphate isomerase (CAC0711), enolase (CAC0713), and pfk (CAC0232). 824(pGROE1) growth displays increased tolerance...”
F502_06077 triose-phosphate isomerase from Clostridium pasteurianum DSM 525 = ATCC 6013
53% identity, 98% coverage
TKV_c16320 triose-phosphate isomerase from Thermoanaerobacter kivui
52% identity, 98% coverage
Clocel_0721 triose-phosphate isomerase from Clostridium cellulovorans 743B
55% identity, 98% coverage
- Clostridium cellulovorans Proteomic Responses to Butanol Stress
Costa, Frontiers in microbiology 2021 - “...grown in butanol-supplemented conditions. However, three glycolytic enzymes, namely phosphoglycerate kinase (Clocel_0720), triose phosphate isomerase (Clocel_0721) and pyruvate phosphate dikinase (Clocel_1454) were down-regulated in butanol-challenged C. cellulovorans . Interestingly, up-regulation of some/most key glycolytic enzymes was reported in other bacteria (e.g., C. acetobutylicum , S. warneri...”
pgk / P36204 Pgk (EC 2.7.2.3; EC 5.3.1.1) from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see 4 papers)
PGKT_THEMA / P36204 Bifunctional PGK/TIM; EC 2.7.2.3; EC 5.3.1.1 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see 3 papers)
P36204 triose-phosphate isomerase (EC 5.3.1.1) from Thermotoga maritima (see 2 papers)
TM0689 phosphoglycerate kinase/triose-phosphate isomerase from Thermotoga maritima MSB8
51% identity, 38% coverage
Cthe_0139 triosephosphate isomerase from Clostridium thermocellum ATCC 27405
Clo1313_2093 triose-phosphate isomerase from Acetivibrio thermocellus ATCC 27405
53% identity, 96% coverage
Q03SL6 Triosephosphate isomerase from Levilactobacillus brevis (strain ATCC 367 / BCRC 12310 / CIP 105137 / JCM 1170 / LMG 11437 / NCIMB 947 / NCTC 947)
47% identity, 98% coverage
CA51_20800 triose-phosphate isomerase from Rosistilla oblonga
49% identity, 100% coverage
Poly24_21710 triose-phosphate isomerase from Rosistilla carotiformis
49% identity, 100% coverage
Mal33_21820 triose-phosphate isomerase from Rosistilla oblonga
49% identity, 100% coverage
A4XKV2 Multifunctional fusion protein from Caldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903 / Tp8T 6331)
Csac_1952 Phosphoglycerate kinase., Triose-phosphate isomerase from Caldicellulosiruptor saccharolyticus DSM 8903
50% identity, 38% coverage
TepiRe1_2127 triose-phosphate isomerase from Tepidanaerobacter acetatoxydans Re1
48% identity, 98% coverage
GSU1628 phosphoglycerate kinase/triosephosphate isomerase from Geobacter sulfurreducens PCA
49% identity, 38% coverage
- Proteomic Analysis of a Syntrophic Coculture of Syntrophobacter fumaroxidans MPOBT and Geobacter sulfurreducens PCAT
Mollaei, Frontiers in microbiology 2021 - “...(Fbp), glucose-6-phosphate isomerase (Pgi), acetolactate synthase (IlvB), ketol-acid reductoisomerase (IlvC), 2-isopropylmalate synthase (CimA), triose-phosphate isomerase (GSU1628), transketolase, C-terminal subunit (GSU2918), transketolase, N-terminal subunit (GSU2919), transaldolase (Tal), aspartate transaminase (GSU1061), threonine synthase (ThrC), (TdcB), 3-isopropylmalate dehydrogenase (LeuB), (GlyA), NADH oxidase, putative or FAD-dependent pyridine nucleotide-disulfide oxidoreductase family...”
- Comparative proteomics of Geobacter sulfurreducens PCAT in response to acetate, formate and/or hydrogen as electron donor
Mollaei, Environmental microbiology 2021 - “...(Fbp), glucose6phosphate isomerase (Pgi), acetolactate synthase (IlvB), ketolacid reductoisomerase (IlvC), 2isopropylmalate synthase (CimA), triosephosphate isomerase (GSU1628), transketolase, Cterminal subunit (GSU2918), transketolase, Nterminal subunit (GSU2919), transaldolase (Tal), aspartate transaminase (GSU1061), threonine synthase (ThrC), (TdcB), 3isopropylmalate dehydrogenase (LeuB), (GlyA), NADH oxidase, putative or FADdependent pyridine nucleotidedisulfide oxidoreductase family...”
PFCIRM129_11290 triose-phosphate isomerase from Propionibacterium freudenreichii subsp. freudenreichii
49% identity, 95% coverage
- Extracellular Vesicles Produced by the Probiotic Propionibacterium freudenreichii CIRM-BIA 129 Mitigate Inflammation by Modulating the NF-κB Pathway
Rodovalho, Frontiers in microbiology 2020 - “...PFCIRM129_06070), aconitase (Acn, PFCIRM129_04640), glutamine synthetase (GlnA1, PFCIRM129_11730), glucose-6-phosphate isomerase (Gpi, PFCIRM129_10645), triosephosphate isomerase (Tpi1, PFCIRM129_11290), the surface-layer proteins SlpB (PFCIRM129_00700) and SlpE (PFCIRM129_05460), the BopA solute binding protein (PFCIRM129_08120), internaline A (InlA, PFCIRM129_12235), the hypothetical protein PFCIRM129_10785 and the GroL2 chaperonin (PFCIRM129_10100) ( Le Marchal...”
- “...Others, such as glutamine synthetase (GlnA1, PFCIRM129_11730), glucose-6-phosphate isomerase (Gpi, PFCIRM129_10645) and triosephosphate isomerase (Tpi1, PFCIRM129_11290), have also been described as moonlighting proteins, with adhesin functions, in other species ( Kainulainen et al., 2012 ; Rodrguez-Bolaos and Perez-Montfort, 2019 ). As well as metabolism-related proteins, other...”
SYNPCC7002_A0595 triosephosphate isomerase from Synechococcus sp. PCC 7002
46% identity, 98% coverage
Amuc_0562 Triose-phosphate isomerase from Akkermansia muciniphila ATCC BAA-835
AMUC_RS03080 triose-phosphate isomerase from Akkermansia muciniphila ATCC BAA-835
47% identity, 99% coverage
- Strategies for high cell density cultivation of Akkermansia muciniphila and its potential metabolism
Wu, Microbiology spectrum 2024 - “...GAPDH, while dihydroxyacetone phosphate can be reversibly converted to glyceraldehyde 3-phosphate by triose phosphate isomerase (Amuc_0562) or converted to glycerol 3-phosphate by GPDH. Figure 6C presents that the transcriptional expression level of GAPDH and GPDH genes in the optimized medium was much higher than that in...”
- Analysis of Akkermansia muciniphila in Mulberry Galacto-Oligosaccharide Medium via Comparative Transcriptomics
Li, Foods (Basel, Switzerland) 2023 - “...) AGTAAGCGTGGTTGGTGAGG AAACGCCCTGTCTATCCGTC AMUC_RS07935 ( pfk ) TTATGCCGTGGAACTGGTGG TTCCTCAATGGGTACGGCAG AMUC_RS03915 ( fbaA ) TAGGCAATTCCGCCCTTGG TGTGAAGGGCTACGAGAACG AMUC_RS03080 ( tpiA ) TGGAACCCGTGCTGGAAATC TAGGCGATGACCAGGTTGGA AMUC_RS07575 ( gapA ) TTGCTCCGATGGTGAAGGTG GCTGGTCGTTCGTGTAGGAG AMUC_RS07580 ( pgk ) TGAAATGGACTGCTTCGCCA CGCCGCCTACAATGGAAATG AMUC_RS01755 ( gpml ) TGTGGAGCAGTGTTATGCGA TTATCCCTCACGCGCTGTTC AMUC_RS04575 ( eno ) CTGGAAGCCACGGAACAAAC AAACACCCAGAATGGCGTTG AMUC_RS02385...”
- “...1.85 1.68 up AMUC_RS03915 ( fbaA ) class II fructose-bisphosphate aldolase 1.87 2.21 2.85 up AMUC_RS03080 ( tpiA ) triose-phosphate isomerase 1.98 2.12 1.87 up AMUC_RS07575 ( gapA ) type I glyceraldehyde-3-phosphate dehydrogenase 2.12 2.54 2.74 up AMUC_RS07580 ( pgk ) phosphoglycerate kinase 2.01 1.84 2.32...”
TPIS_STRCO / Q9Z520 Triosephosphate isomerase; TIM; TPI; Triose-phosphate isomerase; EC 5.3.1.1 from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) (see paper)
SCO1945 triosephosphate isomerase from Streptomyces coelicolor A3(2)
48% identity, 97% coverage
- function: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P).
catalytic activity: D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate (RHEA:18585)
subunit: Homodimer. - Comparative proteomic analysis of Streptomyces lividans Wild-Type and ppk mutant strains reveals the importance of storage lipids for antibiotic biosynthesis
Le, Applied and environmental microbiology 2013 - “...40 Up Up 4 3 SCO7443 SCO3649 SCO1945 Q9L117 Q9X8R6 Q9Z520 57/5.3 37/5.4 28/5.2 165 107 162 36 35 34 Down Down Down 4 3 3 Dihydrolipoamide dehydrogenase Probable...”
- On the origin of mitochondria: a genomics perspective
Andersson, Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2003 - “...M83294, AE000685, U28760, P27876, NCF000911, O08408, Q9Z520, AAL74288, AP002995/Q98ME7, Q8YHF5, Q92QA1, AB039932, U77930, AE005863, Q8XXP9, Q9HV51, AE001305....”
- A Proteomic Analysis Indicates That Oxidative Stress Is the Common Feature Triggering Antibiotic Production in Streptomyces coelicolor and in the pptA Mutant of Streptomyces lividans
Lejeune, Frontiers in microbiology 2021 - “...of the phosphofructokinases SCO1214 (group I) and SCO5426 (group II), and the triose phosphate isomerase SCO1945 (TPI, step 5). Glc6P being the entry point of the pentose phosphate pathway (PPP), the low abundance of the GPI/SCO6659 as well as that of the PFK/SCO1957 and TPI/SCO1945, in...”
- Differential transcription of expanded gene families in central carbon metabolism of Streptomyces coelicolor A3(2)
Schniete, Access microbiology 2020 - “...coelicolor was grown on tween as would be expected, with GO enrichment analysis highlighting tpiA (SCO1945), pyk1 (SCO2014) and pyk2 (SCO5423), one of the three GAPDH (SCO7511) and a single copy of the pyruvate dehydrogenase E1 complex (SCO2183), it was noted that all genes belonged in...”
- Expression of genes of the Pho regulon is altered in Streptomyces coelicolor
Millan-Oropeza, Scientific reports 2020 - “...4A ). On glucose, these trioses whose inter-conversion is catalyzed by the triose phosphate isomerase SCO1945 (TPI, step 5) can then be converted into glycerol 3P (Glycerol3P) by glycerol 3P dehydrogenases whereas on glycerol, Gly3P results from the phosphorylation of glycerol by an ATP dependent glycerol...”
- “...kinase (PYK, SCO2014) 42 . Interestingly, the Fructose bis-phosphate aldolase (SCO3649, step 4), the TPI SCO1945, the pyruvate phosphate dikinase SCO2494 and the fructose 1, 6 bisphosphatase SCO5047 were more abundant on glycerol than on glucose in both strains at 48h and 72h. The abundance of...”
- Comparative proteomic analysis of Streptomyces lividans Wild-Type and ppk mutant strains reveals the importance of storage lipids for antibiotic biosynthesis
Le, Applied and environmental microbiology 2013 - “...glyceraldehyde-3-phosphate (GA3P), and a triose phosphate isomerase (SCO1945, step 5) that catalyzes the interconversion between DHAP and GA3P. In contrast, the...”
- “...36/5.2 135 140 28 40 Up Up 4 3 SCO7443 SCO3649 SCO1945 Q9L117 Q9X8R6 Q9Z520 57/5.3 37/5.4 28/5.2 165 107 162 36 35 34 Down Down Down 4 3 3 Dihydrolipoamide...”
- ArgR of Streptomyces coelicolor is a versatile regulator
Pérez-Redondo, PloS one 2012 - “...SCO1814 inhA enoyl-(acyl carrier protein) reductase 0.007 Down 6445 SCO1935 tktA1 transketolase 0.033 Down 6497 SCO1945 tpiA triosephosphate isomerase 0.015 Down 6233 SCO1946 pgk phosphoglycerate kinase 0.008 Down 6193 SCO1947 gap1 glyceraldehyde-3-phosphate dehydrogenase 0.029 Down 6666 SCO1965 export associated protein 0.015 Down 6494 SCO1998 rpsA 30S...”
- “...pentose phosphate pathway, which finally results in formation of D-glyceraldehyde-3-phosphate; the triose phosphate isomerase TpiA (SCO1945, spot IN 6497), which interconverts glyceraldehyde-3-phosphate and hydroxyacetone; the phosphoglycerate kinase Pgk (SCO1946, spot IN 6233) and a glyceraldehyde-3-phosphate dehydrogenase isoenzyme Gap1 (SCO1947, spot IN 6193). Also, the deoxyribose-phosphate aldolase...”
- Rapid functional screening of Streptomyces coelicolor regulators by use of a pH indicator and application to the MarR-like regulator AbsC
Yang, Applied and environmental microbiology 2010 - “...O O 11 2 Glycolysis and TCA SCO1945 SCO1947 SCO2180 SCO2181 SCO4808 SCO4827 SCO7511 Triosephosphate isomerase, TpiA Glyceraldehyde-3-phosphate dehydrogenase,...”
A5VHW7 Triosephosphate isomerase from Limosilactobacillus reuteri (strain DSM 20016)
46% identity, 99% coverage
C789_4415 triose-phosphate isomerase from Microcystis aeruginosa FACHB-905 = DIANCHI905
48% identity, 98% coverage
DEFDS_0129 triose-phosphate isomerase from Deferribacter desulfuricans SSM1
45% identity, 99% coverage
CA54_32530 triose-phosphate isomerase from Symmachiella macrocystis
45% identity, 98% coverage
alr4385 triosephosphate isomerase from Nostoc sp. PCC 7120
45% identity, 98% coverage
- The Anabaena sp. PCC 7120 Exoproteome: Taking a Peek outside the Box
Oliveira, Life (Basel, Switzerland) 2015 - “...4 + Photosynthesis and respiration - Alr4238 Alr4238 protein NH 4 + Other categories Anabaena Alr4385 Triosephosphate isomerase NH 4 + Energy metabolism - Alr4448 Endo-1,4-beta-xylanase N 2 Other categories - Alr4550 Uncharacterized protein alr4550 N 2 , NO 3 , NH 4 + Conserved hypothetical...”
Pan258_47170 triose-phosphate isomerase from Symmachiella dynata
45% identity, 98% coverage
UWK_00786 triose-phosphate isomerase from Desulfocapsa sulfexigens DSM 10523
43% identity, 98% coverage
- Complete genome sequence of Desulfocapsa sulfexigens, a marine deltaproteobacterium specialized in disproportionating inorganic sulfur compounds
Finster, Standards in genomic sciences 2013 - “...Glucose-6-phosphate isomerase (UWK_01632), fructose 6-phosphate kinase (UWK_01908), fructose-1,6-bisphosphatase (UWK_03194), fructose bisphosphate aldolase (UWK_02512), triosephosphate isomerase (UWK_00786; UWK _01623), glyceraldehyde-3 phosphate dehydrogenase (UWK_01687), phosphoenol pyruvate synthase (UWK_00627; UWK__02176; UWK _02650), 3-phosphoglycerate kinase (UWK_00787), 2,3 phosphoglycerate mutase (UWK_03186) and pyruvate kinase (UWK_00304; UWK _00318; UWK _00709) are encoded...”
Mal52_48110 triose-phosphate isomerase from Symmachiella dynata
45% identity, 98% coverage
BB341_RS22335 triose-phosphate isomerase from Streptomyces clavuligerus
45% identity, 97% coverage
Ava_3290 Triosephosphate isomerase from Anabaena variabilis ATCC 29413
45% identity, 98% coverage
6neeB Crystal structure of a reconstructed ancestor of triosephosphate isomerase from eukaryotes (see paper)
48% identity, 98% coverage
- Ligand: phosphoglycolohydroxamic acid (6neeB)
R1CNI7 Triosephosphate isomerase from Emiliania huxleyi
44% identity, 100% coverage
- The cellular response to ocean warming in Emiliania huxleyi
Dedman, Frontiers in microbiology 2023 - “...interconversion between glyceraldehyde-3-phosphate and dihydroxyacetone phosphate ( Zaffagnini et al., 2014 ). This protein (R1BGG4; R1CNI7) was significantly raised in the elevated warming treatment relative to both the control and moderate warming treatments ( q 0.01). Related to this, abundance of glyceraldehyde-3-phosphate dehydrogenase (R1DPS6) was recorded...”
6bveA / Q59994 Triosephosphate isomerase of synechocystis in complex with 2- phosphoglycolic acid (see paper)
slr0783 triosephosphate isomerase from Synechocystis sp. PCC 6803
45% identity, 98% coverage
- Ligand: 2-phosphoglycolic acid (6bveA)
- Site-2 Protease Slr1821 Regulates Carbon/Nitrogen Homeostasis during Ammonium Stress Acclimation in Cyanobacterium Synechocystis sp. PCC 6803
Lin, International journal of molecular sciences 2023 - “...subunit ( slr0009 and slr0012 ), phospho-glycerate kinase ( slr0394 ), triose phosphate isomerase ( slr0783 ), sedoheptulose bisphosphatase ( slr2094 ), transketolase ( sll1070 ), phosphopentose epimerase ( sll0807 ) and phosphoribulose kinase ( sll1525 ). While WT only notably repressed 11% of photosynthesis genes,...”
- Diurnal Regulation of Cellular Processes in the Cyanobacterium Synechocystis sp. Strain PCC 6803: Insights from Transcriptomic, Fluxomic, and Physiological Analyses
Saha, mBio 2016 - “...pgk / slr0394 ), sedoheptulose-1,7-bisphosphatase ( glpX / slr2094 ), triosephosphate isomerase ( tpiA / slr0783 ), phosphoglycerate mutase ( gpm / slr1945 ), and two isoforms of pyruvate dehydrogenase ( pdh / sll1721 and slr1934 ) that were upregulated at the beginning of the light...”
- A transcriptional regulator Sll0794 regulates tolerance to biofuel ethanol in photosynthetic Synechocystis sp. PCC 6803
Song, Molecular & cellular proteomics : MCP 2014 - “...Sll1980 Slr0064 Slr0080 Slr0115 Slr0288 Slr0646 Slr0649 Slr0783 Slr0809 Slr0889 Slr0984 Slr1490 Slr1718 Slr1829 Ssl2296 Ssr2061 Mutant_r1 vs. Control_r1 Ratio...”
- Highly expressed and alien genes of the Synechocystis genome
Mrázek, Nucleic acids research 2001 - “...glycolysis and photosynthetic CO2 fixation, triosephosphate isomerase (tpi, slr0783), is not PHX [E(g) = 0.77]. Between the two copies of gap genes, gap2 [E(g)...”
- “...isomerase (rpiA) sll1070 1.31 669 Transketolase (tktA) slr0783 [0.77] 241 Triosephosphate isomerase (tpi) sll0199 1.32 125 ssl0020 1.14 96 Electron transport...”
- Pathway alignment: application to the comparative analysis of glycolytic enzymes
Dandekar, The Biochemical journal 1999 - “...coT co co co co co co pfk coT coT co co slr0783 328 tpi 0537 1438 0055 3919 0678 0194 431 0213 0360 1304 1528 1041 1884 YDR050C slr0884 sll1342 505 gapa gapb...”
DET0742 triosephosphate isomerase from Dehalococcoides ethenogenes 195
45% identity, 100% coverage
- New insights into Dehalococcoides mccartyi metabolism from a reconstructed metabolic network-based systems-level analysis of D. mccartyi transcriptomes
Islam, PloS one 2014 - “...106 2 113 hypothetical protein putative bifunctional phosphoglucose/phosphomannose isomerase Retain previous annotation Central Carbon Metabolism DET0742 160 2 192 triosephosphate isomerase Retain previous annotation Retain previous annotation Central Carbon Metabolism DET0369 84 2 57 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase Retain previous annotation Retain previous annotation Lipid Metabolism DET0371...”
- “...6B ). In the metabolic modeling study [23] , the central metabolic genes (DET0509 and DET0742) of this cluster were suggested to be involved in glycolysis/gluconeogenesis and sugar metabolism to produce precursors for cell membrane biogenesis [57] [59] . DET0509 (hypothetical protein) was annotated as a...”
Pro0901 Triosephosphate isomerase from Prochlorococcus marinus str. SS120
45% identity, 98% coverage
- Glucose uptake and its effect on gene expression in prochlorococcus
Gómez-Baena, PloS one 2008 - “...rpi 5.3.1.6 Pro1644 Transketolase tktA 2.2.1.1 Pro1770 Transaldolase tal 2.2.1.2 Pro0519 Triosephosphate isomerase tpi 5.3.1.1 Pro0901 Glyceraldehyde-3-phosphate dehydrogenase gap3 1.2.1.12 Pro1577 3-phosphoglycerate kinase pgk 2.7.2.3 Pro0221 Phosphoglycerate mutase gpmB 5.4.2.1 Pro0515 Enolase eno 4.2.1.11 Pro0235 Piruvate kinase pykF 2.7.1.40 Pro0923 Fructose-1,6-bisphosphatase aldolase I fda 4.1.2.13 Pro0856...”
8w06B Crystal structure of the reconstruction of the ancestral triosephosphate isomerase of the last opisthokont common ancestor obtained by maximum likelihood with pgh (see paper)
47% identity, 98% coverage
- Ligand: phosphoglycolohydroxamic acid (8w06B)
YP_003432274 triosephosphate isomerase from Hydrogenobacter thermophilus TK-6
47% identity, 97% coverage
- Phylogenetic position of aquificales based on the whole genome sequences of six aquificales species
Oshima, International journal of evolutionary biology 2012 - “...YP_003432507 ribosomal protein L22 YP_003432144 Holliday junction resolvase YP_003432824 DNA processing protein YP_003432257 GTP-binding protein YP_003432274 triosephosphate isomerase YP_003432330 aspartate 1-decarboxylase YP_003432353 uridylate kinase YP_003432374 ribosomal protein L24 YP_003432380 ribosomal protein S5 YP_003432524 transcription antitermination protein YP_003432640 methionyl-tRNA formyltransferase YP_003433333 ribosomal protein L20 YP_003432384 adenylate kinase...”
Q7NAQ4 triose-phosphate isomerase (EC 5.3.1.1) from Mycoplasma gallisepticum (see paper)
45% identity, 97% coverage
Alvin_2432 triosephosphate isomerase from Allochromatium vinosum DSM 180
44% identity, 99% coverage
lpp2838 triosephosphate isomerase from Legionella pneumophila str. Paris
43% identity, 99% coverage
- The Legionella pneumophila genome evolved to accommodate multiple regulatory mechanisms controlled by the CsrA-system
Sahr, PLoS genetics 2017 - “...to catabolize glucose to pyruvate. Additionally, the transcript of the glycolysis protein triosephosphate isomerase ( lpp2838 ) is down-regulated in csrA - strain. Furthermore, the ribose-5-phosphate isomerase A ( lpp0108) of the pentose phosphate pathway, the pyruvate dehydrogenase complex ( lpp1461 ) and the 2-oxoglutarate dehydrogenase...”
- “...2.60 lpp0108 Ribose-5-phosphate isomerase A 18.08 / 0.62 lpp1516 Pyruvate/2-oxoglutarate dehydrogenase complex 18.92 0.62 / lpp2838 Tpi, Triosephosphate isomerase 9.46 0.48 / lpp2931 RNA pyrophosphohydrolase 69.62 / 0.53 lpp0597 SucA, 2 -oxoglutarate dehydrogenase E1 subunit 38.36 / 0.65 lpp0986 Alanine dehydrogenase 49.88 0.63 / lpp0535 Fba,...”
lpg2792 triosephosphate isomerase (TIM) from Legionella pneumophila subsp. pneumophila str. Philadelphia 1
42% identity, 99% coverage
4y96A / A0A0M3KL18 Crystal structure of triosephosphate isomerase from gemmata obscuriglobus (see paper)
44% identity, 99% coverage
- Ligand: phosphate ion (4y96A)
BB0055 triosephosphate isomerase from Borrelia burgdorferi B31
46% identity, 98% coverage
- Borrelia host adaptation Regulator (BadR) regulates rpoS to modulate host adaptation and virulence factors in Borrelia burgdorferi
Miller, Molecular microbiology 2013 - “...the putative BosR-regulated genes displayed significant expression changes in badR including: bb0020 ( pfpB ), bb0055 ( tpi ), and bbb29 (malX ), a PtsG homolog ( Table 1 , and accession GSE38827). Collectively, these results suggest BadR functions as a versatile ROK regulator, regulating both...”
- “...pBVSR2713 BB0831 cloned into pET23a This study pMP4 BB0545 cloned into pET23a This study pCLM26 BB0055 cloned into pET23a This study pBVSR3212 BB0694 cloned into pET23a This study pCLM12 upstream (732988734094) and downstream (735259736264) flanking Str r cassette in pCR2.1 for BB0693 deletion 733108735289 upstream and...”
- BosR (BB0647) controls the RpoN-RpoS regulatory pathway and virulence expression in Borrelia burgdorferi by a novel DNA-binding mechanism
Ouyang, PLoS pathogens 2011 - “...ttatTAAATTAAATtgtt BB0020 pfpB Pyrophosphatefructose 6-phosphate 1-phosphotransferase, beta subunit atcaTAAATTAAATatta BB0036 parE DNA topoisomerase IV tttaTAAATTAAATttta BB0055 tpiA triosephosphate isomerase cagaTAAATTAAATttat BB0086 conserved hypothetical protein gtttTAAATTAAATttcc BB0097 hypothetical protein cactTAAATTAAATctca BB0141 mtrC membrane fusion protein tttcTAAATTAAATgata BB0141 aagaTAAATTAAATtatg BB0259 hypothetical protein atttTAAATTAAATtcaa BB0300 ftsA cell division protein...”
- Whole-genome DNA array analysis of the response of Borrelia burgdorferi to a bactericidal monoclonal antibody
Anderton, Infection and immunity 2004 - “...in response to CB2 at 25 min. BB0055 and BB0056, triosephosphate isomerase and phosphoglycerate kinase, respectively, are located immediately upstream of...”
- “...Putative identification Log ratio valuea Fold induction Location BB0055 BB0056 BB0354 BB0603 BBA39 BBA40 BBA41 BBA57 BBD12 BBD18 BBL25 BBL26 BBM25 BBP23 BBP25...”
Mal48_48530 triose-phosphate isomerase from Thalassoglobus polymorphus
44% identity, 98% coverage
Mal4_33520 triose-phosphate isomerase from Maioricimonas rarisocia
43% identity, 98% coverage
MAP1166 Tpi from Mycobacterium avium subsp. paratuberculosis str. k10
46% identity, 95% coverage
TPIS_MYCTU / P9WG43 Triosephosphate isomerase; TIM; TPI; Triose-phosphate isomerase; EC 5.3.1.1 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 3 papers)
P9WG43 triose-phosphate isomerase (EC 5.3.1.1) from Mycobacterium tuberculosis (see 2 papers)
NP_215954 triosephosphate isomerase from Mycobacterium tuberculosis H37Rv
Rv1438 triosephosphate isomerase from Mycobacterium tuberculosis H37Rv
45% identity, 95% coverage
- function: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P).
catalytic activity: D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate (RHEA:18585)
subunit: Homodimer. - Structural and functional characterization of Mycobacterium tuberculosis triosephosphate isomerase.
Connor, Acta crystallographica. Section D, Biological crystallography 2011 (PubMed)- GeneRIF: revealed significant conformational change in active-site loops 6 and 7 of triosephosphate isomerase when bound to a reaction-intermediate analog
- Application of Distributive Conjugal DNA Transfer in Mycobacterium smegmatis To Establish a Genome-Wide Synthetic Genetic Array
Judd, Journal of bacteriology 2017 - “...synthase --b -- Rv0563 Rv3421c Rv3193c Rv2754c Rv2710 Rv1438 Rv0455c -- Rv2221c Rv0823c Lethal Lethal Sick/lethal Lethal Lethal Sick Lethal Lethal Sick Lethal...”
- Genetic-and-Epigenetic Interspecies Networks for Cross-Talk Mechanisms in Human Macrophages and Dendritic Cells during MTB Infection
Li, Frontiers in cellular and infection microbiology 2016 - “...Ms and DCs. In Figure 4 , there are three pathogen proteins (Rv0667, Rv0762c, and Rv1438) interacting with host proteins (UBC, EGFR). In addition, there are other pathogen proteins (Rv2404c, Rv1696, and Rv1098c) that may help Rv0667, Rv0762c, and Rv1438 promote host-pathogen interactions. This suggests that...”
- “...Ms, inducing the influence on M invasion. In addition, Rv2404c, Rv0667, Rv0762c, Rv1098c, Rv1696, and Rv1438 are localized on the cell wall. This is consistent with the pathogenesis of Mtb in which membrane proteins influence the host immune response and enhance pathogen survival ability. The host...”
- Integration of Metabolic Modeling with Gene Co-expression Reveals Transcriptionally Programmed Reactions Explaining Robustness in Mycobacterium tuberculosis
Puniya, Scientific reports 2016 - “...which are positively correlated with both Rv1336 and Rv2334 include Rv1436 (GAPD), Rv1437 (PGK) , Rv1438 (TPI), Rv0489 (PGM), Rv0952 (SUCOAS), Rv0694 (LDH_L) and Rv1304-Rv1311 (ATPS4r). The expression of these genes were negatively correlated with Rv0848 . Conversely, expression of genes coding for fumarate reductase (...”
- Systematic Analysis of Mycobacterial Acylation Reveals First Example of Acylation-mediated Regulation of Enzyme Activity of a Bacterial Phosphatase
Singhal, The Journal of biological chemistry 2015 - “...code 1YWF) (50), Rv1240 (PDB code 4TVO) (51), and Rv1438 (PDB code 3TA6) (52) were retrieved from the PDB database. For other proteins, homology modeling was...”
- “...Rv0410c Rv0467 Rv0491 Rv0685 Rv0694 Rv1240 Rv1436 Rv1437 Rv1438 Rv1617 Rv1694 Rv1872c Rv2611c Rv2703 Rv2875 Rv2889c Rv3248c Rv3366 Rv3846 Rv3875 Protein name...”
- Deciphering the metabolic response of Mycobacterium tuberculosis to nitrogen stress
Williams, Molecular microbiology 2015 - “...0.01 1 1 Phthiocerol precursor ligase Rv2930 Down d1 <0.001 9 5 Rv1408, Rv1436, Rv1437, Rv1438, Rv1449, Rv1611, Rv1612, Rv1613 d2 0.037 2 1 Phosphatidylglycerol synthase Rv1822, Rv2289, Rv2746 d3 0.037 2 1 Pyridoxine 5 phosphate oxidase Rv2607 d4 0.037 2 1 Pyridoxal oxidase Rv2607 d5...”
- Triosephosphate isomerase is dispensable in vitro yet essential for Mycobacterium tuberculosis to establish infection
Trujillo, mBio 2014 - “...enzymes ( 19 , 20 ). The M.tuberculosis genome contains a single tpi gene ( rv1438 ), predicted to be required for optimal growth on agar plates ( 21 24 ). TPI from M.tuberculosis has been biochemically and structurally characterized ( 25 , 26 ). It...”
- Key role for the alternative sigma factor, SigH, in the intracellular life of Mycobacterium avium subsp. paratuberculosis during macrophage stress
Ghosh, Infection and immunity 2013 - “...MAP1166 MAP4025 MAP3201 MAP3202 MAP3204 MAP3203 Rv0467 Rv2465c Rv1438 Rv0529 Rv3145 Rv3146 Rv3148 Rv3147 97.36 96.17 91.57 76.92 73.43 91.3 95.21 86.01 Cell...”
- Sequence-based analysis uncovers an abundance of non-coding RNA in the total transcriptome of Mycobacterium tuberculosis
Arnvig, PLoS pathogens 2011 - “...1.3 Rv2520c CMP II.C.5 463 73 29 0.4 Rv3136 PPE51 IV.C.1 457 92 28 0.3 Rv1438 tpi I.B.1 458 29 26 0.9 Rv1156 CHP V 610 75 23 0.3 Rv3527 HP VI 372 5 23 4.6 *3 UTR extends into the adjacent CDS as an antisense...”
- More
3taoA / P9WG43 Structure of mycobacterium tuberculosis triosephosphate isomerase bound to phosphoglycolohydroxamate (see paper)
45% identity, 96% coverage
- Ligand: phosphoglycolohydroxamic acid (3taoA)
A6WC54 Triosephosphate isomerase from Kineococcus radiotolerans (strain ATCC BAA-149 / DSM 14245 / SRS30216)
44% identity, 95% coverage
CT328 Triosephosphate Isomerase from Chlamydia trachomatis D/UW-3/CX
43% identity, 90% coverage
LT988_02660 triose-phosphate isomerase from Thiocapsa bogorovii
42% identity, 98% coverage
SO1200 triosephosphate isomerase from Shewanella oneidensis MR-1
40% identity, 95% coverage
A6WRH2 Triosephosphate isomerase from Shewanella baltica (strain OS185)
40% identity, 95% coverage
BJD94_12630 triose-phosphate isomerase from Vibrio vulnificus Env1
43% identity, 94% coverage
- Loss of the Acetate Switch in Vibrio vulnificus Enhances Predation Defense against Tetrahymena pyriformis
Rasheedkhan, Applied and environmental microbiology 2022 - “...isomerase, gpi Glucose-6-phosphate to fructose-6-phosphate BJD94_12175 1.8042 2.374E07 6-Phosphofructokinase, pfkA Fructose 6-phosphate to fructose 1,6-bisphosphate BJD94_12630 1.379 1.121E07 Triosephosphate isomerase, tpiA Dihydroxyacetone phosphate (DHAP) to d -glyceraldehyde-3-phosphate (G3P) BJD94_12290 1.3784 6.156E10 22C3-bisphosphoglycerate-independent phosphoglycerate mutase, gpmI 2-Phosphoglycerate (2-PGA) and 3-phosphoglycerate (3-PGA) BJD94_13755 1.345 0.0002797 Enolase, eno 2-PGA...”
A2FT29 triose-phosphate isomerase (EC 5.3.1.1) from Trichomonas vaginalis (see 2 papers)
43% identity, 95% coverage
MSMEG_3086 triosephosphate isomerase from Mycobacterium smegmatis str. MC2 155
45% identity, 95% coverage
- Monitoring global protein thiol-oxidation and protein S-mycothiolation in Mycobacterium smegmatis under hypochlorite stress
Hillion, Scientific reports 2017 - “...398 (+484)TPGNPR(E) 4,94 MSMEG_6759 GlpK3 Glycerol kinase (K)NGLLTTVC 294 (+484)YR(L) 10,73 (R)ATLESIC 389 (+484)YQSR(D) 5,67 MSMEG_3086 TpiA Triosephosphate isomerase (R)VAGAADAQEVC 192 (+484)K(A) 2,04 MSMEG_0911 AceA Isocitrate lyase (K)NGLEPC 268 (+484)IAR(A) 11,36 MSMEG_5676 CitA Citrate synthase (R)TIDEC 143 (+484)PTVTAR(F) 14,23 MSMEG_5049 Kgd 2-oxoglutarate metabolism enzyme (R)SSEYC 695...”
- Identifying feasible metabolic routes in Mycobacterium smegmatis and possible alterations under diverse nutrient conditions
Baloni, BMC microbiology 2014 - “...isomerase, 6-phosphofructokinase, fructose-bisphosphate aldolase, phosphoglycerate mutase, pyruvate kinase are encoded by more than 1 gene. MSMEG_3086, MSMEG_6785 code for triose phosphate isomerase enzyme. A multiple sequence alignment shown in Figure 3 d indeed indicates that they are similar to each other [ 29 ]. It is...”
- Identification of protein partners in mycobacteria using a single-step affinity purification method
Płociński, PloS one 2014 - “...an RNA polymerase sigma factor SigJ, specifically co-purified with MSMEG_4121, a GntR transcriptional regulator. Finally, MSMEG_3086, predicted to be triosephosphate isomerase (TpiA) when used as a bait, co-purified with MSMEG_3085, a phosphoglycerate kinase (Pgk) from the same operon but not vice versa. Pgk, on the other...”
TPIS_MORMI / P50921 Triosephosphate isomerase; TIM; TPI; Triose-phosphate isomerase; EC 5.3.1.1 from Moritella marina (Vibrio marinus) (see paper)
P50921 triose-phosphate isomerase (EC 5.3.1.1) from Moritella marina (see 2 papers)
tpiA / PDB|1AW1_A triose-phosphate isomerase; EC 5.3.1.1 from Moritella marina (see paper)
44% identity, 94% coverage
- function: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P).
catalytic activity: D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate (RHEA:18585)
subunit: Homodimer.
NCgl1524 triose-phosphate isomerase from Corynebacterium glutamicum ATCC 13032
cg1789 triosephosphate isomerase from Corynebacterium glutamicum ATCC 13032
46% identity, 92% coverage
- Transcriptome and Multivariable Data Analysis of Corynebacterium glutamicum under Different Dissolved Oxygen Conditions in Bioreactors
Sun, PloS one 2016 - “...dehydrogenase E2 component (dihydrolipoamide acetyltransferase) (NCgl0090), and pyruvate dehydrogenase E1 component (NCgl2167), whereas triosephosphate isomerase (NCgl1524) was up-regulated, indicating that the metabolism from the glycolytic pathway toward the TCA cycle was weakened under 0% DO. Previous studies showed that when the ETC is restricted the glycolysis...”
- “...to consume intracellular ATP [ 44 ]. Our transcriptome data showed that the triosephosphate isomerase (NCgl1524) gene in glycolytic pathway was up-regulated. The TCA shunt restricted NADH production, which was reflected by the up-regulation of the glyoxylate pathway at low DO due to the up-regulation of...”
- Altered acetylation and succinylation profiles in Corynebacterium glutamicum in response to conditions inducing glutamate overproduction
Mizuno, MicrobiologyOpen 2016 - “...Pfk, 6phosphofructokinase (NCgl1202); GlpX, fructose 1,6bisphosphatase II (NCgl0976); Fba, fructosebisphosphate aldolase (NCgl2673); TpiA, triosephosphate isomerase (NCgl1524); Gap, glyceraldehyde3phosphate dehydrogenase (NCgl1526); GapX, glyceraldehyde3phosphate dehydrogenase (NCgl0900); Pgk, phosphoglycerate kinase (NCgl1525); GpmA, phosphoglyceromutase (NCgl0390); Eno, enolase (NCgl0935); Pyk, pyruvate kinase (NCgl2008); Zwf, glucose6phosphate 1dehydrogenase (NCgl1514); DevB, 6phosphogluconolactonase (NCgl1516); Gnd,...”
- CRISPRi-Library-Guided Target Identification for Engineering Carotenoid Production by Corynebacterium glutamicum
Göttl, Microorganisms 2021 - “...plasmid carrying the tkt (cg1774) sgRNA This work pS_dCas9_ tpi pS_dCas9 plasmid carrying the tpi (cg1789) sgRNA This work pS_dCas9_ zwf pS_dCas9 plasmid carrying the zwf (cg1778) sgRNA This work...”
VAS14_21527 triose-phosphate isomerase from Photobacterium angustum S14
VAS14_21527 triosephosphate isomerase from Vibrio angustum S14
41% identity, 96% coverage
- Proteome analysis of the UVB-resistant marine bacterium Photobacterium angustum S14
Matallana-Surget, PloS one 2012 - “...VAS14_08340 inorganic pyrophosphatase 0.84 1.30 6 0.80 1.22 6 0.78 1.14 7 0.86 1.26 8 VAS14_21527 triosephosphate isomerase 0.84 1.13 4 0.71 1.09 7 0.84 1.15 7 0.71 1.32 6 VAS14_10584 3-deoxy-7-phosphoheptulonate synthase 0.95 1.09 10 0.82 1.26 11 0.80 1.28 14 0.80 1.29 12 VAS14_05653...”
- “...VAS14_06013 glyceraldehyde-3-phosphate dehydrogenase 2 35441 146 0.2 VAS14_22994 glutamine synthetase 3 51536 121 0.2 18D VAS14_21527 triosephosphate isomerase 0.71 2.55E-10 8 26968 374 0.59 1D VAS14_14099 16 kDa heat shock protein A 0.75 2.95E-06 4 16561 325 1.11 10D VAS14_20756 putative 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase 0.75 1.38E-08 15...”
A2EGX9 triose-phosphate isomerase (EC 5.3.1.1) from Trichomonas vaginalis (see 3 papers)
XP_001320336 Chain A Triosephosphate isomerase from Trichomonas vaginalis G3
43% identity, 95% coverage
Q8MPF2 triose-phosphate isomerase (EC 5.3.1.1) from Tenebrio molitor (see 2 papers)
44% identity, 98% coverage
Tpi / b3919 triose-phosphate isomerase (EC 5.3.1.1) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
tpiA / P0A858 triose-phosphate isomerase (EC 5.3.1.1) from Escherichia coli (strain K12) (see 32 papers)
TPIS_ECODH / B1XB85 Triosephosphate isomerase; TIM; TPI; Triose-phosphate isomerase; EC 5.3.1.1 from Escherichia coli (strain K12 / DH10B) (see paper)
TPIS_ECOLI / P0A858 Triosephosphate isomerase; TIM; TPI; Triose-phosphate isomerase; EC 5.3.1.1 from Escherichia coli (strain K12) (see 8 papers)
P0A858 triose-phosphate isomerase (EC 5.3.1.1) from Escherichia coli (see paper)
4mvaA 1.43 angstrom resolution crystal structure of triosephosphate isomerase (tpia) from escherichia coli in complex with acetyl phosphate. (see paper)
tpiA / RF|NP_418354 triose-phosphate isomerase from Escherichia coli K12 (see 4 papers)
NP_418354 triose-phosphate isomerase from Escherichia coli str. K-12 substr. MG1655
P0A860 Triosephosphate isomerase from Escherichia coli O157:H7
UTI89_C4503 triosephosphate isomerase from Escherichia coli UTI89
b3919 triosephosphate isomerase from Escherichia coli str. K-12 substr. MG1655
c4871 Triosephosphate isomerase from Escherichia coli CFT073
SF5M90T_3496 triose-phosphate isomerase from Shigella flexneri 5a str. M90T
43% identity, 99% coverage
- function: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P).
catalytic activity: D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate (RHEA:18585)
subunit: Homodimer. - function: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P).
catalytic activity: D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate (RHEA:18585)
subunit: Homodimer.
disruption phenotype: Cells lacking this gene accumulates methylglyoxal and are unable to grow on glucose, lactate or other carbon sources. - Ligand: acetylphosphate (4mvaA)
- Functional Prediction of Biological Profile During Eutrophication in Marine Environment
Sbaoui, Bioinformatics and biology insights 2022 - “...Cytochrome c-type protein in TMAO respiration; with TorA, also negative regulator of tor operon TpiA P0A858 Triosephosphate isomerase Tsr P02942 Protein methyl-accepting chemotaxis proteinserine-sensing UgpA P10905 Sn-glycerol-3-phosphate transport system permease protein UmuD P0AG11 Component of DNA polymerase V, signal peptidase with UmuC Ung P12295 Uracil-DNA-glycosylase UraA...”
- The Protein Interactome of Glycolysis in Escherichia coli
Chowdhury, Proteomes 2021 - “...9 0 3 FbaB P0A991 Fructose-bisphosphate aldolase class 1 Fructose-1,6-bisphosphate (FBP) 4 0 4 TpiA P0A858 Triosephosphate isomerase Glyceraldehyde-3-phosphate (GAP) 22 0 5 GapA P0A9B2 Glyceraldehyde-3-phosphate dehydrogenase A Glyceraldehyde-3-phosphate (GAP) 52 4 6 Pgk P0A799 Phosphoglycerate kinase 1,3-bisphosphoglycerate (1,3-BPG) 38 1 7 GpmA P62707 2,3-bisphosphoglycerate-dependent phosphoglycerate...”
- Mass spectrometry-based workflow for accurate quantification of Escherichia coli enzymes: how proteomics can play a key role in metabolic engineering
Trauchessec, Molecular & cellular proteomics : MCP 2014 - “...P0A6T1 P0AC41 P0A9P0 P61889 P0A836 P0A955 P62707 P0A858 P08200 P0A6A3 P23538 P06958 P08997 Pathway Molecular weight (Da) Glycolysis Gluconeogenesis Glyoxylate...”
- A curated C. difficile strain 630 metabolic network: prediction of essential targets and inhibitors.
Larocque, BMC systems biology 2014 - “...ispF P0AD61 [51%] P14618-2 [44%] FPP (Q8EBR3 [62%]); GPP (P62617 [55%]); IPP (A0R559 [34%]) murD P0A858 [44%] P60174-1 [44%] LK1, LK2, LK3, LK4, LKM (P14900 [32%]); ntpA - P38606 [51%] ADH , 911 , Tiludronate , BafilomycinA1, Bafilomycin B1 (P38606, [51%]); QUE, APP, AUR, PIT, TLX...”
- Characterization of a novel D-lyxose isomerase from Cohnella laevoribosii RI-39 sp. nov
Cho, Journal of bacteriology 2007 - “...ri, Acinetobacter sp. strain DL-28 L-ribose isomerase; P0A858 tpiA, E. coli triose phosphate isomerase; P27876 tpiA, B. subtilis triose phosphate isomerase;...”
- The Escherichia coli proteome: past, present, and future prospects
Han, Microbiology and molecular biology reviews : MMBR 2006 - “...P02930 Outer membrane protein 5.23/51,468.93 TpiA P0A858 Triosephosphate isomerase 5.64/26,971.81 Tpx P0A862 Thiol peroxidase 4.75/17,704.12 TreA P13482...”
- RNase G controls tpiA mRNA abundance in response to oxygen availability in Escherichia coli.
Lee, Journal of microbiology (Seoul, Korea) 2019 (PubMed)- GeneRIF: RNase G cleaves the 5' untranslated region of triosephosphate isomerase A (tpiA) mRNA, leading to destabilization of the mRNA in E. coli.
- Two-dimensional gel electrophoresis of Escherichia coli homogenates: the Escherichia coli SWISS-2DPAGE database.
Pasquali, Electrophoresis 1996 (PubMed)- GeneRIF: N-terminus verified by Edman degradation on complete protein
- Yeast Mannan-Rich Fraction Modulates Endogenous Reactive Oxygen Species Generation and Antibiotic Sensitivity in Resistant E. coli
Smith, International journal of molecular sciences 2022 - “...1 1 3 5 0.03 0.92 0.88 0.18 4.14 0.04 MRF + AMP EMP Pathway P0A860 TPIA 2 2 15 5 3.20 0.01 0.12 0.61 3.08 0.08 MRF P62709 GPMA 7 7 39 31 0.93 0.04 0.16 0.50 0.4 0.19 MRF Q8XDE9 GPMI 9 9 78...”
- Cathelicidin Peptides Restrict Bacterial Growth via Membrane Perturbation and Induction of Reactive Oxygen Species
Rowe-Magnus, mBio 2019 - “...Heat shock protein HslJ hslJ UTI89_C2016 1.16 1.97E06 Mannose-specific enzyme IIC component of PTS manY UTI89_C4503 1.16 1.76E03 Triosephosphate isomerase tpiA UTI89_C1002 1.19 2.19E03 Asparaginyl-tRNA synthetase asnS UTI89_C2472 1.19 4.17E03 Cytochrome c -type biogenesis protein CcmH ccmH UTI89_C3842 1.22 1.78E03 Elongation factor G fusA UTI89_C4647 1.25...”
- Automated characterization and analysis of expression compatibility between regulatory sequences and metabolic genes in Escherichia coli
Wen, Synthetic and systems biotechnology 2024 - “...b2935 tktA Transketolase b2943 galP Galactose/H+ symporter b3041 ribB 3,4-Dihydroxy-2-butanone-4-phosphate synthase b3916 pfkA 6-Phosphofructokinase 1 b3919 tpiA Triose-phosphate isomerase b4025 pgi Glucose-6-phosphate isomerase b3956 ppc Phosphoenolpyruvate carboxylase b4090 rpiB Ribose-5-phosphate isomerase b3386 rpe Ribulose 5-phosphate 3-epimerase b3403 pck Phosphoenolpyruvate carboxykinase b3612 gpmM Phosphoglycerate mutase b3952 pflC...”
- Expression of Phosphofructokinase Is Not Sufficient to Enable Embden-Meyerhof-Parnas Glycolysis in Zymomonas mobilis ZM4
Felczak, Frontiers in microbiology 2019 - “...assembly was used, with Hind III digested pRL pfkA as the backbone and PCR-amplified tpiA (b3919) and fbaA (b2925) as inserts. tpiA and fbaA were amplified from MG1655 genomic DNA using primers listed in Table 1 . These primers introduced a FLAG-tag (GACTACAAAGACGATGACGACAAG) at the end...”
- Systems Biology Approach to Bioremediation of Nitroaromatics: Constraint-Based Analysis of 2,4,6-Trinitrotoluene Biotransformation by Escherichia coli
Iman, Molecules (Basel, Switzerland) 2017 - “...reversible transport (periplasm) nh4[p] <=> nh4[c] (b0451 or s0001) TPI Triose-phosphate isomerase dhap[c] <=> g3p[c] b3919 GLYCDx Glycerol dehydrogenase glyc[c] + nad[c] -> dha[c] + h[c] + nadh[c] b3945 NO2t2rpp Nitrite transport in via proton symport, reversible (periplasm) h[p] + no2[p] <=> h[c] + no2[c] (b3367...”
- Refactoring the Embden-Meyerhof-Parnas Pathway as a Whole of Portable GlucoBricks for Implantation of Glycolytic Modules in Gram-Negative Bacteria
Sánchez-Pascuala, ACS synthetic biology 2017 - “...pgi ( b4025 ), pfkA ( b3916 ), fbaA ( b2925 ), and tpiA ( b3919 ); and the second one, termed GlucoBrick Module II , comprising gapA ( b1779 ), pgk ( b2926 ), gpmA ( b0755 ), eno ( b2779 ), and pykF (...”
- Quantitative assessment of thermodynamic constraints on the solution space of genome-scale metabolic models
Hamilton, Biophysical journal 2013 - “...b4226 ppa Lethal Lethal Nonlethal Lethal Nonlethal Lethal b3919 tpiA Nonlethal Nonlethal Lethal Lethal Lethal Lethal Worse in TMFA b1849 purT Nonlethal...”
- “...falsely predicted a lethal phenotype ( b1949 , b2500 , and b3919 ) when FBA predicted a nonlethal one ( Table 1 ). In these cases, we hypothesized that the SL...”
- A computational exploration of bacterial metabolic diversity identifying metabolic interactions and growth-efficient strain communities
Tzamali, BMC systems biology 2011 - “...Biosynthesis' 'Cofactor and Prosthetic Group Biosynthesis' 'Glycine and Serine Metabolism' 'Threonine and Lysine Metabolism' 0.97 b3919 'triose phosphate isomerase' 'Glycolysis-Gluconeogenesis' 0.94 b0529 'methenyltetrahydrofolate cyclohydrolase' 'methylenetetrahydrofolate dehydrogenase NADP' 'Folate Metabolism' 'Folate Metabolism' 1.00 The upper bound of metabolic diversity Polymorphic communities consisting of strains with different metabolic...”
- Deletion of genes encoding cytochrome oxidases and quinol monooxygenase blocks the aerobic-anaerobic shift in Escherichia coli K-12 MG1655
Portnoy, Applied and environmental microbiology 2010 - “...frdABCDb sdhABCDb nuoA-nuoNb b4025 b3916 b2925 b2097 b3919 b1779 b2926 b2779 b1380 b3713 b1004 b4151-b4154 b0721-b0724 b2288-b2276 Phosphoglucose isomerase...”
- Identification of genome-scale metabolic network models using experimentally measured flux profiles
Herrgård, PLoS computational biology 2006 - “...EcoCyc ( http://biocyc.org/ECOLI/NEW-IMAGE?type=GENE&object=b1851 ) accession numbers for the genes discussed in this paper are tpi (b3919), ppc (b3956), pgi (b4025), pfkA (b3916), pta (b2297), lpdA (b0116), sucA (b0726), sucB (b0727), pgl (b0767), galU (b1236), fdnG (b1474), fdnH (b1475), fdnI (b1476), edd (b1851), nuoN (b2276), nuoM (b2277),...”
- Fitness of Escherichia coli during urinary tract infection requires gluconeogenesis and the TCA cycle
Alteri, PLoS pathogens 2009 - “...precursor 5.97 2.33E-05 TalA c2989 transaldolase 5.66 0.00021 XylA c4385 xylose isomerase 5.25 6.90E-07 TpiA c4871 triosephosphate isomerase 4.58 1.30E-07 SerA c3494 D-3-phosphoglycerate dehydrogenase 4.44 3.40E-09 SpeB c3522 agmantinase 4.06 3.90E-07 UxuA c5402 mannonate dehydratase 3.76 7.20E-03 NanA c3979 N-acetylneuraminate lyase subunit 3.64 4.50E-06 ArgG c3929...”
- RNA-seq analysis of the influence of anaerobiosis and FNR on Shigella flexneri
Vergara-Irigaray, BMC genomics 2014 - “...enzyme IIABC components 1.52 SF5M90T_1640 ydhC putative transport protein 1.51 0.69 SF5M90T_2359 beta-fructosidase 1.49 0.72 SF5M90T_3496 tpiA triosephosphate isomerase 1.45 SF5M90T_2405 ptsI PEP-protein phosphotransferase system enzyme I 1.42 SF5M90T_2808 fucI L-fucose isomerase 1.41 SF5M90T_2875 bglA 6-phospho-beta-glucosidase A 1.27 SF5M90T_3348 malP maltodextrin phosphorylase 1.16 0.78 SF5M90T_1107 ycfO...”
1aw1A / P50921 Triosephosphate isomerase of vibrio marinus complexed with 2- phosphoglycolate (see paper)
44% identity, 94% coverage
- Ligand: 2-phosphoglycolic acid (1aw1A)
Q7JNS1 Triosephosphate isomerase from Drosophila simulans
45% identity, 98% coverage
A5VI33 Triosephosphate isomerase from Limosilactobacillus reuteri (strain DSM 20016)
42% identity, 96% coverage
K2SJ45 Triosephosphate isomerase from Macrophomina phaseolina (strain MS6)
46% identity, 95% coverage
BH0055 triosephosphate isomerase from Borrelia hermsii DAH
42% identity, 98% coverage
- Identification of conserved antigens for early serodiagnosis of relapsing fever Borrelia
Lopez, Microbiology (Reading, England) 2009 - “...17, 23, 30 BH0476 43.4 41375 Fructose-bisphosphate aldolase 27 BH0445 40.0 3341 Triosephosphate isomerase 45 BH0055 27.7 211 Phosphoglycerate mutase 52, 53 BH0658 28.5 206323 Variable membrane proteins Variable large protein 5 26, 28, 3436, 38, 39 ABF21151 34.8 153443 Variable large protein C54silD 12, 13...”
- “...Ef-Tu, BH0476 94 97 97 97 Fructose-bisphosphate aldolase, BH0445 88 93 93 96 Triosephosphate isomerase, BH0055 77 86 86 91 Phosphoglycerate mutase, BH0658 83 90 91 96 Immune evasion protein Factor H-binding protein, EF411143* 61 Proteins with unknown function Hypothetical, FJ446703* 46 47 58 Hypothetical, BH0238*...”
L7UZA7 Triosephosphate isomerase from Dermatophagoides farinae
43% identity, 98% coverage
- Spirulina (Arthrospira platensis): Antiallergic Agent or Hidden Allergen? A Literature Review
Gromek, Foods (Basel, Switzerland) 2024 - “...triosephosphate isomerases have relevant sequence homology with the last detected spirulina protein. The first two (L7UZA7 and A0A088SAX2) are associated with Dermatophagoides farinae [ 58 , 59 ], and protein Q9FS79 is associated with Triticum aestivum . These proteins are not considered to be food allergens...”
- Allergen Delivery Inhibitors: A Rationale for Targeting Sentinel Innate Immune Signaling of Group 1 House Dust Mite Allergens through Structure-Based Protease Inhibitor Design
Zhang, Molecular pharmacology 2018 - “...Der f 24 KC669700 M9RZ95 Group 25, e.g., Der f 25 34 Triosephosphate isomerase KC305500.1 L7UZA7 Group 26, e.g., Der f 26 18 Myosin alkali light chain KM009996 b A0A088SAG5 b Group 27, e.g., Der f 27 48 Serpintrypsin inhibitor AIO08851 Group 28, e.g., Der f...”
KPHS_51710 triosephosphate isomerase from Klebsiella pneumoniae subsp. pneumoniae HS11286
43% identity, 96% coverage
- Use of a combined antibacterial synergy approach and the ANNOgesic tool to identify novel targets within the gene networks of multidrug-resistant Klebsiella pneumoniae
Lee, mSystems 2024 - “...(3-hydroxy butyryl-CoA dehydrogenase) distinctly decreased in the K56_Co_Che combination treatment condition, whereas KPHS_31180 (pyruvate kinase), KPHS_51710 (triosephosphate isomerase), and KPHS_51160 (phosphoglyceromutase) showed enhanced gene expression under the combination treatment. In the ( F ) glycolysis or gluconeogenesis pathway, KPHS_03180 (acetyl-CoA synthetase), KPHS_26520 (glyceraldehyde-3-phosphate dehydrogenase), and KPHS_40620...”
- “...) Decreased levels of KPHS_31520 (phosphoenolpyruvate synthase) and KPHS_31750 (6-phosphofructokinase), along with increased levels of KPHS_51710 (triosephosphate isomerase), KPHS_31180 (pyruvate kinase), and KPHS_51160 (phosphoglyceromutase), form a functionally related integrative network. ( G ) KPHS_23680 (enoyl-CoA hydratase), which is involved in phenylalanine metabolism, is linked to KPHS_23740....”
TPIS_DROME / P29613 Triosephosphate isomerase; TIM; Triose-phosphate isomerase; EC 5.3.1.1 from Drosophila melanogaster (Fruit fly) (see paper)
45% identity, 98% coverage
- catalytic activity: D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate (RHEA:18585)
subunit: Homodimer - Proteome-scale tagging and functional screening in mammalian cells by ORFtag
Nemčko, 2024 - Widespread regulatory specificities between transcriptional corepressors and enhancers inDrosophila
Jacobs, 2022 - Ik2/TBK1 and Hook/Dynein, an adaptor complex for early endosome transport, are genetic modifiers of FTD-associated mutant CHMP2B toxicity in Drosophila
Lu, Scientific reports 2020 - “...B52 P26686 43 2 0 Histone H4 His4 P84040 11 3 0 Triosephosphate isomerase Tpi P29613 27 2 0 Cytochrome c oxidase subunit 4 CoI4 Q9VIQ8 21 2 0 Hook and ctp are also strong genetic modifiers of mutant CHMP2B toxicity Because Hook has a specific...”
- Apocrine secretion in Drosophila salivary glands: subcellular origin, dynamics, and identification of secretory proteins
Farkaš, PloS one 2014 - “...mitochondrial Transferrin 2 Q9VTZ5 92.3 transport extracellular Trehalase Q9W2M2 67.7 metabolism cytoplasmic Triose phosphate isomerase P29613 26.6 metabolism cytoplasmic Tropomodulin O46231 41.4 cytoskeletal cytoplasmic Tropomyosin 1 P06754 39.3 cytoskeletal cytoplasmic -Tubulin84B P06603 49.9 cytoskeletal cytoplasmic -Tubulin85E (Tubulin alpha-2 chain) P06604 50.0 cytoskeletal cytoplasmic -Tubulin84D (Tubulin alpha-3...”
- On the origin of mitochondria: a genomics perspective
Andersson, Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2003 - “...J01366, AF063107, Q9M7R5, M87064, Y13387, U23081, P29613, P17751, M83294, AE000685, U28760, P27876, NCF000911, O08408, Q9Z520, AAL74288, AP002995/Q98ME7,...”
SNSL254_A4410 triosephosphate isomerase from Salmonella enterica subsp. enterica serovar Newport str. SL254
NP_462962 triosephosphate isomerase from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
Q8ZKP7 Triosephosphate isomerase from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
STM14_4906 triose-phosphate isomerase from Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S
41% identity, 99% coverage
tpi1 / CAD98875.1 triose phosphate isomerase from Klebsiella pneumoniae (see paper)
43% identity, 96% coverage
NP_788764 triose phosphate isomerase, isoform A from Drosophila melanogaster
45% identity, 71% coverage
- Structural and Genetic Studies Demonstrate Neurologic Dysfunction in Triosephosphate Isomerase Deficiency Is Associated with Impaired Synaptic Vesicle Dynamics.
Roland, PLoS genetics 2016 - GeneRIF: our findings are the first to identify, to our knowledge, a functional synaptic defect in TPI deficiency derived from molecular changes in the TPI dimer interface.
- Evidence of a triosephosphate isomerase non-catalytic function crucial to behavior and longevity.
Roland, Journal of cell science 2013 - GeneRIF: TPI sugarkill can be genetically complemented by TPI encoding a catalytically inactive enzyme.
- wasted away, a Drosophila mutation in triosephosphate isomerase, causes paralysis, neurodegeneration, and early death.
Gnerer, Proceedings of the National Academy of Sciences of the United States of America 2006 - GeneRIF: Mutation of wasted away, a recessive, hypomorphic mutation of triosephosphate isomerase (Tpi), highlights the essential protective role of triosephosphate isomerase.
PMI3205 triosephosphate isomerase from Proteus mirabilis HI4320
43% identity, 96% coverage
- Pathogenesis of <i>Proteus mirabilis</i> Infection
Armbruster, EcoSal Plus 2018 (secret) - Proteus mirabilis and Urinary Tract Infections
Schaffer, Microbiology spectrum 2015 - “...PMI0655 and talB PMI0006) had increased distances. Mutations in glycolysis ( pfkA PMI3203 and tpiA PMI3205) resulted in reduced swarming diameter. These mutations were rescued by complementation with the corresponding wild-type alleles or by addition of the missing biochemical intermediate to the growth medium. Specifically, the...”
- “...cr NR ( 134 ) pfkA PMI3203 6-phosphofructokinase NR cr NR ( 134 ) tpiA PMI3205 triosephosphate isomerase NR cr NR ( 134 ) Amino acids serC PMI0711 phosphoserine aminotransferase NR cr NR ( 56 ) cysJ PMI2250 sulfite reductase [NADPH] flavoprotein alpha-component NR cr c...”
H16_A1047 triose-phosphate isomerase from Cupriavidus necator H16
H16_A1047 triosephosphate isomerase from Ralstonia eutropha H16
42% identity, 98% coverage
- A closer look on the polyhydroxybutyrate- (PHB-) negative phenotype of Ralstonia eutropha PHB-4
Raberg, PloS one 2014 - “...H16_B2113 11 1 ThiJ putative intracellular protease/amidase/DJ-1/PfpI family H16_A0394 2 Tim triosephosphate isomerase (EC 5.3.1.1) H16_A1047 12 1 Succinyl-CoA:3-ketoacid-coenzyme A transferase subunit A (EC 2.8.3.5) H16_A1331 2 MenG2 demethylmenaquinone methyltransferase (EC 2.1.1.163) H16_B0348 13 1 MenG2 demethylmenaquinone methyltransferase (EC 2.1.1.163) H16_B0348 14 1 MenG2 demethylmenaquinone methyltransferase...”
A0A0S1U346 Triosephosphate isomerase from Amphioctopus fangsiao
44% identity, 98% coverage
PHATRDRAFT_50738 triosephosphate isomerase from Phaeodactylum tricornutum CCAP 1055/1
B7FT67 Triosephosphate isomerase from Phaeodactylum tricornutum (strain CCAP 1055/1)
41% identity, 86% coverage
- Proteomics to reveal metabolic network shifts towards lipid accumulation following nitrogen deprivation in the diatom Phaeodactylum tricornutum.
Yang, Journal of applied phycology 2014 - “...et al. 2011 ). In total, four glyceraldehyde 3-phosphate dehydrogenases (GAPDH; PHATRDRAFT_22122, PHATRDRAFT_32747, PHATRDRAFT_25308, and PHATRDRAFT_50738; Fig. 2 ) were identified, and all showed decreased expression following N. GAPDH is involved in gluconeogenesis, glycolysis, the phosphopentose shunt, and fatty acid biosynthesis by catalyzing the reversible oxidative...”
- Proteomic and biochemical responses to different concentrations of CO2 suggest the existence of multiple carbon metabolism strategies in Phaeodactylum tricornutum
Wu, Biotechnology for biofuels 2021 - “...B5Y3N7), phosphoglycerate kinase (PGK, Q9 M7P7, B7G6H0), glyceraldehyde-3-phosphate dehydrogenase (GAPDH, B7G5Q1), and triosephosphate isomerase (TIM, B7FT67), were upregulated under HC conditions and downregulated under LC conditions, indicating that HC promoted the activity of the Calvin cycle, while LC reduced the activity of the Calvin cycle. Glucose-6-phosphate...”
- Proteome response of Phaeodactylum tricornutum, during lipid accumulation induced by nitrogen depletion
Longworth, Algal research 2016 - “...Succinate dehydrogenase iron sulfur protein 5 2.59 B7FUU0 Transketolase 36 1.37 B7G5R3 Transketolase 10 1.58 B7FT67 Triosephosphate isomerase 6 1.42 B7G3C1 Triosephosphate isomerase 4 1.46 Fatty acid biosynthesis B7G1R8 3-oxoacyl-[acyl-carrier protein 11 1.71 B7GCM0 3-oxoacyl-[acyl-carrier-protein] synthase 10 1.51 B7G7H8 3R-hydroxyacyl-[acyl carrier protein] dehydrase 4 1.41 A0T0F8...”
TPIS_THET8 / Q5SJR1 Triosephosphate isomerase; TIM; TPI; Triose-phosphate isomerase; EC 5.3.1.1 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
40% identity, 98% coverage
- function: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P).
catalytic activity: D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate (RHEA:18585)
subunit: Homodimer.
CPn1063 Triosephosphate Isomerase from Chlamydophila pneumoniae CWL029
41% identity, 97% coverage
A4ZXC4 Triosephosphate isomerase from Apis mellifera
45% identity, 98% coverage
LIC12094 triosephosphate isomerase from Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130
42% identity, 98% coverage
Q17HW3 Triosephosphate isomerase from Aedes aegypti
45% identity, 98% coverage
Q38IW8 Triosephosphate isomerase from Glycine max
42% identity, 99% coverage
- Proteomics, physiological, and biochemical analysis of cross tolerance mechanisms in response to heat and water stresses in soybean
Katam, PloS one 2020 - “...malate dehydrogenase 43.9/6.47 33/5.5 L-malate dehydrogenase activity TCA process, Malate metabolic process 185 24 20 Q38IW8 Glyma15g04290 Triosephosphate isomerase 33.3/6.3 28/6.25 Triose-phosphate isomerase activity Metabolism, Glycolytic process 107 14 21 Q93XE6 Glyma20g38560 Chalcone flavone isomerase 1A 23.3/6.23 26/6.15 Flavonoids, chalcone isomerase activity Secondary metabolism 325 54...”
- Proteomic analysis reveals a role of melatonin in promoting cucumber seed germination under high salinity by regulating energy production.
Zhang, Scientific reports 2017 - “...7.05 0.00842 14.10 0.15009 Triosephosphate isomerase cytosolic B9GJN0 8.23 0.00026 11.29 0.00307 Triosephosphate isomerase cytosolic Q38IW8 10.64 0.00037 11.03 0.00048 Glucan endo- -beta-glucosidase 4 W9RG25 0.19 0.00031 0.29 0.04885 Lysosomal alpha-mannosidase isoform x1 A0A075CA98 4.21 0.00017 4.33 0.00378 Enolase A0A067JHW3 6.84 0.00003 9.15 0.00003 Phosphoglycerate kinase...”
- “...7.05 0.00842 14.10 0.15009 Triosephosphate isomerase cytosolic B9GJN0 8.23 0.00026 11.29 0.00307 Triosephosphate isomerase cytosolic Q38IW8 10.64 0.00037 11.03 0.00048 indicates increased proteins, and indicates significant decreased protein (fold change2 or2 and P value<0.05). indicates not detected. Melatonin regulates the cell elongation under salt stress In...”
PFLU_RS25840 triose-phosphate isomerase from Pseudomonas [fluorescens] SBW25
41% identity, 97% coverage
- Identification and Characterization of Domesticated Bacterial Transposases
Bertels, Genome biology and evolution 2017 - “...were P. fluorescens SBW25 peptide deformylase, Def (PFLU_RS00090), and P. fluorescens SBW25 triosephosphate isomerase TpiA (PFLU_RS25840). Query sequences for the ISs were ECIAI1_4438 from Escherichia coli IAI1 (IS 200 family) and ISEc 32 from E. coli S88 plasmid pECOS88 (IS 110 family, ECSMS35_RS25240). The sequence of...”
C5CBP6 Triosephosphate isomerase from Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / CCM 169 / CCUG 5858 / IAM 1056 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230)
44% identity, 95% coverage
GRMZM2G018177 uncharacterized protein LOC100194114 from Zea mays
44% identity, 99% coverage
- Altered nucleosome positions in maize haplotypes and mutants of a subset of SWI/SNF-like proteins
Stroud, Plant direct 2017 - “...B73 Ba1 GRMZM2G397518 Ba1_NP1 B73 Bap2 GRMZM2G152655 Bap2_NP1 B73 Gpc1 GRMZM2G046804 Gpc1_NP1 W22 1 Tpi3 GRMZM2G018177 Tpi3_NP1 B73 Cyc7 GRMZM2G310115 Cyc7_NP1 W22 The names and IDs of maize genes with demonstrated nucleosome position (NP) change between the B73 and W22 haplotypes are listed. The haplotype with...”
- “...Stc1 GRMZM2G177098 Stc1_NP1 chr106T11 chr127m1 W22 W22 Loss Loss 25.0 3 end M M Tpi3 GRMZM2G018177 Tpi3_NP1 chr106T11 W22 Gain NA b NA b W Tdy1 GRMZM2G321778 Tdy1_NP1 chr127m1 W22 Gain 33.3 77.7 3 end 5 end M 2 Bx1 GRMZM2G085381 Bx1_NP1 chr156m1 W22 Loss NA...”
- Developmental dynamics of Kranz cell transcriptional specificity in maize leaf reveals early onset of C4-related processes
Tausta, Journal of experimental botany 2014 - “...al. , 2007 ; Tomcal et al. , 2013 ), two are highly expressed (GRMZM2G030784, GRMZM2G018177) and three are expressed at a much lower level (~10 less) but still with a BS-enhanced ratio (GRMZM2G370275, GRMZM2G435244, GRMZM2G305211). The two more highly expressed BS-enriched TIMs are also homeologues,...”
LIMLP_10350 triose-phosphate isomerase from Leptospira interrogans serovar Manilae
42% identity, 98% coverage
Entcl_0092 triose-phosphate isomerase from [Enterobacter] lignolyticus SCF1
43% identity, 99% coverage
- Multi-time series RNA-seq analysis of Enterobacter lignolyticus SCF1 during growth in lignin-amended medium
Orellana, PloS one 2017 - “...D-glyceraldehyde 3-phosphate lyase, EC 4.1.2.13, encoded by Entcl_0829; (6) D-glyceraldehide-3-phosphate ketol-isomerase, EC 5.3.1.1, encoded by Entcl_0092; (7) glyceraldehyde-3-phosphate dehydrogenase, EC 1.2.1.12, encoded by Entcl_2214, Entcl_2615, and Entcl_2022; (8) phosphoglycerate kinase, EC 2.7.2.3, encoded by Entcl_0828; (9) phosphoglyceratemutase, EC 5.4.2.11, encoded by Entcl_3728, Entcl_0131, and Entcl_3075; (10)...”
O88328 Triosephosphate isomerase from Rattus norvegicus
44% identity, 98% coverage
XP_447161 hypothetical protein from Candida glabrata CBS 138
42% identity, 98% coverage
- Moonlighting proteins are variably exposed at the cell surfaces of Candida glabrata, Candida parapsilosis and Candida tropicalis under certain growth conditions
Karkowska-Kuleta, BMC microbiology 2019 - “...0.02312 gi|50,289,307 (XP_447084) uncharacterized protein CAGL0H06633g [ Candida glabrata ] phosphoenolpyruvate carboxykinase (Pck1) 0.03884 gi|50,289,459 (XP_447161) uncharacterized protein CAGL0H08327g [ Candida glabrata ] triosephosphate isomerase (Tpi1) 0.07053 0.03771 gi|50,289,591 (XP_447227) uncharacterized protein CAGL0H09878g [ Candida glabrata ] inorganic pirophosphatase (Ipp1) 0.03773 gi|50,290,317 (XP_447590) uncharacterized protein CAGL0I07843g...”
V6E02_12015 triose-phosphate isomerase from Thiobacter sp. AK1
41% identity, 100% coverage
- <i>Thiobacter aerophilum</i> sp. nov., a Thermophilic, Obligately Chemolithoautotrophic, Sulfur-Oxidizing Bacterium from a Hot Spring and Proposal of <i>Thiobacteraceae</i> fam. nov
Dukat, Microorganisms 2024 - “...chain (V6E02_11155), RubisCO small chain (V6E02_11160), phosphoglycerate kinase (V6E02_11035), NAD-dependent glyceraldehyde-3-phosphate dehydrogenase (V6E02_11030), triosephosphate isomerase (V6E02_12015), bifunctional fructose-/sedoheptulose-bisphosphate aldolase class II (V6E02_11045), bifunctional fructose-/sedoheptulose-bisphosphatase type I (V6E02_08490), transketolase (V6E02_11025), ribulose-phosphate 3-epimerase (V6E02_08935), ribose-5-phosphate isomerase A (V6E02_08820), and phosphoribulokinase (V6E02_04755). Assimilation of carbon dioxide via the Calvin...”
B4FNW1 Triosephosphate isomerase, cytosolic from Zea mays
NP_001140424 triosephosphate isomerase, cytosolic from Zea mays
P12863 Triosephosphate isomerase, cytosolic from Zea mays
43% identity, 99% coverage
- Differentially abundant proteins associated with heterosis in the primary roots of popcorn
Rockenbach, PloS one 2018 - “...ribosomal S15 2 20.0 23540.8 23639.4 38381.3 1.63 0.019 (+) Translation Guo et al .2013 B4FNW1 triosephosphate cytosolic 14 138.8 20680.5 14836.1 34631.0 1.95 0.041 (+) Small Molecule Metabolic Process Lpez-Castillo et al .2016 Q06XS2 lipoxygenase chloroplastic-like 22 168.4 17824.1 27251.7 34955.5 1.55 0.037 (+) Small...”
- “...chain were identified in the UENF/UEM01 hybrid ( Table 2 ): a cytosolic triosephosphate enzyme (B4FNW1) involved in gluconeogenesis and the glycolysis pathway [ 41 ]; a dihydrolipoamide S-acetyltransferase (Q9SWR9) subunit of the maize mitochondrial pyruvate dehydrogenase complex (PDC) [ 42 ]; and a NADH dehydrogenase...”
- Identification and characterization of lysine-rich proteins and starch biosynthesis genes in the opaque2 mutant by transcriptional and proteomic analysis
Jia, BMC plant biology 2013 - “...alpha 14 AAO63267 Legumin-like protein, complete 15 Q43247 Glyceraldehyde-3-phosphate dehydrogenase 16 Q43247 Glyceraldehyde-3-phosphate dehydrogenase 17 NP_001140424 triosephosphate isomerase 18 ACG35098 17.4kDa class I heat shock protein 3 19 P04713 Granule-bound starch synthase 1 2.5 1 20 P04713 Granule-bound starch synthase 1 2.1 21 P04713 Granule-bound starch...”
- “...Glyceroldehyde-3-phosphate dehydrogenase 1.6 36 NP_001149440 sorbitol dehydrogenase homolog1 2.7 37 ABA70761 sorbitol dehydrogenase 2.9 38 NP_001140424 triosephosphate isomerase, cytosolic 1.5 39 ACG35098 17.4kDa class I heat shock protein 3 1.2 40 NP_001140424 triosephosphate isomerase, cytosolic 1.6 1 Bold values indicate significant difference by ANOVA (p<0.05; n=3)....”
- Identification of cross-reactive IgE-binding proteins from Philippine allergenic grass pollen extracts
Castor, Asia Pacific allergy 2024 - “...(theoretical) UP/PSM/SC Mascot Protein Score 4 Fructokinase-2 Q6XZ78 35.5/5.58 4/16/23 582 9 Triosephosphate isomerase, cytosolic P12863 27/5.68 3/12/26 503 11 PMEI domain-containing protein A0A0P0XZJ5 19.3/7.93 1/70/61 2598 14 FAD-binding PCMH-type domain-containing protein (glycoprotein) A0A0E0HS70 58.3/9.2 16/31/34 1044 17 Haloacid dehalogenase-like hydrolase domain-containing protein A0A453QD66 27.2/5.08 1/1/6...”
- Proteomic Changes in Paspalum fasciculatum Leaves Exposed to Cd Stress
Salas-Moreno, Plants (Basel, Switzerland) 2022 - “...P50300 S-adenosylmethionine synthase 43.141 16.2849872 Pinus banksiana 10.1 10.0 Cytoplasm Carbohydrate and energy metabolism 39 P12863 Triosephosphate isomerase 27.008 38.3399209 Zea mays 1.5 1.2 Cytoplasm 40 P92549 ATP synthase subunit alpha 55.011 26.035503 Arabidopsis thaliana 0.8 9.6 Mitochondrion 41 P00056 Cytochrome c 12.005 39.6396396 Zea mays...”
- Antiproliferative and apoptotic effects of proteins from black seeds (Nigella sativa) on human breast MCF-7 cancer cell line.
Khurshid, BMC complementary medicine and therapies 2020 - “...P46520 66 26.3 10.1 5.5 Em protein H2 Q08000 58 44.1 9.9 5.5 Triosephosphate isomerase P12863 72 27.3 27.2 5.5 Thionin NsW1 C0HJH9 69 28.6 4.3 9.6 ADP-ribosylation factor GTPase-activating protein Q5W7F2 60 10.5 93.2 8.3 Late embryogenesis abundant protein 1 O49816 56 34.5 19.0 8.6...”
- Leaf proteome modulation and cytological features of seagrass Cymodocea nodosa in response to long-term high CO2 exposure in volcanic vents.
Piro, Scientific reports 2020 - “...P0C356 K02690 Photosystem I P700 chlorophyll a apoprotein A2 4.901 29.885 STA 82,672.8 ko00195 Photosynthesis P12863 K01803 Triosephosphate isomerase, cytosolic 4.827 28.386 STA 27,252.6 ko00010 Glycolysis/Gluconeogenesis O24592 K09840 9-cis-epoxycarotenoid dioxygenase 1, chloroplastic 4.805 27.953 STA 66,007.5 ko01110 Biosynthesis of seconday metabolites P0C2Z4 K02111 ATP synthase subunit...”
- A comparative glycoproteome study of developing endosperm in the hexose-deficient miniature1 (mn1) seed mutant and its wild type Mn1 in maize
Silva-Sanchez, Frontiers in plant science 2014 - “...Protein TOC75, chloroplastic from Oryza sativa (Q84Q83) 6.91 73.86 7 5 4 0.10 M 649 P12863 Triosephosphate isomerase, cytosolic 5.46 5.52 16.83 26.89 0.79 1.06 5 11 2 0.05 Love and Hanover, 2005 B6UB73 APx1-Cytosolic Ascorbate Peroxidase 5.65 27.39 4 9 0 0.04 626 B6SMQ5 Triosephosphate...”
- Genetic structure, linkage disequilibrium and signature of selection in Sorghum: lessons from physically anchored DArT markers.
Bouchet, PloS one 2012 - “...Auxin-induced protein PCNT115 2.E-132 86 o d l FI848068 0.39 (0.28) 0.80 (1.00) 3/Sb03g006130 6.2 P12863 Triosephosphate isomerase 2.E-128 97 o d l FI849137 0.39 (0.47) 0.91 (1.00) 3/Sb03g026270 0.3 Q8LBB2 SNF1-related protein kinase regulatory subunit gamma 1 6.E-42 62 o d l FI848736 0.56 (0.94)...”
TPIS_PROCL / F5A6E9 Triosephosphate isomerase; TIM; Methylglyoxal synthase; Triose-phosphate isomerase; Allergen Pro c 8.0101; EC 5.3.1.1; EC 4.2.3.3 from Procambarus clarkii (Red swamp crayfish) (see paper)
44% identity, 98% coverage
- function: Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis.
function: It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids.
catalytic activity: D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate (RHEA:18585)
catalytic activity: dihydroxyacetone phosphate = methylglyoxal + phosphate (RHEA:17937)
subunit: Homodimer.
AFUA_5G13450, Afu5g13450 triosephosphate isomerase from Aspergillus fumigatus Af293
Q4WVV5 Triosephosphate isomerase from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293)
44% identity, 95% coverage
- Biotinylated Surfome Profiling Identifies Potential Biomarkers for Diagnosis and Therapy of Aspergillus fumigatus Infection
Jia, mSphere 2020 - “...beta subunit Afu5g10550, putative dihydrolipoamide dehydrogenase Afu2g02100, putative aspartate aminotransferase Afu4g10410, and putative triosephosphate isomerase Afu5g13450 and several previously described surface proteins, including translational elongation factor 1 alpha Tef1 ( 30 ), peptidase DppV ( 31 ), 1,3-beta-glucanosyltransferase Bgt2 ( 32 ), and 14-3-3 protein ArtA...”
- “...M K38 D M Afu4g10410 Putative aspartate aminotransferase 429 K72 G M K85 D S Afu5g13450 Putative triosephosphate isomerase 249 K102 S K137 D K216 G M a Lysine residues of the protein detected with biotinylation in dormant (D), swollen (S), or germinating (G) conidia or...”
- Effects of amino acids on the lignocellulose degradation by Aspergillus fumigatus Z5: insights into performance, transcriptional, and proteomic profiles
Miao, Biotechnology for biofuels 2019 - “...in the proteome and transcriptome results remained consistent. Hexokinase (AFUA_2G05910, AFUA_7G04040), phosphoglucomutase (AFUA_3G11830), triosephosphate isomerase (AFUA_5G13450), phosphoglycerate mutase (AFUA_3G09290), phosphoglycerate kinase (AFUA_1G10350), enolase (AFUA_6G06770), and pyruvate kinase (AFUA_6G07430) also showed consistency between the two omics in the process of participating in glycolysis. In addition, there was...”
- The proteomic signature of Aspergillus fumigatus during early development
Cagas, Molecular & cellular proteomics : MCP 2011 - “...AFUA_3G07430 AFUA_1G11190 AFUA_3G11690 AFUA_6G06770 AFUA_5G13450 AFUA_3G08380 AFUA_4G13120 AFUA_4G07710 AFUA_5G09230 AFUA_1G11480 AFUA_3G11070 AFUA_6G06750...”
- “...P41746 Q4WB08 Q4WP70 AFUA_5G14680 AFUA_8G01670 AFUA_5G13450 AFUA_5G02910 AFUA_6G06750 AFUA_5G09230 AFUA_5G06680 AFUA_3G14540 Q4WYW9 Q4WW75 Q7Z7W6 Q4WVV5 Q4WEG3...”
- The proteomic signature of Aspergillus fumigatus during early development
Cagas, Molecular & cellular proteomics : MCP 2011 - “...-10 Q4WQK3 Q4WVI1 Q4WXZ8 Q4W9S8 Q4WWR9 Q4WX65 Q4WX73 Q4WVV5 Q4X1M0 Q4W9U9 P40292 Q4W9S6 Q4WDJ0 Q7Z8P9 Q4WX43 Q4WN39 Q4WDH2 Q4WNT7 Q4X1G3 Q4WSA0 Q4WEX6 Q4WNT6...”
- “...AFUA_6G06750 AFUA_5G09230 AFUA_5G06680 AFUA_3G14540 Q4WYW9 Q4WW75 Q7Z7W6 Q4WVV5 Q4WEG3 Q4WI29 Q4WUP8 Q4WTZ9 ORF Name UniProt ID katG enoA pdcA abr2 sodC...”
TP0537 triosephosphate isomerase (tpi) from Treponema pallidum subsp. pallidum str. Nichols
41% identity, 98% coverage
HI0678 triosephosphate isomerase (tpiA) from Haemophilus influenzae Rd KW20
42% identity, 91% coverage
Q9HGY8 Triosephosphate isomerase from Aspergillus oryzae (strain ATCC 42149 / RIB 40)
43% identity, 95% coverage
- iTRAQ-Based Quantitative Proteomic Analysis Reveals Proteomic Changes in Mycelium of Pleurotus ostreatus in Response to Heat Stress and Subsequent Recovery
Zou, Frontiers in microbiology 2018 - “...posadasii 2.02 1 0.035 0.301 D4AX50 Subtilisin-like protease 8 Arthroderma benhamiae 3.88 1 0.034 0.440 Q9HGY8 Triosephosphate isomerase Aspergillus oryzae 9.56 2 0.665 0.590 A6YRN9 Trehalose phosphorylase Pleurotus pulmonarius 30.72 20 0.859 0.652 P13228 Tryptophan synthase Neurospora crassa 4.52 1 1.046 0.525 C5FZ57 Putative aspergillopepsin A-like...”
- “...496.25 0.785 0.603 Agaricus bisporus Pyruvate kinase Q6BLA0 451.99 0.683 0.228 Debaryomyces hansenii Phosphoglycerate kinase Q9HGY8 271.03 0.665 0.590 Aspergillus oryzae Triosephosphate isomerase P17505 168.90 0.777 0.630 Saccharomyces cerevisiae Malate dehydrogenase P42894 101.22 0.887 0.607 Neocallimastix frontalis Enolase-EMP A8PDE3 90.58 0.469 1.253 Coprinopsis cinerea Acetyl-coenzyme A...”
- Metaproteomics reveals major microbial players and their biodegradation functions in a large-scale aerobic composting plant
Liu, Microbial biotechnology 2015 - “...Gluconeogenesis Lactobacillus delbrueckii Bacilli; Lactobacillales Hexokinase-2 P50521 Glycolysis / Gluconeogenesis Schizosaccharomyces pombe Schizosaccharomycetes Triosephosphate isomerase Q9HGY8 Glycolysis / Gluconeogenesis Aspergillus oryzae Eurotiomycetes Glyceraldehyde-3-phosphate dehydrogenase Q00584 Glycolysis / Gluconeogenesis Claviceps purpurea Sordariomycetes Phosphoenolpyruvate carboxykinase [GTP] A8L175 Glycolysis / Gluconeogenesis Frankia sp. Actinobacteria Aryl-phospho-beta-D-glucosidase BglC P42403 Glycolysis /...”
TPIS_YEAST / P00942 Triosephosphate isomerase; TIM; Triose-phosphate isomerase; EC 5.3.1.1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
P00942 triose-phosphate isomerase (EC 5.3.1.1) from Saccharomyces cerevisiae (see 8 papers)
YDR050C Tpi1p from Saccharomyces cerevisiae
NP_010335 triose-phosphate isomerase TPI1 from Saccharomyces cerevisiae S288C
42% identity, 98% coverage
- catalytic activity: D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate (RHEA:18585)
subunit: Homodimer. - Yeast Rim11 kinase responds to glutathione-induced stress by regulating the transcription of phospholipid biosynthetic genes
Yasukawa, Molecular biology of the cell 2024 - “...to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis 0.61 0.65 1.89 1.23 TPI1 YDR050C Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5 noncoding region;...”
- Ribonuclease selection for ribosome profiling
Gerashchenko, Nucleic acids research 2017 - “...slope in nuclease I treated samples. ( B ) Ribosomal coverage profiles of TPI1 gene (YDR050C) produced by various ribonucleases. Left-side panels show the coverage when the entire footprint length is used. Right-side panels show the coverage when only a single 3 end nucleotide of each...”
- Transcriptional profiling reveals molecular basis and novel genetic targets for improved resistance to multiple fermentation inhibitors in Saccharomyces cerevisiae
Chen, Biotechnology for biofuels 2016 - “...Term Acetic acid Furfural Acetic acid & furfural Carbohydrate metabolic process (GO:0005975) YBR001C, YBR105C, YDL055C, YDR050C, YER001W, YFL045C, YFL053W, YGL179C, YGR282C, YJL153C, YJR096W , YKL201C, YLL026W, YLR286C , YLR300W, YOL086C, YOR099W, YPL053C, YPR160W, YPR165W YEL040W, YFR053C, YGL156W, YGR043C, YGR256W, YJR096W , YLL026W , YLR286C , YML100W,...”
- “...YOL151W, YPL095C Nucleobase-containing small molecule metabolic process (GO:0055086) YBL022C, YBL098W, YCR021C , YDL055C, YDL234C, YDR011W, YDR050C, YDR135C, YDR214W, YDR502C, YER043C, YER070W, YFL045C, YGR209C, YGR281W, YKR080W, YLR043C, YLR180W, YLR231C, YMR120C, YMR300C, YNL112W, YNL220W, YOL086C, YOR128C, YOR153W, YOR184W, YOR328W, YPL036W, YPL058C YCR021C , YDR502C, YGR043C, YGR256W, YKL151C, YLR249W,...”
- Protein aggregation activates erratic stress response in dietary restricted yeast cells
Bhadra, Scientific reports 2016 - “...ATP synthase 25 Eno1/2 YGR254W Phosphopyruvate hydratase Eno1 58 Arp2 YDL029W Actin-Related Protein 62 Tpi YDR050C Triose phosphate isomerase 67 Utp21 YLR409C Subunit of U3-containing 90S preribosome and SSU processome complexes 71 Hom6 YJR139C Homoserine dehydrogenase 97 Fpr1 YNL135C Peptidyl-prolyl cis-trans isomerase (PPIase)...”
- CytoASP: a Cytoscape app for qualitative consistency reasoning, prediction and repair in biological networks
Kittas, BMC systems biology 2015 - “...unknown expression, based on the transcriptomics data and underlying network. Consider e.g. nodes YCL050C, YPL075W, YDR050C (2) in Fig. 2 . Expression of APA1 gene (YCL050C) is regulated by the carbon source and requires the protein GCR1 (YPL075W) [ 10 ]. GCR1 mutations substantially decrease the...”
- Quantitative nature of overexpression experiments
Moriya, Molecular biology of the cell 2015 - “...1,2358,595 (25.8) 5,141,175,549 (31.9) CDC19 YAL038W 404,162 (0.8) 31.8 500 12,864,113 (26.9) 6,432,056,484 (39.9) TPI1 YDR050C 395,237 (0.8) 68.5 248 27,054,398 (56.5) 6,709,490,697 (41.6) RPL9A YGL147C 265,169 (0.6) 6.2 191 1,642,828 (3.4) 313,780,172 (1.9) RPS12 YOR369C 258,298 (0.5) 6.2 143 1,611,136 (3.4) 230,392,526 (1.4) Total proteome...”
- Complementation of Yeast Genes with Human Genes as an Experimental Platform for Functional Testing of Human Genetic Variants
Hamza, Genetics 2015 - “...c DNA ligase found in the nucleus and mitochondria YDL205C HEM3 3145 HMBS Porphobilinogen deaminase YDR050C TPI1 b 7167 TPI1 Triose phosphate isomerase, abundant glycolytic enzyme YDR086C SSS1 23480 SEC61G Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) YDR208W MSS4 b 8394; 8395 PIP5K1A ; PIP5K1B c...”
- Improved production of a heterologous amylase in Saccharomyces cerevisiae by inverse metabolic engineering
Liu, Applied and environmental microbiology 2014 - “...Description M715 YBR018C YBR026C YBR120C YBR295W YKR105C YDL194W YDR050C YGR047C YGR083C YHL038C YKL148C GAL7 ETR1 CBP6 PCA1 NA SNF3 TPI1 TFC4 GCD2 CBP2 SDH1...”
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- Phenylpyrrole fungicides act on triosephosphate isomerase to induce methylglyoxal stress and alter hybrid histidine kinase activity.
Brandhorst, Scientific reports 2019 - GeneRIF: Phenylpyrrole fungicides act on triosephosphate isomerase to induce methylglyoxal stress and alter hybrid histidine kinase activity.
- Complex kinetics and residual structure in the thermal unfolding of yeast triosephosphate isomerase.
Labastida-Polito, BMC biochemistry 2015 - GeneRIF: temperature-induced unfolding of yeast TIM shows three kinetic phases
- Effects of a buried cysteine-to-serine mutation on yeast triosephosphate isomerase structure and stability.
Hernández-Santoyo, International journal of molecular sciences 2012 - GeneRIF: Cysteine-to-serine mutation in triosephosphate isomerase is associated with altered structure and stability.
- Triosephosphate isomerase: 15N and 13C chemical shift assignments and conformational change upon ligand binding by magic-angle spinning solid-state NMR spectroscopy.
Xu, Journal of molecular biology 2010 - GeneRIF: Information on most of the active-site residues involved in chemistry, including some that were not reported in a previous solution NMR study, such as the side-chain carbons of His95 of yeast triosephosphate isomerase, was obtained.
- The conserved salt bridge linking two C-terminal beta/alpha units in homodimeric triosephosphate isomerase determines the folding rate of the monomer.
Reyes-López, Proteins 2008 (PubMed)- GeneRIF: These results indicate that renaturation of yTIM occurs through a uni-bimolecular mechanism in which refolding of the monomer most likely begins at the C-terminal half of its polypeptide chain.
- Hydrophobic repacking of the dimer interface of triosephosphate isomerase by in silico design and directed evolution.
Peimbert, Biochemistry 2008 (PubMed)- GeneRIF: relative stabilities of different folding units are similar so that subtle alterations in their stability produce a total transformation of the folding pathway
- Substrate product equilibrium on a reversible enzyme, triosephosphate isomerase.
Rozovsky, Proceedings of the National Academy of Sciences of the United States of America 2007 - GeneRIF: The predominance of dihydroxyacetone phosphate (DHAP) on the enzyme supports a mechanism in which the initial proton abstraction in the reaction from DHAP to D-glyceraldehyde 3-phosphate is significantly slower than the subsequent chemical steps.
- Pressure and denaturants in the unfolding of triosephosphate isomerase: the monomeric intermediates of the enzymes from Saccharomyces cerevisiae and Entamoeba histolytica.
Vázquez-Pérez, Biochemistry 2007 (PubMed)- GeneRIF: unfolding and refolding of the Triose phosphate isomerase from baker's yeast (yTIM
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- CADEE: Computer-Aided Directed Evolution of Enzymes
Amrein, IUCrJ 2017 - “...residues Glu165 and His95 as acid/base catalysts ( S. cerevisiae enzyme residue numbering, UniProt ID P00942; DHAP C-atom numbering as in Supplementary Fig. S2). In the (rate-limiting) first reaction step of the isomerization of DHAP to GAP, Glu165 deprotonates C3 of DHAP to form the 2-enediolate,...”
- Vegemite Beer: yeast extract spreads as nutrient supplements to promote fermentation
Kerr, PeerJ 2016 (no snippet) - The RNA-binding protein repertoire of Arabidopsis thaliana.
Marondedze, Scientific reports 2016 (no snippet) - Relationship between Metabolic Fluxes and Sequence-Derived Properties of Enzymes
Zikmanis, International scholarly research notices 2014 (no snippet) - A model of yeast glycolysis based on a consistent kinetic characterisation of all its enzymes
Smallbone, FEBS letters 2013 - “...1.2 120000 TDH Tdh2p P00358 0 121000 TDH Tdh3p P00359 12700000 0.9 169000 TPI Tpi1p P00942 886000 0.8 207000 Table 4 Measured and predicted metabolite concentrations. Experimental values determined as described in Methods. Concentrations were calculated relative to an effective cytoplasmic volume of 5 fl (see...”
- The proteome response to amyloid protein expression in vivo
Gomes, PloS one 2012 - “...Transketolase 1 1.3 1.73E-03 CM P23254 550 322 296 5 TPIS Triosephosphateisomerase +1.4 1.61E-02 CM P00942 1296 432 342 5 TPIS Triosephosphate isomerase +1.5 7.15E-03 CM P00942 1669 906 750 7 TPIS Triosephosphate isomerase +1.4 6.10E-02 CM P00942 1671 513 443 4 TTR Human transthyretin P02766...”
- Regulation of xylose metabolism in recombinant Saccharomyces cerevisiae
Salusjärvi, Microbial cell factories 2008 - “...0.2 1.7 0.3 1.1 0.1 P23254 Tkl1p YPR074C transketolase -0.6 1.1 -1.0 -0.6 -0.5 -1.7 P00942 Tpi1p YDR050C triose-phosphate isomerase -1.1 0.2 0.5 -0.1 1.5 -0.3 P17649 Uga1p YGR019W 4-aminobutyrate transaminase -0.8 -0.1 1.4 0.2 2.2 0.3 Q12363 Wtm1p_a YOR230W transcriptional modulator 0.1 -0.1 1.7 0.2...”
- Top-down proteomics on a chromatographic time scale using linear ion trap fourier transform hybrid mass spectrometers
Parks, Analytical chemistry 2007 - “...P31787 Q3E754 P48606 Q12306 Q04401 Q03048 P14832 P40202 P00942 P07170 P25373 P53141 P33331 P38706 P04649 P40525 P26781 P53143 Q12344 P39741 P02406 P26782 P47913...”
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PP_4715 triose-phosphate isomerase from Pseudomonas putida KT2440
PP4715 triosephosphate isomerase from Pseudomonas putida KT2440
41% identity, 97% coverage
- Regulatory tasks of the phosphoenolpyruvate-phosphotransferase system of Pseudomonas putida in central carbon metabolism
Chavarría, mBio 2012 - “...Zwf-1, glucose 6-phosphate 1-dehydrogenase (PP_1022); Edd, phosphogluconate dehydratase (PP_1010); Eda, keto-hydroxyglutarate-aldolase (PP_1024); TpiA, triosephosphate isomerase (PP_4715); Gap, glyceraldehyde-3-phosphate dehydrogenase (PP_1009); Pgk, phosphoglycerate kinase (PP_4963); Pgm, phosphoglyceromutase (PP_5056); Eno, phosphopyruvate hydratase (PP_1612); PykA, pyruvate kinase (PP_1362); AceE, pyruvate dehydrogenase subunit E1 (PP_0339); AceF, dihydrolipoamide acetyltransferase (PP_0338); LpdG,...”
- Integrated analysis of gene expression and metabolic fluxes in PHA-producing Pseudomonas putida grown on glycerol
Beckers, Microbial cell factories 2016 - “...PP5040 Fructose-1,6-bisphosphatase 0.21 0.12 0.10 0.11 Fda PP4960 Fructose-1,6-bisphosphate aldolase 0.13 0.24 0.10 0.5 tpiA PP4715 Triosephosphate isomerase 0.82 0.47 0.10 0.93 gap1 PP1009 GAP dehydrogenase, type I 0.30 0.69 1.32 0.92 gap2 PP2149 GAP dehydrogenase, type II 0.14 0.06 0.10 0.42 pgk PP4963 Phosphoglycerate kinase...”
- Pseudomonas putida KT2440 Strain Metabolizes Glucose through a Cycle Formed by Enzymes of the Entner-Doudoroff, Embden-Meyerhof-Parnas, and Pentose Phosphate Pathways
Nikel, The Journal of biological chemistry 2015 - “...pgi-2 (PP4701, glucose-6-P isomerase), tpiA (PP4715, triose phosphate isomerase), eda (PP1024, 2-keto-3-deoxy-6-phosphogluconate aldolase), edd (PP1010,...”
- Production of medium chain length polyhydroxyalkanoate in metabolic flux optimized Pseudomonas putida
Borrero-de, Microbial cell factories 2014 - “...isomerase -0.5 0.0 fbp PP5040 Fructose-1,6-bisphosphatase 0.6 0.4 fda PP4960 Fructose-1,6-bisphosphate aldolase 0.9 0.1 tpiA PP4715 Triosephosphate isomerase 0.8 0.6 gap1 PP1009 GAP dehydrogenase, type I -1.2 -0.4 gap2 PP2149 GAP dehydrogenase, type II 0.2 0.3 pgk PP4963 Phosphoglycerate kinase 0.2 0.1 pgm PP5056 Phosphoglyceromutase 0.4...”
- “...isomerase -0.4 0.0 fbp PP5040 Fructose-1,6-bisphosphatase 0.3 -0.1 fda PP4960 Fructose-1,6-bisphosphate aldolase 0.6 -0.1 tpiA PP4715 Triosephosphate isomerase 0.4 0.5 gap1 PP1009 GAP dehydrogenase, type I -0.4 -0.2 gap2 PP2149 GAP dehydrogenase, type II -0.3 -0.2 pgk PP4963 Phosphoglycerate kinase 0.1 0.0 pgm PP5056 Phosphoglyceromutase 0.5...”
- The metabolic response of P. putida KT2442 producing high levels of polyhydroxyalkanoate under single- and multiple-nutrient-limited growth: highlights from a multi-level omics approach
Poblete-Castro, Microbial cell factories 2012 - “...-5.3 -4.0 PP0557 Acetoin catabolism regulatory protein -3.4 -3.6 PP2149 Glyceraldehyde 3-phospate dehydrogenase 1.5 -3.7 PP4715 Triosephosphate isomerase 1.9 -3.3 PP4737 D-lactate dehydrogenase putative -2.6* -3.1 PP0545 Aldehyde dehydrogenase family protein -1.9 -3.1 PP1083 Bacterioferritin-associated ferredoxin putative 1.4 2.9 PP3071 Acetoacetyl-CoA synthetase putative 1.1 -2.6 PP4736...”
- Genome-scale reconstruction and analysis of the Pseudomonas putida KT2440 metabolic network facilitates applications in biotechnology
Puchałka, PLoS computational biology 2008 - “...Max Limit Sim WT WT WT l -Serine 11.47 22.26 0.83 11.16 1 Triose-phosphate isomerase PP4715 d -Fructose 7.7 29.74 0.83 3.5 6-Phosphoglucono lactonase PP1023 2 Glucose dehydrogenase (membrane) PP1444 d -Glucose 7.05 28.51 0.83 4.17 6-Phosphoglucono lactonase PP1023 3 Isocitrate dehydrogenase PP4011 or PP4012 l...”
PA4748 triosephosphate isomerase from Pseudomonas aeruginosa PAO1
PA14_62830 triosephosphate isomerase from Pseudomonas aeruginosa UCBPP-PA14
40% identity, 97% coverage
- <i>Pseudomonas aeruginosa</i> transcriptome analysis of metal restriction in <i>ex vivo</i> cystic fibrosis sputum
Neff, Microbiology spectrum 2024 - “...protein N Y PA4468 sodA Superoxide dismutase Y N PA3006 psrA Transcriptional regulator Y N PA4748 tpiA Triosephosphate isomerase Y N PA4525 pilA Type IV major pilin protein PilA N Y PA2685 vgrG1c Type VI secretion system spike protein Y N Of 18 key genes that...”
- The Breadth and Molecular Basis of Hcp-Driven Type VI Secretion System Effector Delivery
Howard, mBio 2021 - “...Short-chain dehydrogenase 27.4 PA0075 PppA 5.8 1.44 Represses H1-T6SS 25.9 PA5220 5.3 1.32 Hypothetical 30.5 PA4748 TpiA 5.3 2.46 Triosephosphate isomerase 25.6 PA0895 AruC 5 1.73 Succinylornithine transaminase/acetylornithine aminotransferase 43.7 PA3471 MaeA 4.8 2.41 NAD-dependent malic enzyme 62.4 PA1588 SucC 4.8 2.73 Succinate-CoA ligase (ADP-forming) subunit...”
- Traditional Chinese Medicine Tanreqing Inhibits Quorum Sensing Systems in Pseudomonas aeruginosa
Yang, Frontiers in microbiology 2020 - “...kinase PA4443 cysD 2.1 1.1 + ATP sulfurylase small subunit PA3181 1.6 + 2-Keto3deoxy-6-phosphogluconate aldolase PA4748 tpiA 1.2 Triosephosphate isomerase PA3562 fruI 1.3 Phosphotransferase system transporter enzyme I, FruI Energy metabolism PA0519 nirS 1.7 1.9 Nitrite reductase precursor PA0521 2.0 Probable cytochrome c oxidase subunit PA0523...”
- Deciphering the Resistome of the Widespread Pseudomonas aeruginosa Sequence Type 175 International High-Risk Clone through Whole-Genome Sequencing
Cabot, Antimicrobial agents and chemotherapy 2016 - “...rpoN ampD PA4597 PA4598 PA4599 oprJ mexD mexC PA4700 PA4748 PA4773 PA4774 PA4777 PA4964 PA5000 PA5038 PA5045 PA5199 PA5200 PA5235 PA5297 PA5366 PA5471 mrcB tpiA...”
- Network-assisted investigation of virulence and antibiotic-resistance systems in Pseudomonas aeruginosa
Hwang, Scientific reports 2016 - “...antibiotic-resistant genes. From the interaction-bias analysis, we found that six ( PA0338, PA2023, PA4222, PA4223, PA4748 , and PA5000 ) of these 13 genes (46%) switch their interaction-bias towards the same direction of mutational effect between different drug conditions ( Fig. 4B ), which is a...”
- Localization of DING proteins on PstS-containing outer-surface appendages of Pseudomonas aeruginosa
Shah, FEMS microbiology letters 2014 - “...the ABI 7900HT System using SYBR Green qPCR SuperMix-UDG (Invitrogen), cDNA, and respective primers: for PA4748 gene, forward primer PA4748-F 5 AACAAGCAAGGCGGCATCACA 3 and reverse primer PA4748-R 5 TGCACGGTACGCATTCCAGTGT 3; for PstS PA5369 and PstS MDR25, forward primer PstS-F 5 CTGCCGGAATATCAGAAAGC 3 and reverse primer PstS-R...”
- “...density of 9095% confluence. Gene expression was estimated relative to the expression of housekeeping gene PA4748, encoding triose phosphate isomerase (Zaborin etal ., 2009 ). There was no significant difference in pstS expression between PA14 and MDR25 strains; however, the expression of DING in MDR25 was...”
- Phosphate-containing polyethylene glycol polymers prevent lethal sepsis by multidrug-resistant pathogens
Zaborin, Antimicrobial agents and chemotherapy 2014 - “...example: 2[Ct(pstS treatment PstS control) Ct(PA4748 treatment PA4748 control)]. Average and standard deviation values (Microsoft Excel) of three biological...”
- Emergence of the P2 phenotype in Pseudomonas aeruginosa PAO1 strains involves various mutations in mexT or mexF
Luong, Journal of bacteriology 2014 - “...was normalized to expression of the housekeeping gene PA4748 as previously described (30). Primers used were designed with Primer3 software. Sequencing of mexT...”
- More
- Glycerol metabolism impacts biofilm phenotypes and virulence in Pseudomonas aeruginosa via the Entner-Doudoroff pathway
Pan, mSphere 2024 - “...metabolism pathway, namely energy production and anabolism. We deleted fda ( PA14_07230 ), tpiA ( PA14_62830 ), or edd ( PA14_22910 ), each of which encodes a key enzyme in glycerol metabolism: anabolic production of fructose/glucose, direct breakdown of DHAP and use in the TCA cycle,...”
- “...MTC2685 fda ( PA14_07230 ) PA14 with markerless fda deletion This study MTC2686 tpiA ( PA14_62830 ) PA14 with markerless tpiA deletion This study MTC2687 edd ( PA14_22910 ) PA14 with markerless edd deletion This study MTC2783 edd attB :: edd PA14 with markerless edd deletion...”
- Pseudomonas aeruginosa core metabolism exerts a widespread growth-independent control on virulence
Panayidou, Scientific reports 2020 - “...) 43 Glycine, serine and threonine metabolism (pau00260) PA14_65560 ( serB ) 44 Glycolysis/Gluconeogenesis (pau00010) PA14_62830 ( tpiA ) *: Found attenuated in both assays (pricking and feeding); NT: Not Tested. Moreover, we sought to examine the 78 metabolic mutant strains during initial colonization, to identify...”
- Loss of the Two-Component System TctD-TctE in Pseudomonas aeruginosa Affects Biofilm Formation and Aminoglycoside Susceptibility in Response to Citric Acid
Taylor, mSphere 2019 - “...protein S21 2.48 PA14_63110 2.48 PA14_14610 2.49 PA14_63150 pmrA Two-component regulator system response regulator 2.49 PA14_62830 tpiA Triosephosphate isomerase 2.53 PA14_61820 2.55 PA14_09040 rplO 50S ribosomal protein L15 2.58 PA14_65180 rpsF 30S ribosomal protein S6 2.58 PA14_15980 rimM 16S rRNA processing protein 2.59 PA14_73410 2.62 PA14_58570...”
Q45XG1 Triosephosphate isomerase from Schistosoma turkestanicum
43% identity, 96% coverage
SPC_4187 triosephosphate isomerase from Salmonella enterica subsp. enterica serovar Paratyphi C strain RKS4594
41% identity, 97% coverage
- Antibacterial Components and Modes of the Methanol-Phase Extract from Commelina communis Linn
Liu, Plants (Basel, Switzerland) 2023 - “...SPC_4566 0.241 Fructose-1-bisphosphatase SPC_4282 0.417 Glucose-6-phosphate isomerase SPC_1226 2.146 Glucose-specific PTS system enzyme IIA component SPC_4187 2.296 Triosephosphate isomerase SPC_1980 2.76 Alcohol dehydrogenase SPC_2451 3.023 Glyceraldehyde-3-phosphate dehydrogenase SPC_3111 3.382 6-phospho-beta-glucosidase SPC_2543 5.68 PTS system glucose-specific IIBC component Oxidative phosphorylation SPC_0730 0.057 Succinate dehydrogenase cytochrome b556 small...”
B7FSI3 Triosephosphate isomerase/glyceraldehyde-3-phosphate dehydrogenase from Phaeodactylum tricornutum (strain CCAP 1055/1)
PHATRDRAFT_25308 triosephosphate isomerase/glyceraldehyde-3-phosphate dehydrogenase precursor from Phaeodactylum tricornutum CCAP 1055/1
44% identity, 39% coverage
- Metabolomic, proteomic and lactylated proteomic analyses indicate lactate plays important roles in maintaining energy and C:N homeostasis in Phaeodactylum tricornutum
Huang, Biotechnology for biofuels and bioproducts 2022 - “...0.02 0.60 0.04 Calvin cycle, glycolysis 2 B7FSQ0 Triosephosphate isomerase 0.49 0.12 0.33 0.00 3 B7FSI3 Glyceraldehyde 3-phosphate dehydrogenase 0.79 0.13 0.57 0.00 5 B7G938 Phosphoglycerate kinase 0.79 0.11 0.69 0.00 8 B7FSI4 Glyceraldehyde 3-phosphate dehydrogenase 0.72 0.16 0.50 0.01 19 B7G5G4 Phosphoglycerate kinase 0.80 0.23...”
- Proteomics to reveal metabolic network shifts towards lipid accumulation following nitrogen deprivation in the diatom Phaeodactylum tricornutum.
Yang, Journal of applied phycology 2014 - “...tricornutum (Santos et al. 2011 ). In total, four glyceraldehyde 3-phosphate dehydrogenases (GAPDH; PHATRDRAFT_22122, PHATRDRAFT_32747, PHATRDRAFT_25308, and PHATRDRAFT_50738; Fig. 2 ) were identified, and all showed decreased expression following N. GAPDH is involved in gluconeogenesis, glycolysis, the phosphopentose shunt, and fatty acid biosynthesis by catalyzing the...”
B5XB51 Triosephosphate isomerase from Salmo salar
44% identity, 98% coverage
TPIS_ENTH1 / O02611 Triosephosphate isomerase; EhTIM; Triose-phosphate isomerase; EC 5.3.1.1 from Entamoeba histolytica (strain ATCC 30459 / HM-1:IMSS / ABRM) (see 2 papers)
O02611 triose-phosphate isomerase (EC 5.3.1.1) from Entamoeba histolytica (see 2 papers)
EHI_056480, XP_650725 triosephosphate isomerase from Entamoeba histolytica HM-1:IMSS
A0A5K1V873 Triosephosphate isomerase from Entamoeba histolytica
39% identity, 95% coverage
B7Q3K7 Triosephosphate isomerase from Ixodes scapularis
42% identity, 98% coverage
A5AZX9 Triosephosphate isomerase, cytosolic from Vitis vinifera
42% identity, 99% coverage
APA386B_2746 triose-phosphate isomerase from Acetobacter pasteurianus 386B
40% identity, 100% coverage
A5A6F9 Triosephosphate isomerase from Schistosoma haematobium
42% identity, 96% coverage
B7G3C1 Triosephosphate isomerase from Phaeodactylum tricornutum (strain CCAP 1055/1)
41% identity, 94% coverage
- Proteomic and biochemical responses to different concentrations of CO2 suggest the existence of multiple carbon metabolism strategies in Phaeodactylum tricornutum
Wu, Biotechnology for biofuels 2021 - “...B7GDK9), fructose-1,6-diphosphate aldolase (FBAase, Q84X64, Q84XB5, B7GE67), aldolase (B7FRC1, B7G4R3), triose phosphate isomerase (TIM, B7FSQ0, B7G3C1), GAPDH (Q9M7R3, B7FSI4), PGK (B8LCF8, B7G938), phosphoglycerate mutase (PGAM, B7GEI2, B7FU06), plastic enolase (B7GEF2), pyruvate kinase (PK, Q2TSX0, Q2TSW9) and pyruvate dehydrogenase complex-related proteins (B7FZN6, B7FZE1, B7GDA9) were upregulated under...”
- “...2 , under LC cultivation, the expression of FBAase (Q84X64, Q84XB5), aldolase (B7FRC1, B7G4R3), TIM (B7G3C1), and GAPDH (Q9M7R3, B7FSI4) was significantly increased, and PGK (B7G938), PGM (B7FU06), enolase (B7GEF2), PK (B7FZG8, Q2TSW9) and pyruvate dehydrogenase complex-related proteins (PDH, B7FZE1, B7GDA9) were upregulated, while the expression...”
- Proteome response of Phaeodactylum tricornutum, during lipid accumulation induced by nitrogen depletion
Longworth, Algal research 2016 - “...5 2.59 B7FUU0 Transketolase 36 1.37 B7G5R3 Transketolase 10 1.58 B7FT67 Triosephosphate isomerase 6 1.42 B7G3C1 Triosephosphate isomerase 4 1.46 Fatty acid biosynthesis B7G1R8 3-oxoacyl-[acyl-carrier protein 11 1.71 B7GCM0 3-oxoacyl-[acyl-carrier-protein] synthase 10 1.51 B7G7H8 3R-hydroxyacyl-[acyl carrier protein] dehydrase 4 1.41 A0T0F8 Acyl carrier protein 2 1.96...”
M1CNK1 Triosephosphate isomerase, cytosolic from Solanum tuberosum
43% identity, 99% coverage
- Analysis of Stress Response Genes in Microtuberization of Potato <i>Solanum tuberosum</i> L.: Contributions to Osmotic and Combined Abiotic Stress Tolerance
Herrera-Isidron, Plants (Basel, Switzerland) 2024 - “...Histone H3.2-like), PGSC0003DMT400062986 (M1C9X0 ENO1 Enolase 1), PGSC0003DMT400071725 (M1CP75 RPL4 60S ribosomal protein L4-1-like), PGSC0003DMT400071330 (M1CNK1 TPI Triosephosphate isomerase). Blue diamonds (duplications or introgressions). Red circles (speciations). Black circles without lines (losses). Figure 5 Quantitative PCR analysis of the stolon explants producing MTs of seventeen selected...”
- “...49 , 50 , 51 , 52 , 53 , 54 , 55 ] PGSC0003DMT400071330 M1CNK1 TPI DOMc Triosephosphate isomerase [ 56 , 57 , 58 , 59 , 60 , 61 ] PGSC0003DMT400071725 M1CP75 RPL4 DOMc 60S ribosomal protein L4 [ 62 , 63 ,...”
FTT_0080 triosephosphate isomerase from Francisella tularensis subsp. tularensis SCHU S4
38% identity, 98% coverage
TIM / PDB|1M6J_A triosephosphate isomerase; EC 5.3.1.1 from Entamoeba histolytica (see paper)
39% identity, 94% coverage
y0052 triosephosphate isomerase from Yersinia pestis KIM
YPO0085 triosephosphate isomerase from Yersinia pestis CO92
42% identity, 96% coverage
- Functional characterization of Yersinia pestis aerobic glycerol metabolism
Willias, Microbial pathogenesis 2014 - “...DHAP serve as precursors for phospholipid biosynthesis [ 7 , 8 ]. Alternately, the TpiA (y0052) triose phosphate isomerase can convert DHAP into glyceraldehyde-3-phosphate, thereby enabling the glycolytic catabolism of glycerol [ 9 ]. The inability for biovar Orientalis isolates to ferment glycerol is presumed to...”
- Transcriptomic studies and assessment of Yersinia pestis reference genes in various conditions
Koch, Scientific reports 2019 - “...glutamine synthetase Fw GCTGAACATGTTTTGACGATGCT Rv TGCTCTTTCCCTTTGGTATCAGT gmk YPO0040 guanylate kinase Fw TTTTCATCTTGCCGCCATC Rv GATAACTTCTTCGCTATCCTG tpiA YPO0085 triosephosphate isomerase Fw ATCCGTGACCATATCGCCAAG Rv TTTCAGTGATGCACCGCCAAC cysG YPO0158 uroporphyrin III C-methyltransferase Fw GAAAAGTTGCTGACCCACGAC Rv TGCACCGACCAACACCAC rpsL YPO0200 30S ribosomal protein S12 Fw ACTAACGGTTTTGAAGTCAC Rv TCTTTAACACGACCGCCAC rpoA YPO0234 DNA-directed RNA polymerase,...”
sS8_1782 triose-phosphate isomerase from Methylocaldum marinum
39% identity, 98% coverage
- Possible cross-feeding pathway of facultative methylotroph Methyloceanibacter caenitepidi Gela4 on methanotroph Methylocaldum marinum S8
Takeuchi, PloS one 2019 - “...all Calvin-Benson-Bassham cycle genes, such as ribulose-1,5- bisphosphate carboxylase (sS8_2432), phosphoglycerate kinase (sS8_4941), glyceraldehyde-3-phosphate dehydrogenase (sS8_1782), triosephosphate isomerase (sS8_0238), fructose-1,6-bisphosphate aldolase (sS8_1130), transketolase (sS8_1131), ribulose-phosphate 3-epimerase (sS8_ 2460) and phosphoribulokinase (sS8_4630). NAD-dependent FDH ( fdhA1 , B1 , C1 , D1 and E1 ; sS8_03120316) and...”
Q6T379 Triosephosphate isomerase, cytosolic from Solanum chacoense
43% identity, 99% coverage
TPIS_SCYPA / A0A1L5YRA2 Triosephosphate isomerase; TIM; Allergen Scy p 8; Methylglyoxal synthase; Triose-phosphate isomerase; Allergen Scy p 8.0101; EC 5.3.1.1; EC 4.2.3.3 from Scylla paramamosain (Mud crab) (see 2 papers)
43% identity, 98% coverage
- function: Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis.
function: It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids.
catalytic activity: D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate (RHEA:18585)
catalytic activity: dihydroxyacetone phosphate = methylglyoxal + phosphate (RHEA:17937)
subunit: Homodimer.
TGME49_233500 triose-phosphate isomerase TPI-II from Toxoplasma gondii ME49
41% identity, 67% coverage
LOC107804179 triosephosphate isomerase, cytosolic-like from Nicotiana tabacum
44% identity, 100% coverage
TPI / GI|2143243 triosephosphate isomerase; EC 5.3.1.1 from Entamoeba histolytica (see paper)
39% identity, 94% coverage
B0LT90 Triosephosphate isomerase, cytosolic from Oryza coarctata
43% identity, 99% coverage
- Wild and Cultivated Species of Rice Have Distinctive Proteomic Responses to Drought
Hamzelou, International journal of molecular sciences 2020 - “...protease family protein 0.7 Aspartic proteinase ( Oryza sativa ) 98% Xylanase inhibitor N-terminal 9 B0LT90 Triosephosphate isomerase LOC_Os01g05490.1 triosephosphate isomerase, cytosolic 0.7 - - Triosephosphate isomerase 10 O04432 Glycine-rich protein LOC_Os12g43600.1 RNA recognition motif-containing protein 1.4 - - RNA recognition motif (RRM, RBD, or RNP...”
- Protein profile of Beta vulgaris leaf apoplastic fluid and changes induced by Fe deficiency and Fe resupply
Ceballos-Laita, Frontiers in plant science 2015 - “...C nCS Translation CARBON METABOLISM (27) 4 Enolase Q43130 nCS Glycolytic process 4 Triosephosphate isomerase B0LT90, K4FXE7, P48496 , , C , nCS, nCS Glycolytic process 11 Fructose-bisphosphate aldolase F1AHC9, O04975, Q6RSN7 C, , nCS, nCS, Glycolytic process 1 2,3-Bisphosphoglycerate-independent phosphoglycerate mutase Q42908 Glycolytic process 1...”
FTL_1780 triosephosphate isomerase from Francisella tularensis subsp. holarctica
38% identity, 98% coverage
Q589R5 Triosephosphate isomerase from Oryzias latipes
41% identity, 98% coverage
- Analysis of Proteins Associated with Quality Deterioration of Grouper Fillets Based on TMT Quantitative Proteomics during Refrigerated Storage.
Zhang, Molecules (Basel, Switzerland) 2019 - “...protein) and Q90YT6 (60S ribosomal protein L32) were potential markers for pH. P51903 (Phosphoglycerate kinase), Q589R5 (Triosephosphate isomerase) and Q90339 (Myosin heavy chain) were closely related with centrifugal loss. The proteins which contributed to the color change were P50143 (T-complex protein 1 subunit gamma), P06238 (Alpha-2-macroglobulin),...”
- “...Q90339 (Myosin heavy chain). Finally, P20810 (Calpastatin), Q90XG0 (Triose phosphate isomerase B), P08249 (Malate dehydrogenase), Q589R5 (Triosephosphate isomerase), Q9I8F9 (Heat shock 70 kDa protein 1), A2ASS6 (Titin), Q90339 (Myosin heavy chain), P23239 (Desmin) and A7E2Y1 (Myosin-7B) were potential markers for texture. This study could help to...”
A8B3A8 triose-phosphate isomerase (EC 5.3.1.1) from Rhipicephalus microplus (see paper)
41% identity, 98% coverage
4ff7A / P00942 Structure of c126s mutant of saccharomyces cerevisiae triosephosphate isomerase (see paper)
42% identity, 98% coverage
- Ligand: 2-phosphoglycolic acid (4ff7A)
K4FXE7 Triosephosphate isomerase, cytosolic from Capsicum annuum
43% identity, 99% coverage
- Apoplast proteomic analysis reveals drought stress-responsive protein datasets in chilli (Capsicum annuum L.)
Jaswanthi, Data in brief 2019 - “...(T/C) S.NO Accession Description MW [kDa]/calc.pI Abundance Ratio: (T/C) 1 A0A1U8E5V7 beta-xylosidase 85.6/8.06 0.684 17 K4FXE7 Triose phosphate isomerase 27.1/5.99 100 2 A0A1U8G957 Peroxidase 34.4/8.19 2.095 18 A0A1U8HJ07 Malate dehydrogenase 36.1/8.9 0.059 3 A0A1U8FME6 Acidic endochitinase Q 27.6/7.12 1.304 19 A0A1U8GJW9 aspartyl protease 46.3/8 100 4...”
- Protein profile of Beta vulgaris leaf apoplastic fluid and changes induced by Fe deficiency and Fe resupply.
Ceballos-Laita, Frontiers in plant science 2015 - “...nCS Translation CARBON METABOLISM (27) 4 Enolase Q43130 nCS Glycolytic process 4 Triosephosphate isomerase B0LT90, K4FXE7, P48496 , , C , nCS, nCS Glycolytic process 11 Fructose-bisphosphate aldolase F1AHC9, O04975, Q6RSN7 C, , nCS, nCS, Glycolytic process 1 2,3-Bisphosphoglycerate-independent phosphoglycerate mutase Q42908 Glycolytic process 1 Phosphoglucomutase...”
K0E682 Triosephosphate isomerase from Penaeus vannamei
42% identity, 98% coverage
5eywA / K0E682 Crystal structure of litopenaeus vannamei triosephosphate isomerase complexed with 2-phosphoglycolic acid (see paper)
42% identity, 98% coverage
- Ligand: 2-phosphoglycolic acid (5eywA)
Q27775 Triosephosphate isomerase from Schistosoma japonicum
41% identity, 96% coverage
W7MA30 Triosephosphate isomerase from Gibberella moniliformis (strain M3125 / FGSC 7600)
43% identity, 100% coverage
- ITRAQ-based quantitative proteomic analysis of Fusarium moniliforme (Fusarium verticillioides) in response to Phloridzin inducers.
Zhang, Proteome science 2021 - “...2 down-regulated and 4 up-regulated. Moreover, it was found that the differentially expressed proteins W7N5X1, W7MA30, W7M3M6, and W7MPI9, which collectively show significantly up-regulation, participate in 19 metabolic pathways in total, and the differentially expressed differentially-formed proteins W7LNK6, W7M651, participate in 13 metabolic pathways. Fig. 5...”
B5YLS7 Triosephosphate isomerase from Thalassiosira pseudonana
41% identity, 91% coverage
TPIS_CAEEL / Q10657 Triosephosphate isomerase; TIM; Methylglyoxal synthase; Triose-phosphate isomerase; EC 5.3.1.1; EC 4.2.3.3 from Caenorhabditis elegans (see paper)
Q10657 triose-phosphate isomerase (EC 5.3.1.1) from Caenorhabditis elegans (see paper)
42% identity, 98% coverage
LOC103863161 triosephosphate isomerase, cytosolic from Brassica rapa
42% identity, 99% coverage
Q1MTI4 Triosephosphate isomerase A from Danio rerio
43% identity, 98% coverage
- Dietary Creatine Supplementation in Gilthead Seabream (Sparus aurata): Comparative Proteomics Analysis on Fish Allergens, Muscle Quality, and Liver
Schrama, Frontiers in physiology 2018 - “...synthase OS Danio rerio 504 47,099/46,671 6.46/5.5 5 7 0.01 0.0112 1.32 CR5>CR2> CR8>CTRL 1,013 Q1MTI4 Triosephosphate isomerase A OS Danio rerio 2,170 26,836/26,776 4.72/4.7 6 25 0.002 0.0023 2.03 CR2>CR5> CR8>CTRL 1,214 G3PDP5 Uncharacterized protein OS Gasterosteus aculeatus [after blast on 28-04-2017 bifunctional protein GlmU-like...”
- BD SIMULATIONS OF THE IONIC STRENGTH DEPENDENCE OF THE INTERACTIONS BETWEEN TRIOSE PHOSPHATE ISOMERASE AND F-ACTIN.
Schmidt, Journal of undergraduate chemistry research 2010 - “...on the primary amino acid sequence in the Uniprot Data Base (primary accession number (PAN), Q1MTI4 ( 44 ) and known X-ray crystal structures of human and rabbit TPI. The fish sequence was then aligned with the rabbit TPI and human TPI sequences. The fish TPI...”
P48501 Triosephosphate isomerase from Schistosoma mansoni
41% identity, 96% coverage
- Structural Analysis of an Epitope Candidate of Triosephosphate Isomerase in Opisthorchis viverrini
Son, Scientific reports 2018 - “...sinensis (accession code: G7YDG0) , Schistosoma haematobium (A5A6F9) , Schistosoma japonicum (Q27775) , Schistosoma mansoni (P48501) , Schistosoma turkestanicum (Q45XG1), and Taenia solium (Q9GTX8)) is represented as color variations in a surface model from cyan (lowest conserved residue) to wine (highest conserved residue). ( b )...”
- The secreted triose phosphate isomerase of Brugia malayi is required to sustain microfilaria production in vivo
Hewitson, PLoS pathogens 2014 - “...acid alignment of Bm -TPI (XP_001897269) with Ls -TPI (Hx2000032586), Ce -TPI (NP_496563), Sm -TPI (P48501), mouse TPI (NP_033441) and human TPI (NP_000356). B . Michaelis-Menten kinetics comparing activity of recombinant Bm - and Ls -TPI with native rabbit TPI. Results are representative of multiple batches...”
- Biology of the schistosome lung-stage schistosomulum
Gobert, Parasitology 2007 - “...Thioredoxin-related 32 kDa protein 2096 (LS) 0 Contig5222 S. japonicum thioredoxin 246 (MT) 117E-07 TPI P48501 14 Contig6423 S. japonicum triosephosphate isomerase 671 (MT) 194E-10 2D electrohporesis and protein sequencing data from Curwen et al. (2004) , using mechanically transformed S. mansoni schistosomula. Microarray data from...”
Smp_003990, XP_018647623 putative triosephosphate isomerase from Schistosoma mansoni
G4V6B9 Triosephosphate isomerase from Schistosoma mansoni
41% identity, 96% coverage
- Crystal structures of Triosephosphate Isomerases from Taenia solium and Schistosoma mansoni provide insights for vaccine rationale and drug design against helminth parasites
Jimenez-Sandoval, PLoS neglected tropical diseases 2020 - “...of TPI from T . solium (TsTPI) and S . mansoni (SmTPI) (GenBank: AAG21132.1 and XP_018647623 respectively) [ 44 , 45 ] were codon optimized and synthetically synthesized for their expression in E . coli ( S1 Table ). The synthetic genes were subcloned into the...”
- Composition of the Schistosoma mansoni worm secretome: Identification of immune modulatory Cyclophilin A
Floudas, PLoS neglected tropical diseases 2017 - “...S . mansoni adult male worm secretome. ID Protein description Vaccine name Vaccine type Reference Smp_003990 Triosephosphate isomerase, putative TPI Transfer of anti-TPI monoclonal antibody [ 33 ] Smp_017730 200-kDa GPI-anchored surface glycoprotein ECL (200 kDa protein) DNA [ 36 ] Smp_054160 Glutathione S-transferase 28 kDa...”
- Do schistosome vaccine trials in mice have an intrinsic flaw that generates spurious protection data?
Wilson, Parasites & vectors 2016 - “...protein AAI38692.1 4 22.6 0.55 Smp_085540 Myosin heavy chain 50 myosin-7 NP_542766.1 46 170.99 0.54 Smp_003990 TPI 64 TPI AAC36016.1 9 28.1 0.50 Dynein DLC13 45 dynein light chain NP_080832.1 2 9.3 0.48 Smp_097800 Y box 65 Y box transcription factor AAB94768.1 7 23.8 0.45 Smp_056970...”
- Protein and small non-coding RNA-enriched extracellular vesicles are released by the pathogenic blood fluke Schistosoma mansoni
Nowacki, Journal of extracellular vesicles 2015 - “...protein; Smp_040130, cyclophilin; Smp_056970.1, GAPDH; Smp_214190, calpain; Smp_042160.2, fructose bisphosphate aldolase; Smp_086480, SmTAL2; Smp_086530, SmTAL3; Smp_003990, triosephosphate isomerase 1a). While holocrine secretion, schistosomula damage or cultivation conditions could be responsible for the presence of these cytosolic proteins in E/S proteomes, our results now provide an alternative...”
- Serological screening of the Schistosoma mansoni adult worm proteome
Ludolf, PLoS neglected tropical diseases 2014 - “...Smp_056440 x Transketolase Smp_059790.2 x Trimeric G-protein alpha o subunit Smp_016630.2 x Triose phosphate isomerase Smp_003990 x x Troponin I ( S. japonicum ) 6 gil226481381 x Troponin T Smp_179810 x Tubulin alpha chain Smp_016780 x Total number of identified proteins: 47 22 29 18 25...”
- On the three-finger protein domain fold and CD59-like proteins in Schistosoma mansoni
Farias, PLoS neglected tropical diseases 2013 - “...Ct method was employed for relative quantification [42] with S. mansoni triose phosphate isomerase (SmTPI, Smp_003990) as the normalizing gene. We used the expression of SmCD59.6 from adult worm stage as calibrator to calculate the relative expression of all other SmCD59 analyzed, because this gene had...”
- Proteomic identification of IPSE/alpha-1 as a major hepatotoxin secreted by Schistosoma mansoni eggs
Abdulla, PLoS neglected tropical diseases 2011 - “...dehydrogenase Smp_035270.2 18 34 5.98 1.90E-10 36.2 10, 11, 1416, 20, 21 ++ triosephosphate isomerase Smp_003990 16 43 4.81 2.70E-08 28.1 1618 + purine nucleoside phosphorylase Smp_090520 15 31 4.76 3.30E-08 45.2 6, 14, 19 ++ family C56 non-peptidase homologue (C56 family) Smp_082030 10 69 6.02...”
- Proteomic analysis of Schistosoma mansoni proteins released during in vitro miracidium-to-sporocyst transformation
Wu, Molecular and biochemical parasitology 2009 - “...I Smp_042160.2 1407 16 5,6 0.317 Leishmanolysin-like protease Smp_167070 1180 10 3,4 0.308 Triosephosphate isomerase Smp_003990 1175 9 8,9 0.508 -N-acetylgalactosaminidase Sm06626 1171 10 4,5 0.540 22.6 kDa tegumental antigen Smp_086470 1171 8 10-15 0.452 Phosphopyruvate hydratase/enolase Smp_024110 863 9 4,5 0.471 ATP:guanidino kinase smc74 Smp_194770...”
- “...N CHO metabolism; glycolysis; gluconeogenesis Eukaryotic phosphomannomutase Smp_087860 N hexose metabolism; mannose biosynthesis Triosephosphate isomerase Smp_003990 N CHO metabolism; glycolytic activity Transketolase Smp_059790.2 N CHO metabolism; glycolysis; pentose-P shunt -N-acetylgalactosaminidase Sm06626 N carbohydrase activity; CHO binding Glycogen phosphorylase Smp_143840 N glucose phosphorylation; Glc-1-P synthesis Phosphoenolpyruvate carboxykinase...”
- Known Allergen Structures Predict Schistosoma mansoni IgE-Binding Antigens in Human Infection
Farnell, Frontiers in immunology 2015 - “...protease inhibitor) Serpin serine protease inhibitor G4LZN6 Sm Triosephosphate Isomerase PF00121 Triosephosphate Isomerase Triosephosphate isomerase G4V6B9 Sm Cyclophilin PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Cyclophilin Q26565 Sm HSP70 PF00012 Hsp70 protein Heat shock protein Hsp 70 G4V8L4 Sm GST26 PF00043 Glutathione S-transferase, C-terminal domain Glutathione S-transferase...”
Sb02g031030 No description from Sorghum bicolor
43% identity, 81% coverage
6ooiC / P48501 Crystal structure of triosephosphate isomerase from schistosoma mansoni in complex with 2pg (see paper)
41% identity, 95% coverage
- Ligand: 2-phosphoglycolic acid (6ooiC)
FFUJ_03280 probable TPI1-triose-phosphate isomerase from Fusarium fujikuroi IMI 58289
43% identity, 100% coverage
- Gene Cloning, Recombinant Expression, Characterization, and Molecular Modeling of the Glycolytic Enzyme Triosephosphate Isomerase from Fusarium oxysporum
Hernández-Ochoa, Microorganisms 2019 - “..., Figure S1: Nucleotide sequences of Tpis from different Fusarium species used for primers design. FFUJ_03280 ( Fusarium fujikuroi ), FOC1_g10013520 ( F . oxysporum f. sp. cubense race 1), FPRO_05057 ( Fusarium proliferatum ), FGRAMPH1_01G22955 ( Fusarium graminearum ), FOMG_04813 ( F . oxysporum f....”
- “...analysis of Tpi genes among Fusarium species; graphic representation of exonintron structures displayed using GSDS. FFUJ_03280 ( F . fujikuroi IMI 58289), FOMG_04813 ( F . oxysporum f. sp. melonis 26406), FGRAMPH1_01G22955 ( F . graminearum PH-1), FOXG_02233 ( F . oxysporum f. sp. lycopersici 4287),...”
P46226 Triosephosphate isomerase, cytosolic from Secale cereale
43% identity, 99% coverage
- Identification of Proteomic Components Associated with Resistance to Fusarium Head Blight in Rye
Perlikowski, The plant pathology journal 2019 - “...1-Cys peroxiredoxin PER1 [ Aegilops tauschii subsp. tauschii ] 376 22 6 redox homeostasis 11 P46226 triosephosphate isomerase [ Secale cereale ] 1071 52 11 carbohydrate metabolism 12 BAK03707 predicted protein [ Hordeum vulgare subsp. vulgare ] blastp: uncharacterized protein 318 42 4 - 13 -...”
- Characterization and Relative Quantitation of Wheat, Rye, and Barley Gluten Protein Types by Liquid Chromatography-Tandem Mass Spectrometry
Lexhaller, Frontiers in plant science 2019 - “...T T T T 13.52 10.00 8.31 2.03 18 5 4 1 Tri a 31 P46226 d Triosephosphate-isomerase 27 -75k-secalins -40k-secalins T T 2.00 9.85 1 5 Tri a 32 Q6W8Q2 1-cys-peroxiredoxin LMW-GS T 2.47 1 Tri a 33 Q9ST57 Serpin -40k-secalins C 2.02 1 Tri...”
- Effects of different nitrogen fertilizers on two wheat cultivars: An integrated approach
Vita, Plant direct 2018 - “...biosynthesis protein PDX1.1 221 15 33.6 33.7 6.70 6.4 318 4 4 0.64 20 55 P46226 Secale cereale Triosephosphate isomerase 924 62 27.3 26.8 5.88 5.24 253 37 15 7.43 56 I1HWV6 Brachypodium distachyon Uncharacterized protein 392 38 27.3 27.3 5.88 5.67 242 9 8 1.62...”
- Alterations in Kernel Proteome after Infection with Fusarium culmorum in Two Triticale Cultivars with Contrasting Resistance to Fusarium Head Blight
Perlikowski, Frontiers in plant science 2016 - “...disulfide isomerase 3 precursor [ T. aestivum ] 716 20 10 109 57/4.96 32/5.48 20 P46226 triosephosphate isomerase, cytosolic [ S. cereale ] 976 38 9 123 27/5.24 27/5.53 21 AAZ95171 eukaryotic translation initiation factor 5A1 [ T. aestivum ] 338 23 5 106 18/5.70 28/5.98...”
- Proteomic analysis of developing rye grain with contrasting resistance to preharvest sprouting
Masojć, Journal of applied genetics 2013 - “...factor Tu ( Delftia acidovorans SPH-1) Transport of t-RNA to ribosomes/molecular chaperone 181/8% 28 f P46226 Triosephosphate isomerase, cytosolic ; ( Secale cereale ) Glycolysis 111/9% Present only in RL P16062 Subtilisin-chymotrypsin inhibitor CI-1A ( Hordeum vulgare subsp. vulgare ) Defence 141/15% 29 BAJ86520 Predicted protein...”
- Proteomic analysis of preharvest sprouting in rye using two-dimensional electrophoresis and mass spectrometry
Masojć, Molecular breeding : new strategies in plant improvement 2012 - “...( Triticum aestivum ) Antioxidant and ROS-scavenger pathway 815 63 2.0 higher in SL 18 P46226 Triose phosphate isomerase, cytosolic ( Secale cereale ) Energy metabolism (glycolysis) 318 29 2.0 higher in SL 19 P15252 Rubber elongation factor protein ( Hevea brasiliensis ) Here ambiguous function...”
C5XQ07 Triosephosphate isomerase, cytosolic from Sorghum bicolor
43% identity, 82% coverage
- Identifying differentially expressed proteins in sorghum cell cultures exposed to osmotic stress
Ngara, Scientific reports 2018 - “...family 148 C5WT45 Uncharacterized protein OS= Sorghum bicolor GN=SORBI_001G168500 3.55 0.33 6.16E-06 Serpin family 152 C5XQ07 Uncharacterized protein OS= Sorghum bicolor GN=SORBI_003G072300 5.32 1.29 1.52E-04 Triosephosphate isomerase 165 A0A1B6PLT5 Uncharacterized protein OS= Sorghum bicolor GN=SORBI_006G133000 2.14 0.38 5.89E-04 + Galactose-binding domain-like 168 C5XG88 Small ubiquitin-related modifier...”
FTN_1631 triosephosphate isomerase from Francisella tularensis subsp. novicida U112
38% identity, 98% coverage
- Importance of Metabolic Adaptations in Francisella Pathogenesis
Ziveri, Frontiers in cellular and infection microbiology 2017 - “...FTN_0648 ); eno ( FTN_0621 ); glpX ( FTN_0298 ); pfk ( FTN_1210 ); ( FTN_1631 ); glpD ( FTN_1584 ); glpK ( FTN_1585 ). x ess , essential genes. * Expression of fba and pgK have shown to be up-regulated in BMM (Wehrly et al.,...”
XF0303 triosephosphate isomerase from Xylella fastidiosa 9a5c
38% identity, 98% coverage
- Xylella fastidiosa gene expression analysis by DNA microarrays
Travensolo, Genetics and molecular biology 2009 - “...-1.30 XF1144 atpG ATP synthase -1.29 XF0557 az 1 Electron transfer protein azurin I -1.28 XF0303 tpiA Triosephosphate isomerase -1.27 XF1746 yahK Alcohol dehydrogenase -1.24 XF0183 gcvT Glycine cleavage T protein -1.24 XF1211 mdh Malate dehydrogenase -0.97 XF0258 rfbC DTDP-4-keto-L-rhamnose reductase -0.87 XF1550 odhA Oxoglutarate dehydrogenase...”
XP_001274623 triosephosphate isomerase from Aspergillus clavatus NRRL 1
42% identity, 95% coverage
- Histoplasma capsulatum proteome response to decreased iron availability
Winters, Proteome science 2008 - “...NAm1]. 10/21 38% XP_001538605 142 Spot 35* triosephosphate isomerase [Aspergillus clavatus NRRL 1]. 7/19 33% XP_001274623 103 Spot 36 30 kDa heat shock protein [Ajellomyces capsulatus NAm1]. 10/28 31% XP_001540271 125 Spot 37 superoxide dismutase, mitochondrial precursor [Ajellomyces capsulatus NAm1]. 5/16 21% XP_001541351 78 Spot 38...”
Q9FS79 Triosephosphate isomerase, cytosolic from Triticum aestivum
43% identity, 99% coverage
- Spirulina (Arthrospira platensis): Antiallergic Agent or Hidden Allergen? A Literature Review
Gromek, Foods (Basel, Switzerland) 2024 - “...(L7UZA7 and A0A088SAX2) are associated with Dermatophagoides farinae [ 58 , 59 ], and protein Q9FS79 is associated with Triticum aestivum . These proteins are not considered to be food allergens but are inhalant allergens [ 4 ]. The rest of the identified triosephosphate isomerases are...”
- Characterization and Relative Quantitation of Wheat, Rye, and Barley Gluten Protein Types by Liquid Chromatography-Tandem Mass Spectrometry
Lexhaller, Frontiers in plant science 2019 - “...amount of total, unique peptide evidence related to a given protein, d 96% identity to Q9FS79 Triticum aestivum. Beside the shown exemplary allergens, many identified proteins contained peptides with known CD-active sequences. Immunoreactive peptides carrying known, non-deamidated peptide-binding motifs of gluten-specific T-cells are shown in Table...”
An14g04920 triose-phosphate-isomerase tpiA from patent WO8704464-A-Aspergillus niger from Aspergillus niger
40% identity, 95% coverage
- Cytosolic streaming in vegetative mycelium and aerial structures of Aspergillus niger
Bleichrodt, Studies in mycology 2013 - “...encoded by An07g00070 - Aspergillus niger An08g01960 1168 Strong similarity to adenosylhomocysteinase - Homo sapiens An14g04920 1167 Triose-phosphate-isomerase tpiA from patent WO8704464-A - Aspergillus niger An11g01630 1167 Strong similarity to thiazole biosynthesis protein nmt2p - Schizosaccharomyces pombe An17g01360 1157 Strong similarity to cytoplasmic ribosomal protein of...”
- “...Fba1 - Saccharomyces cerevisiae An04g06510 1466 Strong similarity to polyubiquitin 5 Ubi4 - Saccharomyces cerevisiae An14g04920 1349 Triose-phosphate-isomerase tpiA from patent WO8704464-A - Aspergillus niger An12g07450 1332 Strong similarity to glucose permease Rgt2 - Saccharomyces cerevisiae An18g05640 1322 Strong similarity to hypothetical mold-specific protein MS8 -...”
- Trancriptional landscape of Aspergillus niger at breaking of conidial dormancy revealed by RNA-sequencing
Novodvorska, BMC genomics 2013 - “...5.64 An04g04890 glycerol kinase 24.53 209.95 50.67 4.14 An08g00210 glycerol-3-phosphate dehydrogenase 16.76 80.42 25.23 3.18 An14g04920 tpiA , triose-phosphate-isomerase 29.26 72.81 4.87 14.95 An16g01830 gpdA , glyceraldehyde-3 phosphate dehydrogenase 14.75 107.99 19.98 5.40 An07g05790 osmoregulator ( S. cerevisiae SGD1 ) 11.18 3.14 96.62 30.7 Nitrogen metabolism...”
- “...by triose-phosphate-isomerase. Transcript levels of genes encoding glycerol kinase (An04g04890), glycerol-3-phosphate dehydrogenase (An08g00210), triose-phosphate-isomerase tpiA (An14g04920) and glyceraldehyde-3 phosphate dehydrogenase gpdA (An16g01830) showed high abundance in dormant conidia and the levels decreased at the breaking of dormancy and did not show up-regulation at later stages of...”
- The intra- and extracellular proteome of Aspergillus niger growing on defined medium with xylose or maltose as carbon substrate
Lu, Microbial cell factories 2010 - “...background) include enzymes from the glycolytic pathway: 4 (fructose-bis-phosphate aldolase, An02g07470); 5 (triose phosphate isomerase, An14g04920); 6 (glyceraldehde-3-phosphate dehydrogenase, An16g01830); 7 (phosphoglycerate kinase, An08g02260); 9 (enolase, An18g06250); 11 (pyruvate dehydrogenase complex: pyruvate dehydrogenase E1, An07g09530, dihydrolipoamide dehydrogenase E3, An07g06840); TCA cycle enzymes: 13 (aconitase, An08g10530); 15...”
FPRO_05057 putative TPI1-triose-phosphate isomerase from Fusarium proliferatum ET1
43% identity, 100% coverage
- Gene Cloning, Recombinant Expression, Characterization, and Molecular Modeling of the Glycolytic Enzyme Triosephosphate Isomerase from Fusarium oxysporum
Hernández-Ochoa, Microorganisms 2019 - “...FFUJ_03280 ( Fusarium fujikuroi ), FOC1_g10013520 ( F . oxysporum f. sp. cubense race 1), FPRO_05057 ( Fusarium proliferatum ), FGRAMPH1_01G22955 ( Fusarium graminearum ), FOMG_04813 ( F . oxysporum f. sp. melonis), FOZG_04985 ( Fusarium oxysporum ), FOXG_02233 ( F . oxysporum f. sp. lycopersici),...”
- “...oxysporum f. sp. lycopersici 4287), FOC1_g10013520 ( F . oxysporum f. sp. cubense race 1), FPRO_05057 ( F . proliferatum ET1), FOZG_04985 ( F. oxysporum Fo47 ); ( C ) vector constructed for the expression of the recombinant FoxTPI protein, named pET3a-HisTEV-FoxTPI, carrying the FoxTpi gene...”
B4F820 Triosephosphate isomerase, chloroplastic from Zea mays
42% identity, 81% coverage
5zfxB / A0A074Z863 Crystal structure of triosephosphate isomerase from opisthorchis viverrini (see paper)
40% identity, 98% coverage
- Ligand: magnesium ion (5zfxB)
GRMZM5G852968 uncharacterized protein LOC100191222 from Zea mays
42% identity, 81% coverage
B6UG30 Triosephosphate isomerase from Zea mays
42% identity, 81% coverage
APL_1925 Triosephosphate isomerase from Actinobacillus pleuropneumoniae L20
42% identity, 98% coverage
U876_04895 triose-phosphate isomerase from Aeromonas hydrophila NJ-35
38% identity, 99% coverage
- Discovery of lahS as a Global Regulator of Environmental Adaptation and Virulence in Aeromonas hydrophila
Dong, International journal of molecular sciences 2018 - “...protein 28.34991961 U876_01465 Catalase 11.31448355 U876_16540 Peroxidase 2.09906885 U876_04415 Cytochrome C biogenesis protein CcsA 2.043010753 U876_04895 Triose-phosphate isomerase 2.939215876 U876_07195 Fructose-6-phosphate aldolase 2.67060636 U876_05460 Penicillin-sensitive transpeptidase 6.074663579 U876_13305 Transcriptional regulator 2.236916529 U876_10585 Prolyl-tRNA synthetase 2.143335753 U876_23535 Chromosome partitioning protein ParA 2.1254663 Down-regulated proteins U876_07270 Flagellar hook...”
D2D303 Triosephosphate isomerase, cytosolic from Gossypium hirsutum
41% identity, 99% coverage
BAB1_1161 Triosephosphate isomerase from Brucella melitensis biovar Abortus 2308
40% identity, 97% coverage
CNAG_02035 triose-phosphate isomerase from Cryptococcus neoformans var. grubii H99
40% identity, 100% coverage
- A Fungal Arrestin Protein Contributes to Cell Cycle Progression and Pathogenesis
Telzrow, mBio 2019 - “...Ubiquitin-activating enzyme E1 4.0 0.0 CNAG_06666 -1,4-Glucan phosphorylase 3.7 0.0 CNAG_02565 Homoaconitase, mitochondrial 3.7 0.0 CNAG_02035 Triosephosphate isomerase 3.7 0.0 CNAG_05650 UBP5 Ubiquitin carboxyl-terminal hydrolase 7 3.7 0.0 CNAG_00708 Pre-mRNA-splicing factor Slt11 3.3 0.0 CNAG_01981 Sulfide:quinone oxidoreductase 3.3 0.0 CNAG_03249 THO complex, subunit 4 3.3 0.0...”
- Cryptococcus neoformans can form titan-like cells in vitro in response to multiple signals
Trevijano-Contador, PLoS pathogens 2018 - “...CNAG_05480, encoding two isoforms of hexokinase, CNAG_03916 (glucose-6-phosphate isomerase), CNAG_04676 (6-phosphofructokinase), CNAG_06770 (fructose-bisphosphate aldolase 1), CNAG_02035 (triose-phosphate isomerase) and two isoforms of enolase (CNAG_03072 and CNAG_06868). The TCA cycle was also affected, with induction of mitochondrial citrate synthase (CNAG_00061), E1 and E2 components of ketoglutarate deshydrogenase...”
- “...2.7 1.5E-04 CNAG_04676 6-phosphofructokinase 1.2 6.0E-03 2.1 2.6E-02 CNAG_06770 fructose-bisphosphate aldolase 1 0.8 2.0 2.3E-02 CNAG_02035 triose-phosphate isomerase 0.8 2.3E-02 2.1 1.4E-02 CNAG_03072 enolase ( ENO1 ) 1.3 2.6E-04 2.2 6.5E-03 CNAG_06868 phosphopyruvate hydratase ( ENO2 ) 0.4 3.2 3.3E-02 TCA cycle (p-value : 3 ....”
- Characterization of Lipids and Proteins Associated to the Cell Wall of the Acapsular Mutant Cryptococcus neoformans Cap 67
Longo, The Journal of eukaryotic microbiology 2015 - “...shock 70 kDa protein 4 (CNAG_06208) ( Bisio et al. 2005 ), triose-phosphate isomerase (TPI) (CNAG_02035), and glyceraldehyde-3-phosphate dehydrogenase (GAPDH)(CNAG_06699) ( da Fonseca et al. 2001 ). Vaccination using Hsp60 induced protective cellular immune response against experimental pulmonary PCM ( de Bastos Ascenco Soares et al....”
- “...CNAG_01820 pyruvatekinase Ca Sc CnHcSc CNAG_01896 alcoholdehydrogenase Ca Pb CnPbSc CNAG_01984 transaldolase Ca Sc CnHcPbSc CNAG_02035 triose-phosphateisomerase Ca Sc HcPbSc CNAG_02818 glycine cleavage system T protein - CnHc CNAG_03072 enolase Af Ca PbSc CnPbSc CNAG_03225 malatedehydrogenase, NAD-dependent Ca CnHcPbSc CNAG_03358 phosphoglyceratekinase Af Ca Sc CnHcPbSc CNAG_03525...”
B9GJN0 Uncharacterized protein from Populus trichocarpa
42% identity, 98% coverage
- Proteomic analysis reveals a role of melatonin in promoting cucumber seed germination under high salinity by regulating energy production.
Zhang, Scientific reports 2017 - “...chloroplastic A0A072U2W1 6.60 0.00174 Triosephosphate isomerase cytosolic A0A067LKT3 7.05 0.00842 14.10 0.15009 Triosephosphate isomerase cytosolic B9GJN0 8.23 0.00026 11.29 0.00307 Triosephosphate isomerase cytosolic Q38IW8 10.64 0.00037 11.03 0.00048 Glucan endo- -beta-glucosidase 4 W9RG25 0.19 0.00031 0.29 0.04885 Lysosomal alpha-mannosidase isoform x1 A0A075CA98 4.21 0.00017 4.33 0.00378...”
- “...chloroplastic A0A072U2W1 6.60 0.00174 Triosephosphate isomerase cytosolic A0A067LKT3 7.05 0.00842 14.10 0.15009 Triosephosphate isomerase cytosolic B9GJN0 8.23 0.00026 11.29 0.00307 Triosephosphate isomerase cytosolic Q38IW8 10.64 0.00037 11.03 0.00048 indicates increased proteins, and indicates significant decreased protein (fold change2 or2 and P value<0.05). indicates not detected. Melatonin...”
TPIS_PARBA / Q96VN5 Triosephosphate isomerase; TIM; Triose-phosphate isomerase; EC 5.3.1.1 from Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides brasiliensis) (see paper)
43% identity, 95% coverage
- catalytic activity: D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate (RHEA:18585)
subunit: Homodimer. - Physical Features of Intracellular Proteins that Moonlight on the Cell Surface
Amblee, PloS one 2015 - “...(TEF1) plasminogen binding Candida albicans C4YDJ3 [ 26 ] Triose phosphate isomerase adhesin Paracoccidioides brasiliensis Q96VN5 [ 98 ] Triose phosphate isomerase adhesin Staphylococcus aureus D9RMW0 [ 99 ] Triose phosphate isomerase plasminogen binding Streptococcus anginosus and S . oralis E6J203 [ 50 ] Thiol-specific antioxidant...”
LOC110739768 triosephosphate isomerase, chloroplastic from Chenopodium quinoa
42% identity, 76% coverage
TPIS_CHICK / P00940 Triosephosphate isomerase; TIM; Methylglyoxal synthase; Triose-phosphate isomerase; EC 5.3.1.1; EC 4.2.3.3 from Gallus gallus (Chicken) (see paper)
P00940 triose-phosphate isomerase (EC 5.3.1.1) from Gallus gallus (see 3 papers)
NP_990782 triosephosphate isomerase from Gallus gallus
43% identity, 98% coverage
- function: Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis.
function: It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids.
catalytic activity: dihydroxyacetone phosphate = methylglyoxal + phosphate (RHEA:17937)
catalytic activity: D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate (RHEA:18585)
subunit: Homodimer. - Dimerization affects collective dynamics of triosephosphate isomerase.
Cansu, Biochemistry 2008 (PubMed)- GeneRIF: 1st essential mode contributing to 34% of overall motion of dimer is strongly coupled to loop 6's closure over active site. Onset of collective motions at ns time scale due to dimerization has functional implications as to coordination of loop 6 closure.
- Dynamic requirements for a functional protein hinge.
Kempf, Journal of molecular biology 2007 - GeneRIF: NMR study of wild-type (WT) TIM and a quintuple mutant (PGG/GGG).
- Value of a hydrogen bond in triosephosphate isomerase loop motion.
Berlow, Biochemistry 2007 (PubMed)- GeneRIF: There is clear evidence for motion with an exchange rate constant consistent with opening and closing of triosephosphate isomerase active site loop (loop 6) being partially rate-limiting to catalytic throughput.
- Entropy effects on protein hinges: the reaction catalyzed by triosephosphate isomerase.
Xiang, Biochemistry 2004 (PubMed)- GeneRIF: The hypothesis that limited access to conformational space is a requirement for protein hinges involved in catalysis has been successfully tested with glycine N- and C-terminal hinge mutants of loop 6 of triosephosphate isomerase (TIM).
- Ribosome External Electric Field Regulates Metabolic Enzyme Activity: The RAMBO Effect
Yu, The journal of physical chemistry. B 2024 - “...which confers ampicillin resistance and expresses 26.6 kDa 248 residue TPI from G. gallus (uniprot P00940 ), was purchased from Genscript and transformed into Escherichia coli strain BL21 (DE3) for overexpression. Ten milliliters of Luria broth, LB, medium containing 150 g/mL of carbenicillin was inoculated with...”
- “...related to Figure 8 ( PDF ) Supplementary Material jp4c00628_si_001.pdf Accession Codes TPI, UniProt entry P00940 , PDB entries 8TIM and 1TPH , and BMRB entries 15064 and 15065; 70S ribosome with EF-Tu and aminoacyl-tRNA in the preaccommodation state, PDB entry 5UYK . 70S Ribosome with...”
- Metalloproteomic analysis of liver proteins isolated from broilers fed with different sources and levels of copper and manganese
Aparecida, Scientific reports 2024 - “...P19121 ALB Albumin 5.51/69,918.19 93.6207 Q5ZLR5 UQCRFS1 Cytochrome b-c1 complex subunit Rieske, mitochondrial 8.68/29,386.56 92.6274 P00940 TPI1 Triosephosphate isomerase 6.71/26,620.45 91.4796 27 P07341 ALDOB Fructose-bisphosphate aldolase B 8.59/39,065 8.81/39,295.78 98.4781 High Cu/Mn (OH)Cl=Cu 28 P07341 ALDOB Fructose-bisphosphate aldolase B 8.6/35,327 8.81/39,295.78 17,119.69 High Cu/Mn SO 4...”
- “...P07341 ALDOB Fructose-bisphosphate aldolase B 8.81/39,295.78 522.2266 P00337 LDHB L-lactate dehydrogenase B chain 7.07/36,318.09 326.4798 P00940 TPI1 Triosephosphate isomerase 6.71/26,620.45 250.532 31 P51913 ENO1 Alpha-enolase 4.25/76,181 6.17/47,305.01 642.0277 High Cu/Mn (OH)Cl=Mn P07322 ENO3 Beta-enolase 7.28/47,196.08 545.8586 O57391 ENO2 Gamma-enolase 4.84/47,308.46 91.4921 32 P60706 ACTB Actin, cytoplasmic...”
- Comparative proteomics revealed duodenal metabolic function associated with feed efficiency in slow-growing chicken
Kaewsatuan, Poultry science 2022 - “...0.56 A0A3Q2UD12 Collagen alpha-3(VI) chain COL6A3 0.007 0.86 Q5ZLN1 Phosphoglycerate mutase 1 PGAM1 0.030 0.38 P00940 Triosephosphate isomerase 1 TPI1 0.045 0.55 A0A1D5P9N7 L-lactate dehydrogenase B chain LDHB 0.043 0.62 P84175 40S ribosomal protein S12 RPS12 0.017 0.51 F1NYE5 HABP4_PAI-RBP1 domain-containing protein RCJMB04_14f6 0.011 1.92 R4GM10...”
- Proteolysis and changes in meat quality of chicken pectoralis major and iliotibialis muscles in relation to muscle fiber type distribution
Cheng, Poultry science 2022 - “...nd nd 1 1 F1N9H4 Elongation factor 1-alpha Biosynthetic process 183 5 25 6 33 P00940 Triosephosphate isomerase Cytosol, glycolysis / gluconeogenesis, metabolic pathways, biosynthetic process 46 29 19 4 7 A0A1D5P810 ATP synthase subunit O, mitochondrial Metabolic pathways, biosynthetic process 8 nd nd 1 1...”
- Proteomic analysis of the liver regulating lipid metabolism in Chaohu ducks using two-dimensional electrophoresis.
Ge, Open life sciences 2022 - “...3.063502942 98.99 5.00 10 145 Peroxiredoxin-1 HSPA9 Q5ZM98 1.555816155 98.69 0 Stress-70 protein mitochondrial TPI1 P00940 1.469885976 99.6 0 Triosephosphate isomerase ENO1 P51913 1.189033824 97.24 0 Alpha-enolase GAPDH P00356 1.163498732 99.1 0 Glyceraldehyde-3-phosphate dehydrogenase ALDOB P07341 0.831877241 94.15 7.00 10 117 Fructose-bisphosphate aldolase B GPX1 R4GH86...”
- “...1.555816155 98.69 0 Q5ZM98 HSPA9 A0A1L1RLH6 1.531069493 100 0 Q9I9D1 VDAC2 A0A226MZ03 1.469885976 99.6 0 P00940 TPI1 A0A226PNR7 1.459431619 75 0 O93344 ALDH1A2 R0LLL3 1.207892852 94.22 0 E1BRE5 EEA1 F1NBJ7 1.207892852 100 0 F1NBJ7 SARDH P19140 1.189033824 97.24 0 P51913 ENO1 A0A346M329 1.163498732 99.1 0 P00356...”
- A Proteomic View of the Cross-Talk Between Early Intestinal Microbiota and Poultry Immune System
Rodrigues, Frontiers in physiology 2020 - “...Q5ZI89 TRAPPC11 Trafficking protein particle complex 11 1.000 0.007 Q01841 TGM2 Transglutaminase 2 1.420 0.010 P00940 TPI1 Triosephosphate isomerase 1 1.500 0.015 Q10751 ACE Angiotensin I converting enzyme 10.000 0.016 P55080 MFAP1 Microfibril-associated protein 1 7.500 0.018 Q5ZIV5 PDCD10 Programmed cell death protein 10 5.800 0.021...”
- Tandem mass tag-based quantitative proteomics analysis and gelling properties in egg albumen of laying hens feeding tea polyphenols.
Ding, Poultry science 2020 - “...CHTOP 0.63 0.02 Metabolic process Q5ZME2 Malate dehydrogenase, cytoplasmic Carbohydrate metabolic process MDH1 2.30 0.01 P00940 Triosephosphate isomerase Gluconeogenesis TPI1 2.16 0.02 P00340 L-lactate dehydrogenase A chain Carbohydrate metabolic process LDHA 1.71 0.03 O57579 Aminopeptidase Ey Peptide and metal binding ANPEP 1.26 0.03 A0A1D5PZE3 Apolipoprotein A-I...”
- “...metabolism 2 P00340, Q5ZME2 0.01 gga00480 Glutathione metabolism 2 P20136, O57579 0.02 gga00010 Glycolysis/gluconeogenesis 2 P00940, P00340 0.04 gga04141 Protein processing in endoplasmic reticulum 3 Q7SX63, P08110, Q8JG64 0.04 1 Each mean represents 3 replicates, with 2 eggs/replicate. 2 P values are calculated according to a...”
- Analysis of differentially expressed proteins in Muscovy duck embryo fibroblasts infected with virulent and attenuated Muscovy duck reovirus by two-dimensional polyacrylamide gel electrophoresis.
Huang, The Journal of veterinary medical science 2017 - “...2.83 7.16 0.042 6.50E-08 Q90593 78 kDa glucose-regulated protein 73.2 29 0.29 1.41 9.10E-12 0.27 P00940 Triosephosphate isomerase 62.8 13 1.03 1.19 0.93 0.59 Q90635 Dihydropyrimidinase-related protein 2 49.3 8 0.38 8.16 1.09E-05 7.64E-09 P09117 Fructose-bisphosphate aldolase C 33.9 5 0.28 5.49 2.23E-13 4.35E-07 Q2NL22 Eukaryotic...”
A0A074Z863 Triosephosphate isomerase from Opisthorchis viverrini
40% identity, 98% coverage
PAAG_02585, XP_002795879 triosephosphate isomerase from Paracoccidioides lutzii Pb01
43% identity, 93% coverage
- Immunoproteomic Analysis Reveals Novel Candidate Antigens for the Diagnosis of Paracoccidioidomycosis Due to Paracoccidioides lutzii
Rodrigues, Journal of fungi (Basel, Switzerland) 2020 - “...c ) heat shock protein 60, mitochondrial (XP_002789992 and XP_010763632), ( d ) triosephosphate isomerase (XP_002795879 and XP_010762134), ( e ) uncharacterized proteinThioredoxin-like superfamily (XP_015700719 and XP_010758121), and ( f ) uncharacterized proteinPRTases type I superfamily (XP_015701261 and XP_010756299). The antigenic propensity scores are plotted against...”
- “...6.21 16 228 Pl02 XP_015700719 PADG_02764 Uncharacterized protein (Thioredoxin-like Superfamily) 30,945 8.45 14 124 Pl05 XP_002795879 PADG_06906 Triosephosphate isomerase 27,159 5.39 24 408 Pl06 XP_002797384 PADG_03581 Phenylacetone monooxygenase 68,182 5.95 1 33 Pl07 XP_015701261 PADG_00322 Uncharacterized protein (PRTases type I Superfamily) 23,117 5.28 22 186 Pl08...”
- Interaction of Isocitrate Lyase with Proteins Involved in the Energetic Metabolism in Paracoccidioides lutzii
Freitas, Journal of fungi (Basel, Switzerland) 2020 - “...forms. Accession Protein Name Score ** Mycelium Glycolysis and Gluconeogenesis 60,211.38 PAAG_01995 fructose-bisphosphate aldolase 11,197.06 PAAG_02585 triosephosphate isomerase * 29,783.99 PAAG_02869 phosphoglycerate kinase 37,493.65 PAAG_06380 pyruvate kinase 24,097.65 PAAG_08203 phosphoenolpyruvate carboxykinase 10,288.74 Tricarboxylic-acid pathway 18,022.91 PAAG_01534 pyruvate dehydrogenase E1 component subunit beta 54,603.02 PAAG_03330 dihydrolipoyl dehydrogenase...”
- “...PAAG_04166 transaldolase 37,493.65 PAAG_04444 transketolase 24,097.65 Mycelium-to-yeast transition Glycolysis and Gluconeogenesis PAAG_01995 fructose-bisphosphate aldolase 14,297.79 PAAG_02585 triosephosphate isomerase * 12,564.27 PAAG_02869 phosphoglycerate kinase 12,361.49 PAAG_06380 pyruvate kinase 8237.422 PAAG_00726 pyruvate carboxylase 5375.759 PAAG_08203 phosphoenolpyruvate carboxykinase 4991.925 Tricarboxylic-acid pathway PAAG_01534 pyruvate dehydrogenase E1 component subunit beta 3429.868...”
- Proteomic profile response of Paracoccidioides lutzii to the antifungal argentilactone
Prado, Frontiers in microbiology 2015 - “...* Hydroxymethylglutaryl-CoA lyase PAAG_06215 1087.40 * Formate dehydrogenase-III PAAG_03599 1012.38 * Carbohydrate metabolism Triosephosphate isomerase PAAG_02585 10825.00 1.246 Pyruvate dehydrogenase complex component Pdx1 PAAG_00666 997.13 1.768 Pyruvate dehydrogenase complex PAAG_00050 877.32 1.616 Fumarate reductase Osm1 PAAG_04851 2013.07 1.234 4-hydroxyphenylpyruvate dioxygenase PAAG_07875 4971.33 1.568 N-acetylglucosamine-phosphate mutase PAAG_01931...”
Ot09g00080 Triosephosphate isomerase from Ostreococcus tauri
41% identity, 84% coverage
- Microarray data can predict diurnal changes of starch content in the picoalga Ostreococcus
Sorokina, BMC systems biology 2011 - “...x Ot03g00610 fbaII x Ot10g01490 3.1.3.11 Fructose-1,6-bisphosphatase x Ot03g00330 x Ot14g01140 5.3.1.1 Triosephosphate isomerase x Ot09g00080 5.3.1.9 Glucose-6-phosphate isomerase x Ot11g02980 5.4.2.2 phosphoglucomutase x Ot15g02630 2.7.7.27 ADP-glucose pyrophosphorylase AGPLU1 Ot07g03280 agpsu1 x Ot07g02930 agplu2 Ot20g00490 2.4.1.21 Soluble Starch synthase SSIII-C Ot06g03410 SSIII-B x Ot13g01250 SSII x...”
4bi7A / P36186 Crystal structure of a mutant (c202a) of triosephosphate isomerase from giardia lamblia complexed with 2-phosphoglycolic acid (see paper)
43% identity, 97% coverage
- Ligand: 2-phosphoglycolic acid (4bi7A)
E5SS61 Triosephosphate isomerase from Trichinella spiralis
42% identity, 90% coverage
- Quantitative label-free proteomic analysis of excretory-secretory proteins in different developmental stages of Trichinella spiralis
Liu, Veterinary research 2024 - “...map of glycolysis/gluconeogenesis revealed that several related proteins, phosphoglucomutase (E5SQZ6), fructose-bisphosphate aldolase (A0A0V1AX39), triosephosphate isomerase (E5SS61), phosphoglycerate kinase (A0A0V1B8E2), enolase (A0A0V1BT87), and phosphoenolpyruvate carboxykinase (A0A0V1AZ55), were significantly upregulated in IIL-ES compared with ML-ES ( P <0.05) (Figure 9 A). However, the proteins A0A0V1AX39, A0A0V1B8E2, A0A0V1BT87, and...”
- “...<0.05) (Figure 9 B). For Ad 6 dpi-ES, the expression of the proteins E5SQZ6, A0A0V1AX39, E5SS61, A0A0V1BT87, and A0A0V1AZ55 was also significantly downregulated ( P <0.05) (Figure 9 C). However, the glycolysis/gluconeogenesis pathway was not significantly different between PA 30h-ES and Ad 3 dpi-ES. A pathway...”
PITG_13116 triosephosphate isomerase from Phytophthora infestans T30-4
40% identity, 99% coverage
NCU07550 triosephosphate isomerase from Neurospora crassa OR74A
43% identity, 98% coverage
LOC108986375 triosephosphate isomerase, cytosolic from Juglans regia
41% identity, 99% coverage
- Integrated Transcriptomic and Proteomic Analysis of Nutritional Quality-Related Molecular Mechanisms in "Longjia", "Yangpao", and "Niangqing" Walnuts (<i>Juglans sigillata</i>)
Wang, International journal of molecular sciences 2024 - “...KEGG signaling pathway (protein processing in endoplasmic reticulum). High correlations were observed between XP_018811458.1 and LOC108986375, LOC109020832, and LOC109021727, as well as between XP_018818540.2 and LOC109005833, LOC108986375, and LOC109006316. XP_018805731.1 exhibited high correlations with all DEGs analyzed ( Figure 6 D). Through interaction analysis, key nodes...”
- “...walnut fatty acid biosynthesis were identified, including XP_018805731.1, XP_018811458.1, XP_018818540.2, LOC109021470, LOC109011248, LOC109020832, LOC109010118, LOC109002332, LOC108986375, and LOC108989469 ( Figure 6 E,F). These findings reveal crucial proteins and genes involved in walnut fatty acid biosynthesis, protein synthesis, and processing, highlighting their essential roles in walnut growth,...”
PADG_06906, XP_010762134 triosephosphate isomerase from Paracoccidioides brasiliensis Pb18
42% identity, 86% coverage
- Immunoproteomic Analysis Reveals Novel Candidate Antigens for the Diagnosis of Paracoccidioidomycosis Due to Paracoccidioides lutzii
Rodrigues, Journal of fungi (Basel, Switzerland) 2020 - “...16 228 Pl02 XP_015700719 PADG_02764 Uncharacterized protein (Thioredoxin-like Superfamily) 30,945 8.45 14 124 Pl05 XP_002795879 PADG_06906 Triosephosphate isomerase 27,159 5.39 24 408 Pl06 XP_002797384 PADG_03581 Phenylacetone monooxygenase 68,182 5.95 1 33 Pl07 XP_015701261 PADG_00322 Uncharacterized protein (PRTases type I Superfamily) 23,117 5.28 22 186 Pl08 XP_002797532...”
- “...5.28 17 175 Pb45 XP_010763035 PADG_07782 Deoxyuridine 5-triphosphate nucleotidohydrolase 22,190 5.27 12 75 Pb46 XP_010762134 PADG_06906 Triosephosphate isomerase 27,176 5.39 10 66 Pb48 XP_010759909 PADG_11679 Proliferating cell nuclear antigen 36,276 4.87 11 205 Pb49 XP_010759842 PADG_04440 Uncharacterized protein (14-3-3 Superfamily) 29,738 4.68 24 322 Pb50 XP_010759301...”
- “...heat shock protein 60, mitochondrial (XP_002789992 and XP_010763632), ( d ) triosephosphate isomerase (XP_002795879 and XP_010762134), ( e ) uncharacterized proteinThioredoxin-like superfamily (XP_015700719 and XP_010758121), and ( f ) uncharacterized proteinPRTases type I superfamily (XP_015701261 and XP_010756299). The antigenic propensity scores are plotted against position along...”
- “...24,931 5.28 17 175 Pb45 XP_010763035 PADG_07782 Deoxyuridine 5-triphosphate nucleotidohydrolase 22,190 5.27 12 75 Pb46 XP_010762134 PADG_06906 Triosephosphate isomerase 27,176 5.39 10 66 Pb48 XP_010759909 PADG_11679 Proliferating cell nuclear antigen 36,276 4.87 11 205 Pb49 XP_010759842 PADG_04440 Uncharacterized protein (14-3-3 Superfamily) 29,738 4.68 24 322 Pb50...”
- Metabolic Peculiarities of Paracoccidioides brasiliensis Dimorphism as Demonstrated by iTRAQ Labeling Proteomics
Araújo, Frontiers in microbiology 2019 - “...phase and yeast cells. For example, fructose-1,6-bisphosphate aldolase, class 2 (PADG_00852), hexokinase (PADG_07950), triosephosphate isomerase (PADG_06906), and 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (PADG_05109) were up-regulated in mycelium. In respect to enzymes related to alcoholic fermentation, alcohol dehydrogenase ADH1 (PADG_11405) was induced in comparison to the other two developmental...”
- Vesicle and vesicle-free extracellular proteome of Paracoccidioides brasiliensis: comparative analysis with other pathogenic fungi
Vallejo, Journal of proteome research 2012 - “...glyceraldehyde-3-phosphate dehydrogenase (PADG_02411), 47 enolase (PADG_04059), 48 gp43 (PADG_07615), 49 , 50 and triosephosphate isomerase (PADG_06906). 51 Gp43 is the best studied molecule in P. brasiliensis for its antigenic, immunomodulatory and protective properties. Although the molecule is in the group of beta-1,3-exoglucanases, it is not enzymatically...”
- “...CNAG_00965 YBR117C* 9 NS PADG_00668 fructose-bisphosphate aldolase (361 aa) Yes NF* HCAG_00010 YKL060C 10 - PADG_06906 triosephosphate isomerase (250 aa) Yes Yes HCAG_02511 YDR050C 11 NS PADG_02411 glyceraldehyde-3-phosphate dehydrogenase (339 aa) Yes Yes HCAG_04910 CNAG_06699 YGR192C* 12 - PADG_04059 enolase (439 aa) Yes Yes CNAG_03072 YGR254W*...”
P36186 triose-phosphate isomerase (EC 5.3.1.1) from Giardia intestinalis (see 3 papers)
GL50803_0093938, GL50803_93938, XP_001706830 Triosephosphate isomerase, cytosolic from Giardia intestinalis
43% identity, 97% coverage
- Comprehensive analysis of flavohemoprotein copy number variation in Giardia intestinalis: exploring links to metronidazole resistance
Korenková, Parasites & vectors 2024 - “...candidate reference genes were subsequently included in the analysis: NADP-specific glutamate dehydrogenase (GL50803_0021942), triosephosphate isomerase (GL50803_0093938) and nitroreductase Fd-NR2 (GL50803_0022677). Coverage ratios were computed as the mean coverage of the region of interest divided by the mean coverage of the entire genome of each Giardia isolate...”
- A core UPS molecular complement implicates unique endocytic compartments at the parasite-host interface in Giardia lamblia
Balmer, 2022 - Screening of the Pathogen Box for inhibitors with dual efficacy against Giardia lamblia and Cryptosporidium parvum
Hennessey, PLoS neglected tropical diseases 2018 - “...for homologous recombination to target a genomic intergenic region which is flanked with GL50803_17200 and GL50803_93938. After electroporation, puromycin was used to select for transfected cells. LB = left border, pGDH = Promoter of glutamate dehydrogenase (GL50803_21942), Puro Res = puromycin N-acetyltransferase, pTub = tubulin promoter,...”
- Characterization of the Giardia intestinalis secretome during interaction with human intestinal epithelial cells: The impact on host cells
Ma'ayeh, PLoS neglected tropical diseases 2017 - “...118,4 GL50581_2893 Aspartate aminotransferase, cytoplasmic 103,66 GL50803_17570 Elongation factor 2 117,26 GL50581_4057 Tenascin precursor 101,34 GL50803_93938 Triosephosphate isomerase, cytosolic 114,07 GL50581_413 Elongation factor 1-alpha 99,37 GL50803_17277 Phospholipase B 112,21 GL50581_4499 Hypothetical protein 96,87 GL50803_11599 Lysophosphatidic acid phosphatase 105,32 GL50581_881 Hypothetical protein 88,04 GL50803_93548 Phospholipase B 101,25...”
- Proteomics of secretory and endocytic organelles in Giardia lamblia
Wampfler, PloS one 2014 - “...untranslated region of cyst wall protein 1 (GL50803_5638); RS1/2: recombination sites 1 (GL50803_17200) and 2 (GL50803_93938); GDH 5/3 UTR: 5 and 3 untranslated regions of glutamate dehydrogenase (GL50803_21942); Puro Res.: puromycin N-acetyltransferase. (TIF) Click here for additional data file. Figure S5 Gl96994HA-expressing cells at 7h post...”
- Reconstruction of Sugar Metabolic Pathways of Giardia lamblia
Han, International journal of proteomics 2012 - “...Alcohol dehydrogenase 1.1.1.2 GL50803_7982 Aldose 1-epimerase 5.1.3.3 GL50803_90872 Phosphoglycerate kinase 2.7.2.3 GL50803_9115 Glucose-6-phosphate isomerase 5.3.1.9 GL50803_93938 Triosephosphate isomerase 5.3.1.1 Table 2 Bacteria-like Giardia enzymes in glycolysis pathway. EC Enzyme name Best candidate Bit score E value 2.7.1.2 Glucokinase GL50803_8826 393 2.00 10 110 2.7.1.11 Phosphofructokinase GL50803_14993...”
- Determining the molecular mechanism of inactivation by chemical modification of triosephosphate isomerase from the human parasite Giardia lamblia: a study for antiparasitic drug design.
Enríquez-Flores, Proteins 2011 (PubMed)- GeneRIF: This study found that the Cys222 derivatization is responsible for G. lamblia triosephosphate isomerase (GlTIM) inactivation.
- Glucosylceramide synthesis inhibition affects cell cycle progression, membrane trafficking, and stage differentiation in Giardia lamblia
Stefanić, Journal of lipid research 2010 - “...the G. lamblia triose phosphate isomerase locus (GL50803_93938), and integration occurs by homologous recombination under selective pressure with the antibiotic...”
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- Expanding the antiprotozoal activity and the mechanism of action of n-butyl and iso-butyl ester of quinoxaline-1,4-di-<i>N</i>-oxide derivatives against <i>Giardia lamblia</i>, <i>Trichomonas vaginalis</i>, and <i>Entamoeba histolytica.</i> An <i>in vitro</i> and <i>in silico</i> approach
González-González, Journal of enzyme inhibition and medicinal chemistry 2024 - “...TIM from G. lamblia, was obtained from the AlphaFold database from the Uniprot access code P36186, which is the unmutated model of PDB:2DP3; TIM from T. vaginalis , and TrxR from E. histolytica structures were obtained from the Protein Data Bank (PDB), access codes PDB:3QSP and...”
CTIMC / P48491 cytosolic triose-phosphate isomerase (EC 5.3.1.1) from Arabidopsis thaliana (see paper)
TPIS_ARATH / P48491 Triosephosphate isomerase, cytosolic; TIM; Triose-phosphate isomerase; EC 5.3.1.1 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
P48491 triose-phosphate isomerase (EC 5.3.1.1) from Arabidopsis thaliana (see 2 papers)
AT3G55440, NP_191104 triosephosphate isomerase from Arabidopsis thaliana
NP_191104 TPI (TRIOSEPHOSPHATE ISOMERASE); triose-phosphate isomerase from Arabidopsis thaliana
41% identity, 99% coverage
- catalytic activity: D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate (RHEA:18585)
subunit: Homodimer. - Three consecutive cytosolic glycolysis enzymes modulate autophagic flux
Lee, Plant physiology 2023 - “...data from this article can be found in the GenBank/EMBL data libraries under accession numbers: AT3G55440 (CyTPI), AT3G04120 (GAPC1), AT1G13440 (GAPC2), AT1G79550 (PGK3), and AT5G66930 (ATG101). The accession numbers of all genes used in this study are listed in Supplemental Table S2 . Supplementary Material kiad439_Supplementary_Data...”
- “...AT4G29130 PGK3 Gramene: AT1G79550 PGK3 Araport: AT1G79550 ATG101 Gramene: AT5G66930 ATG101 Araport: AT5G66930 CyTPI Gramene: AT3G55440 CyTPI Araport: AT3G55440 ATG6 Gramene: AT3G61710 ATG6 Araport: AT3G61710 References Avin-Wittenberg T , Bajdzienko K , Wittenberg G , Alseekh S , Tohge T , Bock R , Giavalisco P...”
- Making watercress (Nasturtium officinale) cropping sustainable: genomic insights into enhanced phosphorus use efficiency in an aquatic crop
Hibbert, Frontiers in plant science 2023 - “...P deficiency ( Cheng etal., 2011 ). Genes involved in carbohydrate metabolism, such as CTIMC (AT3G55440) and the phosphoglucan phosphatase SEX4 (AT3G52180), were upregulated in P conditions ( Ktting etal., 2009 ). Upregulation of VTC4 (AT3G02870) is notable as it encodes a bi-functional enzyme involved in...”
- “...dwarfed shoots. RNA-seq results also support the role of sugars in P starvation responses. CTIMC (AT3G55440), involved in gluconeogenesis, had a log fold-change of 0.45 ( p < 0.0001) in P shoots compared to P+ shoots in our study ( Dumont etal., 2016 ). An increase...”
- Stress-related expression of the chloroplast EGY3 pseudoprotease and its possible impact on chloroplasts' proteome composition
Adamiec, Frontiers in plant science 2022 - “...6.1 4.6 AT4G33010 GLDP1 SPP6702 D S 100/113.8 6.2/6.5 395 246 8 5 6.8 4.3 AT3G55440 triosephosphate isomerase SPP2101 D S 30/27.4 5,2/5.4 318 110 5 2 22 8.8 Selected spots were cut from two gels representing different egy3 mutant lines and subjected to a separate...”
- An expanded role for the transcription factor WRINKLED1 in the biosynthesis of triacylglycerols during seed development
Kuczynski, Frontiers in plant science 2022 - “...TKL 1 (transketolase 1, AT3G60750) (p) 215() 1.00.6 1.00 0.93 ** TPI (Triose phosphate isomerase, AT3G55440) (c)6 +57(+) 76.222.2 0.92 0.93 ** For all the listed genes, WRI1 binding curves were determined three times. For gene names listed in bold all of the following criteria apply:...”
- Microtubule Dynamics Plays a Vital Role in Plant Adaptation and Tolerance to Salt Stress
Chun, International journal of molecular sciences 2021 - “...pathways via the reestablishment of ROS homeostasis in salt stress adaptation [ 66 ]. CTIMC (AT3G55440), which encodes triosephosphate isomerase (TPI), plays an essential role in redox regulation and is induced in response to salt stress by reactive carbonyl species (RCS). CTIMC protein forms a complex...”
- “...Succinate dehydrogenase subunit 5, mitochondrial 28.15/ 6.19 15 410 1.50 10 34 5.433 46, 48 AT3G55440 CTIMC Triosephosphate isomerase, cytosolic 27.38/ 5.39 26 904 5.90 10 84 1.155 47 AT5G20720 CPN20 20 kDa chaperonin, chloroplastic 26.79/ 8.86 8 87 0.033 1.638 49 AT5G26667 UMK3 P-loop containing...”
- Magnetic Field Induced Changes in the Shoot and Root Proteome of Barley (Hordeum vulgare L.)
Shabrangy, Frontiers in plant science 2021 - “...a cis-aconitate intermediate AT2G05710 ADD62592 A0A287S1D0 Triosephosphate isomerase 1.83 0.0009 11 81.66 Encodes triosephosphate isomerase. AT3G55440 CAC14917 A0A287L247 PNP-UDP-1 domain-containing protein 1.96 0.001 6 118.56 PNP_UDP_1 domain-containing protein AT4G28940 NA F2CWX3 Allene oxide synthase 0.53 0.002 22 90.98 Encodes a member of the cytochrome p450 CYP74...”
- Shotgun proteomics of peach fruit reveals major metabolic pathways associated to ripening
Nilo-Poyanco, BMC genomics 2021 - “...GLUCOSE-1-PHOSPHATE ADENYLYLTRANSFERASE SMALL SUBUNIT, CHLOROPLASTIC AT5G48300 Prupe.6G076300 1 3 Qualit_O1 Triose-phosphate isomerase / Triosephosphate mutase AT3G55440 Prupe.1G196700 1 5 Qualit_O1 Probable fructokinase-2 AT1G06030 Prupe.1G354000 1 2 Qualit_O1 1,4-alpha-glucan-branching enzyme 1, chloroplastic/amyloplastic AT5G03650 Prupe.1G376200 1 6 Up_O1 GLUCOSE-1-PHOSPHATE ADENYLYLTRANSFERASE LARGE SUBUNIT 2, CHLOROPLASTIC AT1G27680 Prupe.1G378500 0.998 2...”
- A Mutation in CsYL2.1 Encoding a Plastid Isoform of Triose Phosphate Isomerase Leads to Yellow Leaf 2.1 (yl2.1) in Cucumber (Cucumis Sativus L.)
Xiong, International journal of molecular sciences 2020 - “...A. thaliana , there are two genes annotated as TPI: one is cytosolic TPI (cytoTPI, At3g55440 ), localized to the cytoplasm; the other is the plastid isoform of TPI (pdTPI, At2g21170 ) localized to the plastid. Chen et al. discovered a knock-down mutant for pdTPI that...”
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- S-Nitrosylated Proteins Involved in Autophagy in Triticum aestivum Roots: A Bottom-Up Proteomics Approach and In Silico Predictive Algorithms
Mazina, Life (Basel, Switzerland) 2023 - “...rRNA 2-O-methyltransferase fibrillarin 1 252 Q9SVM4 Serine hydroxymethyltransferase 5 324 O48661 Spermidine synthase 2 43 P48491 Triosephosphate isomerase cytosolic 13, 127 Q9ZUY6 UDP-D-apiose/UDP-D-xylose synthase 1 187 Q9SGE0 UDP-D-apiose/UDP-D-xylose synthase 2 187 life-13-02024-t002_Table 2 Table 2 List of the proteins included in the STRING proteinprotein interaction network:...”
- “...Q9FEF8 SHM5 Serine hydroxymethyltransferase 5 Q9SVM4 SDS2 Spermidine synthase 2 O48661 TPI Triosephosphate isomerase cytosolic P48491 AXS1 UDP-D-apiose/UDP-D-xylose synthase 1 Q9ZUY6 ATG1a Serine/threonine-protein kinase ATG1a Q94C95 ATG2 Autophagy-related protein 2 F8S296 ATG3 Autophagy-related protein 3 Q0WWQ1 ATG4a Cysteine protease ATG4a Q8S929 ATG5 Autophagy protein 5 Q9FFI2...”
- Proteome Landscape during Ripening of Solid Endosperm from Two Different Coconut Cultivars Reveals Contrasting Carbohydrate and Fatty Acid Metabolic Pathway Modulation
Félix, International journal of molecular sciences 2023 - “...II and IV ( Figure 5 C and Figure S3 ). In contrast, triose-phosphate isomerase (P48491) doubled its amount in the mature stage (log2FC +1.07) ( Figure 5 B,C and Figure S3 ). Regarding glycolysis in the MPT cultivar, most glycolytic enzymes increased as maturity progressed....”
- Chlorophyll a Fluorescence Transient and 2-Dimensional Electrophoresis Analyses Reveal Response Characteristics of Photosynthesis to Heat Stress in Malus. 'Prairifire'.
Wang, Plants (Basel, Switzerland) 2020 - “...Fold Change 1 PREDICTED: thioredoxin H-type gi|657970853 P29448 0.445 2 PREDICTED: triosephosphate isomerase, cytosolic-like gi|657943968 P48491 0.292 3 PREDICTED: 2-Cys peroxiredoxin BAS1, chloroplastic-like gi|657999067 Q9C5R8 0.486 4 PREDICTED: ATP-dependent zinc metalloprotease FTSH 2, chloroplastic gi|658053518 O80860 0.344 5 PREDICTED: chlorophyll a-b binding protein of LHCII type...”
- Profiling of advanced glycation end products uncovers abiotic stress-specific target proteins in Arabidopsis
Chaplin, Journal of experimental botany 2019 - “...HIGH CYCLIC ELECTRON FLOW 1 P25851 AT3G54050 11 - 13 CYTOSOLIC ISOFORM TRIOSE PHOSPHATE ISOMERASE P48491 AT3G55440 10 - 13 ASCORBATE PEROXIDASE 4, THYLAKOID LUMEN 29, P82281 AT4G09010 12 - 13 ATP SYNTHASE SUBUNIT 1 P92549 ATMG01190 11 - 13 HYDROXYMETHYLBILANE SYNTHASE Q43316 AT5G08280 10 -...”
- “...weeks/6 weeks A2 Q8W4H7 AT1G07930 1.92 CAT2 P25819 AT4G35090 2.47 CICDH Q9SRZ6 AT1G65930 1.8 CTIMC P48491 AT3G55440 2.36 CYP18-4 Q42406 AT4G34870 2.78 FBP P25851 AT3G54050 2.26 GGAT1 Q9LR30 AT1G23310 2.99 GLU1 Q9ZNZ7 AT5G04140 2.03 GSA2 Q42522 AT3G48730 1.77 LOX2 P38418 AT3G45140 1.44 P25697 P25697 AT1G32060 1.46...”
- PAMP Activity of Cerato-Platanin during Plant Interaction: An -Omic Approach
Luti, International journal of molecular sciences 2016 - “...O80934 Uncharacterized protein At2g37660 15 48 204 8.4/34.9 Unknown Chloroplast Defense response to bacterium 17 P48491 Triosephosphate isomerase 9 47 126 5.4/27.3 Metabolism Cytoplasm Carbohydrate metabolic process 18 O03042 RuBisCO large chain (fragment 147479) 14 30 (75.9) 209 5.9/53.4 (6.4/37.3) Photosynthesis Chloroplast Photorespiration 20 P27140 Beta...”
- Quantitative proteomic analysis of the Salmonella-lettuce interaction
Zhang, Microbial biotechnology 2014 - “...of unique peptides Pyruvate dehydrogenase E1 subunit beta-1 Q38799 PDH2 7.5 <1.0E-04 2 Triosephosphate isomerase P48491 CTIMC 2.3 1.9E-02 2 Fructose-bisphosphate aldolase 1 F4IGL7 FBA1 7.2 5.8E-03 1 2-cys Peroxiredoxin Q96291 BAS1 10.0 5.5E-04 1 Actin 4 P53497 ACT12 3.5 2.4E-02 1 Nucleoside diphosphate kinase P39207...”
- Changes in the effective gravitational field strength affect the state of phosphorylation of stress-related proteins in callus cultures of Arabidopsis thaliana
Barjaktarović, Journal of experimental botany 2009 - “...12 252 5 2.19 Metabolism 13r BAB11233 6-phosphogluconolactonase 28 5.44 17 335 6 2.6 28r NP_191104 Triose phosphate isomerase 27.2 5.39 28 392 6 appear 30r NP_181187 Fructose-bisphosphate aldolase 38.4 7.01 33 676 14 0.38 1r AAB60731 Phosphoglycerate mutase 62.6 5.36 24 895 17 4.07 2r...”
P46225 Triosephosphate isomerase, chloroplastic from Secale cereale
42% identity, 82% coverage
Q5CSE7 triose-phosphate isomerase (EC 5.3.1.1) from Cryptosporidium parvum (see paper)
XP_628120, cgd1_3040 triosephosphate isomerase from Cryptosporidium parvum Iowa II
38% identity, 100% coverage
- Structure of triosephosphate isomerase from Cryptosporidium parvum
Nguyen, Acta crystallographica. Section F, Structural biology and crystallization communications 2011 - “...Methods 2.1. Protein expression and purification The gene encoding the full-length (Met1Gln250) triosephosphate isomerase (UniProt Q5CSE7; residues 1250) was PCR-amplified in a96-well format using genomic DNA as the template. The primers were designed with an additional ligase-independent cloning (LIC; Aslanidis & de Jong, 1990 ) sequence...”
- Structure of triosephosphate isomerase from Cryptosporidium parvum.
Nguyen, Acta crystallographica. Section F, Structural biology and crystallization communications 2011 - GeneRIF: 1.55 A resolution crystal structure of the open-loop form of triosephosphate isomerase from C. parvum Iowa II is presented. An unidentified electron density was found in the active site
- Identification of putative cis-regulatory elements in Cryptosporidium parvum by de novo pattern finding
Mullapudi, BMC genomics 2007 - “...cgd7_480 Phosphoglucomutase PGM 606 cgd7_4270* Pyruvate kinase PyK 718 cgd1_2040 Triose Phosphate Isomerase TPI 500 cgd1_3040 NUCLEOTIDE SALVAGE Inosine monophosphate dehydrogenase IMPDH 1065 cgd6_20* Adenosine Transporter AT 879 cgd2_310 Cytidine Triphosphate Synthase CTPS 856 cgd5_1710 Guanidine Monophosphate Synthase GMPS 423 cgd5_4520* RibonucleosideDiphosphate Reductase RDPR 627 cgd6_1950...”
Q90XG0 Triosephosphate isomerase B from Danio rerio
42% identity, 98% coverage
- Metallomic Approach to Mercury and Selenium in the Liver Tissue of Psectrogaster amazonica and Raphiodon vulpinus from the Brazilian Amazon.
Bataglioli, International journal of molecular sciences 2024 - “...25.32 0.3000 R. vulpinus 1 O73872 Superoxide dismutase [Cu-Zn] 615.6831 22.11 0.3100 34.82 0.4600 4 Q90XG0 Triosephosphate isomerase B 1373.102 24.20 0.3600 39.20 0.5100 6 Q90XG0 Triosephosphate isomerase B 4885.841 23.12 0.3300 37.60 0.4900 8 Q6NY77 4-hydroxy-2-oxoglutarate aldolase_ mitochondrial 126.5413 21.43 0.2800 33.73 0.4300 10 P83751...”
- Transcriptome analysis of genes and pathways associated with metabolism in Scylla paramamosain under different light intensities during indoor overwintering.
Li, BMC genomics 2020 - “...In the HL group, the three most highly down-regulated genes were triosephosphate isomerase B (ID: Q90XG0 0.33-fold), aconitate hydratase (ID: Q99KI0; 0.37-fold), and glyceraldehyde-3-phosphate dehydrogenase (ID: P56649; 0.38-fold) (Table 1 ). Glycine, serine and threonine metabolism (ko00260) and beta-Alanine metabolism (ko00410) are important pathways in amino...”
- “...dehydrogenase P56649 0.2565 0.0006 0.3811 0.0061 Glucose-6-phosphatase O42153 0.4234 0.0031 0.4551 0.0040 Triosephosphate isomerase B Q90XG0 0.3375 0.0002 0.3313 1.10E-05 Acetyl-coenzyme A synthetase Q9NR19 0.5993 0.0439 L-lactate dehydrogenase Q95028 0.5656 0.0288 Pyruvate dehydrogenase protein X component Q8BKZ9 0.4991 0.0309 Hexokinase type 2 Q9NFT7 0.2888 0.0282 Citrate...”
- Analysis of Proteins Associated with Quality Deterioration of Grouper Fillets Based on TMT Quantitative Proteomics during Refrigerated Storage.
Zhang, Molecules (Basel, Switzerland) 2019 - “...biosynthesis of antibiotics, glycolysis, and fructose and mannose metabolism (for detailsm, see Figure S1 ). Q90XG0, Q5MJ86, P51903, and Q90474, which are all related to glycolysis, had a relatively high degree of connectivity. B5DGM7 (Fructose-bisphosphate aldolase A) might be the key point of the whole metabolic...”
- “...which might be why hemopexin was significantly related to b * value. 2.7.2. Metabolic Enzyme Q90XG0 (triose-phosphate isomerase) plays an important role in glycolysis. It is indispensable for effective energy generation. The reversible interconversion of dihydroxyacetone phosphate (DHAP) and glyceraldehyde phosphate is catalyzed by triose-phosphate isomerase...”
- Chronic wounds alter the proteome profile in skin mucus of farmed gilthead seabream
Cordero, BMC genomics 2017 - “...(0.3) NVSEAVANSVR (0.0059) KNVSEAVANSVR (1200) GAFTGEISPAMIK (4.9) FGVAAQNCYK (11) H16 Triosephosphate isomerase B D. rerio Q90XG0 6.5/27.1 76/12 3/3 FFVGGNWK (0.065) GAFTGEISPAMIK (5.7*10 7 ) WVILGHSER (0.037) H17 Triosephosphate isomerase B D. rerio Q90XG0 6.5/27.1 131/23 5/5 FFVGGNWK (6.1) GAFTGEISPAMIK (1.7*10 6 ) WVILGHSER (0.001) HVFGESDELIGQK...”
W9R6S4 Triosephosphate isomerase from Morus notabilis
LOC21407669 triosephosphate isomerase, chloroplastic from Morus notabilis
42% identity, 76% coverage
B7FSQ0 Triosephosphate isomerase from Phaeodactylum tricornutum (strain CCAP 1055/1)
41% identity, 83% coverage
- Metabolomic, proteomic and lactylated proteomic analyses indicate lactate plays important roles in maintaining energy and C:N homeostasis in Phaeodactylum tricornutum
Huang, Biotechnology for biofuels and bioproducts 2022 - “...0.51 0.04 50 B7G585 Pyruvate, orthophosphate dikinase 0.48 0.02 0.60 0.04 Calvin cycle, glycolysis 2 B7FSQ0 Triosephosphate isomerase 0.49 0.12 0.33 0.00 3 B7FSI3 Glyceraldehyde 3-phosphate dehydrogenase 0.79 0.13 0.57 0.00 5 B7G938 Phosphoglycerate kinase 0.79 0.11 0.69 0.00 8 B7FSI4 Glyceraldehyde 3-phosphate dehydrogenase 0.72 0.16...”
- Proteomic and biochemical responses to different concentrations of CO2 suggest the existence of multiple carbon metabolism strategies in Phaeodactylum tricornutum
Wu, Biotechnology for biofuels 2021 - “...(GPI, B7GDK9), fructose-1,6-diphosphate aldolase (FBAase, Q84X64, Q84XB5, B7GE67), aldolase (B7FRC1, B7G4R3), triose phosphate isomerase (TIM, B7FSQ0, B7G3C1), GAPDH (Q9M7R3, B7FSI4), PGK (B8LCF8, B7G938), phosphoglycerate mutase (PGAM, B7GEI2, B7FU06), plastic enolase (B7GEF2), pyruvate kinase (PK, Q2TSX0, Q2TSW9) and pyruvate dehydrogenase complex-related proteins (B7FZN6, B7FZE1, B7GDA9) were upregulated...”
TPIS_BARHE / Q8L1Z5 Triosephosphate isomerase; TIM; TPI; Triose-phosphate isomerase; EC 5.3.1.1 from Bartonella henselae (strain ATCC 49882 / DSM 28221 / CCUG 30454 / Houston 1) (Rochalimaea henselae)
Q8L1Z5 triose-phosphate isomerase (EC 5.3.1.1) from Bartonella henselae (see paper)
38% identity, 97% coverage
- function: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P).
catalytic activity: D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate (RHEA:18585)
subunit: Homodimer.
S6FMC3 Triosephosphate isomerase from Litomosoides sigmodontis
43% identity, 98% coverage
CE557_402 triose-phosphate isomerase from Cardinium endosymbiont of Sogatella furcifera
37% identity, 98% coverage
W9S728 Triosephosphate isomerase, cytosolic from Morus notabilis
41% identity, 99% coverage
M7Z1M4 Triosephosphate isomerase, chloroplastic from Triticum urartu
42% identity, 88% coverage
P48496 Triosephosphate isomerase, chloroplastic from Spinacia oleracea
42% identity, 76% coverage
- Redox Conformation-Specific Protein-Protein Interactions of the 2-Cysteine Peroxiredoxin in Arabidopsis.
Liebthal, Antioxidants (Basel, Switzerland) 2020 - “...1 Q9LEJ0 ATP-dependent DNA helicase homolog RECG Q9ZVG0 LlFtsZ protein Q9LRC5 Transketolase O20250 Triosephosphate isomerase P48496 * Ribulose-phosphate 3-epimerase Q43157 D-3-phosphoglycerate dehydrogenase Q9FSS6 O-acetylserine (thiol)-lyase B P32260 28 kDa ribonucleoprotein P28644 * Elongation factor Tu Q43467 Elongation factor G-1 P34811 * 30S ribosomal protein S1 P29344...”
- Protein profile of Beta vulgaris leaf apoplastic fluid and changes induced by Fe deficiency and Fe resupply
Ceballos-Laita, Frontiers in plant science 2015 - “...Translation CARBON METABOLISM (27) 4 Enolase Q43130 nCS Glycolytic process 4 Triosephosphate isomerase B0LT90, K4FXE7, P48496 , , C , nCS, nCS Glycolytic process 11 Fructose-bisphosphate aldolase F1AHC9, O04975, Q6RSN7 C, , nCS, nCS, Glycolytic process 1 2,3-Bisphosphoglycerate-independent phosphoglycerate mutase Q42908 Glycolytic process 1 Phosphoglucomutase P93262...”
- An iTRAQ-based proteomics approach to clarify the molecular physiology of somatic embryo development in Prince Rupprecht's larch (Larix principis-rupprechtii Mayr).
Zhao, PloS one 2015 - “...Cluster c Primary metabolic process Triosephosphate isomerase D5AAB7 1 0.352 7.143 2 Triosephosphate isomerase, chloroplastic P48496 1 0.325 7.336 2 Citrate synthase B8LLL1 1 0.969 0.579 1 6-phosphogluconate dehydrogenase, decarboxylating E3V1H6 1 1.267 1.326 4 6-phosphogluconate dehydrogenase family protein Q9SH69 1 0.776 1.350 4 Glyceraldehyde-3-phosphate dehydrogenase...”
- “...especially those related to carbon and nitrogen metabolism. Two glycolytic enzymes, triosephosphate isomerase (TIM; D5AAB7, P48496) and glyceraldehyde 3-phosphate dehydrogenase (GAPDH, Q5E924), and one enzyme involved in the tricarboxylic acid cycle (TCA cycle), citrate synthase (B8LLL1), exhibited changes in expression during somatic embryo development. While TIM...”
- Proteomics gives insight into the regulatory function of chloroplast thioredoxins
Balmer, Proceedings of the National Academy of Sciences of the United States of America 2003 - “...right column, starting with transketolase, are O20250, P48496, Q43157, Q9FSS6, P32260, P28644, Q43467, P34811, P29344, P82403, Q94KU2. *The first number...”
MPN629 triosephosphate isomerase from Mycoplasma pneumoniae M129
42% identity, 97% coverage
Q6SA19 Triosephosphate isomerase from Rattus norvegicus
44% identity, 98% coverage
1ssgA / P00940 Understanding protein lids: structural analysis of active hinge mutants in triosephosphate isomerase (see paper)
43% identity, 98% coverage
- Ligand: 2-phosphoglycolic acid (1ssgA)
TPIS_CANAL / Q9P940 Triosephosphate isomerase; TIM; Triose-phosphate isomerase; EC 5.3.1.1 from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (see paper)
TPI1 triosephosphate isomerase (TIM); EC 5.3.1.1 from Candida albicans (see 7 papers)
42% identity, 98% coverage
NP_001080476 triosephosphate isomerase from Xenopus laevis
42% identity, 98% coverage
LOC107795534 triosephosphate isomerase, cytosolic-like from Nicotiana tabacum
41% identity, 99% coverage
LOC104605564 triosephosphate isomerase, chloroplastic-like from Nelumbo nucifera
42% identity, 78% coverage
P48494 Triosephosphate isomerase, cytosolic from Oryza sativa subsp. japonica
41% identity, 99% coverage
- Relationship between Protein, MicroRNA Expression in Extracellular Vesicles and Rice Seed Vigor
Wu, International journal of molecular sciences 2024 - “...and most abundance P37833 Aspartate aminotransferase, cytoplasmic Most enriched pathway or terms and most abundance P48494 Triosephosphate isomerase, cytosolic Most enriched pathway or terms and Most abundance Q53MW2 Non-specific lipid-transfer protein Most abundance O82451 Probable glutathione S-transferase GSTF2 Most abundance Q33AE4 Phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) Most enriched pathway...”
- Physiological and Proteome Analysis of the Effects of Chitosan Oligosaccharides on Salt Tolerance of Rice Seedlings
Qian, International journal of molecular sciences 2024 - “...A0A0E0CY82 3.1.3.11 K03841 Q9SDL8 6.2.1.1 K01895 Q7F8W1 5.3.1.1 K01803 A0A0E0B5S4 5.4.2.12 K15633 B8AZB8 5.3.1.1 K01803 P48494 5.4.2.12 K15633 A0A0E0FUX9 5.4.2.12 K15633 A0A0E0FUX9 4.1.1.49 K01610 A0A0E0CY82 Stem 2.7.1.1 K00844 A0A0D3G422 2.7.1.1 K00844 A0A0E0DZ42 5.1.3.3 K01785 Q33AZ5 5.1.3.3 K01785 A0A0P0WB27 5.1.3.15 K01792 A2YZX3 2.7.1.90 K00895 I1P3K4 2.7.1.90 K00895...”
- Data on bioactive peptides derived from chicken hydrolysate with potential alcohol dehydrogenase stabilizing activity and in silico analysis of their potential activity and applicability.
Xiao, Data in brief 2020 - “...Q9SLY8 Non-Toxin 0.69 0.67 0.34 0.29 3.26 1407.55 26 MVVDGVKLM 0.25 non-allergen UniProtKB accession number P48494 Non-Toxin 1.03 0.7 0.41 0.11 6.19 990.52 27 NFPTYDGKDRVIDL 0.23 non-allergen UniProtKB accession number Q9H0F7 Non-Toxin 1.15 0.66 0.44 0.24 4.43 1651.82 28 DNHEALELL 0.23 non-allergen UniProtKB accession number Q9S8F6...”
- Proteomic Analysis Reveals Different Involvement of Embryo and Endosperm Proteins during Aging of Yliangyou 2 Hybrid Rice Seeds
Zhang, Frontiers in plant science 2016 (no snippet) - Comparison of leaf proteomes of cassava (Manihot esculenta Crantz) cultivar NZ199 diploid and autotetraploid genotypes
An, PloS one 2014 - “...thaliana 2.520.14(+) AAD29799 7.67/33.35 63/1 46 Triose phosphate isomerase, cytosolic - Oryza sativa subsp.japonica 3.530.11(+) P48494 5.38/27.06 63/1 47 Putative ATP-binding protein - Stenotrophomonas maltophilia K279a 2.080.07() CAQ46869 5.87/30.40 88/1 48 Putative ATP-binding protein - S. maltophilia K279a 2.020.06() CAQ46869 5.87/30.40 88/1 49 Putative ATP-binding protein...”
- Proteome Analysis of Rice (Oryza sativa L.) Mutants Reveals Differentially Induced Proteins during Brown Planthopper (Nilaparvata lugens) Infestation
Sangha, International journal of molecular sciences 2013 - “...14 (49) Enolase gi780372 39.9(47.9) 6.7(5.4) 104 7.95 0.0522 TP 8(25) Triose phosphate isomerase, cytosolic P48494 27.5(27.1) 5.6(5.4) 70 <10 <0.0001 9 6(33) Glyceraldehyde-3- phosphate dehydrogenase, cytosolic G3PC_HORV 37.4(33.2) 6.7(6.2) 258 9.6 0.0090 44 6(27) Putative dihydrolipoamide dehydrogenase precursor gi34894800 57.0(52.6) 6.6(7.2) 111 <10 0.0011 35...”
RL2513 putative triosephosphate isomerase from Rhizobium leguminosarum bv. viciae 3841
43% identity, 96% coverage
- Factors governing attachment of Rhizobium leguminosarum to legume roots at acid, neutral, and alkaline pHs
Parsons, mSystems 2024 - “...to form adenine and ribose 5-phosphate RL2400 b Putative MarC family transmembrane protein, unknown function RL2513 tpiA Putative triosephosphate isomerase TpiA RL2637 recA DNA repair and SOS response RecA RL3322 pfp Putative pyrophosphate-fructose 6-phosphate 1-phosphotransferase RL3752 a pssA Glycosyl transferase involved in EPS biosynthesis RL3766 rpoH1...”
- “...and 7.0 RL2044 scpA Segregation and condensation protein A participates in chromosomal division pH 7.0 RL2513 tpiA Putative triosephosphate isomerase TpiA pH 6.5, 7.0, and 7.5 RL2520 Permease, transmembrane protein pH 6.5 and 7.0 RL2587 anmK Anhydro-N-acetylmuramic acid kinase AnmK. Required for cell wall recycling pH...”
- Factors governing attachment ofRhizobium leguminosarumto legume roots
Parsons, 2022 - Role of O2 in the Growth of Rhizobium leguminosarum bv. viciae 3841 on Glucose and Succinate
Wheatley, Journal of bacteriology 2017 - “...zwf gpmB zwf gltA eno pdhA pdhC RL2508 RL2509 RL2513 gltA citA tpiA RL2631 RL2701 RL2703 RL4007 RL4011 RL4060 RL4114 RL4115 RL4116 RL4117 RL4118 RL4162 RL4433...”
- “...(gene[s]) or pathways Triosephosphate isomerase (pRL120209, RL2513) GD Methylglyoxal synthase (RL0183) NE Methylglyoxal reductase (pRL120760, RL3064, RL3243) NE...”
- The Use of Transposon Insertion Sequencing to Interrogate the Core Functional Genome of the Legume Symbiont Rhizobium leguminosarum
Perry, Frontiers in microbiology 2016 - “...pRL120196 Fructose-1,6-bisphosphate aldolase PGN 0.95 20.67 NE 1 22.53 NE 3.3.9 Putative fructose-bisphosphate aldolase 2.4 RL2513 tpiA Triosephosphate isomerase GN 0.9 14.56 NE 0.9 24.22 NE 3.6.0 Putative triosephosphate isomerase 2.4 pRL120209 tpiA Triosephosphate isomerase PVGI 0.38 2.33 GD 0.88 8.14 NE 3.6.0 Putative triosephosphate isomerase...”
- “...to be PGI when grown on mannitol as a sole carbon source. Their chromosomal homologs RL2513 ( tpiA ) and RL2547 ( rpiB ) were both observed to be GN (Table 2 ). In a closely related R. leguminosarum bv. viciae strain VF39, the homologs of...”
F2EHF8 Triosephosphate isomerase, cytosolic from Hordeum vulgare subsp. vulgare
43% identity, 99% coverage
- Common Post-translational Modifications (PTMs) of Proteins: Analysis by Up-to-Date Analytical Techniques with an Emphasis on Barley
Bobalova, Journal of agricultural and food chemistry 2023 - “...isomerase2 Q9AYT7 28669 106 NITD S107-p, S194-p 26 kDa endochitinase2 P23951 28156 K132(Hex1) triosephosphate isomerase F2EHF8 26779 S192-p 2-Cys peroxiredoxin BAS1, chloroplastic Q96468 23299 S106-p, S127-p calmodulin P62162 16832 S54-p, S82-p, T80-p nucleoside diphosphate kinase F2CXV3 16646 S118-p, T92-p, T5-p 4.4 Alternative Modifications Thanks to rapid...”
- Proteomic Response of Hordeum vulgare cv. Tadmor and Hordeum marinum to Salinity Stress: Similarities and Differences between a Glycophyte and a Halophyte
Maršálová, Frontiers in plant science 2016 - “...of twelve glycolytic enzymes were identified including fructose bisphosphate aldolase (ALDO; F2CXT7), triosephosphate isomerase (TPI; F2EHF8, M0WDD4), glyceraldehyde-3-phosphate dehydrogenase 2 (GAPDH; F2D6I8), phosphoglycerate kinase (PGK; M0Y9H9), PGM (M0WLI6), and ENO (M0WLI6). A significant decrease in relative abundance of four glycolytic proteins detected (ALDO, ENO, PGM, and...”
CIMG_09361 triosephosphate isomerase from Coccidioides immitis RS
42% identity, 95% coverage
E3JPZ9 Triosephosphate isomerase from Puccinia graminis f. sp. tritici (strain CRL 75-36-700-3 / race SCCL)
PGTG_00038 triosephosphate isomerase from Puccinia graminis f. sp. tritici CRL 75-36-700-3
40% identity, 99% coverage
Q5S7Y5 triose-phosphate isomerase (EC 5.3.1.1) from Chlamydomonas reinhardtii (see paper)
CHLREDRAFT_26265, XP_001690035 uncharacterized protein from Chlamydomonas reinhardtii
41% identity, 88% coverage
- Quantitative Phosphoproteomic and System-Level Analysis of TOR Inhibition Unravel Distinct Organellar Acclimation in Chlamydomonas reinhardtii
Roustan, Frontiers in plant science 2018 - “...to control cells. In contrast, proteins related to Calvin-cycle and photorespiration, such as A8HP84, A8IRK4, Q5S7Y5, and A8IVM9, were found to be down-regulated during rapamycin treatment. As well, several proteases were found to be differentially regulated during the rapamycin treatment. For instance, metalloprotease (A8IL08 and A8J6C7)...”
- Comprehensive Time-Course Transcriptome and Co-expression Network Analyses Identify Salt Stress Responding Mechanisms in Chlamydomonas reinhardtii Strain GY-D55
Zhang, Frontiers in plant science 2022 - “...then converted to dihydroxyacetone-phosphate (DHAP) by triosephosphate isomerase ( Shetty et al., 2019 ) (TIM, CHLREDRAFT_26265). These two genes are mainly expressed at 24 h under salt stress in GY-D55 cells. Then, DHAP is converted to glycerol-3-phosphate (G3P) by glycerol-3-phosphate dehydrogenase (G3PDH). There are five isoforms...”
- High-resolution crystal structure and redox properties of chloroplastic triosephosphate isomerase from Chlamydomonas reinhardtii.
Zaffagnini, Molecular plant 2014 (PubMed)- GeneRIF: crystal structure and redox properties of chloroplastic triosephosphate isomerase
BTH_I1058 triosephosphate isomerase from Burkholderia thailandensis E264
39% identity, 100% coverage
- Combining functional and structural genomics to sample the essential Burkholderia structome
Baugh, PloS one 2013 - “...structures B. pseudomallei BTH_I0878 Yes BTH_I0882 Glutamine dependent NAD+ synthetase 4F4H B. thailandensis BTH_I0882 Yes BTH_I1058 Triosephosphate isomerase 4G1K B. thailandensis BTH_I1058 P60174 41.5, 99.2 Yes BamMC406_0490 D-alanineD-alanine ligase (ddl) 4EG0 B. ambifaria BTH_I1120 Yes Bxe_A0488 4EGJ B. xenovorans Yes BTH_I1195 Transketolase (tkt) 3UK1, 3UPT B....”
HPODL_03187 Triosephosphate isomerase from Ogataea parapolymorpha DL-1
40% identity, 98% coverage
Q0H294 triose-phosphate isomerase (EC 5.3.1.1) from Pteris vittata (see paper)
42% identity, 99% coverage
I3SN66 Triose-phosphate isomerase from Medicago truncatula
40% identity, 79% coverage
D0G7F6 Triosephosphate isomerase from Sus scrofa
43% identity, 98% coverage
P48500 Triosephosphate isomerase from Rattus norvegicus
NP_075211 triosephosphate isomerase from Rattus norvegicus
44% identity, 98% coverage
- Influence of the Degree of Unsaturation in Fish Oil Supplements on Oxidative Stress and Protein Carbonylation in the Cerebral Cortex and Cerebellum of Healthy Rats
Moreno, Antioxidants (Basel, Switzerland) 2024 - “...Rattus norvegicus OX = 10116 GN = Tpi1 PE = 1 SV = 2 Tpi1 P48500 Cortex 1.38 (0.15) 2.78 (0.41) Cerebellum 1.20 (0.25) 1.61 * (0.45) Glyceraldehyde-3-phosphate dehydrogenase OS = Rattus norvegicus OX = 10116 GN = Gapdh PE = 1 SV = 3 Gapdh...”
- The Traf2 and NcK interacting kinase inhibitor NCB-0846 suppresses seizure activity involving the decrease of GRIA1
Wang, Genes & diseases 2024 - “...alpha 25400 Camk2a 11 P11730 Calcium/calmodulin-dependent protein kinase type II subunit gamma 171140 Camk2g 12 P48500 Triosephosphate isomerase 24849 Tpi1 13 P15791 Calcium/calmodulin-dependent protein kinase type II subunit delta 24246 Camk2d 14 P62260 14-3-3 protein epsilon 29753 Ywhae 15 G3V8Q2 Alpha-internexin 24503 Ina 16 Q71DI1 Dermcidin...”
- Hyperhomocysteinemia-Induced Alterations in Protein Expression and Oxidative Stress Parameters in Rat Heart.
Tatarková, Physiological research 2024 - Charcot-Marie-Tooth-1A and sciatic nerve crush rat models: insights from proteomics
Msheik, Neural regeneration research 2023 - “...P12839, P47942, F1M614 5.39 0.00195 Nicotinamide nucleotide metabolic process 7 4.90E-05 Q9R063, P04636, P42123, Q9EQS0, P48500, P04764, P26284 10.59 0.00562 Pyridine nucleotide metabolic process 7 4.91E-05 Q9R063, P04636, P42123, Q9EQS0, P48500, P04764, P26284 10.59 0.00562 Oxidoreduction coenzyme metabolic process 7 9.40E-05 Q9R063, P04636, P42123, Q9EQS0, P48500,...”
- Local glycolysis fuels actomyosin contraction during axonal retraction
Santos, The Journal of cell biology 2023 - “...F1M0Z1 8.00 98.86 Glycolysis (investment phase) GPI Glucose-6-phosphate isomerase Q6P6V0 12.37 100 TPI1 Triosephosphate isomerase P48500 31.73 48.23 Glycolysis (payoff phase) GAPDH Glyceraldehyde-3-phosphate dehydrogenase P04797 41.44 44.26 PGK1 Phosphoglycerate kinase 1 P16617 39.81 84.60 PGAM1 Phosphoglycerate mutase 1 P25113 33.46 100 PGAM2 Phosphoglycerate mutase 2 P16290...”
- Chronic Cerebral Hypoperfusion-Induced Disturbed Proteostasis of Mitochondria and MAM Is Reflected in the CSF of Rats by Proteomic Analysis
Tukacs, Molecular neurobiology 2023 - “...P09117 Aldoc 1.31 Fructose-bisphosphate aldolase C Glycolysis Cytoplasm P04797 Gapdh 1.38 Glyceraldehyde-3-phosphate dehydrogenase Glycolysis Cytoplasm P48500 Tpi1 1.22 Triosephosphate isomerase Glycolysis Cytoplasm D3ZVD3 Nt5c1a 1.41 5'-nucleotidase, cytosolic IA Nucleotide metabolism Cytoplasm Protein turnover and import P63018 Hspa8 2.38 Heat shock cognate 71kDa protein Protein folding Cytoplasm...”
- Proteome analysis of urinary biomarkers in a cigarette smoke-induced COPD rat model.
Qin, Respiratory research 2022 - “...0.66 None P04937 Fibronectin 1.81 P02751 P08649 Complement C4 0.43 P0C0L4 P24090 Alpha-2-HS-glycoprotein 0.39 None P48500 Triosephosphate isomerase 0.48 P60174 Q4QQW8 Putative phospholipase B-like 2 2.65 Q8NHP8 Q5M876 N-acyl-aromatic- l -amino acid amidohydrolase 1.78 Q96HD9 Q64230 Meprin A subunit alpha 1.69 Q16819 Q6P7A9 Lysosomal alpha-glucosidase 0.47...”
- Role of Glycolysis/Gluconeogenesis and HIF-1 Signaling Pathways in Rats with Dental Fluorosis Integrated Proteomics and Metabolomics Analysis.
Ba, International journal of molecular sciences 2022 - “...P16290 2.20 10 9 1.43 Eno3 Beta-enolase P15429 1.35 10 7 1.40 Tpi1 Triosephosphate isomerase P48500 2.95 10 4 1.29 Aldoa Fructose-bisphosphate aldolase A P05065 3.32 10 11 0.69 Tfrc transferrin receptor Q99376 1.03 10 9 1.25 Rps6 ribosomal protein s6 P62755 1.18 10 2 1.82...”
- More
- Metabolic Enzyme Triosephosphate Isomerase 1 and Nicotinamide Phosphoribosyltransferase, Two Independent Inflammatory Indicators in Rheumatoid Arthritis: Evidences From Collagen-Induced Arthritis and Clinical Samples.
Lei, Frontiers in immunology 2021 - GeneRIF: Metabolic Enzyme Triosephosphate Isomerase 1 and Nicotinamide Phosphoribosyltransferase, Two Independent Inflammatory Indicators in Rheumatoid Arthritis: Evidences From Collagen-Induced Arthritis and Clinical Samples.
- The application of selective reaction monitoring confirms dysregulation of glycolysis in a preclinical model of schizophrenia.
Martins-de-Souza, BMC research notes 2012 - GeneRIF: Data show statistically significant altered levels of Tpi1 and alteration of Hk1, Aldoc, Pgam1 and Gapdh with borderline significance in phencyclidine (PCP) rats compared to controls.
- The glycolytic enzymes, glyceraldehyde-3-phosphate dehydrogenase, triose-phosphate isomerase, and pyruvate kinase are components of the K(ATP) channel macromolecular complex and regulate its function.
Dhar-Chowdhury, The Journal of biological chemistry 2005 - GeneRIF: glyceraldehyde-3-phosphate dehydrogenase, triose-phosphate isomerase, and pyruvate kinase are components of the K(ATP) channel macromolecular complex, including Kir6.2, and regulate its function
TASI_0409 triose-phosphate isomerase from Taylorella asinigenitalis MCE3
39% identity, 96% coverage
- Genomic characterization of the Taylorella genus
Hébert, PloS one 2012 - “...TEQUI_1308); 11. glutamate dehydrognase (TASI_1163, TEQUI_0187); 12. pyruvate phosphate dikinase (TASI_0871, TEQUI_1418); 13. triose-phosphate isomerase (TASI_0409, TEQUI_1037); 14. fructose-bisphosphate aldolase (TASI_1324, TEQUI_0348); 15. fructose-bisphosphatase (TASI_0582, TEQUI_1137); 16. glucose-6-phosphate isomerase (TASI_1244, TEQUI_0262); 17. transketolase (TASI_1328, TEQUI_0352). Carbon sources identified as metabolized during T.asinigenitalis MCE3 and T.equigenitalis MCE9...”
I3S3S0 Cytosolic triosephosphate isomerase from Medicago truncatula
40% identity, 99% coverage
F6I134 Triosephosphate isomerase, chloroplastic from Vitis vinifera
42% identity, 76% coverage
- Root Proteomic Analysis of Two Grapevine Rootstock Genotypes Showing Different Susceptibility to Salt Stress
Prinsi, International journal of molecular sciences 2020 - “...A5BEM8 Oxidoreductase GLYR1 (7) 2.60 100 D7TR81 Pyrophosphatefructose 6-phosphate 1-phosphotransferase subunit beta (4) 2.96 46 F6I134 Triosephosphate isomerase, chloroplastic (1, 21) 3.06 207 C0KY93 Leucoanthocyanidin dioxygenase (1, 7, 13, 16, 17, 26) 3.29 192 F6HI27 Pyruvate dehydrogenase E1 component subunit beta-2, chloroplastic (1, 8, 11) 3.75...”
Bm1_29130, XP_001897269 triosephosphate isomerase, putative from Brugia malayi
41% identity, 98% coverage
- Yeast-Based High-Throughput Screens to Identify Novel Compounds Active against Brugia malayi
Bilsland, PLoS neglected tropical diseases 2016 - “...Table 1 . The coding regions of Bm1_22900 ( Bm NMT), Bm1_01925 ( Bm PGK), Bm1_29130 ( Bm TPI), Bm1_ 49000 ( Bm PIS), Bm1_48165 ( Bm SAH), Bm1_38705 ( Bm SEC53), Bm1_11585 ( Bm ADE13) and Bm1_23075 ( Bm CDC8) were PCR-amplified from an adult...”
- “...transduction NMT1 phosphoglycerate kinase (PGK) Bm1_01925 WUBG_03621 P00558 Glycolysis, energy metabolism PGK1 triose-phosphate isomerase (TPI) Bm1_29130 WUBG_07449 P60174 Glycolysis, energy metabolism TPI1 adenosyl homocysteinase Bm1_48165 WUBG_05842 P23526 Cellular lipid homoeostasis SAH1 Inorganic pyrophosphatase Bm1_16955 WUBG_14547 Q15181 Rapid exchange of oxygen from Pi with water IPP1 Phospho...”
- The secreted triose phosphate isomerase of Brugia malayi is required to sustain microfilaria production in vivo
Hewitson, PLoS pathogens 2014 - “...is conserved in sequence and enzymatic function. A . Amino acid alignment of Bm -TPI (XP_001897269) with Ls -TPI (Hx2000032586), Ce -TPI (NP_496563), Sm -TPI (P48501), mouse TPI (NP_033441) and human TPI (NP_000356). B . Michaelis-Menten kinetics comparing activity of recombinant Bm - and Ls -TPI...”
- A potential role for the interaction of Wolbachia surface proteins with the Brugia malayi glycolytic enzymes and cytoskeleton in maintenance of endosymbiosis
Melnikow, PLoS neglected tropical diseases 2013 - “...(Accession#) a O. cuniculus (Accession#) Sequence Identity Fructose-bisphosphate aldolase Bm1_15350 EDP36623.1 NP_001075707.1 69% Triosephosphate isomerase Bm1_29130 EDP33878.1 P00939.1 62% L-lactate dehydrogenase Bm1_43730 EDP30958.1 NP_001182636.1 60% Enolase Bm1_24115 EDP34873.1 XP_002716189.1 72% Glyceraldehyde-3-phosphate dehydrogenase Bm1_41940 EDP31080.1/EDP31079.1 XP_002708267.1 69% Phosphoglycerate kinase Bm1_01925 EDP39298.1 XP_002709046.1 73% a BLAST searches were...”
- “...protein WSP YP_198262.1 wBm0432 9 Fructose-bisphosphate aldolase ** EDP36623.1 Bm1_15350 5 Triosephosphate isomerase ** EDP33878.1 Bm1_29130 4 Histone H2B EDP39185.1 Bm1_02510 3 L-lactate dehydrogenase ** EDP30958.1 Bm1_43730 3 Myotactin form B, putative EDP28983.1 Bm1_53510 3 High mobility group protein 1 EDP34582.1 Bm1_25620 3 Enolase ** EDP34873.1...”
- Human and animal dirofilariasis: the emergence of a zoonotic mosaic
Simón, Clinical microbiology reviews 2012 - “...XP_001896281 AAB52600 XP_001899850 AAV33247 XP_001891892 EDP29666 XP_001897269 XP_001900208 XP_001900957 A8NLA3 Protein Simon et al. In microfilariae, nutrient...”
- Multiplex proteomics analysis of gender-associated proteins in Brugia malayi
Jiang, International journal for parasitology 2012 - “...crystallin family Metabolism Bm1_15350 fructose-bisphosphate aldolase 1, putative PF00274 Bm1_41940 Glyceraldehyde 3-phosphate dehydrogenase, putative TIGR01534 Bm1_29130 triosephosphate isomerase, putative PF00121 Bm1_16060 carbohydrate phosphorylase, putative TIGR02093 Bm1_13790 adenylate kinase isoenzyme 1, putative TIGR01360 Bm1_50960 vacuolar ATP synthase catalytic subunit A, osteoclast isoform, putative Bm1_34625 Dihydrolipoyllysine-residue succinyltransferase component...”
- “...1 1 lc2f,lc3m Bm1_17805 1 1 2m 2 2 Bm1_16060 1 2 1 3m,f1 M<F Bm1_29130 3 2 1 Bm1_50960 2 2 2 2 1 2 Bm1_43675 1 1 2 3 2 1 3 Bm1_57260 1 1 1 1 1 Bm1_16810 3 2 1 1 3...”
- Brugia malayi excreted/secreted proteins at the host/parasite interface: stage- and gender-specific proteomic profiling
Bennuru, PLoS neglected tropical diseases 2009 - “...involved in the catabolism of immunomodulatory and pro-inflammatory cysteinyl leukotrienes [43] . Triose-phosphate isomerase (TPI Bm1_29130) an enzyme involved in the conversion of dihydroxy-acetone to glyceraldehyde-3-phosphate was specifically identified abundantly in the ES of the adult female, and not in the adult male or microfilariae. TPI...”
- Stage- and gender-specific proteomic analysis of Brugia malayi excretory-secretory products
Moreno, PLoS neglected tropical diseases 2008 - “...6 A8NQM6 Bm1_07780 13333.m00082 Immunogenic protein 3, putative Y 0.88 3.91 0.98 1.32 7 A8PKM4 Bm1_29130 14940.m00172 Triosephosphate isomerase, putative N 0.36 3.48 16.87 3.73 8 O97392 Bm1_09950 13531.m00015 Gamma-glutamyl transpeptidase precursor Y 0.69 2.75 3.35 0.81 9 A8P664 Bm1_17400 14293.m00075 Trypsin inhibitor, putative N 0.69...”
- “...Q6T8C4 - - Superoxide dismutase [Cu-Zn] N 0.39 1.74 0.58 1.17 Female worm 1 A8PKM4 Bm1_29130 14940.m00172 Triosephosphate isomerase, putative N 0.36 3.48 16.87 3.73 2 A8PJU3 Bm1_28435 14930.m00337 Bm-MIF-1, identical N 0.51 0.72 8.91 0.15 3 A8QH34 Bm1_56305 15373.m00009 Leucyl aminopeptidase, putative Y 0.86 0.58...”
TPIS_PLAFA / Q07412 Triosephosphate isomerase; PfTIM; Triose-phosphate isomerase; EC 5.3.1.1 from Plasmodium falciparum (see 7 papers)
Q07412 triose-phosphate isomerase (EC 5.3.1.1) from Plasmodium falciparum (see 13 papers)
tpi / AAA18799.1 triosephosphate isomerase from Plasmodium falciparum (see paper)
PF3D7_1439900, XP_001348552 triosephosphate isomerase from Plasmodium falciparum 3D7
38% identity, 99% coverage
- function: Catalyzes the interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate in the glycolytic and gluconeogenic pathways.
catalytic activity: D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate (RHEA:18585)
subunit: Homodimer. - Photoaffinity probe-based antimalarial target identification of artemisinin in the intraerythrocytic developmental cycle of Plasmodium falciparum
Gao, iMeta 2024 - “...study, P. falciparum l lactate dehydrogenase ( PfLDH , PF3D7_1324900), triosephosphate isomerase ( PfTIM , PF3D7_1439900), and glyceraldehyde3phosphate dehydrogenase ( PfGAPDH , PF3D7_1462800) were identified as potential targets for ART [ 20 ], and they were also identified in this work. We first validated their interaction...”
- Identification of antimalarial targets of chloroquine by a combined deconvolution strategy of ABPP and MS-CETSA
Gao, Military Medical Research 2022 - “...PF3D7_0626800 ), phosphoglycerate kinase ( Pf PGK, PF3D7_0922500 ) and triosephosphate isomerase ( Pf TPI, PF3D7_1439900 ) of P. falciparum 3D7 were synthesized commercially with codon-optimization and were cloned into pET-28a. The plasmids were transformed into Escherichia coli strain BL21. The cells were cultured in LuriaBertani...”
- “...), Pf PyrK ( PF3D7_0626800 ), Pf PGK ( PF3D7_0922500 ) and Pf TPI ( PF3D7_1439900 ). To start with, we retrieved the structures of these 5 proteins from PDB database and modelled the binding poses of CQ to them through molecular docking simulation (Fig. 4...”
- Identification of sulfenylation patterns in trophozoite stage Plasmodium falciparum using a non-dimedone based probe
Schipper, Molecular and biochemical parasitology 2021 - “...were identified as targets for sulfenylation, including 6-phosphofructokinase (PfPFK1, PF3D7_0915400), fructose-bisphosphate aldolase (Pf3D7_1444800), triosephosphate isomerase (Pf3D7_1439900), PfGAPDH (PF3D7_1462800), enolase (PF3D7_1015900), PfPK (PF3D7_0626800), and PfLDH (PF3D7_1324900). With the exception of PfPFK1 and PfLDH, homologues of the other 5 proteins were also identified as being sulfenylated in H....”
- “...L-lactate dehydrogenase (PfLDH) 34.1 74.4% / 72.5% / 71.8% C59 C260 + + SP 34 PF3D7_1439900 Triosephosphate isomerase 27.9 72.2% / 73.8% / 76.2% C217 + + 35 PF3D7_1444800 Fructose-bisphosphate aldolase 40.1 84.0% / 83.2% / 82.1% C247 + 36 PF3D7_1462800 Glyceraldehyde-3-phosphate dehydrogenase (PfGAPDH) 36.6 78.9%...”
- The apicoplast link to fever-survival and artemisinin-resistance in the malaria parasite
Zhang, Nature communications 2021 - “...synthase (IspF, PF3D7_0209300), pyruvate kinase II (PyKII, PF3D7_1037100), phosphoenolpyruvate/phosphate translocator (PPT, PF3D7_0530200), triosephosphate isomerase (TIM, PF3D7_1439900), triosephosphate transporter (TPT, PF3D7_1218400), and upstream-regulator of MEP-pathway substrates HAD1-phosphotase (HAD1, PF3D7_1033400) 58 . All direct downstream-targets prenylated by bifunctional farnesyl/geranylgeranyl diphosphate synthase (FPPS/GGPPS, PF3D7_1128400) with products of the MEP-pathway...”
- N6-Adenosine methylation on mRNA is recognized by YTH2 domain protein of human malaria parasite Plasmodium falciparum
Govindaraju, Epigenetics & chromatin 2020 - “...RNA PF3D7_0518200 SWIB/MDM2 domain-containing protein PF3D7_0214000 T-complex protein 1 subunit theta PF3D7_1104400 Thioredoxin domain-containing protein PF3D7_1439900 Triose phosphate isomerase PF3D7_1033900 Ubiquitin-conjugating enzyme PF3D7_1113300 UDP-galactose transporter PF3D7_0934500 V-type proton ATPase subunit E, putative PF3D7_0309800 YTH domain-containing protein PF3D7_1009400 Zinc finger protein, putative Next, we aimed to identify...”
- DB-AT: a 2015 update to the Full-parasites database brings a multitude of new transcriptomic data for apicomplexan parasites
Jąkalski, Nucleic acids research 2015 - “...be selected from below the genome browser. The screen shot shows a case of the PF3D7_1439900 gene. Positions indicated in orange, purple and red boxes are links to the results of single cell analysisIndonesian clinical samples and Comparative view, respectively. Toggling the Browse to Info button...”
- “...updated database, Figure 1 exemplifies the case of a Pf gene annotated as triosephosphate isomerase (PF3D7_1439900), which plays an important role in metabolic pathway of Pf . Particularly, diverse expression levels were observed for this gene both among 116 Indonesian clinical samples and in vitro cultured...”
- Interaction of Silver Nanoparticles with Triosephosphate Isomerase from Human and Malarial Parasite (Plasmodium falciparum): A Comparative Study.
De, Journal of biomedical nanotechnology 2015 (PubMed)- GeneRIF: Polyvinylpyrrolidone stabilised silver nanoparticles (60 nM; 2-6 nm diameter) selectively inhibited PfTIM (triose phosphate isomerase) with a 7-fold decrease in enzyme catalytic efficiency (K(cat)/K(m)) over hTIM.
- Exploring Drug Targets in Isoprenoid Biosynthetic Pathway for Plasmodium falciparum
Qidwai, Biochemistry research international 2014 - “...13 Ferredoxin, putative 194 2 0 PF3D7_1337200 MAL13P1.186 13 1-Deoxy-D-xylulose 5-phosphate synthase 1205 13 2 PF3D7_1439900 PF14_0378 14 Triosephosphate isomerase (TIM) 248 0 0 PF3D7_1467300 PF14_0641 14 1-Deoxy-D-xylulose 5-phosphate reductoisomerase (DOXR) 488 2 2...”
- More
SS1G_11433 triosephosphate isomerase from Sclerotinia sclerotiorum 1980 UF-70
45% identity, 95% coverage
- A "footprint" of plant carbon fixation cycle functions during the development of a heterotrophic fungus
Lyu, Scientific reports 2015 - “...S. sclerotiorum genome. These enzymes are ribose-5-phosphate isomerase (EC: 5.3.1.6, SS1G_08408), triose-phosphate isomerase (EC: 5.3.1.1, SS1G_11433), ribulose-phosphate 3-epimerase (EC: 5.1.3.1, SS1G_01844), transketolase (EC: 2.2.1.1, SS1G_10246), phosphoglycerate kinase (EC: 2.7.2.3, SS1G_01105), fructose-bisphosphate aldolase (EC: 4.1.2.13, SS1G_06561 and SS1G_06400), fructose-bisphosphatase or sedoheptulose-bisphosphatase (EC: 3.1.3.11 or EC: 3.1.3.37, SS1G_11369)...”
- “...4.1.1.49 phosphoenolpyruvate carboxykinase (ATP) SS1G_01844 AT3G01850 (6E-60), AT1G63290 (2E-56), AT5G61410 (5E-42) EC: 5.1.3.1 ribulose-phosphate 3-epimerase SS1G_11433 AT3G55440 (1E-78), AT2G21170 (6E-71) EC: 5.3.1.1 triose-phosphate isomerase SS1G_08408 AT1G71100 (1E-19), AT2G01290 (4E-19) AT3G04790 (3E-15) EC: 5.3.1.6 ribose-5-phosphate isomerase SS1G_08975 AT1G53240 (4E-88), AT2G22780 (3E-84), AT3G47520 (4E-84), AT3G15020 (4E-82), AT5G09660 (3E-74)...”
PITG_16048 triosephosphate isomerase from Phytophthora infestans T30-4
43% identity, 89% coverage
- Switchable Nitroproteome States of Phytophthora infestans Biology and Pathobiology
Izbiańska, Frontiers in microbiology 2019 - “...S37 Crinkler (CRN) family protein 28 PITG_23273 Host-translocated effectors / pathogenesis S38 Triosephosphate isomerase 122 PITG_16048 Carbohydrate metabolism / energy metabolism S39 Putative uncharacterized protein 77 PITG_12486 tRNA processing / nucleobase-containing compound metabolism S40 Putative uncharacterized protein 78 PITG_00160 Signal transduction S41 Crinkler (CRN) family protein...”
Q9M4S8 Triosephosphate isomerase, chloroplastic from Fragaria ananassa
40% identity, 78% coverage
- Comparative proteomics analysis of proteins expressed in the I-1 and I-2 internodes of strawberry stolons
Fang, Proteome science 2011 - “...chain P28439 magnesium ion binding Pelargonium hortorum 53.3/6.3 23.7/7.5 62 32 13/104 69 Triosephosphate isomerase Q9M4S8 triose-phosphate isomerase activity Fragaria ananassa 33.7/7.6 30.0/5.1 152 55 19/112 72 Triosephosphate isomerase Q9M4S8 triose-phosphate isomerase activity Fragaria ananassa 33.7/7.6 31.3/5.6 126 59 16/77 126 Oxygen-evolving enhancer protein 1 P26320...”
- “...Q43157 ribulose-phosphate 3-epimerase activity Spinacia oleracea 30.6/8.2 27.2/7.9 58 31 6/51 82 Triosephosphate isomerase, chloroplastic Q9M4S8 triose-phosphate isomerase activity Fragaria ananassa 33.7/7.6 31.5/5.2 154 51 16/71 90 Oxygen-evolving enhancer protein 1, chloroplastic P26320 calcium ion binding Solanum tuberosum 35.6/5.8 34.5/4.7 98 31 10/48 103 Coproporphyrinogen-III oxidase,...”
- Benzothiadiazole affects the leaf proteome in arctic bramble (Rubus arcticus).
Hukkanen, Molecular plant pathology 2008 (no snippet)
PAS_chr3_0951 Triose phosphate isomerase, abundant glycolytic enzyme from Komagataella phaffii GS115
41% identity, 98% coverage
- Improving Methanol Utilization by Reducing Alcohol Oxidase Activity and Adding Co-Substrate of Sodium Citrate in Pichia pastoris
Liu, Journal of fungi (Basel, Switzerland) 2023 - “...DAS2, dihydroxyacetone synthase 2), PAS_chr1-1_0072 (encoding Fba, fructose 1,6-bisphosphate aldolase), PAS_chr3_0868 (encoding Fbp, fructose 1,6-bisphosphate), PAS_chr3_0951 (encoding Tpi, triose phosphate isomerase), and PAS_chr4_0212 (encoding Rpi, ribose-5-phosphate ketol-isomerase), were all upregulated. At the same time, genes involved in the pentose phosphate pathway (PPP), including PAS_chr3_0277 (encoding Gnd,...”
- “...cell growth in a methanol-minimal medium. Furthermore, most of the genes involved in EMP, including PAS_chr3_0951 (encoding Tpi, triose phosphate isomerase), PAS_chr2-1_0437 (encoding GAPDH, glyceraldehyde-3-phosphate dehydrogenase), PAS_chr1-4_0292 (encoding Pgk, 3-phosphoglycerate kinase), PAS_chr3_0826 (encoding gpmA, tetrameric phosphoglycerate mutase), PAS_chr3_0082 (encoding ENO, enolase I), PAS_chr2-2_0294 (encoding AceE, E1...”
XP_002785920 triose-phosphate isomerase 1, putative from Perkinsus marinus ATCC 50983
41% identity, 98% coverage
NMA0570 putative triosephosphate isomerase from Neisseria meningitidis Z2491
39% identity, 98% coverage
TGME49_025930 triose-phosphate isomerase TPI-I from Toxoplasma gondii ME49
39% identity, 98% coverage
For advice on how to use these tools together, see
Interactive tools for functional annotation of bacterial genomes.
The PaperBLAST database links 789,361 different protein sequences to 1,256,019 scientific articles. Searches against EuropePMC were last performed on January 10 2025.
PaperBLAST builds a database of protein sequences that are linked
to scientific articles. These links come from automated text searches
against the articles in EuropePMC
and from manually-curated information from GeneRIF, UniProtKB/Swiss-Prot,
BRENDA,
CAZy (as made available by dbCAN),
BioLiP,
CharProtDB,
MetaCyc,
EcoCyc,
TCDB,
REBASE,
the Fitness Browser,
and a subset of the European Nucleotide Archive with the /experiment tag.
Given this database and a protein sequence query,
PaperBLAST uses protein-protein BLAST
to find similar sequences with E < 0.001.
To build the database, we query EuropePMC with locus tags, with RefSeq protein
identifiers, and with UniProt
accessions. We obtain the locus tags from RefSeq or from MicrobesOnline. We use
queries of the form "locus_tag AND genus_name" to try to ensure that
the paper is actually discussing that gene. Because EuropePMC indexes
most recent biomedical papers, even if they are not open access, some
of the links may be to papers that you cannot read or that our
computers cannot read. We query each of these identifiers that
appears in the open access part of EuropePMC, as well as every locus
tag that appears in the 500 most-referenced genomes, so that a gene
may appear in the PaperBLAST results even though none of the papers
that mention it are open access. We also incorporate text-mined links
from EuropePMC that link open access articles to UniProt or RefSeq
identifiers. (This yields some additional links because EuropePMC
uses different heuristics for their text mining than we do.)
For every article that mentions a locus tag, a RefSeq protein
identifier, or a UniProt accession, we try to select one or two
snippets of text that refer to the protein. If we cannot get access to
the full text, we try to select a snippet from the abstract, but
unfortunately, unique identifiers such as locus tags are rarely
provided in abstracts.
PaperBLAST also incorporates manually-curated protein functions:
- Proteins from NCBI's RefSeq are included if a
GeneRIF
entry links the gene to an article in
PubMed®.
GeneRIF also provides a short summary of the article's claim about the
protein, which is shown instead of a snippet.
- Proteins from Swiss-Prot (the curated part of UniProt)
are included if the curators
identified experimental evidence for the protein's function (evidence
code ECO:0000269). For these proteins, the fields of the Swiss-Prot entry that
describe the protein's function are shown (with bold headings).
- Proteins from BRENDA,
a curated database of enzymes, are included if they are linked to a paper in PubMed
and their full sequence is known.
- Every protein from the non-redundant subset of
BioLiP,
a database
of ligand-binding sites and catalytic residues in protein structures, is included. Since BioLiP itself
does not include descriptions of the proteins, those are taken from the
Protein Data Bank.
Descriptions from PDB rely on the original submitter of the
structure and cannot be updated by others, so they may be less reliable.
(For SitesBLAST and Sites on a Tree, we use a larger subset of BioLiP so that every
ligand is represented among a group of structures with similar sequences, but for
PaperBLAST, we use the non-redundant set provided by BioLiP.)
- Every protein from EcoCyc, a curated
database of the proteins in Escherichia coli K-12, is included, regardless
of whether they are characterized or not.
- Proteins from the MetaCyc metabolic pathway database
are included if they are linked to a paper in PubMed and their full sequence is known.
- Proteins from the Transport Classification Database (TCDB)
are included if they have known substrate(s), have reference(s),
and are not described as uncharacterized or putative.
(Some of the references are not visible on the PaperBLAST web site.)
- Every protein from CharProtDB,
a database of experimentally characterized protein annotations, is included.
- Proteins from the CAZy database of carbohydrate-active enzymes
are included if they are associated with an Enzyme Classification number.
Even though CAZy does not provide links from individual protein sequences to papers,
these should all be experimentally-characterized proteins.
- Proteins from the REBASE database
of restriction enzymes are included if they have known specificity.
- Every protein with an evidence-based reannotation (based on mutant phenotypes)
in the Fitness Browser is included.
- Sequence-specific transcription factors (including sigma factors and DNA-binding response regulators)
with experimentally-determined DNA binding sites from the
PRODORIC database of gene regulation in prokaryotes.
- Putative transcription factors from RegPrecise
that have manually-curated predictions for their binding sites. These predictions are based on
conserved putative regulatory sites across genomes that contain similar transcription factors,
so PaperBLAST clusters the TFs at 70% identity and retains just one member of each cluster.
- Coding sequence (CDS) features from the
European Nucleotide Archive (ENA)
are included if the /experiment tag is set (implying that there is experimental evidence for the annotation),
the nucleotide entry links to paper(s) in PubMed,
and the nucleotide entry is from the STD data class
(implying that these are targeted annotated sequences, not from shotgun sequencing).
Also, to filter out genes whose transcription or translation was detected, but whose function
was not studied, nucleotide entries or papers with more than 25 such proteins are excluded.
Descriptions from ENA rely on the original submitter of the
sequence and cannot be updated by others, so they may be less reliable.
Except for GeneRIF and ENA,
the curated entries include a short curated
description of the protein's function.
For entries from BioLiP, the protein's function may not be known beyond binding to the ligand.
Many of these entries also link to articles in PubMed.
For more information see the
PaperBLAST paper (mSystems 2017)
or the code.
You can download PaperBLAST's database here.
Changes to PaperBLAST since the paper was written:
- November 2023: incorporated PRODORIC and RegPrecise. Many PRODORIC entries were not linked to a protein sequence (no UniProt identifier), so we added this information.
- February 2023: BioLiP changed their download format. PaperBLAST now includes their non-redundant subset. SitesBLAST and Sites on a Tree use a larger non-redundant subset that ensures that every ligand is represented within each cluster. This should ensure that every binding site is represented.
- June 2022: incorporated some coding sequences from ENA with the /experiment tag.
- March 2022: incorporated BioLiP.
- April 2020: incorporated TCDB.
- April 2019: EuropePMC now returns table entries in their search results. This has expanded PaperBLAST's database, but most of the new entries are of low relevance, and the resulting snippets are often just lists of locus tags with annotations.
- February 2018: the alignment page reports the conservation of the hit's functional sites (if available from from Swiss-Prot or UniProt)
- January 2018: incorporated BRENDA.
- December 2017: incorporated MetaCyc, CharProtDB, CAZy, REBASE, and the reannotations from the Fitness Browser.
- September 2017: EuropePMC no longer returns some table entries in their search results. This has shrunk PaperBLAST's database, but has also reduced the number of low-relevance hits.
Many of these changes are described in Interactive tools for functional annotation of bacterial genomes.
PaperBLAST cannot provide snippets for many of the papers that are
published in non-open-access journals. This limitation applies even if
the paper is marked as "free" on the publisher's web site and is
available in PubmedCentral or EuropePMC. If a journal that you publish
in is marked as "secret," please consider publishing elsewhere.
Many important articles are missing from PaperBLAST, either because
the article's full text is not in EuropePMC (as for many older
articles), or because the paper does not mention a protein identifier such as a locus tag, or because of PaperBLAST's heuristics. If you notice an
article that characterizes a protein's function but is missing from
PaperBLAST, please notify the curators at UniProt
or add an entry to GeneRIF.
Entries in either of these databases will eventually be incorporated
into PaperBLAST. Note that to add an entry to UniProt, you will need
to find the UniProt identifier for the protein. If the protein is not
already in UniProt, you can ask them to create an entry. To add an
entry to GeneRIF, you will need an NCBI Gene identifier, but
unfortunately many prokaryotic proteins in RefSeq do not have
corresponding Gene identifers.
References
PaperBLAST: Text-mining papers for information about homologs.
M. N. Price and A. P. Arkin (2017). mSystems, 10.1128/mSystems.00039-17.
Europe PMC in 2017.
M. Levchenko et al (2017). Nucleic Acids Research, 10.1093/nar/gkx1005.
Gene indexing: characterization and analysis of NLM's GeneRIFs.
J. A. Mitchell et al (2003). AMIA Annu Symp Proc 2003:460-464.
UniProt: the universal protein knowledgebase.
The UniProt Consortium (2016). Nucleic Acids Research, 10.1093/nar/gkw1099.
BRENDA in 2017: new perspectives and new tools in BRENDA.
S. Placzek et al (2017). Nucleic Acids Research, 10.1093/nar/gkw952.
The EcoCyc database: reflecting new knowledge about Escherichia coli K-12.
I. M. Keeseler et al (2016). Nucleic Acids Research, 10.1093/nar/gkw1003.
The MetaCyc database of metabolic pathways and enzymes.
R. Caspi et al (2018). Nucleic Acids Research, 10.1093/nar/gkx935.
CharProtDB: a database of experimentally characterized protein annotations.
R. Madupu et al (2012). Nucleic Acids Research, 10.1093/nar/gkr1133.
The carbohydrate-active enzymes database (CAZy) in 2013.
V. Lombard et al (2014). Nucleic Acids Research, 10.1093/nar/gkt1178.
The Transporter Classification Database (TCDB): recent advances
M. H. Saier, Jr. et al (2016). Nucleic Acids Research, 10.1093/nar/gkv1103.
REBASE - a database for DNA restriction and modification: enzymes, genes and genomes.
R. J. Roberts et al (2015). Nucleic Acids Research, 10.1093/nar/gku1046.
Deep annotation of protein function across diverse bacteria from mutant phenotypes.
M. N. Price et al (2016). bioRxiv, 10.1101/072470.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory