PaperBLAST
PaperBLAST Hits for CharProtDB::CH_002452 phosphoglucomutase; EC 5.4.2.2 (Escherichia coli K12) (546 a.a., MAIHNRAGQP...)
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>CharProtDB::CH_002452 phosphoglucomutase; EC 5.4.2.2 (Escherichia coli K12)
MAIHNRAGQPAQQSDLINVAQLTAQYYVLKPEAGNAEHAVKFGTSGHRGSAARHSFNEPH
ILAIAQAIAEERAKNGITGPCYVGKDTHALSEPAFISVLEVLAANGVDVIVQENNGFTPT
PAVSNAILVHNKKGGPLADGIVITPSHNPPEDGGIKYNPPNGGPADTNVTKVVEDRANAL
LADGLKGVKRISLDEAMASGHVKEQDLVQPFVEGLADIVDMAAIQKAGLTLGVDPLGGSG
IEYWKRIGEYYNLNLTIVNDQVDQTFRFMHLDKDGAIRMDCSSECAMAGLLALRDKFDLA
FANDPDYDRHGIVTPAGLMNPNHYLAVAINYLFQHRPQWGKDVAVGKTLVSSAMIDRVVN
DLGRKLVEVPVGFKWFVDGLFDGSFGFGGEESAGASFLRFDGTPWSTDKDGIIMCLLAAE
ITAVTGKNPQEHYNELAKRFGAPSYNRLQAAATSAQKAALSKLSPEMVSASTLAGDPITA
RLTAAPGNGASIGGLKVMTDNGWFAARPSGTEDAYKIYCESFLGEEHRKQIEKEAVEIVS
EVLKNA
Running BLASTp...
Found 250 similar proteins in the literature:
UTI89_C0693 phosphoglucomutase from Escherichia coli UTI89
100% identity, 97% coverage
EC958_0806 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) from Escherichia coli O25b:H4-ST131
100% identity, 100% coverage
- The serum resistome of a globally disseminated multidrug resistant uropathogenic Escherichia coli clone
Phan, PLoS genetics 2013 - “...the greatest difference between the test and control samples (logFC of 10), followed by pgm (EC958_0806), encoding phosphoglucomutase. Four hypothetical proteins were also identified, two of which (EC958_0460 and EC958_0461) were further characterized in this study (see below). 10.1371/journal.pgen.1003834.t002 Table 2 Genes required for serum resistance...”
- “...1 WT WT WT KG EC958_0785 nagA b0677 N-acetylglucosamine-6-phosphate deacetylase 3 X 0.063 WT G EC958_0806 pgm b0688 Phosphoglucomutase 4 X 0.016 WT G EC958_0856 tolQ b0737 membrane spanning protein in Tol-Pal cell envelope complex 3 WT 0.031 WT U EC958_0858 tolA b0739 membrane anchored protein...”
Blu / b0688 phosphoglucomutase (EC 5.4.2.2) from Escherichia coli K-12 substr. MG1655 (see 11 papers)
pgm / P36938 phosphoglucomutase (EC 5.4.2.2) from Escherichia coli (strain K12) (see 11 papers)
PGM_ECOLI / P36938 Phosphoglucomutase; PGM; Glucose phosphomutase; EC 5.4.2.2 from Escherichia coli (strain K12) (see 2 papers)
pgm / GB|ABB65241.1 phosphoglucomutase; EC 5.4.2.2 from Escherichia coli K12 (see 6 papers)
b0688 phosphoglucomutase from Escherichia coli str. K-12 substr. MG1655
100% identity, 100% coverage
- function: This enzyme participates in both the breakdown and synthesis of glucose.
catalytic activity: alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate (RHEA:23536)
cofactor: Mg(2+) (Binds 1 Mg(2+) ion per subunit.) - Biodistribution of 89Zr-DFO-labeled avian pathogenic Escherichia coli outer membrane vesicles by PET imaging in chickens
Li, Poultry science 2023 - “...113 P0AGJ9 SYY Translation, ribosomal structure and biogenesis Cytoplasm 114 P0AGB6 RPOE Transcription Cytoplasm 115 P36938 PGM Carbohydrate transport and metabolism Cytoplasm 116 P0A705 IF2 Translation, ribosomal structure and biogenesis Cytoplasm 117 P0AES6 GYRB Replication, recombination and repair Cytoplasm 118 P0A6U3 MNMG Cell cycle control, cell...”
- Exposure of E. coli to DNA-Methylating Agents Impairs Biofilm Formation and Invasion of Eukaryotic Cells via Down Regulation of the N-Acetylneuraminate Lyase NanA
Di, Frontiers in microbiology 2016 - “...gpmA P62707 1.12 2062 0.0069 Pyruvate kinase I pykF P0AD61 +1.24 2169 0.0053 Phosphoglucomutase pgm P36938 AMINOACYL-tRNA BIOSYNTHESIS 1.69 3047 0.0044 Phenylalanine tRNA synthetase, alpha subunit pheS P08312 1.27 1307 0.0004 ThreoninetRNA ligase thrS P0A8M3 1.19 3031 0.0071 tRNA-dihydrouridine synthase A dusA P32695 1.17 2425 0.005...”
- Inactivation of the phosphoglucomutase gene pgm in Corynebacterium glutamicum affects cell shape and glycogen metabolism
Seibold, Bioscience reports 2013 - “...( pmmB ), Q8NSD0 cg0854 ( manB ), Q8NMN0 cg2800 ( pgm ); E. coli P36938 b0688 ( pgm ); B. subtilis P18159 bsu09310 ( pgcA ); Pseudomonas aeruginosa P26276 pa5322 ( algC ). RESULTS Pgm activity and glycogen content in C. glutamicum As Pgm probably...”
- Gene cluster involved in the biosynthesis of griseobactin, a catechol-peptide siderophore of Streptomyces sp. ATCC 700974
Patzer, Journal of bacteriology 2010 - “...of two Identity, similarity (%) Pgm (555)/E. coli (P36938) 58, 72 DhbB (312; C-terminal 88 amino acids)/B. subtilis (P45743) EntB (285; C-terminal 78 amino...”
- Requirement for phosphoglucomutase in exopolysaccharide biosynthesis in glucose- and lactose-utilizing Streptococcus thermophilus
Levander, Applied and environmental microbiology 2001 - “...Q44417; Pgm A. xylinum, P38569; Pgm E. coli, P36938; YhxB, P18159; Pgm S. pneumoniae, Q9RP94. Downloaded from http://aem.asm.org/ on February 19, 2017 by...”
- Novel genes associated with enhanced motility of Escherichia coli ST131
Kakkanat, PloS one 2017 - “...b3009 9.17 general envelope maintenance protein S EC958_4909 ydfD b1576 9.15 - EC958_1929 ydiV # b0688 8.88 anti-FlhD 4 C 2 factor T EC958_2115 yecG b1895 8.82 universal stress protein T EC958_1122 ihfB # b0912 8.78 integration host factor (IHF) beta subunit L EC958_3259 papX #...”
- Metabolic shift of Escherichia coli under salt stress in the presence of glycine betaine
Metris, Applied and environmental microbiology 2014 - “...b1732 b1732 b2206 b4238 b0957 b0957 b0957 b0565 b0565 b1243 b0903 b0688 b2502 b0243 b2679 b0636 b3296 b4200 b2533 b1261 b1264 b1263 b4058 4.5 5 2 2 4.5 4.5 4.5...”
- The serum resistome of a globally disseminated multidrug resistant uropathogenic Escherichia coli clone
Phan, PLoS genetics 2013 - “...WT WT KG EC958_0785 nagA b0677 N-acetylglucosamine-6-phosphate deacetylase 3 X 0.063 WT G EC958_0806 pgm b0688 Phosphoglucomutase 4 X 0.016 WT G EC958_0856 tolQ b0737 membrane spanning protein in Tol-Pal cell envelope complex 3 WT 0.031 WT U EC958_0858 tolA b0739 membrane anchored protein in Tol-Pal...”
- Inactivation of the phosphoglucomutase gene pgm in Corynebacterium glutamicum affects cell shape and glycogen metabolism
Seibold, Bioscience reports 2013 - “...pmmB ), Q8NSD0 cg0854 ( manB ), Q8NMN0 cg2800 ( pgm ); E. coli P36938 b0688 ( pgm ); B. subtilis P18159 bsu09310 ( pgcA ); Pseudomonas aeruginosa P26276 pa5322 ( algC ). RESULTS Pgm activity and glycogen content in C. glutamicum As Pgm probably acts...”
- Role of SeqA and Dam in Escherichia coli gene expression: a global/microarray analysis
Løbner-Olesen, Proceedings of the National Academy of Sciences of the United States of America 2003 - “...aroKcatwt seqA pgm aroK aroB damX dam rpe gph trpS b0687 b0688 b3390 b3389 b3388 b3387 b3386 b3385 b3384 0.06* 0.36 1.1 1.1 1.1 1.1 1.0 1.2 0.99 48 1.3 0.90...”
c0775 Phosphoglucomutase from Escherichia coli CFT073
100% identity, 97% coverage
Z0837 phosphoglucomutase from Escherichia coli O157:H7 EDL933
99% identity, 100% coverage
A0A0H3NJ17 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Salmonella enterica subsp. enterica serovar Typhimurium (see paper)
Q8ZQW9 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Salmonella enterica subsp. enterica serovar Typhimurium (see paper)
NP_459683 phosphoglucomutase from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
STM0698 phosphoglucomutase from Salmonella typhimurium LT2
STM14_0815 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) from Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S
98% identity, 100% coverage
- Data on the phosphorylation state of the catalytic serine of enzymes in the α-D-phosphohexomutase superfamily
Lee, Data in brief 2017 - “...52436.66 FtPNGM Q5NII8 50922.58 51002.58 50922.80 51003.06 BaPNGM b Q81VN7 50978.90 51058.90 50979.70 51059.44 StPGM Q8ZQW9 60827.49 60907.49 60828.97 60905.95 hPGM1 P36871 64115.95 64195.95 64116.10 64196.52 a Based on amino acid sequence of recombinantly expressed proteins, including affinity tags. b Calculated MW of BaPNGM corrected for...”
- Biology, Mechanism, and Structure of Enzymes in the α-d-Phosphohexomutase Superfamily
Stiers, Advances in protein chemistry and structural biology 2017 - “...No resi. Resolution () * P-Ser Divalent metal ion Ligand Oligomer? PGM S. typhimurium bacterial Q8ZQW9 2FUV, 3NA5, 3OLP 546 1.70 N Mg dimer T. thermophilus bacterial Q5SLE0 2Z0F 524 2.52 N No (pH 5.4) dimer L. minor bacterial Q4QCF1 4QG5 589 3.50 Mg H. sapiens...”
- Crystal structure of a bacterial phosphoglucomutase, an enzyme involved in the virulence of multiple human pathogens.
Mehra-Chaudhary, Proteins 2011 - GeneRIF: The crystal structure of the enzyme phosphoglucomutase from Salmonella typhimurium (StPGM) is reported at 1.7 A resolution.
- The enzyme phosphoglucomutase (Pgm) is required by Salmonella enterica serovar Typhimurium for O-antigen production, resistance to antimicrobial peptides and in vivo fitness.
Paterson, Microbiology (Reading, England) 2009 (PubMed)- GeneRIF: Although pgm deletion mutants in other pathogens have potential as live attenuated vaccine strains, Salmonella typhimurium SL1344 pgm deletion mutant was not sufficiently attenuated for such use.
- Inorganic Polyphosphate Is Essential for Salmonella Typhimurium Virulence and Survival in Dictyostelium discoideum
Varas, Frontiers in cellular and infection microbiology 2018 - “...STM14_0693 STM0595 entC Isochorismate synthase STM14_0743 STM0636 ybeD Hypothetical protein STM14_0806 STM0691 Tricarballylate dehydrogenase STM14_0815 STM0698 pgm Phosphoglucomutase STM14_1013 STM0863 dacC D-alanyl-D-alanine carboxypeptidase fraction C STM14_1056 STM0939 ybjD Hypothetical protein STM14_1106 STM0978 aroA 3-phosphoshikimate 1-carboxyvinyltransferase STM14_1259 STM1109 Putative periplasmic protein STM14_1309 STM1143 csgB Curlin minor subunit...”
- Genome wide evolutionary analyses reveal serotype specific patterns of positive selection in selected Salmonella serotypes
Soyer, BMC evolutionary biology 2009 - “...3-hydroxyisobutyrate dehydrogenase 840 Ch# (0.0138) - STM3680 aldB Aldehyde dehydrogenase B 1536 Pty# (0.020) - STM0698 pgm Phosphoglucomutase, alpha-D-glucose phosphate-specific 1638 Ty# (0.0157) - STM3515 malt MalT regulatory protein 2703 Ty# (0.0198) 801 STM4187 iclR Acetate operon repressor 819 Ty# (0.0693) - STM0401 malZ Glycosyl hydrolase,...”
- Inorganic Polyphosphate Is Essential for Salmonella Typhimurium Virulence and Survival in Dictyostelium discoideum
Varas, Frontiers in cellular and infection microbiology 2018 - “...transposase STM14_0693 STM0595 entC Isochorismate synthase STM14_0743 STM0636 ybeD Hypothetical protein STM14_0806 STM0691 Tricarballylate dehydrogenase STM14_0815 STM0698 pgm Phosphoglucomutase STM14_1013 STM0863 dacC D-alanyl-D-alanine carboxypeptidase fraction C STM14_1056 STM0939 ybjD Hypothetical protein STM14_1106 STM0978 aroA 3-phosphoshikimate 1-carboxyvinyltransferase STM14_1259 STM1109 Putative periplasmic protein STM14_1309 STM1143 csgB Curlin minor...”
2fuvA / Q8ZQW9 Phosphoglucomutase from salmonella typhimurium.
98% identity, 100% coverage
- Ligand: magnesium ion (2fuvA)
KP1_1664 phosphoglucomutase from Klebsiella pneumoniae NTUH-K2044
96% identity, 99% coverage
- The Capsule Regulatory Network of Klebsiella pneumoniae Defined by density-TraDISort
Dorman, mBio 2018 - “...RfaH 1.00 KP1_0199 VK055_3141 seqA Replication initiation regulator SeqA 0.99 KP1_1663 VK055_1821 pgm Phosphoglucomutase 1.00 KP1_1664 VK055_1820 gnd 6-Phosphogluconate dehydrogenase 0.69 KP1_3704 VK055_5026 wcaJ Colanic acid biosynthsis UDP-glucose lipid carrier transferase WcaJ 0.20 KP1_3705 VK055_5025 wza Polysaccharide export protein 0.98 KP1_3720 VK055_5015 wzi Outer membrane protein...”
A6T6D3 Phosphoglucomutase from Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
96% identity, 100% coverage
VK055_1820 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) from Klebsiella pneumoniae subsp. pneumoniae
96% identity, 100% coverage
- The Capsule Regulatory Network of Klebsiella pneumoniae Defined by density-TraDISort
Dorman, mBio 2018 - “...1.00 KP1_0199 VK055_3141 seqA Replication initiation regulator SeqA 0.99 KP1_1663 VK055_1821 pgm Phosphoglucomutase 1.00 KP1_1664 VK055_1820 gnd 6-Phosphogluconate dehydrogenase 0.69 KP1_3704 VK055_5026 wcaJ Colanic acid biosynthsis UDP-glucose lipid carrier transferase WcaJ 0.20 KP1_3705 VK055_5025 wza Polysaccharide export protein 0.98 KP1_3720 VK055_5015 wzi Outer membrane protein 0.99...”
t2177 phosphoglucomutase from Salmonella enterica subsp. enterica serovar Typhi Ty2
98% identity, 100% coverage
ENT638_RS06320 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) from Enterobacter sp. 638
94% identity, 100% coverage
PMPD1_1435 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) from Paramixta manurensis
89% identity, 100% coverage
H3RAQ5 Phosphoglucomutase from Pantoea stewartii subsp. stewartii DC283
88% identity, 100% coverage
YPO2686 phosphoglucomutase from Yersinia pestis CO92
83% identity, 100% coverage
y1258 phosphoglucomutase from Yersinia pestis KIM
83% identity, 97% coverage
YPTB2923 phosphoglucomutase from Yersinia pseudotuberculosis IP 32953
82% identity, 97% coverage
VP0839 phosphoglucomutase from Vibrio parahaemolyticus RIMD 2210633
71% identity, 100% coverage
N646_2991 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) from Vibrio alginolyticus NBRC 15630 = ATCC 17749
71% identity, 100% coverage
A0A0H5W931 Phosphoglucomutase from Vibrio cholerae
70% identity, 100% coverage
FORC16_0769 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) from Vibrio vulnificus
70% identity, 99% coverage
D9T18_08400 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) from Pseudoalteromonas agarivorans
62% identity, 99% coverage
A0QUA6 Phosphoglucomutase, alpha-D-glucose phosphate-specific from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)
MSMEG_2136 phosphoglucomutase, alpha-D-glucose phosphate-specific from Mycobacterium smegmatis str. MC2 155
61% identity, 99% coverage
Q9L117 Phosphoglucomutase from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
SCO7443 phosphoglucomutase from Streptomyces coelicolor A3(2)
61% identity, 98% coverage
- Comparative proteomic analysis of Streptomyces lividans Wild-Type and ppk mutant strains reveals the importance of storage lipids for antibiotic biosynthesis
Le, Applied and environmental microbiology 2013 - “...135 140 28 40 Up Up 4 3 SCO7443 SCO3649 SCO1945 Q9L117 Q9X8R6 Q9Z520 57/5.3 37/5.4 28/5.2 165 107 162 36 35 34 Down Down Down 4 3 3 Dihydrolipoamide...”
- Pathway Engineering of Anthracyclines: Blazing Trails in Natural Product Glycodiversification
Brown, The Journal of organic chemistry 2020 - “...promising technique to funnel carbon from central metabolism towards polyketide biosynthesis. Overexpression of phosphoglucomutase (Pgm, sco7443 ) and the acetyl-CoA carboxylase complex (ACCase, ovmGIH ) increased precursor substrate levels of glucose-1-phosphate and malonyl-CoA, respectively, which ubiquitously enhanced production titers of 2 , 3 , 5 ,...”
- “...production of the anticancer polyketide, mithramycin by overexpressing Pgm and ACCase 35 . Overexpression of sco7443 resulted in higher titers of mithramycin early in the logarithmic growth phase of the engineered strain (e.g. 180% after 3 days and 62% after 4 days) before leveling off to...”
- Disruption of the GDP-mannose synthesis pathway in Streptomyces coelicolor results in antibiotic hyper-susceptible phenotypes
Howlett, Microbiology (Reading, England) 2018 - “...when the wild-type E. coli manB was introduced whilst the S. coelicolor pgm gene ( sco7443 ) failed to complement. Thus PMM activity was shown to be solely responsible for an increase in chloramphenicol sensitivity and actinorhodin production in S. coelicolor M145. If SCO3028 is the...”
- “...may be sufficient PMM activity from other closely related enzymes (such as other PGM paralogues; sco7443 or sco4916 a possible alternative phosphomannomutase) to allow growth. The more severe phenotypes of the GMP depletion mutant and the manB mutant also suggest that GDP-mannose could be located at...”
- Quantitative Proteome and Phosphoproteome Analyses of <i>Streptomyces coelicolor</i> Reveal Proteins and Phosphoproteins Modulating Differentiation and Secondary Metabolism
Rioseras, Molecular & cellular proteomics : MCP 2018 - “...n.s. 2.2 n.s. 4.5 Folate biosynthesis SCO3401 SAPFAQGPSDPTVQPVPASVIEQVDAADT pT LSNPK n.s. -1.5 n.s. 0.3 Glycoslisis SCO7443 TSGLADGVVVTP pS HNPPADGGFK n.s. 1.4 n.s. 2.7 Unknown SCO2668 AGDIDGA pT AK n.s. 1.1 n.s. 2.1 SCO2668 VEEADEMTLETR pSpT K pT VR n.s. 1.9 n.s. 3.8 SCO2668 AVQLAGVSGNAD pT AK...”
- Comparative proteomic analysis of Streptomyces lividans Wild-Type and ppk mutant strains reveals the importance of storage lipids for antibiotic biosynthesis
Le, Applied and environmental microbiology 2013 - “...One of these proteins is a phosphoglucomutase (SCO7443) that catalyzes the conversion of glucose-1-phosphate (likely originating from glycogen degradation) into...”
- “...Q9F2Q3 Q9Z518 46/4.5 36/5.2 135 140 28 40 Up Up 4 3 SCO7443 SCO3649 SCO1945 Q9L117 Q9X8R6 Q9Z520 57/5.3 37/5.4 28/5.2 165 107 162 36 35 34 Down Down Down 4 3 3...”
- Engineering of primary carbohydrate metabolism for increased production of actinorhodin in Streptomyces coelicolor
Ryu, Applied and environmental microbiology 2006 - “...(Act), while the function of Pgm encoded by SCO7443 is not clearly understood. The pgm-deleted mutant unexpectedly produced abundant glycogen but was impaired...”
- “...the hygromycin resistance cassette in pIJ774, and pgm (SCO7443) was disrupted using the apramycin resistance cassette in pIJ773 (9). Resistance cassettes were...”
- Lactose-over-glucose preference in Bifidobacterium longum NCC2705: glcP, encoding a glucose transporter, is subject to lactose repression
Parche, Journal of bacteriology 2006 - “...57% protein identity to Pgm of S. coelicolor (SCO7443) is located 85 nucleotides downstream of glcP, followed by a potential transcriptional terminator. A...”
Q8NMN0 Phosphoglucomutase from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / BCRC 11384 / CCUG 27702 / LMG 3730 / NBRC 12168 / NCIMB 10025 / NRRL B-2784 / 534)
cg2800 phosphoglucomutase from Corynebacterium glutamicum ATCC 13032
62% identity, 97% coverage
- Inactivation of the phosphoglucomutase gene pgm in Corynebacterium glutamicum affects cell shape and glycogen metabolism
Seibold, Bioscience reports 2013 - “...and/or phosphomannomutase are C. glutamicum Q6M788 cg0788 ( pmmB ), Q8NSD0 cg0854 ( manB ), Q8NMN0 cg2800 ( pgm ); E. coli P36938 b0688 ( pgm ); B. subtilis P18159 bsu09310 ( pgcA ); Pseudomonas aeruginosa P26276 pa5322 ( algC ). RESULTS Pgm activity and glycogen...”
- Metabolic Engineering of Corynebacterium glutamicum for the Production of Flavonoids and Stilbenoids
Chu, Molecules (Basel, Switzerland) 2024 - “...UDP-glucose biosynthesis for UDP-glucose accumulation. However, the supply of UDP-glucose consists of genes pgm ( cg2800 ) and galU1 ( cg1004 ) resulted in a 4.2-fold higher C3G production in engineered C. glutamicum (reaching 31.8 mg/L) [ 20 ]. 6. Future Perspectives and Conclusions Although E....”
- CRISPRi-Library-Guided Target Identification for Engineering Carotenoid Production by Corynebacterium glutamicum
Göttl, Microorganisms 2021 - “...plasmid carrying the pgl (cg1780) sgRNA This work pS_dCas9_ pgm pS_dCas9 plasmid carrying the pgm (cg2800) sgRNA This work pS_dCas9_ ppc pS_dCas9 plasmid carrying the ppc (cg1787) sgRNA This work pS_dCas9_ ppsA pS_dCas9 plasmid carrying the ppsA (cg0644) sgRNA This work pS_dCas9_ pqo pS_dCas9 plasmid carrying...”
- Identifying the Growth Modulon of Corynebacterium glutamicum
Haas, Frontiers in microbiology 2019 - “...cg2932 , which encode glucokinases were also in cluster 1. Interestingly, gpmA (cg0482) and pgm (cg2800) were the only genes encoding enyzmes of the glycolysis that did not amplify expression with increasing growth rates. No regulatory interactions were identified for these two genes. Apparently, their expression...”
- Metabolic engineering of Corynebacterium glutamicum for anthocyanin production
Zha, Microbial cell factories 2018 - “...is to amplify endogenous pathway genes. Previous studies have shown that overexpression of genes pgm (cg2800) and galU1 (cg1004), both essential in the UDP-glucose biosynthesis pathway [ 36 ], increases the level of UDP-glucose for cyanidin glycosylation [ 16 , 37 ]. Therefore, we constructed C....”
- Inactivation of the phosphoglucomutase gene pgm in Corynebacterium glutamicum affects cell shape and glycogen metabolism
Seibold, Bioscience reports 2013 - “...form glc-1-P. We here show that C. glutamicum possesses at least two Pgm isoenzymes, the cg2800 ( pgm ) encoded enzyme contributing most to total Pgm activity. By inactivation of pgm we created C. glutamicum IMpgm showing only about 12% Pgm activity when compared to the...”
- “...in cell extracts of C. glutamicum [ 13 ] and the ORF (open reading frame) cg2800 has been annotated as Pgm gene pgm based on sequence comparisons [ 18 ]. We recently found pgm to be up-regulated in response to phosphate limitation [ 9 ], however,...”
APA386B_513 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) from Acetobacter pasteurianus 386B
59% identity, 97% coverage
ACPL_2870 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) from Actinoplanes sp. SE50/110
60% identity, 100% coverage
SAV_803 phosphoglucomutase from Streptomyces avermitilis MA-4680
59% identity, 97% coverage
- SAV742, a Novel AraC-Family Regulator from Streptomyces avermitilis, Controls Avermectin Biosynthesis, Cell Growth and Development
Sun, Scientific reports 2016 - “...2-oxoglutarate ferredoxin oxidoreductase) and icdA (sav_7214 , encoding a putative isocitrate dehydrogenase); in glycolysis: pgmA (sav_803 , encoding a putative phosphoglucomutase), gap2 (sav_6296 , encoding a putative glyceraldehyde-3-phosphate dehydrogenase) and pykA1 (sav_2825 , encoding a putative pyruvate kinase); in N-acetylglucosamine (GlcNAc) utilization: dasR (sav_3023 , encoding...”
SO2336 phosphoglucomutase, alpha-D-glucose phosphate-specific from Shewanella oneidensis MR-1
58% identity, 99% coverage
PP_3578 phosphoglucomutase, alpha-D-glucose phosphate-specific from Pseudomonas putida KT2440
59% identity, 99% coverage
celB / AAA21561.1 phosphoglucomutase from Komagataeibacter xylinus (see paper)
58% identity, 97% coverage
B0W47_02175 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) from Komagataeibacter nataicola
58% identity, 98% coverage
K3G22_09265 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) from Shewanella putrefaciens
57% identity, 99% coverage
sll0726 phosphoglucomutase from Synechocystis sp. PCC 6803
59% identity, 95% coverage
- Phosphoglucomutase comes into the spotlight
Doello, Journal of experimental botany 2023 - “...the phosphoglucomutases. In Synechocystis , two enzymes are capable of carrying out the phosphoglucomutase reaction: Sll0726 (PGM), which is responsible for 99% of the phosphoglucomutase activity, and Slr1334 (PGM/PMM). Although Slr1334 only has a minor contribution in the interconversion of G1P and G6P, it is able...”
- “...or G6P and fructose-1,6-bisphosphate (F1,6BP) (represented in blue). G1,6BP functions as an activator compound for Sll0726, thus regulating a fundamental reaction for carbon metabolism. For most of the enzymes involved in glycogen synthesis and degradation, Synechocystis harbours two genes encoding two different isoforms that are required...”
- Stress response requires an efficient connection between glycogen and central carbon metabolism by phosphoglucomutases in cyanobacteria
Ortega-Martínez, Journal of experimental botany 2023 - “...to the phosphohexomutase superfamily: sll1758 coding for a predicted protein of the PNGM subgroup; and sll0726 and slr1334 , coding for PGM and PMM/PGM, respectively, both enzymes with phosphoglucomutase activity ( Liu et al. , 2013 ). Recent findings in Synechocystis have highlighted the role of...”
- “...and 5 g ml 1 erythromycin). Generation of mutant strains The PGM strain lacking the sll0726 gene was obtained by transformation of the wild-type (WT) strain with plasmid pGTsll0726::Km, which allows for the deletion of the complete sll0726 ORF. To generate this plasmid, regions upstream and...”
- Site-2 Protease Slr1821 Regulates Carbon/Nitrogen Homeostasis during Ammonium Stress Acclimation in Cyanobacterium Synechocystis sp. PCC 6803
Lin, International journal of molecular sciences 2023 - “...WT. Intriguingly, biosynthesis of another carbon storage polymer, glycogen, might also be downregulated, since gene sll0726 for phosphoglucomutase and slr1176 for glucose-1-phosphate adenylyltransferase were both significantly downregulated in slr1821 upon NH 4 + stress, while no notable change was observed in WT. Such abnormal redirection of...”
- Glucose-1,6-Bisphosphate, a Key Metabolic Regulator, Is Synthesized by a Distinct Family of α-Phosphohexomutases Widely Distributed in Prokaryotes
Neumann, mBio 2022 - “...sp. PCC 6803 (hereafter Synechocystis ) expresses two enzymes that are encoded by the genes sll0726 and slr1334 and annotated as PGM-like ( 4 , 15 ). While Sll0726 exhibits typical properties of PGMs ( 16 18 ), little is known about Slr1334. The only study...”
- “...Synechocystis Sll0726 has about a 10-fold higher activity in vitro than Slr1334 and that a sll0726 knockout mutant only shows around 3% PGM activity compared to the wildtype ( 19 ). Despite its low contribution to overall PGM activity, the Slr1334 product appeared to be essential...”
- Biochemical elucidation of citrate accumulation in Synechocystis sp. PCC 6803 via kinetic analysis of aconitase
Nishii, Scientific reports 2021 - “...2-nitropropane dioxygenase 25.4 6.1 slr1434 pntB ; pyridine nucleotide transhydrogenase beta subunit K00325 25.4 6.6 sll0726 pgm ; phosphoglucomutase K01835 25.0 7.6 sll0833 OppC in a binding protein-dependent transport system K02034 24.6 8.9 D (citryl-CoA synthetase) sll1023 sucC ; succinateCoA ligase K01903 66.6 6e13 slr0213 guaA...”
- Assessment of Protein Content and Phosphorylation Level in Synechocystis sp. PCC 6803 under Various Growth Conditions Using Quantitative Phosphoproteomic Analysis
Toyoshima, Molecules (Basel, Switzerland) 2020 - “...of the Rubisco large subunit RbcL (Slr0009), Rubisco small subunit RbcS (Slr0012), glycogen-metabolizing enzyme Pgm (Sll0726), and glucose metabolism transcriptional regulator anti-sigB (Slr1856 and Slr1859), among others, were increased ( Figure 2 b). These results suggest that the photosystem and metabolic enzymes are regulated through phosphorylation...”
- Chlorosis as a Developmental Program in Cyanobacteria: The Proteomic Fundament for Survival and Awakening
Spät, Molecular & cellular proteomics : MCP 2018 - “...sp. Resuscitation Molecular & Cellular Proteomics 17.9 tase (Sll0726), namely a 13.6-fold increase at residue Ser63; this protein also had a highly decreased...”
- Diurnal Regulation of Cellular Processes in the Cyanobacterium Synechocystis sp. Strain PCC 6803: Insights from Transcriptomic, Fluxomic, and Physiological Analyses
Saha, mBio 2016 - “...be divided into three broad categories. The first includes genes encoding phosphoglucomutase ( pgm / sll0726 ), glucose-6-phosphate isomerase ( pgi / slr1349 ), phosphoglycerate kinase ( pgk / slr0394 ), sedoheptulose-1,7-bisphosphatase ( glpX / slr2094 ), triosephosphate isomerase ( tpiA / slr0783 ), phosphoglycerate mutase...”
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nfa44530 putative phosphoglucomutase from Nocardia farcinica IFM 10152
58% identity, 96% coverage
- Glycosyltransferases: Mining, engineering and applications in biosynthesis of glycosylated plant natural products
He, Synthetic and systems biotechnology 2022 - “...the control of the PGK1 promoter. At the same time, the Nocardia farcinica phosphoglucomutase gene, nfa44530, which participates in UDP-glucose synthesis, and the E.coli K12 glucose-1-phosphate-1 uridylyltransferase gene, galU, were also co-expressed in the recombinant S.cerevisiae . By optimizing the availability of UDP-glucose, rebaudioside A production...”
- Evolution-aided engineering of plant specialized metabolism
Irfan, aBIOTECH 2021 - “...F3H and FLS1 (A. thaliana); UGT78K1 (Glycine max); nfa44530 (Nocardia farcinia); and galU (E. coli) Malla et al. (2013) Kaempferol 3-Oglucoside (Astragalin) E....”
- “...He et al. (2008) 3-O-xylosyl quercetin E. coli nfa44530 (Nocardia farcinia); galU (E. coli); calS8 and calS9 (Micromonospora echinospora sp. calichenesis); and...”
- A Review on Structure, Modifications and Structure-Activity Relation of Quercetin and Its Derivatives
Magar, Journal of microbiology and biotechnology 2020 - “...(Flavanol-3- O -glucosyltransferse) Oryza sativa / glycosylation of quercetin 12 Quercetin 3- O -xyloside Phosphoglucomutase (nfa44530) Nocardia farcinica / glucose 6 phosphate to glucose 1 phosphate 13 Glucose-1-phosphate uridylyltransferase ( galU ). E. coli K-12 /glucose 1 phosphate to UDP glucose UDP-glucose dehydrogenase ( calS8 )...”
- Glucosylation of isoflavonoids in engineered Escherichia coli
Pandey, Molecules and cells 2014 - “...coli The engineered host E. coli BL21 (DE3)/ pgi zwf ushA harboring recombinant plasmids (pETDuet- nfa44530 - galU and pET28- yjiC ) was used for the whole cell biocatalyst assay. 200 l of overnight culture of the above strain was transferred to 50 ml of TB...”
- “...the engineered E. coli strain E. coli BL21 (DE3)/ pgi zwf ushA over-expressing phosphoglucomutase ( nfa44530 from Nocardia farcinica ) and glucose 1-phosphate uridyl transferase ( galU from E. coli ) ( Fig. 5A ), based on their cell growth ( Malla et al., 2013 ;...”
- Regiospecific modifications of naringenin for astragalin production in Escherichia coli
Malla, Biotechnology and bioengineering 2013 (PubMed)- “...the synthesis of UDP-glucose from G6P, phosphoglucomutase (nfa44530) from Nocardia farcinia and glucose-1-phosphate uridylyltransferase (galU) from E. coli K12...”
- “...AT3G51240 and AT5G08640 from A. thaliana pETDuet-1 carrying nfa44530 from Nocardia farcinica and galU from E.coli K12 pET28a() carrying At5g17050 from A....”
pgmA / I6Y2G3 phosphoglucomutase (EC 5.4.2.2) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
I6Y2G3 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Mycobacterium tuberculosis (see paper)
NP_217584 phosphoglucomutase PgmA from Mycobacterium tuberculosis H37Rv
Rv3068c phosphoglucomutase from Mycobacterium tuberculosis H37Rv
58% identity, 99% coverage
- Heterologous expression and biochemical characterization of recombinant alpha phosphoglucomutase from Mycobacterium tuberculosis H37Rv.
Chhabra, Protein expression and purification 2012 (PubMed)- GeneRIF: The purified recombinant enzyme was enzymatically active with a specific activity of 67.5 U/mg and experimental k(cat) of 70.31 s(-1) for the substrate glucose-1-phosphate.
- A Novel Benzoxaborole Is Active against Escherichia coli and Binds to FabI
Mandal, Antimicrobial agents and chemotherapy 2021 (secret) - A Novel 6-Benzyl Ether Benzoxaborole Is Active against Mycobacterium tuberculosis In Vitro
Patel, Antimicrobial agents and chemotherapy 2017 - “...> 100 M). We isolated resistant mutants (MIC 100 M), which had mutations in Rv1683, Rv3068c, and Rv0047c. KEYWORDS antimicrobial antitubercular drug resistance Anacor Pharmaceuticals Subcontract Theresa O'Malley Bjorn Sunde Lindsay Flint Aaron Korkegian Tanya Parish HHS | NIH | National Institute of Allergy and Infectious...”
- “...1 Profile of resistant mutants d Mutant isolate a MIC 99 (M) b Rv0047c c Rv3068c c Rv1683 c RM1 100 wt wt L341P RM2 >100 E128* T351A wt RM3 >100 wt wt M200I A201T RM4 100 E128* T351A wt a Resistant mutants were isolated on...”
- Characterization of host and microbial determinants in individuals with latent tuberculosis infection using a human granuloma model
Guirado, mBio 2015 - “.../phosphomannomutase (Rv3441c) Mannose 6P to mannose 1P Mannose donor biosynthesis pathway 0.91 1.18 pgmA /phosphomannomutase (Rv3068c) Mannose 6P to mannose 1P Mannose donor biosynthesis pathway 1.08 1.5 manC /GDP-mannose pyrophosphorilase (Rv3264c) Mannose 1P to GDP-mannose Mannose donor biosynthesis pathway 2.84 1.79* ppm1 /polyprenol phosphomannose synthase (Rv2051c)...”
- Investigating the metabolic capabilities of Mycobacterium tuberculosis H37Rv using the in silico strain iNJ661 and proposing alternative drug targets
Jamshidi, BMC systems biology 2007 - “...phosophate (TRE6PS, OtsA, Rv3490) and inositol-phosphate (MI1PS, Ino1, Rv0046c), in addition to phosphoglucomutase (PGMT, PgmA, Rv3068c). These three reactions are required not only for optimal growth, but they are in fact essential for any growth at all in silico . Only one of these, however, has...”
jk0468 hypothetical protein from Corynebacterium jeikeium K411
57% identity, 98% coverage
PFREUD_10610 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) from Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1
58% identity, 99% coverage
- A temporal-omic study of Propionibacterium freudenreichii CIRM-BIA1 adaptation strategies in conditions mimicking cheese ripening in the cold
Dalmasso, PloS one 2012 - “...PFREUD_10590 ylmalonyl-CoA epimerase CH 1 2.3 1.3 0.1 0.146 0.8 1.1 0.8 0.027 48 pgm1 PFREUD_10610 oglucomutase CH 2.1 3.4 3.4 3.4 5.10E-05 3.9 0.01 0.8 0.7 1.1 1.30E-04 29 lpd PFREUD_10890 ihydrolipoyl dehydrogenase CH 0.5 1.5 1.4 2.1 0.018 0.3 0.7 0.5 0.002 34 ldh2...”
- “...ATCAATCGGGTTGAGGTGTG GTTCATCTGGGCGAAGACAT PFREUD_18300 PFREUD_18300 CACGGAGGAGGAGAAGATCA GTACTTCCACAGCTGCACGA PFREUD_20370 PFREUD_20370 ACCTGACCTTCGACATGACC GGGGTACTGAGTGGAGGTGA pgi PFREUD_04290 GAGGCACTCAAGCCCTACAA AGGTCGTGGGTCTTCTCGTA pgm1 PFREUD_10610 CCGAGGTGGAGTTCTTCAGT GACCAGCTTGGACGACAAC ppa PFREUD_23500 TGAAGTCGGTTGATGGTGAG GTTCCAGCTCCTGCTTCATC ppdk PFREUD_03230 ATGCCTCGATGAAGTCCTTG GTGGTGACCGTAAAGCCATC pf279-F1 PFREUD_04340 CGACTCCTACCAGCAGAAGC CATTGTTTGACAAGGCCTGA pspC PFREUD_06710 GATCTGCTGGCTGTTGATCC TCGTAGGGGTTGAAGTCCTG ptsI PFREUD_19470 CGAGATCAAGAACGACACCA GGTTGAAATAGGCGTTCGAC sdaA PFREUD_18570 CGCGGAACTGCTCAATATCT CACCTCGTCCTTCGAGTAGC sdhC2 PFREUD_14320 CTGATGGCTCTCACCGGTAT TCGTTCATGAGCAGCTTCAG...”
Q5SLE0 Phosphoglucomutase from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
55% identity, 97% coverage
TTC1630 No description from Thermus thermophilus HB27
55% identity, 97% coverage
B12L_1523 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) from Bifidobacterium breve 12L
54% identity, 97% coverage
- Glycan cross-feeding activities between bifidobacteria under in vitro conditions
Turroni, Frontiers in microbiology 2015 - “...involved in energy generation through the bif shunt, such as pyruvate kinase (B12L_0681) and phosphoglucomutase (B12L_1523; Figure 3 ). This is consistent with the observation that 12L produces significantly more organic acid endproducts in axenic culture than when co-cultured with another bifidobacterial species. In contrast, the...”
BBMN68_1663 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) from Bifidobacterium longum subsp. longum BBMN68
54% identity, 97% coverage
Blon_2184 phosphoglucomutase, alpha-D-glucose phosphate-specific from Bifidobacterium longum subsp. infantis ATCC 15697
54% identity, 97% coverage
- Structure of co-expression networks of Bifidobacterium species in response to human milk oligosaccharides
González-Morelo, Frontiers in molecular biosciences 2023 - “...included the GNB/LNB and type 1 HMO processing cluster (Blon_2172-Blon_2177), and galactose metabolism enzymes (Blon_2062-Blon_2063, Blon_2184) ( Supplementary Table S1 ). Therefore, this module appears to orchestrate metabolic responses to HMO-derived galactose and fucose. Interestingly, a few genes of the complete HMO cluster I ( Sela...”
- Deciphering bifidobacterial-mediated metabolic interactions and their impact on gut microbiota by a multi-omics approach
Turroni, The ISME journal 2016 - “...encoding a putative 4--glucanotranferase (Blon_0139) and phosphoglucomutase (Blon_2184), especially when this strain was present with B. adolescentis 22L. These...”
- Proteomic analysis of Bifidobacterium longum subsp. infantis reveals the metabolic insight on consumption of prebiotics and host glycans
Kim, PloS one 2013 - “...on lactose, HMO and FOS. However, the alternative galE (Blon_2171) and phosphoglucomutase ( pgm : Blon_2184) were constitutively expressed across all substrates. N-Acetylglucosamine (GlcNAc) is one of the major constituents of HMO. To metabolize this monosaccharide, B. infantis possibly converts GlcNAc to fructose-6-P (Fru-6-P) by deacetylation...”
BL1630 phosphoglucomutase from Bifidobacterium longum NCC2705
54% identity, 97% coverage
- The Pleiotropic Effects of Carbohydrate-Mediated Growth Rate Modifications in Bifidobacterium longum NCC 2705
Duboux, Microorganisms 2023 - “...( galK ), BL1671 ( galE2 ), BL1211 ( galT1 ), BL1643 ( galT2 ), BL1630 ( pgm ) and BL0279 ( pgi )). Notably, two genes ( BL1694 , BL1695 ) that encode an ABC system transporter previously suggested to be involved in arabinose transport...”
- “...transport ( BL0141 ( malE )), channeling of galactose and glucose into the bifid-shunt ( BL1630 ( pgm ), BL1631 ( pgm ), BL0279 ( pgi )). Notably, two of the MalR1 target loci were induced when the strain was grown on glucose, i.e., genes involved...”
- Low-pH adaptation and the acid tolerance response of Bifidobacterium longum biotype longum
Sánchez, Applied and environmental microbiology 2007 - “...7a COGb Carbohydrate transport and metabolism WT ratiog rpe BL0529 BL1630 BL0988 BL0716 BL1644 BL0715 BL0978 BL1341 BL0753 50 60 55 25 34 65 39 30 36 3.49E 13...”
- Lactose-over-glucose preference in Bifidobacterium longum NCC2705: glcP, encoding a glucose transporter, is subject to lactose repression
Parche, Journal of bacteriology 2006 - “...BL0301 AAN24141 BL0301-F1, CAACCGCCGCGATCTTC BL0301-R1, CCAGCTGTGAAAGCAACGTATT BL1630 ( pgm) ered differentially expressed if they displayed an average absolute...”
BCAL_RS04990 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) from Bifidobacterium callitrichos DSM 23973
54% identity, 97% coverage
- The comparative genomics of Bifidobacterium callitrichos reflects dietary carbohydrate utilization within the common marmoset gut
Albert, Microbial genomics 2018 - “...BCAL_RS09090 Starch synthase (maltosyl-transferring) 2.4.99.16 COO72_RS06885 CPA40_RS03955 BCAL_RS11605 Phosphoglucomutase (- d -glucose-1,6-bisphosphate-dependent) 5.4.2.2 COO72_RS10095 CPA40_RS03335 BCAL_RS04990 Protein-N-phosphohistidinecellobiose phosphotransferase 2.7.1.205 COO72_RS05245 CPA40_RS08235 BCAL_RS07995 Amino sugar and nucleotide sugar metabolism UDP- N -acetylmuramate dehydrogenase 1.3.1.98 COO72_RS09690 CPA40_RS03405 BCAL_RS04925 UDP- N -acetylglucosamine 1-carboxyvinyltransferase 2.5.1.7 COO72_RS11030 CPA40_RS10465 BCAL_RS06425 UDP- N...”
- “...CPA40_RS08670 BCAL_RS05265 UDP-glucose 6-dehydrogenase 1.1.1.22 COO72_RS07800 CPA40_RS09840 BCAL_RS07900 Phosphoglucomutase (- d -glucose-1,6-bisphosphate-dependent) 5.4.2.2 COO72_RS10095 CPA40_RS03335 BCAL_RS04990 UTPglucose-1-phosphate uridylyltransferase 2.7.7.9 COO72_RS10475 CPA40_RS09980 BCAL_RS08755 UDP-glucose 4-epimerase 5.1.3.2 COO72_RS04485 CPA40_RS02855 BCAL_RS02635 Galactokinase 2.7.1.6 COO72_RS01650 CPA40_RS06710 BCAL_RS05755 UDP-glucosehexose-1-phosphate uridylyltransferase 2.7.7.12 COO72_RS11900 CPA40_RS05725 BCAL_RS05750 UDP-galactopyranose mutase 5.4.99.9 COO72_RS07765 CPA40_RS11110 BCAL_RS07940 Phosphoglucomutase...”
CPA40_RS03335 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) from Bifidobacterium callitrichos
54% identity, 97% coverage
- The comparative genomics of Bifidobacterium callitrichos reflects dietary carbohydrate utilization within the common marmoset gut
Albert, Microbial genomics 2018 - “...CPA40_RS09325 BCAL_RS09090 Starch synthase (maltosyl-transferring) 2.4.99.16 COO72_RS06885 CPA40_RS03955 BCAL_RS11605 Phosphoglucomutase (- d -glucose-1,6-bisphosphate-dependent) 5.4.2.2 COO72_RS10095 CPA40_RS03335 BCAL_RS04990 Protein-N-phosphohistidinecellobiose phosphotransferase 2.7.1.205 COO72_RS05245 CPA40_RS08235 BCAL_RS07995 Amino sugar and nucleotide sugar metabolism UDP- N -acetylmuramate dehydrogenase 1.3.1.98 COO72_RS09690 CPA40_RS03405 BCAL_RS04925 UDP- N -acetylglucosamine 1-carboxyvinyltransferase 2.5.1.7 COO72_RS11030 CPA40_RS10465 BCAL_RS06425 UDP-...”
- “...COO72_RS12210 CPA40_RS08670 BCAL_RS05265 UDP-glucose 6-dehydrogenase 1.1.1.22 COO72_RS07800 CPA40_RS09840 BCAL_RS07900 Phosphoglucomutase (- d -glucose-1,6-bisphosphate-dependent) 5.4.2.2 COO72_RS10095 CPA40_RS03335 BCAL_RS04990 UTPglucose-1-phosphate uridylyltransferase 2.7.7.9 COO72_RS10475 CPA40_RS09980 BCAL_RS08755 UDP-glucose 4-epimerase 5.1.3.2 COO72_RS04485 CPA40_RS02855 BCAL_RS02635 Galactokinase 2.7.1.6 COO72_RS01650 CPA40_RS06710 BCAL_RS05755 UDP-glucosehexose-1-phosphate uridylyltransferase 2.7.7.12 COO72_RS11900 CPA40_RS05725 BCAL_RS05750 UDP-galactopyranose mutase 5.4.99.9 COO72_RS07765 CPA40_RS11110 BCAL_RS07940...”
DR0303 phosphoglucomutase from Deinococcus radiodurans R1
61% identity, 33% coverage
GSU3321 phosphoglucomutase/phosphomannomutase family protein from Geobacter sulfurreducens PCA
31% identity, 88% coverage
VP2488 putative phosphoglucomutase/phosphomannomutase from Vibrio parahaemolyticus RIMD 2210633
27% identity, 88% coverage
TTC0291 No description from Thermus thermophilus HB27
Q5SKJ3 Phosphoglucomutase/phosphomannomutase from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
TTHA0650 putative phosphoglucomutase/phosphomannomutase from Thermus thermophilus HB8
29% identity, 90% coverage
VC0611 phosphoglucomutase/phosphomannomutase, putative from Vibrio cholerae O1 biovar eltor str. N16961
28% identity, 88% coverage
- The Infectious Dose Shapes Vibrio cholerae Within-Host Dynamics
Gillman, mSystems 2021 - “...17 ). Briefly, a 1,055-bp fragment that included 93bp of intergenic region between VC0610 and VC0611 of V. cholerae , and a 30-bp random sequence was inserted into the suicide plasmid pG704. The plasmid constructs were transferred to V. cholerae by conjugation with SM10 lambda pir...”
- Chitin Heterodisaccharide, Released from Chitin by Chitinase and Chitin Oligosaccharide Deacetylase, Enhances the Chitin-Metabolizing Ability of Vibrio parahaemolyticus
Hirano, Journal of bacteriology 2019 (secret) - Growth on Chitin Impacts the Transcriptome and Metabolite Profiles of Antibiotic-Producing Vibrio coralliilyticus S2052 and Photobacterium galatheae S2753
Giubergia, mSystems 2017 - “...is separated from the other genes ( Fig.2 ). As for the (GlcNAc) 2 operon (VC0611 to VC0620 in V.cholerae ), it is completely present in the genome of V.coralliilyticus S2052, but we did not detect any gene homolog of VC0611 or VC0612 in the genome...”
- “...respectively (see Fig.S5 in the supplemental material). In contrast, the lack of homologs of the VC0611 (GlcNAc-1-phosphate mutase) and VC0612 [(GlcNAc) 2 phosphorylase] genes in the (GlcNAc) 2 operon of P.galatheae seems to be a peculiarity only of this strain and of the very closely related...”
- Quorum sensing-regulated chitin metabolism provides grazing resistance to Vibrio cholerae biofilms
Sun, The ISME journal 2015 - “...V. cholerae WT and hapR biofilms in GlcNAc catabolism Gene Description hapR /WT log2 fold VC0611 Phosphoglucomutase/phosphomannomutase 1.74 VC0612 Cellobiose/cellodextrin-phosphorylase 1.92 VC0613 Beta- N -acetylhexosaminidase 1.54 VC0614 Hypothetical protein 1.55 VC0615 Endoglucanase-like protein 1.01 VC0616 Peptide ABC transporter ATP-binding protein 1.63 VC0617 Peptide ABC transporter ATP-binding...”
- Sequence tag-based analysis of microbial population dynamics
Abel, Nature methods 2015 - “...bp fragment of VC0610 that included 93 bp of the intergenic region between VC0610 and VC0611 was amplified using primer P110 that contained a 30 bp stretch of random sequence and P80 and inserted into pSoA160 at the SacI and XbaI sites, yielding pSoA158.mix. The correct...”
- ARTIST: high-resolution genome-wide assessment of fitness using transposon-insertion sequencing
Pritchard, PLoS genetics 2014 - “...and lacZ - V. cholerae were then barcoded at the intergenic region between vc0610 and vc0611 with unique 30 bp random sequence tags. The barcoding does not impact bacteria fitness in vitro or in vivo ( Figure S5C ), and each strain was independently tagged with...”
- The chitinolytic cascade in Vibrios is regulated by chitin oligosaccharides and a two-component chitin catabolic sensor/kinase
Li, Proceedings of the National Academy of Sciences of the United States of America 2004 - “...cholerae, a cluster of 10 contiguous genes (VC0620 -VC0611) apparently comprise a (GlcNAc)2 catabolic operon. CBP is encoded by the first, VC0620, whereas...”
- “...genes are part of 10 contiguous genes, from VC0611 to VC0620. VC0616-VC0620 encodes an ABC-type transporter specific for (GlcNAc)2 and possibly (GlcNAc)3. We...”
O66791 Phosphoglucomutase/phosphomannomutase from Aquifex aeolicus (strain VF5)
aq_501 phosphoglucomutase/phosphomannomutase from Aquifex aeolicus VF5
27% identity, 90% coverage
- Proteomics investigations of HDL: challenges and promise.
Vaisar, Current vascular pharmacology 2012 - “...beta-2-glycoprotein 1 APOH 350 P02749 IPI00298828 APOH_HUMAN 2 56 , 53 apolipoprotein L1 APOL1 8542 O66791 IPI00186903 APOL1_HUMAN 7 59 , 56 , 63 , 55 , 54 , 72 , 53 apolipoprotein M APOM 55937 O95445 IPI00030739 APOM_HUMAN 5 56 , 55 , 54 ,...”
- Experimental RNomics in Aquifex aeolicus: identification of small non-coding RNAs and the putative 6S RNA homolog
Willkomm, Nucleic acids research 2005 - “...complementary over its 21 nt to transcripts of two annotated protein genes ( aq_512 and aq_501 = pmu , phosphoglucomutase/phospho-mannomutase), separated by 8 kb, which are almost identical over 660 nt of their N-terminal coding sequences, indicating that they are paralogs ( Figure 2A ). A...”
all3964 phosphoglucomutase/phosphomannomutase from Nostoc sp. PCC 7120
27% identity, 92% coverage
- Induction and differential expression of certain novel proteins in Anabaena L31 under UV-B radiation stress
Babele, Frontiers in microbiology 2015 - “...PI Mascot score Functional domain (InterPro Scan) E.C. no./pathway Expression level Carbohydrate metabolism 2 Phosphoglucomutase/phosphomannomutase all3964 17231542 475 51819.9 5.1 160 IPR005841 Alpha- D -phosphohexomutase_SF 5.4.2.8 Down 8 Fructose-1,6-bisphosphate aldolase all4563 17232055 359 38616.7 5.4 82.4 IPR000771 Ketose_bisP_aldolase_II 4.1.2.13 Down 9 Glucose-6-phosphate isomerase alr1050 17228545 528...”
- “...it may partly meet the reductant requirement for vital metabolic processes. Down regulation of phosphoglucomutase (all3964) following exposure of Anabaena L31 cells to UV-B is an interesting observation and to our knowledge not reported from any other species of cyanobacteria. Phosphoglucomutase may have significant role under...”
- The Anabaena sp. PCC 7120 Exoproteome: Taking a Peek outside the Box
Oliveira, Life (Basel, Switzerland) 2015 - “...decarboxylase NO 3 , NH 4 + Biosynthesis of cofactors, prosthetic groups, and carriers - All3964 Phosphoglucomutase/phosphomannomutase N 2 , NO 3 , NH 4 + Central intermediary metabolism Anabaena All3984 All3984 protein N 2 Conserved hypothetical protein N. punctiforme All4038 All4038 protein NH 4 +...”
- “...Alr1004, Alr1313, Alr2771, Alr0608, Alr1080, Alr2328 Alr4907, All1683, All4464), sugar breakdown and processing (Alr3608, Alr4448, All3964, All0167, All0168, All0875, Alr0169, Alr2190, All4539) and phosphor scavenge and transport (All0207, All2843, All4575, Alr4238, Alr4976). Detection of these proteins suggests that the processes carried out by Anabaena sp. PCC...”
Ava_1737 Phosphoglucomutase/phosphomannomutase from Anabaena variabilis ATCC 29413
26% identity, 93% coverage
DR_A0047 phospho-sugar mutase, putative from Deinococcus radiodurans R1
28% identity, 88% coverage
- Development and Regulation of the Extreme Biofilm Formation of Deinococcus radiodurans R1 under Extreme Environmental Conditions
Guo, International journal of molecular sciences 2023 - “...there are DEGs in the drRRA mutant that participate in sugar metabolism, including dr_1480 , dr_A0047 , dr_A0031 , and dr_1689 . Among these, dr_1480 , a member of the dr_1473-dr_1483 gene cluster based on KEGG prediction, encodes alginate biosynthesis protein (AlgP); alginate is reported to...”
- Essentiality of threonylcarbamoyladenosine (t(6)A), a universal tRNA modification, in bacteria
Thiaville, Molecular microbiology 2015 - “...hypothetical protein 6.3 1.00E-05 1 DR_0608 Histone acetyltransferase HPA2 and related acetyltransferases 5.0 1.64E-03 1 DR_A0047 Phosphomannomutase (EC 5.4.2.8) / Phosphoglucomutase (EC 5.4.2.2) 4.9 5.94E-03 1 DR_B0125 iron ABC transporter, periplasmic substrate-binding protein 4.3 3.49E-04 DR_1335 Isoleucyl-tRNA synthetase (EC 6.1.1.5) 3.7 3.43E-03 1 DR_1063 Peptidyl-prolyl cis-trans...”
FSU_0773 phosphomannomutase from Fibrobacter succinogenes subsp. succinogenes S85
27% identity, 88% coverage
PGMMM_THEKO / Q68BJ6 Phosphoglucomutase/phosphomannomutase; PGM/PMM; EC 5.4.2.2; EC 5.4.2.8 from Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1)) (see paper)
TK1108 phosphohexomutase from Thermococcus kodakaraensis KOD1
25% identity, 92% coverage
- function: Catalyzes the interconversion of glucose 1-phosphate and glucose 6-phosphate, and the interconversion of mannose 1-phosphate and mannose 6-phosphate. Also displays low activity with deoxyribose 1- phosphate and glucosamine 1-phosphate.
catalytic activity: alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate (RHEA:23536)
catalytic activity: alpha-D-mannose 1-phosphate = D-mannose 6-phosphate (RHEA:11140)
cofactor: Mg(2+) (Can also use Ni(2+), Mn(2+) and Zn(2+), to a lesser extent.)
subunit: Homotetramer. - Bacterial α-diglucoside metabolism: perspectives and potential for biotechnology and biomedicine
Garcia, Applied microbiology and biotechnology 2021 - “...-D-glucose-1-phosphate that was subsequently converted into -D-glucose-6-phosphate by -phosphoglucomutase from Thermococcus kodakarensis KOD1 (locus ID: TK1108). The -D-glucose-6-phosphate was then converted to -D-glucose-1-phosphate by -phosphoglucomutase from Lactococcus sp. (Sigma-Aldrich; product ID P4109). The final step in the one-pot reaction had Cphy 1874 combine -D-glucose-1-phosphate and D-glucose...”
- Acceleration of cellodextrin phosphorolysis for bioelectricity generation from cellulosic biomass by integrating a synthetic two-enzyme complex into an in vitro synthetic enzymatic biosystem
Meng, Biotechnology for biofuels 2019 - “...C-terminal 6 His tag expression gene [ 37 ]. Plasmid pET20b-tkpgm had a tkpgm gene (Tk1108) encoding phosphoglucomutase from T. kodakaraensis and a C-terminal 6 His tag expression gene [ 10 ]. Plasmid pET20b-ctcdp-ctdoc contained an expression cassette of the ctcdp gene and a dockerin module...”
- An In Vitro Enzyme System for the Production of myo-Inositol from Starch
Fujisawa, Applied and environmental microbiology 2017 - “...(PGM), which we have previously characterized, encoded by TK1108 (43). It is therefore possible that this organism converts maltooligosaccharides to G6P via...”
- “...putative MalP gene (TK1406) and a PGM encoded by TK1108, it would be possible to convert maltodextrin to myoinositol without the stoichiometric consumption of a...”
- Among multiple phosphomannomutase gene orthologues, only one gene encodes a protein with phosphoglucomutase and phosphomannomutase activities in Thermococcus kodakaraensis
Rashid, Journal of bacteriology 2004 - “...April 2004/Accepted 8 June 2004 Four orthologous genes (TK1108, TK1404, TK1777, and TK2185) that can be annotated as phosphomannomutase (PMM) genes (COG1109)...”
- “...and characterization of the recombinant protein indicated that TK1108 encoded a protein with high levels of PGM activity (690 U mg1), along with high...”
FTA_0510 phosphoglucomutase from Francisella tularensis subsp. holarctica FTA
27% identity, 90% coverage
- Population Genomics of Francisella tularensis subsp. holarctica and its Implication on the Eco-Epidemiology of Tularemia in Switzerland
Wittwer, Frontiers in cellular and infection microbiology 2018 - “...5 non-synonymous SNPs are found in genes coding for proteins involved in the carbohydrate ( FTA_0510, FTA_1026, FTA_1126) and fatty-acid ( FTA_0617 ) metabolism of Fth (Table 3 ). Table 3 List of the non-synonymous SNPs identified with the breseq pipeline. Position Mutation Annotation Gene Description...”
- “...GAT) FTA_0224 Hypothetical membrane protein/putative cytochrome c-type biogenesis protein 468941 C T T425I (ACT ATT) FTA_0510 Phosphoglucomutase/phosphomannomutase 563329 C T G221R (GGG AGG) FTA_0617 Acetyl-CoA acetyltransferase 944751 G T S162I (AGT ATT) FTA_1026 Iron-containing alcohol dehydrogenase 1022282 G T R456M (AGG ATG) FTA_1126 Phosphorylase family 2/alpha-beta...”
- Complete genome sequence of Francisella tularensis subspecies holarctica FTNF002-00
Barabote, PloS one 2009 - “...protein FTA_0329 GD 1 dihydrolipoamide acetyltransferase C FTA_1126 GD 1 phosphorylase family 2 protein F FTA_0510 IT 1 phosphoglucomutase G FTA_1126 MR 1 phosphorylase family 2 protein F FTA_1286 PS 1 hypothetical protein K FTA_0658 PT 1 glycosyl transferase M FTA_1509 SR 1 HAD family hydrolase...”
CLIBASIA_05045 phosphoglucomutase from Candidatus Liberibacter asiaticus str. psy62
25% identity, 92% coverage
OFBG_01422 alpha-D-glucose phosphate-specific phosphoglucomutase from Oxalobacter formigenes OXCC13
29% identity, 76% coverage
- Proteome Dynamics of the Specialist Oxalate Degrader Oxalobacter formigenes
Ellis, Journal of proteomics & bioinformatics 2016 - “...and cells from stationary phase relative to log phase cells had higher levels of phosphoglucomutase (OFBG_01422), suggesting glycogen breakdown is important for prolonging survival of O. formigenes in the absence of oxalate. Proteins associated with metabolism of lipids included a thioesterase-like protein (OFBG_01426), a carboxylesterase-like protein...”
FTL_RS02540 alpha-D-glucose phosphate-specific phosphoglucomutase from Francisella tularensis subsp. holarctica LVS
27% identity, 90% coverage
K1PQD4 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) from Magallana gigas
27% identity, 70% coverage
Q16U43 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) from Aedes aegypti
29% identity, 73% coverage
PGM_DROME / Q9VUY9 Phosphoglucomutase 1; PGM; Glucose phosphomutase; EC 5.4.2.2 from Drosophila melanogaster (Fruit fly) (see 2 papers)
29% identity, 76% coverage
- function: Catalyzes the reversible isomerization of alpha-D-glucose 1- phosphate to alpha-D-glucose 6-phosphate (PubMed:44190). The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate (PubMed:44190). This enzyme participates in both the breakdown and synthesis of glucose (PubMed:44190). Enzyme of the glycolytic pathway (Probable). Glycolysis is essential in glial cells but not in neurons; neurons rely on the citric acid cycle for their energy needs, and on lactate and alanine secreted into the hemolymph by glial cells to fuel it (PubMed:26235423).
catalytic activity: alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate (RHEA:23536)
catalytic activity: O-phospho-L-seryl-[protein] + alpha-D-glucose 1-phosphate = alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] (RHEA:68748)
catalytic activity: alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] = O- phospho-L-seryl-[protein] + alpha-D-glucose 6-phosphate (RHEA:68752)
cofactor: Mg(2+) (Binds 1 Mg(2+) ion per subunit.)
subunit: Monomer.
disruption phenotype: RNAi-mediated knockdown is lethal (PubMed:26235423). Glial-specific RNAi-mediated knockdown is viable but eclosed adults present with locomotor defects (PubMed:26235423). Neuronal-specific RNAi-mediated knockdown is viable with no defects (PubMed:26235423). - Proteomic characterization of inbreeding-related cold sensitivity in Drosophila melanogaster
Vermeulen, PloS one 2013 - “...As above 8406 CG3590 Q9VEP6 89E889E8 8502 CG10924, isoform A Q7JXB5 55D155D2 8503 phosphogluconate mutase Q9VUY9 72D872D8 8505 CG8036, isoform B Q9VHN7 85A585A5 8508 CG8036, isoform B See SN8505 See SN8505 List of identified proteins for every spot, together with their Uniprot accession number and the...”
NX02_14005 alpha-D-glucose phosphate-specific phosphoglucomutase from Sphingomonas sanxanigenens DSM 19645 = NX02
30% identity, 72% coverage
CAC2337 Phosphomannomutase from Clostridium acetobutylicum ATCC 824
26% identity, 83% coverage
- Transcriptional analysis of spo0A overexpression in Clostridium acetobutylicum and its effect on the cell's response to butanol stress
Alsaker, Journal of bacteriology 2004 - “...encoding glucose-6-phosphate isomerase), a phosphomannomutase gene (CAC2337), and the mother cell-specific sigma factor sigE (CAC1695). Several genes, including...”
- DNA array-based transcriptional analysis of asporogenous, nonsolventogenic Clostridium acetobutylicum strains SKO1 and M5
Tomas, Journal of bacteriology 2003 - “...of sugar metabolism (CAC0231), a phosphomannomutase gene (CAC2337), amyP (CAP0168), a glucoamylase gene (CAC2810), and an endoglucanase gene (CAC2556)....”
SSU05_0686 Phosphomannomutase from Streptococcus suis 05ZYH33
26% identity, 87% coverage
PH0923 / O58651 phosphomannose mutase (EC 5.4.2.8) from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) (see paper)
1wqaA / O58651 Crystal structure of pyrococcus horikoshii phosphomannomutase/phosphoglucomutase complexed with mg2+
O58651 455aa long hypothetical phospho-sugar mutase from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
PH0923 phospho-sugar mutase from Pyrococcus horikoshii OT3
25% identity, 88% coverage
- Ligand: magnesium ion (1wqaA)
- Biology, Mechanism, and Structure of Enzymes in the α-d-Phosphohexomutase Superfamily.
Stiers, Advances in protein chemistry and structural biology 2017 - “...Mg G6P T. thermophilus bacterial Q5SKJ3 1TUO 464 1.70 No (pH 4.4) P. horikoshii archaea O58651 1WQA 455 2.00 N Mg tetramer S. tokodaii archaea Q976E4 2F7L 455 2.80 N No (pH 5.4) tetramer * In cases of multiple structures, only the highest resolution listed. Ligand...”
- Identification and characterization of a thermostable bifunctional enzyme with phosphomannose isomerase and sugar-1-phosphate nucleotidylyltransferase activities from a hyperthermophilic archaeon, Pyrococcus horikoshii OT3
Akutsu, Extremophiles : life under extreme conditions 2015 (PubMed)- “...accompanied by a phosphomannomutase/phosphoglucomutase (PMM/PGM) enzyme (PH0923). The recombinant PH0925 protein, expressed in E. coli, exhibited both expected...”
- “...genes encoding phosphomannomutase/phosphoglucomutase (PMM/PGM: PH0923), phosphomannose isomerase/mannose-1-phosphate guanylyltransferase (PMI/ Man-1-P GTase:...”
- Characterization of a thermostable enzyme with phosphomannomutase/phosphoglucomutase activities from the hyperthermophilic archaeon Pyrococcus horikoshii OT3
Akutsu, Journal of biochemistry 2005 (PubMed)- “...searches using existing PMM/PGM sequences, the homologous ORFs PH0923 and PH1210 were identified from the genomic data of Pyrococcus horikoshii OT3. Since...”
- “...an operon consisting of four carbohydrate metabolic enzymes, PH0923 was selected as the first target for the investigation of PMM/PGM activity in P. horikoshii...”
- Among multiple phosphomannomutase gene orthologues, only one gene encodes a protein with phosphoglucomutase and phosphomannomutase activities in Thermococcus kodakaraensis
Rashid, Journal of bacteriology 2004 - “...AAL80985; P. furiosus PF1729, AAL81853; P. horikoshii PH0923, BAA30019; P. horikoshii PH1210, BAA30310; P. horikoshii PH1696, BAA30809; T. kodakaraensis TK1108,...”
- “...Pyrococcus genomes. TK1108 was closely related to PF0588, PH0923, and PAB0819, suggesting that the latter three genes may encode the PGM/PMMs in their...”
- Pathway for the synthesis of mannosylglycerate in the hyperthermophilic archaeon Pyrococcus horikoshii. Biochemical and genetic characterization of key enzymes
Empadinhas, The Journal of biological chemistry 2001 (PubMed)- “...(PH0925) and as a putative phosphomannose mutase (PH0923). Genes PH0927, PH0926, PH0925, and PH0923 were contained in an operon-like structure, leading...”
- “...revealed two ORFs (PH0925 and PH0923) putatively identified as mannose-1-phosphate-guanylyltransferase/phosphomannose isomerase (M1P-GT/PMI, EC 2.7.7.22/EC...”
FTT_0414 phosphoglucomutase from Francisella tularensis subsp. tularensis SCHU S4
27% identity, 90% coverage
- Formation of the Francisella tularensis Biofilm is Affected by Cell Surface Glycosylation, Growth Medium, and a Glucan Exopolysaccharide
Champion, Scientific reports 2019 - “...FTT_0413 glgB 1,4--glucanotransferase Clostridium perfringens -63% 1,922 FTL_RS02535 glycogen branching enzyme F . tularensis LVS-99% FTT_0414 pgm -D-glucose phosphoglucomutase Massilia spp.-68% 1,634 FTL_RS02540 F . tularensis LVS-99% FTT_0415 glgC Pseudo 1,269 FTLRS02545 glucose-1-phosphate adenylyltransferase Lachnospiraceae spp.-63% 1,271 F . tularensisLVS -99% FTT_0416 glgA glycogen synthase Burkholderia...”
- Increased knowledge of Francisella genus diversity highlights the benefits of optimised DNA-based assays
Ahlinder, BMC microbiology 2012 - “..., 61 ] 28-pdpD FTT_1360c, FTT_1715c 136 1403503-638, 1796838-973 [ 56 , 60 ] 29-pgm FTT_0414 650 425033-682 [ 18 , 61 ] 30-prfB FTT_0191 376 207686-8061 [ 19 ] 31-putA FTT_1150c 415 1165411-825 [ 19 ] 32-rpoA FTT_0350, FTT_1442c 914 349619-50532 [ 64 ] 33-rpoB...”
FTN_0514 phosphoglucomutase from Francisella tularensis subsp. novicida U112
27% identity, 90% coverage
- Francisella novicida Two-Component System Response Regulator BfpR Modulates iglC Gene Expression, Antimicrobial Peptide Resistance, and Biofilm Production
Dean, Frontiers in cellular and infection microbiology 2020 - “...overexpression (1.46-fold for glgX; 0.42, 0.377, 0.145, 0.565, 0.436-fold, respectively, for the rest), while pgm (FTN_0514) and glgP (FTN_0517) were down regulated in the bfpR mutant vs. WT (0.466-fold and 0.551-fold, respectively). Our results indicated that mutation of bfpR increased biofilm formation and polysaccharide levels, as...”
- Importance of Metabolic Adaptations in Francisella Pathogenesis
Ziveri, Frontiers in cellular and infection microbiology 2017 - “...non-oxidative part of the Pentose Phosphate Pathway. Gene numbers in F. novicida : pgm ( FTN_0514 ); pgi ( FTN_0663 ); gpml ( FTN_0648 ); eno ( FTN_0621 ); glpX ( FTN_0298 ); pfk ( FTN_1210 ); ( FTN_1631 ); glpD ( FTN_1584 ); glpK (...”
- Working toward the future: insights into Francisella tularensis pathogenesis and vaccine development
Pechous, Microbiology and molecular biology reviews : MMBR 2009 - “...213 213 213 213 FTN_0504 FTN_0505 FTN_0506 FTN_0507 FTN_0514 FTN_0536 FTN_0537 FTN_0544 FTN_0545 FTN_0546 cadA gcvT gcvH gcvP1 pgm yjjK FTN_0537 FTN_0544 flmF2...”
PF0588 phospho-sugar mutase from Pyrococcus furiosus DSM 3638
25% identity, 92% coverage
- Genome-wide binding analysis of the transcriptional regulator TrmBL1 in Pyrococcus furiosus
Reichelt, BMC genomics 2016 - “...ferredoxin oxidoreductase - downstream singleton PF0477 alpha-amylase cytoplasmatic upstream singleton PF0478 alpha-amylase - downstream singleton PF0588 phospho-sugar mutase - downstream operon PF1109 hypothetical protein one gene product: extracellular starch-binding protein downstream operon PF1110 hypothetical protein singleton PF1784 ADP-specific phosphofructokinase - downstream singleton PF1874 glyceraldehyde-3-phosphate dehydrogenase -...”
- “...oxidoreductase; PF0477, proposed extracellular -amylase. PF0478, proposed extracellular cyclomaltodextrin glucano-transferase; PF0505, putative DNA binding protein; PF0588, phosphoglucose mutase; PF0853, 5'-methylthioadenosine phosphorylase; PF0874, membrane dipeptidase; PF0967-PF0965, pyruvate ferredoxin oxidoreductase; PF1109/1110, extracellular starch-binding protein; PF1350, proposed single-component transport protein; PF1476, putative PadR-like regulator; PF1535, maltodextrin phosphorylase; PF1539, dihydroorotate...”
- The TrmB family: a versatile group of transcriptional regulators in Archaea
Gindner, Extremophiles : life under extreme conditions 2014 - “...is also proposed for a potential glycolytic regulon of P. furiosus including a phospho-sugar mutase (PF0588) and three -amylase encoding genes (PF0272, PF0478 and PF0477), as all of the corresponding promoters contain a TGM downstream of the BRE/TATA box (van de Werken et al. 2006 )....”
- Experimental and computational analysis of the secretome of the hyperthermophilic archaeon Pyrococcus furiosus
Schmid, Extremophiles : life under extreme conditions 2013 - “...PF0272 1351936 Alpha-amylase 76 10 15 No PF0456 18892427 Carboxypeptidase 1 59 8 12 No PF0588 18892584 Phospho-sugar mutase 50 7 19 No PF0597 18976969 IAA-amino acid hydrolase 49 4 10 No PF0751 18892770 Flavoprotein 47 5 14 No PF0825 18892854 Prolyl endopeptidase 71 6 11...”
- Novel multiprotein complexes identified in the hyperthermophilic archaeon Pyrococcus furiosus by non-denaturing fractionation of the native proteome
Menon, Molecular & cellular proteomics : MCP 2009 - “...I (Fba1) Agmatinase 6.0 5.2 5.3 5.6 7.5 5.6 PF0588 PF0589 PF0868 PF0869 PF1203 PF1204 PF1205 PC-67 PC-87 PC-90 PF1640 PF1641 PF1931 PF1932 PC-96 PF1993 PF1994...”
- Impact of substrate glycoside linkage and elemental sulfur on bioenergetics of and hydrogen production by the hyperthermophilic archaeon Pyrococcus furiosus
Chou, Applied and environmental microbiology 2007 - “...be converted into glucose-6-phosphate by phosphoglucomutase (PF0588) (3) or directed into polysaccharide biosynthesis (40). PF0272 was significantly...”
- “...the culture containing only maltose. However, PF0312 and PF0588, which control the influx to the glycolytic pathway, responded indifferently to maltose and...”
- Transcriptional and biochemical analysis of starch metabolism in the hyperthermophilic archaeon Pyrococcus furiosus
Lee, Journal of bacteriology 2006 - “...PF0132 PF0272 PF0312 PF0477 PF0478* PF0588 PF1256 PF1535 PF1739 -Glucosidase 4--Glucanotransferase ADP-dependent glucokinase -Amylase Cyclomaltodextrin...”
- “...is converted to glucose-6-phosphate by phosphoglucose mutase (PF0588), and the glucose produced by PF0272 is converted to glucose-6phosphate by PF0312, a...”
- Among multiple phosphomannomutase gene orthologues, only one gene encodes a protein with phosphoglucomutase and phosphomannomutase activities in Thermococcus kodakaraensis
Rashid, Journal of bacteriology 2004 - “...CAB50141; P. abyssi PAB1666, CAB49971; P. furiosus PF0588, AAL80712; P. furiosus PF0861, AAL80985; P. furiosus PF1729, AAL81853; P. horikoshii PH0923, BAA30019;...”
- “...in three Pyrococcus genomes. TK1108 was closely related to PF0588, PH0923, and PAB0819, suggesting that the latter three genes may encode the PGM/PMMs in their...”
- Biochemical adaptations of two sugar kinases from the hyperthermophilic archaeon Pyrococcus furiosus
Verhees, The Biochemical journal 2002 - “...galactose are present in P. furiosus (PF0445, PF0441, PF1788, PF0588) and the constitutive activity of a key enzyme of galactose metabolism, i.e. GALK, could be...”
P93262 Phosphoglucomutase, cytoplasmic from Mesembryanthemum crystallinum
29% identity, 67% coverage
- Protein profile of Beta vulgaris leaf apoplastic fluid and changes induced by Fe deficiency and Fe resupply.
Ceballos-Laita, Frontiers in plant science 2015 - “...C, , nCS, nCS, Glycolytic process 1 2,3-Bisphosphoglycerate-independent phosphoglycerate mutase Q42908 Glycolytic process 1 Phosphoglucomutase P93262 Glucose metabolic process 3 Glyceraldehyde-3-phosphate dehydogenase A3FMH0 Glucose metabolic process 2 Ribose-5-phosphate isomerase Q8RU73 C nCS PPS, non-oxidative branch 1 Ribulose-phosphate 3-epimerase Q43157 C nCS Calvin cycle; PPS, oxidative branch...”
- A proteomic analysis of Curcuma comosa Roxb. rhizomes
Boonmee, Proteome science 2011 - “...A40 Q0ZIZ4 ATP-dependent Clp protease proteolytic subunit Vitis vinifera 5 1 22,060 4.75 Proteolysis B4 P93262 Phosphoglucomutase Mesembryanthemum crystallinum 2 1 63,446 5.87 Metabolism B5 Q94CI8 Glycine-rich protein Solanum lycopersicum 2 1 23,420 5.88 Unknown B6 Q1PCD2 glucose 6 phosphate isomerase Solanum lycopersicum 5 2 62,739...”
I5AUJ3 Phosphoglucomutase from Eubacterium cellulosolvens (strain ATCC 43171 / JCM 9499 / 6)
28% identity, 89% coverage
PAB0819 PHOSPHOMANNOMUTASE (PMM) from Pyrococcus abyssi GE5
25% identity, 92% coverage
- Among multiple phosphomannomutase gene orthologues, only one gene encodes a protein with phosphoglucomutase and phosphomannomutase activities in Thermococcus kodakaraensis
Rashid, Journal of bacteriology 2004 - “...as follows: P. abyssi PAB0318, CAB49399; P. abyssi PAB0819, CAB50141; P. abyssi PAB1666, CAB49971; P. furiosus PF0588, AAL80712; P. furiosus PF0861, AAL80985;...”
- “...TK1108 was closely related to PF0588, PH0923, and PAB0819, suggesting that the latter three genes may encode the PGM/PMMs in their organisms. Interestingly, all...”
all5089 phosphoglucomutase/phosphomannomutase from Nostoc sp. PCC 7120
25% identity, 90% coverage
GQS78_06950 phosphoglucosamine mutase from Thermococcus bergensis
25% identity, 92% coverage
LGG_00921 phospho-sugar mutase from Lacticaseibacillus rhamnosus GG
LGG_00921 phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I, II & III from Lactobacillus rhamnosus GG
25% identity, 86% coverage
- Growth phase-associated changes in the proteome and transcriptome of Lactobacillus rhamnosus GG in industrial-type whey medium
Laakso, Microbial biotechnology 2011 - “...lacD Tagatose 1,6diphosphate aldolase 18 4 0.07 Glycolysis/gluconeogenesis LGG_00524 fba Fructosebisphosphate aldolase 19 1.5 1.97 LGG_00921 pgm Phosphoglucomutase 20 1.5 1.686 LGG_00933 gapA Glyceraldehyde3phosphate dehydrogenase 2125 2.9 0.644 LGG_00933 gapA Glyceraldehyde3phosphate dehydrogenase 26,27 1.8 0.644 LGG_00934 pgk Phosphoglycerate kinase 28,29,30 a 3.1 0.286 LGG_00935 tpiA Triosephosphate...”
- “...phosphotransferase system repressor 142 15.9 6.699 LGG_02575 lacD Tagatose 1,6diphosphate aldolase 143,144 2.1 1.145 Glycolysis/gluconeogenesis LGG_00921 pgm Phosphoglucomutase 145 1.9 1.331 LGG_00933 gapA Glyceraldehyde3phosphate dehydrogenase 146,147 1.6 0.239 LGG_00933 gapA Glyceraldehyde3phosphate dehydrogenase 148 2.9 0.239 LGG_01375 pyk Pyruvate kinase 149,150 2 2.596 LGG_01375 pyk Pyruvate kinase...”
XP_011070593 phosphoglucomutase, cytoplasmic from Sesamum indicum
29% identity, 67% coverage
PMM0076 Phosphoglucomutase from Prochlorococcus marinus sp. MED4
25% identity, 89% coverage
- Interplay and Targetome of the Two Conserved Cyanobacterial sRNAs Yfr1 and Yfr2 in Prochlorococcus MED4
Lambrecht, Scientific reports 2019 - “...Yfr10 (Fig. S5 ). In contrast to ppa , argJ and phosphoglucomutase ( pgm , PMM0076) are targeted by Yfr1 but not Yfr10 (Fig. 5 ). Amongst the specific targets of Yfr10 are atpA and atpC , which encode the and subunits of the F 1...”
- Convergent evolution toward an improved growth rate and a reduced resistance range in Prochlorococcus strains resistant to phage
Avrani, Proceedings of the National Academy of Sciences of the United States of America 2015 - “...in evolved strains. (A) PMM1209, (B) PMM0278, (C ) PMM0076, (D) PMM1124, and (E ) the PMM1200-PMM1205 gene cluster. The PMM0278 and PMM0076 genes are homologs....”
- “...(Regain, right block arrow). Mutations upstream of the PMM0076 gene indicate nucleotide substitutions. See Tables S2-S5 for the exact mutations. The number of...”
Mfl120 phosphomannomutase/phosphoglucomutase homolog from Mesoplasma florum L1
27% identity, 94% coverage
- Genome-scale metabolic modeling reveals key features of a minimal gene set
Lachance, Molecular systems biology 2021 - “...carrying promiscuous reactions (pink) responsible for maltose and mannose catabolism. 3D structures of candidates (Mfl499, Mfl120, and Mfl254; red) are superimposed to available structures in the Protein Data Bank (light blue) for which the suspected enzymatic activity is annotated. FATCAT P values are shown. The 173...”
- “...protein and the A chain of the phosphoglucose/phosphomannose isomerase of Pyrobaculum aerophilum (1tzbA; PaPGI/PMI), (C) Mfl120 protein and the X chain of the phosphomannomutase/phosphoglucomutase of Pseudomonas aeruginosa (1k2yX; PMM/PGM), and (D, E) Mfl121 and Mfl639 proteins and the A chain of the transaldolase of Thermotoga maritima...”
Pro0090 Phosphoglucomutase from Prochlorococcus marinus str. SS120
26% identity, 88% coverage
- Glucose uptake and its effect on gene expression in prochlorococcus
Gómez-Baena, PloS one 2008 - “...EC code Gene code in SS120 Hypothetical sugar transporter melB - Pro1404 Phosphoglucomutase pgm 5.4.2.2 Pro0090 Glucokinase glk 2.7.1.2 Pro1065 Glucose-6-phosphate isomerase pgi 5.3.1.9 Pro0946 Glucose-6-phosphate dehydrogenase zwf 1.1.1.49 Pro1124 6-phosphogluconolactonase nagB 3.1.1.31 Pro0844 6-phosphogluconate dehydrogenase gnd 1.1.1.44 Pro0843 Phosphoribulokinase prk 2.7.1.19 Pro0861 Pentose-5-phosphate-3-epimerase rpe 5.1.3.1...”
C7W88_RS11010 alpha-D-glucose phosphate-specific phosphoglucomutase from Novosphingobium sp. THN1
28% identity, 88% coverage
- Microcystin-LR Degradation and Gene Regulation of Microcystin-Degrading Novosphingobium sp. THN1 at Different Carbon Concentrations
Wang, Frontiers in microbiology 2019 - “...2.297 triosephosphate isomerase tpiA C7W88_RS12520 1.5082 1.6432 glycolysis/gluconeogenesis glucokinase glk C7W88_RS12365 2.3853 3.1357 phosphoglucomutase pgm C7W88_RS11010 0.78001 1.1774 glucose-6-phosphate isomerase pgi C7W88_RS11855 0.87915 1.302 triosephosphate isomerase tpiA C7W88_RS12520 1.5082 1.6432 phosphoglycerate kinase pgk C7W88_RS13175 1.8881 2.297 phosphoglycerate mutase gpmA C7W88_RS04095 2.1473 2.1183 enolase eno C7W88_RS14090 1.7147...”
- “...0.8111 glucose-6-phosphate isomerase pgi C7W88_RS11855 0.87915 1.302 ribose-phosphate pyrophosphokinase prsA C7W88_RS01250 2.4087 2.743 phosphoglucomutase pgm C7W88_RS11010 0.78001 1.1774 6-phosphogluconolactonase devB C7W88_RS12355 2.1998 2.9099 amino sugar and nucleotide sugar metabolism UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase wecC C7W88_RS02750 0.52148 0.51175 phosphoglucosamine mutase glmM C7W88_RS03760 0.61432 0.51499 fructokinase scrK C7W88_RS12310 2.1873...”
Cthe_1265 phospho-sugar mutase from Acetivibrio thermocellus ATCC 27405
Cthe_1265 alpha-phosphoglucomutase from Clostridium thermocellum ATCC 27405
24% identity, 88% coverage
- Utilization of Monosaccharides by Hungateiclostridium thermocellum ATCC 27405 through Adaptive Evolution
Ha-Tran, Microorganisms 2021 - “...extent when compared to the parent strain, GAs1. In contrast, in FAs8, only two genes (Cthe_1265 and Cthe_0946) exhibited a slightly upregulated pattern relative to FAs1. Therefore, transcriptomic profile alone cannot adequately explain the acquired phenotype of FAs8. Additional information from genome resequencing with genetic mutations...”
- Integrated omics analyses reveal the details of metabolic adaptation of Clostridium thermocellum to lignocellulose-derived growth inhibitors released during the deconstruction of switchgrass
Poudel, Biotechnology for biofuels 2017 - “...4. Glucose-1-phosphate is further converted to the glycolytic intermediate glucose-6-phosphate in the presence of phosphoglucomutase (Cthe_1265), whereas glucose converts to glucose-6-phosphate in presence of glucokinase, Cthe_0390, a member of cluster 4. Fig.3 Glycolytic pathway. All the enzymes shown in the pathways were detected in mass spectrometry...”
- “...Cellulosomes ; 2. Cellodextrin ABC transporters Cthe_1019, 1020, 1862; 3. Cellodextrin phosphorylase Cthe_2989; 4. Phosphoglucomutase Cthe_1265; 5. Glucokinase Cthe_0390; 6. Gluco - 6 - P - Isomerase Cthe_0217; 7. Phosphofructokinase Cthe_0347; 8. Fructose - bis - P - aldolase Cthe_0349, 0319; 9. Glyceraldehyde - 3 -...”
- Global gene expression patterns in Clostridium thermocellum as determined by microarray analysis of chemostat cultures on cellulose or cellobiose
Riederer, Applied and environmental microbiology 2011 - “...Cthe_1261 Cthe_0946 Cthe_2989 Cthe_2938 Cthe_1292 Cthe_0349 Cthe_1265 Cthe_1053 Cthe_2449 Cthe_1435 a b c Enolase Ferredoxin Acetaldehyde/CoA dehydrogenase...”
YG2_16120 phospho-sugar mutase from Tetragenococcus halophilus
26% identity, 87% coverage
THA_1027 phosphoglucomutase/phosphomannomutase family protein from Thermosipho africanus TCF52B
25% identity, 88% coverage
LOC110115522 phosphoglucomutase, cytoplasmic from Dendrobium catenatum
28% identity, 67% coverage
7pjcB / A0A1D8PSA9 The structure of candida albicans phosphoglucomutase with isothiazolone modification on cys359
26% identity, 91% coverage
- Ligand: ~{n}-(3-chloranyl-2-fluoranyl-phenyl)-3-sulfanyl-propanamide (7pjcB)
Q99ZH8 Phosphoglucomutase from Streptococcus pyogenes serotype M1
M5005_Spy_0938 phosphoglucomutase/phosphomannomutase from Streptococcus pyogenes MGAS5005
25% identity, 87% coverage
SAMCCGM7_Ch3149 alpha-D-glucose phosphate-specific phosphoglucomutase from Sinorhizobium americanum CCGM7
28% identity, 75% coverage
Ava_2367 Phosphoglucomutase/phosphomannomutase from Anabaena variabilis ATCC 29413
24% identity, 88% coverage
F6HFF7 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) from Vitis vinifera
27% identity, 62% coverage
- Root Proteomic Analysis of Two Grapevine Rootstock Genotypes Showing Different Susceptibility to Salt Stress
Prinsi, International journal of molecular sciences 2020 - “...Sucrose synthase (2) 10.91 235 D7SHY3 Betaine aldehyde dehydrogenase 1, chloroplastic (5, 16) 8.62 64 F6HFF7 Phosphoglucomutase, cytoplasmic 1 (4) 3.46 227 A5BF93 SuccinateCoA ligase [ADP-forming] subunit beta, mitochondrial (8) 3.44 152 F6HGZ9 Sucrose synthase (2) 3.11 133 D7T300 ATP synthase subunit O, mitochondrial (9) 3.06...”
- Differential proteomic analysis of grapevine leaves by iTRAQ reveals responses to heat stress and subsequent recovery
Liu, BMC plant biology 2014 - “...Fold change Bin Species Description HS RC F6I0H8 0.548 1.144 4.1 Gossypium hirsutum UDP-D-glucose pyrophosphorylase F6HFF7 0.931 1.93 4.2 Ricinus communis Phosphoglucomutase A5B118 1.356 0.481 4.7 Vitis vinifera Fructose-bisphosphate aldolase, FBA A5BX43 1.222 0.461 4.7 Vitis vinifera Fructose-bisphosphate aldolase, FBA, cytoplasmic isozyme 1-like F6GSG7 1.105 0.653...”
PGM2 / P37012 phosphoglucomutase-2 (EC 5.4.2.2) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 10 papers)
PGM2_YEAST / P37012 Phosphoglucomutase 2; PGM 2; D-glucose-1,6-diphosphate:D-glucose-1-phosphate phosphotransferase; Glucose phosphomutase 2; EC 5.4.2.2 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 11 papers)
NP_013823 phosphoglucomutase PGM2 from Saccharomyces cerevisiae S288C
YMR105C Pgm2p from Saccharomyces cerevisiae
26% identity, 89% coverage
- function: Major phosphoglucomutase isozyme that catalyzes the reversible isomerization of alpha-D-glucose 1-phosphate to alpha-D- glucose 6-phosphate (PubMed:1100398, PubMed:23103740, PubMed:4992300, PubMed:5784209). The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate (Probable). Constitutes about 80-90% of the phosphoglucomutase activity in the cell (PubMed:14264884, PubMed:5231755). Key enzyme in hexose metabolism. The forward reaction is an essential step in the energy metabolism of galactose since the product of the galactose pathway enzymes in yeast is glucose 1- phosphate. The reverse reaction is an essential step for biosynthesis when carbon sources other than galactose are the energy source because glucose 1-phosphate is the starting point for the synthesis of UDP- glucose, which acts as a precursor for the synthesis of oligosaccharides and trehalose (PubMed:14264884).
catalytic activity: alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate (RHEA:23536)
catalytic activity: O-phospho-L-seryl-[protein] + alpha-D-glucose 1-phosphate = alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] (RHEA:68748)
catalytic activity: alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] = O- phospho-L-seryl-[protein] + alpha-D-glucose 6-phosphate (RHEA:68752)
cofactor: Mg(2+) Zn(2+) (Binds 1 magnesium ion per subunit. Can also use Zn(2+) as cofactor.)
subunit: Monomer.
disruption phenotype: Blocks galactose utilization, but does not impair growth on glucose. - A framework for application of metabolic modeling in yeast to predict the effects of nsSNV in human orthologs
Dingerdissen, Biology direct 2014 - “...Q9NYY3 P32562 Q13907 P15496 O60942 Q01159 O43426 P50942 P49841 P38615 Q9UGP5 P25615 O95363 P08425 P36871 P37012 Q9BUP3 P40008 P34949 P29952 Q9UBZ9 P12689 P54098 P15801 Q7L211 P42840 Q9HBY8 P12688 Q9UJM8 P00175 P07741 P49435 P07902 P08431 Q8WUX2 P32656 P13716 P05373 Q9Y2L1 Q08162 Q14249 P08466 P48449 P38604 Q96C11 Q04585...”
- Lithium chloride sensitivity connects the activity of PEX11 and RIM20 to the translation of PGM2 and other mRNAs with structured 5'-UTRs.
Jagadeesan, Molecular and cellular biochemistry 2022 (PubMed)- GeneRIF: Lithium chloride sensitivity connects the activity of PEX11 and RIM20 to the translation of PGM2 and other mRNAs with structured 5'-UTRs.
- Enhancement of bioethanol production from Gracilaria verrucosa by Saccharomyces cerevisiae through the overexpression of SNR84 and PGM2.
Sukwong, Bioprocess and biosystems engineering 2019 (PubMed)- GeneRIF: The overexpression of both SNR84 and PGM2 increased the transcriptional levels of GAL and regulatory genes; however, the transcriptional levels of these genes were lower than those in S. cerevisiae adapted to high galactose concentrations.
- Molecular characterization reveals that YMR278w encoded protein is environmental stress response homologue of Saccharomyces cerevisiae PGM2.
Tiwari, Biochemical and biophysical research communications 2008 (PubMed)- GeneRIF: Based on the above results we suggest that YMR278w encodes phosphoglucomutase and not phosphoribomutase.
- Characterization of the Pneumocystis jirovecii and Pneumocystis murina phosphoglucomutases (Pgm2s): a potential target for Pneumocystis therapy
Kottom, Antimicrobial agents and chemotherapy 2024 (secret) - The regulatory mechanism of the yeast osmoresponse under different glucose concentrations
Shen, iScience 2023 - “...Tdh1-GFP 6P 15 YGR088W Ctt1-GFP 3B 8 YDR074W Tps2-GFP 2E 7 YOR173W Dcs2-GFP 5F 23 YMR105C Pgm2-GFP 3D 12 YHR008C Sod2-GFP 8G 11 YOR374W Ald4-GFP 4I 4 YDR368W Ypr1-GFP 6B 20 YPR160W Gph1-GFP 2M 3 YHR043C Dog2-GFP 7D 18 YOR185C Gsp2-GFP 11B 5 YFR053C Hxk1-GFP 4J...”
- The Role of Ancestral Duplicated Genes in Adaptation to Growth on Lactate, a Non-Fermentable Carbon Source for the Yeast Saccharomyces cerevisiae
Mattenberger, International journal of molecular sciences 2021 - “...or stress-response elements were Ctr1 (YPR124W), Gph3 (YPR160W), Gsy2 (YLR258W; WGD), Tma10 (YLR327C; WGD), Pgm2 (YMR105C; WGD), Opi10 (YOL032W), Gad1 (YMR250W; SSD), Fes1 (YBR101C), Rgi (YER067W; WGD), Btn2 (YGR142W; WGD), Rie1 (YGR250C), Tdh1 (YJL052W), Roq1 (YJL144W) and Mrs4 (YKR052C; WGD). 2.7. Metabolic Evolution of YPL Adapted...”
- RiboDoc: A Docker-based package for ribosome profiling analysis
François, Computational and structural biotechnology journal 2021 - “...[22] . The only gene strongly downregulated in the presence of OAZ-if was the PGM2 (YMR105c) gene, encoding the major phosphoglucomutase isoform involved in glycolysis, the pentose phosphate shunt, and the metabolism of glycogen, trehalose, and galactose [27] . In the absence of a transcriptome, we...”
- Transcriptional profiling reveals molecular basis and novel genetic targets for improved resistance to multiple fermentation inhibitors in Saccharomyces cerevisiae
Chen, Biotechnology for biofuels 2016 - “...YPL053C, YPR160W, YPR165W YEL040W, YFR053C, YGL156W, YGR043C, YGR256W, YJR096W , YLL026W , YLR286C , YML100W, YMR105C, YOR120W, YPR160W YBR001C, YBR105C, YCR005C, YDL055C, YER001W, YFL053W, YFR053C, YGL156W, YGL179C, YGR043C, YGR256W, YGR279C, YGR282C, YHR104W, YIL045W, YIL107C, YJL153C, YJR096W , YLL026W , YLR286C , YLR300W, YLR342W, YML070W, YML100W, YMR307W,...”
- “...YNL220W, YOL086C, YOR128C, YOR153W, YOR184W, YOR328W, YPL036W, YPL058C YCR021C , YDR502C, YGR043C, YGR256W, YKL151C, YLR249W, YMR105C, YOR128C, YPL036W YBL022C, YCR021C , YDL055C, YDR011W, YDR135C, YDR214W, YDR502C, YEL039C, YER043C, YFL037W, YGR043C, YGR209C, YGR256W, YGR281W, YKR080W, YLR180W, YMR120C, YNL220W, YOR153W, YOR328W, YPL058C Response to chemical (GO:0042221) YBL022C, YBR008C,...”
- Gleaning evolutionary insights from the genome sequence of a probiotic yeast Saccharomyces boulardii
Khatri, Gut pathogens 2013 - “...Suppressor of SHr3 deletion); srt1 (YMR101C, Cis-prenyltransferase); YMR102C; YMR103C; ypk2 (YMR104C, Yeast protein kinase); pgm2 (YMR105C, Phosphoglucomutase); yku80 (YMR106C, Yeast KU protein); spg4 (YMR107C, Stationary Phase gene). Future directions The genome of Sb offers an important starting point to glean insights into the probiotic effects of...”
- Adjustment of trehalose metabolism in wine Saccharomyces cerevisiae strains to modify ethanol yields
Rossouw, Applied and environmental microbiology 2013 - “...Y12258 Y15575 Y15599 PGM1 PGM2 ZWF1 TKL1 YKL127w YMR105c YHL012W YNL241c YPR074c Y14977 Y16545 Y10951 Y11971 Y15493 GUT1 GUT2 GPD1 GPD2 YHL032c YIL155c YDL022w...”
- Extracting regulatory modules from gene expression data by sequential pattern mining
Kim, BMC genomics 2011 - “...highly overlapped in genes but little in samples. More than half of the modules include YMR105C, YBR126C, and YFR053C, which are all related to carbohydrate metabolism as Phosphoglucomutase, Trehalose-6-Phosphate synthase, and Hexokinase I, respectively. However, the sample contexts are as diverse as oxidative stress,DNA damage, Nutrient...”
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BMEI1886 PHOSPHOGLUCOMUTASE from Brucella melitensis 16M
27% identity, 73% coverage
- Main functions and taxonomic distribution of virulence genes in Brucella melitensis 16 M
Brambila-Tapia, PloS one 2014 - “...[8] BMEI1204 ppx Exopolyphosphatase F/P 216 [8] , [24] BMEI1396 pmm Phosphomannomutase G 5 [7] BMEI1886 BMEI1886 Phosphoglucomutase G 304 [8] BMEI2031 ptsH Phosphocarrier protein HPr G 273 [8] BMEII0485 galcD D-galactarate dehydratase G 185 [7] BMEII0591 BMEII0591 Sugar transport system permease G 119 [7] BMEII0624...”
- Analyses of Brucella pathogenesis, host immunity, and vaccine targets using systems biology and bioinformatics
He, Frontiers in cellular and infection microbiology 2012 - “...HeLa 14979322 53 ndvB BMEI1837 Mice, HeLa 14979322 54 pgi BMEI1636 Macrophages 10678941 55 pgm BMEI1886 Mice 12525425 56 pmm BMEI1396 Mice, macrophages, HeLa 14979322 57 rbsK BMEII0089 Macrophages 14979322 58 ugpA BMEII0624 Mice 14638795 59 xfp BMEII0881 Mice, macrophages, HeLa 14979322 60 zwf BMEII0513 HeLa,...”
- Ontology-based Brucella vaccine literature indexing and systematic analysis of gene-vaccine association network
Hur, BMC immunology 2011 - “...V C (9.97) BMEII0145 xylG D-xylose ABC transporter, ATP-binding protein 6 3 (2) CM (7.88) BMEI1886 pgm phosphoglucomutase 9 2 (1) V C (8.96) BMEII0251 glk glucokinase 5 1 (1) C (9.97) Intracellular trafficking, secretion, and vesicular transport BMEI1077 yajC preprotein translocase, YajC subunit 6 1...”
- Brucellosis vaccines: assessment of Brucella melitensis lipopolysaccharide rough mutants defective in core and O-polysaccharide synthesis and export
González, PloS one 2008 - “...altered growth rates, we obtained the corresponding growth curves. Mutants in BMEI1415 ( wzm ), BMEI1886 (p gm ) and BMEI1326 ( wa** ) were retarded with respect to the parental strain whereas BMEII0899 ( manB core ) grew faster ( Figure S1 ). 10.1371/journal.pone.0002760.t001 Table...”
- “...wbkF Undecaprenyl-glycosyltransferase BMEI1427 H38 (2) Transposon and in frame deletion O-PS synthesis (R1) wbkD Epimerase/dehydratase BMEI1886 16M (1) Transposon Core synthesis (R2) pgm Phosphoglucomutase BMEII0899 H38 (1) Transposon Core synthesis (R3) manB core Phosphomannomutase 1 16M, B. melitensis 16M Nal R ; H38, B. melitensis H38Nal...”
SAK_1155 phosphoglucomutase/phosphomannomutase family protein from Streptococcus agalactiae A909
gbs1100 Unknown from Streptococcus agalactiae NEM316
25% identity, 88% coverage
BCE_5058 phosphoglucomutase/phosphomannomutase family protein from Bacillus cereus ATCC 10987
26% identity, 87% coverage
- A genome-scale metabolic reconstruction of Mycoplasma genitalium, iPS189
Suthers, PLoS computational biology 2009 - “...1-deoxy-D-xylulose 5-phosphate synthase DXPS MG066 B. subtilis BSU24270 2E-09 2E-10 Phosphoglucomutase PGMT MG053 B. cereus BCE_5058 2E-67 2E-67 glutamine-N5 methyltransferase GLNMT MG259 E. coli b1212 1E-10 6E-11 a Encodes the phosphocarrier protein. The phosphoenolpyruvate-protein phosphotransferase component (MG429) was already included in the model. b Forward referes...”
SMc03925 PROBABLE PHOSPHOGLUCOMUTASE (GLUCOSE PHOSPHOMUTASE) PROTEIN from Sinorhizobium meliloti 1021
Q92M12 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) from Rhizobium meliloti (strain 1021)
28% identity, 67% coverage
LSEI_0949 phospho-sugar mutase from Lacticaseibacillus paracasei ATCC 334
LSEI_0949 Phosphomannomutase from Lactobacillus casei ATCC 334
26% identity, 86% coverage
- Regulatory Mechanisms of L-Lactic Acid and Taste Substances in Chinese Acid Rice Soup (Rice-Acid) Fermented With a Lacticaseibacillus paracasei and Kluyveromyces marxianus
Liu, Frontiers in microbiology 2021 - “...0.960 ) in fermented rice-acid. The expression levels of the two genes of LSEI_0630 and LSEI_0949 had a significant and positive correlation with the concentrations of acetic acid, succinic acid, and citric acid. The expression levels of the gene LSEI_2477 had a significant and negative correlation...”
- “...in the group of the single inoculation of L. paracasei . The genes encoding phosphoglucomutase (LSEI_0949), ribonucleoside-triphosphate reductase (LSEI_2287), and the gene (LSEI_2229) were up-regulated and the genes encoding adenine phosphoribosyltransferase (LSEI_1557), phosphoribosylamine-glycine ligase (LSEI_1746), DNA-directed RNA polymerase subunit alpha (LSEI_2477) and DNA-directed RNA polymerase subunit...”
PAB1666 PHOSPHO-SUGAR MUTASE from Pyrococcus abyssi GE5
27% identity, 92% coverage
BAS4790 phosphoglucomutase/phosphomannomutase family protein from Bacillus anthracis str. Sterne
26% identity, 87% coverage
BC_4919 phospho-sugar mutase from Bacillus cereus ATCC 14579
26% identity, 87% coverage
- Proteomic evidences for rex regulation of metabolism in toxin-producing Bacillus cereus ATCC 14579
Laouami, PloS one 2014 - “...[40] . In contrast, anaerobically grown rex cells sustain a higher level of phosphoglucomutase (Pgm; BC_4919) than the wild-type cells (log 2 =0.6; p -value=0.036) and thus, could sustain a higher carbon flux through gluconeogenesis than glycolysis ( Fig. 1 ). As for Pgm, the malate...”
- “...could involve interplay of transcriptional and/or post-transcriptional regulation of key glycolytic enzymes (such as Pgm, BC_4919 under anaerobiosis and PK, BC_4599 under aerobiosis) and post-translational regulation of lactate dehydrogenase. Evidently, further intensive work is required to unravel the complexity of the regulatory network involving Rex. Finally,...”
Q9M4G4 Phosphoglucomutase, cytoplasmic from Solanum tuberosum
29% identity, 67% coverage
- Allergen false-detection using official bioinformatic algorithms.
Herman, GM crops & food 2020 - “...P29518 P11402 1 Q3HRY7 1 B6SL97 P13788 P37829 Q01526 O20252 1 Q9M4G5 25 B4FUH2 P17353 Q9M4G4 B4FPL1 P22418 C6F3B7 2 B6UGJ4 A1XIR6 P33191 7 1 5 P55240 Q8RU73 P37830 Q84J79 P09559 K7WJT8 K7UNW7 P05435 Q948Z8 B6T7B2 P06508 P23509 P93804 Q02254 B4F7S2 Q02060 Rice Tomato Wheat Q6Z782...”
F8U875 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) from Amorphophallus konjac
26% identity, 73% coverage
PGM1 / P33401 phosphoglucomutase-1 (EC 5.4.2.2) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 6 papers)
PGM1_YEAST / P33401 Phosphoglucomutase 1; PGM 1; Glucose phosphomutase 1; EC 5.4.2.2 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 6 papers)
NP_012795 phosphoglucomutase PGM1 from Saccharomyces cerevisiae S288C
NP_012795, YKL127W Pgm1p from Saccharomyces cerevisiae
27% identity, 86% coverage
- function: Minor phosphoglucomutase isozyme that catalyzes the reversible interconversion of alpha-D-glucose 1-phosphate and alpha-D- glucose 6-phosphate (PubMed:23103740, PubMed:5784209). The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate (Probable). Constitutes about 10-20% of the phosphoglucomutase activity in the cell (PubMed:14264884, PubMed:5231755). Key enzyme in hexose metabolism. The forward reaction is an essential step in the energy metabolism of galactose since the product of the galactose pathway enzymes in yeast is glucose 1-phosphate. The reverse reaction is an essential step for biosynthesis when carbon sources other than galactose are the energy source because glucose 1-phosphate is the starting point for the synthesis of UDP-glucose, which acts as a precursor for the synthesis of oligosaccharides and trehalose (PubMed:14264884).
catalytic activity: alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate (RHEA:23536)
catalytic activity: O-phospho-L-seryl-[protein] + alpha-D-glucose 1-phosphate = alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] (RHEA:68748)
catalytic activity: alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] = O- phospho-L-seryl-[protein] + alpha-D-glucose 6-phosphate (RHEA:68752)
cofactor: Mg(2+) (Binds 1 Mg(2+) ion per subunit.)
subunit: Monomer. - Increased phosphoglucomutase activity suppresses the galactose growth defect associated with elevated levels of Ras signaling in S. cerevisiae.
Howard, Current genetics 2006 (PubMed)- GeneRIF: elevated levels of phosphoglucomutase activity allow for the more efficient utilization of the limiting levels of glucose-1-phosphate that are present in the RAS2(val19) mutant.
- The RNA-binding protein repertoire of Arabidopsis thaliana.
Marondedze, Scientific reports 2016 (no snippet) - Plastidial Phosphoglucomutase (pPGM) Overexpression Increases the Starch Content of Transgenic Sweet Potato Storage Roots
Wang, Genes 2022 - “...At1g23190; PscPGM: P. sativum , AJ250769; ZmcPGM: Zea mays , U89341; ScPGM: Saccharomyces cerevisiae , NP_012795. Homology in amino acids is shaded with dark blue (homology = 100%), lightblue (homology 75%) or grey (homology 50%). Figure 2 Phylogenetic and gene structure analyses of IbpPGM and PGMs...”
- “...Oryza sativa , XP_015632142; Sorghum bicolor , XP_002466576; Z. mays , U89341; S. cerevisiae , NP_012795. Figure 3 Expression patterns of IbpPGM. ( a ) Expression of IbpPGM in different tissues of Xu 781 sweet potato. L, leaves, S, stems, P, petioles, SR, storage roots, FR,...”
- Gleaning evolutionary insights from the genome sequence of a probiotic yeast Saccharomyces boulardii
Khatri, Gut pathogens 2013 - “...Reduced Mating A); she2 (YKL130C, Swi5p-dependent HO Expression); myo3 (YKL129C, Myosin); pmu1 (YKL128C, Phosphomutase); pgm1 (YKL127W, Phosphoglucomutase); ypk1 (YKL126W, Yeast protein kinase); rrn3 (YKL125W, Regulation of RNA Polymerase); ssh4 (YKL124W, Suppressor of SHr3 deletion); srt1 (YMR101C, Cis-prenyltransferase); YMR102C; YMR103C; ypk2 (YMR104C, Yeast protein kinase); pgm2 (YMR105C,...”
- Adjustment of trehalose metabolism in wine Saccharomyces cerevisiae strains to modify ethanol yields
Rossouw, Applied and environmental microbiology 2013 - “...Y16388 Y12258 Y15575 Y15599 PGM1 PGM2 ZWF1 TKL1 YKL127w YMR105c YHL012W YNL241c YPR074c Y14977 Y16545 Y10951 Y11971 Y15493 GUT1 GUT2 GPD1 GPD2 YHL032c YIL155c...”
- Conservation of nucleosome positions in duplicated and orthologous gene pairs
Nishida, TheScientificWorldJournal 2012 - “...0.956085616 0.955561088 134139 chr11 YKL165C 0.960609423 0.966621061 140696 chr11 YKL157W 0.95635277 0.9813363 154996 + chr11 YKL127W 0.955985661 0.982208081 203185 + chr11 YKL125W 0.976449752 0.960074911 207891 + chr11 YKL113C 0.971544612 0.954413703 225519 chr11 YKL065C 0.96005541 0.969818928 316701 chr11 YKL064W 0.974644257 0.972632809 317408 + chr11 YKL059C 0.957153957 0.961241915...”
- “...YDR322W AFUA_5G12810 0.002517201 YNR015W AFUA_3G08390 0.013154917 YBR251W AFUA_5G11540 0.01637247 YHL028W AFUA_5G09020 0.020657813 YPL146C AFUA_2G05550 0.023787247 YKL127W AFUA_3G11830 0.026619404 YJR160C AFUA_2G10910 0.029508087 YIR038C AFUA_1G17010 0.030714781 YDL247W AFUA_2G10910 0.033905332 YBR204C AFUA_1G03540 0.038361835 YJR010W AFUA_3G06530 0.038908707 YMR210W AFUA_6G04640 0.046477426 YPR187W AFUA_1G05160 0.048502572 YDR037W AFUA_6G07640 0.052027721 YIL134W AFUA_6G05170 0.053118026 YLR286C...”
- Improving the iMM904 S. cerevisiae metabolic model using essentiality and synthetic lethality data
Zomorrodi, BMC systems biology 2010 - “...such an inconsistency in both minimal and YP media. This SLG pertains to genes PGM1 (YKL127W) and PGM2 (YMR105C) that code for isozymes of reaction PGMT (phosphoglucomutase) involved in glycolysis/gluconeogenesis. The simultaneous deletion of PGM1 and PGM2 is lethal based on the i MM904 model since...”
- Preferential protection of protein interaction network hubs in yeast: evolved functionality of genetic redundancy
Kafri, Proceedings of the National Academy of Sciences of the United States of America 2008 - “...YOR136W YNL037C YDR227C YMR105C YOR047C on galactose YKL127W YDR293C YDL160C YIL035C YOR061W YIL074C w/o serine YNL055C YER081W YIL114C YKR028W YJLO98W YDL047W...”
- “...YMR105C) and their respective paralogs (YIL074C and YKL127W, respectively), SSL interactions were obtained only in specific growth conditions (lack of serine...”
- What properties characterize the hub proteins of the protein-protein interaction network of Saccharomyces cerevisiae?
Ekman, Genome biology 2006 - “...party hubs (green nodes) and date hubs (yellow nodes); an example. a) Non-hub protein PGM1 (YKL127W, large node) is the metabolic enzyme phosphoglucomutase, which consists of four well characterized domains associated with phosphoglucomutase activity. PGM1 is only connected to two other proteins, which are not hubs....”
E5SQZ6 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) from Trichinella spiralis
25% identity, 77% coverage
- Quantitative label-free proteomic analysis of excretory-secretory proteins in different developmental stages of Trichinella spiralis
Liu, Veterinary research 2024 - “...the KEGG pathway annotation. A pathway map of glycolysis/gluconeogenesis revealed that several related proteins, phosphoglucomutase (E5SQZ6), fructose-bisphosphate aldolase (A0A0V1AX39), triosephosphate isomerase (E5SS61), phosphoglycerate kinase (A0A0V1B8E2), enolase (A0A0V1BT87), and phosphoenolpyruvate carboxykinase (A0A0V1AZ55), were significantly upregulated in IIL-ES compared with ML-ES ( P <0.05) (Figure 9 A). However,...”
- “...( P <0.05) (Figure 9 B). For Ad 6 dpi-ES, the expression of the proteins E5SQZ6, A0A0V1AX39, E5SS61, A0A0V1BT87, and A0A0V1AZ55 was also significantly downregulated ( P <0.05) (Figure 9 C). However, the glycolysis/gluconeogenesis pathway was not significantly different between PA 30h-ES and Ad 3 dpi-ES....”
Q2YPS4 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) from Brucella abortus (strain 2308)
BAB1_0055 Phosphoglucomutase/phosphomannomutase:Phosphoglu c omutase/phosphomannomutase C terminal:Phosphoglucomutase/phosphomannomutase ... from Brucella melitensis biovar Abortus 2308
BR0058 phosphoglucomutase from Brucella suis 1330
BAW_10055 alpha-D-glucose phosphate-specific phosphoglucomutase from Brucella abortus
27% identity, 76% coverage
- Lysine Acylation Modification Landscape of Brucella abortus Proteome and its Virulent Proteins
Zhang, Frontiers in cell and developmental biology 2022 - “...5 3 3 lpxE BAB1_0761 wboA BAB1_0999 Q2YQ89 5 14 4 4 5 pgm BAB1_0055 Q2YPS4 19 18 15 14 9 wbpZ manAoAg BAB1_0563 manCoAg BAB1_0561 Q2YMQ9 4 7 5 4 2 pmm BAB1_0560 wbkA BAB1_0553 Q2YMN5 2 1 0 0 0 gmd BAB1_0545 Q2YMP3 8...”
- Evaluation and Differential Diagnosis of a Genetic Marked Brucella Vaccine A19ΔvirB12 for Cattle
Yang, Frontiers in immunology 2021 - “...subunit II 0.158 CytoplasmicMembrane C bacA Q2YMA1 Bacteroid development protein BacA 0.229 CytoplasmicMembrane I pgm Q2YPS4 Phosphoglucomutase/phosphomannomutase:Phosphogluc omutase/phosphomannomutase C terminal:Phosphoglucomutase/phosphomannomutase 0.246 Cytoplasmic G leuA Q2YRT1 2-isopropylmalate synthase 0.444 Cytoplasmic E recA Q2YRU7 Protein RecA 0.486 Cytoplasmic L ureG2 Q2YQD6 Urease accessory protein UreG 2 0.193 Cytoplasmic...”
- Brucella MucR acts as an H-NS-like protein to silence virulence genes and structure the nucleoid
Barton, mBio 2023 - “...T4SS effectorinhibits host cell apoptosis 89 bpe275 BAB1_1275 T4SS effectorfunction unknown 482 LPS biosynthesis pgm BAB1_0055 Core biosynthesis 278 wbkD BAB1_0534 O-chain synthesis 488 wbkF BAB1_0535 O-chain synthesis 318 wbkC BAB1_0540 O-chain synthesis 6,590 wzt / rfbB BAB1_0542 O-chain synthesis 47 wzm / rfbD BAB1_0543 O-chain...”
- Lysine Acylation Modification Landscape of Brucella abortus Proteome and its Virulent Proteins
Zhang, Frontiers in cell and developmental biology 2022 - “...4 5 3 3 lpxE BAB1_0761 wboA BAB1_0999 Q2YQ89 5 14 4 4 5 pgm BAB1_0055 Q2YPS4 19 18 15 14 9 wbpZ manAoAg BAB1_0563 manCoAg BAB1_0561 Q2YMQ9 4 7 5 4 2 pmm BAB1_0560 wbkA BAB1_0553 Q2YMN5 2 1 0 0 0 gmd BAB1_0545 Q2YMP3...”
- The regulon of Brucella abortus two-component system BvrR/BvrS reveals the coordination of metabolic pathways required for intracellular life
Rivas-Solano, PloS one 2022 - “...BAB1_1172 ND phosphatidate cytidylyltransferase 3 BAW_11911 BAB1_1994 ND 1-acyl-sn-glycerol-3-phosphate acyltransferase UDP-alpha-D-glucose biosynthesis 0.009982516 1 BAW_10055 BAB1_0055 pgm Phosphoglucomutase catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate 1 BAW_10301 BAB1_0316 pgi Glucose-6-phosphate isomerase 1 BAW_11625 BAB1_1702 glmM Phosphoglucosamine mutase, catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate....”
- Periplasmic protein EipA determines envelope stress resistance and virulence in Brucella abortus
Herrou, Molecular microbiology 2019 - “...by a black lightning bolt. B. abortus genes that are synthetically lethal with eipA are: bab1_0055 ( pgm : phosphoglucomutase), bab1_0534 ( wbkD/capD : epimerase/dehydratase), and bab1_0535 ( wbkF/wecA : undecaprenyl-glycosyltransferase), bab1_0542 ( wzt/rfbE : ATP-binding protein, O-antigen export), bab1_0543 ( wzm/rfbD : permease, O-antigen export),...”
- The Brucella abortus general stress response system regulates chronic mammalian infection and is controlled by phosphorylation and proteolysis
Kim, The Journal of biological chemistry 2013 - “...material. Locus ID BAB1_1775 BAB2_0505 BAB1_0055 BAB2_0727 BAB2_0728 BAB2_0726 BAB1_1378 BAB1_1376 BAB1_1377 BAB1_1380 BAB1_1381 BAB1_1382 BAB1_1383...”
- “...-3.9 -3.6 -3.6 -3.4 -3.3 -3.2 -3.1 BAB1_0055 BAB2_0759 BAB2_0727 BAB2_0728 BAB1_2064 BAB1_1471 BAB1_0643 BAB2_0863 BAB1_1217 BAB2_0726 BAB1_0981 BAB2_0449...”
- Intracellular adaptation of Brucella abortus
Lamontagne, Journal of proteome research 2009 - “...approached pre-infection levels at 20 and 44 hours post infection, while others like the Pmg (BAB1_0055), which supplies sugar substrates for the O chain polysaccharide synthesis 35 , increased early and remained elevated throughout the infection period. It has been proposed that Omp1 is involved in...”
- “...55 BAB2_0699 Transporters Trs-ABC oligopeptide 55 BAB1_1176 LPS synthesis Omp1 56 BAB2_0700 Transporters AgpA 56 BAB1_0055 LPS synthesis Pgm 57 BAB1_1685 Transporters HlyD-like 57 BAB2_0371 Lipid metabolism GDPH 58 BAB1_1226 Transporters OmpA 58 BAB1_0925 Lipid metabolism BccP 59 BAB2_0282 Transporters Trs-ABC branched amino acid 59 BAB1_1109...”
- The Complete Genome of Brucella Suis 019 Provides Insights on Cross-Species Infection
Wang, Genes 2016 - “...1151787 1153301 5-carboxy-2-hydroxymuconate semialdehyde dehydrogenase BRA1162 2 1162206 1162598 chr2_1076 1151325 1151717 5-carboxymethyl-2-hydroxymuconate delta isomerase BR0058 1 64824 66455 chr1_179 820216 821847 phosphoglucomutase BR0510 1 509856 511724 chr1_359 374961 376829 epimerase/dehydratase, putative BR0511 1 511711 512718 chr1_358 373967 374974 glycosyl transferase, group 4 family protein BR0517...”
- “...have been indicated as being important in producing smoothness. The disruption of 13 genes, Pgm (BR0058), WbkD (BR0510), WbkF (BR0511), Wzm (BR0520), Per (BR0521), Gmd (BR0522), WbkA (BR0529), ManB (BR0537), WbkE (BR0540), Wa** (BR0615), WboA (BR0981), WboB (BR0982) and ManBcore (BRA0348), resulted in a rough phenotype...”
- Identification and isolation of Brucella suis virulence genes involved in resistance to the human innate immune system
Liautard, Infection and immunity 2007 - “...these functions, a phosphoglucomutase gene (BR0058; http://helab.bioinformatics.med.umich.edu/) and a phosphomanomutase gene (BR0537). Inactivation of one of...”
- “...while the LPS depends on the other pgm gene (BR0058). This hypothesis is supported by the observation that BLAST analysis of organisms outside the genus...”
- The regulon of Brucella abortus two-component system BvrR/BvrS reveals the coordination of metabolic pathways required for intracellular life
Rivas-Solano, PloS one 2022 - “...BAW_11116 BAB1_1172 ND phosphatidate cytidylyltransferase 3 BAW_11911 BAB1_1994 ND 1-acyl-sn-glycerol-3-phosphate acyltransferase UDP-alpha-D-glucose biosynthesis 0.009982516 1 BAW_10055 BAB1_0055 pgm Phosphoglucomutase catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate 1 BAW_10301 BAB1_0316 pgi Glucose-6-phosphate isomerase 1 BAW_11625 BAB1_1702 glmM Phosphoglucosamine mutase, catalyzes the conversion of glucosamine-6-phosphate to...”
V4W5U2 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) from Citrus clementina
28% identity, 66% coverage
- Membrane Transporters in Citrus clementina Fruit Juice-Derived Nanovesicles
Stanly, International journal of molecular sciences 2019 - “...Elongation factor 500 Y V4T1U7 Uncharacterized protein 47.1 6.0 898.2 COG0446 Monodehydroascorbate reductase 112 Y V4W5U2 Uncharacterized protein 63.3 5.5 696.8 COG0033 Phosphoglucomutase 217 Y V4RUA3 Alpha-1,4 glucan phosphorylase 95.2 7.0 780.2 COG0058 Phosphorylase 297 Y V4TVW5 Sucrose synthase 92.6 6.0 660.8 COG0438 Sucrose-cleaving enzyme 154...”
CMU_003300 phosphoglucomutase-1 protein, putative from Cryptosporidium muris RN66
25% identity, 89% coverage
pgcA / P18159 α-phosphoglucomutase (EC 5.4.2.2) from Bacillus subtilis (strain 168) (see paper)
PGCA_BACSU / P18159 Phosphoglucomutase; PGM; Alpha-phosphoglucomutase; Glucose phosphomutase; EC 5.4.2.2 from Bacillus subtilis (strain 168) (see 2 papers)
BSU09310 alpha-phosphoglucomutase from Bacillus subtilis subsp. subtilis str. 168
NP_388812 alpha-phosphoglucomutase from Bacillus subtilis subsp. subtilis str. 168
26% identity, 82% coverage
- function: Catalyzes the interconversion between glucose-6-phosphate and alpha-glucose-1-phosphate. This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in B.subtilis membrane, which is also used as a membrane anchor for lipoteichoic acid (LTA). Has a role in the biosynthesis of all phosphate-containing envelope polymers, since glucose-1-phosphate is the precursor of UDP-glucose, which serves as a glucosyl donor not only for the biosynthesis of LTA but also for wall teichoic acids (WTAs). Is required for biofilm formation. This is likely due to another role of UDP-glucose, which might also act as a metabolic signal regulating biofilm formation or may be involved in some unknown biosynthetic pathway essential for biofilm formation, e.g. the synthesis of an exopolysaccharide.
catalytic activity: alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate (RHEA:23536)
cofactor: Mg(2+) (Binds 1 Mg(2+) ion per subunit.) - Kinetic Modeling and Meta-Analysis of the Bacillus subtilis SigB Regulon during Spore Germination and Outgrowth
Vohradsky, Microorganisms 2021 - “...2.2 . Gene CLASS Transcription Verified TNX Spacer Length Motifs 35 Spacer 10 pgcA (yhxB,gtaC,gtaE) BSU09310 I 1 1 16 35, 10 CGTTTA TTTTTTGATATCAATT GGGTAA GAACATATAAAGA yjlB BSU12270 I 1 1 15 35, 10 TGTTTG GCGAACCGCTATATG TGGAAG ACAAAAAAGGGAG nhaX (yheK) BSU09690 I 1 1 15 35,...”
- The Blueprint of a Minimal Cell: MiniBacillus
Reuß, Microbiology and molecular biology reviews : MMBR 2016 - “...Yes 3.6.3.40 tagG BSU35710 Yes tagU BSU35650 No BSU06720 BSU09310 BSU35670 Yes No No ltaS ugtP BSU07710 BSU21920 No No Coordination Divisome divIC BSU00620 Yes...”
- Inactivation of the phosphoglucomutase gene pgm in Corynebacterium glutamicum affects cell shape and glycogen metabolism
Seibold, Bioscience reports 2013 - “...Q8NMN0 cg2800 ( pgm ); E. coli P36938 b0688 ( pgm ); B. subtilis P18159 bsu09310 ( pgcA ); Pseudomonas aeruginosa P26276 pa5322 ( algC ). RESULTS Pgm activity and glycogen content in C. glutamicum As Pgm probably acts both as anabolic (e.g. for glycogen synthesis)...”
- Encapsulated in silica: genome, proteome and physiology of the thermophilic bacterium Anoxybacillus flavithermus WK1
Saw, Genome biology 2008 - “...Functional annotation Ortholog COG number abrB BSU00370 Transcriptional regulator Aflv_0031 COG2002 pgcA ( yhxB ) BSU09310 Alpha-phosphoglucomutase Aflv_2333 COG1109 sipW BSU24630 Signal peptidase - COG0681 yqxM BSU24640 Biofilm formation protein - - ecsB BSU10050 ABC transporter subunit Aflv_2284 COG4473 yqeK BSU25630 HD-superfamily hydrolase Aflv_0816 COG1713 ylbF...”
- Bacillus subtilis PgcA moonlights as a phosphoglucosamine mutase in support of peptidoglycan synthesis.
Patel, PLoS genetics 2019 - GeneRIF: Study presents evidence that B. subtilis PgcA possesses activity as a phosphoglucosamine mutase that contributes to peptidoglycan biosynthesis. This activity was made genetically apparent by the synthetic lethality of pgcA with glmR, a positive regulator of amino sugar biosynthesis, which can be specifically suppressed by overproduction of GlmM.
- Bacillus subtilis alpha-phosphoglucomutase is required for normal cell morphology and biofilm formation.
Lazarevic, Applied and environmental microbiology 2005 - GeneRIF: evidence presented that alpha-phosphoglucomutase [pcgA] deficiency correlates with altered cell morphology and impaired biofilm formation [PcgA]
- Inactivation of the phosphoglucomutase gene pgm in Corynebacterium glutamicum affects cell shape and glycogen metabolism
Seibold, Bioscience reports 2013 - “...), Q8NMN0 cg2800 ( pgm ); E. coli P36938 b0688 ( pgm ); B. subtilis P18159 bsu09310 ( pgcA ); Pseudomonas aeruginosa P26276 pa5322 ( algC ). RESULTS Pgm activity and glycogen content in C. glutamicum As Pgm probably acts both as anabolic (e.g. for glycogen...”
- Requirement for phosphoglucomutase in exopolysaccharide biosynthesis in glucose- and lactose-utilizing Streptococcus thermophilus
Levander, Applied and environmental microbiology 2001 - “...A. xylinum, P38569; Pgm E. coli, P36938; YhxB, P18159; Pgm S. pneumoniae, Q9RP94. Downloaded from http://aem.asm.org/ on February 19, 2017 by University of...”
A0A251S377 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) from Helianthus annuus
28% identity, 67% coverage
T303_05140 phospho-sugar mutase from Streptococcus thermophilus ASCC 1275
26% identity, 86% coverage
- Proteomic analysis reveals potential factors associated with enhanced EPS production in Streptococcus thermophilus ASCC 1275
Padmanabhan, Scientific reports 2020 - “...are indicated by the numbers: (1) T303_09510 -fructofuranosidase, (2) T303_07865 -Galactosidase, (3) T303_04850 Glucokinase, (4) T303_05140 Phosphoglucomutase, (5) T303_00105 UDP-glucose pyrophosphorylase, (6) T303_07880 UDP-glucose 4-epimerase, (7) T303_06690 UDP-galactose-4-epimerase, (8) T303_07885 Galactose-1-phosphate uridylyltransferase, (9) T303_07875 Galactose mutarotase, (10) T303_07890 Galactokinase, (11) T303_09500 Fructokinase, (12) T303_06845 6-phosphofructokinase, (13)...”
- “...a non-significant up-regulation was observed for UDP-glucose pyrophosphorylase (T303_00105), glucokinase (T303_04850), phosphoglucosamine mutase (T303_07195), phosphoglucomutase (T303_05140), phosphoglucose isomerase (T303_02195) and UDP-galactose 4 epimerase (T303_06690). Lactose media showed up-regulation of most of the proteins involved in nucleotide sugar formation. Proteins up-regulated in lactose media include 6-phosphofructokinase (T303_03155),...”
- Transcriptomic Insights Into the Growth Phase- and Sugar-Associated Changes in the Exopolysaccharide Production of a High EPS-Producing Streptococcus thermophilus ASCC 1275
Padmanabhan, Frontiers in microbiology 2018 - “...In M17-G at 5 h, the genes responsible for the formation of glucose-1-phosphate (Glu-1P) phosphoglucomutase (T303_05140), glycogen phosphorylase (T303_06080) and glycogen debranching proteins (T303_07940, T303_07950) were found to be significantly up-regulated. One of the genes in Leloir pathway (T303_07880) that is responsible for UPD-glucose and UDP-galactose...”
- “...three selected sugars, glucose, sucrose and lactose. Gene annotations:T303_09510 p-fructofuranosidase, T303_07865 p -galactosidase, T303_04850 glucokinase. T303_05140 phosphoglucomutase, T303_00105 UDP-glucose pyrophosphorylase, T303_07880 UDP-glucose 4-epinierase, T303_06690 UDP-galactose-4-epimerase, T303_07885 Galactose-1-phosphate uridylyltransferase, T303_07875 Galactose mutarotase, T303_07890 Galactokinase, T303_09500 Fructokinase, T303_06845 6-phosphofructokinase, T303_02195 Phosphoglucoseisomerase, T303_05515 glucosamine-fructose-6-phosphate aminotransferase, T303_07195 Phosphoglucosamine mutase, T303_03955...”
pgmA / CAB96418.1 phosphoglucomutase from Streptococcus thermophilus (see paper)
26% identity, 86% coverage
cgd2_3270 phosphoglucomutase, tandemly duplicated gene from Cryptosporidium parvum Iowa II
24% identity, 55% coverage
- Implication of Potential Differential Roles of the Two Phosphoglucomutase Isoforms in the Protozoan Parasite Cryptosporidium parvum
Nie, Pathogens (Basel, Switzerland) 2021 - “...In C. parvum , the two PGM isoforms were encoded at the loci cgd2_3260 and cgd2_3270 and their predicted ORFs (1707 and 2013 bp, respectively) were separated by a 210-base intergenic space ( Figure 1 B). Based on NCBIs conserved domain database (CDD) ( https://www.ncbi.nlm.nih.gov/cdd )...”
- “...corresponding 5-phosphopentoses), we named the two C. parvum PGM isoforms as CpPGM1A (cgd2_3260) and CpPGM1B (cgd2_3270) to clarify that they were PGM1 subfamily enzymes. Based a common practice in the field, CpPGM1A and CpPGM1B in italics were used for gene names, and CpPGM1A and CpPGM1B in...”
- Two Phosphoglucomutase Paralogs Facilitate Ionophore-Triggered Secretion of the Toxoplasma Micronemes
Saha, mSphere 2017 - “...[ PVX_094845 ], Gregarina niphandrodes PGM1 (GnPGM1) [ GNI_111250 ], Cryptosporidium parvum PGM1.1 (CpPGM1.1) [ cgd2_3270 ] and CpPGM1.2 [ cgd2_3260 ], Cryptosporidium muris PGM1.1 (CmPGM1.1) [ CMU_003300 ] and CmPGM1.2 [ CMU_003310 ], Cryptosporidium hominis PGM1 (ChPGM1) [ Chro.20343 ], Chromera velia PGM1 (CvPGM1) [...”
KLMA_30099 phosphoglucomutase-2 from Kluyveromyces marxianus DMKU3-1042
26% identity, 87% coverage
MSC_0829 phosphoglucomutase or phosphomannomutase from Mycoplasma mycoides subsp. mycoides SC str. PG1
26% identity, 90% coverage
- Mycoplasma agalactiae Secretion of β-(1→6)-Glucan, a Rare Polysaccharide in Prokaryotes, Is Governed by High-Frequency Phase Variation
Gaurivaud, Applied and environmental microbiology 2016 - “...MCCP01_0082 ND ND MCCP01_0081 (524 aa/7 TMDs) MSC_0829 MSC_0110, MSC_0990 MSC_0971, MSC_0978 MSC_0984 MSC_0108 (449 aa/4 TMDs) Pgm (Glc-6PGlc-1P) GalU...”
- “...agalactiae genome tested (similarity of 55% with MSC_0829 and MSC_0110, respectively), but no sequence similarity was evidenced for phosphotransferase system...”
- Characterization of free exopolysaccharides secreted by Mycoplasma mycoides subsp. mycoides
Bertin, PloS one 2013 - “...glucose-6-phosphate to glucose-1-phosphate, which is most probably achieved by the phosphoglucomutase (ManB) predicted in Mmm (MSC_0829, [5] ). It has been shown recently in Vibrio cholerae that glucose PTS permeases are general regulators of genes involved in EPS synthesis [54] . In our model, we hypothesize...”
D8I9Z9 Phosphomannomutase phosphoglucomutase from Brachyspira pilosicoli (strain ATCC BAA-1826 / 95/1000)
25% identity, 84% coverage
- The Exposed Proteomes of Brachyspira hyodysenteriae and B. pilosicoli
Casas, Frontiers in microbiology 2016 - “...protein BP951000_0575 120 D8IBQ3 BP951000_0575 BRAPL Unchar D8ICF3 114 D8ICF3 BP951000_0828 BRAPL Phosphomannomutase phosphoglucomutase 112 D8I9Z9 manB BRAPL Transposase 106 K0JKA8 WESB_1932 BRAPL Inositol-1-monophosphatase 98 C0QX44 , D8IBH8 suhB C Unchar D8IEP8 90 D8IEP8 BP951000_1640 BRAPL PTS system glucose subfamily IIA subunit 90 D8IBR5 ptsG BRAPL...”
AAV49510.1 phosphoglucomutase from Acidithiobacillus ferrooxidans (see paper)
AFE_2324 alpha-D-glucose phosphate-specific phosphoglucomutase from Acidithiobacillus ferrooxidans ATCC 23270
27% identity, 74% coverage
- CRISPR/dCas12a knock-down of Acidithiobacillus ferrooxidans electron transport chain bc<sub>1</sub> complexes enables enhanced metal sulfide bioleaching
Jung, The Journal of biological chemistry 2024 - “...extracellular polymeric substance (EPS) precursors UDP-glucose, UPD-galactose, and dTDP-rhamnose ( luxA , AFE_2321; pgm , AFE_2324; galU ; and AFE_2323) ( 55 ), and genes encoding two distinct signaling mechanisms of quorum sensing ( afeI , AFE_1999) ( 54 ) and c-di-GMP (AFE_0053, AFE_1172, AFE_1360, AFE_1373,...”
- Anaerobic sulfur metabolism coupled to dissimilatory iron reduction in the extremophile Acidithiobacillus ferrooxidans
Osorio, Applied and environmental microbiology 2013 - “...OMPP1/FadL/TodX family OMPP1/FadL/TodX family qPCRf 1.0 1.0 2.3 5.6 AFE_2324 AFE_2542b AFE_2542b Median gene log2 ratio 0.8 4.3 0.9 0.7 0.9 0.9 1.7 O2 Fe3 0.8...”
- “...pyridine binding domain protein; AFE_2324, phosphoglucomutase; AFE_2924, glucose-6-phosphate isomerase (EC 5.3.1.9); AFE_1802, fructose-bisphosphate...”
- Development of a markerless gene replacement system for Acidithiobacillus ferrooxidans and construction of a pfkB mutant
Wang, Applied and environmental microbiology 2012 - “...pgm pgi zwf pfkB AFE_1691 AFE_3051 AFE_2155 AFE_2324 AFE_2924 AFE_2025 AFE_1807 Ribulose bisphosphate carboxylase large chain Ribulose bisphosphate carboxylase...”
- Extending the models for iron and sulfur oxidation in the extreme acidophile Acidithiobacillus ferrooxidans
Quatrini, BMC genomics 2009 - “...S AFE_2971 cysN2 sulfate adenylyltransferase, large subunit -1,3 S AFE_0282 fur ferric uptake regulator 0,6 AFE_2324 pgm phosphoglucomutase 0,6 AFE_0445 galU UTP-glucose-1-phosphate uridylyltransferase 0,2 AFE_1342 epsS UDP-glucose 4-epimerase 0,0 AFE_2840 malQ glycosyl hydrolase -0,2 AFE_2836 glbB 1,4-alpha-glucan branching enzyme -0,6 AFE_3054 cbbOIb von Willebrand factor type...”
cgd2_3260 phosphoglucomutase, tandemly duplicated gene from Cryptosporidium parvum Iowa II
24% identity, 64% coverage
- Implication of Potential Differential Roles of the Two Phosphoglucomutase Isoforms in the Protozoan Parasite Cryptosporidium parvum
Nie, Pathogens (Basel, Switzerland) 2021 - “...Cryptosporidium genomes. In C. parvum , the two PGM isoforms were encoded at the loci cgd2_3260 and cgd2_3270 and their predicted ORFs (1707 and 2013 bp, respectively) were separated by a 210-base intergenic space ( Figure 1 B). Based on NCBIs conserved domain database (CDD) (...”
- “...deoxyribose-1-phosphate to the corresponding 5-phosphopentoses), we named the two C. parvum PGM isoforms as CpPGM1A (cgd2_3260) and CpPGM1B (cgd2_3270) to clarify that they were PGM1 subfamily enzymes. Based a common practice in the field, CpPGM1A and CpPGM1B in italics were used for gene names, and CpPGM1A...”
- Two Phosphoglucomutase Paralogs Facilitate Ionophore-Triggered Secretion of the Toxoplasma Micronemes
Saha, mSphere 2017 - “...PGM1 (GnPGM1) [ GNI_111250 ], Cryptosporidium parvum PGM1.1 (CpPGM1.1) [ cgd2_3270 ] and CpPGM1.2 [ cgd2_3260 ], Cryptosporidium muris PGM1.1 (CmPGM1.1) [ CMU_003300 ] and CmPGM1.2 [ CMU_003310 ], Cryptosporidium hominis PGM1 (ChPGM1) [ Chro.20343 ], Chromera velia PGM1 (CvPGM1) [ Cvel_11076 ] and CvPGM2 [...”
MMCAP2_0733 phospho-sugar mutase from Mycoplasma mycoides subsp. capri str. GM12
26% identity, 90% coverage
Synpcc7942_0156 phosphoglucomutase from Synechococcus elongatus PCC 7942
26% identity, 90% coverage
W7LNK6 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) from Gibberella moniliformis (strain M3125 / FGSC 7600)
27% identity, 91% coverage
Q9SM60 Phosphoglucomutase, cytoplasmic from Pisum sativum
28% identity, 67% coverage
Q670S5 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Trypanosoma cruzi (see paper)
28% identity, 67% coverage
CD630_27800, CDIF630erm_03043 phospho-sugar mutase from Clostridioides difficile
CD2780 putative phosphomannomutase/phosphoglycerate mutase from Clostridium difficile 630
24% identity, 84% coverage
- Iron Regulation in Clostridioides difficile
Berges, Frontiers in microbiology 2018 - “...family protein 0.98 -0.10 1.26 0.10 CD630_27790 CDIF630erm_03042 manC Mannose-1-phosphate guanylyltransferase 1.33 0.81 2.47 0.33 CD630_27800 CDIF630erm_03043 pgm Phosphoglucomutase 2.75 0.22 3.20 0.06 CD630_27810 CDIF630erm_03044 mviN Transmembrane virulence factor 3.67 -0.93 4.13 0.78 CD630_02840 CDIF630erm_00408 PTS system mannose/fructose/sorbose transporter subunit IIA -0.04 0.88 CD630_02850 CDIF630erm_00409 PTS...”
- “...protein 0.98 -0.10 1.26 0.10 CD630_27790 CDIF630erm_03042 manC Mannose-1-phosphate guanylyltransferase 1.33 0.81 2.47 0.33 CD630_27800 CDIF630erm_03043 pgm Phosphoglucomutase 2.75 0.22 3.20 0.06 CD630_27810 CDIF630erm_03044 mviN Transmembrane virulence factor 3.67 -0.93 4.13 0.78 CD630_02840 CDIF630erm_00408 PTS system mannose/fructose/sorbose transporter subunit IIA -0.04 0.88 CD630_02850 CDIF630erm_00409 PTS system...”
- A Clostridium difficile Cell Wall Glycopolymer Locus Influences Bacterial Shape, Polysaccharide Production and Virulence
Chu, PLoS pathogens 2016 - “.... difficile strain 630 genome sequence, were targeted for disruption: CD2783, CD2781 ( mviN ), CD2780 ( pgm2 ), CD2779 ( manC ), CD2769, CD2765 ( lcpA ), and CD2766 ( lcpB ). The gene-specific ClosTron insertion site was chosen based on the Perutka algorithm [...”
- “...we were unable to disrupt five genes in the CWG biosynthetic locus (CD2783, mviN , CD2780, CD2779, and CD2769) via ClosTron mutagenesis. However, mviN expression was successfully diminished using an antisense RNA approach, and resulted in multiple phenotypes. First, mviN -specific antisense RNA-expressing bacteria exhibited a...”
- Clostridium difficile surface proteins are anchored to the cell wall using CWB2 motifs that recognise the anionic polymer PSII
Willing, Molecular microbiology 2015 - “...John Wiley & Sons Ltd Attempts to use a group II intron to insertionally inactivate CD2780 ( pgm2 ), CD2775 (CDPglycerol:polyglycerol phosphate glycerophosphotransferase) and CD2762 ( uppS2 ) consistently failed, suggesting these genes may be essential for bacterial growth (data not shown). We decided to use...”
- “...previously (Fagan and Fairweather, 2011 ). Three plasmids were constructed, which contained antisense targeted to CD2780 ( pgm2 ) (pSEW036), CD2762 ( uppS2 ) (pSEW037) and CD2781 (pSEW038). The plasmids contain 170bp of DNA antisense to the 5 of the target mRNA, including the translational start...”
- Transcriptional analysis of temporal gene expression in germinating Clostridium difficile 630 endospores
Dembek, PloS one 2013 - “...0.0182 +2.5 CD2778 putative polysaccharide biosynthesis protein 0.0311 +2.5 CD2779 putative mannose-1-phosphate guanylyltransferase 0.0116 +2.2 CD2780 putative phosphomannomutase/phosphoglycerate mutase 0.00636 +2.7 Toxins Of central importance in C. difficile is the pathogenicity locus (PaLoc) containing five genes encoding two large clostridial toxins: TcdA and TcdB as well...”
- Microarray identification of Clostridium difficile core components and divergent regions associated with host origin
Janvilisri, Journal of bacteriology 2009 - “...proteins. Most CDS in the capsule-related cluster (CD2769 to -CD2780) and the type IV pilus-associated loci (CD3294 to CD3297 and CD3503 to CD3513) were present...”
X276_21930 phospho-sugar mutase from Clostridium beijerinckii NRRL B-598
24% identity, 83% coverage
- Acidogenesis, solventogenesis, metabolic stress response and life cycle changes in Clostridium beijerinckii NRRL B-598 at the transcriptomic level
Patakova, Scientific reports 2019 - “...hydrolase (X276_01030), glgP (X276_01025), glgA (X276_01020) and glgB (X276_01015). A further glucose phosphomutase gene, pgm (X276_21930) was also found. A similar organization of granulose-involved genes was found in C . beijerinckii NCIMB 8052. Liu et al . 79 described transcription of granulose-involved genes in C ....”
- “...the following steps: formation of glucose-1-phosphate from glucose -6-phosphate catalysed by phospho glucose mutase (gene X276_21930), activation of glucose-1-phosphate with ATP resulting in ADP-glucose catalysed by glucose-1-phosphate adenyl transferase, glgC , glgD (genes X276_01035, X276_01040), then -1,4-glucan synthesis is catalysed by granulose synthase, glgA (X276_01020) and...”
THTE_3829 phospho-sugar mutase from Thermogutta terrifontis
24% identity, 83% coverage
lp_0764 phosphoglucomutase from Lactobacillus plantarum WCFS1
26% identity, 83% coverage
B9SP64 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) from Ricinus communis
27% identity, 67% coverage
- Proteomic Analysis of Embryo Isolated From Mature Jatropha curcas L. Seeds
Ramzan, Frontiers in plant science 2022 - “...B9RHY3 AT1G79550.2 Jcr4s28329.10 Phosphoglycerate mutase B9RF09 AT3G05170.1 Jcr4S00171.20 Phosphopyruvate hydratase (enolase) B9R9N6 AT2G36530.1 Jcr4S00445.90 Phosphoglucomutase B9SP64 AT1G70730.3 Jcr4S00575.60 Pyruvate dehydrogenase E1 component alpha subunit B9S2H9 AT1G59900.1 Jcr4S01924.60 Dihydrolipoamide acetyltransferase B9SL87 AT3G52200.1 Jcr4S00306.100 Dihydrolipoamide acetyltransferase B9S5V2 AT1G54220.2 Jcr4S04485.30 Dihydrolipoyllysine-residue succinyltransferase B9SVA1 AT4G26910.1 Jcr4S00112.10 Dihydrolipoamide dehydrogenase B9RZN2 AT3G16950.1...”
- Common Features Between the Proteomes of Floral and Extrafloral Nectar From the Castor Plant (Ricinus Communis) and the Proteomes of Exudates From Carnivorous Plants
Nogueira, Frontiers in plant science 2018 - “...putative EFN B9SRG1 Enolase, putative Nepenthes Lee et al., 2016 FN/EFN B9RAL0 Glyceraldehyde-3-phosphate dehydrogenase FN/EFN B9SP64 Phosphoglucomutase, putative UNKNOWN FUNCTION FN B9RQ33 5-methyltetrahydropteroyltriglutamatehomocysteine methyltransferase, putative FN B9S0I6 DNA binding protein, putative FN B9SKK5 Nucleoside diphosphate kinase FN B9SCN6 Putative uncharacterized protein FN/EFN B9RWF4 Elongation factor 1-alpha...”
PMM0278 Phosphotransferase superclass from Prochlorococcus marinus sp. MED4
24% identity, 90% coverage
Q9SGC1 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Arabidopsis thaliana (see paper)
28% identity, 65% coverage
MAB_3661 Probable phosphomannomutase PmmB from Mycobacterium abscessus ATCC 19977
27% identity, 88% coverage
Q9AUQ4 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) from Oryza sativa subsp. japonica
XP_015632142 phosphoglucomutase, cytoplasmic 2 from Oryza sativa Japonica Group
28% identity, 67% coverage
- Relationship between Protein, MicroRNA Expression in Extracellular Vesicles and Rice Seed Vigor
Wu, International journal of molecular sciences 2024 - “...O82451 Probable glutathione S-transferase GSTF2 Most abundance Q33AE4 Phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) Most enriched pathway or terms Q9AUQ4 Phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) Most enriched pathway or terms P17784 Fructose-bisphosphate aldolase 1, cytoplasmic Most enriched pathway or terms Q5N725 Fructose-bisphosphate aldolase 3, cytoplasmic Most enriched pathway or terms P42862 Glucose-6-phosphate isomerase,...”
- Unique and Shared Proteome Responses of Rice Plants (Oryza sativa) to Individual Abiotic Stresses
Habibpourmehraban, International journal of molecular sciences 2022 - “...response to all three stresses; Epimerase domain-containing protein (Q2QSR7), L-ascorbate peroxidase 8 (Q69SV0), and Phosphoglucomutase (Q9AUQ4). The only protein with changes in abundance occurring in contrasting directions in response to different stresses was Peptidyl-prolyl cis-trans isomerase (Q69WA8), with a similar increase in abundance of 1.99-fold change...”
- “...protein Q2QSR7 1.64 1.67 1.81 1.77 L-ascorbate peroxidase 8 Q69SV0 1.41 1.49 1.61 1.38 Phosphoglucomutase Q9AUQ4 1.36 1.48 1.75 2.26 Glucan endo-1,3-beta-D-glucosidase A0A0P0XDW1 3.77 7.14 7.25 3.83 Beta-glucosidase 31 B7F7K7 4.63 7.76 4.51 3.86 Aspergillus nuclease S1 B9FCW0 9.44 5.64 5.49 4.69 Aldo_ket_red domain-containing Q0JCV5 4.85...”
- ITRAQ-based quantitative proteomic analysis of japonica rice seedling during cold stress
Qing, Breeding science 2022 - “...4 3.93 0.40 Q10RI4 Os03g0158500 protein 5 8.77 2.17 Q10N92 Os03g0278200 protein 5 9.78 2.25 Q9AUQ4 Os03g0712700 protein 32 51.03 1.42 Q8S7H8 Os03g0778100 protein 11 37.29 2.29 B9F813 Os04g0234600 protein 38 57.91 1.89 Q0JAF4 Os04g0602100 protein 19 43.63 1.77 Q75IR7 Os05g0163000 protein 15 26.73 1.46 Q0DK70...”
- Proteomics and Post-Translational Modifications of Starch Biosynthesis-Related Proteins in Developing Seeds of Rice
Tappiban, International journal of molecular sciences 2021 - “...in the metabolism regulation [ 34 ]. Lysine residue at 18 positions on PGM (Uniprot: Q9AUQ4) was targeted for both acetylation and succinylation modifications ( Table 5 ). Previous studies indicated that succinylation has a potential impact on protein structure and functions [ 136 ] as...”
- “...S155, S869 indica [ 28 ] Pho1 Q9AUV8 S494, S645 indica [ 28 ] PGM Q9AUQ4 S124 japonica [ 31 ] Q33AE4 S167 japonica [ 31 ] - - indica [ 88 ] a S and T indicate the phosphorylated site on serine and threonine residues,...”
- Global Proteomic Analysis Reveals Widespread Lysine Succinylation in Rice Seedlings
Zhang, International journal of molecular sciences 2019 - “...diphosphate kinase Q5TKF4 participates in purine metabolism. UTPglucose-1-phosphate uridylyltransferase Q93X08, UDPglucose 6-dehydrogenase Q9AUV6, and phosphoglucomutase Q9AUQ4 participate in starch and sucrose metabolism. 2.9. Alternative Lysine Succinylation and Acetylation in Rice Seedlings It has been reported that many PTMs can occur at the same protein motifs [...”
- “...S4 and S5 ). The nine proteins were Q0IXR7, Q43008, Q5N725, Q6F361, Q6ZH98, Q7XXS0, Q9ASP4, Q9AUQ4, and Q9SXP2. Interestingly, these proteins were annotated as different kinds of enzymes found in the cytosol, mitochondria, and chloroplast. 3. Discussion We have here provided a comprehensive analysis of the...”
- Comprehensive Analysis of the Lysine Succinylome and Protein Co-modifications in Developing Rice Seeds
Meng, Molecular & cellular proteomics : MCP 2019 (secret) - A proteomic study on molecular mechanism of poor grain-filling of rice (Oryza sativa L.) inferior spikelets
Zhang, PloS one 2014 - “...7 DR 66 g Q10DZ9 Phosphoglucomutase, cytoplasmic 2 243 54.7/4.93 2 DR 5 273 h Q9AUQ4 Phosphoglucomutase 239 62.9/5.63 17 DR 6 268 h Q33AE4 Phosphoglucomutase 53 66.1/6.68 2 DR 7 78 g Q93X08 Similar to UTPglucose-1-phosphateuridylyltransferase 108 51.8/5.43 2 DR 276 h Q93X08 UDP-glucose pyrophosphorylase...”
- “...1.1 Sugars conversion 1 P 1 Q33AE4 Phosphoglucomutase 106 66.1/6.70 9 DR DR 2 P5 Q9AUQ4 Phosphoglucomutase 276 62.9/5.60 22 UR 3 P 9 Q93X08 UDP-glucose pyrophosphorylase 134 51.7/5.60 2 DR 4 P26 Q6ZBH2 Putative sorbitol dehydrogenase 263 39.3/6.47 18 DR 5 P63 Q8S9Z2 Putative dTDP-glucose...”
- Plastidial Phosphoglucomutase (pPGM) Overexpression Increases the Starch Content of Transgenic Sweet Potato Storage Roots
Wang, Genes 2022 - “...A. thaliana , At1g23190; P. sativum , AJ250769; Sesamum indicum , XP_011070593; Oryza sativa , XP_015632142; Sorghum bicolor , XP_002466576; Z. mays , U89341; S. cerevisiae , NP_012795. Figure 3 Expression patterns of IbpPGM. ( a ) Expression of IbpPGM in different tissues of Xu 781...”
AT1G70730 phosphoglucomutase, cytoplasmic, putative / glucose phosphomutase, putative from Arabidopsis thaliana
28% identity, 63% coverage
- Physiological and differential protein expression analyses of the calcium stress response in the <i>Drynaria roosii</i> rhizome
Wu, Heliyon 2024 - “...dehydrogenase GDH1 0.513 0.029 Carbohydrate and energy metabolism ( 3 ) Q9SGC1 Phosphoglucomutase, cytoplasmic 2 At1g70730 0.651 0.034 P93306 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2 NAD7 0.235 0.035 P81766 Nucleoside diphosphate kinase 3 0.346 0.049 Material Transport ( 1 ) Q7XSQ9 Aquaporin PIP1-2 PIP1-2 0.644 0.035...”
- Evaluation of protein's interaction and the regulatory network of some drought-responsive genes in Canola under drought and re-watering conditions
Pasandideh, Physiology and molecular biology of plants : an international journal of functional plant biology 2023 - “...AT3G21720 AT2G05710 AT5G43330 AT3G04120 AT1G79550 AT1G70730 AT2G29560 AT5G56350 AT1G53310 AT1G13700 AT5G24420 AT5G13110 AT1G64190 AT2G38040 AT5G15530 ATCG00500...”
- Changes in annual transcriptome dynamics of a clone of Japanese cedar (Cryptomeria japonica D. Don) planted under different climate conditions
Nose, PloS one 2023 - “...r CUST_8654_PI429951308 reCj23286:MSWR:isotig23138 AT1G66430 1.1E-179 - pfkB-like carbohydrate kinase family protein temp-30d -0.88 CUST_6435_PI429951308 reCj21042:MSWR:isotig20894 AT1G70730 0.0 PGM2 phosphoglucomutase/phosphomannomutase family protein temp-7d -0.85 CUST_5677_PI429951308 reCj20278:MSWR:isotig20130 AT3G01510 0.0 LSF1 like sex four 1 temp-0h -0.84 CUST_3410_PI429951308 reCj17995:MSWR:isotig17847 AT4G17770 0.0 TPS5 trehalose phosphatase/synthase 5 temp-0h -0.83 CUST_3679_PI429951308 reCj18266:-SWR:isotig18118...”
- A comprehensive analysis of transcriptomic data for comparison of plants with different photosynthetic pathways in response to drought stress
Karami, PloS one 2023 - “...genes (AT5G08380 (common in C3 and C4) and AT5G08370 (only in C3)) and phosphoglucomutase gene (AT1G70730 (only in C3)) which are involved in the synthesis and breakdown of glucose, as well as raffinose synthase genes (AT3G57520 (common in C3 and C4) and AT5G40390 (only in C4))...”
- What Antarctic Plants Can Tell Us about Climate Changes: Temperature as a Driver for Metabolic Reprogramming
Bertini, Biomolecules 2021 - “...log 2 FC = 2.87), ADP-glucose pyrophosphorylase (AGPase, AT1G74910, log 2 FC = 2.84), phosphoglucomutase (AT1G70730, log 2 FC = 0.94), disproportionating enzyme 2 (DPE2, AT2G40840, log 2 FC = 4.11), and UDP glucose/galactose epimerase 5 (UGE5, log 2 FC = 3.01). In particular, UGPase 1...”
- “...10 3 1.06 AT5G17920 ATCIMS, ATMETS, ATMS1, cobalamin-independent synthase family protein 1.89 10 3 1.01 AT1G70730 Phosphoglucomutase/phosphomannomutase family protein (PGM) 1.22 10 3 0.94 AT3G04770 RPSAb, 40s ribosomal protein SA B 4.08 10 4 0.90 AT4G35090 CAT2, catalase 2 1.85 10 3 0.76 AT1G80380 P-loop containing...”
- Proximal and Distal Parts of Sweetpotato Adventitious Roots Display Differences in Root Architecture, Lignin, and Starch Metabolism and Their Developmental Fates
Singh, Frontiers in plant science 2020 - “...and Tiessen, 2010 Sucrose metabolism Various S_PBL_c20112 Phosphoglucomutase ( IbPGM ) Firon et al., 2013 AT1G70730 Phosphoglucomutase 2 ( PGM2 ) Kofler et al., 2000 Interconversion of glucose 1-phosphate and glucose 6-phosphate S_PBL_c18129 ADP-glucose pyrophosphorylase alpha subunit ( IbAGPa1 ) Firon et al., 2013 ; KJ365312,...”
- Gibberellin Promotes Sweetpotato Root Vascular Lignification and Reduces Storage-Root Formation
Singh, Frontiers in plant science 2019 - “...( SUS4 ) Sucrose metabolism Various S_PBL_c20112 Phosphoglucomutase ( IbPGM ) Firon et al., 2013 AT1G70730 Phosphoglucomutase 2 ( PGM2 ) Interconversion of glucose 1-phosphate and glucose 6-phosphate S_PBL_c18129 ADP-glucose pyrophosphorylase alpha subunit ( IbAGPa1 ) Firon et al., 2013 ; KJ365312, JQ797696, Z79635, X83498, Z46756,...”
- Consequences of Oxidative Stress on Plant Glycolytic and Respiratory Metabolism
Dumont, Frontiers in plant science 2019 - “...1 8 [Cys 349/731 ] Like protein (At5g20280) 13 Phosphoglucomutase PGM3 (At1g23190) 8 13 PGM2 (At1g70730) 8 13 Glucose 6 phosphate isomerase PGIC (At5g42740) 13 Phosphofructokinase PFP- PFK (At1g20950, At1g76550) 8 [Cys 28/586 ] PFP- PFK (At1g12000) 8 [Cys 166 ] PFK7 (At5g56630) 13 PFK1 (At4g29220)...”
- More
F4I6W4 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) from Arabidopsis thaliana
28% identity, 58% coverage
A2CEK3 Phosphoglucomutase 1 from Mus musculus
27% identity, 73% coverage
XP_002527783 phosphoglucomutase, cytoplasmic from Ricinus communis
27% identity, 67% coverage
F1L0Y5 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) from Ascaris suum
25% identity, 88% coverage
RHOM_RS02235 phospho-sugar mutase from Roseburia hominis A2-183
26% identity, 83% coverage
RL4118 putative phosphoglucomutase from Rhizobium leguminosarum bv. viciae 3841
27% identity, 75% coverage
A0A0D9S732 Phosphoglucomutase 1 from Chlorocebus sabaeus
27% identity, 73% coverage
- Proteomic screening identifies RPLp2 as a specific regulator for the translation of coronavirus
Dong, International journal of biological macromolecules 2023 - “...ACSS2 0.72657 A0A0D9RMT2 JADE3 1.602673 A0A0D9SAK3 GK3P 0.603208 117 A0A0D9RP66 AKAP12 1.299936 A0A0D9RW39 HMGCS1 0.72641 A0A0D9S732 PGM1 1.601135 A0A0D9SAI1 Prefoldin subunit 3 0.601226 118 A0A0D9R5A8 NOL7 1.29878 A0A0D9RIZ6 IGF2R 0.723873 A0A0D9S510 HIP1R 1.597174 A0A0D9SCM1 HIST1H1A 0.600121 119 A0A0D9S0S4 GPATCH8 1.291813 A0A0D9RC23 SATB1 0.722077 A0A0D9S3A2 ANKRD13A 1.592199...”
A6QPB5 PGM1 protein from Bos taurus
27% identity, 77% coverage
CNN00430 phosphoglucomutase from Cryptococcus neoformans var. neoformans JEC21
25% identity, 81% coverage
EF2425 phosphoglucomutase/phosphomannomutase family protein from Enterococcus faecalis V583
24% identity, 84% coverage
P93805 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Zea mays (see paper)
C0PHV6 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) from Zea mays
GRMZM2G023289 phosphoglucomutase, cytoplasmic 2 from Zea mays
27% identity, 67% coverage
- Genetic Engineering of Starch Biosynthesis in Maize Seeds for Efficient Enzymatic Digestion of Starch during Bioethanol Production
Niu, International journal of molecular sciences 2023 - “...AGP2 Amyloplast Involvement of ADP-glucose synthesis Fructokinase-1 (EC:2.7.1.4) Q6XZ79 FRK1 Cytosol Fructokinase activity Phosphoglucomutase (EC:5.4.2.2) P93805 N/A Cytosol Interconverting glucose-6-P and glucose-1-P -1,4-glucan phosphorylase (EC:2.4.1.1) B5AMJ8 100285259 Amyloplast * Glycogen phosphorylase activity Granule-bound starch synthase Q93WP1, Q94FZ6 waxy Amyloplast * Transferring glycosyl groups Granule-bound starch synthase...”
- Proteomic Changes in Paspalum fasciculatum Leaves Exposed to Cd Stress
Salas-Moreno, Plants (Basel, Switzerland) 2022 - “...10.7 Cytoplasm 46 Q09054 Glyceraldehyde-3-phosphate dehydrogenase 2 36.519 39.7626112 Zea mays 1.2 8.1 Cytoplasm 47 P93805 Phosphoglucomutase, cytoplasmic 2 63.002 39.4511149 Zea mays 0.3 1.6 Cytoplasm 48 O24047 Malate dehydrogenase 35.475 25.6024096 Mesembryanthemum crystallinum 7.7 7.7 Cytoplasm 49 Q9ZP06 Malate dehydrogenase 1. 35.782 18.4750733 Arabidopsis thaliana...”
- Comparative protein profiles of the Ambrosia plants
Barton, Biochimica et biophysica acta. Proteins and proteomics 2017 - “...Q9FV66 110418 2 100 13 15 1 1 Carbon Fixation Phosphoglucomutase, cytoplasmic 2 Z. mays P93805 63042 4 100 10 21 1 1 1 Glucose Metabolism Phosphoglycerate kinase, cytosolic N. tabacum Q42962 42365 4 100 17 36 1 1 1 Glycolysis Phospholipase D alpha 1 C....”
- Quantitative proteomics suggests changes in the carbohydrate metabolism of maize in response to larvae of the belowground herbivore Holotrichia parallela
Pan, PeerJ 2020 - “...a Description b MW c (kDa) pI d Local e Fold change f Pathway g C0PHV6 Uncharacterized protein 63.00 5.71 Cytoplasmic 1.527 A, C, D, E B6T6S5 Glucose-6-phosphate 1-epimerase 36.60 6.70 Cytoplasmic 1.464 A B4G0K4 Phosphoglycerate kinase 42.41 5.87 Cytoplasmic 1.450 A B4FS87 Glyceraldehyde-3-phosphate dehydrogenase 36.52...”
- SH1-dependent maize seed development and starch synthesis via modulating carbohydrate flow and osmotic potential balance
Zhang, BMC plant biology 2020 - “...2 ( HxK2 , GRMZM2G432801), fructokinase 2 ( FRK2 , GRMZM2G051677), phosphoglucomutase ( PGM1 , GRMZM2G023289), phosphohexose isomerase ( PHI1 , GRMZM2G065083), shrunken 2 ( Sh2 , GRMZM2G429899), brittle endosperm 2 ( Bt2 , GRMZM2G068506), dull endosperm 1 ( Du1 , GRMZM2G141399) and sugary 2 (...”
- Exploring regulatory networks in plants: transcription factors of starch metabolism
López-González, PeerJ 2019 - “...GRMZM2G152908 At5g20830 SUS2 Sucrose synthase 2 GRMZM2G318780 At5g49190 SUS3 Sucrose synthase 3 At4g02280 PGM Phosphoglucomutase GRMZM2G023289 AGPL1 ADP-glucose pyrophosphorylase large subunit 1 GRMZM2G429899 LOC_Os05g50380 At5g19220 AGPL2 ADP-glucose pyrophosphorylase large subunit 2 GRMZM2G027955 LOC_Os01g44220 AGPL3 ADP-glucose pyrophosphorylase large subunit 3 GRMZM2G144002 LOC_Os03g52460 AGPL4 ADP-glucose pyrophosphorylase large subunit...”
- Comparative transcriptome analysis reveals that tricarboxylic acid cycle-related genes are associated with maize CMS-C fertility restoration
Liu, BMC plant biology 2018 - “...GRMZM2G466833 1.92 up Pyruvate metabolism Malate dehydrogenase3 GRMZM2G180625 1.93 up Glycolysis Cytosolic glyceroldehyde-3-phosphate dehydrogenase GAPC2 GRMZM2G023289 2.02 up Glycolysis/Pentose phosphate pathway Phosphoglucomutase 2 GRMZM2G043198 2.07 up Glycolysis/Pentose phosphate pathway Pyruvate dehydrogenase 2 GRMZM2G097226 2.15 up Glycolysis/Pyruvate metabolism Pyruvate dehydrogenase E1 beta subunit GRMZM2G125233 2.28 up Glycolysis...”
- iTRAQ-Based Proteomics Analysis and Network Integration for Kernel Tissue Development in Maize
Zhang, International journal of molecular sciences 2017 - “...glucose pyrophosphorylase (GRMZM2G032003); AGPase3, ADP glucose pyrophosphorylase 3 (GRMZM2G027955); SS, starch synthase (GRMZM2G024993); PGMa, phosphoglucomutase (GRMZM2G023289); GPT, glucose-6-phosphate transmembrane transporter (GRMZM2G140614); PGMb, phosphoglucomutase (GRMZM2G109383). ijms-18-01840-t001_Table 1 Table 1 The information of proteins identified using isobaric tags for relative and absolute quantitation (iTRAQ). Name 10 DAP 20...”
- Proteomic Analysis of Silk Viability in Maize Inbred Lines and Their Corresponding Hybrids
Ma, PloS one 2015 - “...10 GRMZM2G109383 5:1087187410866206 2.90E-261 62 2.7 Zong3 gi|12585310 Phosphoglucomutase, cytoplasmic 2; 63229.9/5.47 541 100 10 GRMZM2G023289 1:267953598267959889 2.70E-267 Nucleotide metabolism 46 3.1 Zong3 gi|414868742 adenine phosphoribosyl transferase 1 [Zea mays] 19507.4/5.14 321 100 5 GRMZM2G131907 1:164655824164658422 8.60E-72 Signal transduction 61 3.0 Zong3 gi|28373358 Chain A, Crystal...”
G0M2V0 Phosphoglucomutase from Lactiplantibacillus pentosus IG1
26% identity, 83% coverage
HSISS4_01102 phospho-sugar mutase from Streptococcus salivarius
24% identity, 86% coverage
- A Genome-Wide CRISPR Interference Screen Reveals an StkP-Mediated Connection between Cell Wall Integrity and Competence in Streptococcus salivarius
Knoops, mSystems 2022 - “...rmlC HSISS4_00724 Rhamnose synthesis protein 0.69 4.77 rmlB HSISS4_00725 Rhamnose synthesis protein 0.85 4.62 pgmA HSISS4_01102 Phosphoglucomutase 0.12 3.61 dgk HSISS4_00536 Lipid carrier recycler 2.28 2.71 murG HSISS4_00684 Peptidoglycan lipid II precursor synthesis 3.98 2.62 HSISS4_00889 Exporter of O-antigen, teichoic acids, lipoteichoic acids (WpsG) 0.24 3.97...”
- “...-Alanyl transfer protein 0.02 1.17 pstC1 HSISS4_00938 Phosphate transport system permease protein 0.03 1.29 pgmA HSISS4_01102 Phosphoglucomutase 0.05 0.98 asp3 HSISS4_01316 Accessory secretory protein 0.04 0.71 pcsB2 HSISS4_00358 GBS d surface immunogenic protein 0.02 1.48 Amino acid metabolism sdaA HSISS4_01162 l -Serine dehydratase, alpha subunit 0.05...”
PGMC1_MAIZE / P93804 Phosphoglucomutase, cytoplasmic 1; PGM 1; Glucose phosphomutase 1; EC 5.4.2.2 from Zea mays (Maize) (see paper)
P93804 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Zea mays (see paper)
GRMZM2G109383 phosphoglucomutase, cytoplasmic 1 from Zea mays
27% identity, 67% coverage
- function: Catalyzes the reversible isomerization of alpha-D-glucose 1- phosphate to alpha-D-glucose 6-phosphate (PubMed:9662542). The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6- bisphosphate (Probable). This enzyme participates in both the breakdown and synthesis of glucose (By similarity).
catalytic activity: alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate (RHEA:23536)
catalytic activity: O-phospho-L-seryl-[protein] + alpha-D-glucose 1-phosphate = alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] (RHEA:68748)
catalytic activity: alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] = O- phospho-L-seryl-[protein] + alpha-D-glucose 6-phosphate (RHEA:68752)
cofactor: Mg(2+) (Binds 1 Mg(2+) ion per subunit.)
subunit: Monomer. - Using high-throughput multiple optical phenotyping to decipher the genetic architecture of maize drought tolerance
Wu, Genome biology 2021 - “...but they have not been reported in regulation of plant drought tolerance. The ZmcPGM2 locus (GRMZM2G109383) showed significant ( P = 2.57 10 7 , MLM) association with i-trait ddT200_D40_R (the ratio of second-order derivative of the 880nm total reflectance under drought stress to second-order derivative...”
- A Gene-Oriented Haplotype Comparison Reveals Recently Selected Genomic Regions in Temperate and Tropical Maize Germplasm
He, PloS one 2017 - “...1.29 0.44 GRMZM2G026643 3 2755128827558978 outer cell layer1, ocl1 TPC 1.66092 ** 4.01 3.47 4.29E-3 GRMZM2G109383 5 1085553910861668 phosphoglucomutase2, pgm2 TMP -1.29784 * 130.18 136.06 0.08 GRMZM5G883855 5 1609208416099014 ameiotic1, am1 TMP -1.33957 * 1.67 0.98 0.80 GRMZM2G087233 5 1943760519439848 QM1 homolog1, qm1 TMP -1.35767 *...”
- “...the target of temperate selection. This is further supported by the fact that two genes, GRMZM2G109383 ( pgm2 ) and GRMZM2G140614 ( Fig 2A ), encoding enzymes that act directly downstream, hexokinase (HXK) and hexose phosphate isomerase (HPI), were also under strong selection in temperate maize...”
- iTRAQ-Based Proteomics Analysis and Network Integration for Kernel Tissue Development in Maize
Zhang, International journal of molecular sciences 2017 - “...(GRMZM2G027955); SS, starch synthase (GRMZM2G024993); PGMa, phosphoglucomutase (GRMZM2G023289); GPT, glucose-6-phosphate transmembrane transporter (GRMZM2G140614); PGMb, phosphoglucomutase (GRMZM2G109383). ijms-18-01840-t001_Table 1 Table 1 The information of proteins identified using isobaric tags for relative and absolute quantitation (iTRAQ). Name 10 DAP 20 DAP 33 DAP 46 DAP Total Nonredundance pericarp...”
- Proteomic Analysis of Silk Viability in Maize Inbred Lines and Their Corresponding Hybrids
Ma, PloS one 2015 - “...Glycan biosynthesis and metabolism 56 3.8 Zong3 gi|12585309 Phosphoglucomutase, cytoplasmic 1; 63285.9/5.46 475 100 10 GRMZM2G109383 5:1087187410866206 2.90E-261 62 2.7 Zong3 gi|12585310 Phosphoglucomutase, cytoplasmic 2; 63229.9/5.47 541 100 10 GRMZM2G023289 1:267953598267959889 2.70E-267 Nucleotide metabolism 46 3.1 Zong3 gi|414868742 adenine phosphoribosyl transferase 1 [Zea mays] 19507.4/5.14 321...”
- Validating Internal Control Genes for the Accurate Normalization of qPCR Expression Analysis of the Novel Model Plant Setaria viridis
Lambret-Frotté, PloS one 2015 - “...746 bp Si021373 GRMZM2G166694 1,30E-121 99.07 99 Cullin TATGGGTCATCAACAGCTTGTC/ GTAGTCCCTCGTGATGAGATCC 112 bp 534 bp Si034613 GRMZM2G109383 9,10E-66 99.09 99 Phosphoglucomutase ACGAGAAGGATTCATCCAAGAC/ CGTGTACTCTTGCATCTTGGAG 98 bp 195 bp Si017354 GRMZM2G018103 9,10E-127 99.19 99 Serine incorporator GACTGCTAACCACCATCCTTTC/ CTTCTTGTTCATCAGCCTTGCT 138 bp 223 bp Si022372 GRMZM2G126010 0 92.53 100 Actin GGACATTAAAGAGAAACTCGCGTA/...”
- Allergen false-detection using official bioinformatic algorithms.
Herman, GM crops & food 2020 - “...7 1 5 P55240 Q8RU73 P37830 Q84J79 P09559 K7WJT8 K7UNW7 P05435 Q948Z8 B6T7B2 P06508 P23509 P93804 Q02254 B4F7S2 Q02060 Rice Tomato Wheat Q6Z782 P14903 P33432 2 A2XMB2 P38416 Q08000 P37833 Q08655 P20158 P46520 Q9SWF5 Q03968 2 Q07661 P10967 1 W5BUF4 P55142 P47921 P12299 P0C5A4 1 Q6QLX4...”
- Selection of an Appropriate Protein Extraction Method to Study the Phosphoproteome of Maize Photosynthetic Tissue
Luís, PloS one 2016 - “...37, 38 P49087 V-type proton ATPase catalytic subunit A 5.88 61 912 39 , 40 P93804 Phosphoglucomutase, cytoplasmic 1 5.46 63 057 41 P08823 RuBisCO large subunit-binding protein subunit alpha, chloroplastic 4.83 57 357 42 P08927 RuBisCO large subunit-binding protein subunit beta, chloroplastic 5.26 57 893...”
- Comparative proteomics analysis of proteins expressed in the I-1 and I-2 internodes of strawberry stolons
Fang, Proteome science 2011 - “...synthase 4 A9PHC5 metal ion binding Populus trichocarpa 42999/5.7 46.5/6.3 74 18 5/2 162 Phosphoglucomutase P93804 magnesium ion binding Zea mays 63286/5.4 60.2/6.1 63 17 9/30 Energy 152 ATP synthase subunit beta, chloroplastic Q9MRR9 ATP binding Brasenia schreberi 53.8/5.2 45.3/4.8 76 27 8/19 153 ATP synthase...”
Q8VX48 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (Fragment) from Triticum aestivum
27% identity, 67% coverage
- A proteomics survey on wheat susceptibility to Fusarium head blight during grain development.
Chetouhi, European journal of plant pathology 2015 - “...binding domain NS NS -0,61(0,07) Energy metabolism Bradi1g51670.1 684 Phosphoglucomutase NS NS -1,58(0,02) Glucose metabolism Q8VX48 715 ATP synthase subunit alpha, chloroplastic NS 0,86(0,0001) NS Energy metabolism P12112 731 Succinate-CoA ligase activity NS NS -0,713(0,05) C3 and C4 cycle Bradi1g07020.1 770 Methylenetetrahydrofolate reductase NS 0,91(0,001) NS...”
J9W313 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) from Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487)
26% identity, 81% coverage
D500_0478 phospho-sugar mutase from Mycoplasma feriruminatoris
25% identity, 86% coverage
Q9SNX2 Phosphoglucomutase, cytoplasmic from Bromus inermis
27% identity, 67% coverage
O49299 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Arabidopsis thaliana (see paper)
AT1G23190 phosphoglucomutase, cytoplasmic, putative / glucose phosphomutase, putative from Arabidopsis thaliana
27% identity, 66% coverage
- Plastidial Phosphoglucomutase (pPGM) Overexpression Increases the Starch Content of Transgenic Sweet Potato Storage Roots
Wang, Genes 2022 - “...AF216580; StpPGM: Solanum tuberosum , NM_001288352; PspPGM: Pisum sativum , AJ250770; AtcPGM: A. thaliana , At1g23190; PscPGM: P. sativum , AJ250769; ZmcPGM: Zea mays , U89341; ScPGM: Saccharomyces cerevisiae , NP_012795. Homology in amino acids is shaded with dark blue (homology = 100%), lightblue (homology 75%)...”
- “...Coffea arabica , XP_027103885; Solanum lycopersicum , XP_004234144; S. tuberosum , NM_001288352; A. thaliana , At1g23190; P. sativum , AJ250769; Sesamum indicum , XP_011070593; Oryza sativa , XP_015632142; Sorghum bicolor , XP_002466576; Z. mays , U89341; S. cerevisiae , NP_012795. Figure 3 Expression patterns of IbpPGM....”
- Consequences of Oxidative Stress on Plant Glycolytic and Respiratory Metabolism
Dumont, Frontiers in plant science 2019 - “...1 8 SUS1 (At5g20830) 1 8 [Cys 349/731 ] Like protein (At5g20280) 13 Phosphoglucomutase PGM3 (At1g23190) 8 13 PGM2 (At1g70730) 8 13 Glucose 6 phosphate isomerase PGIC (At5g42740) 13 Phosphofructokinase PFP- PFK (At1g20950, At1g76550) 8 [Cys 28/586 ] PFP- PFK (At1g12000) 8 [Cys 166 ] PFK7...”
- Temporal regulation of two cytosolic phosphoglucomutases during stigma development in ornamental kale (Brassica oleracea var. acephala)
Li, Plant signaling & behavior 2018 - “...2, AT1G70730, cytoplasmic phosphoglucomutase 3, AT1G23190; UDP-glucose pyrophosphorylase 2, AT5G17310). A heatmap generated for these proteins...”
- “...on the right side. cPGM2: AT1G70730, cPGM3: AT1G23190, UGPase: AT5G17310. B). Both cPGMs and UGPase participate in carbohydrate metabolic pathway. BocPGM3...”
- Primed primary metabolism in systemic leaves: a functional systems analysis
Schwachtje, Scientific reports 2018 - “...0.55 beta-amylase 1 AT5G22510 INV-E 0.54 0.52 alkaline/neutral invertase AT1G22710 SUC2 0.40 sucrose-proton symporter 2 AT1G23190 PGM3 0.38 Phosphoglucomutase/phosphomannomutase family protein AT3G08590 iPGAM2 0.31 Phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent AT4G23010 UTR2 0.76 UDP-galactose transporter 2 AT1G14360 UTR3 1.05 UDP-galactose transporter 3 AT4G25000 AMY1 1.27 1.38 alpha-amylase-like protein AT2G02810...”
- A comparative transcriptomic analysis reveals the core genetic components of salt and osmotic stress responses in Braya humilis
Zhao, PloS one 2017 - “...protein kinase 2 . 10 ( At1g60940 , SnRK2 . 10 ), phosphoglucomutase 3 ( At1g23190 , PGM3), EPS15 homology domain 1 ( At3g20290 , EHD1 ), vesicle-associated membrane protein 711 ( At4g32150 , VAMP711 ), and glutamate dehydrogenase 2 ( At5g07440 , GDH2 ) genes...”
- Genome-wide analysis of starch metabolism genes in potato (Solanum tuberosum L.)
Van, BMC genomics 2017 - “...2 (PGI-like2) PGSC0003DMG400030128 PGSC0003DMT400077470 Phosphoglucomutase 1 (PGM1) Sotub03g007170.1.1 NM_001288352.1 At5g51820 Phosphoglucomutase 2.1 (PGM2.1) Sotub07g017160.1.1 NM_001288404.1 At1g23190 Phosphoglucomutase 2.2 (PGM2.2) chr04:35711900..35685400 At1g23190 Putative Phosphoglucomutase (pPGM) Sotub05g017780.1.1 At1g70820 Starch Synthase I (SS1) PGSC0003DMG402018552 PGSC0003DMT400047731 Sotub03g013130.1.1 NM_001288145.1 At5g24300 Starch Synthase II (SS2) PGSC0003DMG400001328 PGSC0003DMT400003356 Sotub02g034860.1.1 NM_001288048.1 At3g01180 Starch Synthase...”
- A Shortest-Path-Based Method for the Analysis and Prediction of Fruit-Related Genes in Arabidopsis thaliana
Zhu, PloS one 2016 - “...rhythm, entrainment of the circadian clock by photoperiod, flower development [ 43 , 44 ] AT1G23190 PGM Phosphoglucomutase 3 Carbohydrate metabolic process, glucose metabolic process [ 45 , 46 ] AT4G33010 GLDP1 Glycine decarboxylase P-protein 1 Oxidation reduction, glycine catabolic process, response to cadmium ion [...”
- “...the two above-mentioned genes, contribute to the development and maturity processes of fruits. Another gene, AT1G23190 [also known as phosphoglucomutase 3 (PGM3)], is also on our list of known genes. Such gene not only participates in photosynthesis associated biological processes and glucose metabolic processes as widely...”
- Transcriptomic and proteomic approach to identify differentially expressed genes and proteins in Arabidopsis thaliana mutants lacking chloroplastic 1 and cytosolic FBPases reveals several levels of metabolic regulation
Soto-Suárez, BMC plant biology 2016 - “...into this cluster (Additional file 2 : Table S2). These include phosphoglycerate kinase (At3g12780), phosphoglucomutase (At1g23190), glucose-6-phosphate isomerase (At5g42740), PFK7 and PFK2-phosphofructokinase (At5g56630 and At5g47810), glyceraldehyde-3-phosphate dehydrogenase (At3g04120), 2,3-bisphosphoglycerate mutase 1 (At1g09780), and pyruvate kinase (At5g63680). Clustering analysis also revealed groups of co-ordinately expressed genes in...”
- “...specific root transcriptional re-adjustment included the up- and down-regulation of 2,3-bisphosphoglycerate mutase (At3g08590) and phosphoglucomutase (At1g23190), respectively. The cyfbp root tissue showed a rise in transcript levels of genes encoding for phosphoglucomutase (At1g23190), glucose-6-phosphate isomerase (At5g42740), PFK7 and PFK2-phosphofructokinase (At5g56630 and At5g47810), the cytosolic glyceraldehyde-3-phosphate dehydrogenase...”
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- Disclosing proteins in the leaves of cork oak plants associated with the immune response to Phytophthora cinnamomi inoculation in the roots: A long-term proteomics approach
Coelho, PloS one 2021 - “...0.2 40S ribosomal protein S4-1 RS41 O23254 0.837 1.142 0.041 0.2 Serine hydroxymethyltransferase 4 GLYC4 O49299 2.435 3.204 0.002 0.2 Probable phosphoglucomutase, cytoplasmic 1 PGMC1/PGM1 Proteins less abundant in P . cinnamomi inoculated samples compared to the control F4J3Q8 0.345 0.099 0.004 -3.5 P-loop containing nucleoside...”
- “...Q9LF98 Fructose-bisphosphate aldolase 8 (ALFC8/FBA8) Cytoplasm Glycolysis; Stress signalling -0.3 Monosaccharide catabolic process (6) 6 O49299 Probable phosphoglucomutase, cytoplasmic 1 (PGMC1/PGM1) Cytoplasm Carbohydrate metabolism 0.2 4.6 Q42525 Hexokinase-1 (HXK1) Cytoplasm Nucleous Glycolysis; Stress signalling -0.3 4.6 Q9SAU2 D-ribulose-5-phosphate-3-epimerase (Q9SAU2/RPE) Chloroplast Photosynthesis -0.2 Cellular metabolic compound salvage...”
SiRe_1800 phosphoglucosamine mutase from Sulfolobus islandicus REY15A
23% identity, 92% coverage
FAD_0602 phosphoglucosamine mutase from Ferroplasma acidiphilum
24% identity, 89% coverage
- Metabolic and evolutionary patterns in the extremely acidophilic archaeon Ferroplasma acidiphilum YT
Golyshina, Scientific reports 2017 - “...triosephosphate isomerase (FAD_0107); 21, fructose-2,6-bisphosphatase (FAD_0332); 22,6-phosphofructokinase (FAD_0353); 23, bifunctional phosphoglucose/phosphomannose isomerase (FAD_0562); 24, phosphoglucomutase/phosphomannomutase (FAD_0602); 25, transketolase (FAD_14771476); 26, transaldolase (FAD_1201; FAD_1475); 27, ribulose-phosphate 3-epimerase (FAD_0295). Abbreviations used: Fd, electron carrier ferredoxin; NAD, nicotinamide adenine dinucleotide; CoA, Coenzyme-A; PEP, phosphoenolpyruvate; UQ, ubiquinone. Enzymes labeled in...”
6snoA / P36871 Crystal structures of human pgm1 isoform 2 (see paper)
26% identity, 73% coverage
- Ligands: zinc ion; 1-o-phosphono-alpha-d-glucopyranose (6snoA)
Q6S3D6 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) from Populus tomentosa
27% identity, 66% coverage
Q9ZSQ4 Phosphoglucomutase, cytoplasmic from Populus tremula
26% identity, 66% coverage
- Physiological and Transcriptional Responses of Apocynum venetum to Salt Stress at the Seed Germination Stage.
Li, International journal of molecular sciences 2023 - “...dehydrogenase GAPA1 3.85 GAPC2 Q9FX54 Glyceraldehyde-3-phosphate dehydrogenase GAPC2 3.65 PGMP Q9M4G5 Phosphoglucomutase, chloroplastic 3.47 PGM1 Q9ZSQ4 Phosphoglucomutase, cytoplasmic 3.20 Gcg P55095 Pro-glucagon 12.87 PSL5 Q9FN05 Probable glucan 1,3-alpha-glucosidase 3.31 UGD3 Q9AUV6 UDP-glucose 6-dehydrogenase 3 3.50 UGPA P19595 UTP--glucose-1-phosphate uridylyltransferase 4.88 Sucrose (3) INVE Q9FK88 Alkaline/neutral invertase...”
- Integrative omics of Lonicera japonica Thunb. Flower development unravels molecular changes regulating secondary metabolites.
Yang, Journal of proteomics 2019 - “...P49612 S-adenosylmethionine synthase 1 40,314 0.26 0.19 0.22 0.21 0.35 0.00681 Amino acid meta. 8 Q9ZSQ4 Phosphoglucomutase, cytoplasmic 63,369 0.14 0.12 0.14 0.27 0.33 0.00000 Glycolysis 9 Q9FGX1 ATP-citrate synthase beta chain protein 2 66,356 0.12 0.11 0.12 0.21 0.28 0.00573 TCA cycle 10 F4K0E8 4-hydroxy-3-methylbut-2-en-1-yl...”
- Hydrogen Peroxide Response in Leaves of Poplar (Populus simonii × Populus nigra) Revealed from Physiological and Proteomic Analyses
Yu, International journal of molecular sciences 2017 - “...PRK Chl AOL56425 92 2 Carbohydrate and energy metabolism (12) 3208 Phosphoglucomutase, cytoplasmic PGM Cyt Q9ZSQ4 115 3 3725 Glyceraldehyde-3-phosphate dehydrogenase 2, cytosolic* GAPDH2 Cyt XP_002318114 374 4 3256 Enolase Cyt Q42971 86 2 3506 Alcohol dehydrogenase* ADH Cyt XP_002302195 133 5 3500 Alcohol dehydrogenase* ADH...”
- Proteome changes in the skin of the grape cultivar Barbera among different stages of ripening.
Negri, BMC genomics 2008 - “...b p I a p I b a.a. cov. c (%) Glycolysis and gluconeogenesis 365 Q9ZSQ4 Cytoplasmic phosphoglucomutase PGluM 68.17 63.12 6.16 5.49 9.6 397 Q42908 2,3-bisphosphoglycerate-independent phosphoglycerate mutase PGlyM-1 63.34 61.18 5.83 5.39 5.7 561 P42896 Enolase ENO-1 52.48 47.91 5.89 5.56 35.5 596 P42896...”
Cbei_0983 phosphoglucomutase/phosphomannomutase alpha/beta/subunit from Clostridium beijerincki NCIMB 8052
24% identity, 83% coverage
BQ10790 Phosphoglucomutase from Bartonella quintana str. Toulouse
27% identity, 84% coverage
XP_002466576 phosphoglucomutase, cytoplasmic 2 from Sorghum bicolor
26% identity, 63% coverage
GNI_111250 cytoplasmic phosphoglucomutase from Gregarina niphandrodes
25% identity, 73% coverage
LSA0521 Phosphoglucomutase from Lactobacillus sakei subsp. sakei 23K
25% identity, 84% coverage
SYNPCC7002_A1492 phosphoglucomutase/phosphomannomutase from Synechococcus sp. PCC 7002
24% identity, 89% coverage
Atu4074 phosphoglucomutase from Agrobacterium tumefaciens str. C58 (Cereon)
ATU_RS19035 alpha-D-glucose phosphate-specific phosphoglucomutase from Agrobacterium fabrum str. C58
26% identity, 75% coverage
- A peptidoglycan N-deacetylase specific for anhydroMurNAc chain termini in Agrobacterium tumefaciens
Gilmore, The Journal of biological chemistry 2024 - “...Other synthetically beneficial hits were a bifunctional purine biosynthesis protein PurH (Atu2823), a phosphoglucomutase ExoC (Atu4074), which is likely involved in exopolysaccharide or lipopolysaccharide production, a SPOR domaincontaining d,d -carboxypeptidase DacA (Atu1505), which cleaves the C-terminal d -alanine from PG pentapeptides, Atu0439, which occurs in a...”
- Comparative Transcriptome Analysis of Agrobacterium tumefaciens Reveals the Molecular Basis for the Recalcitrant Genetic Transformation of Camellia sinensis L
Jin, Biomolecules 2022 - “..., exoY = atu3327 , dcgA = atu1257 , ros = atu0916 , exoC = atu4074 , exoB = atu4166 , dcgB = atu1691 , exoW = atu4058 , crdR = atu0361 , rrpX = atu1631 , speF = atu3196 ) related to EPS [ 40...”
- Dual adhesive unipolar polysaccharides synthesized by overlapping biosynthetic pathways in Agrobacterium tumefaciens
Onyeziri, Molecular microbiology 2022 - “...in the DCR phenotype Eight independent DCR mutants were found to have transposon insertions within ATU_RS19035 ( Fig. 2F ), encoding a gene previously designated as exoC ( Kamoun et al., 1989 ). The exoC gene product encodes a predicted phosphoglucomutase that would catalyze conversion of...”
- “...Genes involved in sugar-nucleotide precursor synthesis Multiple independent mutants were isolated in the exoC gene (ATU_RS19035), in both screening backgrounds ( Fig. 11 , Table S3 ), consistent with the prior screen ( Fig. 2F ). As described earlier, exoC encodes a phosphoglucomutase, predicted to convert...”
Q9D0F9 Phosphoglucomutase-1 from Mus musculus
NP_082408 phosphoglucomutase-1 from Mus musculus
28% identity, 67% coverage
- Proteomic reference map for sarcopenia research: mass spectrometric identification of key muscle proteins of organelles, cellular signaling, bioenergetic metabolism and molecular chaperoning
Dowling, European journal of translational myology 2024 - “...P16858 Glyceraldehyde-3-phosphate dehydrogenase Gapdh 24 80.8 35.8 P09411 Phosphoglycerate kinase 1 Pgk1 37 84.2 44.6 Q9D0F9 Phosphoglucomutase-1 Pgm1 36 77.4 61.4 P17182 Alpha-enolase Eno1 28 79.5 47.1 P52480 Pyruvate kinase PKM Pkm 45 80.2 57.8 Q9R062 Glycogenin-1 Gyg1 11 49.2 37.4 Q9WUB3 Glycogen phosphorylase, muscle Pygm...”
- VPS13D affects epileptic seizures by regulating mitochondrial fission and autophagy in epileptic rats.
Wang, Genes & diseases 2024 - “...Q61838 Q62351 Q64133 Q64337 Q6P1B1 Q6P2B1 Q80X90 Q8BJ71 Q8BMA6 Q91VI7 Q922R8 Q99KK7 Q99LX0 Q9CQT1 Q9CZ44 Q9D0F9 Q9EQK5 Down-regulated A2ASS6 C0HKE6 P10922 P11103 P28659 P49312 P51410 P61255 P61358 P62245 P62274 P62806 P62889 P67984 P84228 P97351 Q62095 Q6ZWU9 Q6ZWV3 Q80U78 Q80XU3 Q8BG05 Q8BP71 Q8BSY0 Q8BVY0 Q8K2F8 Q8R081 Q8VC70...”
- Changes in protein fluxes in skeletal muscle during sequential stages of muscle regeneration after acute injury in male mice.
Bizieff, Scientific reports 2024 - “...18.1169.806%* 8.8452.706%* 1.7030.283% 13 Phosphatidylethanolamine-binding protein 1 P70296 Cytoplasm 23.65810.397% 17.71515.136% 7.514.171% 3.5862.677% 14 Phosphoglucomutase-1 Q9D0F9 Glycolysis 1.3290.513% 12.0666.393% 8.2853.023%* 2.3420.399% 15 Albumin P07724 Extracellular 1.4240.878% 13.6914.993% 15.6292.807%* 7.1283.629% 16 Myosin regulatory light chain 2, skeletal muscle isoform P97457 Myofibril 3.1440.913% 15.7498.367%* 8.7513.235%* 1.7170.263% 17 Myosin-binding...”
- Proteomic profiling of the brain from the wobbler mouse model of amyotrophic lateral sclerosis reveals elevated levels of the astrogliosis marker glial fibrillary acidic protein
Murphy, European journal of translational myology 2023 - “...type 1 2 139.57 0.00241 2.21 P03995 Glial fibrillary acidic protein 9 710.27 0.01580 2.21 Q9D0F9 Phosphoglucomutase-1 2 147.84 0.02593 2.14 Q8BMS1 Trifunctional enzyme subunit alpha, mitochondrial 4 283.71 0.00190 2.13 P51174 Long-chain specific acyl-CoA dehydrogenase, mitochondrial 2 117.66 0.00501 2.01 Q9QYX7 Protein piccolo 3 153.35...”
- Identification and Characterization of Elevated Expression of Transferrin and Its Receptor TfR1 in Mouse Models of Depression.
Chang, Brain sciences 2022 - “...24 14 TF Q921l1 7030 78,841 204 34 Cps1 Q8C196 2995 165,711 85 43 PGM1 Q9D0F9 1366 61,665 34 19 PMM2 Q9Z2M7 1265 27,981 38 10 Pnp P23492 8749 32,541 223 16 INMT P40936 1401 30,068 41 9 Hmgb1 P63158 933 25,049 20 7 Apcs P12246...”
- Comparative Proteomic Analysis of tPVAT during Ang II Infusion.
Liang, Biomedicines 2021 - “...PKN1 Serine/threonine-protein kinase N1 Q8VCW8 ACSF2 Medium-chain acyl-CoA ligase ACSF2, mitochondrial Q8BX80 ENGase Cytosolic endo-beta-N-acetylglucosaminidase Q9D0F9 PGM1 Phosphoglucomutase-1 O88712 CtBP1 C-terminal-binding protein 1 P53986 SLC16A1 Monocarboxylate transporter 1 Q8K1A5 Tmem41b Transmembrane protein 41B Q8BGQ1 VIPAS39 Spermatogenesis-defective protein 39 homolog P70392 RasGRF2 Ras-specific guanine nucleotide-releasing factor 2...”
- “...P12382, O08528, P11798, Q63844, Q8BMB3, P63073, P20444, P42227 Galactose metabolism 4 0.0114 0.5894 0.2500 P12382, Q9D0F9, O08528, P70699 Starch and sucrose metabolism 4 0.0143 0.6137 0.2353 Q9D0F9, O08528, P06745, P70699 Other glycan degradation 3 0.0169 0.6230 0.3000 Q8BX80, Q69ZF3, Q8K2I4 Peroxisome 8 0.0210 0.6757 0.1333 P08228,...”
- A proteome signature for acute incisional pain in dorsal root ganglia of mice.
Pogatzki-Zahn, Pain 2021 - “...Fgb 0.348 18 2.44E-07 Fibrinogen beta chain P58771 Tpm1 0.489 25 4.53E-07 Tropomyosin alpha-1 chain Q9D0F9 Pgm1 0.263 33 1.44E-06 Phosphoglucomutase-1 E9PV24 Fga 0.343 18 9.03E-06 Fibrinogen alpha chain P11276 Fn1 0.211 33 1.62E-05 Fibronectin P21550 Eno3 0.690 17 2.61E-05 Beta-enolase P10107 Anxa1 0.317 16 4.48E-05...”
- Obesogenic Diets Cause Alterations on Proteins and Theirs Post-Translational Modifications in Mouse Brains.
Siino, Nutrition and metabolic insights 2021 - “...(HFD/SD) Fold change (HGD/SD) Function/Biological process P53986 Monocarboxylate transporter 1 0.03 0.72 0.06 Glucose homeostasis Q9D0F9 Phosphoglucomutase-1 0.01 0.08 0.64 Glucose homeostasis Q9CXZ1 NADH dehydrogenase [ubiquinone] iron-sulphur protein 4 0.01 0.39 0.71 Mitochondrial respiration Q99LY9 NADH dehydrogenase [ubiquinone] iron-sulphur protein 5 0.01 0.4 0.47 Mitochondrial respiration...”
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- Sec13 promotes glycolysis by inhibiting Ubqln1 mediated Pgm1 ubiquitination in ALI.
Wu, Biochimica et biophysica acta. Molecular basis of disease 2024 (PubMed)- GeneRIF: Sec13 promotes glycolysis by inhibiting Ubqln1 mediated Pgm1 ubiquitination in ALI.
- In Vitro Skeletal Muscle Model of PGM1 Deficiency Reveals Altered Energy Homeostasis.
Conte, International journal of molecular sciences 2023 - GeneRIF: In Vitro Skeletal Muscle Model of PGM1 Deficiency Reveals Altered Energy Homeostasis.
F6X8Q2 Phosphoglucomutase-1 from Equus caballus
27% identity, 64% coverage
- Quantitative Label-Free Proteomic Analysis of Milk Fat Globule Membrane in Donkey and Human Milk
Zhang, Frontiers in nutrition 2021 - “..., F7BPX8 , F7DG10 , F6U904 , F6VUW2 4.02 1.56E-02 ecb01130 Biosynthesis of antibiotics 7 F6X8Q2 , F6TL52 , F6SX98 , F6Y688 , F6RI26 , L7MRN0 , F6R7J2 3.38 1.58E-02 ecb00561 Glycerolipid metabolism 4 F6TN81 , F6QUF7 , F7B6D0 , F6RI26 7.08 1.79E-02 ecb04612 Antigen processing...”
- “...cascades 4 F6USP9 , F6XSF7 , F6PH38 , F6XGE0 5.74 3.10E-02 ecb00052 Galactose metabolism 3 F6X8Q2 , F7B6D0 , F6SUZ2 10.25 3.33E-02 ecb04611 Platelet activation 5 F6QMB8 , F6XAB0 , F7AQZ6 , K9K4D8 , F6PH38 4.03 3.36E-02 ecb05133 Pertussis 4 Q6TGR2 , Q5XWB8 , F6XSF7 ,...”
Q2UZR2 Phosphoglucomutase-1 from Gallus gallus
26% identity, 75% coverage
D8T2E8 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) from Selaginella moellendorffii
26% identity, 70% coverage
- Phosphoproteomic analysis of the non-seed vascular plant model Selaginella moellendorffii
Chen, Proteome science 2014 - “...AILEGGsDDEGASTEAHGR D8RKK4 SNsFVGTEEYIAPEIIK KCBP-interacting protein kinase Protein. stranslational modification OG5_129514 1E-181 AT3G52890.2 SNsFVGTHEYLAPEIIK Os02g43740.1 SMsFVGTHEYLAPEIIK D8T2E8 ASGAFILTAsHNPGGPHEDFGIK Phosphoglucomutase/phosphomannomutase family protein Glycolysis.PGM OG5_127226 1E-181 AT1G23190.1 ATGAFILTAsHNPGGPTEDFGIK Os03g50480.1 ATGAFILTAsHNPGGPTEDFGIK D8SQG3 sQAGTPEWMAPEVLR Protein kinase superfamily protein Signalling.MAP kinases OG5_130251 1E-181 AT1G08720.1 sTAGTPEWMAPEVLR Os02g50970.2 sTAGTAEWMAPEVLR D8SCJ0 ALVANYNQtPR Cell division cycle...”
F1NN63 Phosphoglucomutase-1 from Gallus gallus
26% identity, 80% coverage
lmo0865 similar to phosphomannomutase from Listeria monocytogenes EGD-e
24% identity, 92% coverage
- Whole genome genetic variation and linkage disequilibrium in a diverse collection of Listeria monocytogenes isolates
Louha, PloS one 2021 - “...1791 80.24 2294555..2297155 accessory Heat shock proteins lmo0756 - 1797 80.51 781896..782801 core ABC Transporters lmo0865 - 1859 83.29 903837..905510 core Amino sugar and nucleotide sugar metabolism lmo2014 - 1888 84.59 2088797..2091454 accessory Glycan biosynthesis and metabolism lmo1611 - 1904 85.3 1654902..1655975 core Aminopeptidase lmo0264 inlE...”
- “...proteins in many prokaryotic genomes [ 46 49 ]. Two other hot spot genes ( lmo0865 , lmo2014 ) are involved in carbohydrate and amino acid metabolism and have shown evidence for recombination in a prior study [ 13 ], indicating that the rapid diversification of...”
- Pyruvate carboxylase plays a crucial role in carbon metabolism of extra- and intracellularly replicating Listeria monocytogenes
Schär, Journal of bacteriology 2010 - “...lmo0514 lmo0530 lmo0556b lmo0715 lmo0769 lmo0863 lmo0864 lmo0865 lmo0971 (dltD) lmo0972 (dltC) lmo0973 (dltB) lmo0974 (dltA)c lmo1042b lmo1043 lmo1044b lmo1045b...”
- “...involved in panthotenate biosynthesis; lmo0769 and lmo0865, encoding -1,6-mannanase and phosphomannomutase, respectively; and several genes involved in cell...”
- Maltose and maltodextrin utilization by Listeria monocytogenes depend on an inducible ABC transporter which is repressed by glucose
Gopal, PloS one 2010 - “...L. monocytogenes EGD-e maltose is taken up and utilized by the proteins encoded by lmo0858 lmo0865 . This assumption was based on a comparison of the genome organization of Lactococcus lactis , Lactobacillus plantarum and Listeria monocytogenes. Lmo0859Lmo0861 are annotated in both ListiList and the ABCdb...”
- Glycerol metabolism and PrfA activity in Listeria monocytogenes
Joseph, Journal of bacteriology 2008 - “...lmo0810 lmo0813 uhpTb,d lmo0859 lmo0860 lmo0861 lmo0862 lmo0865 lmo0875 lmo0876 lmo0877 lmo0878 lmo0880 lmo0913b lmo0914 lmo0915b lmo0916 lmo0917 lmo0956...”
U3J383 Phosphoglucomutase-1 from Anas platyrhynchos platyrhynchos
27% identity, 67% coverage
A0A4W2F139 Phosphoglucomutase-1 from Bos indicus x Bos taurus
26% identity, 76% coverage
HAPS_0849 phospho-sugar mutase from Glaesserella parasuis SH0165
HAPS_0849 phosphomannomutase from Haemophilus parasuis SH0165
25% identity, 87% coverage
- Transcriptome analysis reveals a new virulence-associated trimeric autotransporter responsible for Glaesserella parasuis autoagglutination
Li, Veterinary research 2024 - “...Enhanced autoagglutination was observed in several gene mutants of G. parasuis such as clpP , HAPS_0849, and htrA [ 26 , 44 , 45 ]. On the contrary, deletion of the luxS gene led to weakened autoagglutination of H. parasuis [ 46 ]. It seems that...”
- The Glaesserella parasuis phosphoglucomutase is partially required for lipooligosaccharide synthesis
Feng, Veterinary research 2020 - “...required for polysaccharide formation in G. parasuis . Here, we evaluated the role of the HAPS_0849 gene in LOS synthesis. The G. parasuis SC096 HAPS_0849 mutant produced a highly truncated LOS molecule, although a small fraction of intact LOS was still observed, and this mutant was...”
- “...exhibited phosphoglucomutase (PGM) activity. Heterologous expression of a pgm gene from Escherichia coli in the HAPS_0849 mutant led to restoration of the wild-type LOS glycoform, further demonstrating the PGM function of HAPS_0849 in G. parasuis . The autoagglutination and biofilm formation ability of this strain were...”
PGM1_RABIT / P00949 Phosphoglucomutase-1; PGM 1; Glucose phosphomutase 1; EC 5.4.2.2 from Oryctolagus cuniculus (Rabbit) (see 3 papers)
28% identity, 67% coverage
- function: Catalyzes the reversible isomerization of alpha-D-glucose 1- phosphate to alpha-D-glucose 6-phosphate (PubMed:1328221). The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6- bisphosphate (Probable). This enzyme participates in both the breakdown and synthesis of glucose (By similarity).
catalytic activity: alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate (RHEA:23536)
catalytic activity: O-phospho-L-seryl-[protein] + alpha-D-glucose 1-phosphate = alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] (RHEA:68748)
catalytic activity: alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] = O- phospho-L-seryl-[protein] + alpha-D-glucose 6-phosphate (RHEA:68752)
cofactor: Mg(2+) (Binds 1 Mg(2+) ion per subunit.)
subunit: Monomer. - Skeletal muscle alterations in tachycardia-induced heart failure are linked to deficient natriuretic peptide signalling and are attenuated by RAS-/NEP-inhibition.
Dietl, PloS one 2019 - “...G1SUY2 ALDH2 386 1.4 0.025 Mitochondrial matrix Degradation of aldehyde derivatives, ethanol detoxification Phosphoglucomutase gi|1942196 P00949 PGM1 84 1.6 0.031 Cytoplasm Glycogenolysis Heat shock 27kDa protein 2 gi|291383898 G1T4G1 HSPB2 107 1.2 0.033 Cytoplasm, nucleus Positive regulation of catalytic activity Glycerol-3-phosphate dehydrogenase 1 gi|291389121 P08507 GPD1...”
- Proteomics data of ovine mastitis associated with Mannheimia haemolytica.
Katsafadou, Data in brief 2019 - “...MYH4_RABIT Myosin-4 223841 5.50 50 18/84 13 Q9GL76 PVRL1_PIG Nectin-1 57410 5.80 50 8/44 22 P00949 PGM1_RABIT Phosphoglucomutase-1 61805 6.65 50 6/44 20 P42819 SAA_SHEEP Serum amyloid A protein 12680 6.10 69 6/35 43 A4UMC5 TFP11_RABIT Tuftelin-interacting protein 11 96645 5.60 50 11/53 16 Proteins that...”
- Biology, Mechanism, and Structure of Enzymes in the α-d-Phosphohexomutase Superfamily.
Stiers, Advances in protein chemistry and structural biology 2017 - “...Mg H. sapiens eukaryote P36871 5EPC, 5F9C, 5HSH 562 1.85 N Mg O. cuniculus eukaryote P00949 3PMG, 1VKL, 1JDY, 1LXT, 1C4G, 1C47 561 2.40 Y/N Mg, Ni, Cd, Co G1P6V, G16P P. tetraurelia eukaryote P47244 1KFI, 1KFQ 572 2.40 N Zn, Ca PNGM B. anthracis bacterial...”
PGM5_MOUSE / Q8BZF8 Phosphoglucomutase-like protein 5 from Mus musculus (Mouse) (see paper)
NP_778178 phosphoglucomutase-like protein 5 from Mus musculus
25% identity, 69% coverage
W5PUA9 Phosphoglucomutase-like protein 5 from Ovis aries
25% identity, 69% coverage
BT1548 phosphoglucomutase phosphomannomutase from Bacteroides thetaiotaomicron VPI-5482
26% identity, 83% coverage
PGM5_HUMAN / Q15124 Phosphoglucomutase-like protein 5; Aciculin; Phosphoglucomutase-related protein; PGM-RP from Homo sapiens (Human) (see 2 papers)
25% identity, 69% coverage
- function: Component of adherens-type cell-cell and cell-matrix junctions (PubMed:8175905). Has no phosphoglucomutase activity in vitro (PubMed:8175905).
subunit: Interacts with DMD/dystrophin; the interaction is direct (By similarity). Interacts with UTRN/utrophin (By similarity). - Understanding the molecular mechanisms of human diseases: the benefits of fission yeasts.
Acs-Szabo, Microbial cell (Graz, Austria) 2024 - Proteomic Analysis in Valvular Cardiomyopathy: Aortic Regurgitation vs. Aortic Stenosis.
Holst, Cells 2023 - “...PRPSAP1 Phosphoribosyl pyrophosphate synthase-associated protein 1, PRPP synthase-associated protein 1 0.017 O15061 SYNM Synemin 0.021 Q15124 PGM5 Phosphoglucomutase-like protein 5 0.021 Q9NZ32 ACTR10 Actin-related protein 10 0.012 Q96IZ0 PAWR PRKC apoptosis WT1 regulator protein 0.025 O60825 PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 0.018 P35573 AGL Glycogen debranching enzyme 0.026...”
- The secretome atlas of two mouse models of progeria.
Quintana-Torres, Aging cell 2023 - “...expressed proteins in progeroid mice. Gene symbol UniProt ID Aptamer log 2 FC FDR PGM5 Q15124 seq.25117.17 1.59 1.33E12 DPT Q07507 seq.4979.34 1.14 2.88E12 FMOD Q06828 seq.6367.66 1.36 2.88E12 MFAP4 P55083 seq.5636.10 1.54 5.69E12 GLDN Q6ZMI3 seq.20591.48 1.34 3.60E11 RTN4R Q9BZR6 seq.5105.2 0.82 7.10E11 PCDH8 O95206...”
- Insight into the Molecular Signature of Skeletal Muscle Characterizing Lifelong Football Players
Orrù, International journal of environmental research and public health 2022 - “...1.85 P67809 Nuclease-sensitive element-binding protein 1 YBX1 1.85 Q9H6K4 Optic atrophy 3 protein OPA3 1.85 Q15124 Phosphoglucomutase-like protein 5 PGM5 1.85 Q02224 Centromere-associated protein E CENPE 1.85 P45954 Short/branched chain-specific acyl-CoA dehydrogenase, mitochondrial ACADSB 1.85 Q9H0P0 Cytosolic 5-nucleotidase 3 NT5C3A 1.76 P10809 60 kDa Heat shock...”
- Identification and Verification of the Main Differentially Expressed Proteins in Gastric Cancer via iTRAQ Combined with Liquid Chromatography-Mass Spectrometry
Gao, Analytical cellular pathology (Amsterdam) 2019 - “...20 P26678 Cardiac phospholamban OS=Homo sapiens GN=PLN PE=1 SV=1 (PPLA_HUMAN) 0.440292 4.81 E -06 21 Q15124 Phosphoglucomutase-like protein 5 OS=Homo sapiens GN=PGM5 PE=1 SV=2 (PGM5_HUMAN) 0.442845 5.60 E -06 22 B4DTX5 cDNA FLJ60072, highly similar to Homo sapiens sorbin and SH3 domain containing 1 (SORBS1), transcript...”
- Identification of prothymosin alpha (PTMA) as a biomarker for esophageal squamous cell carcinoma (ESCC) by label-free quantitative proteomics and Quantitative Dot Blot (QDB)
Zhu, Clinical proteomics 2019 - “...P12111 0.321 0.031 Collagen alpha-3(VI) chain P29536 0.000 0.032 Leiomodin-1 P05556 0.416 0.033 Integrin beta-1 Q15124 0.000 0.033 Phosphoglucomutase-like protein 5 P21333 0.213 0.033 Filamin-A Q53GG5 0.013 0.036 PDZ and LIM domain protein 3 P01009 0.429 0.037 Alpha-1-antitrypsin;Short peptide from AAT P43121 0.000 0.038 Cell surface...”
- Proteomic distinction of renal oncocytomas and chromophobe renal cell carcinomas.
Drendel, Clinical proteomics 2018 - “...domain-containing protein 1 (EC 3.1.3.-) 0.91 0.63 0.00 Q92882 Osteoclast-stimulating factor 1 1.21 1.36 0.00 Q15124 Phosphoglucomutase-like protein 5 (Aciculin) (Phosphoglucomutase-related protein) (PGM-RP) 0.29 0.49 0.01 A6NDG6 Glycerol-3-phosphate phosphatase (G3PP) (EC 3.1.3.21) (Aspartate-based ubiquitous Mg(2+)-dependent phosphatase) (AUM) (EC 3.1.3.48) (Phosphoglycolate phosphatase) (PGP) 1.15 1.04 0.00 Q86T03...”
- Sequence-structure relationships, expression profiles, and disease-associated mutations in the paralogs of phosphoglucomutase 1.
Muenks, PloS one 2017 - “...C . albicans ), 4BJU ( A . fumigatus ) 542 5.8 PGM5 aciculin vertebrates Q15124 - 567 6.8 *Only eukaryotic lineages included. Sequence ID, no. residues, and pI correspond to the major transcript of each protein. EC: Enzyme Commission; PDB: Protein Data Bank. Also on...”
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Synpcc7942_1268 Phosphoglucomutase from Synechococcus elongatus PCC 7942
27% identity, 88% coverage
Q4R5E4 Phosphoglucomutase-1 from Macaca fascicularis
27% identity, 67% coverage
PH1210 phospho-sugar mutase from Pyrococcus horikoshii OT3
25% identity, 92% coverage
6y8yA / A0A6P3VN15 Structure of baltic herring (clupea harengus) phosphoglucomutase 5 (pgm5) with bound glucose-1-phosphate (see paper)
26% identity, 73% coverage
- Ligands: calcium ion; 1-o-phosphono-alpha-d-glucopyranose (6y8yA)
W5PJB6 Phosphoglucomutase-1 from Ovis aries
27% identity, 63% coverage
- Proteomics and metabolomics combined study on endopathic changes of water-soluble precursors in Tan lamb during postmortem aging
Ji, Food science & nutrition 2022 - “...1.90E04 W5PF65 Transferrin 0.37 4.91E05 W5PFT7 Fructosebisphosphatase 2 0.41 3.34E04 W5PIN6 Llactate dehydrogenase 0.18 6.18E05 W5PJB6 Phosphoglucomutase 1 0.39 5.28E05 W5PK66 Parkinsonismassociated deglycase 0.46 7.63E04 W5PNJ7 Nucleoredoxin 2.67 4.89E02 W5PQL7 Tropomyosin 2 0.22 2.63E05 W5PS88 Aspartate aminotransferase 0.24 2.94E04 W5PUC1 Carbonic anhydrase 3 0.28 1.14E05 W5PVY5...”
- “...0.39 W5PDG3 Glyceraldehyde3phosphate dehydrogenase 0.41 W5PFT7 Fructosebisphosphatase 2 1.29 0.41 W5PIN6 Llactate dehydrogenase 1.46 0.18 W5PJB6 Phosphoglucomutase 1 1.48 0.39 W5PS88 Aspartate aminotransferase 0.24 W5PVY5 Phosphoglycerate mutase 1.37 0.23 W5Q0I1 Myosin binding protein C, slow type 1.21 0.42 W5Q8N4 Myosin light chain 2 1.76 0.25 W5Q983...”
- Poor maternal diet during gestation alters offspring muscle proteome in sheep
Reed, Journal of animal science 2022 - “...4.33b PGK1 W5QBV3 109.3 7.32 108.1 5.91 82.6 4.47b PGM1 W5PJB6 100.3 2.40 106.5 2.22 93.2 4.11b IMPDH W5Q1I6 96.9 1.68 103.4 4.01 PRDX5 W5PAL7 98.1 2.33 97.2...”
F1S814 Phosphoglucomutase-1 from Sus scrofa
27% identity, 63% coverage
Aflv_2333 Phosphomannomutase from Anoxybacillus flavithermus WK1
24% identity, 82% coverage
- Encapsulated in silica: genome, proteome and physiology of the thermophilic bacterium Anoxybacillus flavithermus WK1
Saw, Genome biology 2008 - “...genes include: the master regulators of biofilm formation AbrB (Aflv_0031) and SinR (Aflv_2245); -phosphoglucomutase YhxB (Aflv_2333), which is probably involved in exopolysaccharide synthesis; EcsB (Aflv_2284), the membrane subunit of an ABC-type transporter that could promote secretion of protein components of the extracellular matrix; an HD-superfamily hydrolase...”
- “...Ortholog COG number abrB BSU00370 Transcriptional regulator Aflv_0031 COG2002 pgcA ( yhxB ) BSU09310 Alpha-phosphoglucomutase Aflv_2333 COG1109 sipW BSU24630 Signal peptidase - COG0681 yqxM BSU24640 Biofilm formation protein - - ecsB BSU10050 ABC transporter subunit Aflv_2284 COG4473 yqeK BSU25630 HD-superfamily hydrolase Aflv_0816 COG1713 ylbF BSU14990 Regulatory...”
Ccel_1417 phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I from Clostridium cellulolyticum H10
Ccel_1417 phospho-sugar mutase from Ruminiclostridium cellulolyticum H10
24% identity, 84% coverage
- Handling Several Sugars at a Time: a Case Study of Xyloglucan Utilization by Ruminiclostridium cellulolyticum
Kampik, mBio 2021 - “...and selected with its product for genetic and biochemical approaches. Finally, the gene at locus Ccel_1417 and its product, the -phosphoglucomutase ( 24 ) ( Fig.1a and b ), were also investigated. Though this enzyme is not the first enzyme of a pathway, it was expected...”
- “...blots as previously described ( 52 ). The unsuccessful inactivation of the gene at locus Ccel_1417 was performed analogously with the primers Ccel_1417-253-IBS/Ccel_1417-253-EBS1d/Ccel_1417-253-EBS2, 1417-769s-IBS/1417-769s-EBS1d/1417-769s-EBS2, or Ccel_1417-933-IBS/Ccel_1417-933-EBS1d/Ccel_1417-933-EBS2. The integration frequency within Ccel_3221 was too low for the isolation of a single colony. As indicated in a study...”
THA_RS09865 phospho-sugar mutase from Thermosipho africanus TCF52B
27% identity, 72% coverage
TDE1998 phosphohexose mutase family protein from Treponema denticola ATCC 35405
25% identity, 86% coverage
E3K5I5 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) from Puccinia graminis f. sp. tritici (strain CRL 75-36-700-3 / race SCCL)
26% identity, 76% coverage
Q08DP0 Phosphoglucomutase-1 from Bos taurus
26% identity, 76% coverage
- Proteomics Unveils Post-Mortem Changes in Beef Muscle Proteins and Provides Insight into Variations in Meat Quality Traits of Crossbred Young Steers and Heifers Raised in Feedlot
Severino, International journal of molecular sciences 2022 - “...14 glucan phosphorylase F1MJ28 7318.068 63.42 7.09/97,750 7.05/97,735 1.13 (UP in steers) 34 PGM1 Phosphoglucomutase-1 Q08DP0 9944.941 78.11 6.99/65,655 7.21/61,874 1.89 (UP in steers) 46 TPI1 Triosephosphate isomerase Q5E956 21,146.33 88.35 7.29/25,236 7.27/26,917 1.28 (UP in steers) 47 AK1 Adenylate kinase isoenzyme 1 P00570 12,755.28 58.76...”
- “...(Bovine) Chr. Marbling score ( n = 4) HSPA8; MYBPC1; PGM1; PYGM A6QP89; P19120; P79334; Q08DP0 Chr.15; Chr.5; Chr.3; Chr.29 Fat thickness at the 12th rib ( n = 4) ATP5F1B; MB; MYBPC1; PGM1 P00829; P02192; A6QP89; Q08DP0 Chr.5; Chr.5; Chr.5; Chr.3 Intramuscular fat ( n...”
- Differences in Beef Quality between Angus (Bos taurus taurus) and Nellore (Bos taurus indicus) Cattle through a Proteomic and Phosphoproteomic Approach
Rodrigues, PloS one 2017 - “...P85100 188 ND h in Nellore 0.0007 100 2 13 5.12/5.00 25.7/22.1 136 Phosphoglucomutase-1 PGM1 Q08DP0 233 2.83 0.0031 100 3 8 6.30/6.36 63.1/61.8 199 Phosphoglucomutase-1 PGM1 Q08DP0 933 2 0.0079 100 11 24 6.64/6.36 62.6/61.8 106 Stress-70 protein, mitochondrial HSPA9 Q3ZCH0 86 1.64 0.0111 99...”
- “...150 Alpha-enolase ENO1 Q9XSJ4 861 2.04 0.0152 100 11 29 6.39/6.37 49.0/47.6 198 Phosphoglucomutase-1 PGM1 Q08DP0 711 3.28 0.0079 100 8 19 6.67/6.36 63.4/61.8 95 Phosphoglucomutase-1 PGM1 A6QPB5 157 1.92 0.0160 100 1 3 5.64/5.48 65.2/62.5 144 78 kDa glucose-regulated protein HSPA5 Q0VCX2 303 2 0.0131...”
- Levels of inflammation and oxidative stress, and a role for taurine in dystropathology of the Golden Retriever Muscular Dystrophy dog model for Duchenne Muscular Dystrophy.
Terrill, Redox biology 2016 - “...O14983 9 15.30.8 30.52.8* Lactoferrin P02788 26 27.32.6 65.74.6* Albumin P49822 33 13.00.8 31.73.0* Phosphoglucomutase Q08DP0 5 12.90.8 31.02.8* Pyruvate kinase P11980 5 11.20.8 24.01.8* Myotilin Q9UBF9 8 12.81.0 25.82.5* Glyceraldehyde-3-phosphate dehydrogenase Q28259 13 10.01.3 15.21.7* Malate dehydrogenase P08249 8 8.60.9 18.72.3* Alpha actin P68138 87...”
- Regional Differences of Proteins Expressing in Adipose Depots Isolated from Cows, Steers and Bulls as Identified by a Proteomic Approach.
Cho, Asian-Australasian journal of animal sciences 2016 - “...Bt.30099 Fatty acid synthase FASN 6.46 274.1 20.7 14.41 8.42 2.37 137.1 189.72 57.99 19 Q08DP0 Bt.59999 Phosphoglucomutase-1 PGM1 6.81 61.6 20.28 22.64 15.64 38.83 0 0 0 20 P19858 Bt.3809 L-lactate dehydrogenase A chain LDHA 8 36.6 18.67 16.69 22.01 35.86 0 2.11 4.31 21...”
- “...Bt.49056 Carbonic anhydrase 3 CA3 7.84 29.4 26.54 21.82 33.88 46.14 0 0 0 2 Q08DP0 Bt.59999 Phosphoglucomutase-1 PGM1 6.81 61.6 20.28 22.64 15.64 38.83 0 0 0 3 F1MJ28 Bt.16003 Phosphorylase PYGM 7.11 97.2 15.32 26.9 27.38 49.74 0 0 0 4 Q3T145 Bt.5345 Malate...”
- Monitoring post mortem changes in porcine muscle through 2-D DIGE proteome analysis of Longissimus muscle exudate.
Di, Proteome science 2013 - “...name Biological process c Peptides pI d MW (kDa) e Score f or g 13 Q08DP0 Phosphoglucomutase-1 PGM1 carbohydrate metabolic process 2 6.4 61.6 f 20.16 13 Q3ZBZ8 Stress induced phosphoprotein 1 STIP1 immune system process; protein metabolic process; response to stress 3 6 62.4 f...”
- “...Q3T0P6 c Phosphoglycerate kinase 1 PGK1 carbohydrate metabolic process 2 8.5 44.5 f 20.28 680 Q08DP0 Phosphoglucomutase-1 PGM1 carbohydrate metabolic process 19 6.4 61.6 g 294 962 Q9HC38 Glyoxalase domain-containing protein 4 GLOD4 metabolic process 2 5.4 34.8 f 20.18 999 Q3SX44 N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 DDAH2...”
SMU_RS04965 phospho-sugar mutase from Streptococcus mutans UA159
23% identity, 84% coverage
cce_0770 phosphoglucomutase/phosphomannomutase from Cyanothece sp. ATCC 51142
25% identity, 89% coverage
- Analysis of Protein Complexes in the Unicellular Cyanobacterium Cyanothece ATCC 51142
Aryal, Journal of proteome research 2018 - “...900, we discuss four interesting examples. Putative homologs of Glucose-1-phosphate adenylytransferase (GlgC2; cce_2658) and phosphoglucomutase (cce_0770) are both involved in the glycogen biosynthesis pathway in ten other organisms. Since proteins involved in the same pathway have a higher probability to interact, it is highly possible that...”
MAP3430 PmmB from Mycobacterium avium subsp. paratuberculosis str. k10
27% identity, 88% coverage
SSA_1204 Phosphoglucomutase from Streptococcus sanguinis SK36
23% identity, 84% coverage
- Involvement of signal peptidase I in Streptococcus sanguinis biofilm formation
Aynapudi, Microbiology (Reading, England) 2017 - “...3.2 30.68 30S ribosomal protein S13 No SSA_0112 3.3 24.53 50S ribosomal protein L22 No SSA_1204 3.4 23.43 Phosphoglucomutase No SSA_1925 3.5 11.65 SerinetRNA ligase No SSA_1950 3.81 11.79 Oligopeptide ABC superfamily ATP binding cassette transporter, binding protein No SSA_0774 4.02 224.38 Glyceraldehyde-3-phosphate dehydrogenase No SSA_1992...”
MAG4650 Phosphomannomutase from Mycoplasma agalactiae PG2
24% identity, 89% coverage
Q3U6X6 Phosphoglucomutase-1 from Mus musculus
28% identity, 67% coverage
BB0835 phosphomannomutase (cpsG) from Borrelia burgdorferi B31
22% identity, 86% coverage
- Functional analysis of Borrelia burgdorferi uvrA in DNA damage protection
Sambir, FEMS microbiology letters 2011 - “...1 and 2). Sequencing a 5.8 kb PCR fragment obtained with primers 12.5 (upstream gene BB0835) and 12.6 (downstream gene BB0838) confirmed homologous DNA exchange between the wild-type chromosomal uvrA Bbu gene in the chromosome and the disrupted uvrA Bbu allele in pBL12. Two plasmids were...”
- “.../ uvrA c This study 12.4 CG TCTAGA TTAGCTATGCGGGAGGCAATTGAG d uvrA This study 12.5 CCCCTTATTCCAGCAGTGCCAAATTCTAGA BB0835 This study 12.6 GCCCATTTTTTTAAATCCTCATCGGTTGAA BB0838 This study AVB3 GTA GAGCTC TGCTTAGAGAGGGCTTAGATATTCCAGAAGT a uvrB This study AVB4 TCATC CTGCAG CTGGGCAAAAATTGCATTAGAAAATGTT e BB0838 This study III ATATCTAGAAAATTCTATCATAATTGTGGTTTCAA Km r Shevchuk et al.,...”
- Characterization of multiprotein complexes of the Borrelia burgdorferi outer membrane vesicles
Yang, Journal of proteome research 2011 - “...detected in most complexes; BB0418, an OM efflux channel protein (BB0142) and a putative phosphomannomutase (BB0835) were intermittently distributed across the complexes. Immunoblot analysis of 2D-BN/SDS-PAGE gels indicated that while La7 is detectable only in MGII group; BB0405, P66, OspC and BmpA subunits are distributed in...”
XP_001875148 phosphoglucomutase from Laccaria bicolor S238N-H82
26% identity, 81% coverage
- Transcriptome and proteome exploration to provide a resource for the study of Agrocybe aegerita
Wang, PloS one 2013 - “...Gene name E-Value Accession no. Organism AA_4781 Glucokinase 2.7E-82 XP_001880386 L. bicolor AA_10967 phosphoglucomutase 0 XP_001875148 L. bicolor AA_32419 UDP-glucose-1-phosphate uridylyltransferase 4.39E-162 XP_001880365 L. bicolor AA_3476 1,3-beta-glucan synthase 0 XP_001878782 L. bicolor AA_2840 1,3-beta-glucan synthase 0 XP_001875386 L. bicolor AA_35913 1,3-beta-glucan synthase 4.39E-135 XP_001878782 L. bicolor...”
PPE_04441 phospho-sugar mutase from Paenibacillus polymyxa E681
25% identity, 84% coverage
PGM5_RAT / D3ZVR9 Phosphoglucomutase-like protein 5 from Rattus norvegicus (Rat) (see paper)
25% identity, 70% coverage
- function: Component of adherens-type cell-cell and cell-matrix junctions. Has no phosphoglucomutase activity in vitro.
subunit: Interacts with DMD/dystrophin; the interaction is direct (By similarity). Interacts with UTRN/utrophin (PubMed:7890770).
MAGa5120 phosphomannomutase from Mycoplasma agalactiae
24% identity, 89% coverage
A1A5L2 Phosphoglucomutase-1 (Fragment) from Rattus norvegicus
27% identity, 64% coverage
NBX27_00660 phosphoglucosamine mutase from Erysipelothrix rhusiopathiae
25% identity, 88% coverage
- Human Erysipelothrix rhusiopathiae infection via bath water - case report and genome announcement
Zautner, Frontiers in cellular and infection microbiology 2022 - “...murI glutamate racemase NBX27_05555 murJ/mviN murein biosynthesis integral membrane protein MurJ NBX27_00365 alr alanine racemase NBX27_00660 glmM phosphoglucosamine mutase NBX27_02455 glmS glutaminefructose-6-phosphate transaminase NBX27_02525 mltG endolytic transglycosylase MltG NBX27_03160 uppS polyprenyl diphosphate synthase NBX27_08340 glmU bifunctional UDP- N -acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase GlmU NBX27_02795 pbp penicillin-binding protein...”
1kfqA / P47244 Crystal structure of exocytosis-sensitive phosphoprotein, pp63/parafusin (phosphoglucomutse) from paramecium. Open form (see paper)
25% identity, 74% coverage
- Ligand: calcium ion (1kfqA)
B5DG72 Phosphoglucomutase-1 from Salmo salar
26% identity, 86% coverage
PGM1_PARTE / P47244 Phosphoglucomutase-1; PGM 1; Glucose phosphomutase 1; Parafusin; Pf; pp63; EC 5.4.2.2 from Paramecium tetraurelia (see paper)
25% identity, 73% coverage
- function: May be involved in membrane fusion in exocytosis
catalytic activity: alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate (RHEA:23536)
cofactor: Mg(2+) Note=Binds 1 Mg(2+) ion per subunit - Biology, Mechanism, and Structure of Enzymes in the α-d-Phosphohexomutase Superfamily.
Stiers, Advances in protein chemistry and structural biology 2017 - “...1LXT, 1C4G, 1C47 561 2.40 Y/N Mg, Ni, Cd, Co G1P6V, G16P P. tetraurelia eukaryote P47244 1KFI, 1KFQ 572 2.40 N Zn, Ca PNGM B. anthracis bacterial Q81VN7 3PDK 448 2.70 N No (pH 4.5) dimer F. tularensis bacterial Q5NII8 3I3W 443 2.30 Y Zn dimer...”
RD1_2870 phosphoglucomutase from Roseobacter denitrificans OCh 114
27% identity, 91% coverage
- Peroxidase activity and involvement in the oxidative stress response of roseobacter denitrificans truncated hemoglobin
Wang, PloS one 2015 - “...3) Gene product 16S rRNA Forward: tgttcggaattactgggcg 16S rRNA gene Reverse: tcgggatttcacccctaactt Glycogenesis and gluconeogenesis RD1_2870 Forward: tgcagccatttgtgaaacat Phosphoglucomutase Reverse: atgcgttttgtgatgtcgaa RD1_2720 Forward: cagtgacgttacggatgtgg Glucose-6-phosphate (pgi) Reverse: aatggtcgtgaaggtcttgg isomerase Carbohydrate catabolism RD1_2879 Forward: CGCACGGTGCTTTTTTCG 6-phosphogluconate dehydrase (edd) Reverse: GTTCCTGCCAGCGGGTC RD1_2878 Forward: CCAGAAGTGGTAATTCCAGCG 2-dehydro-3-deoxy-phospho- (eda) Reverse: TTCACCCGGCGCGAC...”
- “...and subjected to cycles of 12-h light followed by 12-h dark periods (B): 1 . RD1_2870 (phosphoglucomutase); 2 . RD1_2720 (glucose-6-phosphate isomerase); 3 . RD1_2879 (6-phosphogluconate dehydrase); 4 . RD1_2878 (KDPG aldolase); 5 . RD1_3376 (pyruvate carboxylase); 6 . RD1_0421 (malic enzyme); 7 . RD1_1609 (2-ketoglutarate...”
Saci_0806 phosphoglucomutase/phosphomannomutase from Sulfolobus acidocaldarius DSM 639
24% identity, 90% coverage
- Early Response of Sulfolobus acidocaldarius to Nutrient Limitation
Bischof, Frontiers in microbiology 2018 - “...to glucose 6-phosphate (G6P), such as the GLGP ( saci_0294 ) and the PGM ( saci_0806 ) were elevated (Figure 4 and Supplementary Table S2 ). Increasing the degradation of glycogen allows S. acidocaldarius to quickly release glucose intermediates. In addition, glycogen provides a source for...”
TRIVIDRAFT_87728 uncharacterized protein from Trichoderma virens Gv29-8
26% identity, 89% coverage
- Transcriptome Dynamics Underlying Chlamydospore Formation in Trichoderma virens GV29-8
Peng, Frontiers in microbiology 2021 - “...and oxidation-reduction genes were dominant. Enoyl-CoA hydratase (TRIVIDRAFT_87842), glucan endo-1,3-beta-D-glucosidase (TRIVIDRAFT_111476), glucanase (TRIVIDRAFT_89797) and phosphoglucomutase (TRIVIDRAFT_87728) were included ( Supplementary Table 16 , 17 ). The fatty acid degradation (tre00071) pathway was enriched in the dark red and green modules ( Supplementary Tables 19 , 20...”
PGM1_RAT / P38652 Phosphoglucomutase-1; PGM 1; Glucose phosphomutase 1; EC 5.4.2.2 from Rattus norvegicus (Rat) (see paper)
27% identity, 67% coverage
- function: Catalyzes the reversible isomerization of alpha-D-glucose 1- phosphate to alpha-D-glucose 6-phosphate (PubMed:8224913). The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6- bisphosphate (Probable). This enzyme participates in both the breakdown and synthesis of glucose (By similarity).
catalytic activity: alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate (RHEA:23536)
catalytic activity: O-phospho-L-seryl-[protein] + alpha-D-glucose 1-phosphate = alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] (RHEA:68748)
catalytic activity: alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] = O- phospho-L-seryl-[protein] + alpha-D-glucose 6-phosphate (RHEA:68752)
cofactor: Mg(2+) (Binds 1 Mg(2+) ion per subunit.)
subunit: Monomer. - Role of Glycolysis/Gluconeogenesis and HIF-1 Signaling Pathways in Rats with Dental Fluorosis Integrated Proteomics and Metabolomics Analysis.
Ba, International journal of molecular sciences 2022 - “...P04642 2.14 10 2 1.74 Aldob Fructose-bisphosphate aldolase Q66HT1 2.63 10 11 1.67 Pgm1 Phosphoglucomutase-1 P38652 1.12 10 10 1.50 Gpi Glucose-6-phosphate isomerase Q6P6V0 5.78 10 8 1.50 Pgam1 Phosphoglycerate mutase 1 P25113 6.13 10 7 1.48 Pgam2 Phosphoglycerate mutase 2 P16290 2.20 10 9 1.43...”
- Introducing physical exercise as a potential strategy in liver cancer prevention and development
Zamanian-Azodi, Gastroenterology and hepatology from bed to bench 2021 - “...1 Eno1 P04764 35 0.01 2 Gpi 35 0.01 3 Pkm 35 0.04 4 Pgm1 P38652 34 0.03 5 Aldoa 33 0.02 6 Aldoart2 33 0.02 The high valued nodes in degree are called hubs; among them, two nodes, Eno1 and Pgm1, are from the queried...”
- Leucine-Rich Diet Modulates the Metabolomic and Proteomic Profile of Skeletal Muscle during Cancer Cachexia.
Cruz, Cancers 2020 - “...content compared to the W group ( Figure 5 d; Table 2 ). Phosphoglucomutase-1, PGm1 (P38652; Table 2 ) had higher concentrations again in both leucine groups with or without tumour implant than the C and W groups ( Figure 5 e). The present results showed...”
- “...dehydrogenase E1 componentPdhb, accession code P49432 in gastrocnemius muscle. ( e ) Phosphoglucomutase-1Pgm1, accession code P38652 in gastrocnemius muscle. The values are expressed as the difference of maximal fold change. Legend: C, control group; W, Walker tumour-bearing group; L, rats fed a leucine-rich diet; WL, tumour-bearing...”
- Myocardial proteomic profile in pulmonary arterial hypertension.
Hołda, Scientific reports 2020 - “...1 1.28 P16409 Myl3 Myosin light chain 3 1.12 P10715 Cyct Cytochrome c, testis-specific 1.27 P38652 Pgm1 Phosphoglucomutase-1 1.11 Q5RKI1 Eif4a2 Eukaryotic initiation factor 4A-II 1.26 P68035 Actc1 Actin, alpha cardiac muscle 1 1.10 Q63716 Prdx1 Peroxiredoxin-1 1.10 P10888 Cox4i1 Cytochrome c oxidase subunit 4 isoform...”
- Functional proteomic analysis of corticosteroid pharmacodynamics in rat liver: Relationship to hepatic stress, signaling, energy regulation, and drug metabolism.
Ayyar, Journal of proteomics 2017 - “...P07379 Pck1 Phosphoenolpyruvate carboxykinase, cytosolic Gluconeogenesis - conversion of oxaloacetate to phosphoenolpyruvate (rate-limiting step) UP P38652 Pgm1 Phosphoglucomutase-1 Breakdown and synthesis of glucose UP/DOWN P16617 Pgk1 Phosphoglycerate kinase 1 Glycolysis - reversible reaction of 1,3-bisphosphoglycerate to 3-phosphoglycerate UP P16290 Pgam2 Phosphoglycerate mutase 2 Glycolysis - reversible...”
- Proteomic Expression Changes in Large Cerebral Arteries After Experimental Subarachnoid Hemorrhage in Rat Are Regulated by the MEK-ERK1/2 Pathway.
Müller, Journal of molecular neuroscience : MN 2017 - “...domain protein 1 1.17 P70619 Glutathione reductase (Fragment) 1.14 P24368 Peptidyl-prolyl cis-trans isomerase B 1.12 P38652 Phosphoglucomutase-1 1.07 P63326 40S ribosomal protein S10 1.06 Q5XI28 Ribonucleoprotein PTB-binding 1 1.05 Q9Z1P2 Alpha-actinin-1 1.05 B0BNF1 Septin-8 1.04 P97633 Casein kinase I isoform alpha 1.04 P63102 14-3-3 protein zeta/delta...”
- Acetaminophen Induced Hepatotoxicity in Wistar Rats--A Proteomic Approach.
Ilavenil, Molecules (Basel, Switzerland) 2016 - “...ribosomal protein L7 21 20 23 5.3 P37805 41 3823 Phosphoglucomutase 34 32 60.6 6.8 P38652 42 8705 Glutamate decarboxylase 36 34 60.5 9.2 P18088 Figure 5 Classification of differentially expressed proteins based on the localization. The identified proteins were classified according to their putative functions,...”
- Proteomic responses of skeletal and cardiac muscle to exercise.
Burniston, Expert review of proteomics 2011 - “...Glycogenolysis Alpha enolase P04764 [ 35 ] Beta enolase P13929 [ 44 ] Phosphoglucomutase 1 P38652 [ 35 ] Triosephosphate isomerase * P48500 [ 35 ] Muscle glycogen phosphorylase P09811 [ 43 ] Lactate dehydrogenase A P04642 [ 35 ] Tricarboxylic acid cycle Acontiase 2 Q63270...”
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PGM1 / P36871 phosphoglucomutase-1 (EC 5.4.2.2) from Homo sapiens (see 3 papers)
PGM1_HUMAN / P36871 Phosphoglucomutase-1; PGM 1; Glucose phosphomutase 1; EC 5.4.2.2 from Homo sapiens (Human) (see 8 papers)
P36871 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Homo sapiens (see 4 papers)
NP_002624 phosphoglucomutase-1 isoform 1 from Homo sapiens
27% identity, 67% coverage
- function: Catalyzes the reversible isomerization of alpha-D-glucose 1- phosphate to alpha-D-glucose 6-phosphate (PubMed:15378030, PubMed:25288802). The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate (Probable) (PubMed:25288802). This enzyme participates in both the breakdown and synthesis of glucose (PubMed:17924679, PubMed:25288802).
catalytic activity: alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate (RHEA:23536)
catalytic activity: O-phospho-L-seryl-[protein] + alpha-D-glucose 1-phosphate = alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] (RHEA:68748)
catalytic activity: alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] = O- phospho-L-seryl-[protein] + alpha-D-glucose 6-phosphate (RHEA:68752)
cofactor: Mg(2+) (Binds 1 Mg(2+) ion per subunit.)
subunit: Monomer. - Knock-down of PGM1 inhibits cell viability, glycolysis, and oxidative phosphorylation in glioma under low glucose condition via the Myc signaling pathway.
Liu, Biochemical and biophysical research communications 2023 (PubMed)- GeneRIF: Knock-down of PGM1 inhibits cell viability, glycolysis, and oxidative phosphorylation in glioma under low glucose condition via the Myc signaling pathway.
- Effects of the T337M and G391V disease-related variants on human phosphoglucomutase 1: structural disruptions large and small.
Stiers, Acta crystallographica. Section F, Structural biology communications 2022 - GeneRIF: Effects of the T337M and G391V disease-related variants on human phosphoglucomutase 1: structural disruptions large and small.
- Enzyme dysfunction at atomic resolution: Disease-associated variants of human phosphoglucomutase-1.
Beamer, Biochimie 2021 (PubMed)- GeneRIF: Enzyme dysfunction at atomic resolution: Disease-associated variants of human phosphoglucomutase-1.
- A missense variant remote from the active site impairs stability of human phosphoglucomutase 1.
Stiers, Journal of inherited metabolic disease 2020 (PubMed)- GeneRIF: A missense variant remote from the active site impairs stability of human phosphoglucomutase 1.
- AMPK-dependent phosphorylation of HDAC8 triggers PGM1 expression to promote lung cancer cell survival under glucose starvation.
Li, Cancer letters 2020 (PubMed)- GeneRIF: AMPK-dependent phosphorylation of HDAC8 triggers PGM1 expression to promote lung cancer cell survival under glucose starvation.
- Structural basis for substrate and product recognition in human phosphoglucomutase-1 (PGM1) isoform 2, a member of the α-D-phosphohexomutase superfamily.
Backe, Scientific reports 2020 - GeneRIF: Structural basis for substrate and product recognition in human phosphoglucomutase-1 (PGM1) isoform 2, a member of the alpha-D-phosphohexomutase superfamily.
- Congenital disorder of glycosylation type 1T with a novel truncated homozygous mutation in PGM1 gene and literature review.
Tian, Neuromuscular disorders : NMD 2019 (PubMed)- GeneRIF: c.405delT encodes a truncated protein with abnormal distribution and expression in skeletal muscle.
- The association between alcohol metabolism and genetic variants of ADH1A, SRPRB, and PGM1 in Korea.
Lee, Alcohol (Fayetteville, N.Y.) 2019 (PubMed)- GeneRIF: Variation in PGM-1 was associated with lower blood alcohol content in Korean subjects, suggesting likely involvement in alcohol metabolism and possible association with the development of alcohol-related diseases in Korea.
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- Combined High-Throughput Proteomics and Random Forest Machine-Learning Approach Differentiates and Classifies Metabolic, Immune, Signaling and ECM Intra-Tumor Heterogeneity of Colorectal Cancer
Contini, Cells 2024 - “...in S 0.0000 S<H >100 0.00001 P11177 ( PDHB ) PDHE1-B 0.0002 S<H >100 0.0005 P36871 ( PGM1 ) PGM-1 0.0009 S<H 3.2 0.3 qPCR, WB IHC [ 34 ] Q5T013 ( HYI) Putative Hyi ND in S 0.0007 S<H >100 Q9HD15 ( SRA1) SRA1 ND...”
- Novel Genetic and Biochemical Insights into the Spectrum of NEFL-Associated Phenotypes.
Della, Journal of neuromuscular diseases 2024 - “...anion-selective channel protein 1 (VDAC1_HUMAN) 0.54 0.000 P00558 26 Phosphoglycerate kinase 1 (PGK1_HUMAN) 0.54 0.039 P36871 29 Phosphoglucomutase-1 (PGM1_HUMAN) 0.54 0.012 Q9H6F2 3 Trimeric intracellular cation channel type A (TM38A_HUMAN) 0.54 0.016 P08559 8 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (ODPA_HUMAN) 0.54 0.000...”
- Ectopic pregnancy: search for biomarker in salivary proteome
Priya, Scientific reports 2023 - “...1 1 63. P28827 Receptor-type tyrosine-protein phosphatase mu PTPRM 1452 163,682 6.21 1 1 64. P36871 Phosphoglucomutase-1 PGM1 562 61,449 6.3 1 1 65. P36952 Serpin B5 SERPINB5 375 42,100 5.72 1 1 66. P37288 Vasopressin V1a receptor AVPR1A 418 46,800 9.48 1 1 67. P38646...”
- N-terminal proteoforms may engage in different protein complexes
Bogaert, Life science alliance 2023 - “...6A Yes CAD P27708; P31327 CAD protein Yes DPYSL2 Q16555 Dihydropyrimidinase-related protein 2 Yes PGM1 P36871 Phosphoglucomutase-1 Yes PKRKACB P22694 cAMP-dependent protein kinase catalytic subunit beta Yes PLK1 P53350 Serine/threonine protein kinase PLK1 Yes PRKDC P78527 DNA-dependent protein kinase catalytic subunit Yes PYGL P06737 Glycogen phosphorylase,...”
- Quantitative proteomic analysis of human serum using tandem mass tags to predict cardiovascular risks in patients with psoriasis.
Kim, Scientific reports 2023 - “...P00568 Adenylate kinase isoenzyme 1 AK1 1.584E02 2.537 P30086 Phosphatidylethanolamine-binding protein 1 PEBP1 3.199E02 2.461 P36871 Phosphoglucomutase-1 PGM1 1.386E02 2.429 P10720 Platelet factor 4 variant PF4V1 2.392E02 2.425 O75368 SH3 domain-binding glutamic acid-rich-like protein SH3BGRL 1.663E02 2.335 Q06481 Amyloid-like protein 2 APLP2 4.829E03 2.333 P14618 Pyruvate...”
- The Expression of Rab8, Ezrin, Radixin and Moesin in the Ciliary Body of Cynomolgus Monkeys.
Tanabe, Juntendo Iji zasshi = Juntendo medical journal 2022 - “...mitochondrial Q00325 40068.8 9.90 19 129 Phosphatidylethanolamine-binding protein 1 P30086 21043.7 27.30 11 130 Phosphoglucomutase-1 P36871 61410.6 5.70 3 131 Phosphoglycerate mutase 1 P18669 28785.9 31.50 12 132 Plasma membrane calcium-transporting ATPase 3 Q16720 134112.2 1.50 1 133 Plasminogen P00747 90510.2 2.10 1 134 Plectin-1 Q15149...”
- Raphe and ventrolateral medulla proteomics in epilepsy and sudden unexpected death in epilepsy.
Leitner, Brain communications 2022 - “...3.80E-04 2.41E-02 2.34E-04 1.30 LTA4H Leukotriene A-4 hydrolase P09960 4.18E-04 2.41E-02 2.59E-04 1.60 PGM1 Phosphoglucomutase-1 P36871 4.26E-04 2.41E-02 2.71E-04 1.63 Table 3 Top 20 differentially expressed proteins in dorsal raphe of PWE versus control Gene Protein UniProt ID ANOVA P -value ANOVA q value Tukey P...”
- The Effects of Mild Intermittent Hypoxia Exposure on the Abdominal Subcutaneous Adipose Tissue Proteome in Overweight and Obese Men: A First-in-Human Randomized, Single-Blind, and Cross-Over Study.
Van, Frontiers in physiology 2021 - “...NID2 Nidogen-2 0.60 0.019 0.387 18 P08294 SOD3 Extracellular superoxide dismutase 0.47 0.020 0.387 19 P36871 PGM1 Phosphoglucomutase-1 0.48 0.020 0.387 20 Q9BX68 HINT2 Histidine triad nucleotide-binding protein 2, mitochondrial 0.46 0.021 0.387 Figure 2 Heatmap of fold changes of differentially expressed proteins at a significance...”
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Q10DZ9 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) from Oryza sativa subsp. japonica
28% identity, 60% coverage
UAC_01121 phospho-sugar mutase from Enterococcus mundtii ATCC 882
26% identity, 83% coverage
CMU_003310 phosphoglucomutase/phosphomannomutase, C-terminal domain-containing protein from Cryptosporidium muris RN66
25% identity, 53% coverage
PGM_ENTH1 / O15820 Phosphoglucomutase; Glucose phosphomutase; EC 5.4.2.2 from Entamoeba histolytica (strain ATCC 30459 / HM-1:IMSS / ABRM) (see paper)
EHI_110120 phosphoglucomutase from Entamoeba histolytica HM-1:IMSS
25% identity, 74% coverage
- function: Catalyzes the reversible conversion of glucose 1-phosphate into glucose 6-phosphate (PubMed:9497037). This enzyme participates in both the breakdown and synthesis of glucose (PubMed:9497037).
catalytic activity: alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate (RHEA:23536)
cofactor: Mg(2+) (Binds 1 Mg(2+) ion per subunit.) - EhVps23, an ESCRT-I Member, Is a Key Factor in Secretion, Motility, Phagocytosis and Tissue Invasion by Entamoeba histolytica
Galindo, Frontiers in cellular and infection microbiology 2022 - “...protein EHI_098800 NAD(FAD)-dependent dehydrogenase EHI_099700 Uncharacterized protein EHI_101240 Filamin 2, putative EHI_104630 EhRab1A EHI_108610 Phosphoglucomutase EHI_110120 Myosin heavy chain EHI_110180 Uncharacterized protein EHI_118750 Enhancer binding protein-1 EHI_121780 MHD domain-containing protein EHI_124560 Rho family GTPase EHI_129750 Phosphopyruvate hydratase EHI_130700 Adenylate kinase EHI_135470 Adenylyl cyclase-associated protein EHI_136150 Rab...”
- Identification of the virulence landscape essential for Entamoeba histolytica invasion of the human colon
Thibeaux, PLoS pathogens 2013 - “...and -N-acetylhexosaminidase (EHI_148130) and 3 genes involved in the production of glucose-1-phosphate - glycogen phosphorylase (EHI_110120), 2 other alleles of -amylase (EHI_098200, EHI_148800), and UDP-glucose pyrophosphorylase (EHI_000440). Glycogen phosphorylase catalyses the rate-limiting step in glycogen degradation by releasing glucose-1-phosphate from the terminal -1,4-glycosidic bond, -amylase releases...”
AFUA_3G11830 phosphoglucomutase PgmA from Aspergillus fumigatus Af293
B0XXA2 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) from Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)
25% identity, 88% coverage
- Genetic validation of Aspergillus fumigatus phosphoglucomutase as a viable therapeutic target in invasive aspergillosis
Yan, The Journal of biological chemistry 2022 - “...active PGM enzyme Genomic annotation suggests that A.fumigatus possesses a gene coding for PGM (GenBank: AFUA_3G11830) although there is no experimental evidence to support this function ( 84 ). The pgm gene possesses two introns in the ORF. An intron-free ORF of pgm was amplified from...”
- “...using a hemocytometer. The construction of pgm conditional mutant strains A DNA fragment (Genbank ID: AFUA_3G11830, from -1091001 of pgm ) was amplified from A.fumigatus genomic DNA using primers P1 and P2 ( TableS5 ). The DNA fragment was cloned into the downstream region of the...”
- Effects of amino acids on the lignocellulose degradation by Aspergillus fumigatus Z5: insights into performance, transcriptional, and proteomic profiles
Miao, Biotechnology for biofuels 2019 - “...AFUA_6G14490, and AFUA_7G06140) in the proteome and transcriptome results remained consistent. Hexokinase (AFUA_2G05910, AFUA_7G04040), phosphoglucomutase (AFUA_3G11830), triosephosphate isomerase (AFUA_5G13450), phosphoglycerate mutase (AFUA_3G09290), phosphoglycerate kinase (AFUA_1G10350), enolase (AFUA_6G06770), and pyruvate kinase (AFUA_6G07430) also showed consistency between the two omics in the process of participating in glycolysis. In...”
- RNAseq analysis of Aspergillus fumigatus in blood reveals a just wait and see resting stage behavior
Irmer, BMC genomics 2015 - “...synthase Gsy1), AFUA_2G13850 (protein phosphatase regulatory subunit Gac1), and trehalose biogenesis AFUA_2G04010 (alpha,alpha-trehalose-phosphate synthase). Also AFUA_3G11830 (phosphoglucomutase PgmA) is down-regulated at B180s which is involved in glycolysis as well as glycogen and trehalose biogenesis [ 61 ]. Mitotic cell cycle and cell cycle control The category...”
- Conservation of nucleosome positions in duplicated and orthologous gene pairs
Nishida, TheScientificWorldJournal 2012 - “...AFUA_5G12810 0.002517201 YNR015W AFUA_3G08390 0.013154917 YBR251W AFUA_5G11540 0.01637247 YHL028W AFUA_5G09020 0.020657813 YPL146C AFUA_2G05550 0.023787247 YKL127W AFUA_3G11830 0.026619404 YJR160C AFUA_2G10910 0.029508087 YIR038C AFUA_1G17010 0.030714781 YDL247W AFUA_2G10910 0.033905332 YBR204C AFUA_1G03540 0.038361835 YJR010W AFUA_3G06530 0.038908707 YMR210W AFUA_6G04640 0.046477426 YPR187W AFUA_1G05160 0.048502572 YDR037W AFUA_6G07640 0.052027721 YIL134W AFUA_6G05170 0.053118026 YLR286C AFUA_5G03760...”
- The Aspergillus fumigatus transcriptional regulator AfYap1 represents the major regulator for defense against reactive oxygen intermediates but is dispensable for pathogenicity in an intranasal mouse infection model
Lessing, Eukaryotic cell 2007 - “...(AFUA_1G13500) .....................................2.04 Phosphoglucomutase PgmA (AFUA_3G11830) .......................1.67 Purine and pyrimidine synthesis GMP...”
- A murine inhalation model to characterize pulmonary exposure to dry Aspergillus fumigatus conidia
Buskirk, PloS one 2014 - “...9.91 3 a) Putative, Mitochondrial dihydroxy acid dehydratase B0XTT1 68.21/7.78 10 13.08 b) Phosphoglucomutase PgmA B0XXA2 60.46/6.30 14 16.58 c) Putative, Pyruvate decarboxylase PdcA B0XXN9 62.96/6.07 3 10.72 d) Putative, GMC oxidoreductase Q4WFN7 72.10/7.08 3 7.58 4 a) Putative, Antigenic mitochondrial protein HSP60 B0XRX3 61.91/5.35 35...”
A0A2H5BEG8 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Ganoderma lucidum (see paper)
26% identity, 80% coverage
7p5oB / Q4WY53 Crystal structure of aspergillus fumigatus phosphoglucomutase in complex with the reaction intermediate
25% identity, 87% coverage
- Ligands: 1,6-di-o-phosphono-alpha-d-glucopyranose; magnesium ion (7p5oB)
A8N8Z1 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Coprinopsis cinerea (see paper)
26% identity, 78% coverage
Q980S1 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2); phosphomannomutase (EC 5.4.2.8) from Saccharolobus solfataricus (see paper)
SSO0207 Phosphomannomutase (pmM) from Sulfolobus solfataricus P2
SSO0207 phosphoglucosamine mutase from Saccharolobus solfataricus P2
22% identity, 92% coverage
- The biology of thermoacidophilic archaea from the order Sulfolobales
Lewis, FEMS microbiology reviews 2021 - “...of ADP-ribose (Haile and Kennelly 2011). Phosphohexomutase (SSO0207), first identified in tryptic digests, was shown to be phosphorylated. Sitedirected...”
- “...DNA repair (Huang et al. 2019). The phosphohexomutase (SSO0207) exhibited a decreased Vmax value after being phosphorylated (Ray et al. 2005). The Rio kinases...”
- Protein phosphorylation and its role in archaeal signal transduction
Esser, FEMS microbiology reviews 2016 (no snippet) - Carbohydrate metabolism in Archaea: current insights into unusual enzymes and pathways and their regulation
Bräsen, Microbiology and molecular biology reviews : MMBR 2014 - “...PGK (SSO0527), FBPA/ase (SSO3226), PGI (SSO2281), and PGM (SSO0207) in complex medium. The upregulation of most enzymes seems to be reasonable in order to...”
- Global analysis of viral infection in an archaeal model system
Maaty, Frontiers in microbiology 2012 - “...and metabolism Uracil phosphoribosyltransferase, SSO0231 (48), Glutamine amidotransferase, SSO0571 (72) Carbohydrate transport and metabolism Phosphomannomutase, SSO0207 (12, 24)(48), phosphoenolpyruvate synthase, SSO0883 (12,24); bifunctional phosphoglucose/phosphomannose isomerase, SSO2281(72); ABC transporter, SSO2850 (72); Fructokinase, SSO3195 (36, 48) Lipid transport and metabolism Acetyl-CoA acetyltransferase, SSO2061 (12, 24)(48), Lipase, SSO2493 (36,48),...”
- “...phosphorylation has only been described for a few Sulfolobus proteins. Interestingly, one of these, phosphohexomutase (SSO0207; Ray et al., 2005 ) was among the regulated proteins. Phosphohexomutase was found in six different gel spots and exhibited a complex pattern of regulation (Figure 2 B). Rubrerythrin, the...”
- Ser/Thr/Tyr protein phosphorylation in the archaeon Halobacterium salinarum--a representative of the third domain of life
Aivaliotis, PloS one 2009 - “...about the cellular impact of this phosphorylation, except of the case of a putative phosphohexomutase (sso0207) from S. solfataricus P2, in which the in vivo phosphorylation of Ser309 seems to regulate its catalytic activity [31] . In addition, in phosphorylation site database ( http://vigen.biochem.vt.edu/xpd/xpdindex.htm ), [32]...”
- “...7 records were found for protein phosphorylation in archaea, including the previously mentioned putative phosphohexomutase (sso0207) from S. solfataricus P2; Beta-1 subunit of 20S proteasome, psmB1, from H. volcanii [29] ; cell division control protein 6, homologs 1 and 2, mthCdc6-1 and mthCdc6-2, respectively, from Methanothermobacter...”
- Identification and characterization of an ATP-dependent hexokinase with broad substrate specificity from the hyperthermophilic archaeon Sulfolobus tokodaii
Nishimasu, Journal of bacteriology 2006 - “...uridylyltransferase activities (35). Moreover, phosphohexomutase (SSO0207) from S. solfataricus (25) and glycogen synthase from S. acidocaldarius...”
- A phosphohexomutase from the archaeon Sulfolobus solfataricus is covalently modified by phosphorylation on serine
Ray, Journal of bacteriology 2005 - “...the predicted protein product of open reading frame sso0207, a putative phosphohexomutase, in the genome of S. solfataricus P2. Open reading frame sso0207 was...”
- “...event in the protein product of ORF sso0207, a putative phosphohexomutase, that inhibits its catalytic activity. (Pittsburgh, PA). Chelating Sepharose Fast-Flow...”
PmVP161_0089 phospho-sugar mutase from Pasteurella multocida
25% identity, 87% coverage
NCU10058 phosphoglucomutase 2 from Neurospora crassa OR74A
25% identity, 90% coverage
- Uncovering in vivo biochemical patterns from time-series metabolic dynamics
Wu, PloS one 2022 - “...our working hypothesis is that the metabolic associations with G1P depend on phosphoglucomutase (gene id: NCU10058 ) and its reversible connection to glycolysis. In the future, we will test the effects of its mutants (strain id: FGSC #18976) on central energy metabolism. We also found that...”
- Histone H3 lysine 4 methyltransferase is required for facultative heterochromatin at specific loci
Zhu, BMC genomics 2019 - “...mechanisms affecting expression. A typical example of this occurred in a region containing three genes (NCU10058, NCU10059 and NCU16377) located between 2 constitutive heterochromatin domains (Fig. 5 b). In this instance, all 3 genes had a reduction in H3K4me3 levels in kmt1/dim5 and all had a...”
- “...c ) The expression level of the three genes is represented as bar plots for NCU10058, NCU10059 and NCU16377 in WT, kmt2/ set-1 and kmt1/ dim-5 comparing expression in DD (grey) versus LP30 (black) We next focused on genes with a co-dependent and overlapping relationship between...”
B4DFP1 Phosphoglucomutase-1 from Homo sapiens
27% identity, 69% coverage
XP_003592358 phosphoglucomutase, chloroplastic from Medicago truncatula
24% identity, 62% coverage
- Plastidial Phosphoglucomutase (pPGM) Overexpression Increases the Starch Content of Transgenic Sweet Potato Storage Roots
Wang, Genes 2022 - “...A. thaliana , AF216580; Gossypium hirsutum , XM_016881887; Manihot esculenta , XP_021616975; Medicago truncatula , XP_003592358; P. sativum , AJ250770; Coffea arabica , XP_027103885; Solanum lycopersicum , XP_004234144; S. tuberosum , NM_001288352; A. thaliana , At1g23190; P. sativum , AJ250769; Sesamum indicum , XP_011070593; Oryza sativa...”
Q4QCF1 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Leishmania major (see paper)
26% identity, 86% coverage
- Biology, Mechanism, and Structure of Enzymes in the α-d-Phosphohexomutase Superfamily.
Stiers, Advances in protein chemistry and structural biology 2017 - “...T. thermophilus bacterial Q5SLE0 2Z0F 524 2.52 N No (pH 5.4) dimer L. minor bacterial Q4QCF1 4QG5 589 3.50 Mg H. sapiens eukaryote P36871 5EPC, 5F9C, 5HSH 562 1.85 N Mg O. cuniculus eukaryote P00949 3PMG, 1VKL, 1JDY, 1LXT, 1C4G, 1C47 561 2.40 Y/N Mg, Ni,...”
CCA00344 phosphoglucomutase/phosphomannomutase family protein from Chlamydophila caviae GPIC
24% identity, 76% coverage
- CT295 Is <i>Chlamydia trachomatis'</i> Phosphoglucomutase and a Type 3 Secretion Substrate
Triboulet, Frontiers in cellular and infection microbiology 2022 - “...and after testing the orthologous protein in different Chlamydiaceae we chose the C. caviae ortholog, CCA00344, which displayed 59% amino acid identity with CT295. CCA00344-HIS and CT815-HIS were purified from E. coli extracts ( Figure3 and Figure S1A ). As a positive control we also produced...”
- “...The substrates and reaction products were identified by HPAEC. Incubation of Glc1P (peak c) with CCA00344 resulted in full conversion into Glc6P (peaks a and b), while Glc6P was hardly detectable when CT815 was tested. Note that the samples were run on two different columns, resulting...”
G0Z3A1 Phosphoglucomutase-1 from Sus scrofa
26% identity, 69% coverage
LOC110729741 phosphoglucomutase, chloroplastic-like from Chenopodium quinoa
24% identity, 69% coverage
- Integrating transcriptomics and metabolomics to analyze quinoa (Chenopodium quinoa Willd.) responses to drought stress and rewatering
Huan, Frontiers in plant science 2022 - “...LOC110689796 gene (sucrose synthase, EC: 2.4.1.13), were up-regulated during drought, but down-regulated after rehydration. The LOC110729741 gene (phosphoglucomutase, EC: 5.4.2.2) was down-regulated during drought but stabilized after rehydration. The LOC110719410 gene (ADP-sugar diphosphatase, EC: 3.6.1.21) was up-regulated during dry drought but stabilized after rehydration. The LOC110683757...”
- “...sucrose synthase) including the LOC110689796 gene promoted the down-regulation of sucrose. The down-regulation of the LOC110729741 gene (EC: 5.4.2.2, phosphoglucomutase) was associated with that of D-glucose-6P. Up-regulation of the LOC110719410 gene (EC: 3.6.1.21, ADP sugar diphosphatase) promoted the down regulation of -D-glucose-1P. Down-regulation of the LOC110703195...”
XP_027103885 phosphoglucomutase, chloroplastic-like from Coffea arabica
25% identity, 61% coverage
- Plastidial Phosphoglucomutase (pPGM) Overexpression Increases the Starch Content of Transgenic Sweet Potato Storage Roots
Wang, Genes 2022 - “...Manihot esculenta , XP_021616975; Medicago truncatula , XP_003592358; P. sativum , AJ250770; Coffea arabica , XP_027103885; Solanum lycopersicum , XP_004234144; S. tuberosum , NM_001288352; A. thaliana , At1g23190; P. sativum , AJ250769; Sesamum indicum , XP_011070593; Oryza sativa , XP_015632142; Sorghum bicolor , XP_002466576; Z. mays...”
SM12261_RS05265 phospho-sugar mutase from Streptococcus mitis NCTC 12261
24% identity, 84% coverage
FD735_RS05500 phospho-sugar mutase from Streptococcus sp. 1643
23% identity, 86% coverage
SGO_1215 phosphomannomutase from Streptococcus gordonii str. Challis substr. CH1
23% identity, 84% coverage
- Streptococcus gordonii Type I Lipoteichoic Acid Contributes to Surface Protein Biogenesis
Lima, mSphere 2019 - “...Pbp1a SGO_0586 Penicillin-binding protein 1A Pbp2a SGO_2010 Penicillin-binding protein 2A PgdA SGO_0948 Peptidoglycan-N-acetylglucosamine deacetylase ManB SGO_1215 Phosphoglucomutase SGO_1149 Pneumococcal vaccine antigen A-like protein SGO_0457 Polar amino acid transport system substrate-binding protein Wzd SGO_2016 Polysaccharide export protein Bta SGO_1216 Possible bacteriocin transport accessory protein SGO_0599 PPM family...”
PGM_EMENI / Q9P931 Phosphoglucomutase; PGM; Glucose phosphomutase; EC 5.4.2.2 from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) (see paper)
pgmB phosphoglucomutase; EC 5.4.2.2 from Emericella nidulans (see paper)
25% identity, 91% coverage
- function: Catalyzes the reversible isomerization of alpha-D-glucose 1- phosphate to alpha-D-glucose 6-phosphate (PubMed:10660061). The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6- bisphosphate (By similarity). Key enzyme in hexose metabolism (By similarity). The reverse reaction is an essential step for biosynthesis because glucose 1-phosphate is the starting point for the synthesis of UDP-glucose, which acts as a precursor for the synthesis of oligosaccharides and trehalose (By similarity).
catalytic activity: alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate (RHEA:23536)
catalytic activity: O-phospho-L-seryl-[protein] + alpha-D-glucose 1-phosphate = alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] (RHEA:68748)
catalytic activity: alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] = O- phospho-L-seryl-[protein] + alpha-D-glucose 6-phosphate (RHEA:68752)
cofactor: Mg(2+) (Binds 1 Mg(2+) ion per subunit.)
subunit: Monomer. - CharProtDB Description: Putative phosphoglucomutase with a predicted role in carbohydrate metabolism; transcript levels increase during asexual development; Source:AspGD
7s0wB / P36871 Crystal structure of the t337m variant of human pgm-1 (see paper)
28% identity, 66% coverage
- Ligand: cobalt (ii) ion (7s0wB)
4qg5A / Q4QCF1 Crystal structure of phosphoglucomutase from leishmania major at 3.5 angstrom resolution
26% identity, 82% coverage
- Ligand: magnesium ion (4qg5A)
HMPREF8579_1344 phospho-sugar mutase from Streptococcus oralis ATCC 35037
23% identity, 84% coverage
ZP_01818094 phosphoglucomutase/phosphomannomutase family protein from Streptococcus pneumoniae SP3-BS71
23% identity, 84% coverage
PGM_SCHPO / O74374 Phosphoglucomutase; PGM; Glucose phosphomutase; EC 5.4.2.2 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
SPBC32F12.10 phosphoglucomutase (predicted) from Schizosaccharomyces pombe
27% identity, 70% coverage
- function: Catalyzes the reversible isomerization of alpha-D-glucose 1- phosphate to alpha-D-glucose 6-phosphate (By similarity). The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate (By similarity). Key enzyme in hexose metabolism (By similarity). The reverse reaction is an essential step for biosynthesis because glucose 1-phosphate is the starting point for the synthesis of UDP-glucose, which acts as a precursor for the synthesis of oligosaccharides and trehalose (By similarity).
catalytic activity: alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate (RHEA:23536)
catalytic activity: O-phospho-L-seryl-[protein] + alpha-D-glucose 1-phosphate = alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] (RHEA:68748)
catalytic activity: alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] = O- phospho-L-seryl-[protein] + alpha-D-glucose 6-phosphate (RHEA:68752)
cofactor: Mg(2+) (Binds 1 Mg(2+) ion per subunit.)
subunit: Monomer. - Divergence of a conserved elongation factor and transcription regulation in budding and fission yeast
Booth, Genome research 2016 - “...Fig. 2 B). Visualization of PRO-seq density for representative genes, YBR078W in S. cerevisiae and SPBC32F12.10 in S. pombe , illustrates these same characteristics ( Fig. 2 C,D). Regarding intronexon junctions, Pol II density around fission yeast splice sites exhibited features similar to those described in...”
- Characterization of genome-reduced fission yeast strains
Sasaki, Nucleic acids research 2013 - “...However, the transcriptome analyses (described later in the text) showed gene expression of the phosphoglucomutases, SPBC32F12.10 and SPCC1840.05c, which convert - d -glucose 6-phosphate to - d -glucose 1-phosphate, to be almost equal to that of ASP3880 ( Figure 4 ). UTP-glucose-1-phosphate uridylyltransferase genes, SPCC1322.04/ fyu1...”
- DNA sequencing and analysis of a 40 kb region from the right arm of chromosome II from Schizosaccharomyces pombe
Sánchez, Yeast (Chichester, England) 1999 (PubMed)- “...human neutral sphingomyelinase, whereas SPBC32F12.03c, SPBC32F12.10 and SPBC32F12.14 exhibit strong homology to glutathione peroxidase, phosphoglucomutase and...”
- “...led to two different amino acids (I72<M and V73<L). SPBC32F12.10. This ORF encodes a protein of 60*6 kDa which exhibits extensive sequence similarity over its...”
Q9RP94 Phosphoglucomutase from Streptococcus pneumoniae
23% identity, 84% coverage
B7GE51 UDP-Glucose-Pyrophosphorylase/Phosphoglucomutase from Phaeodactylum tricornutum (strain CCAP 1055/1)
27% identity, 37% coverage
spr1351 Phosphoglucomutase from Streptococcus pneumoniae R6
SP_1498 phosphoglucomutase from Streptococcus pneumoniae TIGR4
SPD_1326 phosphoglucomutase/phosphomannomutase family protein from Streptococcus pneumoniae D39
23% identity, 84% coverage
- Location, synthesis and function of glycolipids and polyglycerolphosphate lipoteichoic acid in Gram-positive bacteria of the phylum Firmicutes
Reichmann, FEMS microbiology letters 2011 - “...manner as in L. monocytogenes , requiring the production of UDP-Glc by the phosphoglucomutase Pgm (Spr1351) and uridyltransferase GalU (Spr1903) ( Mollerach et al. , 1998 ; Hardy et al. , 2001 ) ( Fig. 2d ). For GalGlc-DAG production, the transfer of the second sugar...”
- A new variant of the capsule 3 cluster occurs in Streptococcus pneumoniae from deceased wild chimpanzees
Denapaite, PloS one 2011 - “...cluster [35] . Since S. pneumoniae R6 contains pgm 2 and galU 2 corresponding to spr1351 and spr1903, respectively, their functions were expected to complement the enzymatic machinery required for CPS3 synthesis. The ligation mixture was used as donor DNA, since wildtype colonies resulting from transformation...”
- A genome-wide atlas of antibiotic susceptibility targets and pathways to tolerance
Leshchiner, Nature communications 2022 - “...on fitness in all CWSIs and a negative effect in 30S PSIs. In contrast, inhibiting SP_1498 ( pgm , phosphoglucomutase), the major interconversion enzyme of G-6P and G-1P, has a negative effect on fitness with all antibiotics (Fig. 3c ). Additional detailed examples are highlighted in...”
- Streptococcus pneumoniae, S. mitis, and S. oralis Produce a Phosphatidylglycerol-Dependent, ltaS-Independent Glycerophosphate-Linked Glycolipid
Wei, mSphere 2021 - “...AA UDP-Glc -Phosphoglucomutase ( pgm ) ( 44 ) SM12261_RS05265 98.6 HMPREF8579_1344 97.0 FD735_RS05500 97.2 SP_1498 100.0 UTP: -glucose-1-phosphate uridyltransferase ( galU ) ( 44 ) SM12261_RS05330 95.3 HMPREF8579_0527 93.7 FD735_RS00655 93.7 SP_2092 95.7 UDP-Gal Galactokinase ( galK ) ( 46 ) SM12261_RS02220 97.2 HMPREF8579_1824 95.7...”
- Identification of Streptococcus pneumoniae genes associated with hypothiocyanous acid tolerance through genome-wide screening
Shearer, Journal of bacteriology 2023 (secret) - Cellular Mn/Zn Ratio Influences Phosphoglucomutase Activity and Capsule Production in Streptococcus pneumoniae D39
McFarland, Journal of bacteriology 2021 (secret) - Proteomic Investigation Uncovers Potential Targets and Target Sites of Pneumococcal Serine-Threonine Kinase StkP and Phosphatase PhpP
Hirschfeld, Frontiers in microbiology 2019 - “...ASTSQQNETIASQNAAASQTQAEIGNLI S 182 Q T 184 EAK Competence factor transport protein ComB Two-component system ** SPD_1326 HLN C FAGIMVTA S 144 HNPAPFNGYK Phosphogluco/mannomutase family protein Pgm Glycolysis/Gluconeogenesis * SPD_1326 HLN C FAGIMV T 142 ASHNPAPFNGYK Phosphogluco/mannomutase family protein Pgm Glycolysis/Gluconeogenesis * SPD_0790 AICEE T 238 GNGHVQLFAK...”
LBA0687 phosphoglucomutase from Lactobacillus acidophilus NCFM
24% identity, 84% coverage
SCO4916 phosphomannomutase from Streptomyces coelicolor A3(2)
25% identity, 88% coverage
NCLIV_014450 Phosphoglucomutase 2, related from Neospora caninum Liverpool
23% identity, 53% coverage
XP_004234144 phosphoglucomutase, chloroplastic from Solanum lycopersicum
25% identity, 62% coverage
- Plastidial Phosphoglucomutase (pPGM) Overexpression Increases the Starch Content of Transgenic Sweet Potato Storage Roots
Wang, Genes 2022 - “...Medicago truncatula , XP_003592358; P. sativum , AJ250770; Coffea arabica , XP_027103885; Solanum lycopersicum , XP_004234144; S. tuberosum , NM_001288352; A. thaliana , At1g23190; P. sativum , AJ250769; Sesamum indicum , XP_011070593; Oryza sativa , XP_015632142; Sorghum bicolor , XP_002466576; Z. mays , U89341; S. cerevisiae...”
XP_021616975 phosphoglucomutase, chloroplastic isoform X2 from Manihot esculenta
24% identity, 63% coverage
- Plastidial Phosphoglucomutase (pPGM) Overexpression Increases the Starch Content of Transgenic Sweet Potato Storage Roots
Wang, Genes 2022 - “...Brassica rapa , XP_009107139; A. thaliana , AF216580; Gossypium hirsutum , XM_016881887; Manihot esculenta , XP_021616975; Medicago truncatula , XP_003592358; P. sativum , AJ250770; Coffea arabica , XP_027103885; Solanum lycopersicum , XP_004234144; S. tuberosum , NM_001288352; A. thaliana , At1g23190; P. sativum , AJ250769; Sesamum indicum...”
SAK_0594 phosphoglucomutase/phosphomannomutase family protein from Streptococcus agalactiae A909
25% identity, 85% coverage
XP_009107139 phosphoglucomutase, chloroplastic isoform X2 from Brassica rapa
25% identity, 62% coverage
Rv3308 PROBABLE PHOSPHOMANNOMUTASE PMMB (PHOSPHOMANNOSE MUTASE) from Mycobacterium tuberculosis H37Rv
27% identity, 92% coverage
- Telacebec Interferes with Virulence Lipid Biosynthesis Protein Expression and Sensitizes to Other Antibiotics
Zhou, Microorganisms 2023 - “...0.01965 0.664403424 Metabolic pathways Rv0211 PckA Phosphoenolpyruvate carboxykinase 0.00217 1.294218998 Rv0620 GalK Galactokinase 0.01055 0.566918099 Rv3308 PmmB Phosphomannomutase; converts D-mannose 1-phosphate to D-mannose 6-phosphate 0.0301 0.196754059 Rv3600c NA Type III pantothenate kinase catalyzing the phosphorylation of pantothenate, the first step in CoA biosynthesis 0.04899 0.086255116 Rv1589...”
- Host- and Age-Dependent Transcriptional Changes in Mycobacterium tuberculosis Cell Envelope Biosynthesis Genes after Exposure to Human Alveolar Lining Fluid
Allué-Guardia, International journal of molecular sciences 2022 - “...(previously annotated as manC ), pmmA / Rv3257c (previously annotated as manB ), pmmB / Rv3308 ) and polyprenylphosphate-based mannose or PPM ( pmm1 / Rv2051c ), the transcriptional regulator whiB2/Rv3260c [ 26 ], and mannosyl ( pimA / Rv2610c , pimB / Rv2188c , pimF...”
- “...formation of Man-1-P pmmA-F: GATCACGTTGTGGATGATGG pmmA-R: GTGGATCTGCAGGCCTATGT 60 60 [ 26 ] [ 27 ] Rv3308 pmmB phosphomannose mutase/GDP-Man biosynthesis: formation of Man-1-P pmmB-F: ATACAGATCACGGCGTCACA pmmB-R: CGCTGGATATAACGGTCGAT 60 60 [ 27 ] [ 27 ] Rv2051c ppm1 Polyprenol-monophosphomannose synthase/PPM biosynthesis pmm1-F: TGGTTGAAGTCGATCCTTCC pmm1-R: GCGAACAAGACCAGGCATATG 60 63...”
- Host- and age-dependent transcriptional changes in Mycobacterium tuberculosis cell envelope biosynthesis genes after exposure to human alveolar lining fluid
Allué-Guardia, 2021 - Dissecting the antibacterial activity of oxadiazolone-core derivatives against Mycobacterium abscessus
Madani, PloS one 2020 - “...54.339 Rv2045c - Carboxylesterase LipT IM/R MAB_3398 17.635 Rv3178 - uncharacterized protein - MAB_3661 57.093 Rv3308 M Probable phosphomannomutase PmmB IM/R MAB_3689 26.374 Rv3342 WCL Possible methyltransferase IM/R MAB_3705 19.995 Rv2506 CF/M Putative TetR family regulatory protein RP MAB_4103c 30.192 Rv1523 - Probable methyltransferase IM/R MAB_4201c...”
- Genomic epidemiology of multidrug-resistant Mycobacterium tuberculosis during transcontinental spread
Coscolla, The Journal of infectious diseases 2015 - “...dfrA ugpE C G Rv3201c V399L 3 575 842 ... G G A A Rv3308 Rv3415c G233D A16V 3 695 561 3 834 475 pmmB ... G T Rv3447c S1233R 3 864 540 ... G T C C Rv3596c Rv3735...”
- Characterization of host and microbial determinants in individuals with latent tuberculosis infection using a human granuloma model
Guirado, mBio 2015 - “.../phosphomannomutase (Rv3257c) Mannose 6P to mannose 1P Mannose donor biosynthesis pathway 9.3 9.6* pmmB /phosphomannomutase (Rv3308) Mannose 6P to mannose 1P Mannose donor biosynthesis pathway 0.95 1.012** mrsA /phosphomannomutase (Rv3441c) Mannose 6P to mannose 1P Mannose donor biosynthesis pathway 0.91 1.18 pgmA /phosphomannomutase (Rv3068c) Mannose 6P...”
- Comparative transcriptional study of the putative mannose donor biosynthesis genes in virulent Mycobacterium tuberculosis and attenuated Mycobacterium bovis BCG strains
Keiser, Infection and immunity 2011 - “...manC ACATCGCCGTTAAACACCAT (forward) GTTCCTCACCCATCTGCTGT (reverse) Rv3308, BCG_3373 pmmB ATACAGATCACGGCGTCACA (forward) CGCTGGATATAACGGTCGAT (reverse) a Each...”
- Lipoglycans contribute to innate immune detection of mycobacteria
Krishna, PloS one 2011 - “...Construction of the M. smegmatis recombinant strains Rv3255c ( manA ), Rv3257c ( manB ), Rv3308 ( pmmB ) and Rv3264c ( manC ) genes were amplified from M. tuberculosis H37Rv genomic DNA (TB Vaccine Testing and Research Materials Contract, NIH, NIAID NO1-AI-40091) using the primers...”
- “...and EcoRV ( Rv3255c and Rv3264c) , Bal I ( Rv3257c) and SmaI for ( Rv3308) on the other hand. Restricted PCR products were ligated into the BalI and HindIII-digested pMV261 E. coli -mycobacteria shuttle vector [23] , giving rise to the pMV manA , pMV...”
- More
D7T1T9 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) from Vitis vinifera
25% identity, 81% coverage
SAV_3343 phosphomannomutase from Streptomyces avermitilis MA-4680
25% identity, 88% coverage
For advice on how to use these tools together, see
Interactive tools for functional annotation of bacterial genomes.
The PaperBLAST database links 789,361 different protein sequences to 1,256,019 scientific articles. Searches against EuropePMC were last performed on January 10 2025.
PaperBLAST builds a database of protein sequences that are linked
to scientific articles. These links come from automated text searches
against the articles in EuropePMC
and from manually-curated information from GeneRIF, UniProtKB/Swiss-Prot,
BRENDA,
CAZy (as made available by dbCAN),
BioLiP,
CharProtDB,
MetaCyc,
EcoCyc,
TCDB,
REBASE,
the Fitness Browser,
and a subset of the European Nucleotide Archive with the /experiment tag.
Given this database and a protein sequence query,
PaperBLAST uses protein-protein BLAST
to find similar sequences with E < 0.001.
To build the database, we query EuropePMC with locus tags, with RefSeq protein
identifiers, and with UniProt
accessions. We obtain the locus tags from RefSeq or from MicrobesOnline. We use
queries of the form "locus_tag AND genus_name" to try to ensure that
the paper is actually discussing that gene. Because EuropePMC indexes
most recent biomedical papers, even if they are not open access, some
of the links may be to papers that you cannot read or that our
computers cannot read. We query each of these identifiers that
appears in the open access part of EuropePMC, as well as every locus
tag that appears in the 500 most-referenced genomes, so that a gene
may appear in the PaperBLAST results even though none of the papers
that mention it are open access. We also incorporate text-mined links
from EuropePMC that link open access articles to UniProt or RefSeq
identifiers. (This yields some additional links because EuropePMC
uses different heuristics for their text mining than we do.)
For every article that mentions a locus tag, a RefSeq protein
identifier, or a UniProt accession, we try to select one or two
snippets of text that refer to the protein. If we cannot get access to
the full text, we try to select a snippet from the abstract, but
unfortunately, unique identifiers such as locus tags are rarely
provided in abstracts.
PaperBLAST also incorporates manually-curated protein functions:
- Proteins from NCBI's RefSeq are included if a
GeneRIF
entry links the gene to an article in
PubMed®.
GeneRIF also provides a short summary of the article's claim about the
protein, which is shown instead of a snippet.
- Proteins from Swiss-Prot (the curated part of UniProt)
are included if the curators
identified experimental evidence for the protein's function (evidence
code ECO:0000269). For these proteins, the fields of the Swiss-Prot entry that
describe the protein's function are shown (with bold headings).
- Proteins from BRENDA,
a curated database of enzymes, are included if they are linked to a paper in PubMed
and their full sequence is known.
- Every protein from the non-redundant subset of
BioLiP,
a database
of ligand-binding sites and catalytic residues in protein structures, is included. Since BioLiP itself
does not include descriptions of the proteins, those are taken from the
Protein Data Bank.
Descriptions from PDB rely on the original submitter of the
structure and cannot be updated by others, so they may be less reliable.
(For SitesBLAST and Sites on a Tree, we use a larger subset of BioLiP so that every
ligand is represented among a group of structures with similar sequences, but for
PaperBLAST, we use the non-redundant set provided by BioLiP.)
- Every protein from EcoCyc, a curated
database of the proteins in Escherichia coli K-12, is included, regardless
of whether they are characterized or not.
- Proteins from the MetaCyc metabolic pathway database
are included if they are linked to a paper in PubMed and their full sequence is known.
- Proteins from the Transport Classification Database (TCDB)
are included if they have known substrate(s), have reference(s),
and are not described as uncharacterized or putative.
(Some of the references are not visible on the PaperBLAST web site.)
- Every protein from CharProtDB,
a database of experimentally characterized protein annotations, is included.
- Proteins from the CAZy database of carbohydrate-active enzymes
are included if they are associated with an Enzyme Classification number.
Even though CAZy does not provide links from individual protein sequences to papers,
these should all be experimentally-characterized proteins.
- Proteins from the REBASE database
of restriction enzymes are included if they have known specificity.
- Every protein with an evidence-based reannotation (based on mutant phenotypes)
in the Fitness Browser is included.
- Sequence-specific transcription factors (including sigma factors and DNA-binding response regulators)
with experimentally-determined DNA binding sites from the
PRODORIC database of gene regulation in prokaryotes.
- Putative transcription factors from RegPrecise
that have manually-curated predictions for their binding sites. These predictions are based on
conserved putative regulatory sites across genomes that contain similar transcription factors,
so PaperBLAST clusters the TFs at 70% identity and retains just one member of each cluster.
- Coding sequence (CDS) features from the
European Nucleotide Archive (ENA)
are included if the /experiment tag is set (implying that there is experimental evidence for the annotation),
the nucleotide entry links to paper(s) in PubMed,
and the nucleotide entry is from the STD data class
(implying that these are targeted annotated sequences, not from shotgun sequencing).
Also, to filter out genes whose transcription or translation was detected, but whose function
was not studied, nucleotide entries or papers with more than 25 such proteins are excluded.
Descriptions from ENA rely on the original submitter of the
sequence and cannot be updated by others, so they may be less reliable.
Except for GeneRIF and ENA,
the curated entries include a short curated
description of the protein's function.
For entries from BioLiP, the protein's function may not be known beyond binding to the ligand.
Many of these entries also link to articles in PubMed.
For more information see the
PaperBLAST paper (mSystems 2017)
or the code.
You can download PaperBLAST's database here.
Changes to PaperBLAST since the paper was written:
- November 2023: incorporated PRODORIC and RegPrecise. Many PRODORIC entries were not linked to a protein sequence (no UniProt identifier), so we added this information.
- February 2023: BioLiP changed their download format. PaperBLAST now includes their non-redundant subset. SitesBLAST and Sites on a Tree use a larger non-redundant subset that ensures that every ligand is represented within each cluster. This should ensure that every binding site is represented.
- June 2022: incorporated some coding sequences from ENA with the /experiment tag.
- March 2022: incorporated BioLiP.
- April 2020: incorporated TCDB.
- April 2019: EuropePMC now returns table entries in their search results. This has expanded PaperBLAST's database, but most of the new entries are of low relevance, and the resulting snippets are often just lists of locus tags with annotations.
- February 2018: the alignment page reports the conservation of the hit's functional sites (if available from from Swiss-Prot or UniProt)
- January 2018: incorporated BRENDA.
- December 2017: incorporated MetaCyc, CharProtDB, CAZy, REBASE, and the reannotations from the Fitness Browser.
- September 2017: EuropePMC no longer returns some table entries in their search results. This has shrunk PaperBLAST's database, but has also reduced the number of low-relevance hits.
Many of these changes are described in Interactive tools for functional annotation of bacterial genomes.
PaperBLAST cannot provide snippets for many of the papers that are
published in non-open-access journals. This limitation applies even if
the paper is marked as "free" on the publisher's web site and is
available in PubmedCentral or EuropePMC. If a journal that you publish
in is marked as "secret," please consider publishing elsewhere.
Many important articles are missing from PaperBLAST, either because
the article's full text is not in EuropePMC (as for many older
articles), or because the paper does not mention a protein identifier such as a locus tag, or because of PaperBLAST's heuristics. If you notice an
article that characterizes a protein's function but is missing from
PaperBLAST, please notify the curators at UniProt
or add an entry to GeneRIF.
Entries in either of these databases will eventually be incorporated
into PaperBLAST. Note that to add an entry to UniProt, you will need
to find the UniProt identifier for the protein. If the protein is not
already in UniProt, you can ask them to create an entry. To add an
entry to GeneRIF, you will need an NCBI Gene identifier, but
unfortunately many prokaryotic proteins in RefSeq do not have
corresponding Gene identifers.
References
PaperBLAST: Text-mining papers for information about homologs.
M. N. Price and A. P. Arkin (2017). mSystems, 10.1128/mSystems.00039-17.
Europe PMC in 2017.
M. Levchenko et al (2017). Nucleic Acids Research, 10.1093/nar/gkx1005.
Gene indexing: characterization and analysis of NLM's GeneRIFs.
J. A. Mitchell et al (2003). AMIA Annu Symp Proc 2003:460-464.
UniProt: the universal protein knowledgebase.
The UniProt Consortium (2016). Nucleic Acids Research, 10.1093/nar/gkw1099.
BRENDA in 2017: new perspectives and new tools in BRENDA.
S. Placzek et al (2017). Nucleic Acids Research, 10.1093/nar/gkw952.
The EcoCyc database: reflecting new knowledge about Escherichia coli K-12.
I. M. Keeseler et al (2016). Nucleic Acids Research, 10.1093/nar/gkw1003.
The MetaCyc database of metabolic pathways and enzymes.
R. Caspi et al (2018). Nucleic Acids Research, 10.1093/nar/gkx935.
CharProtDB: a database of experimentally characterized protein annotations.
R. Madupu et al (2012). Nucleic Acids Research, 10.1093/nar/gkr1133.
The carbohydrate-active enzymes database (CAZy) in 2013.
V. Lombard et al (2014). Nucleic Acids Research, 10.1093/nar/gkt1178.
The Transporter Classification Database (TCDB): recent advances
M. H. Saier, Jr. et al (2016). Nucleic Acids Research, 10.1093/nar/gkv1103.
REBASE - a database for DNA restriction and modification: enzymes, genes and genomes.
R. J. Roberts et al (2015). Nucleic Acids Research, 10.1093/nar/gku1046.
Deep annotation of protein function across diverse bacteria from mutant phenotypes.
M. N. Price et al (2016). bioRxiv, 10.1101/072470.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory