PaperBLAST
PaperBLAST Hits for CharProtDB::CH_091085 high-affinity fructose transporter ght6 (Schizosaccharomyces pombe) (535 a.a., MAKILTIVML...)
Show query sequence
>CharProtDB::CH_091085 high-affinity fructose transporter ght6 (Schizosaccharomyces pombe)
MAKILTIVMLVFVSMAGWMFGADTGSIGGITNMRDFQSRYADRYDPVTDTYSYSSARQGL
LVGMVNTGTTVGCLLSSPLGDRFGKRKCIMGWTLVYITGVIVQLTTIPSWVQMMVAKIWT
GLGIGALSVIAPGYQSESSPPHIRGAIVTTYQLFITLGIFIAACINMGTHKYTTHPEAQW
RVPIGINLLWGILMFFGMLFLPESPRYLAVKGRNEECMKILTRNAGLPADHPIMQKEYNA
IQADVEAELAGGPCSWPQIFSNEIRYRTLLGMGVMAFQQLTGNNYFFYYGTQVFRGTGLN
SPFLAALILDAVNFGCTFGAIFVLEYFGRRGPLIVGGVWQSICFFIYASVGDRALTRPNG
TSNHRAGAVMIVFSCLFIFSFAQTWAPAAYVIVGESYPIRYRSKCAAVATASNWFWNFMI
SFFTPFISNSIGFKYGYVFAACNLCAAIIIFLFAKETKGLTLEEINQLYLSNIKPWNTGA
YQRDREDIKQSDSEKERGPTSKLHEYVEHAPNSYASTHSTESENYPQQVTNPVGL
Running BLASTp...
Found 250 similar proteins in the literature:
TC 2.A.1.1.22 / O74849 Hexose:H+ symporter, Ght6 (Fructose > Glucose) from Schizosaccharomyces pombe (Fission yeast) (see 3 papers)
ght6 / RF|NP_587739.1 high-affinity fructose transporter ght6 from Schizosaccharomyces pombe (see paper)
SPCC1235.13 hexose transporter Ght6 (PMID 10735857) from Schizosaccharomyces pombe
100% identity, 100% coverage
- substrates: H+, Hexose
- Dataset describing the genome wide effects on transcription resulting from alterations in the relative levels of the bZIP transcription factors Atf1 and Pcr1 in Schizosaccharomyces pombe
Basu, Data in brief 2022 - “...SPAPB1E7.05 gde1 glycerophosphoryl diester phosphodiesterase Gde SPBC11C11.05 SPBC11C11.05 conserved fungal cell wall protein, Kre9/Knh1 family SPCC1235.13 ght6 plasma membrane glucose/fructose:proton symporter Ght6 SPBC14C8.01c cut2 sister chromatid separation inhibitor, securin SPAC821.09 eng1 cell septum surface endo-1,3-beta-glucanase Eng1 SPAC1006.08 etd1 Spg1-binding protein Etd1 SPBP26C9.03c fet4 plasma membrane iron/zinc...”
- The contribution of non-essential Schizosaccharomyces pombe genes to fitness in response to altered nutrient supply and target of rapamycin activity
Lie, Open biology 2018 - “...histone acetyltransferase catalytic subunit Gcn5 sensitive (T) SPAC1F8.01 ght3 hexose transmembrane transporter Ght3 sensitive (T) SPCC1235.13 ght6 hexose transmembrane transporter Ght6 sensitive (A, T) SPAC12G12.12 gms2 UDP-galactose transmembrane transporter Gms2 (predicted) sensitive (T) SPAC30D11.06c hfl1 Lazarus1 family transmembrane transporter resistant (G, P) SPBC2G2.01c liz1 pantothenate transmembrane...”
- Endocytosis is essential for dynamic translocation of a syntaxin 1 orthologue during fission yeast meiosis
Kashiwazaki, Molecular biology of the cell 2011 - “...Sec14 cytosolic family 0 PM, FSM ZK374 SPCC584.05 sec1 + SNARE-binding protein 0 FSM ZK375 SPCC1235.13 ght6 + /meu12 + Hexose transporter 10 PM, vacuole ZK230 SPCC1739.10 mug33 + Conserved fungal protein 4 Vacuole ZK228 Although internalization of both Psy1 and Pmd1 was facilitated during meiosis,...”
- Comprehensive isolation of meiosis-specific genes identifies novel proteins and unusual non-coding transcripts in Schizosaccharomyces pombe
Watanabe, Nucleic acids research 2001 - “...(3). ght6+ codes for a putative hexose transporter (SPCC1235.13) with close similarity to the Ght5 protein. Bgs2, a putative 1,3--glucan synthase component, was...”
SJAG_03606 hexose transporter Ght6 from Schizosaccharomyces japonicus yFS275
81% identity, 100% coverage
TC 2.A.1.1.112 / Q9P3U6 High-affinity glucose transporter Ght1 (Hexose transporter 1) from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (see 2 papers)
SPCC548.07c hexose transporter Ght1 (PMID 10735857) from Schizosaccharomyces pombe
70% identity, 96% coverage
- substrates: glucose
- Comparative genomics of the white-rot fungi, Phanerochaete carnosa and P. chrysosporium, to elucidate the genetic basis of the distinct wood types they colonize
Suzuki, BMC genomics 2012 - “...NcRco3 (CAE76420), Pp_115604 (EED81359), Ps_ABN65648.2 (ABN65648.2), PsSut1 (AAD00266), ScHxt1 (M82963), ScHxt7 (NP_010629), ScSnf3 (P10870), SpGht1 (Q9P3U6), Tm-CAZ81962.1 (CAZ81962.1), TrHxt1 (AAR23147), TrXlt1 (shown enlarged; AY818402), TrHxt2 (DQ852622; Ruohonen and Margolles-Clark, unpublished). The sequences were aligned using MAFFT, and the tree was drawn by FigTree. In the heatmap...”
- The Loz1 transcription factor from Schizosaccharomyces pombe binds to Loz1 response elements and represses gene expression when zinc is in excess
Wilson, Molecular microbiology 2019 - “...( Corkins et al. , 2013 , Ehrensberger et al. , 2014 ) TGACGATCGAA 1515 SPCC548.07c $ ght1 Plasma membrane highaffinity glucose:proton symporter 4.70 GGAAAATCCAA 1766 TGGCAATCCCC 1808 TGCAAATCGCC 1817 SPCC1529.01 $ Transmembrane transporter 3.48 GGAAAATCCAA 1281 TGGCAATCCCC 1239 TGCAAATCGCC 1230 SPCC569.05c Spermidine family transporter 2.84...”
NP_587740 plasma membrane high-affinity glucose/fructose:proton symporter Ght5 from Schizosaccharomyces pombe
SPCC1235.14 hexose transporter Ght5 (PMID 10735857) from Schizosaccharomyces pombe
69% identity, 97% coverage
GHT8_SCHPO / Q9P3U7 Probable high-affinity hexose transporter ght8, mitochondrial; Hexose transporter 8 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
SPCC548.06c hexose transporter Ght8 (predicted) from Schizosaccharomyces pombe
69% identity, 96% coverage
- Posttranslational Arginylation Enzyme Arginyltransferase1 Shows Genetic Interactions With Specific Cellular Pathways in vivo
Wiley, Frontiers in physiology 2020 - “...transcription factor activator Rep2 rpl3602 SPBC405.07 0.00082778 3.34334 60S ribosomal protein L36 RPL36A,RPL36B RPL36 ght8 SPCC548.06c 0.00086908 3.3298 Plasma membrane hexose:proton symporter, unknown specificity Ght8 (predicted) HXT15,HXT7,HXT6,STL1, HXT13, MAL11,HXT4, HXT1,HXT5,HXT8,HXT9, HXT16, GAL2,HXT2,HXT14, HXT17,HXT11 rpl35b SPBC1921.01c 0.00110496 3.26234 60S ribosomal protein L35a (predicted) RPL33B,RPL33A RPL35A rpl901 SPAC4G9.16c...”
- Proteasome regulation of petite-negativity in fission yeast.
Amberg, bioRxiv : the preprint server for biology 2024 - “...SPAC6G10.03c 0.43 0.030 mitochondrial cardiolipin-specific phospholipase Cld1 Q9HDU3 gal10 0.44 0.047 UDP-glucose 4-epimerase/aldose 1-epimerase Gal10 Q9P3U7 ght8 0.44 0.033 plasma membrane hexose:proton symporter, unknown specificity Ght8 Q9UQX0 sod2 0.46 0.009 mitochondrial superoxide dismutase Sod2 Q7Z9I3 SPCC663.08c 0.47 0.043 short chain dehydrogenase, unknown specificity O14295 plr1 0.47...”
SJAG_03608 hexose transporter Ght5 from Schizosaccharomyces japonicus yFS275
70% identity, 95% coverage
TC 2.A.1.1.21 / O74969 Hexose:H+ symporter, Ght2 (Glucose > Fructose) from Schizosaccharomyces pombe (Fission yeast) (see 3 papers)
ght2 / RF|NP_596425.1 high-affinity glucose transporter ght2 from Schizosaccharomyces pombe (see paper)
NP_596425 plasma membrane glucose/fructose:proton symporter Ght2 from Schizosaccharomyces pombe
68% identity, 98% coverage
SPBC1348.14c hexose transporter Ght7 from Schizosaccharomyces pombe
67% identity, 93% coverage
- Dataset describing the genome wide effects on transcription resulting from alterations in the relative levels of the bZIP transcription factors Atf1 and Pcr1 in Schizosaccharomyces pombe
Basu, Data in brief 2022 - “...wall glucan 1,6-beta-glucosidase Exg1 SPAPB1E7.04c SPAPB1E7.04c chitinase SPSNORNA.32 sno12 box H/ACA small nucleolar RNA 12/snR99 SPBC1348.14c ght7 plasma membrane hexose transmembrane transporter Ght7 SPNCRNA.942 SPNCRNA.942 intergenic RNA (predicted) SPRRNA.02 rns small subunit (15S) rRNA, rns SPAC186.09 pdc102 pyruvate decarboxylase SPBPB2B2.08 SPBPB2B2.08 conserved fungal protein SPNCRNA.532 SPNCRNA.532...”
- “...tlh1 RecQ type DNA helicase SPAC19G12.16c adg2 conserved fungal cell surface protein, Kre9/Knh1 family, Adg2 SPBC1348.14c ght7 plasma membrane hexose transmembrane transporter Ght7 SPAPB1E7.04c SPAPB1E7.04c chitinase SPBC1105.05 exg1 cell wall glucan 1,6-beta-glucosidase Exg1 SPRRNA.02 15S_rRNA small subunit (15S) rRNA, rns SPAC1039.11c gto1 alpha-glucosidase SPSNORNA.32 sno12 box...”
- High-throughput transcriptome sequencing and comparative analysis of Escherichia coli and Schizosaccharomyces pombe in respiratory and fermentative growth
Vichi, PloS one 2021 - “...not yet been assigned a function, such as SPBC32H8.15 and SPCC794.16, but others, such as SPBC1348.14c, encodes a high-affinity Ght7 permease involved in the introduction of hexose into cells, and SPAC1F8.02c which is involved in the transport of transmembrane iron during the cellular response to iron...”
- Expression profiling of S. pombe acetyltransferase mutants identifies redundant pathways of gene regulation
Nugent, BMC genomics 2010 - “...Log2 change p-value SPBC1348.09 1.89 3.69E-11 SPAC977.17 2.40 1.80E-08 map2 3.52 2.50E-12 SPAC22F8.05 1.90 0.001560473 SPBC1348.14c 2.41 2.14E-15 SPAPJ695.01c 3.52 2.00E-09 SPAC3C7.13c 1.92 3.23E-10 SPAC5H10.02c 2.46 3.89E-11 SPBC1198.01 3.55 7.19E-16 SPBPB2B2.06c 1.93 0.000987078 SPCC663.08c 2.54 0.009807792 SPAC22A12.17c 3.57 1.96E-11 SPBPB2B2.07c 1.93 9.41E-10 SPBC725.10 2.57 9.52E-05 SPAPB1A11.03...”
SJAG_02958 hexose transporter Ght5 from Schizosaccharomyces japonicus yFS275
67% identity, 85% coverage
ght4 / RF|NP_595064.1 hexose transporter Ght4 from Schizosaccharomyces pombe (see paper)
SPBC1683.08 hexose transporter Ght4 (PMID 10735857) from Schizosaccharomyces pombe
60% identity, 87% coverage
TC 2.A.1.1.23 / Q92339 Gluconate:H+ symporter, Ght3 from Schizosaccharomyces pombe (Fission yeast) (see 2 papers)
ght3 / RF|NP_592790.1 high-affinity gluconate transporter ght3 from Schizosaccharomyces pombe (see paper)
SPAC1F8.01 hexose transporter Ght3 (PMID 10735857) from Schizosaccharomyces pombe
58% identity, 88% coverage
- substrates: Gluconate
- Dataset describing the genome wide effects on transcription resulting from alterations in the relative levels of the bZIP transcription factors Atf1 and Pcr1 in Schizosaccharomyces pombe
Basu, Data in brief 2022 - “...esterase/lipase SPBPB2B2.06c SPBPB2B2.06c extracellular 5-nucleotidase, human NT5E family SPAC15E1.02c SPAC15E1.02c DUF1761 family protein, conserved unknown SPAC1F8.01 ght3 plasma membrane gluconate:proton symporter Ght3 SPAC19G12.09 SPAC19G12.09 NADH/NADPH-dependent indole-3-acetaldehyde reductase, implicated in cellular detoxification SPAC4F10.20 grx1 glutaredoxin Grx1 SPBC56F2.15 tam13 Schizosaccharomyces specific protein, uncharacterized SPBC16E9.16c lsd90 Lsd90 protein SPBC21C3.19...”
- “...meiosis-specific Smp foci lncRNA Sme2, long isoform SPAC4F10.20 grx1 glutaredoxin Grx1 SPAC22H10.13 zym1 metallothionein Zym1 SPAC1F8.01 ght3 plasma membrane gluconate:proton symporter Ght3 SPAC21E11.03c pcr1 DNA-binding transcription factor Pcr1 SPBC56F2.15 tam13 Schizosaccharomyces specific protein Tam13 SPCC1393.12 SPCC1393.12 Schizosaccharomyces specific protein, uncharacterized SPBC11C11.06c SPBC11C11.06c Schizosaccharomyces specific protein, uncharacterized...”
- The contribution of non-essential Schizosaccharomyces pombe genes to fitness in response to altered nutrient supply and target of rapamycin activity
Lie, Open biology 2018 - “...sensitive (G, P, A) SPAC1952.05 gcn5 SAGA complex histone acetyltransferase catalytic subunit Gcn5 sensitive (T) SPAC1F8.01 ght3 hexose transmembrane transporter Ght3 sensitive (T) SPCC1235.13 ght6 hexose transmembrane transporter Ght6 sensitive (A, T) SPAC12G12.12 gms2 UDP-galactose transmembrane transporter Gms2 (predicted) sensitive (T) SPAC30D11.06c hfl1 Lazarus1 family transmembrane...”
- A meiotic gene regulatory cascade driven by alternative fates for newly synthesized transcripts
Cremona, Molecular biology of the cell 2011 - “...12 2 rec8 SPBC29A10.14 4 Meiotic cohesin complex subunit 34.6 E 1 3 3 ght3 SPAC1F8.01 0 Hexose transporter 34.7 E 2 4 4 fbp1 SPBC1198.14c 0 Fructose-1,6-bisphosphatase 79.8 E 3 5 5 mei4 SPBC32H8.11 0 Meiotic forkhead transcription factor 54.9 M 4 5 6 SPAC1610.02c...”
- “...N 168.90 0.63 268.31 242 N meu25 SPBC27.03 N 174.05 0.61 287.69 263 N ght3 SPAC1F8.01 N 119.55 0.35 341.57 312 N fbp1 SPBC1198.14c N 344.85 0.81 425.22 390 N mug125 SPAC1A6.08c N 239.25 0.65 451.15 418 N mug132 SPAC11G7.06c N 224.80 0.48 465.91 434 N...”
- Loss of the TOR kinase Tor2 mimics nitrogen starvation and activates the sexual development pathway in fission yeast
Matsuo, Molecular and cellular biology 2007 - “...SPCC777.04 SPBC25B2.02c SPAC1399.01c SPAC29B12.14c SPBPB2B2.01 SPBC359.01 SPAC1F8.01 SPCC965.06 Gene name 3160 MATSUO ET AL. MOL. CELL. BIOL. strictive...”
CIMG_08310 sugar porter (SP) family MFS transporter from Coccidioides immitis RS
44% identity, 93% coverage
AO090020000259 No description from Aspergillus oryzae RIB40
45% identity, 79% coverage
AFUA_2G11520 MFS monosaccharide transporter, putative from Aspergillus fumigatus Af293
44% identity, 90% coverage
- Conservation of nucleosome positions in duplicated and orthologous gene pairs
Nishida, TheScientificWorldJournal 2012 - “...AFUA_3G04200 0.653965099 YMR110C AFUA_4G13500 0.649573592 YDR479C AFUA_2G01510 0.649340576 YLR307W AFUA_4G09940 0.641152119 YLL050C AFUA_5G10570 0.636927762 YMR011W AFUA_2G11520 0.631877767 YGR149W AFUA_3G08240 0.627253467 YKL125W AFUA_1G02590 0.626251676 YDL247W AFUA_3G01700 0.621782331 YHR165C AFUA_2G03030 0.616638486 YLR355C AFUA_3G14490 0.615946987 YLR307W AFUA_3G07210 0.615345397 YNL156C AFUA_4G07680 0.605449075 YOL157C AFUA_8G07070 0.600254438 YPL196W AFUA_3G08740 0.596649007 YOL156W AFUA_2G11520...”
- “...AFUA_3G07380 0.064624439 YIR038C AFUA_2G17300 0.068756542 YDL102W AFUA_2G16600 0.088010728 YOR389W AFUA_2G01940 0.09375584 YBR244W AFUA_3G12270 0.097477745 YJL219W AFUA_2G11520 0.098366126 YPL126W AFUA_7G02610 0.101632712 YDL189W AFUA_1G09400 0.104331651 YHL016C AFUA_1G04870 0.106608293 YLR380W AFUA_4G13930 0.111437921 YPR165W AFUA_6G06900 0.117573203 YOL062C AFUA_5G07930 0.122120003 YGL248W AFUA_1G14890 0.124318908 YLR029C AFUA_1G04660 0.129375946 YMR214W AFUA_2G08300 0.130867913 YOR124C AFUA_6G12270...”
- The proteomic signature of Aspergillus fumigatus during early development
Cagas, Molecular & cellular proteomics : MCP 2011 - “...AFUA_5G10070 AFUA_4G09600 AFUA_7G01010 AFUA_2G03830 AFUA_2G09030 AFUA_2G11520 AFUA_4G01290 ORF Name fatty acid beta-oxidation N-acetylglucosamine catabolic...”
AFUA_5G01160, Afu5g01160 MFS monosaccharide transporter, putative from Aspergillus fumigatus Af293
42% identity, 91% coverage
- Analysis of an Intrinsic Mycovirus Associated With Reduced Virulence of the Human Pathogenic Fungus Aspergillus fumigatus
Takahashi-Nakaguchi, Frontiers in microbiology 2019 - “...membrane transport was identified (RTA1 domain protein; AFUA_5G05640, MFS multidrug transporter; AFUA_4G01140, MFS monosaccharide transporter; AFUA_5G01160) ( Supplementary Table S2A ). Among the genes that were down-regulated in virus-infected A. fumigatus , the most drastic change was observed in the transcript encoding NAD-dependent formate dehydrogenase AciA/Fdh...”
- Comparative transcriptome analysis revealing dormant conidia and germination associated genes in Aspergillus species: an essential role for AtfA in conidial dormancy
Hagiwara, BMC genomics 2016 - “...- Conserved hypothetical protein Afu3g01210 An01g10950 AO090026000081 454.0 867.9 583.9 n.d. - ThiJ/PfpI family protein Afu5g01160 An03g02190 AO090020000259 338.5 21.7 12.7 full - Monosaccharide transporter Afu8g06020 An15g04770 AO090005000539 275.9 74.8 297.8 full - Glutamate decarboxylase Afu6g03890 An09g03130 AO090701000158 249.3 350.6 194.9 full catA Catalase A Afu1g03580...”
- Conservation of nucleosome positions in duplicated and orthologous gene pairs
Nishida, TheScientificWorldJournal 2012 - “...AFUA_8G05620 0.398124519 YHL001W AFUA_6G03830 0.397471165 YNL255C AFUA_1G07630 0.390527675 YGL006W AFUA_3G10690 0.389206341 YIL125W AFUA_4G11650 0.387564721 YMR011W AFUA_5G01160 0.381368332 YMR010W AFUA_5G03510 0.378223656 YMR319C AFUA_4G14640 0.376638524 YDL110C AFUA_1G09160 0.376540694 YOL086C AFUA_5G06240 0.376281416 YGR076C AFUA_4G09000 0.373900773 YOR204W AFUA_4G07660 0.368301524 YMR229C AFUA_2G16040 0.367246087 YLR025W AFUA_1G06420 0.363738278 YPL281C AFUA_6G06770 0.363265962 YOR294W AFUA_7G04430...”
- “...AFUA_7G01030 0.222088168 YBR179C AFUA_5G13392 0.219453048 YKR082W AFUA_4G05840 0.214144582 YLR087C AFUA_2G13520 0.209434557 YCL064C AFUA_4G07810 0.204494803 YOL156W AFUA_5G01160 0.203744073 YBR249C AFUA_7G04070 0.202306902 YJL093C AFUA_3G07540 0.201465401 YOL077C AFUA_1G02210 0.196710807 YLR426W AFUA_1G06280 0.196041865 YMR060C AFUA_2G03840 0.194299595 YOR048C AFUA_1G13730 0.193994391 YDL174C AFUA_7G02560 0.193117882 YJL221C AFUA_8G07070 0.187015236 YGR054W AFUA_3G05970 0.181434929 YPR176C AFUA_7G04460...”
- Evolutionary Analysis of Sequence Divergence and Diversity of Duplicate Genes in Aspergillus fumigatus
Yang, Evolutionary bioinformatics online 2012 - “...1.19 [0.21, 1.58] Afu2g08040 1.79 [1.81, 0.81] Afu5g01040 1.18 [1.12, 2.70] Afu6g09970 0.61 [1.25, 2.20] Afu5g01160 1.17 [0.65, 2.17] Afu8g01180 0.57 [1.44, 1.32] Afu8g04470 1.16 [0.66, 2.13] Afu6g11320 1.79 [2.31, 1.80] Afu7g00390 1.13 [0.49, 1.91] Afu3g01120 0.66 [0.98, 1.94] Afu5g00980 1.13 [0.82, 2.31] Afu1g10370 0.97 [1.82,...”
- The proteomic signature of Aspergillus fumigatus during early development
Cagas, Molecular & cellular proteomics : MCP 2011 - “...File 8 Hours Microarray Data AFUA_8G04550 AFUA_5G01160 AFUA_6G12000 AFUA_7G01010 AFUA_8G02440 AFUA_5G08830 16 Hours Microarray Data AFUA_4G13510 AFUA_1G01490...”
- Sub-telomere directed gene expression during initiation of invasive aspergillosis
McDonagh, PLoS pathogens 2008 - “...monocarboxylate transporter 4.628176816 Afu8g01130 alpha-galactosidase C 2.8084929 Afu6g03060 monosaccharide transporter 4.576610248 Afu4g01070 acid phosphatase 3.4709519 Afu5g01160 monosaccharide transporter 4.53846138 Afu7g05610 glucanase 3.7652613 Afu4g13080 monosaccharide transporter 4.316438927 Afu4g00870 antigenic cell wall galactomannoprotein 2.8100298 Afu7g05830 MFS sugar transporter 4.069715654 Afu6g02980 extracellular exo-polygalacturonase 6.9692415 Afu6g14500 MFS sugar transporter 3.883566446...”
ATEG_03527 uncharacterized protein from Aspergillus terreus NIH2624
43% identity, 88% coverage
- Transcriptome Profiling-Based Analysis of Carbohydrate-Active Enzymes in Aspergillus terreus Involved in Plant Biomass Degradation
Corrêa, Frontiers in bioengineering and biotechnology 2020 - “...during the 48 h incubation period, namely ATEG_07791, ATEG_03475, ATEG_07105, ATEG_04988, ATEG_01556, ATEG_07124, ATEG_08653, ATEG_07144, ATEG_03527, ATEG_02489, ATEG_07114, ATEG_04070, ATEG_07053, ATEG_04137, ATEG_03190, and ATEG_05008. RT-qPCR Validation of in silico RNA-Seq Transcriptome Data Expression profiles for selected A. terreus CAZyme-encoding and other genes significantly up-regulated on SB...”
An03g02190 uncharacterized protein from Aspergillus niger
42% identity, 85% coverage
- Comparative transcriptome analysis revealing dormant conidia and germination associated genes in Aspergillus species: an essential role for AtfA in conidial dormancy
Hagiwara, BMC genomics 2016 - “...Conserved hypothetical protein Afu3g01210 An01g10950 AO090026000081 454.0 867.9 583.9 n.d. - ThiJ/PfpI family protein Afu5g01160 An03g02190 AO090020000259 338.5 21.7 12.7 full - Monosaccharide transporter Afu8g06020 An15g04770 AO090005000539 275.9 74.8 297.8 full - Glutamate decarboxylase Afu6g03890 An09g03130 AO090701000158 249.3 350.6 194.9 full catA Catalase A Afu1g03580 An18g04120...”
- Aspergillus niger membrane-associated proteome analysis for the identification of glucose transporters
Sloothaak, Biotechnology for biofuels 2015 - “...HMM gluT was not observed in the three studied conditions. It is denoted as MstE (An03g02190) in the UniProt database, and has been found to be expressed in germinating spores [ 45 ]. The fifth highest scoring hit, with protein ID 1143191, is MstA. The mstA...”
- The effect of natamycin on the transcriptome of conidia of Aspergillus niger
van, Studies in mycology 2013 - “...of the most extremely up-regulated genes are An06g02270 (similar to an arabinose transport protein, 168-fold); An03g02190 (similarity to the sugar transporter Sut 1, 136-fold) and An13g00840 (similarity to amino acid protein GAP1, 132-fold). Table 5. Transcript levels of genes involved in trafficking, fission and fusion of...”
TC 2.A.1.1.36 / Q400D8 The low affinity, glucose-inducible glucose transporter, MstE from Emericella nidulans (Aspergillus nidulans) (see paper)
mstE low affinity glucose transporter MstE from Emericella nidulans (see paper)
42% identity, 89% coverage
- substrates: glucose
- CharProtDB Description: Low affinity glucose transporter of the major facilitator superfamily (MFS); Source:AspGD
TC 2.A.1.1.111 / P23585 High-affinity glucose transporter HXT2 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 6 papers)
NP_013724 hexose transporter HXT2 from Saccharomyces cerevisiae S288C
NP_013724, YMR011W High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose from Saccharomyces cerevisiae
44% identity, 89% coverage
- substrates: glucose
tcdb comment: Asp340 and Asn331 in part determine the high glucose affinity (Kasahara et al. 2007; Kasahara and Kasahara 2010) - Advances in fungal sugar transporters: unlocking the potential of second-generation bioethanol production
Pereira, Applied microbiology and biotechnology 2025 - “...S. cerevisiae Reifenberger et al. ( 1995 ); Apel et al. ( 2016 ) HXT2 P23585 Glucose, xylose, fructose, and mannose S. cerevisiae Reifenberger et al. ( 1995 ); Apel et al. ( 2016 ) HXT3 P32466 Glucose, fructose, and mannose S. cerevisiae Reifenberger et al....”
- Adaptive mutations in sugar metabolism restore growth on glucose in a pyruvate decarboxylase negative yeast strain
Zhang, Microbial cell factories 2015 - “...protein sequence of each of the four S. cereviciae proteins Cit1 (UniProt# P00890), Hxt2 (UniProt# P23585), Rpd3 (UniProt# P32561) and Mth1 (UniProt# P35198) was separately used to query the NCBI database with the basic local alignment search tool (BLAST). To eliminate sequences with low identity to...”
- Rapid response of the yeast plasma membrane proteome to salt stress
Szopinska, Molecular & cellular proteomics : MCP 2011 - “...MT P23291 P38250 P39004 P39003 P38695 P32467 P32466 P23585 P32465 P06775 P53154 P10823 P08539 P38631 Q08193 Q03655 P22146 P38196 P40088 Q12333 P32791 P23900...”
- Optimizing pentose utilization in yeast: the need for novel tools and approaches
Young, Biotechnology for biofuels 2010 - “...H2219 +* Saccharomyces cerevisiae HXT1 P32465 pYX212 [ 66 ] H2219 + Saccharomyces cerevisiae HXT2 P23585 pYX212 [ 66 ] H2219 + Saccharomyces cerevisiae HXT4 P32467 pYX212 [ 66 ] H2219 + Saccharomyces cerevisiae HXT7 P39004 pYX212 [ 66 ] H2219 + Saccharomyces cerevisiae HXT1 P32465...”
- Major facilitator superfamily
Pao, Microbiology and molecular biology reviews : MMBR 1998 - “...602 818 569 S59368 P13181 L21753 P49374 P32465 P23585 P32466 P32467 P38695 P39003 P39004 P40886 P43581 P40885 P39924 P42833 P47185 Z71687 P30605 X98622 P30606...”
- Increased xylose affinity of Hxt2 through gene shuffling of hexose transporters in Saccharomyces cerevisiae.
Nijland, Journal of applied microbiology 2018 (PubMed)- GeneRIF: The increased D-xylose affinity could be related to the C terminus, more specifically to a cysteine to proline mutation at position 505 in Hxt2.
- Low RNA Polymerase III activity results in up regulation of HXT2 glucose transporter independently of glucose signaling and despite changing environment.
Adamczyk, PloS one 2017 - GeneRIF: findings suggest that the general activity of RNAP III can indirectly affect the RNAP II transcriptional machinery on the HXT2 promoter when cellular perception transduced via the major signaling pathways, broadly recognized as on/off switch essential to either positive or negative HXT gene regulation, remain entirely intact
- Snf1p-dependent Spt-Ada-Gcn5-acetyltransferase (SAGA) recruitment and chromatin remodeling activities on the HXT2 and HXT4 promoters.
van, The Journal of biological chemistry 2006 (PubMed)- GeneRIF: Snf1p-dependent Spt-Ada-Gcn5-acetyltransferase (SAGA) recruitment and chromatin remodeling activities on the HXT2 and HXT4 promoters.
- Eight amino acid residues in transmembrane segments of yeast glucose transporter Hxt2 are required for high affinity transport.
Kasahara, The Journal of biological chemistry 2006 (PubMed)- GeneRIF: In addition to leucine 201 (TM5), four residues of Hxt2 (leucine 59 and leucine 61 in TM1, asparagine 331 in TM7, and phenylalanine 366 in TM8) were found to be important for high affinity transport
- The de novo design and synthesis of yeast chromosome XIII facilitates investigations on aging
Zhou, Nature communications 2024 - “...long-lived strains. In addition, an auxotrophic marker URA3, was integrated between two loxPsym sites tagging YMR011W and YMR012W on synXIII (270,117~270,525bp) to ensure a powerful positive selection for SCRaMbLEants from the library. To validate our approach, we developed a SCRaMbLE-mediated screening workflow to pinpoint strains with...”
- “...and simultaneously a URA3 marker was integrated into the middle of two loxPsym sites between YMR011W and YMR012W on synXIII at position (270,117~270,525bp). The colony was cultured in the SCHis medium overnight and then diluted to an A 600 of 0.1 in the 5mL fresh SCHis...”
- Yeast Double Transporter Gene Deletion Library for Identification of Xenobiotic Carriers in Low or High Throughput
Almeida, mBio 2021 - “...YKR103W, YKR106W, YLL028W, YLL043W, YLL048C, YLL052C, YLL061W, YLR081W, YLR092W, YLR130C, YLR138W, YLR237W, YML047C, YML116W, YML123C, YMR011W, YMR177W, YMR243C, YMR279C, YMR319C, YNL065W, YNL142W, YNL268W, YNL270C, YNL275W, YNL291C, YNL318C, YNR002C, YNR055C, YNR056C, YNR072W, YOL020W, YOL103W, YOL122C, YOL158C, YOR011W, YOR071C, YOR153W, YOR192C, YOR202W, YOR273C, YOR306C, YOR328W, YOR348C, YPL036W, YPL058C,...”
- Improved Xylose Metabolism by a CYC8 Mutant of Saccharomyces cerevisiae
Nijland, Applied and environmental microbiology 2017 - “...strains carrying CYC8(Y353) and CYC8(Y353C)a CYC8(Y353) Probe YMR011W YDR343C YDR342C YHR092C YHR096C YHR094C YJL214W YDL245C YJR158W YEL069C YFL011W YJL219W...”
- Extensive Copy Number Variation in Fermentation-Related Genes Among Saccharomyces cerevisiae Wine Strains
Steenwyk, G3 (Bethesda, Md.) 2017 - “...all other 10 members ( GAL2 / YLR081W , HXT1 / YHR094C , HXT2 / YMR011W , HXT4 / YHR092C , HXT5 / YHR096C , HXT8 / YJL214W , HXT10 / YFL011W , HXT16 / YJR158W , RGT2 / YDL138W , and SNF3 / YDL194W )...”
- Acetylated Deoxynivalenol Generates Differences of Gene Expression that Discriminate Trichothecene Toxicity
Suzuki, Toxins 2016 - “...SNF3 plasma membrane Plasma membrane low glucose sensor YHR094C HXT1 plasma membrane Low-affinity glucose transporter YMR011W HXT2 plasma membrane High-affinity glucose transporter YHR092C HXT4 plasma membrane High-affinity glucose transporter The gene expression of RGT1 , RGT2 , and SNF3 , which encode a component of a...”
- Phylogenetic and Transcripts Profiling of Glucose Sensing Related Genes in Candida glabrata
Ng, Jundishapur journal of microbiology 2015 - “...YKL038W CAA81873 1170 128.2 MIG1 YGL035C CAA96736 504 55.6 HXT1 YHR094C DAA06789 570 63.3 HXT2 YMR011W DAA09909 541 59.8 HXT3 YDR345C DAA12185 567 62.6 HXT4 YHR092C DAA06788 576 63.9 HXT5 YHR096C DAA06790 592 66.3 HXT6 YDR343C DAA12184 570 62.7 HXT7 YDR342C DAA12183 570 62.7 HXT8 YJL214W...”
- Low toxicity of deoxynivalenol-3-glucoside in microbial cells
Suzuki, Toxins 2015 - “...cAMP signaling Glucose response YBL043W ECM13 3.39 Non-essential protein of unknown function UVA irradiation response YMR011W HXT2 5.66 High-affinity glucose transporter Induced by low levels of glucose Repressed by high levels of glucose 2.3. Real-Time Polymerase Chain Reaction Analysis DNA microarray produces false-positive data that correspond...”
- The Recent De Novo Origin of Protein C-Termini
Andreatta, Genome biology and evolution 2015 - “...par 353 3 6 Frameshift 2 None Strong Potassium ion transmembrane transporter activity; Pheromone-regulated protein YMR011W HXT2 S. par 542 6 15 Frameshift 2 Strong Strong High-affinity glucose transmembrane transporter activity YMR240C CUS1 S. par 437 28 41 Frameshift 2 Strong Strong Unknown function; required for...”
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FGSG_07582 hypothetical protein from Fusarium graminearum PH-1
43% identity, 82% coverage
- Transcriptome-Based Discovery of Fusarium graminearum Stress Responses to FgHV1 Infection
Wang, International journal of molecular sciences 2016 - “...four mycoviruses, FgV1, FgV2, FgV3 and FgV4 [ 16 ]. Among these genes, FGSG_00878 and FGSG_07582 were also differentially expressed in the presence of FgHV1, showing down-regulation. FGSG_00878 encodes a hypothetical protein of unknown function, while FGSG_07582 belongs to the MFS. The MFS transporters are single-polypeptide...”
- “...10 10 Domain: Transmembrane amino acid transporter protein FGSG_06127 0.146473 6.70 10 85 Formate dehydrogenase FGSG_07582 0.152292 0 MFS transporter FGSG_03984 0.152931 1.161 10 3 l -lactate dehydrogenase FGSG_01450 0.157498 6.18 10 57 Domain: Calcipressin FGSG_11272 0.178327 1.05 10 13 ABC transporter FGSG_07598 0.183762 2.45 10...”
- Comparison of Fusarium graminearum Transcriptomes on Living or Dead Wheat Differentiates Substrate-Responsive and Defense-Responsive Genes
Boedi, Frontiers in microbiology 2016 - “...FGSG_06462 Related to coenzyme a synthetase C37 NRPS FGSG_06539 Related to ACB 4-hydroxyacetophenone monooxygenase C39 FGSG_07582 Probable low-affinity hexose transporter HXT3 C40 FGSG_07587 Related to sugar transport protein STL1 C40 FGSG_13167 Uncharacterized protein C40 FGSG_08178 Related to decarboxylase DEC1 C48 FGSG_10989 Related to enoyl-coa hydratase/isomerase C64...”
- A comparison of transcriptional patterns and mycological phenotypes following infection of Fusarium graminearum by four mycoviruses
Lee, PloS one 2014 - “...0.0275 4.26937 0.00365 FGSG_06969 F-box protein Fbl2 4.39156 0.01665 3.49683 0.0023 3.14555 0.0029 2.89172 0.04295 FGSG_07582 similar to monosaccharide transporter 5.39624 0.00275 1.82755 0.04485 2.73038 0.00585 3.94659 0.00805 FGSG_07587 similar to hexose carrier protein 3.62644 0.0219 1.83566 0.03675 1.99288 0.023 3.12381 0.02275 FGSG_09059 hypothetical protein 4.2155...”
An02g03540 uncharacterized protein from Aspergillus niger
41% identity, 90% coverage
- The antifungal peptide AnAFP from Aspergillus niger promotes nutrient mobilization through autophagic recycling during asexual development
Starke, Frontiers in microbiology 2024 - “...An12g04180 Aspartate transporter agtA -1.99 1.1E-02 An15g07190 Zinc transporter, endoplasmic reticulum membrane zrfA -2.25 6.5E-04 An02g03540 Hig-affinity hexose/H+ symporter mstE -2.28 7.2E-05 An02g14410 Ammonium transporter meaA -2.9 4.1E-02 An08g05670 Nitrate transporter crnA -3.88 6.8E-03 An07g06240 MFS transporter, ferric triacetylfusarinine C transport mirD -5.28 1.8E-02 An08g03200 Ammonium...”
- ERV14 receptor impacts mycelial growth via its interactions with cell wall synthase and transporters in Aspergillus niger
Zheng, Frontiers in microbiology 2023 - “...of proteome and the Y2H screening. Family Protein accession Gene ID Description MFS family CAK47634 An02g03540 Fructose transmembrane transporter CAK97262 An15g03940 Monosaccharide transporter CAK37108 An01g07860 Sulfate transmembrane transporter ABC family CAK43073 An17g01770 ATPase-coupled transmembrane transporter F-ATPase family CAK37765 An02g08020 H + -transporting ATPase lipid-binding protein P-ATPase...”
- Evaluation of Aspergillus niger Six Constitutive Strong Promoters by Fluorescent-Auxotrophic Selection Coupled with Flow Cytometry: A Case for Citric Acid Production
Lu, Journal of fungi (Basel, Switzerland) 2022 - “...genes in starch hydrolysis, glucose uptake, and glycolysis, such as amyA (An12g06930), glaA (An03g06550), mstC (An02g03540), mstG (An05g01290), mstH (An15g03940), pfkB (An07g02100), and ppcA (An11g02550) ( Table 2 ). As to intracellular citrate transportation, mitochondrial citrate/malate carrier protein CtpA (An11g11230) was also synergistically upregulated ( Table...”
- “...2.79 6.12 2.19 An12g06930 amyA Amylase 2.03 3.76 1.85 An03g06550 glaA Glucoamylase 2.83 6.49 2.29 An02g03540 mstC Low affinity glucose transporter 1.25 1.58 1.26 An05g01290 mstG High affinity glucose transporter 1.25 1.39 1.11 An15g03940 mstH High affinity glucose transporter 2.73 5.75 2.11 An04g06910 amyR Transcription factor...”
- Novel Treatment Approach for Aspergilloses by Targeting Germination
Verburg, Journal of fungi (Basel, Switzerland) 2022 - “...triggering breaking of dormancy. Negatively regulated by AtfA. A. fumigatus [ 97 ] CreA (An02g03830), (An02g03540) Fermentation/ Glycolysis: creA is a catabolite repressor. [ 174 ] FleA Recognizes and binds receptors, plays a role in attachment/adhesion to epithelial cells, as well as recognition by hosts immune...”
- RCO-3 and COL-26 form an external-to-internal module that regulates the dual-affinity glucose transport system in Neurospora crassa
Li, Biotechnology for biofuels 2021 - “...the WT strain [ 87 ]. In A. niger , the A. nidulans MstE ortholog An02g03540 showed a high expression level on glucose and maltose, and its expression in a amyR mutant was significantly downregulated [ 90 ]. To test the hypothesis that the dual-affinity glucose...”
- In Silico Analysis of Putative Sugar Transporter Genes in Aspergillus niger Using Phylogeny and Comparative Transcriptomics
Peng, Frontiers in microbiology 2018 - “...on the tested carbon sources. For instance, the low-affinity D -glucose transporter encoding gene mstC (An02g03540) and high-affinity D -glucose transporter encoding gene mstG (An05g01290) were higher expressed on hexose substrates than other monosaccharides. The D -galacturonic acid transporter encoding genes gatA (An14g04280) ( Sloothaak et...”
- Metabolic activity in dormant conidia of Aspergillus niger and developmental changes during conidial outgrowth
Novodvorska, Fungal genetics and biology : FG & B 2016 - “...genes encoding putative glucose/hexose transporters ( Pel et al., 2007 ) transcription of 5 genes (An02g03540, An15g03940, An05g01290, An16g08940, An02g01270) was highly upregulated at T1. The most upregulated was the homolog of A. nidulans mstE , (An02g03540) encoding a low affinity glucose transporter. Transcription of mstA...”
- “...Verified/putative function An11g04810 3.1 94.8 Alternative oxidase, aox1 An01g09290 85.1 17.6 Neutral trehalase, treB a An02g03540 15.8 489.9 Low affinity glucose transporter, mstE An15g03940 4.0 336.7 Monosaccharide transporter An05g01290 2.8 324.2 Monosaccharide transporter An16g08940 5.1 118.8 Monosaccharide transporter An02g01270 1.6 25.8 Monosaccharide transporter An12g07450 1.6 9.5...”
- Trancriptional landscape of Aspergillus niger at breaking of conidial dormancy revealed by RNA-sequencing
Novodvorska, BMC genomics 2013 - “...phosphoglycerate kinase 19.01 32.17 15.68 2.05 An02g03830 creA , catabolite repressor 2.57 4.43 30.22 6.82 An02g03540 hexose transport protein 42.48 33.08 523.81 15.83 GABA shunt An10g00090 glutamate dehydrogenase 89.12 246.31 3.87 63.64 An15g04770 glutamate decarboxylase 63.83 62.34 2.3 27.10 An08g08840 glutamate decarboxylase 5.74 16.85 3.14 5.36...”
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KHT2 / CAA87389.1 permease from Kluyveromyces lactis (see paper)
P53387 Hexose transporter 2 from Kluyveromyces lactis
43% identity, 85% coverage
VDAG_05443 galactose transporter from Verticillium dahliae VdLs.17
43% identity, 93% coverage
PDIP_55020 MFS monosaccharide transporter, putative from Penicillium digitatum
43% identity, 91% coverage
- Transcriptome Analysis of mfs2-Defective Penicillium digitatum Mutant to Reveal Importance of Pdmfs2 in Developing Fungal Prochloraz Resistance
Cuan, Microorganisms 2024 - “...up-regulation of multiple MFS isogenes, including MFS23 (PDIP_36610), MFS26 (PDIP_64100), MFS27 (PDIP_55370), MFS31 (PDIP_19850), MFS33 (PDIP_55020) ( Table 8 ). All these five MFS-encoding genes did not show up-regulation in the comparison Pd-d-(I/NI); however, three of them (i.e., MFS23 , MFS26 and MFS27 ) showed up-regulation...”
- “...1.15 / MFS31 (PDIP_19850) / 2.63 / 2.05 MFS32 (PDIP_28570) 1.23 1.11 / / MFS33 (PDIP_55020) / 1.07 / 1.22 ABC1 (PDIP_64370) / / 1.35 1.71 ABC2 (PDIP_58890) / / 1.18 / ABC3 (PDIP_13640) 2.75 1.09 2.84 1.18 ABC4 (PDIP_19230) 1.05 / 2.20 1.43 ABC5 (PDIP_78490)...”
XP_025453682 general substrate transporter from Aspergillus niger CBS 101883
43% identity, 90% coverage
TC 2.A.1.1.58 / Q8J0U9 Low affinity glucose:H+ symporter, MstC from Aspergillus niger
43% identity, 82% coverage
CCM_01166 siderophore iron transporter mirC from Cordyceps militaris CM01
41% identity, 85% coverage
- Metabolic comparison of aerial and submerged mycelia formed in the liquid surface culture of Cordyceps militaris
Suparmin, MicrobiologyOpen 2019 - “...12days of culture. In addition, the expression of the siderophore iron transporters mirB (CCM_08808), mirC (CCM_01166), FtrA (CCM_05132), sit1 (CCM_08222), and Atx1, putative (CCM_02485) and the ironrelated transporters (CCM_02485, CCM_08222, CCM_05132, CCM_07591, and CCM_01166) involved in the metabolism of iron were differentially expressed at 12th day...”
AFUA_7G00950, Afu7g00950 MFS monosaccharide transporter, putative from Aspergillus fumigatus Af293
42% identity, 92% coverage
- Broad-spectrum antimicrobial activities of a food fermentate of <i>Aspergillus oryzae</i>
Choi, Microbiology spectrum 2024 - “...AFUA_1G04780 pxa1 Putative peroxisomal ABC transporter 2.38 AFUA_1G14330 abcC Putative ABC transporter, Azole transporter 2.35 AFUA_7G00950 Putative MFS monosaccharide transporter 2.25 AFUA_2G12500 Putative MFS multidrug transporter 2.25 AFUA_3G01840 Putative MFS transporter 2.25 AFUA_6G03060 Putative MFS monosaccharide transporter 2.14 AFUA_4G03750 Putative phthalate transporter 2.05 AFUA_6G03720 Putative MFS...”
- Induction of <i>Aspergillus fumigatus</i> zinc cluster transcription factor OdrA/Mdu2 provides combined cellular responses for oxidative stress protection and multiple antifungal drug resistance
Sasse, mBio 2023 - “...Up +753 (inside the 2nd intron) Afu4g14380 Up Up 247 Afu5g06070 mdr1 Up Up 1668 Afu7g00950 Up Up 1038 Afu8g01860 Up Up 181 Afu8g06430 Up Down Not found Afu2g02690 atrR/odrD Up 811 Afu3g01910 Down Up 152 Afu3g01910 Down Up +1447 (inside the seventh exon) Afu5g14740 fleA...”
- A Novel Zn2-Cys6 Transcription Factor AtrR Plays a Key Role in an Azole Resistance Mechanism of Aspergillus fumigatus by Co-regulating cyp51A and cdr1B Expressions
Hagiwara, PLoS pathogens 2017 - “...6.46 9.32 hypothetical protein Afu5g06070 mdr1 11.9 65.9 108.2 5.53 9.09 ABC multidrug transporter Mdr1 Afu7g00950 10.3 60.5 77.7 5.87 7.54 MFS monosaccharide transporter, putative Afu8g01860 30.6 163.0 218.8 5.32 7.15 hypothetical protein DOWN in atrR and srbA Afu1g03150 erg24A 25.5 1.1 2.5 0.04 0.10 c-14...”
- Temperature during conidiation affects stress tolerance, pigmentation, and trypacidin accumulation in the conidia of the airborne pathogen Aspergillus fumigatus
Hagiwara, PloS one 2017 - “...3.1 13.69 0.99 conserved hypothetical protein AFUA_8G04920 201.1 14.9 8.2 13.49 0.55 LEA domain protein AFUA_7G00950 285.3 22.1 26.7 12.89 1.21 MFS monosaccharide transporter, putative AFUA_5G00145 101.3 8.1 2.5 12.48 0.31 conserved hypothetical protein AFUA_4G00730 3748.9 308.7 61.8 12.14 0.20 HHE domain protein AFUA_3G14750 31.9 2.6...”
- Conservation of nucleosome positions in duplicated and orthologous gene pairs
Nishida, TheScientificWorldJournal 2012 - “...AFUA_5G13130 0.490832735 YDR055W AFUA_4G06820 0.482973721 YLR104W AFUA_5G04040 0.47610876 YIL129C AFUA_6G11010 0.473123981 YDR300C AFUA_2G07570 0.469287567 YOL156W AFUA_7G00950 0.46726022 YGL201C AFUA_5G10890 0.462753539 YKR086W AFUA_1G03820 0.461061937 YPL157W AFUA_6G08610 0.460257721 YIL046W AFUA_2G14110 0.45798838 YGL048C AFUA_4G04660 0.457664607 YHR216W AFUA_2G03610 0.456902272 YDR424C AFUA_1G04850 0.455530713 YPR141C AFUA_2G14280 0.452133975 YLR427W AFUA_1G07150 0.444534443 YHL004W AFUA_1G06570...”
- “...AFUA_2G02850 0.284622252 YLR429W AFUA_2G14270 0.283845667 YDR397C AFUA_3G02340 0.283499213 YBR260C AFUA_3G06280 0.282196097 YCR087C-A AFUA_7G04700 0.281322207 YMR011W AFUA_7G00950 0.280854319 YOL148C AFUA_1G16580 0.274850272 YDR379W AFUA_1G12680 0.273041289 YJL151C AFUA_5G10590 0.272979399 YML020W AFUA_5G12090 0.266526854 YGR082W AFUA_6G11380 0.265129767 YJR113C AFUA_1G04280 0.262789584 YIL031W AFUA_5G03200 0.256820972 YDR432W AFUA_3G10100 0.255963453 YDR359C AFUA_4G07560 0.255317292 YDR233C AFUA_6G13670...”
An05g01290 uncharacterized protein from Aspergillus niger
43% identity, 90% coverage
- Evaluation of Aspergillus niger Six Constitutive Strong Promoters by Fluorescent-Auxotrophic Selection Coupled with Flow Cytometry: A Case for Citric Acid Production
Lu, Journal of fungi (Basel, Switzerland) 2022 - “...starch hydrolysis, glucose uptake, and glycolysis, such as amyA (An12g06930), glaA (An03g06550), mstC (An02g03540), mstG (An05g01290), mstH (An15g03940), pfkB (An07g02100), and ppcA (An11g02550) ( Table 2 ). As to intracellular citrate transportation, mitochondrial citrate/malate carrier protein CtpA (An11g11230) was also synergistically upregulated ( Table 2 )....”
- “...An03g06550 glaA Glucoamylase 2.83 6.49 2.29 An02g03540 mstC Low affinity glucose transporter 1.25 1.58 1.26 An05g01290 mstG High affinity glucose transporter 1.25 1.39 1.11 An15g03940 mstH High affinity glucose transporter 2.73 5.75 2.11 An04g06910 amyR Transcription factor 2.35 2.59 1.10 An08g02260 pgkA Phosphoglycerate kinase 1.32 1.37...”
- In Silico Analysis of Putative Sugar Transporter Genes in Aspergillus niger Using Phylogeny and Comparative Transcriptomics
Peng, Frontiers in microbiology 2018 - “...D -glucose transporter encoding gene mstC (An02g03540) and high-affinity D -glucose transporter encoding gene mstG (An05g01290) were higher expressed on hexose substrates than other monosaccharides. The D -galacturonic acid transporter encoding genes gatA (An14g04280) ( Sloothaak et al., 2014 ) and the D -xylose transporter encoding...”
- Metabolic activity in dormant conidia of Aspergillus niger and developmental changes during conidial outgrowth
Novodvorska, Fungal genetics and biology : FG & B 2016 - “...putative glucose/hexose transporters ( Pel et al., 2007 ) transcription of 5 genes (An02g03540, An15g03940, An05g01290, An16g08940, An02g01270) was highly upregulated at T1. The most upregulated was the homolog of A. nidulans mstE , (An02g03540) encoding a low affinity glucose transporter. Transcription of mstA encoding a...”
- “...lower transcript levels in the sorbic acid condition than in the control sample, apart from An05g01290. Glucokinase (An12g08610) is a high affinity glucose phosphorylating enzyme necessary for the activation of intracellular glucose and it plays an important role in the germination process especially in low glucose...”
G0RKF0 Galactose permease from Hypocrea jecorina (strain QM6a)
43% identity, 83% coverage
- Advances in fungal sugar transporters: unlocking the potential of second-generation bioethanol production.
Pereira, Applied microbiology and biotechnology 2025 - “...xylose, fructose, galactose, mannose, and L-arabinose T. reesei Sloothaak et al. ( 2016b ) STR3 G0RKF0 Glucose, xylose, fructose, galactose, and mannose T. reesei Sloothaak et al. ( 2016b ) GLT1 G0RGR7 Glucose T. reesei Havukainen et al. ( 2021b ) STP1 G0RIJ1 Glucose, fructose, galactose,...”
XP_445530 hypothetical protein from Candida glabrata CBS 138
44% identity, 84% coverage
- Phylogenetic and Transcripts Profiling of Glucose Sensing Related Genes in Candida glabrata
Ng, Jundishapur journal of microbiology 2015 - “...XP_444861 549 61.2 HXT6/7 CAGL0A02211 XP_444860 552 61.5 HXT6/7 CAGL0A00737 XP_444803 549 61.6 HXT2/10 CAGL0D02662 XP_445530 564 62.4 HXT2/10 CAGL0D02640 XP_445530 564 62.4 HXT2/10 CAGL0I00286 XP_447265 555 61.7 HXT14 CAGL0M04103 XP_449525 531 59.0 Table 2. Details of Glucose Sensing-Related Genes of Saccharomyces cerevisiae Target Gene Name...”
TDEL0A04250 uncharacterized protein from Torulaspora delbrueckii
44% identity, 86% coverage
- Evolution and functional diversification of yeast sugar transporters
Donzella, Essays in biochemistry 2023 - “...S. cerevisiae ) is also interesting as it also has a T. delbrueckii orthologue ( TDEL0A04250 ). The branching position, supported by good bootstraps, indicates that the ancestor of this gene even precedes the duplication of the original HXT that gave rise the KHT1 -like and...”
TC 2.A.1.1.5 / P43581 Hexose uniporter from Saccharomyces cerevisiae (Baker's yeast) (see 2 papers)
HXT10 / RF|NP_116644.1 hexose transporter HXT10 from Saccharomyces cerevisiae
YFL011W Hxt10p from Saccharomyces cerevisiae
43% identity, 89% coverage
- substrates: Hexoses
- Yeast Double Transporter Gene Deletion Library for Identification of Xenobiotic Carriers in Low or High Throughput
Almeida, mBio 2021 - “...YDL199C, YDR011W, YDR046C, YDR345C, YDR384C, YDR387C, YDR406W, YDR497C, YDR508C, YDR536W, YEL063C, YEL065W, YER056C, YER145C, YER166W, YFL011W, YFL040W, YFL050C, YFL055W, YGL077C, YGL114W, YGL255W, YGR055W, YGR121C, YGR138C, YGR217W, YGR224W, YGR260W, YGR281W, YGR289C, YHL016C, YHL040C, YHL047C, YHR092C, YHR094C, YHR096C, YIL013C, YIL088C, YIL120W, YIL121W, YJL093C, YJL129C, YJL212C, YJL214W, YJR040W, YJR054W,...”
- Improved Xylose Metabolism by a CYC8 Mutant of Saccharomyces cerevisiae
Nijland, Applied and environmental microbiology 2017 - “...YDR343C YDR342C YHR092C YHR096C YHR094C YJL214W YDL245C YJR158W YEL069C YFL011W YJL219W YOL156W YLR081W YNL318C Sum of all HXTs Sum of all genes Gene HXT2 HXT36...”
- Extensive Copy Number Variation in Fermentation-Related Genes Among Saccharomyces cerevisiae Wine Strains
Steenwyk, G3 (Bethesda, Md.) 2017 - “..., HXT4 / YHR092C , HXT5 / YHR096C , HXT8 / YJL214W , HXT10 / YFL011W , HXT16 / YJR158W , RGT2 / YDL138W , and SNF3 / YDL194W ) of the HXT gene family ( Figure 3 ). Interestingly, all remaining 10 members of the...”
- Different Toxicity Mechanisms for Citrinin and Ochratoxin A Revealed by Transcriptomic Analysis in Yeast
Vanacloig-Pedros, Toxins 2016 - “...5.34 10 7 Meiosis-specific recombinase YOR298W MUM3 33.5 9.62 10 4 Protein of unknown function YFL011W HXT10 33.2 1.38 10 7 Putative hexose transporter YLL046C RNP1 27.3 1.08 10 7 Ribonucleoprotein YER104W RTT105 26.0 3.22 10 8 Protein with a role in regulation of Ty1 transposition...”
- Phylogenetic and Transcripts Profiling of Glucose Sensing Related Genes in Candida glabrata
Ng, Jundishapur journal of microbiology 2015 - “...YDR342C DAA12183 570 62.7 HXT8 YJL214W DAA08597 569 63.5 HXT9 YJL219W DAA08593 567 62.9 HXT10 YFL011W DAA12428 546 60.7 HXT11 YOL156W DAA10630 567 62.7 HXT13 YEL069C DAA07586 564 62.7 HXT14 YNL318C CAA96250 540 61.0 HXT15 YDL245C DAA11622 567 62.9 HXT16 YJR158W DAA08942 567 62.9 HXT17 YNR072W...”
- Mutation rates across budding yeast chromosome VI are correlated with replication timing
Lang, Genome biology and evolution 2011 - “...106463 GL44 YFR045W Hypothetical 242129 GL20 YFL012W Hypothetical 110641 GL45 b YFR049W YMR31 248510 GL21 YFL011W HXT10 112339 GL46 YFR053C HXK1 253579 GL22 YFL010C WWM1 115102 GL47 YFR054C Hypothetical 258842 GL23 YFL007W BLM3 123474 GL48 YFR055W Hypothetical 264191 GL24 YFL004W VTC2 131805 GL49 YFR057W Hypothetical 269048...”
- Transcriptomic profiling of the Saccharomyces cerevisiae response to quinine reveals a glucose limitation response attributable to drug-induced inhibition of glucose uptake
dos, Antimicrobial agents and chemotherapy 2009 - “...Membrane transport YCL025c YHR094c YMR011w YDR345c YHR092c YHR096c YJL214w YFL011w YKL217w YHL036w YML123c YCR037c YBR106w YBR296c YFL054c -- -- S R -- S -- S...”
- Positional analyses of BRCA1-dependent expression in Saccharomyces cerevisiae
Skibbens, Cell cycle (Georgetown, Tex.) 2008 - “...Up 2.9735975 Up YCL030C HIS4 2.7684693 Up 2.5967464 Up YIL116W HIS5 3.793316 Up 5.640973 Up YFL011W HXT10 2.7209184 Up 2.324241 Up YHR096C HXT5 3.2667696 Up 3.6192696 Up YJL219W HXT9 2.1079352 Up 2.2038836 Up YMR108W ILV2 3.0951784 Up 8.414132 Up YKL217W JEN1 2.4908004 Up 2.6344728 Up YGL009C...”
- More
- Optimizing pentose utilization in yeast: the need for novel tools and approaches
Young, Biotechnology for biofuels 2010 - “...TMB3201 - Saccharomyces cerevisiae HXT9 P40885 p4H7 [ 64 ] TMB3201 - Saccharomyces cerevisiae HXT10 P43581 p4H7 [ 64 ] TMB3201 - Saccharomyces cerevisiae HXT11 P54862 p426MET25 [ 64 ] TMB3201 - Saccharomyces cerevisiae HXT13 P39924 p4H7 [ 64 ] TMB3201 - Saccharomyces cerevisiae HXT14 P42833...”
- Major facilitator superfamily
Pao, Microbiology and molecular biology reviews : MMBR 1998 - “...P32465 P23585 P32466 P32467 P38695 P39003 P39004 P40886 P43581 P40885 P39924 P42833 P47185 Z71687 P30605 X98622 P30606 S51081 P07921 P38156 P15685 P18631 X96876...”
- “...Th2A of Trypanosoma brucei P37021 P09830 P09098 P21906 P43581 P13181 P11636 P30605 P07921 P15685 S59368 Q07647 U11843 P15686 Q02563 X78855 Q06222 SP SP SP...”
XP_002490706 High-affinity glucose transporter of the major facilitator superfamily from Komagataella phaffii GS115
43% identity, 90% coverage
KLMA_50360 hexose transporter 2 from Kluyveromyces marxianus DMKU3-1042
42% identity, 88% coverage
XP_007868407 uncharacterized protein from Gloeophyllum trabeum ATCC 11539
43% identity, 84% coverage
FVEG_12687 MFS transporter, SP family, sugar:H+ symporter from Fusarium verticillioides 7600
42% identity, 81% coverage
- Transcriptome changes in Fusarium verticillioides caused by mutation in the transporter-like gene FST1
Niu, BMC microbiology 2015 - “...identified eight genes with high sequence similarity (FVEG_01519, FVEG_01638, FVEG_02081, FVEG_03992, FVEG_06504, FVEG_07757, FVEG_11293, and FVEG_12687). The sequence of FST1 was not identified by the search. Among the eight identified genes, expression was significantly down-regulated in fst1 for FVEG_06504 (named ITR1 ) (19-fold) and FVEG_03992 (5-fold),...”
ATEG_08653 uncharacterized protein from Aspergillus terreus NIH2624
43% identity, 52% coverage
- Transcriptome Profiling-Based Analysis of Carbohydrate-Active Enzymes in Aspergillus terreus Involved in Plant Biomass Degradation
Corrêa, Frontiers in bioengineering and biotechnology 2020 - “...and SH during the 48 h incubation period, namely ATEG_07791, ATEG_03475, ATEG_07105, ATEG_04988, ATEG_01556, ATEG_07124, ATEG_08653, ATEG_07144, ATEG_03527, ATEG_02489, ATEG_07114, ATEG_04070, ATEG_07053, ATEG_04137, ATEG_03190, and ATEG_05008. RT-qPCR Validation of in silico RNA-Seq Transcriptome Data Expression profiles for selected A. terreus CAZyme-encoding and other genes significantly up-regulated...”
XP_719472 Hgt7p from Candida albicans SC5314
41% identity, 93% coverage
- Genetic basis of the highly efficient yeast Kluyveromyces marxianus: complete genome sequence and transcriptome analyses
Lertwattanasakul, Biotechnology for biofuels 2015 - “...Kl_HXT14, XP_454897; Kl_HXT2, XP_453960; Kl_HXT3, XP_453088; Sc_HXT4/LGT1, NP_011960; Kl_STL1, XP_456249; Kl_RAG4, XP_455315; Kl_LAC12, XP_452193; Ca_HXT6, XP_719472. Genes for the initial catabolism of xylose, PPP, the conversion of PEP to ethanol, the mitochondrial conversion of acetaldehyde to acetyl-CoA and TCA cycle were relatively upregulated (Figure 2 A,B)....”
TC 2.A.1.1.105 / P54862 Hexose transporter HXT11 (Low-affinity glucose transporter LGT3) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 3 papers)
YOL156W Hxt11p from Saccharomyces cerevisiae
41% identity, 87% coverage
- substrates: Hexoses
- Improved Xylose Metabolism by a CYC8 Mutant of Saccharomyces cerevisiae
Nijland, Applied and environmental microbiology 2017 - “...YHR092C YHR096C YHR094C YJL214W YDL245C YJR158W YEL069C YFL011W YJL219W YOL156W YLR081W YNL318C Sum of all HXTs Sum of all genes Gene HXT2 HXT36 HXT7 HXT4 HXT5...”
- Complete genome sequence and comparative genomics of the probiotic yeast Saccharomyces boulardii
Khatri, Scientific reports 2017 - “...of unknown function YGR295C COS6 Protein of unknown function YOL158C ENB1 Endosomal ferric enterobactin transporter YOL156W HXT11 Putative hexose transporter that is nearly identical to Hxt9p YJL219W HXT9 Putative hexose transporter that is nearly identical to Hxt11p YOL157C IMA2 Isomaltase YIL172C IMA3 Isomaltase YJL221C IMA4 Isomaltase...”
- Extensive Copy Number Variation in Fermentation-Related Genes Among Saccharomyces cerevisiae Wine Strains
Steenwyk, G3 (Bethesda, Md.) 2017 - “...( HXT6 / YDR343C , HXT7 / YDR342C , HXT9 / YJL219W , HXT11 / YOL156W , HXT13 / YEL069C , HXT15 / YDL245C , and HXT17 / YNR072W ), which is involved in sugar transport, that were among the 363 CN diverse genes (File S3...”
- Phylogenetic and Transcripts Profiling of Glucose Sensing Related Genes in Candida glabrata
Ng, Jundishapur journal of microbiology 2015 - “...YJL214W DAA08597 569 63.5 HXT9 YJL219W DAA08593 567 62.9 HXT10 YFL011W DAA12428 546 60.7 HXT11 YOL156W DAA10630 567 62.7 HXT13 YEL069C DAA07586 564 62.7 HXT14 YNL318C CAA96250 540 61.0 HXT15 YDL245C DAA11622 567 62.9 HXT16 YJR158W DAA08942 567 62.9 HXT17 YNR072W DAA10613 564 62.8 3.2. Phylogenetic...”
- Conservation of nucleosome positions in duplicated and orthologous gene pairs
Nishida, TheScientificWorldJournal 2012 - “...0.986389631 0.991000914 781603 chr15 YOL166W-A 0.969218719 0.964760148 585 + chr15 YOL157C 0.977029388 0.98945557 24293 chr15 YOL156W 0.979765672 0.992685071 25272 + chr15 YOL148C 0.957761501 0.971157209 47573 chr15 YOL104C 0.976917372 0.981386975 117454 chr15 YOL100W 0.961328138 0.959394148 129237 + chr15 YOL089C 0.971692903 0.984860678 153490 chr15 YOL086C 0.976082094 0.966862518 160594...”
- “...YLR355C AFUA_3G14490 0.615946987 YLR307W AFUA_3G07210 0.615345397 YNL156C AFUA_4G07680 0.605449075 YOL157C AFUA_8G07070 0.600254438 YPL196W AFUA_3G08740 0.596649007 YOL156W AFUA_2G11520 0.589475104 YGL055W AFUA_7G05920 0.583471232 YER094C AFUA_4G07420 0.580111415 YER026C AFUA_4G13680 0.579632053 YKR031C AFUA_3G05630 0.578947614 YJR041C AFUA_1G13200 0.577042969 YCL057C-A AFUA_1G13195 0.56703028 YKL167C AFUA_6G12620 0.566497151 YDR334W AFUA_7G02370 0.556810391 YDL085W AFUA_1G11960 0.555058025 YIR038C...”
- A rapid and inexpensive labeling method for microarray gene expression analysis
Ouellet, BMC biotechnology 2009 - “...3.2* 2.9** YGR236C ( SPG1 ) 0.4** 0.4* 0.7* 0.5** YLR346C 7.7** 6.9** 2.0** 6.2** YOL156W 12.9** 9.7** 4.2** 6.8** (* p -value < 0.05; ** p -value < 0.01) We also had access to data collected using a new gene expression technology, the NanoStrings nCounter...”
- “...FMP48 ATCTGATGTTCGGCGATTGCCTT TGCTGCAGGCTAACGTGTAGGTCTT YGR236C SPG1 ATATTATGTTAGGGCTGGTGGGCGC GCCTTAGTTGTGTCTACGCCGTTGA YJL219W HXT9 AAGTTGTGGCCTCAAGGAAGCAGTC TTGCCATTCCTCTTGATTTGACCCT YLR346C - TTGCAGAGTGGGTAGCATGTCCATG TCCTGGGCAGCCTTGAGTAAATCAT YOL156W HXT11 ATGCTGCTTTGCTGTGTTTGCCTC TAACGTAACAGCCGCCTGCCCA YNL072W RNH201 GGACCACCAGCGTCCTATCAGAAGA TCATCGGGATCCCTCTTCAAGGA YLR185W RPL37a CCTGTTCCTCCTGTGGTTATCCAGC AAGCAGAGCCGGTTTGGAAACC Authors' contributions MO conceptualized the method. MO and AM designed the experiments. MO conducted experiments and analyzed the data....”
- Systematic identification of balanced transposition polymorphisms in Saccharomyces cerevisiae
Faddah, PLoS genetics 2009 - “...initial genome assembly, S. paradoxus contig 539 contains homologs to the genes YOL157C (probe 25), YOL156W (probe 27) and YOL155C (probe 30), which span the proximal endpoint of the transposed segment and are arranged in the same order and orientation as in S288C ( Figure 8...”
- Analysis of mechanisms of T-2 toxin toxicity using yeast DNA microarrays
Iwahashi, International journal of molecular sciences 2008 - “...treatment in yeast. Systematic Normalized Common Description YJL089W 15.7 SIP4 interacts with SNF1 protein kinase YOL156W 15.7 HXT11 Hxt family protein with intrinsic hexose transport activity YJL219W 12.8 HXT9 Hxt family protein with intrinsic hexose transport activity YNL279W 12.4 PRM1 similarity to S. pombe coiled-coil protein...”
- More
- Novel Citronellyl-Based Photoprobes Designed to Identify ER Proteins Interacting with Dolichyl Phosphate in Yeast and Mammalian Cells.
Rush, Current chemical biology 2015 - “...P53134 12 Putative oligopeptide transporter YGL114W + + Q02785 11 ATP-dependent permease PDR12 + + P54862 11 Hexose transporter HXT11 + + P40885 11 Hexose transporter HXT9 + + P39003 11 High-affinity hexose transporter HXT6 + + P39004 11 High-affinity hexose transporter HXT6 + + P32466...”
- Optimizing pentose utilization in yeast: the need for novel tools and approaches
Young, Biotechnology for biofuels 2010 - “...TMB3201 - Saccharomyces cerevisiae HXT10 P43581 p4H7 [ 64 ] TMB3201 - Saccharomyces cerevisiae HXT11 P54862 p426MET25 [ 64 ] TMB3201 - Saccharomyces cerevisiae HXT13 P39924 p4H7 [ 64 ] TMB3201 - Saccharomyces cerevisiae HXT14 P42833 p4H7 [ 64 ] TMB3201 - Saccharomyces cerevisiae HXT15 P54854...”
HGT7 potential hexose transporter from Candida albicans (see 2 papers)
40% identity, 93% coverage
- CharProtDB CGD description: Putative glucose transporter, major facilitator superfamily; glucose-, fluconazole-, Snf3p-induced, expressed at high glucose; upregulated in biofilm; C. albicans glucose transporter family comprises 20 members; 12 TM regions predicted
SS1G_04841 hexose transporter from Sclerotinia sclerotiorum 1980 UF-70
40% identity, 88% coverage
YJL219W Hxt9p from Saccharomyces cerevisiae
P40885 Hexose transporter HXT9 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
41% identity, 87% coverage
- An inducible CRISPR interference library for genetic interrogation of Saccharomyces cerevisiae biology
Momen-Roknabadi, Communications biology 2020 - “...present in the second replicate, targeting all but five of the yeast ORFs (YBL023C, YIL171W, YJL219W, YOR324C, YPR019W; Fig. 1e and Supplementary Fig. 2 ). The two bacterial replicates are highly correlated (Fig. 1f , Pearson correlation R =0.75). The loss in the number of gRNAs...”
- Transcriptional Comparison Investigating the Influence of the Addition of Unsaturated Fatty Acids on Aroma Compounds During Alcoholic Fermentation
Yan, Frontiers in microbiology 2019 - “...Protein of unknown function 2.42 YCR102C Protein of unknown function 2.06 Early-stationary phase Sugar utilization YJL219W HXT9 Putative hexose transporter that is nearly identical to Hxt11p 3.47 YJL216C IMA5 Alpha-glucosidase 2.78 Unknown function YMR317W Putative protein of unknown function 2.58 YKL068W-A Putative protein of unknown function...”
- “...mannoprotein 2.18 YLR084C RAX2 N-glycosylated protein 2.18 YDR033W MRH1 Membrane protein Related to Hsp30p 2.06 YJL219W HXT9 Putative hexose transporter that is nearly identical to Hxt11p 2.74 YBR092C PHO3 Constitutively expressed acid phosphatase similar to Pho5p 2.08 YGR131W FHN1 Functional Homolog of Nce102 2.01 YBR161W CSH1...”
- Improved Xylose Metabolism by a CYC8 Mutant of Saccharomyces cerevisiae
Nijland, Applied and environmental microbiology 2017 - “...YDR342C YHR092C YHR096C YHR094C YJL214W YDL245C YJR158W YEL069C YFL011W YJL219W YOL156W YLR081W YNL318C Sum of all HXTs Sum of all genes Gene HXT2 HXT36 HXT7...”
- Complete genome sequence and comparative genomics of the probiotic yeast Saccharomyces boulardii
Khatri, Scientific reports 2017 - “...Endosomal ferric enterobactin transporter YOL156W HXT11 Putative hexose transporter that is nearly identical to Hxt9p YJL219W HXT9 Putative hexose transporter that is nearly identical to Hxt11p YOL157C IMA2 Isomaltase YIL172C IMA3 Isomaltase YJL221C IMA4 Isomaltase YGR289C MAL11 High-affinity maltose transporter (alpha-glucoside transporter) YGR288W MAL13 MAL-activator protein...”
- Crucial role of 4-deoxy-L-erythro-5-hexoseulose uronate reductase for alginate utilization revealed by adaptive evolution in engineered Saccharomyces cerevisiae
Matsuoka, Scientific reports 2017 - “...( TEF1p-yopt_kdgK-CYC1t ) and yopt_eda ( TEF1p-yopt_eda-CYC1t ) were introduced into a putative pseudogene ( YJL219w ) site in the genomic DNA of both MK5315 (BY4742 ade2 0 trp1 63 ) and D452-2, creating MK5524 and MK5517. Extracts of the resultant cells (MK5524 and MK5517) produced...”
- Extensive Copy Number Variation in Fermentation-Related Genes Among Saccharomyces cerevisiae Wine Strains
Steenwyk, G3 (Bethesda, Md.) 2017 - “...the HXT gene family ( HXT6 / YDR343C , HXT7 / YDR342C , HXT9 / YJL219W , HXT11 / YOL156W , HXT13 / YEL069C , HXT15 / YDL245C , and HXT17 / YNR072W ), which is involved in sugar transport, that were among the 363 CN...”
- Different Toxicity Mechanisms for Citrinin and Ochratoxin A Revealed by Transcriptomic Analysis in Yeast
Vanacloig-Pedros, Toxins 2016 - “...zinc-finger transcription factor YMR038C CCS1 6.9 6.96 10 5 Copper chaperone for superoxide dismutase Sod1p YJL219W HXT9 6.9 1.67 10 7 Putative hexose transporter YER142C MAG1 6.8 5.46 10 7 3-methyl-adenine DNA glycosylase YBR046C ZTA1 6.7 1.13 10 5 NADPH-dependent quinone reductase YNL231C PDR16 6.6 7.41...”
- Phylogenetic and Transcripts Profiling of Glucose Sensing Related Genes in Candida glabrata
Ng, Jundishapur journal of microbiology 2015 - “...YDR343C DAA12184 570 62.7 HXT7 YDR342C DAA12183 570 62.7 HXT8 YJL214W DAA08597 569 63.5 HXT9 YJL219W DAA08593 567 62.9 HXT10 YFL011W DAA12428 546 60.7 HXT11 YOL156W DAA10630 567 62.7 HXT13 YEL069C DAA07586 564 62.7 HXT14 YNL318C CAA96250 540 61.0 HXT15 YDL245C DAA11622 567 62.9 HXT16 YJR158W...”
- More
- Novel Citronellyl-Based Photoprobes Designed to Identify ER Proteins Interacting with Dolichyl Phosphate in Yeast and Mammalian Cells.
Rush, Current chemical biology 2015 - “...+ Q02785 11 ATP-dependent permease PDR12 + + P54862 11 Hexose transporter HXT11 + + P40885 11 Hexose transporter HXT9 + + P39003 11 High-affinity hexose transporter HXT6 + + P39004 11 High-affinity hexose transporter HXT6 + + P32466 11 Low-affinity glucose transporter HXT3 + +...”
- Optimizing pentose utilization in yeast: the need for novel tools and approaches
Young, Biotechnology for biofuels 2010 - “...TMB3201 + Saccharomyces cerevisiae HXT8 P40886 p4H7 [ 64 ] TMB3201 - Saccharomyces cerevisiae HXT9 P40885 p4H7 [ 64 ] TMB3201 - Saccharomyces cerevisiae HXT10 P43581 p4H7 [ 64 ] TMB3201 - Saccharomyces cerevisiae HXT11 P54862 p426MET25 [ 64 ] TMB3201 - Saccharomyces cerevisiae HXT13 P39924...”
- Major facilitator superfamily
Pao, Microbiology and molecular biology reviews : MMBR 1998 - “...P23585 P32466 P32467 P38695 P39003 P39004 P40886 P43581 P40885 P39924 P42833 P47185 Z71687 P30605 X98622 P30606 S51081 P07921 P38156 P15685 P18631 X96876 Q10710...”
XP_001387898 hexose transporter from Scheffersomyces stipitis CBS 6054
O94155 Sugar transporter 1 from Scheffersomyces stipitis
42% identity, 86% coverage
- Genetic basis of the highly efficient yeast Kluyveromyces marxianus: complete genome sequence and transcriptome analyses
Lertwattanasakul, Biotechnology for biofuels 2015 - “...as follows: Ps_HGT2, XP_001382755; Sc_HXT7, NP_010629; Sc_GAL2, NP_013182; Dh_xylhp, AY347871; Ci_GXS1, GN107181; Ci_GXF1, GN107179; Ps_SUT1, XP_001387898; Ps_SUT2, XP_001384295; Ps_SUT3, XP_001386019; Ps_HXT2.4, XP_001387757; Ps_XUT1, XP_001385583; Ps_XUT2, XP_001387242; Ps_XUT3, XP_001387138; Ps_XUT4, XP_001386715; Ps_XUT5, XP_001385962; Ps_XUT6, XP_001386589; Ps_XUT7, XP_001387067; Ps_RGT2, XP_001386588; Ps_SLT1, XP_001383774; Kl_KHT1/RAG1, XP_453656; Kl_KHT2, GN107317; Kl_KHT3, XP_454897;...”
- Optimizing pentose utilization in yeast: the need for novel tools and approaches.
Young, Biotechnology for biofuels 2010 - “...TMB3201 - Escherichia coli XylE P0AGF4 p4H7 [ 64 ] TMB3201 - Pichia stipitis SUT1 O94155 YEp24 [ 105 ] RE700 - Pichia stipitis SUT2 O94151 YEp24 [ 105 ] RE700 - Pichia stipitis SUT3 Q9UWF5 YEp24 [ 105 ] RE700 - Pichia stipitis Genomic library...”
CPAR2_212860 uncharacterized protein from Candida parapsilosis
41% identity, 87% coverage
- Eukaryotic transporters for hydroxyderivatives of benzoic acid
Cillingová, Scientific reports 2017 - “...level of expression in the control cells grown in synthetic medium containing glucose (SD) was CPAR2_212860 encoding an MFS protein with predicted sugar transporter domain (PF00083/Sugar_tr). Its ortholog in C. albicans is HGT7 (C2_01000W) and codes for a glucose transporter 40 , 41 . We assumed...”
FGSG_02978 hypothetical protein from Fusarium graminearum PH-1
44% identity, 88% coverage
TC 2.A.1.1.6 / P13181 Galactose, glucose uniporter, Gal2. Also transports xylose from Saccharomyces cerevisiae (Baker's yeast) (see 4 papers)
GAL2 / GI|1360445 galactose transporter from Saccharomyces cerevisiae
NP_013182 galactose permease GAL2 from Saccharomyces cerevisiae S288C
NP_013182, YLR081W Gal2p from Saccharomyces cerevisiae
40% identity, 86% coverage
- substrates: Galactose, Xylose, glucose
tcdb comment: This transporter has been engineered by mutation (N376F) to transport xylose without being inhibited by glucose or transporting other hexoses (Farwick et al. 2014). The 3-d structure is known (Wang et al. 2015) - Advances in fungal sugar transporters: unlocking the potential of second-generation bioethanol production
Pereira, Applied microbiology and biotechnology 2025 - “...) HXT13 P39924 Glucose and mannose S. cerevisiae Young et al. ( 2011 ) Gal2 P13181 Glucose, xylose, L-arabinose, galactose, fructose, mannose, and ribose S. cerevisiae Hamacher et al. ( 2002 ); Becker and Boles ( 2003 ); Young et al. ( 2011 ) GXF1 Q2MDH1...”
- The Penicillium chrysogenum transporter PcAraT enables high-affinity, glucose-insensitive l-arabinose transport in Saccharomyces cerevisiae
Bracher, Biotechnology for biofuels 2018 - “...rooted in iTOL ( https://itol.embl.de/ ) [ 54 ]. Gene accession numbers were ScGAL2 : P13181, PcaraT : CAP85508, SsaraT : XP_001382755, Atstp2 : OAP13698, Kmaxt1 : GZ791039, Pgaxt1 : GZ791040, Amlat1 : AY923868, Amlat2 : AY923869, Nclat - 1 : EAA30346, Mtlat - 1 :...”
- “...literature references for each transporter are provided in Table 6 . Accession numbers: Sc Gal2: P13181, Pc AraT: CAP85508, Ss AraT: A3LQQ5-1, At Stp2: OAP13698, Km Axt1: GZ791039, Pg Axt1: GZ791040, Am Lat1: AY923868, Am Lat2: AY923869, Nc Lat-1: EAA30346, Mt Lat-1: G2QFT5-1 l -Arabinose transport...”
- Functional survey for heterologous sugar transport proteins, using Saccharomyces cerevisiae as a host
Young, Applied and environmental microbiology 2011 - “...a EcoRI ClaI XmaI ClaI BamHI-HF ClaI XmaI ClaI P13181 GAL2 S. cerevisiae 3, 38 Introns, Synthesized by Blue Heron Biotechnology EY220 EY221 EY194 EY208 EY159...”
- Optimizing pentose utilization in yeast: the need for novel tools and approaches
Young, Biotechnology for biofuels 2010 - “...TMB3201 - Saccharomyces cerevisiae HXT15 P54854 p4H7 [ 64 ] TMB3201 - Saccharomyces cerevisiae GAL2 P13181 pHL125 [ 64 ] TMB3201 + Several previous studies have evaluated the capacity of selected transport proteins to uptake xylose in yeast. The strain genotype (described in Table 2) used...”
- Major facilitator superfamily
Pao, Microbiology and molecular biology reviews : MMBR 1998 - “...687 555 540 486 457 602 818 569 S59368 P13181 L21753 P49374 P32465 P23585 P32466 P32467 P38695 P39003 P39004 P40886 P43581 P40885 P39924 P42833 P47185 Z71687...”
- “...Th2A of Trypanosoma brucei P37021 P09830 P09098 P21906 P43581 P13181 P11636 P30605 P07921 P15685 S59368 Q07647 U11843 P15686 Q02563 X78855 Q06222 SP SP SP SP SP...”
- Identification of a glucose-insensitive variant of Gal2 from Saccharomyces cerevisiae exhibiting a high pentose transport capacity.
Rojas, Scientific reports 2021 - GeneRIF: Identification of a glucose-insensitive variant of Gal2 from Saccharomyces cerevisiae exhibiting a high pentose transport capacity.
- The regulatory roles of the galactose permease and kinase in the induction response of the GAL network in Saccharomyces cerevisiae.
Hawkins, The Journal of biological chemistry 2006 (PubMed)- GeneRIF: The roles of GAL1 and GAL2 in the activation of the galactose metabolism network of S. cerevisiae are reported.
- The ubiquitin ligase SCF(Grr1) is required for Gal2p degradation in the yeast Saccharomyces cerevisiae.
Horak, Biochemical and biophysical research communications 2005 (PubMed)- GeneRIF: In this study, we show that the other components of SCF(Grr1), including Skp1, Rbx1p, and the ubiquitin-conjugating enzyme Cdc34, are also necessary for glucose-induced Gal2p degradation.
- Phenotypic selection during laboratory evolution of yeast populations leads to a genome-wide sustainable chromatin compaction shift
Moreno, Frontiers in microbiology 2022 - “...alanine tRNA, five of them code for uncharacterized or dubious ORFs (YFL063W, YHR217C, YLL066W-B, YLL065W, YLR081W, and YML122C), and the last one for the plasma membrane permease GIT1 which mediates uptake of glycerophosphoinositol and glycerophosphocholine. Between day10 and day28, during which no selection pressure was applied,...”
- Yeast Double Transporter Gene Deletion Library for Identification of Xenobiotic Carriers in Low or High Throughput
Almeida, mBio 2021 - “...YJL214W, YJR040W, YJR054W, YJR152W, YKL174C, YKL217W, YKR039W, YKR050W, YKR103W, YKR106W, YLL028W, YLL043W, YLL048C, YLL052C, YLL061W, YLR081W, YLR092W, YLR130C, YLR138W, YLR237W, YML047C, YML116W, YML123C, YMR011W, YMR177W, YMR243C, YMR279C, YMR319C, YNL065W, YNL142W, YNL268W, YNL270C, YNL275W, YNL291C, YNL318C, YNR002C, YNR055C, YNR056C, YNR072W, YOL020W, YOL103W, YOL122C, YOL158C, YOR011W, YOR071C, YOR153W,...”
- Improved Xylose Metabolism by a CYC8 Mutant of Saccharomyces cerevisiae
Nijland, Applied and environmental microbiology 2017 - “...YHR096C YHR094C YJL214W YDL245C YJR158W YEL069C YFL011W YJL219W YOL156W YLR081W YNL318C Sum of all HXTs Sum of all genes Gene HXT2 HXT36 HXT7 HXT4 HXT5 HXT1...”
- Extensive Copy Number Variation in Fermentation-Related Genes Among Saccharomyces cerevisiae Wine Strains
Steenwyk, G3 (Bethesda, Md.) 2017 - “...), we also examined the absolute CN of all other 10 members ( GAL2 / YLR081W , HXT1 / YHR094C , HXT2 / YMR011W , HXT4 / YHR092C , HXT5 / YHR096C , HXT8 / YJL214W , HXT10 / YFL011W , HXT16 / YJR158W , RGT2...”
- Multiplexed gene control reveals rapid mRNA turnover
Baudrimont, Science advances 2017 - “...endogenous, substitutional, and insertional promoters. ( B ) Time course of the decay of the YLR081W ( GAL2 ) mRNA driven by its endogenous promoter (shut down by galactose removal; t 1/2 = 2.6 min) or driven by the substitutional promoter ( t 1/2 = 2.6...”
- Genetic basis of the highly efficient yeast Kluyveromyces marxianus: complete genome sequence and transcriptome analyses
Lertwattanasakul, Biotechnology for biofuels 2015 - “...of amino acid sequences of sugar transporters are as follows: Ps_HGT2, XP_001382755; Sc_HXT7, NP_010629; Sc_GAL2, NP_013182; Dh_xylhp, AY347871; Ci_GXS1, GN107181; Ci_GXF1, GN107179; Ps_SUT1, XP_001387898; Ps_SUT2, XP_001384295; Ps_SUT3, XP_001386019; Ps_HXT2.4, XP_001387757; Ps_XUT1, XP_001385583; Ps_XUT2, XP_001387242; Ps_XUT3, XP_001387138; Ps_XUT4, XP_001386715; Ps_XUT5, XP_001385962; Ps_XUT6, XP_001386589; Ps_XUT7, XP_001387067; Ps_RGT2, XP_001386588;...”
- Conservation of replication timing reveals global and local regulation of replication origin activity
Müller, Genome research 2012 - “...genome. Second, we noted that one of the genes adjacent to ARS1212 ( GAL2 / YLR081W ) is duplicated in S. bayanus , raising the possibility that ARS1212 is also duplicated (Supplemental Fig. S18). The presence of two close origins could then account for the observed...”
- Positional analyses of BRCA1-dependent expression in Saccharomyces cerevisiae
Skibbens, Cell cycle (Georgetown, Tex.) 2008 - “...Up 14.4041395 Up YBR020W GAL1 76.735115 Up 166.01247 Up YBR019C GAL10 78.75131 Up 53.76265 Up YLR081W GAL2 101.56116 Up 93.95381 Up YPL248C GAL4 36.34818 Up 46.29145 Up YBR018C GAL7 5.330396 Up 4.0937595 Up YDR019C GCV1 2.5090592 Up 2.682127 Up YPR184W GDB1 4.222917 Up 3.8256583 Up YAL062W...”
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Q9UWF5 Sugar transporter 3 from Scheffersomyces stipitis
XP_001386019 Sugar UpTake (tentative) from Scheffersomyces stipitis CBS 6054
43% identity, 87% coverage
- Optimizing pentose utilization in yeast: the need for novel tools and approaches.
Young, Biotechnology for biofuels 2010 - “...RE700 - Pichia stipitis SUT2 O94151 YEp24 [ 105 ] RE700 - Pichia stipitis SUT3 Q9UWF5 YEp24 [ 105 ] RE700 - Pichia stipitis Genomic library [ 105 ] - YEp24 [ 64 ] TMB3201 - Trichoderma reesei Xlt1 Q1EG32 pAJ401 [ 66 ] H2219 +*...”
- Genetic basis of the highly efficient yeast Kluyveromyces marxianus: complete genome sequence and transcriptome analyses
Lertwattanasakul, Biotechnology for biofuels 2015 - “...Sc_HXT7, NP_010629; Sc_GAL2, NP_013182; Dh_xylhp, AY347871; Ci_GXS1, GN107181; Ci_GXF1, GN107179; Ps_SUT1, XP_001387898; Ps_SUT2, XP_001384295; Ps_SUT3, XP_001386019; Ps_HXT2.4, XP_001387757; Ps_XUT1, XP_001385583; Ps_XUT2, XP_001387242; Ps_XUT3, XP_001387138; Ps_XUT4, XP_001386715; Ps_XUT5, XP_001385962; Ps_XUT6, XP_001386589; Ps_XUT7, XP_001387067; Ps_RGT2, XP_001386588; Ps_SLT1, XP_001383774; Kl_KHT1/RAG1, XP_453656; Kl_KHT2, GN107317; Kl_KHT3, XP_454897; Kl_FRT1, XP_454356; Kl_HGT1, XP_451484;...”
O94151 Sugar transporter 2 protein from Scheffersomyces stipitis
XP_001384295 sugar transporter from Scheffersomyces stipitis CBS 6054
43% identity, 87% coverage
- Optimizing pentose utilization in yeast: the need for novel tools and approaches.
Young, Biotechnology for biofuels 2010 - “...TMB3201 - Pichia stipitis SUT1 O94155 YEp24 [ 105 ] RE700 - Pichia stipitis SUT2 O94151 YEp24 [ 105 ] RE700 - Pichia stipitis SUT3 Q9UWF5 YEp24 [ 105 ] RE700 - Pichia stipitis Genomic library [ 105 ] - YEp24 [ 64 ] TMB3201 -...”
- Genetic basis of the highly efficient yeast Kluyveromyces marxianus: complete genome sequence and transcriptome analyses
Lertwattanasakul, Biotechnology for biofuels 2015 - “...Ps_HGT2, XP_001382755; Sc_HXT7, NP_010629; Sc_GAL2, NP_013182; Dh_xylhp, AY347871; Ci_GXS1, GN107181; Ci_GXF1, GN107179; Ps_SUT1, XP_001387898; Ps_SUT2, XP_001384295; Ps_SUT3, XP_001386019; Ps_HXT2.4, XP_001387757; Ps_XUT1, XP_001385583; Ps_XUT2, XP_001387242; Ps_XUT3, XP_001387138; Ps_XUT4, XP_001386715; Ps_XUT5, XP_001385962; Ps_XUT6, XP_001386589; Ps_XUT7, XP_001387067; Ps_RGT2, XP_001386588; Ps_SLT1, XP_001383774; Kl_KHT1/RAG1, XP_453656; Kl_KHT2, GN107317; Kl_KHT3, XP_454897; Kl_FRT1, XP_454356;...”
Q1K4S3 Hexose transporter HXT13 from Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
NCU01633 hexose transporter HXT13 from Neurospora crassa OR74A
41% identity, 95% coverage
- Advances in fungal sugar transporters: unlocking the potential of second-generation bioethanol production
Pereira, Applied microbiology and biotechnology 2025 - “...( 2017a ) HGT-2 Q7S3Q4 Glucose N. crassa Wang et al. ( 2017a ) GLT-1 Q1K4S3 Glucose and xylose N. crassa Li et al. ( 2014 ); Wang et al. ( 2017a ) NCU00809 Q7SEC5 Lactose N. crassa Tamayo et al. ( 2024 ) CdtC S8AIR7...”
- Do mitochondria use efflux pumps to protect their ribosomes from antibiotics?
Islam, Microbiology (Reading, England) 2023 - “...NCU05226 Q7S8I2 ABC O42765, 7.8E^6 A0A1P8ATY7, 6.7E^12 Q8WW24, 1.4E^14 [ 79, 112 ] HXT13, NCU01633 Q1K4S3 MFS Q8J2J7, 2.1E^85 P23586, 1.2E^52 P11168, 2.6E^48 [ 79 ] NCU04809 Q756M6 MFS T2AWG3, 0.0014 Q8GYF4, 1.4E^24 B3KT41, 0.0022 [ 79 ] NCU09551 Q7S2B0 MFS G1UAY0, 2.3E^6 Q56ZZ7, 2.3E^7 Q8NBP5,...”
- Revisiting 2-Deoxyglucose Resistance in Neurospora crassa: Insights into Transcriptional Regulation of Hexose Transporters, Sugar Metabolism and Possible Modulation by Mating Type
Pandey, 2023 - Do mitochondria use efflux pumps to protect their ribosomes from antibiotics?
Islam, Microbiology (Reading, England) 2023 - “...] NCU05226 Q7S8I2 ABC O42765, 7.8E^6 A0A1P8ATY7, 6.7E^12 Q8WW24, 1.4E^14 [ 79, 112 ] HXT13, NCU01633 Q1K4S3 MFS Q8J2J7, 2.1E^85 P23586, 1.2E^52 P11168, 2.6E^48 [ 79 ] NCU04809 Q756M6 MFS T2AWG3, 0.0014 Q8GYF4, 1.4E^24 B3KT41, 0.0022 [ 79 ] NCU09551 Q7S2B0 MFS G1UAY0, 2.3E^6 Q56ZZ7, 2.3E^7...”
- The F-box protein gene exo-1 is a target for reverse engineering enzyme hypersecretion in filamentous fungi
Gabriel, Proceedings of the National Academy of Sciences of the United States of America 2021 (secret) - Transcriptional Profiling of Myceliophthora thermophila on Galactose and Metabolic Engineering for Improved Galactose Utilization
Wang, Frontiers in microbiology 2021 - “...and most likely, it is the major galactose transporter in this fungus, of which ortholog (NCU01633, glt-1 ) in N. crassa has been identified as a glucose transporter and also has the capability of transportation of multiple other monosaccharides, including galactose ( Li et al., 2014...”
- Evaluating the circadian rhythm and response to glucose addition in dispersed growth cultures of Neurospora crassa
Kelliher, Fungal biology 2020 - “...genome, three genes were recently identified and characterized as major components of System I: glt-1 (NCU01633), and of System II: hgt-1 and hgt-2 (NCU10021 and NCU04963) ( Wang et al., 2017 ). The K m values for all three transporters fall within the ranges of earlier...”
- Identification and characterization of the glucose dual-affinity transport system in Neurospora crassa: pleiotropic roles in nutrient transport, signaling, and carbon catabolite repression
Wang, Biotechnology for biofuels 2017 - “...dual-affinity transport system in the model fungus N. crassa . One low-affinity glucose transporter, GLT-1 (NCU01633), and two high-affinity transporters, HGT-1/-2 (NCU10021 and NCU04963), were identified as the major components of systems I and II, respectively. Simultaneous deletion of hgt - 1/ - 2 (strain 2hgt...”
- Neurospora crassa transcriptomics reveals oxidative stress and plasma membrane homeostasis biology genes as key targets in response to chitosan
Lopez-Moya, Molecular bioSystems 2016 - “...other genes related with sugars assimilation were also induces in presence of chitosan such as NCU01633 ( hxt13 ; Table S2 ). Clusters 2M and 3M, had gene expression changes in the control but not in the chitosan treatment ( Figs. 4B and 4C ). Genes...”
- Involvement of the adaptor protein 3 complex in lignocellulase secretion in Neurospora crassa revealed by comparative genomic screening
Pei, Biotechnology for biofuels 2015 - “...alcohol oxidase 616.825.92 7.26 61 15869 NCU00335 jgi|Trire2|5140| Pre-mRNA-splicing factor cwc15 612.1815.31 6.51 62 13160 NCU01633 jgi|Trire2|62380| Hexose transporter HXT13 611.2919.85 6.33 63 19733 NCU06832 jgi|Trire2|112231| Kinesin 609.845.91 5.93 64 12341 NCU09864 jgi|Trire2|56726| 2-Oxoisovalerate dehydrogenase alpha subunit 608.184.15 5.88 65 11030 NCU07788 jgi|Trire2|52368| Fungal specific transcription...”
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HGT6 potential hexose transporter from Candida albicans (see 2 papers)
40% identity, 91% coverage
- CharProtDB CGD description: Putative glucose transporter of major facilitator superfamily; 20 members of C. albicans glucose transporter family; 12 probable membrane-spanning segments; core stress response, fluconazole-induced; expressed in rich medium with 2% glucose
HXT8_YEAST / P40886 Hexose transporter HXT8 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
YJL214W Hxt8p from Saccharomyces cerevisiae
41% identity, 86% coverage
- function: Probable glucose transporter
- Yeast Double Transporter Gene Deletion Library for Identification of Xenobiotic Carriers in Low or High Throughput
Almeida, mBio 2021 - “...YGR281W, YGR289C, YHL016C, YHL040C, YHL047C, YHR092C, YHR094C, YHR096C, YIL013C, YIL088C, YIL120W, YIL121W, YJL093C, YJL129C, YJL212C, YJL214W, YJR040W, YJR054W, YJR152W, YKL174C, YKL217W, YKR039W, YKR050W, YKR103W, YKR106W, YLL028W, YLL043W, YLL048C, YLL052C, YLL061W, YLR081W, YLR092W, YLR130C, YLR138W, YLR237W, YML047C, YML116W, YML123C, YMR011W, YMR177W, YMR243C, YMR279C, YMR319C, YNL065W, YNL142W, YNL268W,...”
- Improved Xylose Metabolism by a CYC8 Mutant of Saccharomyces cerevisiae
Nijland, Applied and environmental microbiology 2017 - “...CYC8(Y353) Probe YMR011W YDR343C YDR342C YHR092C YHR096C YHR094C YJL214W YDL245C YJR158W YEL069C YFL011W YJL219W YOL156W YLR081W YNL318C Sum of all HXTs Sum of...”
- Extensive Copy Number Variation in Fermentation-Related Genes Among Saccharomyces cerevisiae Wine Strains
Steenwyk, G3 (Bethesda, Md.) 2017 - “..., HXT2 / YMR011W , HXT4 / YHR092C , HXT5 / YHR096C , HXT8 / YJL214W , HXT10 / YFL011W , HXT16 / YJR158W , RGT2 / YDL138W , and SNF3 / YDL194W ) of the HXT gene family ( Figure 3 ). Interestingly, all remaining...”
- Phylogenetic and Transcripts Profiling of Glucose Sensing Related Genes in Candida glabrata
Ng, Jundishapur journal of microbiology 2015 - “...YHR096C DAA06790 592 66.3 HXT6 YDR343C DAA12184 570 62.7 HXT7 YDR342C DAA12183 570 62.7 HXT8 YJL214W DAA08597 569 63.5 HXT9 YJL219W DAA08593 567 62.9 HXT10 YFL011W DAA12428 546 60.7 HXT11 YOL156W DAA10630 567 62.7 HXT13 YEL069C DAA07586 564 62.7 HXT14 YNL318C CAA96250 540 61.0 HXT15 YDL245C...”
- The switch from fermentation to respiration in Saccharomyces cerevisiae is regulated by the Ert1 transcriptional activator/repressor
Gasmi, Genetics 2014 - “...YKR093W QDR3 PHD1 -- HXT8 YBR043C YLR043W YLR044W YJL214W IMA5 PMA1 TKL1 DIP5 YJL216C YGL008C YPR074C YPL265W ATO2 HAP4 YNR002C YKL109W GID8 YMR135C FMP43...”
- “...in highly purified mitochondria in high-throughput studies YKL044W YJL214W IMA5 YJL216C PMA1 YGL008C TKL1 YPR074C DSF1 YEL070W DIP5 YPL265W - YGR161W-C Unknown...”
- Transcriptomic profiling of the Saccharomyces cerevisiae response to quinine reveals a glucose limitation response attributable to drug-induced inhibition of glucose uptake
dos, Antimicrobial agents and chemotherapy 2009 - “...Membrane transport YCL025c YHR094c YMR011w YDR345c YHR092c YHR096c YJL214w YFL011w YKL217w YHL036w YML123c YCR037c YBR106w YBR296c YFL054c -- -- S R -- S --...”
- Phospholipid transfer protein Sec14 is required for trafficking from endosomes and regulates distinct trans-Golgi export pathways
Curwin, The Journal of biological chemistry 2009 - “...YER149C YLR429W YIL090W PER1 YCR044C DSD1 HXT8 YGL196W YJL214W LSM1 CBF1 YJL124C YJR060W RAD27 YKL113C EAF7 RAD34 YSA1 CUE3 YNL136W YDR314C YBR111C YGL110C...”
- Regulatory network connecting two glucose signal transduction pathways in Saccharomyces cerevisiae
Kaniak, Eukaryotic cell 2004 - “...YER028C YGL039W YKL035W YOL016C YHR087W YMR316W YER062C YJL214W YBR105C YDR423C YHR097C YOL046C YBR067C YDR277C YOL136C YFL054C YDR001C YPL026C YLR413W YDL062W...”
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- Optimizing pentose utilization in yeast: the need for novel tools and approaches
Young, Biotechnology for biofuels 2010 - “...TMB3201 + Saccharomyces cerevisiae HXT7 P39004 YEpkHXT7 [ 64 ] TMB3201 + Saccharomyces cerevisiae HXT8 P40886 p4H7 [ 64 ] TMB3201 - Saccharomyces cerevisiae HXT9 P40885 p4H7 [ 64 ] TMB3201 - Saccharomyces cerevisiae HXT10 P43581 p4H7 [ 64 ] TMB3201 - Saccharomyces cerevisiae HXT11 P54862...”
- Major facilitator superfamily
Pao, Microbiology and molecular biology reviews : MMBR 1998 - “...P49374 P32465 P23585 P32466 P32467 P38695 P39003 P39004 P40886 P43581 P40885 P39924 P42833 P47185 Z71687 P30605 X98622 P30606 S51081 P07921 P38156 P15685 P18631...”
KLMA_50361 hexose transporter 2 from Kluyveromyces marxianus DMKU3-1042
42% identity, 87% coverage
XP_447265 hypothetical protein from Candida glabrata CBS 138
43% identity, 85% coverage
- Phylogenetic and Transcripts Profiling of Glucose Sensing Related Genes in Candida glabrata
Ng, Jundishapur journal of microbiology 2015 - “...XP_444803 549 61.6 HXT2/10 CAGL0D02662 XP_445530 564 62.4 HXT2/10 CAGL0D02640 XP_445530 564 62.4 HXT2/10 CAGL0I00286 XP_447265 555 61.7 HXT14 CAGL0M04103 XP_449525 531 59.0 Table 2. Details of Glucose Sensing-Related Genes of Saccharomyces cerevisiae Target Gene Name Systematic Name Accession Number No. of Amino Acids Molecular Mass,...”
XP_444845 hypothetical protein from Candida glabrata CBS 138
43% identity, 93% coverage
P18631 Low-affinity glucose transporter from Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
XP_453656 hypothetical protein from Kluyveromyces lactis NRRL Y-1140
41% identity, 84% coverage
- Major facilitator superfamily
Pao, Microbiology and molecular biology reviews : MMBR 1998 - “...P47185 Z71687 P30605 X98622 P30606 S51081 P07921 P38156 P15685 P18631 X96876 Q10710 P38142 S58778 U32274 P43562 Z72626 P40441 P47186 P10870 P39932 GB SP GB SP...”
- Genetic basis of the highly efficient yeast Kluyveromyces marxianus: complete genome sequence and transcriptome analyses
Lertwattanasakul, Biotechnology for biofuels 2015 - “...Ps_XUT3, XP_001387138; Ps_XUT4, XP_001386715; Ps_XUT5, XP_001385962; Ps_XUT6, XP_001386589; Ps_XUT7, XP_001387067; Ps_RGT2, XP_001386588; Ps_SLT1, XP_001383774; Kl_KHT1/RAG1, XP_453656; Kl_KHT2, GN107317; Kl_KHT3, XP_454897; Kl_FRT1, XP_454356; Kl_HGT1, XP_451484; Kl_HXT1, XP_455078; Kl_HXT14, XP_454897; Kl_HXT2, XP_453960; Kl_HXT3, XP_453088; Sc_HXT4/LGT1, NP_011960; Kl_STL1, XP_456249; Kl_RAG4, XP_455315; Kl_LAC12, XP_452193; Ca_HXT6, XP_719472. Genes for the initial...”
- Comparative genomics of the white-rot fungi, Phanerochaete carnosa and P. chrysosporium, to elucidate the genetic basis of the distinct wood types they colonize
Suzuki, BMC genomics 2012 - “...CaHgt4 (XP_723173), CaHgt11 (XP_719597), CiGxf1 (AJ937350), CiGxs1 (AJ875406), GzHyp1 (EAA74528), HpGcr1 (AAR88143), KlHgt1 (XP_451484), KlRag1 (XP_453656), KlRag4 (CAA75114), Lb_EDR07962 (EDR07962), NcHyp1 (XP_328858), NcHxt3 (CAD21508), NcNCU00801(EAA34565.1), NcNCU08114 (XP_963873.1), NcRco3 (CAE76420), Pp_115604 (EED81359), Ps_ABN65648.2 (ABN65648.2), PsSut1 (AAD00266), ScHxt1 (M82963), ScHxt7 (NP_010629), ScSnf3 (P10870), SpGht1 (Q9P3U6), Tm-CAZ81962.1 (CAZ81962.1), TrHxt1...”
- Catabolite repression of Aox in Pichia pastoris is dependent on hexose transporter PpHxt1 and pexophagy
Zhang, Applied and environmental microbiology 2010 - “...for ScHxt7, AAU43755 for ScGal2, P53387 for KlKht2, XP_453656 for KlRag1, XP_719598 for CaHgt7, XP_001387898 for PsSut1, CAI77652 for CiGxf1, EU476006 for...”
- Identification of hexose transporter-like sensor HXS1 and functional hexose transporter HXT1 in the methylotrophic yeast Hansenula polymorpha
Stasyk, Eukaryotic cell 2008 - “...HpGcr1, AAR88143; HpHxt1, EU476006; HpHxs1, EU476007; KlRag1, XP_453656; KlRag4, CAA75114; ScHxt1, M82963; ScSnf3, NP_010087; and ScRgt2, NP_010143. 740 STASYK...”
TRIREDRAFT_106556 galactose permease from Trichoderma reesei QM6a
G0RGR7 Galactose permease from Hypocrea jecorina (strain QM6a)
40% identity, 92% coverage
- Effect of the res2 transcription factor gene deletion on protein secretion and stress response in the hyperproducer strain Trichoderma reesei Rut-C30
Alharake, BMC microbiology 2023 - “...the condition LC/GC in res2 but not regulated in Rut-C30, such as low-affinity glucose transporter TRIREDRAFT_106556 ( hxt13 ), TRIREDRAFT_62747, and TRIREDRAFT_47897 which is involved in the oxidative stress response. One MFS transporter in this cluster is downregulated in the mutant (TRIREDRAFT_58561). On the other hand,...”
- “...hydrolase family 55 LC/GC -2.17 6 TRIREDRAFT_121746 Putative Glycoside hydrolase family 55 GD/GC -2.20 6 TRIREDRAFT_106556 hxt13 hexose transporter GD/GC LD/LC LC/GC 5.08 3.14 6.67 4 TRIREDRAFT_62747 MFS membrane transporter LC/GC 3.16 4 TRIREDRAFT_47897 snq2 ABC transporter involved in oxidative stress response GD/GC LC/GC 2.08 3.17...”
- Advances in fungal sugar transporters: unlocking the potential of second-generation bioethanol production.
Pereira, Applied microbiology and biotechnology 2025 - “...Glucose, xylose, fructose, galactose, and mannose T. reesei Sloothaak et al. ( 2016b ) GLT1 G0RGR7 Glucose T. reesei Havukainen et al. ( 2021b ) STP1 G0RIJ1 Glucose, fructose, galactose, mannose, cellobiose, xylose, and L-arabinose T. reesei Zhang et al. ( 2013 ); Wang et al....”
KLMA_50363 low-affinity glucose transporter from Kluyveromyces marxianus DMKU3-1042
42% identity, 84% coverage
HXT6 / GI|1230670 high-affinity hexose transporter HXT6 from Saccharomyces cerevisiae
YDR343C High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3 from Saccharomyces cerevisiae
NP_010630 hexose transporter HXT6 from Saccharomyces cerevisiae S288C
P39003 High-affinity hexose transporter HXT6 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
41% identity, 86% coverage
- Overexpression of THI4 and HAP4 Improves Glucose Metabolism and Ethanol Production in Saccharomyces cerevisiae
Shi, Frontiers in microbiology 2018 - “...Gene ID Gene name Primer sequences (53) YFL039C ACT1 F: TGGATTCCGGTGATGGTGTT (conference gene) R: TGGCGTGAGGTAGAGAGAAACC YDR343C HXT6 F: CGCTGCTATTGCAGAGCAAAC R: CGAGTGGGAGGCTGAGTCA YGR144W THI4 F: TTTGCCGTTTCTGACGTGATT R: GCGGCGGATAAACCTGAA YFL058W THI5 F: GGTTACTTCAAGGAGCAAGGTCTAGA R: CAGTGACATCGGAAGGATTGG YKL109W HAP4 F: TGTACCGATCGCCCCAAATA R: TGCCATCGTTTTCGAATTCC YJL208C NUC1 F: TCGATCCTTCCGGGTTCTT R: CGCGGTTCTGCAGATCATG YDL022W...”
- Improved Xylose Metabolism by a CYC8 Mutant of Saccharomyces cerevisiae
Nijland, Applied and environmental microbiology 2017 - “...carrying CYC8(Y353) and CYC8(Y353C)a CYC8(Y353) Probe YMR011W YDR343C YDR342C YHR092C YHR096C YHR094C YJL214W YDL245C YJR158W YEL069C YFL011W YJL219W YOL156W...”
- Extensive Copy Number Variation in Fermentation-Related Genes Among Saccharomyces cerevisiae Wine Strains
Steenwyk, G3 (Bethesda, Md.) 2017 - “...File S2 ). We identified seven members of the HXT gene family ( HXT6 / YDR343C , HXT7 / YDR342C , HXT9 / YJL219W , HXT11 / YOL156W , HXT13 / YEL069C , HXT15 / YDL245C , and HXT17 / YNR072W ), which is involved in...”
- Overexpression of a Water-Forming NADH Oxidase Improves the Metabolism and Stress Tolerance of Saccharomyces cerevisiae in Aerobic Fermentation
Shi, Frontiers in microbiology 2016 - “...TGGATTCCGGTGATGGTGTT R: TGGCGTGAGGTAGAGAGAAACC L196579 noxE F: TCAAAAATGGCGCAATCAAG R: CCGCGTAAACATCTGGATCA YJR158W Hxt16 F: TTTGAGCAACGTGCGTATGG R: CGCCAATGGAACATCCTACA YDR343C HXT6 F: CGCTGCTATTGCAGAGCAAAC R: CGAGTGGGAGGCTGAGTCA YGR144W THI4 F: TTTGCCGTTTCTGACGTGATT R: GCGGCGGATAAACCTGAA YFL058W THI5 F: GGTTACTTCAAGGAGCAAGGTCTAGA R: CAGTGACATCGGAAGGATTGG YJR156C THI11 F: CAAGAAGGCAACCGACTACGT R: GAGGCTTGAAGTCGATGTATTCTTT YNL332W THI12 F: GGTTACTTCAAGGAGCAAGGTCTAGA R: CAGTGACATCGGAAGGATTGG YDL244W...”
- A water-forming NADH oxidase regulates metabolism in anaerobic fermentation
Shi, Biotechnology for biofuels 2016 (no snippet) - Understanding the Role of the Master Regulator XYR1 in Trichoderma reesei by Global Transcriptional Analysis
Dos, Frontiers in microbiology 2016 - “...acid sequences of transporters from T. reesei and other species ( Saccharomyces cerevisiae YHR094C, YHR092C, YDR343C; Neurospora crassa NCU00821, NCU04963, NCU08114, NCU10021; Aspergillus nidulans AN3199, AN6831; Aspergillus oryzae AO090103000130, AO090038000233; Aspergillus niger XP_001397059.2; Escherichia coli YP006127731.1; Metarhizium anisopliae GQ167043.1, EFY97396.1, EFY94560.1; Talaromyces marneffei XP002152585.1; Talaromyces stipitatus...”
- Phylogenetic and Transcripts Profiling of Glucose Sensing Related Genes in Candida glabrata
Ng, Jundishapur journal of microbiology 2015 - “...YDR345C DAA12185 567 62.6 HXT4 YHR092C DAA06788 576 63.9 HXT5 YHR096C DAA06790 592 66.3 HXT6 YDR343C DAA12184 570 62.7 HXT7 YDR342C DAA12183 570 62.7 HXT8 YJL214W DAA08597 569 63.5 HXT9 YJL219W DAA08593 567 62.9 HXT10 YFL011W DAA12428 546 60.7 HXT11 YOL156W DAA10630 567 62.7 HXT13 YEL069C...”
- Genetics of single-cell protein abundance variation in large yeast populations
Albert, Nature 2014 - “...We noticed two clear outliers in terms of estimated purity. First, the pools for gene YDR343C ( HXT6 ) had 5060% of reads mapping to the gene YDR342C ( HXT7 ). These two genes are close paralogs, and both the ends of their ORFs and their...”
- “...sequences. Off-target reads are therefore expected at 25% of reads for YGR192C. We retained both YDR343C and YGR192C in our analyses. The remaining genes with apparent contamination have low absolute numbers of reads overlapping the cassette fusions so that a single off-target read has a disproportionate...”
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- Multilevel regulation of an α-arrestin by glucose depletion controls hexose transporter endocytosis.
Hovsepian, The Journal of cell biology 2017 - GeneRIF: Two glucose signaling pathways converge onto Csr2 to regulate hexose transporter Hxt6 endocytosis by glucose availability.
- Regulation of the Yeast Hxt6 Hexose Transporter by the Rod1 α-Arrestin, the Snf1 Protein Kinase, and the Bmh2 14-3-3 Protein.
Llopis-Torregrosa, The Journal of biological chemistry 2016 - GeneRIF: demonstrated the interaction of Rod1 with Hxt6 and showed that the localization of the Rod1-Hxt6 complex at the plasma membrane is affected by carbon source and is reduced upon overexpression of SNF1 and BMH2
- Reciprocal sign epistasis between frequently experimentally evolved adaptive mutations causes a rugged fitness landscape.
Kvitek, PLoS genetics 2011 - GeneRIF: Variation in the copy number of HXT6/HTX7 locus was observed in a survey of ~70 yeast strains.
- Components of the Vid30c are needed for the rapamycin-induced degradation of the high-affinity hexose transporter Hxt7p in Saccharomyces cerevisiae.
Snowdon, FEMS yeast research 2008 (PubMed)- GeneRIF: Three members of the VID and GID gene families, VID30/GID1, GID2, and VID28/GID5 are needed for the rapamycin or nitrogen starvation-induced degradation of the high-affinity hexose transporter Hxt7p is shown here.
- Advances in fungal sugar transporters: unlocking the potential of second-generation bioethanol production
Pereira, Applied microbiology and biotechnology 2025 - “...S. cerevisiae Reifenberger et al. ( 1995 ); Apel et al. ( 2016 ) HXT6 P39003 Glucose, fructose, and mannose S. cerevisiae Reifenberger et al. ( 1995 ) HXT7 P39004 Glucose, xylose, galactose, fructose, and mannose S. cerevisiae Young et al. ( 2011 ) HXT13 P39924...”
- Novel Citronellyl-Based Photoprobes Designed to Identify ER Proteins Interacting with Dolichyl Phosphate in Yeast and Mammalian Cells.
Rush, Current chemical biology 2015 - “...+ P54862 11 Hexose transporter HXT11 + + P40885 11 Hexose transporter HXT9 + + P39003 11 High-affinity hexose transporter HXT6 + + P39004 11 High-affinity hexose transporter HXT6 + + P32466 11 Low-affinity glucose transporter HXT3 + + P32467 11 Low-affinity glucose transporter HXT4 +...”
- Rapid response of the yeast plasma membrane proteome to salt stress
Szopinska, Molecular & cellular proteomics : MCP 2011 - “...PM PM PM PM and MT P23291 P38250 P39004 P39003 P38695 P32467 P32466 P23585 P32465 P06775 P53154 P10823 P08539 P38631 Q08193 Q03655 P22146 P38196 P40088 Q12333...”
- Major facilitator superfamily
Pao, Microbiology and molecular biology reviews : MMBR 1998 - “...P13181 L21753 P49374 P32465 P23585 P32466 P32467 P38695 P39003 P39004 P40886 P43581 P40885 P39924 P42833 P47185 Z71687 P30605 X98622 P30606 S51081 P07921 P38156...”
HXT7_YEAST / P39004 High-affinity hexose transporter HXT7 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
TC 2.A.1.1.31 / P39004 High affinity, glucose-repressible, glucose (hexose) uniporter (Hxt6/Hxt7). Asn331 and hydrophobic residue side chains in TMS5 determine substrate affinity from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 6 papers)
NP_010629, YDR342C High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels from Saccharomyces cerevisiae
NP_010629 hexose transporter HXT7 from Saccharomyces cerevisiae S288C
41% identity, 86% coverage
- function: High-affinity glucose transporter
- substrates: Hexoses
tcdb comment: Also transports xylose (Effect of Isomixing on Grape Must Fermentations of ATF1-Overexpressing Wine Yeast Strains
van, Foods (Basel, Switzerland) 2020 - “...1578-bp ATF1 open reading frame (ORF; YOR377w and HXT7 promoter (1000 bp upstream of ORF YDR342c)) was amplified using Phusion Taq polymerase (Thermo Scientific, Waltham, MA, USA) from genomic DNA of S. cerevisiae VIN13 using the primers listed in Table S1 . The amplicon containing ATF1...”
- Improved Xylose Metabolism by a CYC8 Mutant of Saccharomyces cerevisiae
Nijland, Applied and environmental microbiology 2017 - “...CYC8(Y353) and CYC8(Y353C)a CYC8(Y353) Probe YMR011W YDR343C YDR342C YHR092C YHR096C YHR094C YJL214W YDL245C YJR158W YEL069C YFL011W YJL219W YOL156W YLR081W...”
- Extensive Copy Number Variation in Fermentation-Related Genes Among Saccharomyces cerevisiae Wine Strains
Steenwyk, G3 (Bethesda, Md.) 2017 - “...identified seven members of the HXT gene family ( HXT6 / YDR343C , HXT7 / YDR342C , HXT9 / YJL219W , HXT11 / YOL156W , HXT13 / YEL069C , HXT15 / YDL245C , and HXT17 / YNR072W ), which is involved in sugar transport, that were...”
- Genetic basis of the highly efficient yeast Kluyveromyces marxianus: complete genome sequence and transcriptome analyses
Lertwattanasakul, Biotechnology for biofuels 2015 - “...accession numbers of amino acid sequences of sugar transporters are as follows: Ps_HGT2, XP_001382755; Sc_HXT7, NP_010629; Sc_GAL2, NP_013182; Dh_xylhp, AY347871; Ci_GXS1, GN107181; Ci_GXF1, GN107179; Ps_SUT1, XP_001387898; Ps_SUT2, XP_001384295; Ps_SUT3, XP_001386019; Ps_HXT2.4, XP_001387757; Ps_XUT1, XP_001385583; Ps_XUT2, XP_001387242; Ps_XUT3, XP_001387138; Ps_XUT4, XP_001386715; Ps_XUT5, XP_001385962; Ps_XUT6, XP_001386589; Ps_XUT7, XP_001387067;...”
- Phylogenetic and Transcripts Profiling of Glucose Sensing Related Genes in Candida glabrata
Ng, Jundishapur journal of microbiology 2015 - “...YHR092C DAA06788 576 63.9 HXT5 YHR096C DAA06790 592 66.3 HXT6 YDR343C DAA12184 570 62.7 HXT7 YDR342C DAA12183 570 62.7 HXT8 YJL214W DAA08597 569 63.5 HXT9 YJL219W DAA08593 567 62.9 HXT10 YFL011W DAA12428 546 60.7 HXT11 YOL156W DAA10630 567 62.7 HXT13 YEL069C DAA07586 564 62.7 HXT14 YNL318C...”
- Lipid droplet dynamics in budding yeast
Wang, Cellular and molecular life sciences : CMLS 2015 - “...W V N Histone H2B HXT6/7 YDR343C/ YDR342C V PM/M High-affinity glucose transporter IDP3 YNL009W V C/P/M Peroxisomal NADP-dependent isocitrate dehydrogenase...”
- Genetics of single-cell protein abundance variation in large yeast populations
Albert, Nature 2014 - “...pools for gene YDR343C ( HXT6 ) had 5060% of reads mapping to the gene YDR342C ( HXT7 ). These two genes are close paralogs, and both the ends of their ORFs and their downstream sequence are virtually identical, suggesting that the apparent contamination is in...”
- Transferring functional annotations of membrane transporters on the basis of sequence similarity and sequence motifs
Barghash, BMC bioinformatics 2013 - “...will term the normalized BLAST results "normalized E-values". As an example, we BLASTed Sc transporter YDR342C either against the At dataset (23,567 residues) or against the non-redundant (nr) database of 2011 with 3,877,139,759 residues. Among the matching sequences, we identified the Arabidopsis transporter At3g19940 in both...”
- More
- Regulation of Hxt3 and Hxt7 turnover converges on the Vid30 complex and requires inactivation of the Ras/cAMP/PKA pathway in Saccharomyces cerevisiae.
Snowdon, PloS one 2012 - GeneRIF: turnover of both Hxt3 and Hxt7 is dependent on the essential E3 ubiquitin ligase, Rsp5, indicating that the role of the Vid30c might be indirect of Hxt ubiquitylation
- Reciprocal sign epistasis between frequently experimentally evolved adaptive mutations causes a rugged fitness landscape.
Kvitek, PLoS genetics 2011 - GeneRIF: Variation in the copy number of HXT6/HTX7 locus was observed in a survey of ~70 yeast strains.
- Crucial effects of amino acid side chain length in transmembrane segment 5 on substrate affinity in yeast glucose transporter Hxt7.
Kasahara, Biochemistry 2011 (PubMed)- GeneRIF: The amino acid side chain length in transmembrane segment 5 of HXT7 is important for glucose affinity.
- Identification of a key residue determining substrate affinity in the yeast glucose transporter Hxt7: a two-dimensional comprehensive study.
Kasahara, The Journal of biological chemistry 2010 - GeneRIF: Asp(340) is situated at or close to a substrate recognition site and is a key residue determining high-affinity glucose transport by Hxt7
- Enhanced arsenic accumulation in Saccharomyces cerevisiae overexpressing transporters Fps1p or Hxt7p.
Shah, Journal of biotechnology 2010 (PubMed)- GeneRIF: Saccharomyces cerevisiae was engineered for enhanced arsenite accumulation by overexpression of transporters responsible for the influx of the contaminant. The transporter genes FPS1 and HXT7 were cloned under the control of the late-phase ADH2-promoter.
- Cell growth restoration and high level protein expression by the promoter of hexose transporter, HXT7, from Saccharomyces cerevisiae.
Lai, Biotechnology letters 2007 (PubMed)- GeneRIF: promoter produces higher invertase activity at 139- and 30-fold of the basal activity in strains GN 3C.2 and W303-1, respectively
- Characterization of the effectiveness of hexose transporters for transporting xylose during glucose and xylose co-fermentation by a recombinant Saccharomyces yeast.
Sedlak, Yeast (Chichester, England) 2004 (PubMed)- GeneRIF: Saccharomyces galactose transporter system could be a highly effective xylose transporter. The information reported here should be of great importance for improving the Saccharomyces yeast transport of xylose.
- Advances in fungal sugar transporters: unlocking the potential of second-generation bioethanol production
Pereira, Applied microbiology and biotechnology 2025 - “...HXT6 P39003 Glucose, fructose, and mannose S. cerevisiae Reifenberger et al. ( 1995 ) HXT7 P39004 Glucose, xylose, galactose, fructose, and mannose S. cerevisiae Young et al. ( 2011 ) HXT13 P39924 Glucose and mannose S. cerevisiae Young et al. ( 2011 ) Gal2 P13181 Glucose,...”
- Yeast α-arrestin Art2 is the key regulator of ubiquitylation-dependent endocytosis of plasma membrane vitamin B1 transporters
Savocco, PLoS biology 2019 - “...P32791 FRE1 0.31 P32466 HXT3 0.35 P38085 TAT1 0.38 Q06689 INA1 0.41 P32465 HXT1 0.42 P39004 HXT7 0.44 P32467 HXT4 0.48 P38079 YRO2 0.55 P40088 FTR1 0.55 P05030 PMA1 0.58 Q12256 TPO4 0.58 P38993 FET3 0.60 P49573 CTR1 0.63 P40474 QDR2 0.64 P22146 GAS1 0.74 P33302...”
- “...0.3 P32465 HXT1 4.6 2.8 4.4 9.3 2.6 1.6 2.2 1.8 1.7 2.4 1.4 1.9 P39004 HXT7 0.6 0.4 0.3 1.1 0.6 0.2 0.9 0.6 0.1 0.7 0.1 0.4 P32467 HXT4 0.7 0.6 0.6 2.8 0.5 0.6 0.7 0.5 0.4 0.6 0.2 0.5 P38079 YRO2 3.9...”
- Novel Citronellyl-Based Photoprobes Designed to Identify ER Proteins Interacting with Dolichyl Phosphate in Yeast and Mammalian Cells.
Rush, Current chemical biology 2015 - “...P40885 11 Hexose transporter HXT9 + + P39003 11 High-affinity hexose transporter HXT6 + + P39004 11 High-affinity hexose transporter HXT6 + + P32466 11 Low-affinity glucose transporter HXT3 + + P32467 11 Low-affinity glucose transporter HXT4 + + Q03516 11 Uncharacterized protein RSN1 + P53154...”
- Functional survey for heterologous sugar transport proteins, using Saccharomyces cerevisiae as a host
Young, Applied and environmental microbiology 2011 - “...enzymes and primers used. 15, 36 P39924 HXT13 15, 36 P39004 HXT7 15, 36 P32466 HXT4 a EcoRI ClaI XmaI ClaI BamHI-HF ClaI XmaI ClaI P13181 GAL2 S. cerevisiae...”
- Rapid response of the yeast plasma membrane proteome to salt stress
Szopinska, Molecular & cellular proteomics : MCP 2011 - “...PM PM PM PM PM and MT P23291 P38250 P39004 P39003 P38695 P32467 P32466 P23585 P32465 P06775 P53154 P10823 P08539 P38631 Q08193 Q03655 P22146 P38196 P40088...”
- Optimizing pentose utilization in yeast: the need for novel tools and approaches
Young, Biotechnology for biofuels 2010 - “...H2219 + Saccharomyces cerevisiae HXT4 P32467 pYX212 [ 66 ] H2219 + Saccharomyces cerevisiae HXT7 P39004 pYX212 [ 66 ] H2219 + Saccharomyces cerevisiae HXT1 P32465 p4H7 [ 64 ] TMB3201 - Saccharomyces cerevisiae HXT3 P32466 p4H7 [ 64 ] TMB3201 - Saccharomyces cerevisiae HXT4 P32467...”
- “...TMB3201 + Saccharomyces cerevisiae HXT5 P38695 p4H7 [ 64 ] TMB3201 + Saccharomyces cerevisiae HXT7 P39004 YEpkHXT7 [ 64 ] TMB3201 + Saccharomyces cerevisiae HXT8 P40886 p4H7 [ 64 ] TMB3201 - Saccharomyces cerevisiae HXT9 P40885 p4H7 [ 64 ] TMB3201 - Saccharomyces cerevisiae HXT10 P43581...”
- Major facilitator superfamily
Pao, Microbiology and molecular biology reviews : MMBR 1998 - “...L21753 P49374 P32465 P23585 P32466 P32467 P38695 P39003 P39004 P40886 P43581 P40885 P39924 P42833 P47185 Z71687 P30605 X98622 P30606 S51081 P07921 P38156 P15685...”
NP_011964 hexose transporter HXT5 from Saccharomyces cerevisiae S288C
P38695 Probable glucose transporter HXT5 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
YHR096C Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs from Saccharomyces cerevisiae
44% identity, 80% coverage
- Differential regulation of glucose transport activity in yeast by specific cAMP signatures.
Bermejo, The Biochemical journal 2013 (PubMed)- GeneRIF: During starvation, yeast cells anticipate exposure to glucose by activating the hexose glucose transporter (Hxt)5p, which provides an advantage during early phases after glucose resupply.
- Degradation of the hexose transporter Hxt5p in Saccharomyces cerevisiae.
van, Biology of the cell 2007 (PubMed)- GeneRIF: These results suggest that internalization and degradation of Hxt5p in the vacuole occur in an ubiquitination-independent manner via the endocytic pathway.
- Advances in fungal sugar transporters: unlocking the potential of second-generation bioethanol production
Pereira, Applied microbiology and biotechnology 2025 - “...S. cerevisiae Reifenberger et al. ( 1995 ); Apel et al. ( 2016 ) HXT5 P38695 Glucose, xylose, fructose, and mannose S. cerevisiae Reifenberger et al. ( 1995 ); Apel et al. ( 2016 ) HXT6 P39003 Glucose, fructose, and mannose S. cerevisiae Reifenberger et al....”
- Rapid response of the yeast plasma membrane proteome to salt stress
Szopinska, Molecular & cellular proteomics : MCP 2011 - “...PM PM PM and MT P23291 P38250 P39004 P39003 P38695 P32467 P32466 P23585 P32465 P06775 P53154 P10823 P08539 P38631 Q08193 Q03655 P22146 P38196 P40088 Q12333...”
- Optimizing pentose utilization in yeast: the need for novel tools and approaches
Young, Biotechnology for biofuels 2010 - “...TMB3201 - Saccharomyces cerevisiae HXT4 P32467 p4H7 [ 64 ] TMB3201 + Saccharomyces cerevisiae HXT5 P38695 p4H7 [ 64 ] TMB3201 + Saccharomyces cerevisiae HXT7 P39004 YEpkHXT7 [ 64 ] TMB3201 + Saccharomyces cerevisiae HXT8 P40886 p4H7 [ 64 ] TMB3201 - Saccharomyces cerevisiae HXT9 P40885...”
- Major facilitator superfamily
Pao, Microbiology and molecular biology reviews : MMBR 1998 - “...S59368 P13181 L21753 P49374 P32465 P23585 P32466 P32467 P38695 P39003 P39004 P40886 P43581 P40885 P39924 P42833 P47185 Z71687 P30605 X98622 P30606 S51081 P07921...”
- DebaryOmics: an integrative -omics study to understand the halophilic behaviour of Debaryomyces hansenii
Navarrete, Microbial biotechnology 2022 - “...transport of mannose YHR094C DEHA2E04224g YES NO HXT5 Hexose transporter with moderate affinity for glucose YHR096C DEHA2D18876g YES YES RRS1 Regulator of ribosome biosynthesis YOR294W DEHA2F09834g NO NO BFR2 Involved in endoplasmic reticulum to Golgi transport YDR299W DEHA2A14212g NO NO HSP30 Negative regulator of the H+ATPase...”
- A Genome-Wide Screen in Saccharomyces cerevisiae Reveals a Critical Role for Oxidative Phosphorylation in Cellular Tolerance to Lithium Hexafluorophosphate
Jin, Cells 2021 - “...0.00035 0.5810 0.00003 0.5751 0.00002 cytoplasm YLR436C ECM30 0.2724 0.00002 0.4312 0.00000 0.4328 0.00002 cytoplasm YHR096C HXT5 0.2206 0.00004 0.2280 0.00002 0.2911 0.00003 - YBL021C HAP3 0.3353 0.00082 0.2217 0.00000 0.3064 0.00000 cytoplasm, nucleus YNL229C URE2 0.2639 0.00012 0.3145 0.00001 0.2208 0.00000 cytoplasm Protein Synthesis and...”
- Yeast Double Transporter Gene Deletion Library for Identification of Xenobiotic Carriers in Low or High Throughput
Almeida, mBio 2021 - “...YGL114W, YGL255W, YGR055W, YGR121C, YGR138C, YGR217W, YGR224W, YGR260W, YGR281W, YGR289C, YHL016C, YHL040C, YHL047C, YHR092C, YHR094C, YHR096C, YIL013C, YIL088C, YIL120W, YIL121W, YJL093C, YJL129C, YJL212C, YJL214W, YJR040W, YJR054W, YJR152W, YKL174C, YKL217W, YKR039W, YKR050W, YKR103W, YKR106W, YLL028W, YLL043W, YLL048C, YLL052C, YLL061W, YLR081W, YLR092W, YLR130C, YLR138W, YLR237W, YML047C, YML116W, YML123C,...”
- “...( 54 ). In the Y7092 background, the same plasma membrane transporter-encoding genes (except YEL063C, YHR096C, and YOR202W) were replaced with the nat MX marker ( 49 ). In the library construction, strains containing deletions of genes not related to transport (YAL060W, YDR073W, and YIR002C) were...”
- Transcriptional Comparison Investigating the Influence of the Addition of Unsaturated Fatty Acids on Aroma Compounds During Alcoholic Fermentation
Yan, Frontiers in microbiology 2019 - “...name Description Fold change Mid-exponential phase Glucose transportation Hexose transporter with moderate affinity for glucose YHR096C HXT5 0.45 Zinc ion homeostasis YOL101C IZH4 Membrane protein involved in zinc ion homeostasis 0.28 Other process YBR067C TIP1 Major cell wall mannoprotein with possible lipase activity 0.47 YDL223C HBT1...”
- Improved Xylose Metabolism by a CYC8 Mutant of Saccharomyces cerevisiae
Nijland, Applied and environmental microbiology 2017 - “...CYC8(Y353C)a CYC8(Y353) Probe YMR011W YDR343C YDR342C YHR092C YHR096C YHR094C YJL214W YDL245C YJR158W YEL069C YFL011W YJL219W YOL156W YLR081W YNL318C Sum of all...”
- Extensive Copy Number Variation in Fermentation-Related Genes Among Saccharomyces cerevisiae Wine Strains
Steenwyk, G3 (Bethesda, Md.) 2017 - “..., HXT1 / YHR094C , HXT2 / YMR011W , HXT4 / YHR092C , HXT5 / YHR096C , HXT8 / YJL214W , HXT10 / YFL011W , HXT16 / YJR158W , RGT2 / YDL138W , and SNF3 / YDL194W ) of the HXT gene family ( Figure 3...”
- Transcriptional profiling reveals molecular basis and novel genetic targets for improved resistance to multiple fermentation inhibitors in Saccharomyces cerevisiae
Chen, Biotechnology for biofuels 2016 - “...YCR021C , YDR011W, YDR135C, YDR345C , YER060W, YGL255W, YGR065C, YGR138C , YGR260W, YGR281W, YHL036W, YHR092C, YHR096C , YKL175W, YKR039W, YLL028W, YLR130C, YLR237W, YML116W, YOL119C, YOR153W, YOR306C, YOR328W, YPL036W, YPL058C, YPL274W YBR054W , YCL025C, YCR021C , YDR345C , YER103W, YGR138C , YHR094C, YHR096C , YPL036W YBL075C, YBR008C,...”
- “...YCR021C , YDR011W, YDR046C, YDR135C, YDR345C , YDR497C, YER103W, YFL054C, YGL255W, YGR138C , YGR281W, YHR092C, YHR096C , YJR095W, YKL175W, YLL028W, YLR237W, YLR259C, YML116W, YOR153W, YOR328W, YPL058C, YPL274W, YPR138C, YPR156C Ion transport (GO: 0006811) YAL053W, YBR054W, YCL025C, YCR021C , YDR135C, YGL255W, YGR065C, YGR138C, YGR142W, YGR260W, YHL036W, YKL165C,...”
- Phylogenetic and Transcripts Profiling of Glucose Sensing Related Genes in Candida glabrata
Ng, Jundishapur journal of microbiology 2015 - “...YMR011W DAA09909 541 59.8 HXT3 YDR345C DAA12185 567 62.6 HXT4 YHR092C DAA06788 576 63.9 HXT5 YHR096C DAA06790 592 66.3 HXT6 YDR343C DAA12184 570 62.7 HXT7 YDR342C DAA12183 570 62.7 HXT8 YJL214W DAA08597 569 63.5 HXT9 YJL219W DAA08593 567 62.9 HXT10 YFL011W DAA12428 546 60.7 HXT11 YOL156W...”
- More
TC 2.A.1.1.67 / Q2MDH1 Glucose/xylose facilitator-1, GXF1 (functions by sugar uniport; low affinity from Candida intermedia (see paper)
gxf1 / CAI77652.1 glucose/xylose facilitator 1 from [Candida] intermedia (see paper)
41% identity, 87% coverage
- substrates: Xylose, glucose
- Advances in fungal sugar transporters: unlocking the potential of second-generation bioethanol production.
Pereira, Applied microbiology and biotechnology 2025 - “...2002 ); Becker and Boles ( 2003 ); Young et al. ( 2011 ) GXF1 Q2MDH1 Glucose, xylose, galactose, fructose, and mannose C. intermedia Leandro et al. ( 2006 ); Young et al. ( 2011 ) GXS1 Q2MEV7 Glucose, xylose, galactose, fructose, mannose, and ribose C....”
- Optimizing pentose utilization in yeast: the need for novel tools and approaches.
Young, Biotechnology for biofuels 2010 - “...Seedling cDNA [ 104 ] - pFL61 [ 64 ] TMB3201 - Candida intermedia Gxf1 Q2MDH1 YEplac195 [ 72 ] TMB3201 + Candida intermedia Gxs1 Q2MEV7 YEplac195 [ 72 ] TMB3201 + Chlorella kessleri Hup1 P15686 p4H7 [ 64 ] TMB3201 - Escherichia coli XylE P0AGF4...”
XP_444860 hypothetical protein from Candida glabrata CBS 138
42% identity, 85% coverage
KLMA_50364 low-affinity glucose transporter from Kluyveromyces marxianus DMKU3-1042
41% identity, 88% coverage
XP_444843 hypothetical protein from Candida glabrata CBS 138
42% identity, 85% coverage
- Phylogenetic and Transcripts Profiling of Glucose Sensing Related Genes in Candida glabrata
Ng, Jundishapur journal of microbiology 2015 - “...CAG57729 424 46.4 HXT1 CAGL0A01804 CAG57737 563 62.3 HXT3 CAGL0A02321 CAG57758 556 61.5 HXT4 CAGL0A01782 XP_444843 568 62.9 HXT5 CAGL0A01826 CAG57738 588 65.7 HXT4/6/7 CAGL0A02233 XP_444861 549 61.2 HXT6/7 CAGL0A02211 XP_444860 552 61.5 HXT6/7 CAGL0A00737 XP_444803 549 61.6 HXT2/10 CAGL0D02662 XP_445530 564 62.4 HXT2/10 CAGL0D02640 XP_445530...”
NP_011960, YHR092C High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose from Saccharomyces cerevisiae
42% identity, 87% coverage
- Functional analysis of a Phytophthora host-translocated effector using the yeast model system
Wilson, PeerJ 2021 - “...(YDR384C) Putative ammonium transporter; possible role in export of ammonia from the cell 1.1 HXT4 (YHR092C) High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose 1.0 NFG1 (YLR042C) Cell wall protein of...”
- “...Term size Query size Intersecting genes GO:0005353 Fructose transmembrane transporter activity 2.43 15 4 YDR345C, YHR092C GO:0015578 Mannose transmembrane transporter activity 2.43 15 4 YDR345C, YHR092C TF:M00061_0 Factor: Mig1p; motif: KANWWWWATSYGGGGWA; match class: 0 2.83 74 6 YDR345C, YDR384C, YHR092C Notes: Gene set enrichment analysis using...”
- Low Toxicological Impact of Commercial Pristine Multi-Walled Carbon Nanotubes on the Yeast Saccharomyces cerevisiae
Martel, Nanomaterials (Basel, Switzerland) 2021 - “...in different biological processes, such as metal ion homeostasis: FRE1 (YLR214W), utilization of carbon: HXT4 (YHR092C), nitrogen: ICR7 (YFR055W), and sulfur sources: SAM3 (YPL274W); purine biosynthesis and accumulation: ADE4 and FCY2 (YMR300C and YER056C); and ER-associated protein degradation: MNS1 (YJR131W). FRE1 produces a cell-surface iron reductase...”
- Yeast Double Transporter Gene Deletion Library for Identification of Xenobiotic Carriers in Low or High Throughput
Almeida, mBio 2021 - “...YFL055W, YGL077C, YGL114W, YGL255W, YGR055W, YGR121C, YGR138C, YGR217W, YGR224W, YGR260W, YGR281W, YGR289C, YHL016C, YHL040C, YHL047C, YHR092C, YHR094C, YHR096C, YIL013C, YIL088C, YIL120W, YIL121W, YJL093C, YJL129C, YJL212C, YJL214W, YJR040W, YJR054W, YJR152W, YKL174C, YKL217W, YKR039W, YKR050W, YKR103W, YKR106W, YLL028W, YLL043W, YLL048C, YLL052C, YLL061W, YLR081W, YLR092W, YLR130C, YLR138W, YLR237W, YML047C,...”
- Improved Xylose Metabolism by a CYC8 Mutant of Saccharomyces cerevisiae
Nijland, Applied and environmental microbiology 2017 - “...and CYC8(Y353C)a CYC8(Y353) Probe YMR011W YDR343C YDR342C YHR092C YHR096C YHR094C YJL214W YDL245C YJR158W YEL069C YFL011W YJL219W YOL156W YLR081W YNL318C Sum of...”
- Extensive Copy Number Variation in Fermentation-Related Genes Among Saccharomyces cerevisiae Wine Strains
Steenwyk, G3 (Bethesda, Md.) 2017 - “...( GAL2 / YLR081W , HXT1 / YHR094C , HXT2 / YMR011W , HXT4 / YHR092C , HXT5 / YHR096C , HXT8 / YJL214W , HXT10 / YFL011W , HXT16 / YJR158W , RGT2 / YDL138W , and SNF3 / YDL194W ) of the HXT gene...”
- Transcriptional profiling reveals molecular basis and novel genetic targets for improved resistance to multiple fermentation inhibitors in Saccharomyces cerevisiae
Chen, Biotechnology for biofuels 2016 - “...YCL025C, YCR021C , YDR011W, YDR135C, YDR345C , YER060W, YGL255W, YGR065C, YGR138C , YGR260W, YGR281W, YHL036W, YHR092C, YHR096C , YKL175W, YKR039W, YLL028W, YLR130C, YLR237W, YML116W, YOL119C, YOR153W, YOR306C, YOR328W, YPL036W, YPL058C, YPL274W YBR054W , YCL025C, YCR021C , YDR345C , YER103W, YGR138C , YHR094C, YHR096C , YPL036W YBL075C,...”
- “...YBR069C, YCR021C , YDR011W, YDR046C, YDR135C, YDR345C , YDR497C, YER103W, YFL054C, YGL255W, YGR138C , YGR281W, YHR092C, YHR096C , YJR095W, YKL175W, YLL028W, YLR237W, YLR259C, YML116W, YOR153W, YOR328W, YPL058C, YPL274W, YPR138C, YPR156C Ion transport (GO: 0006811) YAL053W, YBR054W, YCL025C, YCR021C , YDR135C, YGL255W, YGR065C, YGR138C, YGR142W, YGR260W, YHL036W,...”
- Acetylated Deoxynivalenol Generates Differences of Gene Expression that Discriminate Trichothecene Toxicity
Suzuki, Toxins 2016 - “...sensor YHR094C HXT1 plasma membrane Low-affinity glucose transporter YMR011W HXT2 plasma membrane High-affinity glucose transporter YHR092C HXT4 plasma membrane High-affinity glucose transporter The gene expression of RGT1 , RGT2 , and SNF3 , which encode a component of a transcriptional regulator complex and glucose sensors, showed...”
- Understanding the Role of the Master Regulator XYR1 in Trichoderma reesei by Global Transcriptional Analysis
Dos, Frontiers in microbiology 2016 - “...amino acid sequences of transporters from T. reesei and other species ( Saccharomyces cerevisiae YHR094C, YHR092C, YDR343C; Neurospora crassa NCU00821, NCU04963, NCU08114, NCU10021; Aspergillus nidulans AN3199, AN6831; Aspergillus oryzae AO090103000130, AO090038000233; Aspergillus niger XP_001397059.2; Escherichia coli YP006127731.1; Metarhizium anisopliae GQ167043.1, EFY97396.1, EFY94560.1; Talaromyces marneffei XP002152585.1; Talaromyces...”
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XP_444803 hypothetical protein from Candida glabrata CBS 138
42% identity, 87% coverage
- Phylogenetic and Transcripts Profiling of Glucose Sensing Related Genes in Candida glabrata
Ng, Jundishapur journal of microbiology 2015 - “...CAG57738 588 65.7 HXT4/6/7 CAGL0A02233 XP_444861 549 61.2 HXT6/7 CAGL0A02211 XP_444860 552 61.5 HXT6/7 CAGL0A00737 XP_444803 549 61.6 HXT2/10 CAGL0D02662 XP_445530 564 62.4 HXT2/10 CAGL0D02640 XP_445530 564 62.4 HXT2/10 CAGL0I00286 XP_447265 555 61.7 HXT14 CAGL0M04103 XP_449525 531 59.0 Table 2. Details of Glucose Sensing-Related Genes of...”
HXT1 / P32465 low-affinity glucose/mannose transporter HXT1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 65 papers)
HXT1_YEAST / P32465 Low-affinity glucose transporter HXT1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
TC 2.A.1.1.108 / P32465 Low-affinity glucose transporter HXT1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 9 papers)
NP_011962 hexose transporter HXT1 from Saccharomyces cerevisiae S288C
NP_011962, YHR094C Hxt1p from Saccharomyces cerevisiae
41% identity, 87% coverage
- function: Low-affinity glucose transporter. HXT1 is as well involved in the transport of mannose
- substrates: glucose
- Advances in fungal sugar transporters: unlocking the potential of second-generation bioethanol production
Pereira, Applied microbiology and biotechnology 2025 - “...) MtCDT-2 G2Q6B1 Xylobiose and cellobiose M. thermophila Liu et al. ( 2024 ) HXT1 P32465 Glucose, xylose, fructose, and mannose S. cerevisiae Reifenberger et al. ( 1995 ); Apel et al. ( 2016 ) HXT2 P23585 Glucose, xylose, fructose, and mannose S. cerevisiae Reifenberger et...”
- Yeast α-arrestin Art2 is the key regulator of ubiquitylation-dependent endocytosis of plasma membrane vitamin B1 transporters
Savocco, PLoS biology 2019 - “...Q01896 ENA2 0.24 P32791 FRE1 0.31 P32466 HXT3 0.35 P38085 TAT1 0.38 Q06689 INA1 0.41 P32465 HXT1 0.42 P39004 HXT7 0.44 P32467 HXT4 0.48 P38079 YRO2 0.55 P40088 FTR1 0.55 P05030 PMA1 0.58 Q12256 TPO4 0.58 P38993 FET3 0.60 P49573 CTR1 0.63 P40474 QDR2 0.64 P22146...”
- “...1.6 Q06689 INA1 1.2 0.9 1.6 0.8 0.8 0.4 0.8 0.4 0.5 0.7 0.1 0.3 P32465 HXT1 4.6 2.8 4.4 9.3 2.6 1.6 2.2 1.8 1.7 2.4 1.4 1.9 P39004 HXT7 0.6 0.4 0.3 1.1 0.6 0.2 0.9 0.6 0.1 0.7 0.1 0.4 P32467 HXT4 0.7...”
- Relationship between Metabolic Fluxes and Sequence-Derived Properties of Enzymes
Zikmanis, International scholarly research notices 2014 (no snippet) - Mutations in SLC2A2 gene reveal hGLUT2 function in pancreatic β cell development
Michau, The Journal of biological chemistry 2013 - “...GLUT2; Q102R8 for zebrafish (Danio rerio) GLUT2; P32465 for yeast (Saccharomyces cerevisiae) HXT1; and Q9FRL3 for plant (Arabidopsis thaliana) sugar transporter...”
- Rapid response of the yeast plasma membrane proteome to salt stress
Szopinska, Molecular & cellular proteomics : MCP 2011 - “...P23291 P38250 P39004 P39003 P38695 P32467 P32466 P23585 P32465 P06775 P53154 P10823 P08539 P38631 Q08193 Q03655 P22146 P38196 P40088 Q12333 P32791 P23900 Q07651...”
- Optimizing pentose utilization in yeast: the need for novel tools and approaches
Young, Biotechnology for biofuels 2010 - “...TMB3201 - Trichoderma reesei Xlt1 Q1EG32 pAJ401 [ 66 ] H2219 +* Saccharomyces cerevisiae HXT1 P32465 pYX212 [ 66 ] H2219 + Saccharomyces cerevisiae HXT2 P23585 pYX212 [ 66 ] H2219 + Saccharomyces cerevisiae HXT4 P32467 pYX212 [ 66 ] H2219 + Saccharomyces cerevisiae HXT7 P39004...”
- Major facilitator superfamily
Pao, Microbiology and molecular biology reviews : MMBR 1998 - “...486 457 602 818 569 S59368 P13181 L21753 P49374 P32465 P23585 P32466 P32467 P38695 P39003 P39004 P40886 P43581 P40885 P39924 P42833 P47185 Z71687 P30605 X98622...”
- Local Anesthetics and Antipsychotic Phenothiazines Interact Nonspecifically with Membranes and Inhibit Hexose Transporters in Yeast.
Uesono, Genetics 2016 - GeneRIF: Local anesthetics and antipsychotic phenothiazine inhibit uptake of glucose by interacting nonspecifically with hexose transporter HXT1
- Assessing glucose uptake through the yeast hexose transporter 1 (Hxt1).
Roy, PloS one 2015 - GeneRIF: Results show that Hxt1 transports 2-NBDG in a mechanism similar to human glucose transporters and, that some of the putative glucose-binding residues of Hxt1 are involved in endocytosis with N370 residue as critical for its stability and function.
- Psy2 targets the PP4 family phosphatase Pph3 to dephosphorylate Mth1 and repress glucose transporter gene expression.
Ma, Molecular and cellular biology 2014 - GeneRIF: Data show that Pph3-Psy2 targets the glucose signal transducer protein Mth1, which is required for the dephosphorylation of Rgt1 upon glucose withdrawal, a critical event in the repression of HXT genes, which encode glucose transporters.
- Expression of the glucose transporter HXT1 involves the Ser-Thr protein phosphatase Sit4 in Saccharomyces cerevisiae.
Souza, FEMS yeast research 2012 (PubMed)- GeneRIF: Association of the HXT1 mRNA with polysomes is regulated by SIT4.
- Different signalling pathways mediate glucose induction of SUC2, HXT1 and pyruvate decarboxylase in yeast.
Belinchón, FEMS yeast research 2007 (PubMed)- GeneRIF: Hxk2 is required for the high expression of HXT1.
- TOR kinase pathway and 14-3-3 proteins regulate glucose-induced expression of HXT1, a yeast low-affinity glucose transporter.
Tomás-Cobos, Yeast (Chichester, England) 2005 (PubMed)- GeneRIF: TOR kinase pathway participates actively in the induction of HXT1 expression by glucose. Inhibition of the TOR kinase pathway by rapamycin treatment abolishes HXT1 glucose induction.
- Furfural tolerance of mutant Saccharomyces cerevisiae selected via ionizing radiation combined with adaptive laboratory evolution
Ren, Biotechnology for biofuels and bioproducts 2024 - “...RPA12 229.45 4.64 RNA polymerase I subunit A12.2 YNL112W DBP2 1399.74 4.67 ATP-dependent RNA helicase YHR094C HXT1 237.18 3.35 Low-affinity glucose transporter YKL166C TPK3 75.28 1.76 cAMP-dependent protein kinase catalytic subunit YGR087C PDC6 0.97 2.12 Minor isoform of pyruvate decarboxylase YKL029C MAE1 118.05 2.60 Mitochondrial malic...”
- DebaryOmics: an integrative -omics study to understand the halophilic behaviour of Debaryomyces hansenii
Navarrete, Microbial biotechnology 2022 - “...NO HXT1 Lowaffinity glucose transporter. HXT1 is as well involved in the transport of mannose YHR094C DEHA2E04224g YES NO HXT5 Hexose transporter with moderate affinity for glucose YHR096C DEHA2D18876g YES YES RRS1 Regulator of ribosome biosynthesis YOR294W DEHA2F09834g NO NO BFR2 Involved in endoplasmic reticulum to...”
- Yeast Double Transporter Gene Deletion Library for Identification of Xenobiotic Carriers in Low or High Throughput
Almeida, mBio 2021 - “...YGL077C, YGL114W, YGL255W, YGR055W, YGR121C, YGR138C, YGR217W, YGR224W, YGR260W, YGR281W, YGR289C, YHL016C, YHL040C, YHL047C, YHR092C, YHR094C, YHR096C, YIL013C, YIL088C, YIL120W, YIL121W, YJL093C, YJL129C, YJL212C, YJL214W, YJR040W, YJR054W, YJR152W, YKL174C, YKL217W, YKR039W, YKR050W, YKR103W, YKR106W, YLL028W, YLL043W, YLL048C, YLL052C, YLL061W, YLR081W, YLR092W, YLR130C, YLR138W, YLR237W, YML047C, YML116W,...”
- Identification of the Genetic Requirements for Zinc Tolerance and Toxicity in Saccharomyces cerevisiae
Zhao, G3 (Bethesda, Md.) 2020 - “...GOS1 YLR242C ARV1 YMR243C ZRC1 YDR186C SND1 YHR026W VMA16 YKL080W VMA5 YNL323W LEM3 YDR276C PMP3 YHR094C HXT1 YKL119C VPH2 YOR270C VPH1 YDR456W NHX1 YHR108W GGA2 YKR020W VPS51 YPL045W VPS16 Unclassified proteins (15) YCL007C YHR112C YKL044W MMO1 YNL204C SPS18 YDL041W YHR151C MTC6 YLR149C YPL261C YDR203W YJL211C YLR232W...”
- Improved Xylose Metabolism by a CYC8 Mutant of Saccharomyces cerevisiae
Nijland, Applied and environmental microbiology 2017 - “...CYC8(Y353) Probe YMR011W YDR343C YDR342C YHR092C YHR096C YHR094C YJL214W YDL245C YJR158W YEL069C YFL011W YJL219W YOL156W YLR081W YNL318C Sum of all HXTs...”
- Extensive Copy Number Variation in Fermentation-Related Genes Among Saccharomyces cerevisiae Wine Strains
Steenwyk, G3 (Bethesda, Md.) 2017 - “...the absolute CN of all other 10 members ( GAL2 / YLR081W , HXT1 / YHR094C , HXT2 / YMR011W , HXT4 / YHR092C , HXT5 / YHR096C , HXT8 / YJL214W , HXT10 / YFL011W , HXT16 / YJR158W , RGT2 / YDL138W , and...”
- Acetylated Deoxynivalenol Generates Differences of Gene Expression that Discriminate Trichothecene Toxicity
Suzuki, Toxins 2016 - “...plasma membrane Plasma membrane glucose sensor YDL194W SNF3 plasma membrane Plasma membrane low glucose sensor YHR094C HXT1 plasma membrane Low-affinity glucose transporter YMR011W HXT2 plasma membrane High-affinity glucose transporter YHR092C HXT4 plasma membrane High-affinity glucose transporter The gene expression of RGT1 , RGT2 , and SNF3...”
- Transcriptional profiling reveals molecular basis and novel genetic targets for improved resistance to multiple fermentation inhibitors in Saccharomyces cerevisiae
Chen, Biotechnology for biofuels 2016 - “...YOR306C, YOR328W, YPL036W, YPL058C, YPL274W YBR054W , YCL025C, YCR021C , YDR345C , YER103W, YGR138C , YHR094C, YHR096C , YPL036W YBL075C, YBR008C, YBR054W , YBR069C, YCR021C , YDR011W, YDR046C, YDR135C, YDR345C , YDR497C, YER103W, YFL054C, YGL255W, YGR138C , YGR281W, YHR092C, YHR096C , YJR095W, YKL175W, YLL028W, YLR237W, YLR259C,...”
- More
HXT4_YEAST / P32467 Low-affinity glucose transporter HXT4; Low-affinity glucose transporter LGT1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
TC 2.A.1.1.30 / P32467 Low affinity, constitutive, glucose (hexose; xylose) uniporter, Hxt4 (LGT1; Rag1) (also transports arsenic trioxide [As(OH)3] as do Hxtl, 3, 5, 7 and 9) from Saccharomyces cerevisiae (Baker's yeast) (see 5 papers)
HXT4 low-affinity glucose transporter HXT4 from Saccharomyces cerevisiae (see paper)
NP_011960 hexose transporter HXT4 from Saccharomyces cerevisiae S288C
43% identity, 83% coverage
- function: Low-affinity glucose transporter. Can also transport xylose.
- substrates: Xylose, glucose
tcdb comment: The Kluyveromyces lactis ortholog is 73% identical and is similarly regulated (Rolland et al. 2006) - Advances in fungal sugar transporters: unlocking the potential of second-generation bioethanol production
Pereira, Applied microbiology and biotechnology 2025 - “...S. cerevisiae Reifenberger et al. ( 1995 ); Apel et al. ( 2016 ) HXT4 P32467 Glucose, xylose, fructose and mannose S. cerevisiae Reifenberger et al. ( 1995 ); Apel et al. ( 2016 ) HXT5 P38695 Glucose, xylose, fructose, and mannose S. cerevisiae Reifenberger et...”
- Yeast α-arrestin Art2 is the key regulator of ubiquitylation-dependent endocytosis of plasma membrane vitamin B1 transporters
Savocco, PLoS biology 2019 - “...P32466 HXT3 0.35 P38085 TAT1 0.38 Q06689 INA1 0.41 P32465 HXT1 0.42 P39004 HXT7 0.44 P32467 HXT4 0.48 P38079 YRO2 0.55 P40088 FTR1 0.55 P05030 PMA1 0.58 Q12256 TPO4 0.58 P38993 FET3 0.60 P49573 CTR1 0.63 P40474 QDR2 0.64 P22146 GAS1 0.74 P33302 PDR5 0.84 P32568...”
- “...1.9 P39004 HXT7 0.6 0.4 0.3 1.1 0.6 0.2 0.9 0.6 0.1 0.7 0.1 0.4 P32467 HXT4 0.7 0.6 0.6 2.8 0.5 0.6 0.7 0.5 0.4 0.6 0.2 0.5 P38079 YRO2 3.9 1.2 2.8 1.2 1.5 0.6 2.0 1.1 0.4 1.5 1.7 0.5 P40088 FTR1 2.2...”
- Study of the Plasma Membrane Proteome Dynamics Reveals Novel Targets of the Nitrogen Regulation in Yeast
Villers, Molecular & cellular proteomics : MCP 2017 - “...P41948 P33413 P06775 P32901 P50276 Other transporters P32467 P38227 P33302 Plasma membrane ATPase P05030 Components of eisosomes and microdomains MCC P53252...”
- Novel Citronellyl-Based Photoprobes Designed to Identify ER Proteins Interacting with Dolichyl Phosphate in Yeast and Mammalian Cells.
Rush, Current chemical biology 2015 - “...11 High-affinity hexose transporter HXT6 + + P32466 11 Low-affinity glucose transporter HXT3 + + P32467 11 Low-affinity glucose transporter HXT4 + + Q03516 11 Uncharacterized protein RSN1 + P53154 10 Glycerol uptake protein 1 GUP1 + P40441 10 Putative hexose transporter 12 HXT12 + +...”
- Rapid response of the yeast plasma membrane proteome to salt stress
Szopinska, Molecular & cellular proteomics : MCP 2011 - “...PM PM and MT P23291 P38250 P39004 P39003 P38695 P32467 P32466 P23585 P32465 P06775 P53154 P10823 P08539 P38631 Q08193 Q03655 P22146 P38196 P40088 Q12333 P32791...”
- Optimizing pentose utilization in yeast: the need for novel tools and approaches
Young, Biotechnology for biofuels 2010 - “...H2219 + Saccharomyces cerevisiae HXT2 P23585 pYX212 [ 66 ] H2219 + Saccharomyces cerevisiae HXT4 P32467 pYX212 [ 66 ] H2219 + Saccharomyces cerevisiae HXT7 P39004 pYX212 [ 66 ] H2219 + Saccharomyces cerevisiae HXT1 P32465 p4H7 [ 64 ] TMB3201 - Saccharomyces cerevisiae HXT3 P32466...”
- Computational identification of ubiquitylation sites from protein sequences.
Tung, BMC bioinformatics 2008 - “...P40087 410 0.86 P16603 165 0.91 P37303 283 0.87 P38075 10 0.86 P31539 626 0.91 P32467 38 0.87 Figure 10 The sequence logo of the 23 peptides of promising ubiquitylation sites with w = 21. (a) Information content and (b) Frequency plot. For further validating the...”
- Major facilitator superfamily
Pao, Microbiology and molecular biology reviews : MMBR 1998 - “...569 S59368 P13181 L21753 P49374 P32465 P23585 P32466 P32467 P38695 P39003 P39004 P40886 P43581 P40885 P39924 P42833 P47185 Z71687 P30605 X98622 P30606 S51081...”
- Snf1p-dependent Spt-Ada-Gcn5-acetyltransferase (SAGA) recruitment and chromatin remodeling activities on the HXT2 and HXT4 promoters.
van, The Journal of biological chemistry 2006 (PubMed)- GeneRIF: Snf1p-dependent Spt-Ada-Gcn5-acetyltransferase (SAGA) recruitment and chromatin remodeling activities on the HXT2 and HXT4 promoters.
XP_444861 hypothetical protein from Candida glabrata CBS 138
42% identity, 86% coverage
HXT3_YEAST / P32466 Low-affinity glucose transporter HXT3 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
NP_010632 hexose transporter HXT3 from Saccharomyces cerevisiae S288C
NP_010632, YDR345C Hxt3p from Saccharomyces cerevisiae
41% identity, 85% coverage
- function: Low-affinity glucose transporter
- Regulation of Hxt3 and Hxt7 turnover converges on the Vid30 complex and requires inactivation of the Ras/cAMP/PKA pathway in Saccharomyces cerevisiae.
Snowdon, PloS one 2012 - GeneRIF: turnover of both Hxt3 and Hxt7 is dependent on the essential E3 ubiquitin ligase, Rsp5, indicating that the role of the Vid30c might be indirect of Hxt ubiquitylation
- Advances in fungal sugar transporters: unlocking the potential of second-generation bioethanol production
Pereira, Applied microbiology and biotechnology 2025 - “...S. cerevisiae Reifenberger et al. ( 1995 ); Apel et al. ( 2016 ) HXT3 P32466 Glucose, fructose, and mannose S. cerevisiae Reifenberger et al. ( 1995 ); Apel et al. ( 2016 ) HXT4 P32467 Glucose, xylose, fructose and mannose S. cerevisiae Reifenberger et al....”
- Yeast α-arrestin Art2 is the key regulator of ubiquitylation-dependent endocytosis of plasma membrane vitamin B1 transporters
Savocco, PLoS biology 2019 - “...Q05998 THI7 0.14 P38631 FKS1 0.18 P04817 CAN1 0.19 Q01896 ENA2 0.24 P32791 FRE1 0.31 P32466 HXT3 0.35 P38085 TAT1 0.38 Q06689 INA1 0.41 P32465 HXT1 0.42 P39004 HXT7 0.44 P32467 HXT4 0.48 P38079 YRO2 0.55 P40088 FTR1 0.55 P05030 PMA1 0.58 Q12256 TPO4 0.58 P38993...”
- “...1.1 P32791 FRE1 5.4 4.2 4.7 3.1 3.6 2.4 2.5 1.9 2.8 1.9 2.8 1.7 P32466 HXT3 3.0 1.5 2.1 8.4 1.3 0.7 1.7 0.8 3.6 1.2 1.5 0.7 P38085 TAT1 2.4 1.8 2.2 1.1 1.6 1.6 1.4 1.4 0.7 1.2 1.2 1.6 Q06689 INA1 1.2...”
- Knockout of the Hmt1p Arginine Methyltransferase in Saccharomyces cerevisiae Leads to the Dysregulation of Phosphate-associated Genes and Processes
Chia, Molecular & cellular proteomics : MCP 2018 - “...YJR029W* Lac1p Dbp10p Hxt3p P25369 P35688 P47100 P28496 Q12389 P32466 a Uniprot accession number of protein. bAverage (mean) ratio of both A and B replicates....”
- Novel Citronellyl-Based Photoprobes Designed to Identify ER Proteins Interacting with Dolichyl Phosphate in Yeast and Mammalian Cells.
Rush, Current chemical biology 2015 - “...11 High-affinity hexose transporter HXT6 + + P39004 11 High-affinity hexose transporter HXT6 + + P32466 11 Low-affinity glucose transporter HXT3 + + P32467 11 Low-affinity glucose transporter HXT4 + + Q03516 11 Uncharacterized protein RSN1 + P53154 10 Glycerol uptake protein 1 GUP1 + P40441...”
- Functional survey for heterologous sugar transport proteins, using Saccharomyces cerevisiae as a host
Young, Applied and environmental microbiology 2011 - “...15, 36 P39924 HXT13 15, 36 P39004 HXT7 15, 36 P32466 HXT4 a EcoRI ClaI XmaI ClaI BamHI-HF ClaI XmaI ClaI P13181 GAL2 S. cerevisiae 3, 38 Introns, Synthesized...”
- Rapid response of the yeast plasma membrane proteome to salt stress
Szopinska, Molecular & cellular proteomics : MCP 2011 - “...and MT P23291 P38250 P39004 P39003 P38695 P32467 P32466 P23585 P32465 P06775 P53154 P10823 P08539 P38631 Q08193 Q03655 P22146 P38196 P40088 Q12333 P32791 P23900...”
- Optimizing pentose utilization in yeast: the need for novel tools and approaches
Young, Biotechnology for biofuels 2010 - “...H2219 + Saccharomyces cerevisiae HXT1 P32465 p4H7 [ 64 ] TMB3201 - Saccharomyces cerevisiae HXT3 P32466 p4H7 [ 64 ] TMB3201 - Saccharomyces cerevisiae HXT4 P32467 p4H7 [ 64 ] TMB3201 + Saccharomyces cerevisiae HXT5 P38695 p4H7 [ 64 ] TMB3201 + Saccharomyces cerevisiae HXT7 P39004...”
- Major facilitator superfamily
Pao, Microbiology and molecular biology reviews : MMBR 1998 - “...818 569 S59368 P13181 L21753 P49374 P32465 P23585 P32466 P32467 P38695 P39003 P39004 P40886 P43581 P40885 P39924 P42833 P47185 Z71687 P30605 X98622 P30606...”
- Functional analysis of a Phytophthora host-translocated effector using the yeast model system
Wilson, PeerJ 2021 - “...genes following PsAvh110 expression. LFC * Gene name Protein description & function (SGD) 1.5 HXT3 (YDR345C) Low affinity glucose transporter of the major facilitator superfamily; expression is induced in low and high glucose conditions 1.3 FRM2 (YCL026C-A) Type II nitroreductase; possible role in lipid signaling, oxidative...”
- “...* Term size Query size Intersecting genes GO:0005353 Fructose transmembrane transporter activity 2.43 15 4 YDR345C, YHR092C GO:0015578 Mannose transmembrane transporter activity 2.43 15 4 YDR345C, YHR092C TF:M00061_0 Factor: Mig1p; motif: KANWWWWATSYGGGGWA; match class: 0 2.83 74 6 YDR345C, YDR384C, YHR092C Notes: Gene set enrichment analysis...”
- Yeast Double Transporter Gene Deletion Library for Identification of Xenobiotic Carriers in Low or High Throughput
Almeida, mBio 2021 - “...YBR068C, YBR069C, YBR180W, YBR294W, YBR295W, YBR296C, YBR298C, YCL025C, YCR010C, YCR011C, YCR028C, YCR098C, YDL199C, YDR011W, YDR046C, YDR345C, YDR384C, YDR387C, YDR406W, YDR497C, YDR508C, YDR536W, YEL063C, YEL065W, YER056C, YER145C, YER166W, YFL011W, YFL040W, YFL050C, YFL055W, YGL077C, YGL114W, YGL255W, YGR055W, YGR121C, YGR138C, YGR217W, YGR224W, YGR260W, YGR281W, YGR289C, YHL016C, YHL040C, YHL047C, YHR092C,...”
- Transcriptional profiling reveals molecular basis and novel genetic targets for improved resistance to multiple fermentation inhibitors in Saccharomyces cerevisiae
Chen, Biotechnology for biofuels 2016 - “...YLR205C, YOL052C-A, YPL091W Transmembrane transport (GO:0055085) YAL053W, YBR008C, YBR054W , YCL025C, YCR021C , YDR011W, YDR135C, YDR345C , YER060W, YGL255W, YGR065C, YGR138C , YGR260W, YGR281W, YHL036W, YHR092C, YHR096C , YKL175W, YKR039W, YLL028W, YLR130C, YLR237W, YML116W, YOL119C, YOR153W, YOR306C, YOR328W, YPL036W, YPL058C, YPL274W YBR054W , YCL025C, YCR021C ,...”
- “..., YHR094C, YHR096C , YPL036W YBL075C, YBR008C, YBR054W , YBR069C, YCR021C , YDR011W, YDR046C, YDR135C, YDR345C , YDR497C, YER103W, YFL054C, YGL255W, YGR138C , YGR281W, YHR092C, YHR096C , YJR095W, YKL175W, YLL028W, YLR237W, YLR259C, YML116W, YOR153W, YOR328W, YPL058C, YPL274W, YPR138C, YPR156C Ion transport (GO: 0006811) YAL053W, YBR054W, YCL025C,...”
- Analysis of COPII Vesicles Indicates a Role for the Emp47-Ssp120 Complex in Transport of Cell Surface Glycoproteins
Margulis, Traffic (Copenhagen, Denmark) 2016 - “...Plasma membrane ferro-oxidoreductase, involved in iron uptake YMR307W Gas1 1 5 Plasma membrane GPI-anchored -glucanosyltransferase YDR345C Hxt3 4 7 Plasma membrane glucose transporter YDR245W Mnn10 0 3 Subunit of a Golgi mannosyltransferase complex YOR153W Pdr5 0 10 Plasma membrane ATP-binding cassette (ABC) transporter YGL008C Pma1 21...”
- Phylogenetic and Transcripts Profiling of Glucose Sensing Related Genes in Candida glabrata
Ng, Jundishapur journal of microbiology 2015 - “...YGL035C CAA96736 504 55.6 HXT1 YHR094C DAA06789 570 63.3 HXT2 YMR011W DAA09909 541 59.8 HXT3 YDR345C DAA12185 567 62.6 HXT4 YHR092C DAA06788 576 63.9 HXT5 YHR096C DAA06790 592 66.3 HXT6 YDR343C DAA12184 570 62.7 HXT7 YDR342C DAA12183 570 62.7 HXT8 YJL214W DAA08597 569 63.5 HXT9 YJL219W...”
- Transcription analysis of recombinant industrial and laboratory Saccharomyces cerevisiae strains reveals the molecular basis for fermentation of glucose and xylose
Matsushika, Microbial cell factories 2014 - “...6.13 11.97 9.20 Xylulokinase Hexose transporters YMR011W HXT2 41.40 26.68 2.20 2.38 High-affinity glucose transporter YDR345C HXT8 7.17 16.25 4.10 5.35 Protein of unknown function with similarity to hexose transporter family members Other transporters YCR098C GIT1 13.32 8.90 2.53 2.28 Plasma membrane permease, mediates uptake of...”
- “...2.32 4.56 Mitochondrial protein Hexose transporters YHR094C HXT1 -30.45 -21.51 -56.36 -46.31 Low-affinity glucose transporter YDR345C HXT3 -54.60 -20.87 -83.61 -32.66 Low-affinity glucose transporter YHR096C HXT5 22.20 48.69 22.78 44.86 Hexose transporter with moderate affinity for glucose Galactose metabolism YBR020W GAL1 19.10 32.47 3.71 5.48 Galactokinase...”
- Changes in cell morphology are coordinated with cell growth through the TORC1 pathway
Goranov, Current biology : CB 2013 - “..., S267, S288, S575 ; up S255 YPR185W Atg13 down down S454, S461, S652, S656 YDR345C Hxt3 down up S3 YJR001W Avt1 down NA YNL321W Vnx1 up up T26, S110, S121 YML035C Amd1 down down S105 YMR205C Pfk2 up up S41, S42, S170 YOL061W Prs5 up...”
- Identification of a novel deletion mutant strain in Saccharomyces cerevisiae that results in a microsatellite instability phenotype
Ji, BioDiscovery 2012 - “...10866.08 0.47 YBR301W uptag antisense 607.88 7201.59 0.52 YBR301W uptag sense 811.12 9768.15 0.52 DNF2 YDR345C downtag antisense 222.58 1070.08 0.52 YDR345C downtag sense 286.95 2700.63 0.52 YDR345C uptag antisense 243.56 2034.80 0.43 GYP8 YFL027C downtag sense 175.96 1300.91 0.52 YFL027C uptag antisense 780.84 5998.65 0.52...”
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TC 2.A.1.1.107 / P54854 Hexose transporter HXT15 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 3 papers)
NP_010036 hexose transporter HXT15 from Saccharomyces cerevisiae S288C
YDL245C Hxt15p from Saccharomyces cerevisiae
41% identity, 88% coverage
- substrates: Hexoses
- Optimizing pentose utilization in yeast: the need for novel tools and approaches
Young, Biotechnology for biofuels 2010 - “...TMB3201 - Saccharomyces cerevisiae HXT14 P42833 p4H7 [ 64 ] TMB3201 - Saccharomyces cerevisiae HXT15 P54854 p4H7 [ 64 ] TMB3201 - Saccharomyces cerevisiae GAL2 P13181 pHL125 [ 64 ] TMB3201 + Several previous studies have evaluated the capacity of selected transport proteins to uptake xylose...”
- Hxt13, Hxt15, Hxt16 and Hxt17 from Saccharomyces cerevisiae represent a novel type of polyol transporters.
Jordan, Scientific reports 2016 - GeneRIF: Show that Hxt13, Hxt15, Hxt16 and Hxt17 transport two major hexitols in nature, mannitol and sorbitol, with moderate affinities, by a facilitative mechanism.
- Improved Xylose Metabolism by a CYC8 Mutant of Saccharomyces cerevisiae
Nijland, Applied and environmental microbiology 2017 - “...Probe YMR011W YDR343C YDR342C YHR092C YHR096C YHR094C YJL214W YDL245C YJR158W YEL069C YFL011W YJL219W YOL156W YLR081W YNL318C Sum of all HXTs Sum of all genes...”
- Extensive Copy Number Variation in Fermentation-Related Genes Among Saccharomyces cerevisiae Wine Strains
Steenwyk, G3 (Bethesda, Md.) 2017 - “..., HXT9 / YJL219W , HXT11 / YOL156W , HXT13 / YEL069C , HXT15 / YDL245C , and HXT17 / YNR072W ), which is involved in sugar transport, that were among the 363 CN diverse genes (File S3 in File S1 ). Members of the HXT...”
- Phylogenetic and Transcripts Profiling of Glucose Sensing Related Genes in Candida glabrata
Ng, Jundishapur journal of microbiology 2015 - “...YOL156W DAA10630 567 62.7 HXT13 YEL069C DAA07586 564 62.7 HXT14 YNL318C CAA96250 540 61.0 HXT15 YDL245C DAA11622 567 62.9 HXT16 YJR158W DAA08942 567 62.9 HXT17 YNR072W DAA10613 564 62.8 3.2. Phylogenetic Analysis The multiple sequence alignment of selected amino acid sequences listed in Tables 1 and...”
- Transcriptome analysis of a respiratory Saccharomyces cerevisiae strain suggests the expression of its phenotype is glucose insensitive and predominantly controlled by Hap4, Cat8 and Mig1
Bonander, BMC genomics 2008 - “...6.8 c Glyoxylate cycle YCR005C CIT2 2.2 b Plasma membrane transport YEL069C HXT13 3.9 b,c YDL245C HXT15 3.2 c YBR298C MAL31 3.1 b Mitochondrial transport YNR002C ATO2 3.8 b YKL217W JEN1 10.3 b YPL134C ODC1 6.3 b Transcriptional regulation YDR516C EMI2 3.6 b,c YEL066W HPA3 2.2...”
- Resurrecting ancestral alcohol dehydrogenases from yeast
Thomson, Nature genetics 2005 - “...0.806b Pair not associated with any duplication block YDL245C gi|1431418 HXT15 Sugar transporter induced by low glucose, repressed by high glucose YNR072W...”
- “...induced by low glucose, repressed by high glucose YDL245C gi|1431418 HXT15 Sugar transporter Cytoplasmic chaperone induced 2-3 fold by heat shock Subfamily...”
- Improvement of galactose uptake in Saccharomyces cerevisiae through overexpression of phosphoglucomutase: example of transcript analysis as a tool in inverse metabolic engineering
Bro, Applied and environmental microbiology 2005 - “...YGL130W YOL143C YKL031W YLR286C YNL239W YGR022C YEL069C YDL245C YJR158W YNR072W YBR299W YGR292W YOL126C YFL011W YMR305C YKL216W YDR520C YGL035C YPL187W YMR199W...”
TC 2.A.1.1.110 / P39924 Hexose transporter HXT13 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 3 papers)
NP_010845 hexose transporter HXT13 from Saccharomyces cerevisiae S288C
YEL069C Hexose transporter, induced in the presence of non-fermentable carbon sources, induced by low levels of glucose, repressed by high levels of glucose from Saccharomyces cerevisiae
40% identity, 90% coverage
- substrates: Hexoses
- Hxt13, Hxt15, Hxt16 and Hxt17 from Saccharomyces cerevisiae represent a novel type of polyol transporters.
Jordan, Scientific reports 2016 - GeneRIF: Show that Hxt13, Hxt15, Hxt16 and Hxt17 transport two major hexitols in nature, mannitol and sorbitol, with moderate affinities, by a facilitative mechanism.
- Functional characterization of the hexose transporter Hxt13p: an efflux pump that mediates resistance to miltefosine in yeast.
Biswas, Fungal genetics and biology : FG & B 2013 (PubMed)- GeneRIF: Authors identified a new function of the hexose sugar transporter gene HXT13 when overexpressed in Saccharomyces cerevisiae, namely, in efflux of miltefosine and in mediating miltefosine resistance.
- Advances in fungal sugar transporters: unlocking the potential of second-generation bioethanol production
Pereira, Applied microbiology and biotechnology 2025 - “...Glucose, xylose, galactose, fructose, and mannose S. cerevisiae Young et al. ( 2011 ) HXT13 P39924 Glucose and mannose S. cerevisiae Young et al. ( 2011 ) Gal2 P13181 Glucose, xylose, L-arabinose, galactose, fructose, mannose, and ribose S. cerevisiae Hamacher et al. ( 2002 ); Becker...”
- Functional survey for heterologous sugar transport proteins, using Saccharomyces cerevisiae as a host
Young, Applied and environmental microbiology 2011 - “...here, including the restriction enzymes and primers used. 15, 36 P39924 HXT13 15, 36 P39004 HXT7 15, 36 P32466 HXT4 a EcoRI ClaI XmaI ClaI BamHI-HF ClaI XmaI...”
- Optimizing pentose utilization in yeast: the need for novel tools and approaches
Young, Biotechnology for biofuels 2010 - “...TMB3201 - Saccharomyces cerevisiae HXT11 P54862 p426MET25 [ 64 ] TMB3201 - Saccharomyces cerevisiae HXT13 P39924 p4H7 [ 64 ] TMB3201 - Saccharomyces cerevisiae HXT14 P42833 p4H7 [ 64 ] TMB3201 - Saccharomyces cerevisiae HXT15 P54854 p4H7 [ 64 ] TMB3201 - Saccharomyces cerevisiae GAL2 P13181...”
- Major facilitator superfamily
Pao, Microbiology and molecular biology reviews : MMBR 1998 - “...P32466 P32467 P38695 P39003 P39004 P40886 P43581 P40885 P39924 P42833 P47185 Z71687 P30605 X98622 P30606 S51081 P07921 P38156 P15685 P18631 X96876 Q10710 P38142...”
- Engineering cofactor supply and NADH-dependent D-galacturonic acid reductases for redox-balanced production of L-galactonate in Saccharomyces cerevisiae
Harth, Scientific reports 2020 - “...of expression cassettes and strains The Saccharomyces cerevisiae endogenous open reading frames (ORFs) of HXT13 (YEL069C) and SOR2 (YDL246C) were PCR amplified using the primer pairs SiHP011-SiHP012 ( HXT13 ) and SiHP015-SiHP016 ( SOR2 ). The open reading frame encoding YlSdr 22 ; UniProtKBQ6CEE9) was amplified...”
- Improved Xylose Metabolism by a CYC8 Mutant of Saccharomyces cerevisiae
Nijland, Applied and environmental microbiology 2017 - “...YDR343C YDR342C YHR092C YHR096C YHR094C YJL214W YDL245C YJR158W YEL069C YFL011W YJL219W YOL156W YLR081W YNL318C Sum of all HXTs Sum of all genes Gene HXT2...”
- Systematic Identification of Determinants for Single-Strand Annealing-Mediated Deletion Formation in Saccharomyces cerevisiae
Segura-Wang, G3 (Bethesda, Md.) 2017 - “...the homozygous yeast deletion collection. The insertion of the construct into the HXT13 gene ( YEL069C ) in chromosome V was verified by PCRs placing primers inside and outside of both sides of the construct. This locus has been used to test for chromosomal rearrangements in...”
- Extensive Copy Number Variation in Fermentation-Related Genes Among Saccharomyces cerevisiae Wine Strains
Steenwyk, G3 (Bethesda, Md.) 2017 - “..., HXT7 / YDR342C , HXT9 / YJL219W , HXT11 / YOL156W , HXT13 / YEL069C , HXT15 / YDL245C , and HXT17 / YNR072W ), which is involved in sugar transport, that were among the 363 CN diverse genes (File S3 in File S1 )....”
- Structural Motifs Critical for In Vivo Function and Stability of the RecQ-Mediated Genome Instability Protein Rmi1
Kennedy, PloS one 2015 - “..., his3200 , lys2-Bgl , hom3-10 , ade21 , ade8 , sgs1 :: HIS3 , YEL069C :: URA3 ,). The fragment was inserted into Xba I-digested pRS415 by gap-repair cloning using the non-homologous-endjoining deficient yeast strain KHSY2331 ( ura3-52 , leu21 , trp163 , his3200 ,...”
- Phylogenetic and Transcripts Profiling of Glucose Sensing Related Genes in Candida glabrata
Ng, Jundishapur journal of microbiology 2015 - “...YJL219W DAA08593 567 62.9 HXT10 YFL011W DAA12428 546 60.7 HXT11 YOL156W DAA10630 567 62.7 HXT13 YEL069C DAA07586 564 62.7 HXT14 YNL318C CAA96250 540 61.0 HXT15 YDL245C DAA11622 567 62.9 HXT16 YJR158W DAA08942 567 62.9 HXT17 YNR072W DAA10613 564 62.8 3.2. Phylogenetic Analysis The multiple sequence alignment...”
- Comparative transcriptomic analysis reveals similarities and dissimilarities in Saccharomyces cerevisiae wine strains response to nitrogen availability
Barbosa, PloS one 2015 - “...bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication HXT13 YEL069C 4.0 Hexose transporter; induced in the presence of non-fermentable carbon sources, induced by low levels of glucose, repressed by high levels of glucose; HXT13 has a paralog, HXT17, that arose...”
- Variation in gene duplicates with low synonymous divergence in Saccharomyces cerevisiae relative to Caenorhabditis elegans
Katju, Genome biology 2009 - “...0.0066 Complete YAR068W YHR214W-A 0.0000 Complete 11 YNR073C YEL070W 0.0482 0.0817 Complete XIVI/V 4,611 YNR072C YEL069C 0.1152 Complete 12 YAR033W YGL051W 0.0280 0.0973 Complete I/VII 6,461 YAR031W YGL053W 0.1667 Complete Columns 2 and 3 list the systematic names of the group of loci representing each paralogous...”
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YNR072W Hexose transporter, up-regulated in media containing raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose from Saccharomyces cerevisiae
NP_014470 hexose transporter HXT17 from Saccharomyces cerevisiae S288C
40% identity, 89% coverage
- Yeast Double Transporter Gene Deletion Library for Identification of Xenobiotic Carriers in Low or High Throughput
Almeida, mBio 2021 - “...YMR011W, YMR177W, YMR243C, YMR279C, YMR319C, YNL065W, YNL142W, YNL268W, YNL270C, YNL275W, YNL291C, YNL318C, YNR002C, YNR055C, YNR056C, YNR072W, YOL020W, YOL103W, YOL122C, YOL158C, YOR011W, YOR071C, YOR153W, YOR192C, YOR202W, YOR273C, YOR306C, YOR328W, YOR348C, YPL036W, YPL058C, YPL092W, YPL265W, YPL274W, YPR124W, YPR138C, YPR156C, YPR192W, YPR198W, and YPR201W ( 54 ). In the...”
- Improved Xylose Metabolism by a CYC8 Mutant of Saccharomyces cerevisiae
Nijland, Applied and environmental microbiology 2017 - “...right arm of chromosome XIV, including HXT17 (accession no. YNR072W). This is partially in contrast to the de novo genome sequencing of the progenitor strain...”
- “...genes reported to be present in this study, designated YNR072W (HXT17), YNR073C (DSF1), and YNR076W (PAU6) all have homologs elsewhere in the genome with 97,...”
- Crucial role of 4-deoxy-L-erythro-5-hexoseulose uronate reductase for alginate utilization revealed by adaptive evolution in engineered Saccharomyces cerevisiae
Matsuoka, Scientific reports 2017 - “...YNR073C (Man2)] that oxidizes mannitol to D-fructose, and the putative MFS transporter [YEL069C (Hxt13) or YNR072W (Hxt17)]. These genes were identified using microarray analysis of the S. cerevisiae that had been induced to grow efficiently in mannitol medium 16 through an unknown mechanism. EnquistNewman et al...”
- Extensive Copy Number Variation in Fermentation-Related Genes Among Saccharomyces cerevisiae Wine Strains
Steenwyk, G3 (Bethesda, Md.) 2017 - “...HXT11 / YOL156W , HXT13 / YEL069C , HXT15 / YDL245C , and HXT17 / YNR072W ), which is involved in sugar transport, that were among the 363 CN diverse genes (File S3 in File S1 ). Members of the HXT gene family were duplicated, deleted,...”
- Phylogenetic and Transcripts Profiling of Glucose Sensing Related Genes in Candida glabrata
Ng, Jundishapur journal of microbiology 2015 - “...YNL318C CAA96250 540 61.0 HXT15 YDL245C DAA11622 567 62.9 HXT16 YJR158W DAA08942 567 62.9 HXT17 YNR072W DAA10613 564 62.8 3.2. Phylogenetic Analysis The multiple sequence alignment of selected amino acid sequences listed in Tables 1 and 2 was calculated and generated through Clustal Omega program (...”
- Multi-targeted priming for genome-wide gene expression assays
Adomas, BMC genomics 2010 - “...3.13 YGR249W 1.66 0.01 5.80 0.00 4.79 8.20 YMR025W 1.51 0.00 3.96 0.15 2.10 1.57 YNR072W -1.24 0.05 -6.32 0.00 -2.34 -1.36 YFR034C -1.42 0.02 -1.25 0.10 -9.08 0.00 -6.41 0.08 1.30 1.24 YKR053C -5.37 0.00 -1.88 0.14 -2.16 0.00 1.15 0.51 -2.10 -2.05 YLR126C 1.54...”
- Resurrecting ancestral alcohol dehydrogenases from yeast
Thomson, Nature genetics 2005 - “...HXT16 Sugar transporter repressed by high glucose levels YNR072W gi|1302608 HXT17 Sugar transporter repressed by high glucose levels f2 1/4 0.806b Pair not...”
- “...induced by low glucose, repressed by high glucose YNR072W gi|1302608 f2 1/4 0.809b HXT17 Sugar transporter repressed by high glucose levels Sugar transporter...”
- Improvement of galactose uptake in Saccharomyces cerevisiae through overexpression of phosphoglucomutase: example of transcript analysis as a tool in inverse metabolic engineering
Bro, Applied and environmental microbiology 2005 - “...YKL031W YLR286C YNL239W YGR022C YEL069C YDL245C YJR158W YNR072W YBR299W YGR292W YOL126C YFL011W YMR305C YKL216W YDR520C YGL035C YPL187W YMR199W YJR159W YDL246C...”
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- Hxt13, Hxt15, Hxt16 and Hxt17 from Saccharomyces cerevisiae represent a novel type of polyol transporters.
Jordan, Scientific reports 2016 - GeneRIF: Show that Hxt13, Hxt15, Hxt16 and Hxt17 transport two major hexitols in nature, mannitol and sorbitol, with moderate affinities, by a facilitative mechanism.
P47185 Hexose transporter HXT16 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
NP_012692 hexose transporter HXT16 from Saccharomyces cerevisiae S288C
YJR158W Hxt16p from Saccharomyces cerevisiae
41% identity, 88% coverage
- Major facilitator superfamily
Pao, Microbiology and molecular biology reviews : MMBR 1998 - “...P38695 P39003 P39004 P40886 P43581 P40885 P39924 P42833 P47185 Z71687 P30605 X98622 P30606 S51081 P07921 P38156 P15685 P18631 X96876 Q10710 P38142 S58778 U32274...”
- Hxt13, Hxt15, Hxt16 and Hxt17 from Saccharomyces cerevisiae represent a novel type of polyol transporters.
Jordan, Scientific reports 2016 - GeneRIF: Show that Hxt13, Hxt15, Hxt16 and Hxt17 transport two major hexitols in nature, mannitol and sorbitol, with moderate affinities, by a facilitative mechanism.
- Improved Xylose Metabolism by a CYC8 Mutant of Saccharomyces cerevisiae
Nijland, Applied and environmental microbiology 2017 - “...YMR011W YDR343C YDR342C YHR092C YHR096C YHR094C YJL214W YDL245C YJR158W YEL069C YFL011W YJL219W YOL156W YLR081W YNL318C Sum of all HXTs Sum of all genes Gene...”
- Extensive Copy Number Variation in Fermentation-Related Genes Among Saccharomyces cerevisiae Wine Strains
Steenwyk, G3 (Bethesda, Md.) 2017 - “..., HXT5 / YHR096C , HXT8 / YJL214W , HXT10 / YFL011W , HXT16 / YJR158W , RGT2 / YDL138W , and SNF3 / YDL194W ) of the HXT gene family ( Figure 3 ). Interestingly, all remaining 10 members of the HXT gene family were...”
- Overexpression of a Water-Forming NADH Oxidase Improves the Metabolism and Stress Tolerance of Saccharomyces cerevisiae in Aerobic Fermentation
Shi, Frontiers in microbiology 2016 - “...sequences YFL039C ACT1 (reference gene) F: TGGATTCCGGTGATGGTGTT R: TGGCGTGAGGTAGAGAGAAACC L196579 noxE F: TCAAAAATGGCGCAATCAAG R: CCGCGTAAACATCTGGATCA YJR158W Hxt16 F: TTTGAGCAACGTGCGTATGG R: CGCCAATGGAACATCCTACA YDR343C HXT6 F: CGCTGCTATTGCAGAGCAAAC R: CGAGTGGGAGGCTGAGTCA YGR144W THI4 F: TTTGCCGTTTCTGACGTGATT R: GCGGCGGATAAACCTGAA YFL058W THI5 F: GGTTACTTCAAGGAGCAAGGTCTAGA R: CAGTGACATCGGAAGGATTGG YJR156C THI11 F: CAAGAAGGCAACCGACTACGT R: GAGGCTTGAAGTCGATGTATTCTTT YNL332W...”
- Phylogenetic and Transcripts Profiling of Glucose Sensing Related Genes in Candida glabrata
Ng, Jundishapur journal of microbiology 2015 - “...YEL069C DAA07586 564 62.7 HXT14 YNL318C CAA96250 540 61.0 HXT15 YDL245C DAA11622 567 62.9 HXT16 YJR158W DAA08942 567 62.9 HXT17 YNR072W DAA10613 564 62.8 3.2. Phylogenetic Analysis The multiple sequence alignment of selected amino acid sequences listed in Tables 1 and 2 was calculated and generated...”
- The reacquisition of biotin prototrophy in Saccharomyces cerevisiae involved horizontal gene transfer, gene duplication and gene clustering
Hall, Genetics 2007 - “...uptake? YBR018C (GAL7) YBR297W (MAL33) YGR288W (MAL13) YJR158W (HXT16) YBR019C (GAL10) YBR298C (MAL31) YGR289C (MAL11) YJR159W (SOR1) Biotin synthesis Biotin...”
- Resurrecting ancestral alcohol dehydrogenases from yeast
Thomson, Nature genetics 2005 - “...0.805b Pair not associated with any duplication block YJR158W gi|1015917 HXT16 Sugar transporter repressed by high glucose levels YNR072W gi|1302608 HXT17 Sugar...”
- “...levels Pair not associated with any duplication block YJR158W gi|1015917 HXT16 YEL069C gi|603249 HXT13 Sugar transporter induced by low glucose, repressed by...”
- Improvement of galactose uptake in Saccharomyces cerevisiae through overexpression of phosphoglucomutase: example of transcript analysis as a tool in inverse metabolic engineering
Bro, Applied and environmental microbiology 2005 - “...YOL143C YKL031W YLR286C YNL239W YGR022C YEL069C YDL245C YJR158W YNR072W YBR299W YGR292W YOL126C YFL011W YMR305C YKL216W YDR520C YGL035C YPL187W YMR199W YJR159W...”
- Molecular basis for anaerobic growth of Saccharomyces cerevisiae on xylose, investigated by global gene expression and metabolic flux analysis
Sonderegger, Applied and environmental microbiology 2004 - “...2.6 2.1 26 2.5 YBL015W YGL256W YJR078W YLR438W YAL062W YDR232W YJR158W YOL033W YNL073W YHR042W YGR087C YMR105C YOR321W 2.2 4.3 2.7 3.1 2.2 2.1 4.6 2.1 3.7 2.9 3...”
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B5RTM9 DEHA2D18876p from Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)
41% identity, 84% coverage
XP_042995203 uncharacterized protein from Ustilaginoidea virens
40% identity, 87% coverage
MGG_00040 high-affinity glucose transporter ght2 from Pyricularia oryzae 70-15
36% identity, 90% coverage
- Diterpene Biosynthesis in Rice Blast Fungus Magnaporthe
Shahi, Frontiers in fungal biology 2022 - “...oxidases and/or cytochromes P450 (MGG_00023, MGG_00024 & MGG_00031), dehydrogenase (MGG_00017); transcription factor (MGG_00032), and transporter (MGG_00040) ( Supplementary Figure 9 ). The biochemical characterization also showed conservation of product formation [pimara-8(9), 15-diene] and functionality of MoDiTPS2 among M. oryzae pathotypes ( Supplementary Figure 5 ). These...”
CH_124310 high-affinity glucose transporter ght2 from Magnaporthe grisea 70-15 (see paper)
36% identity, 90% coverage
FGSG_05042, XP_011323525 hypothetical protein from Fusarium graminearum PH-1
38% identity, 93% coverage
- FgFAD12 Regulates Vegetative Growth, Pathogenicity and Linoleic Acid Biosynthesis in Fusarium graminearum
Zhang, Journal of fungi (Basel, Switzerland) 2024 - “...RNA-seq data, decreased expression levels of genes in the Fgfad12 mutant, including FGSG_02279, FGSG_04745 and FGSG_05042, played roles in plant infection [ 49 , 69 , 70 ]. The reduced expression of these genes may also contribute to defects of Fgfad12 mutant in plant infection. In...”
- lncRsp1, a long noncoding RNA, influences Fgsp1 expression and sexual reproduction in Fusarium graminearum
Wang, Molecular plant pathology 2022 - “...RESULTS 2.1 Identification of lncRsp1 and Fgsp1 Based on the sequence analysis of the fulllength FGSG_05042 mRNA, the open reading frame (ORF) was determined to encode a protein of 534 amino acids (GenBank accession no. XP_011323525). NCBI domain analysis indicated that the protein contains a sugar...”
- “...frame (ORF) was determined to encode a protein of 534 amino acids (GenBank accession no. XP_011323525). NCBI domain analysis indicated that the protein contains a sugar transport domain and two MFS conserved domains. Therefore, FGSG_05042 was designated as Fgsp1 (Figure 1a ). Transmembrane domain prediction (...”
NCU05627 high affinity glucose transporter ght1 from Neurospora crassa OR74A
38% identity, 91% coverage
- The F-box protein gene exo-1 is a target for reverse engineering enzyme hypersecretion in filamentous fungi
Gabriel, Proceedings of the National Academy of Sciences of the United States of America 2021 (secret) - The regulatory and transcriptional landscape associated with carbon utilization in a filamentous fungus
Wu, Proceedings of the National Academy of Sciences of the United States of America 2020 - “...levels of growth on xylan ( 39 ), and pentose transporters xat-1 (NCU01132) and xyt-1 (NCU05627) ( 43 ) ( Fig. 5 ). CRE-1 binding peaks were not detected in the promoter of the major transcriptional regulator of xylan utilization, xlr-1 , although CRE-1 binding sites...”
- “...NCU06026 (quinate permease), NCU05897 ( sut-28 ), NCU10021 ( hgt-1 ), NCU00821 (sugar transporter), and NCU05627 (high-affinity glucose transporter ght-1 ). The remaining set of 21 genes included a number of carbon metabolic enzymes and 5 genes encoding proteins of unknown function ( Dataset S5 )....”
- Control of Development, Secondary Metabolism and Light-Dependent Carotenoid Biosynthesis by the Velvet Complex of Neurospora crassa
Bayram, Genetics 2019 - “...process DNA catabolic process NCU09685 4.133 -- NCU01808 NCU05627 4.047 4.0174 -- Transmembrane transport proteins that are known to form complexes in order to...”
- Alternative Oxidase Transcription Factors AOD2 and AOD5 of Neurospora crassa Control the Expression of Genes Involved in Energy Production and Metabolism
Qi, G3 (Bethesda, Md.) 2017 - “...in the absence of AOD2 ( Figure 9D ), while two (NCU04899, malate dehydrogenase and NCU05627, a glucose transporter) showed decreased expression in the absence of either AOD2 or AOD5 ( Figure 9E ). One gene (NCU02623, mitochondrial hypoxia response) shows only increased expression in the...”
- “...AOD5 + and Cm NCU04899 (malate dehydrogenase) 2+, 5+ N Na AOD5 + and Cm NCU05627 (high affinity glucose transporter 2+, 5+ N Na FN1/2+3/8+6/7 NCU05995 (ubiquitin) No effect Y Y FN3/8+4/5+6/7 NCU06211 (malate dehydrogenase) No effect Y Y FN1/2+3/8+6/7 NCU09144 (hypo) 5 N d Na...”
- A fungal transcription factor essential for starch degradation affects integration of carbon and nitrogen metabolism
Xiong, PLoS genetics 2017 - “...value less than 1e-20 identified 14 genes likely encoding transporters. Four of them, hgt-1 (NCU10021), NCU05627, NCU04963, and NCU04537 are annotated as sugar transporter genes ( Fig 2C ). hgt-1 shows high affinity glucose transport activity [ 19 ], while NCU05627 ( xyt-1 ) has xylose...”
- Transcriptional comparison of the filamentous fungus Neurospora crassa growing on three major monosaccharides D-glucose, D-xylose and L-arabinose
Li, Biotechnology for biofuels 2014 - “...here, including one glucose transporter GLT-1 (NCU01633) and two novel pentose transporters, XAT-1 (NCU01132), XYT-1 (NCU05627). One transcription factor associated with the regulation of hemicellulase genes, HCR-1 (NCU05064) was also characterized in the present study. Conclusions We conducted the first transcriptome analysis of Neurospora crassa grown...”
- “...149.95 5.65 NCU04963 High-affinity glucose transporter 4.91 128.69 402.90 NCU04537 Monosaccharide transporter 1.06 3.35 410.00 NCU05627 High affinity glucose transporter ght1 4.47 48.96 244.36 NCU00450 Sucrose transporter 28.78 52.91 23.15 NCU00801 MFS lactose permease 6.10 25.15 24.96 NCU00988 MFS quinate transporter 0.18 47.98 0.86 NCU01494 MFS...”
- Identification of the CRE-1 cellulolytic regulon in Neurospora crassa
Sun, PloS one 2011 - “...Five additional genes in this set encoded predicted sugar transporters, (NCU01633, NCU04537, NCU10021, NCU00821, and NCU05627), one encoded a nucleoside transporter (NCU08148), several genes had annotation suggesting a role in alternative carbon source utilization (e.g. pyruvic acid), and 26 genes encoded putative or hypothetical proteins. No...”
- Systems biology of the qa gene cluster in Neurospora crassa
Tang, PloS one 2011 - “...is also the more gradual response of the qa-y and a putative carbohydrate metabolism gene (NCU05627). The pronounced delay in kinetic response to QA can be seen in the transcription factor (NCU03643) and a gene (NCU09873) encoding a phosphoenolpyruvate carboxykinase involved in glycolysis/glucanogenesis [51] . The...”
- More
P40441 Putative hexose transporter 12 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
41% identity, 83% coverage
KLMA_50362 hexose transporter from Kluyveromyces marxianus DMKU3-1042
44% identity, 74% coverage
H6S33_000450 uncharacterized protein from Morchella sextelata
37% identity, 91% coverage
- Comparative Transcriptome Profiles of the Response of Mycelia of the Genus Morchella to Temperature Stress: An Examination of Potential Resistance Mechanisms
Yue, Journal of fungi (Basel, Switzerland) 2024 - “...module II were related to the catabolic process of glucose with putative MFS monosaccharide transporter (H6S33_000450), alpha/beta-hydrolase (H6S33_000895), glycoside hydrolase/deacetylase (H6S33_005331, H6S33_012593), and glyceraldehyde 3-phosphate dehydrogenase (H6S33_011274). Moreover, two cytochrome-related genes, H6S33_008973 and H6S33_007572, were identified. These results indicated that high culture temperatures accelerated the oxidative...”
- “...carbon and nitrogen sources to meet metabolic requirements [ 45 ]. The MFS monosaccharide transporter H6S33_000450 was identified among the module I genes, which is consistent with the findings of previous reports showing that major facilitator superfamily (MFS) proteins are involved mainly in energy metabolism [...”
CNG01480 hexose transport-related protein from Cryptococcus neoformans var. neoformans JEC21
33% identity, 97% coverage
- Comprehensive genome-scale metabolic model of the human pathogen Cryptococcus neoformans: A platform for understanding pathogen metabolism and identifying new drug targets
Tezcan, Frontiers in bioinformatics 2023 - “...2 CNI03590 Phosphoenolpyruvate carboxykinase PPCK CNK00280 Phosphoglycerate mutase PGM 3 CNN00260 Sugar transporter GLCt1, GALt2 CNG01480 Hexose transport-related protein GLCt2, FRUt2, MANt2 4 CNJ01880 Ammonium transporter NH4t CNA02250 NH4t 5 CNF04620 Aminotran containing protein AATA3, PHETA1 CNB03180 AATA3, PHETA1 6 CNL06640 Phospho-2-dehydro-3-deoxyheptonate aldolase DDPA, DDPAm CND05120...”
- ALL2, a Homologue of ALL1, Has a Distinct Role in Regulating pH Homeostasis in the Pathogen Cryptococcus neoformans
Jain, Infection and immunity 2016 - “...CNC04510 CNG04630 CNJ01450 CNE01880 CNF01220 CNF00350 CNG01480 CNC03220 CNI03490 CNC01890 CNE05340 Sugar transporter Folic acid metabolism Sugar transporter...”
CNAG_03438 hexose transporter from Cryptococcus neoformans var. grubii H99
33% identity, 97% coverage
- Comparative Ecology of Capsular Exophiala Species Causing Disseminated Infection in Humans
Song, Frontiers in microbiology 2017 - “...et al., 2002 PV08_06497T0 HMPREF1120_06227T0 CNAG_03322 UXS1 Xylosolation defect Moyrand et al., 2002 N/A N/A CNAG_03438 HXT1 Hyper Chikamori and Fukushima, 2005 N/A N/A CNAG_03582 RIM20 Hypo Meara et al., 2010b PV08_05544T0 HMPREF1120_02658T0 CNAG_03670 IRE1 Hypo Cheon et al., 2011 PV08_04820T0 HMPREF1120_00610T0 CNAG_03818 SSK1 Hyper Bahn...”
- The glucose sensor-like protein Hxs1 is a high-affinity glucose transporter and required for virulence in Cryptococcus neoformans
Liu, PloS one 2013 - “...and investigated their expressions under different glucose conditions. Our qRT-PCR results showed that two gene (CNAG_03438, HXT1; CNAG_04920, HXT5 ) were induced by both low and high glucose concentrations, with a significantly higher induction in HXT1 . Meanwhile, HXT2 (CNAG_06290) was induced only by the high...”
- The transcriptional response of Cryptococcus neoformans to ingestion by Acanthamoeba castellanii and macrophages provides insights into the evolutionary adaptation to the mammalian host
Derengowski, Eukaryotic cell 2013 - “...CNAG_05929 CNAG_02288 CNAG_07367 CNAG_04795 CNAG_07387 CNAG_03438 Sugar transporter Sugar transporter bodown198 Sugar transporter Glucose transporter...”
- The Cryptococcus neoformans capsule: a sword and a shield
O'Meara, Clinical microbiology reviews 2012 - “...Cpl1 Capsule-associated protein Uge1 CNAG_03158 CNAG_03322 CNAG_03438 Cmt1 Uxs1 Hxt1 CNAG_03644 Cas3 CNAG_03695 Cas41 CNAG_03735 Cap4 CNAG_04312 CNAG_04320...”
- Toward an integrated model of capsule regulation in Cryptococcus neoformans
Haynes, PLoS pathogens 2011 - “...0.81 0.56 Capsule CNAG_03644 CAS3 Cas3 4.21 7.69 CNAG_05264 NSTA YJL216C alpha-amylase AmyA 2.06 1.97 CNAG_03438 HXT1 HXT2 hexose transporter 1.15 1.35 CNAG_02797 CPL1 pria protein 1.01 0.65 CNAG_07937 CAS1 O-acetyltransferase 0.60 0.41 CNAG_04312 MAN1 PMI40 mannose-6-phosphate isomerase 0.57 0.28 CNAG_07554 CAP10 capsule associated protein 0.43...”
TC 2.A.1.1.68 / A3M0N3 The Glucose Transporter/Sensor Rgt2 from Pichia stipitis (see paper)
XP_001386588 glucose transporter/sensor from Scheffersomyces stipitis CBS 6054
37% identity, 89% coverage
- substrates: glucose
- Genetic basis of the highly efficient yeast Kluyveromyces marxianus: complete genome sequence and transcriptome analyses
Lertwattanasakul, Biotechnology for biofuels 2015 - “...Ps_XUT1, XP_001385583; Ps_XUT2, XP_001387242; Ps_XUT3, XP_001387138; Ps_XUT4, XP_001386715; Ps_XUT5, XP_001385962; Ps_XUT6, XP_001386589; Ps_XUT7, XP_001387067; Ps_RGT2, XP_001386588; Ps_SLT1, XP_001383774; Kl_KHT1/RAG1, XP_453656; Kl_KHT2, GN107317; Kl_KHT3, XP_454897; Kl_FRT1, XP_454356; Kl_HGT1, XP_451484; Kl_HXT1, XP_455078; Kl_HXT14, XP_454897; Kl_HXT2, XP_453960; Kl_HXT3, XP_453088; Sc_HXT4/LGT1, NP_011960; Kl_STL1, XP_456249; Kl_RAG4, XP_455315; Kl_LAC12, XP_452193; Ca_HXT6, XP_719472....”
HGT12 potential sugar sensor or transporter from Candida albicans (see 4 papers)
XP_720385 Hgt12p from Candida albicans SC5314
Q8J2J7 Putative glucose sensor protein from Candida albicans
35% identity, 95% coverage
- CharProtDB CGD description: glucose, fructose, mannose transporter; major facilitator superfamily; role in macrophage-induced hyphal growth; detected at germ tube plasma membrane by mass spectrometry; Snf3p-induced; 12 probable transmembrane segments
- The Candida albicans gene HGT12 (orf19.7094) encodes a hexose transporter.
Luo, FEMS immunology and medical microbiology 2007 (PubMed)- GeneRIF: The HGT12 gene encodes a fructose, glucose, and mannose transporter.
- GeneRIF: The C. albicans gene HGT12, which is specifically expressed during macrophage infection, encodes a protein that transports fructose, glucose and mannose.
- Do mitochondria use efflux pumps to protect their ribosomes from antibiotics?
Islam, Microbiology (Reading, England) 2023 - “...ABC O42765, 7.8E^6 A0A1P8ATY7, 6.7E^12 Q8WW24, 1.4E^14 [ 79, 112 ] HXT13, NCU01633 Q1K4S3 MFS Q8J2J7, 2.1E^85 P23586, 1.2E^52 P11168, 2.6E^48 [ 79 ] NCU04809 Q756M6 MFS T2AWG3, 0.0014 Q8GYF4, 1.4E^24 B3KT41, 0.0022 [ 79 ] NCU09551 Q7S2B0 MFS G1UAY0, 2.3E^6 Q56ZZ7, 2.3E^7 Q8NBP5, 8.4E^9 [...”
TC 2.A.1.1.51 / Q2MEV7 Glucose/xylose: H+ symporter, Gsx1 from Candida intermedia (see paper)
GXS1 / CAI44932.1 glucose/xylose symporter 1 from [Candida] intermedia (see paper)
37% identity, 92% coverage
- substrates: H+, Xylose, glucose
- Advances in fungal sugar transporters: unlocking the potential of second-generation bioethanol production.
Pereira, Applied microbiology and biotechnology 2025 - “...C. intermedia Leandro et al. ( 2006 ); Young et al. ( 2011 ) GXS1 Q2MEV7 Glucose, xylose, galactose, fructose, mannose, and ribose C. intermedia Leandro et al. ( 2006 ); Young et al. ( 2011 ) XylHP Q64L87 Glucose, xylose, galactose, fructose, and mannose D....”
- Optimizing pentose utilization in yeast: the need for novel tools and approaches.
Young, Biotechnology for biofuels 2010 - “...TMB3201 - Candida intermedia Gxf1 Q2MDH1 YEplac195 [ 72 ] TMB3201 + Candida intermedia Gxs1 Q2MEV7 YEplac195 [ 72 ] TMB3201 + Chlorella kessleri Hup1 P15686 p4H7 [ 64 ] TMB3201 - Escherichia coli XylE P0AGF4 p4H7 [ 64 ] TMB3201 - Pichia stipitis SUT1 O94155...”
Q6BTD8 DEHA2D01474p from Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)
36% identity, 94% coverage
CNN00260 sugar transporter from Cryptococcus neoformans var. neoformans JEC21
33% identity, 96% coverage
Q6CCJ1 YALI0C08943p from Yarrowia lipolytica (strain CLIB 122 / E 150)
35% identity, 93% coverage
XP_042998199 uncharacterized protein from Ustilaginoidea virens
36% identity, 88% coverage
AFUA_2G14590, Afu2g14590 MFS monosaccharide transporter, putative from Aspergillus fumigatus Af293
34% identity, 94% coverage
- Broad-spectrum antimicrobial activities of a food fermentate of Aspergillus oryzae
Choi, Microbiology spectrum 2024 - “...ABC multidrug transporter 1.38 AFUA_5G11980 MFS efflux transporter 1.33 AFUA_6G00440 Putative cation diffusion facilitator 1.27 AFUA_2G14590 Putative MFS monosaccharide transporter 1.16 AFUA_8G06760 Putative MFS transporter 1.09 DAN repair AFUA_3G12280 Translin Putative recombination hotspot-binding protein 1.43 AFUA_1G07000 Rad26 Putative DNA repair protein 1.13 AFUA_2G16260 Ase1 Putative microtubule-associated...”
- Expression profile analysis reveals that Aspergillus fumigatus but not Aspergillus niger makes type II epithelial lung cells less immunological alert
Escobar, BMC genomics 2018 - “...Aspni7|1,098,546 8.69 Up Afu1g15260 6.04 Up Aspni7|1,182,543 14.4 Up Afu1g15300 3.02 Up Aspni7|1,206,763 87.12 Up Afu2g14590 7.36 Up Aspni7|1,143,598 3.65 Up Afu2g15650 23.66 Up Aspni7|1,104,467 21.14 Up Afu3g07810 4.36 Up Aspni7|1,136,064 3.23 Up Afu4g03390 6.27 Up Aspni7|1,161,552 14.33 Up Afu4g12590 15.18 Up Aspni7|1,117,353 48.25 Up Afu4g12920...”
- Evolutionary Analysis of Sequence Divergence and Diversity of Duplicate Genes in Aspergillus fumigatus
Yang, Evolutionary bioinformatics online 2012 - “...2.24 [2.13, 1.11] Afu6g11610 2.61 [2.07, 0.63] Afu1g00310 2.26 [1.61, 0.07] Afu3g07160 2.51 [2.18, 0.85] Afu2g14590 2.26 [2.17, 1.13] Afu2g02110 2.53 [1.87, 0.19] Afu7g06400 2.29 [2.16, 1.08] Afu8g05910 2.38 [2.08, 0.87] Afu3g03080 2.29 [2.12, 1.05] Afu6g14540 2.57 [2.12, 0.76] Afu1g11560 2.34 [2.15, 1.04] Afu3g14820 4.04 [1.80,...”
- Dual organism transcriptomics of airway epithelial cells interacting with conidia of Aspergillus fumigatus
Oosthuizen, PloS one 2011 - “...PkaR 2.62E-02 1.76 Afu4g12950 PX domain protein 2.74E-02 2.11 Afu2g11900 pyruvate dehydrogenase kinase 2.87E-02 2.45 Afu2g14590 MFS monosaccharide transporter, putative 3.05E-02 1.98 Afu3g00900 alpha-amylase AmyA 3.80E-02 1.62 Afu6g03730 prpd protein 4.08E-02 1.58 A general concordance was found between our microarray data and RT-qPCR data ( Figure...”
XP_006966515 uncharacterized protein from Trichoderma reesei QM6a
G0RN44 Predicted protein from Hypocrea jecorina (strain QM6a)
35% identity, 92% coverage
- Key amino acid residues govern the substrate selectivity of the transporter Xltr1p from <i>Trichoderma reesei</i> for glucose, mannose, and galactose
Ma, Engineering microbiology 2024 - “...unless otherwise noted. 2.2 Gene constructs and site-directed mutagenesis The gene encoding Xltr1p (GenBank ID: XP_006966515) was amplified from T. reesei QM6a (ATCC 13631) using primers harboring homologous arms and ligated into the pJFE3 vector to obtain the recombinant plasmid pJFE3-Xltr1p. Mutants were generated using a...”
- “...reesei , XP_006967659.1; Tr Str3 from Trichoderma reesei , EGR49690.1; Xltr1p from Trichoderma reesei , XP_006966515.1; Sc GAL2 from saccharomyces cerevisiae , NP_013182.1). (B) Prediction of the evolutionary conservation of Xltr1p amino acid sequences using Consurf ( https://predictprotein.org/ ). Fig. 1 Fig. 2 Substrateprotein docking analyses....”
- Advances in fungal sugar transporters: unlocking the potential of second-generation bioethanol production.
Pereira, Applied microbiology and biotechnology 2025 - “...) Xlt1 A0A024SJF7 Xylose and L-arabinose T. reesei Havukainen et al. ( 2021a ) Xltr1 G0RN44 Glucose, mannose, fructose, and xylose T. reesei Jiang et al. ( 2020 ) Mfs A0A024S949 Cellobiose, lactose, galactose, and mannose T. reesei Wang et al. ( 2022a ) Gst A0A024S5D9...”
XP_454897 hypothetical protein from Kluyveromyces lactis NRRL Y-1140
35% identity, 87% coverage
- Genetic basis of the highly efficient yeast Kluyveromyces marxianus: complete genome sequence and transcriptome analyses
Lertwattanasakul, Biotechnology for biofuels 2015 - “...Ps_XUT5, XP_001385962; Ps_XUT6, XP_001386589; Ps_XUT7, XP_001387067; Ps_RGT2, XP_001386588; Ps_SLT1, XP_001383774; Kl_KHT1/RAG1, XP_453656; Kl_KHT2, GN107317; Kl_KHT3, XP_454897; Kl_FRT1, XP_454356; Kl_HGT1, XP_451484; Kl_HXT1, XP_455078; Kl_HXT14, XP_454897; Kl_HXT2, XP_453960; Kl_HXT3, XP_453088; Sc_HXT4/LGT1, NP_011960; Kl_STL1, XP_456249; Kl_RAG4, XP_455315; Kl_LAC12, XP_452193; Ca_HXT6, XP_719472. Genes for the initial catabolism of xylose, PPP,...”
NCU08180 high-affinity glucose transporter from Neurospora crassa OR74A
35% identity, 79% coverage
NCU02582, XP_965713 RCO3 from Neurospora crassa OR74A
34% identity, 82% coverage
- Revisiting 2-Deoxyglucose Resistance in Neurospora crassa: Insights into Transcriptional Regulation of Hexose Transporters, Sugar Metabolism and Possible Modulation by Mating Type
Pandey, 2023 - Deletion of the col-26 Transcription Factor Gene and a Point Mutation in the exo-1 F-Box Protein Gene Confer Sorbose Resistance in Neurospora crassa
Hirai, Journal of fungi (Basel, Switzerland) 2022 - “...A NCU07788 mat A ; col -26:: Hyg r 11031 FGSC a sor -4 a NCU02582 mat a ; sor -4:: Hyg r 17928 FGSC a sor -4(DS(r)) A NCU02582 mat A ; sor -4(DS(r)) 1741 FGSC a hxk -2 a NCU00575 mat a ; hxk...”
- Glucose sensing and light regulation: A mutation in the glucose sensor RCO-3 modifies photoadaptation in Neurospora crassa.
Olmedo, Fungal biology 2018 (PubMed)- GeneRIF: The mutation in rco-3 modifies the transcriptional response to light of several genes and leads to changes in photoadaptation without significantly changing the amount and regulation of WC-1.
- Transcriptional comparison of the filamentous fungus Neurospora crassa growing on three major monosaccharides D-glucose, D-xylose and L-arabinose
Li, Biotechnology for biofuels 2014 - “...sugar transporters: NCU00821 ( Xyp29 , D-xylose-specific transporter), NCU08114 ( cdt-2 , cellodextrin transport) and NCU02582 ( rco-3 , glucose transporter) [ 9 , 31 , 32 ], and 10 putative sugar transporters, which will be discussed later. In addition, 50 of 300 CAZy genes were...”
- “...High affinity glucose transporter 23.68 38.96 16.02 NCU01868 MFS maltose permease malp 0.41 2.42 0.54 NCU02582 Rco3 9.65 42.90 12.30 NCU04310 Sugar transporter 9.68 26.59 12.88 NCU05350 Sugar transporter 0.37 10.25 0.55 NCU05585 MFS quinate transporter 1.01 47.89 1.52 NCU06026 Quinate permease 5.99 37.83 13.25 NCU06358...”
- Deciphering transcriptional regulatory mechanisms associated with hemicellulose degradation in Neurospora crassa
Sun, Eukaryotic cell 2012 - “...transporter genes (NCU00988, NCU01132, NCU02188, NCU02238, NCU02582, NCU05853, NCU06138, NCU06305, NCU06358, NCU08114, and NCU09027). In addition, 6...”
PDIP_03090 MFS monosaccharide transporter, putative from Penicillium digitatum
33% identity, 94% coverage
METBIDRAFT_79721 general substrate transporter from Metschnikowia bicuspidata var. bicuspidata NRRL YB-4993
37% identity, 86% coverage
- Potential Strategies Applied by <i>Metschnikowia bicuspidata</i> to Survive the Immunity of Its Crustacean Hosts
Zhang, Pathogens (Basel, Switzerland) 2025 - “...acid transportation ( METBIDRAFT_70890 and METBIDRAFT_75879 ), transportation by major facilitator-type transporters ( METBIDRAFT_76181 and METBIDRAFT_79721 ), and others ( Table 1 ). Interestingly, the expression of METBIDRAFT_33390 , whose product is a transcriptional regulator homologous with the one mediating cell adherence in C. albicans ,...”
- “...Multidrug resistance protein 1 METBIDRAFT_76577 2.92 0.000122001 Sugar (and other) transporter High-affinity glucose transporter HXT2 METBIDRAFT_79721 2.80 0.000389761 Sugar (and other) transporter Major facilitator-type transporter ecdD METBIDRAFT_79129 2.78 0.000217936 GPR1/FUN34/yaaH family Accumulation of dyads protein 2 METBIDRAFT_33390 2.73 0.000286938 Zinc finger, C2H2 type Transcriptional regulator of...”
CTRG_06249 hypothetical protein from Candida tropicalis MYA-3404
33% identity, 93% coverage
K9H0P1 MFS monosaccharide transporter, putative from Penicillium digitatum (strain Pd1 / CECT 20795)
35% identity, 86% coverage
SS1G_05456 hypothetical protein from Sclerotinia sclerotiorum 1980 UF-70
34% identity, 95% coverage
XP_455315 hypothetical protein from Kluyveromyces lactis NRRL Y-1140
32% identity, 67% coverage
- Genetic basis of the highly efficient yeast Kluyveromyces marxianus: complete genome sequence and transcriptome analyses
Lertwattanasakul, Biotechnology for biofuels 2015 - “...Kl_HGT1, XP_451484; Kl_HXT1, XP_455078; Kl_HXT14, XP_454897; Kl_HXT2, XP_453960; Kl_HXT3, XP_453088; Sc_HXT4/LGT1, NP_011960; Kl_STL1, XP_456249; Kl_RAG4, XP_455315; Kl_LAC12, XP_452193; Ca_HXT6, XP_719472. Genes for the initial catabolism of xylose, PPP, the conversion of PEP to ethanol, the mitochondrial conversion of acetaldehyde to acetyl-CoA and TCA cycle were relatively...”
VDAG_00974 low-affinity glucose transporter HXT3 from Verticillium dahliae VdLs.17
35% identity, 84% coverage
An15g03940, XP_001396930 uncharacterized protein from Aspergillus niger
34% identity, 96% coverage
- Advances in fungal sugar transporters: unlocking the potential of second-generation bioethanol production
Pereira, Applied microbiology and biotechnology 2025 - “...XP_025453682 Glucose, galactose, mannose, and sucrose A. niger Sloothaak et al. ( 2015 ) MstH XP_001396930 Glucose, fructose, galactose, mannose, and sucrose A. niger Sloothaak et al. ( 2015 ) XltA XP_026623817 Glucose, xylose, galactose, and mannose A. niger Sloothaak et al. ( 2016b ) MstC/HxtB...”
- ERV14 receptor impacts mycelial growth via its interactions with cell wall synthase and transporters in Aspergillus niger
Zheng, Frontiers in microbiology 2023 - “...screening. Family Protein accession Gene ID Description MFS family CAK47634 An02g03540 Fructose transmembrane transporter CAK97262 An15g03940 Monosaccharide transporter CAK37108 An01g07860 Sulfate transmembrane transporter ABC family CAK43073 An17g01770 ATPase-coupled transmembrane transporter F-ATPase family CAK37765 An02g08020 H + -transporting ATPase lipid-binding protein P-ATPase family CAK41966 An14g02290 ATPase-coupled cation...”
- Evaluation of Aspergillus niger Six Constitutive Strong Promoters by Fluorescent-Auxotrophic Selection Coupled with Flow Cytometry: A Case for Citric Acid Production
Lu, Journal of fungi (Basel, Switzerland) 2022 - “...glucose uptake, and glycolysis, such as amyA (An12g06930), glaA (An03g06550), mstC (An02g03540), mstG (An05g01290), mstH (An15g03940), pfkB (An07g02100), and ppcA (An11g02550) ( Table 2 ). As to intracellular citrate transportation, mitochondrial citrate/malate carrier protein CtpA (An11g11230) was also synergistically upregulated ( Table 2 ). Meanwhile, with...”
- “...affinity glucose transporter 1.25 1.58 1.26 An05g01290 mstG High affinity glucose transporter 1.25 1.39 1.11 An15g03940 mstH High affinity glucose transporter 2.73 5.75 2.11 An04g06910 amyR Transcription factor 2.35 2.59 1.10 An08g02260 pgkA Phosphoglycerate kinase 1.32 1.37 1.04 An11g02550 ppcA Phosphoenolpyruvate carboxykinase 2.57 4.30 1.67 An07g02100...”
- In Silico Analysis of Putative Sugar Transporter Genes in Aspergillus niger Using Phylogeny and Comparative Transcriptomics
Peng, Frontiers in microbiology 2018 - “...sensors Rgt2 and Snf3 ( Gancedo, 2008 ), which cluster together with A. niger mstH (An15g03940). This gene is a homolog of A. nidulans HxtB ( Dos Reis et al., 2013 ), which has been suggested to be a low affinity glucose transporter that is involved...”
- The amyR-deletion strain of Aspergillus niger CICC2462 is a suitable host strain to express secreted protein with a low background
Zhang, Microbial cell factories 2016 - “...110.6 3.27 5.08 2.14E285 Serine-type Carboxypeptidase F An08g04490 215.81 17.92 3.59 0 Endoprotease Sugar transporter An15g03940 1891.82 158.73 3.58 0 Glucose transporter rco-3 An12g07450 372.55 6.95 5.74 0 Sugar transporter An01g00850 117.57 2.28 5.69 0 Sugar transporter An02g00590 258.7 14.23 4.18 0 Sugar transporter Table6 Positions...”
- “...None None None None aspartic endopeptidase (AP1) An07g08030 None None None None Serine-type carboxypeptidase F An15g03940 554 to 567 None None None Glucose transporter rco-3 An12g07450 None None 702 to 715 885 to 898 867 to 880 Sugar transporter An01g00850 None None 758 to 771 None...”
- Metabolic activity in dormant conidia of Aspergillus niger and developmental changes during conidial outgrowth
Novodvorska, Fungal genetics and biology : FG & B 2016 - “...encoding putative glucose/hexose transporters ( Pel et al., 2007 ) transcription of 5 genes (An02g03540, An15g03940, An05g01290, An16g08940, An02g01270) was highly upregulated at T1. The most upregulated was the homolog of A. nidulans mstE , (An02g03540) encoding a low affinity glucose transporter. Transcription of mstA encoding...”
- “...An01g09290 85.1 17.6 Neutral trehalase, treB a An02g03540 15.8 489.9 Low affinity glucose transporter, mstE An15g03940 4.0 336.7 Monosaccharide transporter An05g01290 2.8 324.2 Monosaccharide transporter An16g08940 5.1 118.8 Monosaccharide transporter An02g01270 1.6 25.8 Monosaccharide transporter An12g07450 1.6 9.5 High affinity sugar/H+symporter, mstA An02g01560 0.1 1.4 GPCR...”
- Genome-wide expression analysis upon constitutive activation of the HacA bZIP transcription factor in Aspergillus niger reveals a coordinated cellular response to counteract ER stress
Carvalho, BMC genomics 2012 - “...uptake An02g03540 mstC strong similarity to hexose transport protein HXT3 S. cerevisiae 2 2 2 An15g03940 strong similarity to monosaccharide transporter Mst-1 A. muscaria 2.5 2 1.7 An09g04810 strong similarity to high affinity glucose transporter HGT1 - K. lactis 5 10 10 An11g01100 strong similarity to...”
- Identification of InuR, a new Zn(II)2Cys6 transcriptional activator involved in the regulation of inulinolytic genes in Aspergillus niger
Yuan, Molecular genetics and genomics : MGG 2008 - “...dependent on InuR. Genome-wide expression analysis revealed, three additional putative sugar transporters encoding genes (An15g04060, An15g03940 and An17g01710), which were strongly induced by sucrose in an InuR dependent way. In silico analysis of the promoter sequences of strongly InuR regulated genes suggests that InuR might bind...”
- “...the seven sucrose induced InuR dependant genes: An12g08280 (InuE), An11g03200 (InuA), An08g11070 (SucA), An15g04060, An15g00310, An15g03940, and An17g01710 were obtained from the CBS513.88 strain. The 1.0kb promoter regions were analyzed on both strands using DNA Analyzer module of Phylosopher 6.5.1 (Genedata A.G., Basel, Switzerland) using the...”
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SNF3_YEAST / P10870 Low glucose sensor SNF3; High-affinity glucose receptor SNF3; High-affinity transporter-like sensor SNF3; Sucrose nonfermenting protein 3 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 5 papers)
TC 2.A.1.1.17 / P10870 Glucose transporter from Saccharomyces cerevisiae (see 7 papers)
NP_010087 glucose sensor from Saccharomyces cerevisiae S288C
NP_010087, YDL194W Plasma membrane glucose sensor that regulates glucose transport; has 12 predicted transmembrane segments; long cytoplasmic C-terminal tail is required for low glucose induction of hexose transporter genes HXT2 and HXT4 from Saccharomyces cerevisiae
33% identity, 59% coverage
- function: High-affinity low glucose sensor that is part of the sensor/receptor-repressor (SSR) glucose-signaling pathway, which detects extracellular glucose and induces expression of glucose transporters that bring glucose into the cell (PubMed:8901598, PubMed:9564039). The transporter-like sensor generates an intracellular signal in the presence of low levels of glucose to promote low glucose- induced expression of HXT2 (PubMed:9564039). Binding of glucose to the SNF3 transmembrane domain activates a downstream signaling cascade, leading to phosphorylation of the RGT1 corepressors MTH1 and STD1, targeting them for SCF(Grr1)-dependent ubiquitination and degradation. Depletion of the corepressors robs RGT1 of its ability to repress expression of HXT genes, leading to accumulation of glucose transporters in the plasma membrane (By similarity). SNF3 is involved as well in the transport of mannose and fructose (PubMed:20014043). Even though SNF3 is similar to glucose transporters, it appears to be unable to transport glucose (PubMed:9564039).
- substrates: glucose
- Multiple roles for the cytoplasmic C-terminal domains of the yeast cell surface receptors Rgt2 and Snf3 in glucose sensing and signaling.
Kim, Scientific reports 2024 - GeneRIF: Multiple roles for the cytoplasmic C-terminal domains of the yeast cell surface receptors Rgt2 and Snf3 in glucose sensing and signaling.
- The glucose metabolite methylglyoxal inhibits expression of the glucose transporter genes by inactivating the cell surface glucose sensors Rgt2 and Snf3 in yeast.
Roy, Molecular biology of the cell 2016 - GeneRIF: Rgt2 and Snf3 glucose sensors are primary targets of methylglyoxal, which causes degradation of the Rgt2 and Snf3.
- Disruption of Snf3/Rgt2 glucose sensors decreases lifespan and caloric restriction effectiveness through Mth1/Std1 by adjusting mitochondrial efficiency in yeast.
Choi, FEBS letters 2015 (PubMed)- GeneRIF: Mth1 and Std1, which are downstream effectors of the Snf3/Rgt2 pathway, were required for viability through mitochondrial function but not fermentative metabolism
- Amino acid residues involved in ligand preference of the Snf3 transporter-like sensor in Saccharomyces cerevisiae.
Dietvorst, Yeast (Chichester, England) 2010 (PubMed)- GeneRIF: This study reveals that Snf3, in addition to glucose, also senses fructose and mannose, as well as the glucose analogues 2-deoxyglucose, 3-O-methylglucoside and 6-deoxyglucose.
- Conditions with high intracellular glucose inhibit sensing through glucose sensor Snf3 in Saccharomyces cerevisiae.
Karhumaa, Journal of cellular biochemistry 2010 (PubMed)- GeneRIF: Snf3 apparent affinity for glucose was lowest when the intracellular glucose concentration was high. The results conform to an alternating-access model for transporter-like sensors
- Loss of IRA2 suppresses the growth defect on low glucose caused by the snf3 mutation in Saccharomyces cerevisiae.
Ramakrishnan, FEMS yeast research 2007 (PubMed)- GeneRIF: Suppression of the snf3 mutant phenotype by deletion of IRA2 was confirmed.
- TranCEP: Predicting the substrate class of transmembrane transport proteins using compositional, evolutionary, and positional information.
Alballa, PloS one 2020 - “...1203 columns, only 128 of them are informative (highlighted in shades of red). In (b) P10870 contains 884 residues, and the alignment of P10870 with other homologous sequences has 1312 columns, only 402 of them are informative. In (c) P11551 contains 438 residues, and the alignment...”
- “...%Seq Num %Seq Num %Seq P39515 158 4 80 113 71.51 73 91.25 40 51.28 P10870 884 12 252 402 45.47 243 96.42 159 25.15 P11551 438 12 252 252 57.53 148 58.73 94 55.91 P0AAT4 415 5 105 208 50.12 41 39.05 167 53.87 The...”
- Comparative genomics of the white-rot fungi, Phanerochaete carnosa and P. chrysosporium, to elucidate the genetic basis of the distinct wood types they colonize
Suzuki, BMC genomics 2012 - “...NcNCU08114 (XP_963873.1), NcRco3 (CAE76420), Pp_115604 (EED81359), Ps_ABN65648.2 (ABN65648.2), PsSut1 (AAD00266), ScHxt1 (M82963), ScHxt7 (NP_010629), ScSnf3 (P10870), SpGht1 (Q9P3U6), Tm-CAZ81962.1 (CAZ81962.1), TrHxt1 (AAR23147), TrXlt1 (shown enlarged; AY818402), TrHxt2 (DQ852622; Ruohonen and Margolles-Clark, unpublished). The sequences were aligned using MAFFT, and the tree was drawn by FigTree. In...”
- Major facilitator superfamily
Pao, Microbiology and molecular biology reviews : MMBR 1998 - “...P38156 P15685 P18631 X96876 Q10710 P38142 S58778 U32274 P43562 Z72626 P40441 P47186 P10870 P39932 GB SP GB SP SP SP SP SP SP SP SP SP SP SP SP SP SP GB SP GB SP...”
- Identifier Mapping in Cytoscape
Treister, F1000Research 2018 - “...Cytoscape can be loaded from the Starter Panel and provides gene identifiers of the form YDL194W. These are actually Ensembl-supported identifiers for Yeast, distinct from the typical ENSXXXG00000123456 form as presented in Table 1 . This presents a special case that users will need to be...”
- Widespread Cumulative Influence of Small Effect Size Mutations on Yeast Quantitative Traits
Hua, Cell systems 2018 - “...the raw data. These genes are: GAL4 (YPL248C), GCN4 (YEL009C), GAL80 (YML051W), GAL1 (YBR020W), SNF3 (YDL194W), STI1 (YOR027W), REG1 (YDR028C), GAL3 (YDR009W), SNF2 (YOR290C), HSC82 (YMR186W) . This is important when calculating the explained heritability for top N genes (see main text). One of our main...”
- Extensive Copy Number Variation in Fermentation-Related Genes Among Saccharomyces cerevisiae Wine Strains
Steenwyk, G3 (Bethesda, Md.) 2017 - “...HXT10 / YFL011W , HXT16 / YJR158W , RGT2 / YDL138W , and SNF3 / YDL194W ) of the HXT gene family ( Figure 3 ). Interestingly, all remaining 10 members of the HXT gene family were not CN variable. Altogether, examination of the HXT family...”
- Acetylated Deoxynivalenol Generates Differences of Gene Expression that Discriminate Trichothecene Toxicity
Suzuki, Toxins 2016 - “...Description YKL038W RGT1 nucleus Glucose-responsive transcription factor YDL138W RGT2 plasma membrane Plasma membrane glucose sensor YDL194W SNF3 plasma membrane Plasma membrane low glucose sensor YHR094C HXT1 plasma membrane Low-affinity glucose transporter YMR011W HXT2 plasma membrane High-affinity glucose transporter YHR092C HXT4 plasma membrane High-affinity glucose transporter The...”
- Genome-Wide Transcription Study of Cryptococcus neoformans H99 Clinical Strain versus Environmental Strains
Movahed, PloS one 2015 - “...# BUD8 Bud-site-selection protein 8 40.5 37.5 62.5 0.0267 CNAG_03433T0_1016 15.3 15.4 10.7 0.0116 CNAG_03772T0_1438 NP_010087 SNF3 High-affinity glucose transporter SNF3 15.2 8.0 5.5 0.0113 CNAG_03477T0_50 NP_010667.1 RGA2 Rho GTPase-activating protein 2 13.6 7.2 11.9 0.0150 CNAG_05426T0_545 NP_013064.1 # PRP19 E3 ubiquitin-protein ligase PRP19 13.1 5.2...”
- Phylogenetic and Transcripts Profiling of Glucose Sensing Related Genes in Candida glabrata
Ng, Jundishapur journal of microbiology 2015 - “...Target Gene Name Systematic Name Accession Number No. of Amino Acids Molecular Mass, kDa SNF3 YDL194W CAA98771 884 96.7 RGT2 YDL138W CAA65621 763 83.1 RGT1 YKL038W CAA81873 1170 128.2 MIG1 YGL035C CAA96736 504 55.6 HXT1 YHR094C DAA06789 570 63.3 HXT2 YMR011W DAA09909 541 59.8 HXT3 YDR345C...”
- Improved production of a heterologous amylase in Saccharomyces cerevisiae by inverse metabolic engineering
Liu, Applied and environmental microbiology 2014 - “...SNV Description M715 YBR018C YBR026C YBR120C YBR295W YKR105C YDL194W YDR050C YGR047C YGR083C YHL038C YKL148C GAL7 ETR1 CBP6 PCA1 NA SNF3 TPI1 TFC4 GCD2 CBP2...”
- Genome-wide integration on transcription factors, histone acetylation and gene expression reveals genes co-regulated by histone modification patterns
Natsume-Kitatani, PloS one 2011 - “...MSN2 (NP_013751), MSN4 (NP_012861), MTH1 (NP_010563), PIM1 (NP_002639), RAP1 (NP_014183), RGT2 (NP_010143), SIR2 (NP_010242), SNF3 (NP_010087) and SUP2 (NP_010457). Implementation The source code of our method, which was implemented in MATLAB ( http://www.mathworks.com/ ), is available from the supporting page for this paper: http://www.bic.kyoto-u.ac.jp/pathway/natsume/hm_detector.htm . Results...”
- More
TC 2.A.1.1.117 / G4N740 Glucose transporter Rco-3 or MoST1. MoST1 plays a specific role in conidiation and mycelial melanization which is not shared by other hexose transporter family members in M. oryzae from Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
XP_003716272 glucose transporter rco-3 from Pyricularia oryzae 70-15
34% identity, 88% coverage
Pc12g02080 uncharacterized protein from Penicillium rubens
33% identity, 94% coverage
FGSG_02641 hypothetical protein from Fusarium graminearum PH-1
34% identity, 90% coverage
ECDD_ASPRU / K0E3U9 Major facilitator-type transporter ecdD from Aspergillus rugulosus (Emericella rugulosa) (see paper)
32% identity, 98% coverage
Q6CCU6 YALI0C06424p from Yarrowia lipolytica (strain CLIB 122 / E 150)
34% identity, 93% coverage
CNM02570 receptor from Cryptococcus neoformans var. neoformans JEC21
33% identity, 96% coverage
- Comparative hybridization reveals extensive genome variation in the AIDS-associated pathogen Cryptococcus neoformans
Hu, Genome biology 2008 - “...and CNM02600, were conserved in all of the strains (H99, Bt63, 125.91, and CBS7779). However, CNM02570, which encodes a putative receptor protein near to the telomere, was present in H99, Bt63, CBS7779, and WM626, but not in 125.91. Kavanaugh and coworkers [ 61 ] found that...”
CNBG_9639 uncharacterized protein from Cryptococcus deuterogattii R265
33% identity, 96% coverage
HPODL_03366 High-affinity glucose transporter SNF3 from Ogataea parapolymorpha DL-1
33% identity, 93% coverage
NCU04963 high-affinity glucose transporter from Neurospora crassa OR74A
Q7S3Q4 High-affinity glucose transporter from Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
33% identity, 91% coverage
- Revisiting 2-Deoxyglucose Resistance in Neurospora crassa: Insights into Transcriptional Regulation of Hexose Transporters, Sugar Metabolism and Possible Modulation by Mating Type
Pandey, 2023 - The F-box protein gene exo-1 is a target for reverse engineering enzyme hypersecretion in filamentous fungi
Gabriel, Proceedings of the National Academy of Sciences of the United States of America 2021 (secret) - Evaluating the circadian rhythm and response to glucose addition in dispersed growth cultures of Neurospora crassa
Kelliher, Fungal biology 2020 - “...components of System I: glt-1 (NCU01633), and of System II: hgt-1 and hgt-2 (NCU10021 and NCU04963) ( Wang et al., 2017 ). The K m values for all three transporters fall within the ranges of earlier work ( Wang et al., 2017 ). Gene expression levels...”
- “...and high affinity (Km 0.1 mM) glucose transporters in low environmental glucose concentrations. Interestingly, hgt-2 (NCU04963) is reported to be a clock-controlled gene from fungal discs cultured in Bird 1.8% glucose ( Hurley et al., 2014 ). Single knockouts of hgt-2 (FGSC18806) or hgt-1 (FGSC22818) have...”
- The regulatory and transcriptional landscape associated with carbon utilization in a filamentous fungus
Wu, Proceedings of the National Academy of Sciences of the United States of America 2020 - “...relative to WT were bound by CRE-1. These MFS sugar transporters included NCU04537 (monosaccharide transporter), NCU04963 (high-affinity glucose transporter), NCU06026 (quinate permease), NCU05897 ( sut-28 ), NCU10021 ( hgt-1 ), NCU00821 (sugar transporter), and NCU05627 (high-affinity glucose transporter ght-1 ). The remaining set of 21 genes...”
- Deletion of the middle region of the transcription factor ClrB in Penicillium oxalicum enables cellulase production in the presence of glucose
Gao, The Journal of biological chemistry 2019 (secret) - A fungal transcription factor essential for starch degradation affects integration of carbon and nitrogen metabolism
Xiong, PLoS genetics 2017 - “...less than 1e-20 identified 14 genes likely encoding transporters. Four of them, hgt-1 (NCU10021), NCU05627, NCU04963, and NCU04537 are annotated as sugar transporter genes ( Fig 2C ). hgt-1 shows high affinity glucose transport activity [ 19 ], while NCU05627 ( xyt-1 ) has xylose transporting...”
- “..., the starch-active LPMO (NCU08746), gh13-6 and 19 transporter genes including hgt-1 , xyt-1 , NCU04963, and NCU04537 ( Fig 3C ). Seventeen TF genes in the starch regulon were also down regulated in the col-26 mutant, including tah-1 , tah-3 , vad-2 , ada-5 ,...”
- Identification and characterization of the glucose dual-affinity transport system in Neurospora crassa: pleiotropic roles in nutrient transport, signaling, and carbon catabolite repression
Wang, Biotechnology for biofuels 2017 - “...crassa . One low-affinity glucose transporter, GLT-1 (NCU01633), and two high-affinity transporters, HGT-1/-2 (NCU10021 and NCU04963), were identified as the major components of systems I and II, respectively. Simultaneous deletion of hgt - 1/ - 2 (strain 2hgt ) resulted in a notable increase in cellulolytic...”
- “...putative sucrose transporter NCU00450, the high-affinity glucose transporter hgt - 1 [ 40 ], and NCU04963 (designated as high-affinity glucose transporter hgt - 2 ; see the next paragraph). The glucose transporter glt - 1 was the only transporter that was constantly expressed on high glucose...”
- Understanding the Role of the Master Regulator XYR1 in Trichoderma reesei by Global Transcriptional Analysis
Dos, Frontiers in microbiology 2016 - “...from T. reesei and other species ( Saccharomyces cerevisiae YHR094C, YHR092C, YDR343C; Neurospora crassa NCU00821, NCU04963, NCU08114, NCU10021; Aspergillus nidulans AN3199, AN6831; Aspergillus oryzae AO090103000130, AO090038000233; Aspergillus niger XP_001397059.2; Escherichia coli YP006127731.1; Metarhizium anisopliae GQ167043.1, EFY97396.1, EFY94560.1; Talaromyces marneffei XP002152585.1; Talaromyces stipitatus XP002484658.1; Candida albicans 19.13383,...”
- More
- Advances in fungal sugar transporters: unlocking the potential of second-generation bioethanol production
Pereira, Applied microbiology and biotechnology 2025 - “...( 2020 ) HGT-1 Q7S0I5 Glucose N. crassa Wang et al. ( 2017a ) HGT-2 Q7S3Q4 Glucose N. crassa Wang et al. ( 2017a ) GLT-1 Q1K4S3 Glucose and xylose N. crassa Li et al. ( 2014 ); Wang et al. ( 2017a ) NCU00809 Q7SEC5...”
SS1G_06023 hypothetical protein from Sclerotinia sclerotiorum 1980 UF-70
34% identity, 86% coverage
XP_042994564 uncharacterized protein from Ustilaginoidea virens
33% identity, 81% coverage
AFUA_4G00800, Afu4g00800 MFS monosaccharide transporter, putative from Aspergillus fumigatus Af293
35% identity, 87% coverage
- Broad-spectrum antimicrobial activities of a food fermentate of Aspergillus oryzae
Choi, Microbiology spectrum 2024 - “...transporter 4.76 AFUA_8G02550 Putative MFS peptide transporter 4.40 AFUA_8G05710 mfsA Putative MFS sugar transporter 3.94 AFUA_4G00800 Putative monosaccharide transporter 3.55 AFUA_3G11790 Putative galactose-proton symport 3.06 AFUA_8G06870 Putative MFS sugar transporter 2.99 AFUA_8G02010 Putative MFS sugar transporter 2.95 AFUA_1G16690 Putative MFS sugar transporter 2.75 AFUA_4G02870 Putative 2-ketogluconate...”
- Investigation of Aspergillus fumigatus biofilm formation by various "omics" approaches
Muszkieta, Frontiers in microbiology 2013 - “...Hypothetical protein 3.1 1.63 2.78 1.47 AFUA_1G09510 GPI anchored protein, putative 3.55 1.83 2.76 1.46 AFUA_4G00800 MFS monosaccharide transporter, putative 7.39 2.89 2.73 1.45 AFUA_5G08030 Cellulase CelA, putative 2.23 1.16 2.69 1.43 AFUA_7G04290 Amino acid permease (Gap1), putative 3.43 1.78 2.68 1.42 AFUA_5G03010 Conserved hypothetical protein...”
- Evolutionary Analysis of Sequence Divergence and Diversity of Duplicate Genes in Aspergillus fumigatus
Yang, Evolutionary bioinformatics online 2012 - “...0.66 [1.82, 1.82] Afu7g06080 2.10 [2.18, 1.29] Afu2g10140 0.72 [1.46, 1.23] Afu3g14010 2.18 [2.16, 1.22] Afu4g00800 0.74 [1.80, 1.71] Afu4g00990 2.37 [2.12, 0.95] Afu5g06230 0.76 [1.82, 1.74] Afu4g03370 1.32 [1.81, 1.21] Afu2g11600 0.82 [1.82, 1.65] Afu1g13320 0.99 [1.83, 1.53] Afu5g13290 0.82 [1.82, 1.68] Afu2g15730 2.52 [1.86,...”
- Sub-telomere directed gene expression during initiation of invasive aspergillosis
McDonagh, PLoS pathogens 2008 - “...(Hxt8) 4.701754948 Afu3g14030 alkaline phosphatase 3.3131505 Afu5g14540 MFS monosaccharide transporter 4.683929957 Afu2g00490 glycosyl hydrolase 4.8648019 Afu4g00800 MFS monosaccharide transporter 4.678081027 Afu7g06380 maltase 5.0594343 Afu7g00780 MFS monocarboxylate transporter 4.659742223 Afu8g01050 lipase/esterase 2.7697017 Afu3g03320 MFS monocarboxylate transporter 4.62947329 Afu3g14910 extracellular signalling protein (factor C) 3.0355716 Afu3g03240 MFS monocarboxylate...”
VDAG_02979 high-affinity glucose transporter RGT2 from Verticillium dahliae VdLs.17
33% identity, 95% coverage
- Verticillium dahliae-Arabidopsis Interaction Causes Changes in Gene Expression Profiles and Jasmonate Levels on Different Time Scales
Scholz, Frontiers in microbiology 2018 - “...gene ( WAKL10 , Meier et al., 2010 ) were chosen for the plant and VDAG_02979 (a glucose transporter) and VDAG_06565 (poly-A-ribonuclease, PARN) for the fungus. In the RNA-seq analysis, the expression of WAKL10 was 56-fold induced in V. dahliae -infested plants compared to plants grown...”
- “...for 24 h. Shown is the normalized fold expression ( SE, n = 3) of VDAG_02979 (A) and VDAG_06565 (PARN) (B) in VD -colonized WT, jar1, coi1-16 , and cyp94B3 plants. The expression level of GOIs in VD alone was used as control and set to...”
PGTG_18584 uncharacterized protein from Puccinia graminis f. sp. tritici CRL 75-36-700-3
33% identity, 93% coverage
TC 2.A.1.1.109 / P42833 Hexose transporter HXT14 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 3 papers)
YNL318C Hxt14p from Saccharomyces cerevisiae
32% identity, 86% coverage
- substrates: Hexoses
- Yeast Double Transporter Gene Deletion Library for Identification of Xenobiotic Carriers in Low or High Throughput
Almeida, mBio 2021 - “...YLR237W, YML047C, YML116W, YML123C, YMR011W, YMR177W, YMR243C, YMR279C, YMR319C, YNL065W, YNL142W, YNL268W, YNL270C, YNL275W, YNL291C, YNL318C, YNR002C, YNR055C, YNR056C, YNR072W, YOL020W, YOL103W, YOL122C, YOL158C, YOR011W, YOR071C, YOR153W, YOR192C, YOR202W, YOR273C, YOR306C, YOR328W, YOR348C, YPL036W, YPL058C, YPL092W, YPL265W, YPL274W, YPR124W, YPR138C, YPR156C, YPR192W, YPR198W, and YPR201W (...”
- Improved Xylose Metabolism by a CYC8 Mutant of Saccharomyces cerevisiae
Nijland, Applied and environmental microbiology 2017 - “...YHR094C YJL214W YDL245C YJR158W YEL069C YFL011W YJL219W YOL156W YLR081W YNL318C Sum of all HXTs Sum of all genes Gene HXT2 HXT36 HXT7 HXT4 HXT5 HXT1 HXT8 HXT15...”
- The transcriptional repressor Sum1p counteracts Sir2p in regulation of the actin cytoskeleton, mitochondrial quality control and replicative lifespan in Saccharomyces cerevisiae
Higuchi-Sanabria, Microbial cell (Graz, Austria) 2016 - “...than 1000-fold overexpression of several previously uncharacterized open reading frames, such as YGl138c, YLR308W, and YNL318c . It is possible that these genes contribute to Sir2p-dependent and/or Sir2p-independent control of lifespan. Materials and Methods Yeast Growth Conditions Yeast cells were cultivated and manipulated as previously described...”
- Phylogenetic and Transcripts Profiling of Glucose Sensing Related Genes in Candida glabrata
Ng, Jundishapur journal of microbiology 2015 - “...YFL011W DAA12428 546 60.7 HXT11 YOL156W DAA10630 567 62.7 HXT13 YEL069C DAA07586 564 62.7 HXT14 YNL318C CAA96250 540 61.0 HXT15 YDL245C DAA11622 567 62.9 HXT16 YJR158W DAA08942 567 62.9 HXT17 YNR072W DAA10613 564 62.8 3.2. Phylogenetic Analysis The multiple sequence alignment of selected amino acid sequences...”
- RSC Chromatin-Remodeling Complex Is Important for Mitochondrial Function in Saccharomyces cerevisiae
Imamura, PloS one 2015 - “...space Cysteine motif protein YNL009W IDP3 -1.957974411 Isocitrate Dehydrogenase, NADP-specific YNL104C LEU4 -1.326612984 LEUcine biosynthesis YNL318C HXT14 -1.082656945 HeXose Transporter YOL045W PSK2 -1.053181566 Pas domain-containing Serine/threonine protein Kinase YPL091W GLR1 -1.926695216 Cytosolic and mitochondrial glutathione oxidoreductase Organigation YBR179C FZO1 -1.630212553 FuZzy Onions homolog YHR194W MDM31 -1.336269739...”
- Standing genetic variation drives repeatable experimental evolution in outcrossing populations of Saccharomyces cerevisiae
Burke, Molecular biology and evolution 2014 - “...in YBR184W, a histidine to arginine polymorphism in YNL318C, and a glycine to serine polymorphism in UFE1 (supplementary table S1, Supplementary Material...”
- Sum1 and Ndt80 proteins compete for binding to middle sporulation element sequences that control meiotic gene expression
Pierce, Molecular and cellular biology 2003 - “...SUM1 SD YHR091C YAL018C YGR059W YCL026C-A YDR522C YNL318C YLR307W YBL098W YLR343W YGL138C YFL012W YHR090C YOR365C YBR045C YLR232W YJL037W YDR523C YNL319W...”
- Optimizing pentose utilization in yeast: the need for novel tools and approaches
Young, Biotechnology for biofuels 2010 - “...TMB3201 - Saccharomyces cerevisiae HXT13 P39924 p4H7 [ 64 ] TMB3201 - Saccharomyces cerevisiae HXT14 P42833 p4H7 [ 64 ] TMB3201 - Saccharomyces cerevisiae HXT15 P54854 p4H7 [ 64 ] TMB3201 - Saccharomyces cerevisiae GAL2 P13181 pHL125 [ 64 ] TMB3201 + Several previous studies have...”
- Major facilitator superfamily
Pao, Microbiology and molecular biology reviews : MMBR 1998 - “...P32467 P38695 P39003 P39004 P40886 P43581 P40885 P39924 P42833 P47185 Z71687 P30605 X98622 P30606 S51081 P07921 P38156 P15685 P18631 X96876 Q10710 P38142 S58778...”
ATEG_07144 uncharacterized protein from Aspergillus terreus NIH2624
34% identity, 87% coverage
- Transcriptome Profiling-Based Analysis of Carbohydrate-Active Enzymes in Aspergillus terreus Involved in Plant Biomass Degradation
Corrêa, Frontiers in bioengineering and biotechnology 2020 - “...SH during the 48 h incubation period, namely ATEG_07791, ATEG_03475, ATEG_07105, ATEG_04988, ATEG_01556, ATEG_07124, ATEG_08653, ATEG_07144, ATEG_03527, ATEG_02489, ATEG_07114, ATEG_04070, ATEG_07053, ATEG_04137, ATEG_03190, and ATEG_05008. RT-qPCR Validation of in silico RNA-Seq Transcriptome Data Expression profiles for selected A. terreus CAZyme-encoding and other genes significantly up-regulated on...”
A2R055 Contig An12c0230, genomic contig from Aspergillus niger (strain ATCC MYA-4892 / CBS 513.88 / FGSC A1513)
An12g07450 uncharacterized protein from Aspergillus niger
35% identity, 87% coverage
- Advances in fungal sugar transporters: unlocking the potential of second-generation bioethanol production
Pereira, Applied microbiology and biotechnology 2025 - “...Tr69957 G0RW02 Cellobiose, xylose, and mannose T. reesei Nogueira et al. ( 2018 ) MstA A2R055 Glucose, xylose, fructose, and mannose A. niger vankuyk et al. ( 2004 ); Jrgensen et al. ( 2007 ) MstG XP_025453682 Glucose, galactose, mannose, and sucrose A. niger Sloothaak et...”
- The antifungal peptide AnAFP from Aspergillus niger promotes nutrient mobilization through autophagic recycling during asexual development
Starke, Frontiers in microbiology 2024 - “...1.1E-02 An15g03200 Thiamine transporter, mitochondrial membrane tpc1 1.12 3.9E-02 An12g00870 Malate permease ssu1 -1.08 4.9E-02 An12g07450 Hig-affinity sugar/H+ symporter mstA -1.25 1.2E-02 An15g07460 Oligopeptide transporter optG -1.58 3.2E-02 An08g05450 ATPase mdr4 -1.63 3.4E-02 An08g03850 Quinate permease qutD -1.81 4.8E-07 An12g04180 Aspartate transporter agtA -1.99 1.1E-02 An15g07190...”
- The amyR-deletion strain of Aspergillus niger CICC2462 is a suitable host strain to express secreted protein with a low background
Zhang, Microbial cell factories 2016 - “...215.81 17.92 3.59 0 Endoprotease Sugar transporter An15g03940 1891.82 158.73 3.58 0 Glucose transporter rco-3 An12g07450 372.55 6.95 5.74 0 Sugar transporter An01g00850 117.57 2.28 5.69 0 Sugar transporter An02g00590 258.7 14.23 4.18 0 Sugar transporter Table6 Positions of the possible amyR binding sites CGGN8CGG CGGN8AGG...”
- “...None None Serine-type carboxypeptidase F An15g03940 554 to 567 None None None Glucose transporter rco-3 An12g07450 None None 702 to 715 885 to 898 867 to 880 Sugar transporter An01g00850 None None 758 to 771 None Sugar transporter An02g00590 None 857 to 870 602 to 615...”
- Metabolic activity in dormant conidia of Aspergillus niger and developmental changes during conidial outgrowth
Novodvorska, Fungal genetics and biology : FG & B 2016 - “...An05g01290 2.8 324.2 Monosaccharide transporter An16g08940 5.1 118.8 Monosaccharide transporter An02g01270 1.6 25.8 Monosaccharide transporter An12g07450 1.6 9.5 High affinity sugar/H+symporter, mstA An02g01560 0.1 1.4 GPCR An09g06510 6.1 2.8 GPCR An08g04110 1.4 4.8 GPCR An07g09280 4.7 17.4 GPCR An01g00400 0.8 1.2 GPCR An08g06130 8.6 89.2 GTP-binding...”
- Cytosolic streaming in vegetative mycelium and aerial structures of Aspergillus niger
Bleichrodt, Studies in mycology 2013 - “...5 Ubi4 - Saccharomyces cerevisiae An14g04920 1349 Triose-phosphate-isomerase tpiA from patent WO8704464-A - Aspergillus niger An12g07450 1332 Strong similarity to glucose permease Rgt2 - Saccharomyces cerevisiae An18g05640 1322 Strong similarity to hypothetical mold-specific protein MS8 - Ajellomyces capsulatus An01g02900 1299 Strong similarity to translation initiation factor...”
- Genome-wide expression analysis upon constitutive activation of the HacA bZIP transcription factor in Aspergillus niger reveals a coordinated cellular response to counteract ER stress
Carvalho, BMC genomics 2012 - “...10 An11g01100 strong similarity to high-affinity glucose transporter HGT1 - K. lactis 5 5 5 An12g07450 mstA Sugar/H+symporter 5 10 10 *Not significantly differentially expressed. The down-regulation of genes involved in starch degradation and uptake suggested that the HacA CA mutants growth may be severely affected...”
- The carbon starvation response of Aspergillus niger during submerged cultivation: insights from the transcriptome and secretome
Nitsche, BMC genomics 2012 - “...it can be assumed that these predicted sugar transporters comprise high-affinity sugar transporters. Indeed, mstA (An12g07450) and mstF (An02g00590) encoding two high-affinity sugar/H + symporters [ 32 ] were significantly upregulated at day 1 and 3 as well as day 1, 3 and 6, respectively. Furthermore,...”
- Transcriptome analysis of Aspergillus niger grown on sugarcane bagasse
de, Biotechnology for biofuels 2011 - “...encoding putative transporters that could be involved in carbohydrate transport, such as An1503940, An14g01600 and An12g07450 ( N. crassa NCU04963, NCU05853 and NCU10021, respectively), have increased mRNA accumulation in the presence of both SEB and Miscanthus (Additional file 5 , Table S5). Genes involved in the...”
- Aspergillus niger genome-wide analysis reveals a large number of novel alpha-glucan acting enzymes with unexpected expression profiles
Yuan, Molecular genetics and genomics : MGG 2008 - “...alpha-amylase AmyC An09g04810 18.470.44 P 6.460.35 P 2.520.02 P 2.9 7.4 0.003 Putative hexose transporter An12g07450 137.6013.00 P 51.5711.82 P 52.506.31 P 2.7 2.6 0.064 Sugar/H+ symporter MstA Energy An03g06270 4.720.29 P 1.590.14 A 0.200.25 A 3.3 25.6 0.035 Putative isoamyl alcohol oxidase An16g06010 5.181.55 P...”
TC 2.A.1.1.57 / Q8J0V1 High affinity (15 μM) glucose (monosaccharides including xylose):H+ symporter, MstA from Aspergillus niger
35% identity, 87% coverage
NCU04537 monosaccharide transporter from Neurospora crassa OR74A
35% identity, 87% coverage
- Correlating sugar transporter expression and activities to identify transporters for an orphan sugar substrate
Tamayo, Applied microbiology and biotechnology 2024 - “...crassa . For d -mannose, putative monosaccharide transporters from cluster 1 (like XYT-1, FRT-1, HGT-2, NCU04537, HGT-1, QaY, NCU06358, GLT-1, NCU06384, and NCU06138) could be potential candidates, but likely also only by contributing with unspecific side activities. Lactose uptake assays of transporter candidates Following the previous...”
- The regulatory and transcriptional landscape associated with carbon utilization in a filamentous fungus
Wu, Proceedings of the National Academy of Sciences of the United States of America 2020 - “...( 25 ). Of the predicted sugar transporters in this clade, five unannotated MFS transporters (NCU04537, NCU05350, NCU05585, NCU06384, and NCU07607) had increased expression on unique sugars and complex carbon sources, suggesting potential involvement in catabolism of those carbon sources ( SI Appendix , Fig. S1...”
- “...high-affinity glucose transporter, hgt-1 NCU10021 ( 35 ) and additional uncharacterized transporters (NCU00809, NCU06522, NCU09287, NCU04537, NCU01494, NCU06384, and NCU05897). An uncharacterized sugar transporter bound by CRE-1, sut-28 (NCU05897; annotated as a fucose permease; SI Appendix , Fig. S1 ), is a predicted ortholog of the...”
- Molecular Mechanisms of Chitosan Interactions with Fungi and Plants
Lopez-Moya, International journal of molecular sciences 2019 - “...deletion strain mutants confirms Lipase Class III, Monosaccharide transporter and Glutathione transferase encoding genes (NCU03639; NCU04537; NCU10521, respectively) as main chitosan targets in N. crassa [ 36 ]. They might play a role in membrane repair, assimilation of catabolites and buffering ROS surplus derived from chitosan...”
- Control of Development, Secondary Metabolism and Light-Dependent Carotenoid Biosynthesis by the Velvet Complex of Neurospora crassa
Bayram, Genetics 2019 - “...on 22 May 2021 Log2Fold change NCU10101 (llmG) NCU04537 NCU10761 (llmA) NCU03016 NCU00292 NCU00943 NCU08648 Table 2 Top 10 upregulated genes under standard...”
- A fungal transcription factor essential for starch degradation affects integration of carbon and nitrogen metabolism
Xiong, PLoS genetics 2017 - “...1e-20 identified 14 genes likely encoding transporters. Four of them, hgt-1 (NCU10021), NCU05627, NCU04963, and NCU04537 are annotated as sugar transporter genes ( Fig 2C ). hgt-1 shows high affinity glucose transport activity [ 19 ], while NCU05627 ( xyt-1 ) has xylose transporting activity [...”
- “...starch-active LPMO (NCU08746), gh13-6 and 19 transporter genes including hgt-1 , xyt-1 , NCU04963, and NCU04537 ( Fig 3C ). Seventeen TF genes in the starch regulon were also down regulated in the col-26 mutant, including tah-1 , tah-3 , vad-2 , ada-5 , and kal-1...”
- Regulated Forms of Cell Death in Fungi
Gonçalves, Frontiers in microbiology 2017 - “...Kontoyiannis, 2013a , b Chitosan N. crassa, Fusarium eumartii Nc : NCU03639 (class 3 lipase), NCU04537 (monosaccharide trans-porter), NCU10521 (gluta-thione S-transferase-4) Yes NA NA Palma-Guerrero et al., 2009 ; Terrile et al., 2014 ; Lopez-Moya et al., 2016 PLANT-DERIVED COMPOUNDS Camalexin Botrytis cinerea Bc : BcBir1...”
- Neurospora crassa transcriptomics reveals oxidative stress and plasma membrane homeostasis biology genes as key targets in response to chitosan
Lopez-Moya, Molecular bioSystems 2016 - “...NCU03639 encoding a class 3 lipase, involved in plasma membrane repair by lipid replacement and NCU04537 a MFS monosaccharide transporter related with assimilation of simple sugars, as main gene targets of chitosan. NCU10521, a glutathione S-transferase-4 involved in the generation of reducing power for scavenging intracellular...”
- “...stress (NCU05134 and NCU08907) and a monosaccharide transporter perhaps involved in chitosan assimilation or detoxification (NCU04537, fold-induction 9.27 after 16h growing with chitosan). Besides, other genes related with sugars assimilation were also induces in presence of chitosan such as NCU01633 ( hxt13 ; Table S2 )....”
- Direct target network of the Neurospora crassa plant cell wall deconstruction regulators CLR-1, CLR-2, and XLR-1
Craig, mBio 2015 - “...in xylobiose or xylose utilization and a xylose/glucose transporter. In addition, other uncharacterized sugar transporters (NCU04537 and NCU05350) and two hypothetical proteins (NCU06490 and NCU07510) were in this gene set ( Table3 ). TABLE3 Genes upregulated and differentially expressed in the wild-type strains versus a xlr-1...”
- “...a gh43-2 Xylosidase/arabinosidase NCU02343 gh51-1 Alpha- l -arabinofuranosidase NCU03322 GDSL family lipase NCU04401 Fructose-bisphosphate aldolase NCU04537 Monosaccharide transporter NCU04870 a ce1 - 1 Acetyl xylan esterase NCU05159 ce5 - 2 Acetyl xylan esterase NCU05350 Major facilitator transporter NCU06138 xy-31 Xylose transporter NCU06143 gh115-1 Putative glucuronidase NCU06490...”
- More
XP_449525 hypothetical protein from Candida glabrata CBS 138
35% identity, 87% coverage
- Phylogenetic and Transcripts Profiling of Glucose Sensing Related Genes in Candida glabrata
Ng, Jundishapur journal of microbiology 2015 - “...XP_445530 564 62.4 HXT2/10 CAGL0D02640 XP_445530 564 62.4 HXT2/10 CAGL0I00286 XP_447265 555 61.7 HXT14 CAGL0M04103 XP_449525 531 59.0 Table 2. Details of Glucose Sensing-Related Genes of Saccharomyces cerevisiae Target Gene Name Systematic Name Accession Number No. of Amino Acids Molecular Mass, kDa SNF3 YDL194W CAA98771 884...”
TC 2.A.1.1.64 / B1PM37 The hexose sensor, Hxs1 (believed to be non-transporting) from Pichia angusta (Yeast) (Hansenula polymorpha) (see paper)
31% identity, 82% coverage
SS1G_08425 hypothetical protein from Sclerotinia sclerotiorum 1980 UF-70
32% identity, 92% coverage
SNF3 glucose sensor from Candida albicans (see paper)
XP_723173 glucose sensor from Candida albicans SC5314
31% identity, 69% coverage
- CharProtDB CGD description: glucose and galactose sensor; fermentation, filamentation, virulence roles; in 20-member C. albicans glucose transporter family, extended C terminus; high-glucose repressed; induced in macrophage, repressed in biofilm
- Comparative genomics of the white-rot fungi, Phanerochaete carnosa and P. chrysosporium, to elucidate the genetic basis of the distinct wood types they colonize
Suzuki, BMC genomics 2012 - “...of corresponding sequences are: AnHyp1 (XP_682442.1), AnHyp2 (XP_660070.1), AnMstA (CAC80843), Ao_BAE58341.1 (BAE58341.1), CaHgt1 (CAA76406), CaHgt4 (XP_723173), CaHgt11 (XP_719597), CiGxf1 (AJ937350), CiGxs1 (AJ875406), GzHyp1 (EAA74528), HpGcr1 (AAR88143), KlHgt1 (XP_451484), KlRag1 (XP_453656), KlRag4 (CAA75114), Lb_EDR07962 (EDR07962), NcHyp1 (XP_328858), NcHxt3 (CAD21508), NcNCU00801(EAA34565.1), NcNCU08114 (XP_963873.1), NcRco3 (CAE76420), Pp_115604 (EED81359), Ps_ABN65648.2...”
- Catabolite repression of Aox in Pichia pastoris is dependent on hexose transporter PpHxt1 and pexophagy
Zhang, Applied and environmental microbiology 2010 - “...for HpGcr1, CAI44932 for CiGxs1, EU476007 for HpHxs1, XP_723173 for CaHgt4, CAA75114 for KlRag4, NP_010087 for ScSnf3, and NP_010143 for ScRgt2. cerevisiae and...”
- Identification of hexose transporter-like sensor HXS1 and functional hexose transporter HXT1 in the methylotrophic yeast Hansenula polymorpha
Stasyk, Eukaryotic cell 2008 - “...are as follows: AnMSTA, AAL89822; CaHgt4, XP_723173; CaHgt12, XP_888662; CiGxs1, CAI44932; CiGxf1, CAI77652; HpGcr1, AAR88143; HpHxt1, EU476006; HpHxs1,...”
RGT2_YEAST / Q12300 High glucose sensor RGT2; Low-affinity glucose receptor RGT2; Low-affinity transporter-like sensor RGT2; Restores glucose transport protein 2 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 4 papers)
TC 2.A.1.1.19 / Q12300 Glucose transporter and low affinity sensor, Rgt2p (regulates glucose transport in conjunction with Snf3p). Rgt2 generates an intracellular signal in response to glucose that leads to inhibition of the Rgt1 transcriptional repressor and consequently to derepression of HXT genes encoding glucose transporters. They have unusually long C-terminal tails that bind to Mth1 and Std1, paralogous proteins that regulate the function of the Rgt1 transcription factor from Saccharomyces cerevisiae (Baker's yeast) (see 4 papers)
RGT2 / RF|NP_010143.1 high-affinity glucose transporter RGT2 from Saccharomyces cerevisiae
NP_010143, YDL138W Plasma membrane glucose receptor, highly similar to Snf3p; both Rgt2p and Snf3p serve as transmembrane glucose sensors generating an intracellular signal that induces expression of glucose transporter (HXT) genes from Saccharomyces cerevisiae
NP_010143 glucose sensor from Saccharomyces cerevisiae S288C
33% identity, 61% coverage
- function: Low-affinity high glucose sensor that is part of the sensor/receptor-repressor (SSR) glucose-signaling pathway, which detects extracellular glucose and induces expression of glucose transporters that bring glucose into the cell (PubMed:14755054, PubMed:27630263, PubMed:9564039). The transporter-like sensor generates an intracellular signal in the presence of high levels of glucose to promote high glucose-induced expression of HXT1 (PubMed:9564039). Binding of glucose to the RGT2 transmembrane domain activates a downstream signaling cascade, leading to phosphorylation of the RGT1 corepressors MTH1 and STD1, targeting them for SCF(Grr1)-dependent ubiquitination and degradation. Depletion of the corepressors robs RGT1 of its ability to repress expression of HXT genes, leading to accumulation of glucose transporters in the plasma membrane (PubMed:27630263, PubMed:8901598). Even though RGT2 is similar to glucose transporters, it appears to be unable to transport glucose (PubMed:9564039).
subunit: Interacts with YCK1 (PubMed:14755054). Interacts with MTH1 and STD1 (PubMed:27630263). - substrates: glucose
tcdb comment: Scharff-Poulsen et al. 2018 showed that the C-terminal tail of Rgt2 is not responsible for its inability to transport glucose. RGT2 mutations that cause constitutive signal generation alter evolutionarily-conserved amino acids in the transmembrane spanning regions involved in maintaining an outward-facing conformation or the substrate binding site. These mutations may cause Rgt2 to adopt inward-facing or occluded conformations that generate the glucose signal - A Rab escort protein regulates the MAPK pathway that controls filamentous growth in yeast
Jamalzadeh, Scientific reports 2020 - “...wall/stress response; RSC3 has a paralog, RSC30, that arose from the whole genome duplication NA YDL138W RGT2 Restores Glucose Transport 12 <0.1 Plasma membrane high glucose sensor that regulates glucose transport low affinity sesnor that contains 12 predicted transmembrane segments and a long C-terminal tail required...”
- Extensive Copy Number Variation in Fermentation-Related Genes Among Saccharomyces cerevisiae Wine Strains
Steenwyk, G3 (Bethesda, Md.) 2017 - “..., HXT8 / YJL214W , HXT10 / YFL011W , HXT16 / YJR158W , RGT2 / YDL138W , and SNF3 / YDL194W ) of the HXT gene family ( Figure 3 ). Interestingly, all remaining 10 members of the HXT gene family were not CN variable. Altogether,...”
- Acetylated Deoxynivalenol Generates Differences of Gene Expression that Discriminate Trichothecene Toxicity
Suzuki, Toxins 2016 - “...in this study. Systematic Name Gene Symbol Localization Description YKL038W RGT1 nucleus Glucose-responsive transcription factor YDL138W RGT2 plasma membrane Plasma membrane glucose sensor YDL194W SNF3 plasma membrane Plasma membrane low glucose sensor YHR094C HXT1 plasma membrane Low-affinity glucose transporter YMR011W HXT2 plasma membrane High-affinity glucose transporter...”
- Phylogenetic and Transcripts Profiling of Glucose Sensing Related Genes in Candida glabrata
Ng, Jundishapur journal of microbiology 2015 - “...Accession Number No. of Amino Acids Molecular Mass, kDa SNF3 YDL194W CAA98771 884 96.7 RGT2 YDL138W CAA65621 763 83.1 RGT1 YKL038W CAA81873 1170 128.2 MIG1 YGL035C CAA96736 504 55.6 HXT1 YHR094C DAA06789 570 63.3 HXT2 YMR011W DAA09909 541 59.8 HXT3 YDR345C DAA12185 567 62.6 HXT4 YHR092C...”
- Genome-wide integration on transcription factors, histone acetylation and gene expression reveals genes co-regulated by histone modification patterns
Natsume-Kitatani, PloS one 2011 - “...MIG2 (NP_011306), MOF (NP_115564), MSN2 (NP_013751), MSN4 (NP_012861), MTH1 (NP_010563), PIM1 (NP_002639), RAP1 (NP_014183), RGT2 (NP_010143), SIR2 (NP_010242), SNF3 (NP_010087) and SUP2 (NP_010457). Implementation The source code of our method, which was implemented in MATLAB ( http://www.mathworks.com/ ), is available from the supporting page for this...”
- Catabolite repression of Aox in Pichia pastoris is dependent on hexose transporter PpHxt1 and pexophagy
Zhang, Applied and environmental microbiology 2010 - “...for CaHgt4, CAA75114 for KlRag4, NP_010087 for ScSnf3, and NP_010143 for ScRgt2. cerevisiae and also implied a special role for PpHxt2 in sugar fermentation in...”
- Identification of hexose transporter-like sensor HXS1 and functional hexose transporter HXT1 in the methylotrophic yeast Hansenula polymorpha
Stasyk, Eukaryotic cell 2008 - “...XP_453656; KlRag4, CAA75114; ScHxt1, M82963; ScSnf3, NP_010087; and ScRgt2, NP_010143. 740 STASYK ET AL. EUKARYOT. CELL Hxs1 and Gcr1 and to which most of the...”
- Role of PUG1 in inducible porphyrin and heme transport in Saccharomyces cerevisiae
Protchenko, Eukaryotic cell 2008 - “...49.1 2.3 1.9 36.1 4.0 2.3 14.1 3.3 2.1 28.0 2.5 1.5 YDL138W RGT2 12 3.4 3.5 3.6 3.2 YPL189W GUP2 10 2.3 2.6 3.0 2.3 6 2.8 2.0 2.8 2.4 Hexose transporter...”
- More
- Multiple roles for the cytoplasmic C-terminal domains of the yeast cell surface receptors Rgt2 and Snf3 in glucose sensing and signaling.
Kim, Scientific reports 2024 - GeneRIF: Multiple roles for the cytoplasmic C-terminal domains of the yeast cell surface receptors Rgt2 and Snf3 in glucose sensing and signaling.
- Genetic Analysis of Signal Generation by the Rgt2 Glucose Sensor of Saccharomyces cerevisiae.
Scharff-Poulsen, G3 (Bethesda, Md.) 2018 - GeneRIF: RGT2 constitutive mutations alter evolutionarily-conserved amino acids in the transmembrane spanning regions of Rgt2. They cause Rgt2 to adopt inward-facing or occluded conformations that generate the glucose signal.
- The glucose metabolite methylglyoxal inhibits expression of the glucose transporter genes by inactivating the cell surface glucose sensors Rgt2 and Snf3 in yeast.
Roy, Molecular biology of the cell 2016 - GeneRIF: Rgt2 and Snf3 glucose sensors are primary targets of methylglyoxal, which causes degradation of the Rgt2 and Snf3.
- Disruption of Snf3/Rgt2 glucose sensors decreases lifespan and caloric restriction effectiveness through Mth1/Std1 by adjusting mitochondrial efficiency in yeast.
Choi, FEBS letters 2015 (PubMed)- GeneRIF: Mth1 and Std1, which are downstream effectors of the Snf3/Rgt2 pathway, were required for viability through mitochondrial function but not fermentative metabolism
- Biochemical evidence for glucose-independent induction of HXT expression in Saccharomyces cerevisiae.
Pasula, FEBS letters 2007 - GeneRIF: RGT2-1 promotes ubiquitination and subsequent degradation of Mth1 and Std1 regardless of the presence of glucose.
Q5AYG1 Major facilitator superfamily (MFS) profile domain-containing protein from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)
33% identity, 87% coverage
AFUA_6G03060, Afu6g03060 MFS monosaccharide transporter, putative from Aspergillus fumigatus Af293
33% identity, 92% coverage
- Broad-spectrum antimicrobial activities of a food fermentate of Aspergillus oryzae
Choi, Microbiology spectrum 2024 - “...MFS monosaccharide transporter 2.25 AFUA_2G12500 Putative MFS multidrug transporter 2.25 AFUA_3G01840 Putative MFS transporter 2.25 AFUA_6G03060 Putative MFS monosaccharide transporter 2.14 AFUA_4G03750 Putative phthalate transporter 2.05 AFUA_6G03720 Putative MFS allantoate transporter 2.02 AFUA_4G00150 Putative MFS maltose transporter 2.01 AFUA_5G02840 Putative MFS sugar transporter 1.88 AFUA_7G06390 MalP...”
- Expression profile analysis reveals that Aspergillus fumigatus but not Aspergillus niger makes type II epithelial lung cells less immunological alert
Escobar, BMC genomics 2018 - “...3.07 Up Afu6g02280 (aspf3) 2.41 Up Aspni7|1,143,258 2.97 Down Afu6g02520 2.01 Up Aspni7|1,172,785 3.90 Up Afu6g03060 18.45 Up Aspni7|1,143,191 14.30 Up Afu6g11430 (aldA) 3.61 Up Aspni7|1,148,193 3.09 Up Afu6g13330 7.53 Up Aspni7|1,148,295 20.67 Up Afu7g05920 2.03 Up Aspni7|1,173,782 5.76 Up Afu1g01370 Switched off Down Aspni7|1,161,822 Switched...”
- Transcriptional and proteomic analysis of the Aspergillus fumigatus ΔprtT protease-deficient mutant
Hagag, PloS one 2012 - “...AFUA_6G11840 sodium:bile acid symporter involved in azole resistance 5.4 AFUA_4G01230 amino acid transporter, putative 5.2 AFUA_6G03060 MFS monosaccharide transporter 5.0 AFUA_1G12240 MFS peptide transporter, putaitve 4.6 AFUA_5G11020 ammonium transporter 4.3 Oxidoreductase activity, GO:0016491 P =0.04 AFUA_8G00480 2 phytanoyl-CoA dioxygenase family protein 41.9 AFUA_8G00560 2 cytochrome P450,...”
- The temporal dynamics of differential gene expression in Aspergillus fumigatus interacting with human immature dendritic cells in vitro
Morton, PloS one 2011 - “...dehydrogenase AFUA_4G00610 aryl-alcohol dehydrogenase AFUA_3G11430 Arginase AFUA_5G14330 12-oxophytodienoate reductase Oxidation of fatty acids (p: 0.054) AFUA_6G03060 MFS monosaccharide transporter AFUA_1G14540 oxidoreductase, short-chain dehydrogenase/reductase family AFUA_2G04060 NADHflavin oxidoreductase AFUA_5G09400 carbonyl reductase AFUA_2G01440 mitochondrial carrier protein AFUA_3G03410 enoyl-CoA hydratase/isomerase family protein AFUA_1G04720 C-8 sterol isomerase (Erg-1) Disease, virulence...”
- “...AFUA_3G01580 GMC oxidoreductase AFUA_5G14660 GABA permease AFUA_4G00610 aryl-alcohol dehydrogenase AFUA_6G00630 MFS transporter AFUA_5G14330 12-oxophytodienoate reductase AFUA_6G03060 MFS monosaccharide transporter AFUA_2G04060 NADHflavin oxidoreductase AFUA_4G00830 MFS peptide transporter Lipid/fatty acid transport (p: 0.089) Transport facilities (p: 0.078) AFUA_2G01440 mitochondrial carrier protein AFUA_6G00630 MFS transporter AFUA_1G04720 C-8 sterol isomerase...”
- Exploring temporal transcription regulation structure of Aspergillus fumigatus in heat shock by state space model
Do, BMC genomics 2009 - “...Copper amine oxidase, putative AFU4G12010 2-oxoacid dehydrogenases acyltransferase, putative 2(+) AFU6G03730 2-methyl citrate dehydratase, putative AFU6G03060 MFS monosaccharide transporter, putative 2(+) AFU6G02860 Isocitratelyase AFU6G03730 2-methylcitrate dehydratase, putative 2(+) AFU4G11310 Fructose-1,6-bisphosphatase Fbp1, putative AFU6G02860 Isocitrate lyase 2(+) AFU7G01000 Aldehyde dehydrogenase, putative AFU3G01450 3-methyl-2-oxobutanoate dehydrogenase, putative 2(+) AFU6G14200...”
- Sub-telomere directed gene expression during initiation of invasive aspergillosis
McDonagh, PLoS pathogens 2008 - “...extracellular signalling protein (factor C) 3.0355716 Afu3g03240 MFS monocarboxylate transporter 4.628176816 Afu8g01130 alpha-galactosidase C 2.8084929 Afu6g03060 monosaccharide transporter 4.576610248 Afu4g01070 acid phosphatase 3.4709519 Afu5g01160 monosaccharide transporter 4.53846138 Afu7g05610 glucanase 3.7652613 Afu4g13080 monosaccharide transporter 4.316438927 Afu4g00870 antigenic cell wall galactomannoprotein 2.8100298 Afu7g05830 MFS sugar transporter 4.069715654 Afu6g02980...”
SS1G_13734 hypothetical protein from Sclerotinia sclerotiorum 1980 UF-70
42% identity, 62% coverage
Q6BW54 DEHA2B14278p from Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)
32% identity, 63% coverage
SS1G_06620 hypothetical protein from Sclerotinia sclerotiorum 1980 UF-70
34% identity, 81% coverage
CNAG_03772 glucose transporter from Cryptococcus neoformans var. grubii H99
32% identity, 91% coverage
- The Dynamics of Cryptococcus neoformans Cell and Transcriptional Remodeling during Infection
Freitas, Cells 2022 - “...the host from the pre-culture in a rich medium (YPD). We did note increased HXS1 (CNAG_03772) transcripts at the early stage, and this high-affinity glucose transporter is regulated by glucose and involved in fungal virulence [ 64 ]. In this context, the level of glucose in...”
- Identification of Pathogen Genomic Differences That Impact Human Immune Response and Disease during Cryptococcus neoformans Infection
Gerstein, mBio 2019 - “...following genes of known function: LIV11 (CNAG_05422), encoding a virulence protein of unknown function; HSX1 (CNAG_03772), encoding a high-affinity glucose transporter; PTP2 (CNAG_05155), encoding a protein tyrosine phosphatase; and SPT8 (CNAG_06597), encoding a predicted saga histone acetyltransferase complex component. FIG4 Clade-specific variants. (A) Variants that are...”
- Investigation of Cryptococcus neoformans magnesium transporters reveals important role of vacuolar magnesium transporter in regulating fungal virulence factors
Suo, MicrobiologyOpen 2018 - “...Mg v H99) b Description CNAG_03502 4.28 3.44 Magnesium transporter CNAG_02489 1.20 2.37 Alcohol dehydrogenase CNAG_03772 0.92 2.28 Glucose transporter CNAG_07788 1.62 1.98 Unknown CNAG_05212 2.08 1.72 Unknown CNAG_07819 1.33 1.64 Unknown CNAG_05487 1.65 1.61 Unknown CNAG_07845 1.84 1.41 Unknown CNAG_05874 1.55 1.20 Unknown CNAG_00679 1.32...”
- “...an extremely important regulator of C. neoformans virulence. Interestingly, the expression of the glucose transporter (CNAG_03772) is repressed when Mgt2 expression is inhibited. It is likely that the mgt2 mutant activates the cAMPPKA pathway via intracellular glucose deficiency, which in turns, causes capsule structure induction and...”
- Galectin-3 impacts Cryptococcus neoformans infection through direct antifungal effects
Almeida, Nature communications 2017 - “...XM_012191495.1 4.66 0.0407 1.3 33.0 CNAG_00680 Kinetochore protein Nuf2, variant XM_012191826.1 4.39 0.0000 3.9 81.8 CNAG_03772 Glucose transporter XM_012191299.1 4.17 0.0000 6.9 126.2 CNAG_00393 1,4-alpha-glucan-branching enzyme XM_012198536.1 3.82 0.0000 1.2 16.8 CNAG_07874 Sugar transporter XM_012196714.1 3.81 0.0000 12.0 170.1 CNAG_04621 Glycogen(starch) synthase, variant XM_012192450.1 3.58 0.0000...”
- Transmembrane transporter expression regulated by the glucosylceramide pathway in Cryptococcus neoformans
Singh, BMC research notes 2015 - “...All the six genes we identified, viz siderochrome-iron transporter (CNAG_02083), monosaccharide transporter (CNAG_05340), glucose transporter (CNAG_03772), membrane protein (CNAG_03912), membrane transport protein (CNAG_00539), and sugar transporter (CNAG_06963), are membrane-localized and have significantly altered gene expression levels. Therefore, we hypothesize that these genes function either independently or...”
- “...5-ACGCCGATGGATTATTACTAGC-3, reverse: 5-CGACCTAGCAGTTCCGAAAG-3; CNAG_06963 (Sugar-transporter), forward: 5-TGGTCCTATCGGTGACTACTCT-3, reverse: 5-GCCAACTTGAGACACAAGCA-3; CNAG_05340 (Monosaccharide-transporter), forward: 5-AGGGATCGTTAGCTTTTGGTATG-3, reverse: 5-GGAAAATTGTTCGAGGACGA-3; CNAG_03772 (Glucose-transporter), forward: 5-GGACTGGTGTCAACTTCATTTTC-3, reverse: 5-CGACACCAATGATACCGACA-3; CNAG_00334 (Heat-shock-protein), forward: 5-GAGTCGAGATCATCGCCAAC-3, reverse: 5-TTAACGTCAGCGTCGTCGTA-3; CNAG_03780 (Prcdna95), forward: 5-AAGGGTGTCGTTGCCTTCTAC-3, reverse: 5-ATAGCCAAAACCCTCCATCC-3; CNAG_00092 (Mitochondrial-protein), forward: 5-GACCCAAGACCATCTTCTTCT-3, reverse: 5-GCAGCGAGGGAGTAGTTGAC-3; CNAG_01307 (Endoplasmic-reticulum-protein), forward: 5-AGCGAAACTTGTACTTGACAGG-3, reverse: 5-GCCATACTCGGCATTCTGTT-3; CNAG_01150...”
- Rapid mapping of insertional mutations to probe cell wall regulation in Cryptococcus neoformans
Esher, Fungal genetics and biology : FG & B 2015 - “...Singleton -- Chromosome 1 1752283-1752786 45 Promoter Pair CNAG_00674 Chromosome 2 774969-775175 15 CDS Singleton CNAG_03772 Chromosome 2 991283-991766 10 CDS Pair CNAG_03844 Chromosome 3 596973-597253 12 CDS Pair CNAG_02857 Chromosome 3 754720-754915 10 CDS Pair CNAG_02793 Chromosome 3 1050456-1050652 19 CDS Pair CNAG_02676 Chromosome 3...”
- The glucose sensor-like protein Hxs1 is a high-affinity glucose transporter and required for virulence in Cryptococcus neoformans
Liu, PloS one 2013 - “...12 transmembrane domains, a typical structure of hexose transporters ( Fig. 1B ). Both Hxs1 (CNAG_03772; 553 amino acids) and Hxs2 (CNAG_04931; 428 amino acids) are much smaller than Snf3 or Rgt2 in S. cerevisiae. Interestingly, neither of them has the long C-terminal tail and the...”
- The transcriptional response of Cryptococcus neoformans to ingestion by Acanthamoeba castellanii and macrophages provides insights into the evolutionary adaptation to the mammalian host
Derengowski, Eukaryotic cell 2013 - “...Transport CNAG_07869 CNAG_05662 CNAG_01384 CNAG_01936 CNAG_03772 CNAG_03910 CNAG_03060 CNAG_01925 CNAG_05685 CNAG_05929 CNAG_02288 CNAG_07367 CNAG_04795...”
- More
CH_124126 hexose transporter 2 from Magnaporthe grisea 70-15 (see paper)
34% identity, 78% coverage
Pc21g21590 uncharacterized protein from Penicillium rubens
31% identity, 94% coverage
CNB02680 glucose transporter from Cryptococcus neoformans var. neoformans JEC21
32% identity, 91% coverage
- Pleiotropy and epistasis within and between signaling pathways defines the genetic architecture of fungal virulence
Roth, PLoS genetics 2021 - “...markers inserted at intergenic regions flanking the QTL. The chosen intergenic regions were between genes CNB02680 and CNB02690 at approximately 797,055797,281 kb on the left and between genes CNB03490 and CNB03500 at approximately 1,047,1381,047,346 kb on the right of the chromosome 2 QTL for the NAT...”
- “...QTL-L and QTL-R refer to intergenic regions on chromosome 2 at 797,055797,281 bp, between genes CNB02680 and CNB02690 and at 1,047,1381,047,346 bp, between genes CNB03490 and CNB03500 , respectively in the XL280 a strain background [ 211 ]. (PDF) Click here for additional data file. S2...”
- Cryptococcus neoformans mediator protein Ssn8 negatively regulates diverse physiological processes and is required for virulence
Wang, PloS one 2011 - “...data not shown). In addition, we also examined the expressions of HXT (a hexose transporter, CNB02680) and SNF1 in the C. neoformans MAT strains including three ssn8 mutants in YPD liquid medium. Elevated transcript levels of these genes were detected in the mutants ( Table S1...”
- Metabolic adaptation in Cryptococcus neoformans during early murine pulmonary infection
Hu, Molecular microbiology 2008 - “...25 CND01120 XM_570351 fatty acid beta-oxidation- related protein Transporters TATACGATTT 26 0 612 143 2 CNB02680 XM_568855 monosaccharide transporter, HXT1 CCCATCGTAT 82 0 136 79 24 CNM02430 XM_568258 plasma membrane iron permease, CFT1 CTTGACAGCG 0 5 42 46 0 CNF02960 XM_571371 acetate transporter, ADY2 TATCTGATTT 19...”
- Identification of Cryptococcus neoformans temperature-regulated genes with a genomic-DNA microarray
Kraus, Eukaryotic cell 2004 - “...2.8 2.8 2.7 2.7 2.7 2.5 2.2 LYS2 CNB02680 CND03740 CNF00610 CNJ00670 CNG03520 CNG04460 CNG01070 CNG03440 CNG04330 PAK1 CNG01610 CNM01490 CNG02710 MDR1 CNG01350...”
CNAG_04931 hypothetical protein from Cryptococcus neoformans var. grubii H99
34% identity, 79% coverage
AO090003001556 No description from Aspergillus oryzae RIB40
31% identity, 96% coverage
hxtA high-affinity hexose transporter from Emericella nidulans (see paper)
32% identity, 93% coverage
- CharProtDB Description: Putative high-affinity hexose transporter with a predicted role in hexose transport; induced upon starvation and during sexual development; Source:Eurofung
NCU06358 high affinity glucose transporter RGT2 from Neurospora crassa OR74A
30% identity, 81% coverage
- Correlating sugar transporter expression and activities to identify transporters for an orphan sugar substrate
Tamayo, Applied microbiology and biotechnology 2024 - “...d -mannose, putative monosaccharide transporters from cluster 1 (like XYT-1, FRT-1, HGT-2, NCU04537, HGT-1, QaY, NCU06358, GLT-1, NCU06384, and NCU06138) could be potential candidates, but likely also only by contributing with unspecific side activities. Lactose uptake assays of transporter candidates Following the previous global analyses of...”
- Identification and characterization of the glucose dual-affinity transport system in Neurospora crassa: pleiotropic roles in nutrient transport, signaling, and carbon catabolite repression
Wang, Biotechnology for biofuels 2017 - “...presence of adequate glucose (0.5%; Fig. 4 d). Some other putative sugar transporters, such as NCU06358 and xyt - 1 (Fig. 4 d), were synchronously induced, indicating they have redundant roles in glucose uptake. In contrast, no significant increase in glt - 1 expression was found...”
- “...resulting in synergistically elevated expression (ten- to 30-fold) of hgt - 1/ - 2 and NCU06358 (Additional file 14 : Figure S9). Because the derepression of high-affinity glucose transporters hgt - 1/ - 2 was not affected in the rco - 3 mutant, RCO-3 might act...”
- Transcriptional comparison of the filamentous fungus Neurospora crassa growing on three major monosaccharides D-glucose, D-xylose and L-arabinose
Li, Biotechnology for biofuels 2014 - “...10.25 0.55 NCU05585 MFS quinate transporter 1.01 47.89 1.52 NCU06026 Quinate permease 5.99 37.83 13.25 NCU06358 High affinity glucose transporter RGT2 1.71 51.82 18.50 NCU06384 MFS sugar transporter 0.08 2.88 1.11 NCU06522 MFS maltose permease 1.35 3.39 1.98 NCU07054 Sugar transporter 4 0.03 0.41 0.14 NCU07169...”
- Deciphering transcriptional regulatory mechanisms associated with hemicellulose degradation in Neurospora crassa
Sun, Eukaryotic cell 2012 - “...NCU02188, NCU02238, NCU02582, NCU05853, NCU06138, NCU06305, NCU06358, NCU08114, and NCU09027). In addition, 6 pentose-phosphate pathway (PPP) genes (NCU01328,...”
FVEG_01638 hypothetical protein from Fusarium verticillioides 7600
32% identity, 83% coverage
CNBG_0170 glucose transporter from Cryptococcus deuterogattii R265
33% identity, 87% coverage
MF127_ASPFN / B8MYS7 MFS glucose transporter mfs1; Asparasone A synthesis protein mfs1 from Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167) (see paper)
31% identity, 98% coverage
- function: Probable MFS glucose transporter; part of the gene cluster 27 that mediates the biosynthesis of asparasone A, a sclerotium-specific anthraquinone pigment important for sclerotial survival (PubMed:24412484).
CNBG_5746 galactose transporter from Cryptococcus deuterogattii R265
33% identity, 87% coverage
- Identification and Characterization of an Intergenic "Safe Haven" Region in Human Fungal Pathogen Cryptococcus gattii
Li, Journal of fungi (Basel, Switzerland) 2022 - “...and CNBG_5898 on chromosome 4; and Candidate 3the 4073 bp intergenic region between CNBG_5745 and CNBG_5746 on chromosome 4. 3.2. Insertion of Foreign DNA into the Candidate 1 or the Candidate 2 Site Has No Significant Impact on the Expression of the Neighboring Genes Our selection...”
- “...CNBG_5897 and CNBG_5898 in the two selected transformants for candidate 2, and of CNBG_5745 and CNBG_5746 in the two selected transformants for candidate 3. The transcript level of CNBG_3433 and CNBG_3434 in the selected transformants for candidate 1 site showed no apparent difference compared to those...”
PODANS_1_22840 uncharacterized protein from Podospora anserina S mat+
31% identity, 92% coverage
CNAG_05387 galactose transporter from Cryptococcus neoformans var. grubii H99
32% identity, 87% coverage
- Antifungal activity of eumelanin-inspired indoylenepheyleneethynylene against <i>Cryptococcus neoformans</i>
Conn, Frontiers in microbiology 2023 - “...Gene ID Gene name Log2foldChange p -adjusted Gene description CNAG_01683 STL1 2.362044974 0* Sugar transporter CNAG_05387 1.891607373 0* MFS glucose transporter mfs1 CNAG_01577 2.794167594 0* NADP-specific glutamate dehydrogenase CNAG_06150 2.515378205 0* Heat shock protein 902 CNAG_04630 YAP2 1.495267376 0* Hypothetical protein CNAG_01750 1.7658259 0* Heat shock...”
- A PAS Protein Directs Metabolic Reprogramming during Cryptococcal Adaptation to Hypoxia
Zhao, mBio 2021 - “...of Pas2 in regulating hypoxia-induced metabolic reprogramming. For instance, the genes involved in glycolysis ( CNAG_05387 and CNAG_06290 ), fermentation ( CNAG_01955 , CNAG_04659 , and CNAG_07745 ), gluconeogenesis ( CNAG_04217 ), the PPP ( CNAG_04025 and CNAG_06923 ), and the TCA cycle ( CNAG_06374 )...”
- Galectin-3 impacts Cryptococcus neoformans infection through direct antifungal effects
Almeida, Nature communications 2017 - “...Atg18 XM_012191442.1 3.12 0.0000 2.4 21.4 CNAG_00598 Nicotinamide mononucleotide permease XM_012198344.1 2.87 0.0000 281.5 2069.0 CNAG_05387 Galactose transporter XM_012191781.1 2.84 0.0000 3.5 25.2 CNAG_03666 Acyl-CoA dehydrogenase XM_012193765.1 2.82 0.0001 0.5 3.3 CNAG_00865 Maltose O -acetyltransferase partial XM_012192132.1 2.80 0.0000 8.7 61.1 CNAG_03876 Ras family protein XM_012194860.1...”
- The glucose sensor-like protein Hxs1 is a high-affinity glucose transporter and required for virulence in Cryptococcus neoformans
Liu, PloS one 2013 - “...HXT1 . Meanwhile, HXT2 (CNAG_06290) was induced only by the high glucose concentration, while HXT3 (CNAG_05387) was induced only by low glucose condition ( Fig. 3 ). The changes of transcription level of other tested HXT homologs, HXT4 (CNAG_06521), HXT6 (CNAG_06963) and HXT7 (CNAG_03432), were not...”
NCU06138 quinate permease from Neurospora crassa OR74A
28% identity, 89% coverage
- Correlating sugar transporter expression and activities to identify transporters for an orphan sugar substrate
Tamayo, Applied microbiology and biotechnology 2024 - “...transporters from cluster 1 (like XYT-1, FRT-1, HGT-2, NCU04537, HGT-1, QaY, NCU06358, GLT-1, NCU06384, and NCU06138) could be potential candidates, but likely also only by contributing with unspecific side activities. Lactose uptake assays of transporter candidates Following the previous global analyses of the sugar transportome of...”
- Independent metabolism of oligosaccharides is the keystone of synchronous utilization of cellulose and hemicellulose in Myceliophthora
Liu, PNAS nexus 2024 - “...xylose transporter Mycth_96047, with a high identity with the xylose and glucose transporter encoded by NCU06138 in N. crassa ( 40 ), showed a high expression level under xylose, xylobiose, and xylan conditions, while it was strongly inhibited by glucose (Fig. 4 C). Additionally, the expression...”
- The transcription factor PDR-1 is a multi-functional regulator and key component of pectin deconstruction and catabolism in Neurospora crassa
Thieme, Biotechnology for biofuels 2017 - “...(NCU04130), the glycerol-3-phosphate O -acyltransferase chol - 6 (NCU05985), the quinate permease mfs - 19 (NCU06138), the endo-1,4--xylanase gh11 - 2 (NCU07225), the fumarylacetoacetate hydrolase fah - 2 (NCU07506), the mitochondrial triosephosphate isomerase emp - 19 (NCU10106), a glyoxalase (NCU11253), and four hypothetical proteins (NCU01700, NCU01871,...”
- “...2 1 C13 NCU05037 put . lra4 4 C1 NCU05985 chol - 6 1 C1 NCU06138 mfs - 19 1 C13 NCU07225 gh11 - 2 1 C13 NCU07506 fah - 2 3 C1 NCU08475 Hypothetical protein 2 C1 NCU09033 pdr - 1 5 C1 NCU09034 put....”
- Direct target network of the Neurospora crassa plant cell wall deconstruction regulators CLR-1, CLR-2, and XLR-1
Craig, mBio 2015 - “...1 Acetyl xylan esterase NCU05159 ce5 - 2 Acetyl xylan esterase NCU05350 Major facilitator transporter NCU06138 xy-31 Xylose transporter NCU06143 gh115-1 Putative glucuronidase NCU06490 Hypothetical protein NCU07225 a gh11-2 Endo-1,4--xylanase NCU07510 Hypothetical protein NCU08114 a cdt-2 Cellodextrin/xylodextrin transporter NCU08189 gh10-2 Endo-1,4--xylanase NCU08384 xyr-1 Xylose reductase NCU09652...”
- Transcriptional comparison of the filamentous fungus Neurospora crassa growing on three major monosaccharides D-glucose, D-xylose and L-arabinose
Li, Biotechnology for biofuels 2014 - “...1045.02 NCU00809 MFS monosaccharide transporter 7.07 314.73 6.64 NCU01132 MFS monosaccharide transporter 0.46 280.94 0.87 NCU06138 Quinate permease 0.74 213.95 75.43 NCU05897 L-fucose permease 1.10 179.47 315.45 NCU05853 MFS sugar transporter 2.36 149.95 5.65 NCU04963 High-affinity glucose transporter 4.91 128.69 402.90 NCU04537 Monosaccharide transporter 1.06 3.35...”
- “...well-characterized so far, although limited analysis has been performed on five of them; NCU04963 and NCU06138 have the capability to transport both xylose and glucose, whereas very weak xylose transportation activity was detected in a recombinant yeast strain harboring NCU02188, NCU04537 or NCU09287 [ 9 ]....”
- Deciphering transcriptional regulatory mechanisms associated with hemicellulose degradation in Neurospora crassa
Sun, Eukaryotic cell 2012 - “...(NCU00988, NCU01132, NCU02188, NCU02238, NCU02582, NCU05853, NCU06138, NCU06305, NCU06358, NCU08114, and NCU09027). In addition, 6 pentose-phosphate pathway...”
- “...NCU09652, -xylosidase, gh43-5), and two transporter genes (NCU06138 and NCU08114). Other genes encode proteins with a potential role in hemicellulose...”
- Systems analysis of plant cell wall degradation by the model filamentous fungus Neurospora crassa
Tian, Proceedings of the National Academy of Sciences of the United States of America 2009 - “...(NCU00801, NCU00988, NCU01231, NCU04963, NCU05519, NCU05853, NCU05897, NCU06138, NCU08114, and NCU10021) and 23 putative or hypothetical proteins. Of the 117...”
Afu3g14170 MFS glucose transporter, putative from Aspergillus fumigatus Af293
31% identity, 93% coverage
- Transcriptomic and proteomic analyses of the Aspergillus fumigatus hypoxia response using an oxygen-controlled fermenter
Barker, BMC genomics 2012 - “...associated with a KEGG pathway. Some of these transcripts were verified with RT-PCR. For example, Afu3g14170 ( hxtA ), a major facilitator superfamily glucose transporter and putative high-affinity hexose transporter, was up at all time points (Figure 11A ). The homolog in A. nidulans is associated...”
- “...hexokinase HxtA. Figure 11 RT-PCR of novel transcripts affected by hypoxia . A. Four transcripts (Afu3g14170 ( hxtA ), Afu2g09590 ( udpA ), Afu3g11590 ( atg11 ), Afu5g00900 ( rgsA )) that were significantly increased using real time RT-PCR. B. Three transcripts (Afu5g12510 ( afeA ),...”
E6RCH7 High-affinity glucose transporter of the major facilitator superfamily, putative Hxt4p from Cryptococcus gattii serotype B (strain WM276 / ATCC MYA-4071)
32% identity, 86% coverage
- Phenotypic characteristics and transcriptome profile of Cryptococcus gattii biofilm
Tavares, Scientific reports 2019 - “...process Ergosterol biosynthetic process CGB_J0030W 4,798 ADV24539 High-affinity glucose transporter of the major facilitator superfamily E6RCH7 High-affinity glucose transporter of the major facilitator superfamily Transmembrane transport CGB_F0090C 14,363 ADV22816 Monocarboxylic acid transporter E6R7J0 Monocarboxylic acid transporter Transmembrane transport Ion transmembrane transport CGB_M2010W 9,461 ADV25506 dUTP diphosphatase...”
XP_042994317 uncharacterized protein from Ustilaginoidea virens
33% identity, 83% coverage
An06g00560 uncharacterized protein from Aspergillus niger
31% identity, 90% coverage
- In Silico Analysis of Putative Sugar Transporter Genes in Aspergillus niger Using Phylogeny and Comparative Transcriptomics
Peng, Frontiers in microbiology 2018 - “...(An14g04280) ( Sloothaak et al., 2014 ) and the D -xylose transporter encoding gene xltA (An06g00560) ( Sloothaak et al., 2016b ) were also clearly induced by their corresponding sugars. Interestingly, several transporters lacking solid experimental proof of function also had highly specific expression profiles. For...”
- “...et al., 2013 ), in which An03g01620 and An08g01720 were also affected by AraR, while An06g00560 ( xltA ) was under control of XlnR. While some of the transporters appear to be under control of the same regulators (e.g., XlnR, AmyR, and RhaR) that control polysaccharide...”
- Construction of an improved Aspergillus niger platform for enhanced glucoamylase secretion
Fiedler, Microbial cell factories 2018 - “...metabolism and calcium signalling, also four genes supposedly related to carbon catabolism were differentially expressed: An06g00560 (ortholog of the Saccharomyces cerevisiae Hxt13p hexose transporter) and An12g00160 (ortholog of the Saccharomyces cerevisiae Mae1 malic enzyme) were both up-regulated, whereas An16g01770 (predicted xylose reductase) and An07g01340 (predicted phosphoenolpyruvate...”
- RNA-sequencing reveals the complexities of the transcriptional response to lignocellulosic biofuel substrates in Aspergillus niger
Pullan, Fungal biology and biotechnology 2014 - “...38.20 1.72 676.84 <0.01 TID_38375 An08g04040 transmembrane transporter activity 0.53 7.98 0.84 32.31 <0.01 TID_55668 An06g00560 transmembrane transporter activity 0.19 24.08 0.30 263.55 <0.01 TID_180069 An07g02540 transmembrane transporter activity 0.10 2.05 0.75 43.05 <0.01 TID_197549 An02g08230 transmembrane transporter activity 0.26 18.83 0.09 146.66 <0.01 TID_54095 An18g01700...”
- The transcriptomic signature of RacA activation and inactivation provides new insights into the morphogenetic network of Aspergillus niger
Kwon, PloS one 2013 - “...permease An18g01220 Dal5 oligopeptide transporter An13g01760 Opt1 An15g07460 Opt1 oligopeptide transporter An11g01040 Opt1 hexose/glucose transporter An06g00560 Hxt13 An09g04810 amino acid transporter An03g00430 galactose transporter An01g10970 Gal2 FAD transporter into endoplasmatic reticulum, CWI-related An01g09050 Flc2 Protein trafficking GTPase activating protein involved in protein trafficking An01g02860 Gyp8 An15g01560...”
- Uncovering the genome-wide transcriptional responses of the filamentous fungus Aspergillus niger to lignocellulose using RNA sequencing
Delmas, PLoS genetics 2012 - “...38375 An08g04040 Similarity to quinate transport protein QutD - Aspergillus nidulans 1.7 141.9 2.9 55668 An06g00560 Similarity to hexose transporter Hxt13 - Saccharomyces cerevisiae 0.6 124.0 3.7 180069 An07g02540 Similarity to carboxylic acid transport protein Jen1 - Saccharomyces cerevisiae 1.5 108.6 2.0 197549 An02g08230 Similarity to...”
- Analysis of variance components reveals the contribution of sample processing to transcript variation
van, Applied and environmental microbiology 2009 - “...An09g03300 An03g00500 An15g01500 An11g01100 An03g01620 An06g00560 An01g10920 An01g03740 An12g00030 An07g03140 An02g03590 Signal sequence predicted Yes Yes...”
XP_026623817 general substrate transporter from Aspergillus welwitschiae
31% identity, 89% coverage
- Advances in fungal sugar transporters: unlocking the potential of second-generation bioethanol production
Pereira, Applied microbiology and biotechnology 2025 - “...Glucose, fructose, galactose, mannose, and sucrose A. niger Sloothaak et al. ( 2015 ) XltA XP_026623817 Glucose, xylose, galactose, and mannose A. niger Sloothaak et al. ( 2016b ) MstC/HxtB Q5AYG1 Glucose, xylose, fructose, galactose, and mannose A. nidulans dos Reis et al. ( 2013 );...”
MAA_02398 monosaccharide transporter from Metarhizium robertsii ARSEF 23
32% identity, 83% coverage
- The Sugar Transporter MST1 Is Involved in Colonization of Rhizosphere and Rhizoplane by Metarhizium robertsii
Dai, mSystems 2021 - “...In our previous RNA-Seq analysis ( 13 , 14 ), we noticed that a gene (MAA_02398) was highly expressed during symbiotic growth on Arabidopsis thaliana roots, saprophytic growth in nutrient-rich SDY medium (Sabouraud dextrose broth supplemented with 1% yeast extract), and infection of insects. MAA_02398 is...”
- “...acids, which has 12 transmembrane domains as predicted by TMHMM version 2.0 ( 15 ). MAA_02398 is designated MST1 as it is a m ono s accharide t ransporter (see below). BLASTP analysis showed that homologs of MST1 were widely found in many plant-associated fungi such...”
PODANS_4_9820 uncharacterized protein from Podospora anserina S mat+
31% identity, 86% coverage
CNAG_06521 hypothetical protein from Cryptococcus neoformans var. grubii H99
31% identity, 87% coverage
G0RIJ1 Predicted protein from Hypocrea jecorina (strain QM6a)
33% identity, 83% coverage
CH_124119 high-affinity glucose transporter from Magnaporthe grisea 70-15 (see paper)
28% identity, 90% coverage
PODANS_5_480 uncharacterized protein from Podospora anserina S mat+
32% identity, 83% coverage
Afu2g05190 MFS monosaccharide transporter, putative from Aspergillus fumigatus Af293
30% identity, 89% coverage
- Evolutionary Analysis of Sequence Divergence and Diversity of Duplicate Genes in Aspergillus fumigatus
Yang, Evolutionary bioinformatics online 2012 - “...1.43 [0.77, 2.58] Afu1g16080 2.53 [0.27, 3.04] Afu5g14990 2.78 [2.06, 0.45] Afu5g00280 2.43 [0.27, 2.94] Afu2g05190 0.61 [1.22, 2.18] Afu7g01690 2.41 [0.35, 3.07] Afu8g05220 2.61 [2.09, 0.65] Afu3g00670 2.39 [0.59, 3.44] Afu5g13060 2.60 [2.05, 0.60] Afu6g12820 2.37 [2.06, 6.42] Afu2g12200 0.65 [1.79, 1.77] Afu6g02420 2.35 [2.02,...”
TC 2.A.1.1.119 / A2R3H2 The galacturonic acid (galacturonate) uptake porter, GatA, of 518 aas and 12 TMSs from Aspergillus niger (strain CBS 513.88 / FGSC A1513)
An14g04280 uncharacterized protein from Aspergillus niger
30% identity, 92% coverage
- substrates: Galacturonate
- In Silico Analysis of Putative Sugar Transporter Genes in Aspergillus niger Using Phylogeny and Comparative Transcriptomics
Peng, Frontiers in microbiology 2018 - “...expressed on hexose substrates than other monosaccharides. The D -galacturonic acid transporter encoding genes gatA (An14g04280) ( Sloothaak et al., 2014 ) and the D -xylose transporter encoding gene xltA (An06g00560) ( Sloothaak et al., 2016b ) were also clearly induced by their corresponding sugars. Interestingly,...”
- Engineering Saccharomyces cerevisiae for co-utilization of D-galacturonic acid and D-glucose from citrus peel waste
Protzko, Nature communications 2018 - “...these transporters, we additionally incubated cultures at pH 3.5 (Supplementary Fig. 7 ). We identified An14g04280, or GatA 36 , from A. niger as a transporter that allowed for 11.9g/L consumption of d -galUA at high pH in our catabolic strain during the course of the...”
- Inducer-independent production of pectinases in Aspergillus niger by overexpression of the D-galacturonic acid-responsive transcription factor gaaR
Alazi, Applied microbiology and biotechnology 2018 - “...#N/A #N/A #N/A NRRL3_10115 An11g00390 rhamnogalacturonan lyase PL4_3 0.648 0.810 11.176 #N/A #N/A #N/A NRRL3_00958 An14g04280 MFS-type sugar/inositol transporter GatA 3.472 524.952* 125.820* #N/A #N/A #N/A NRRL3_08663 An03g01620 MFS-type sugar/inositol transporter 0.274 5.622* 0.577 #N/A #N/A #N/A NRRL3_04281 An07g00780 MFS-type transporter 3.110 4.596 13.958* #N/A #N/A...”
- The pathway intermediate 2-keto-3-deoxy-L-galactonate mediates the induction of genes involved in D-galacturonic acid utilization in Aspergillus niger
Alazi, FEBS letters 2017 - “...Gene ID CBS513.88 Description a Gene name Ref gaaC FC gaaC /Ref P value NRRL3_00958 An14g04280 d galacturonic acid transporter GatA gatA 888.35 1062.68 1.20 6.95E02 NRRL3_03144 An12g07500 Exopolygalacturonase 698.90 3384.63 4.84 1.34E02 NRRL3_05260 An02g12450 Exopolygalacturonase Pgx28C pgx28C 99.93 192.85 1.93 9.11E02 NRRL3_05649 An02g07720 2Keto3deoxy l...”
- The transcriptional activator GaaR of Aspergillus niger is required for release and utilization of d-galacturonic acid from pectin
Alazi, FEBS letters 2016 - “...gaaR GA 2h Fold change Ref/ gaaR GA 2h P value GARE (CCNCCAA) position NRRL3_00958 An14g04280 gatA a 888.35 13.32 66.69 1.54E03 +strand 360 NRRL3_08663 An03g01620 GA transporter (putative) a 106.09 30.34 3.50 1.25E01 +strand 673 NRRL3_04281 An07g00780 GA transporter (putative) a 90.41 1.86 48.74 7.77E03...”
- “...Ref SBP 24h gaaR SBP 24h Fold change Ref/ gaaR SBP 24h P value NRRL3_00958 An14g04280 gatA a 849.85 12.60 67.45 6.18E05 1077.70 21.92 49.17 2.84E03 57.92 1.82 31.91 5.06E02 NRRL3_08663 An03g01620 GA transporter (putative) a 2647.36 642.68 4.12 1.01E04 387.81 273.28 1.42 2.41E01 2.69 3.20...”
- Overexpression of the Aspergillus niger GatA transporter leads to preferential use of D-galacturonic acid over D-xylose
Sloothaak, AMB Express 2014 - “...to use this transporter to study D-galacturonic acid metabolism. We have functionally characterized the gene An14g04280 that encodes the D-galacturonic acid transporter in A. niger. In a mixed sugar fermentation it was found that the An14g04280 overexpression strain, in contrast to the parent control strain, has...”
- “...galA poly-galA pectin An07g00780 Major facilitator superfamily strong similarity to monocarboxylate transporter 23.10 9.98 5.27 An14g04280 Major facilitator superfamily strong similarity to hexose transporter 26.53 22.74 27.95 An03g01620 Major facilitator superfamily strong similarity to hexose transporter 6.50 1.345 37.54 In this study we have functionally identified...”
- Conversion of orange peel to L-galactonic acid in a consolidated process using engineered strains of Aspergillus niger
Kuivanen, AMB Express 2014 - “...green I master mix and the LightCycler 96 System. The transcription of putative D-galacturonate transporters An14g04280 and An03g01620 (Martens-Uzunova and Schaap [ 2008 ]) was quantified with the primers listed previously (Kuivanen et al. [ 2012 ]). The transcription levels were normalized to actin using the...”
- “...transport of the substrate into the cell, the transcription of two putative D-galacturonic acid transporters, An14g04280 and An03g01620, was followed by qPCR in the SmFs carried out with gaaB without the nutritional supplementation (Figure 4 ). The transcription of An14g04280 in gaaB did not show any...”
- Identification and characterization of a galacturonic acid transporter from Neurospora crassa and its application for Saccharomyces cerevisiae fermentation processes
Benz, Biotechnology for biofuels 2014 - “...Interestingly, Aspergillus niger only has a clade-2 homolog to GAT-1. However, since the corresponding gene (An14g04280) has been previously shown to be co-regulated with genes involved in pectin degradation and D-GalA catabolism and failed to express in absence of gaaB , the hypothesis of it being...”
- “...forward [ 25 , 45 ]. Additionally, Zhang et al . (2013) recently reported the An14g04280 homolog in Botrytis cinerea ( BcHxt15 ) to be specifically induced by D-GalA and the corresponding mutant to be impaired in growth on D-GalA, which led them to suggest that...”
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CNC03580 hexose transport-related protein from Cryptococcus neoformans var. neoformans JEC21
30% identity, 77% coverage
AO090010000488 No description from Aspergillus oryzae RIB40
30% identity, 84% coverage
CNAG_02733 monosaccharide transporter from Cryptococcus neoformans var. grubii H99
30% identity, 77% coverage
- Cryptococcus neoformans can form titan-like cells in vitro in response to multiple signals
Trevijano-Contador, PLoS pathogens 2018 - “...RNA polymerase II promoters. In the former category there were included diverse sugar transporters (CNAG_01862, CNAG_02733, CNAG_05662, CNAG_06292, and CNAG_06932), plus a likely glycerol proton symporter similar to budding yeast Stl1 (CNAG_04784). The latter category contained 14 putative transcription factors, most of them belonging to the...”
- “..., HXT13 ,. family) 0.3 0.2 4.7E-02 CNAG_02595 hypothetical protein, variant 0.1 2.7E-02 0.2 1.5E-02 CNAG_02733 hexose transporter ( STL1 , HXT8 , HXT13 ,. family) 0.3 0.0 6.9E-03 CNAG_02777 Pi transporter PHO84 0.4 0.5 1.4E-02 CNAG_04567 putative TPO-related spermine transporter 0.2 0.3 2.8E-02 CNAG_04597 hypothetical...”
An02g00590 uncharacterized protein from Aspergillus niger
30% identity, 92% coverage
MAA_02403 hexose transporter from Metarhizium robertsii ARSEF 23
28% identity, 89% coverage
- Carbon translocation from a plant to an insect-pathogenic endophytic fungus
Behie, Nature communications 2017 - “...MST2 during plant root colonization 25 . Metarhizium has three identified monosaccharide transporters (accession numbers: MAA_02403, MAA_03088, MAA_07773), and while these transporters have not been characterized in terms of specific function or location, BLAST analyses show sequence identities with sugar transporters in other root colonizing fungi...”
XP_001385583 sugar transporter, high affinity, putative from Scheffersomyces stipitis CBS 6054
A3LY10 Sugar transporter, high affinity, putative from Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)
30% identity, 90% coverage
- Genetic basis of the highly efficient yeast Kluyveromyces marxianus: complete genome sequence and transcriptome analyses
Lertwattanasakul, Biotechnology for biofuels 2015 - “...Dh_xylhp, AY347871; Ci_GXS1, GN107181; Ci_GXF1, GN107179; Ps_SUT1, XP_001387898; Ps_SUT2, XP_001384295; Ps_SUT3, XP_001386019; Ps_HXT2.4, XP_001387757; Ps_XUT1, XP_001385583; Ps_XUT2, XP_001387242; Ps_XUT3, XP_001387138; Ps_XUT4, XP_001386715; Ps_XUT5, XP_001385962; Ps_XUT6, XP_001386589; Ps_XUT7, XP_001387067; Ps_RGT2, XP_001386588; Ps_SLT1, XP_001383774; Kl_KHT1/RAG1, XP_453656; Kl_KHT2, GN107317; Kl_KHT3, XP_454897; Kl_FRT1, XP_454356; Kl_HGT1, XP_451484; Kl_HXT1, XP_455078; Kl_HXT14, XP_454897;...”
- Advances in fungal sugar transporters: unlocking the potential of second-generation bioethanol production
Pereira, Applied microbiology and biotechnology 2025 - “...Glucose, xylose, galactose, fructose, and mannose D. hansenii Young et al. ( 2011 ) XUT1 A3LY10 Glucose, xylose, D-arabinose, L-arabinose, galactose, fructose, and mannose S. stipitis Young et al. ( 2011 ); Watanabe et al. ( 2016 ) XUT3 A3GHU5 Glucose, xylose, D-arabinose, L-arabinose, galactose, fructose,...”
- Functional survey for heterologous sugar transport proteins, using Saccharomyces cerevisiae as a host
Young, Applied and environmental microbiology 2011 - “...Source or reference YOUNG ET AL. Y. lipolytica A3LY10 Q64L87 xylHP XUT1 B5RUJ3 DEHA2F19140 S. stipitis B5RSN0 DEHA2A14300 P0AGF4 Q6BW54 DEHA2B14278 xylE Q6BTD8...”
SS1G_07132 hypothetical protein from Sclerotinia sclerotiorum 1980 UF-70
29% identity, 81% coverage
Q7S0I5 MFS monosaccharide transporter from Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
NCU10021 MFS monosaccharide transporter from Neurospora crassa OR74A
32% identity, 83% coverage
- Advances in fungal sugar transporters: unlocking the potential of second-generation bioethanol production
Pereira, Applied microbiology and biotechnology 2025 - “...2017 ); Hassan et al. ( 2019 ); Havukainen et al. ( 2020 ) HGT-1 Q7S0I5 Glucose N. crassa Wang et al. ( 2017a ) HGT-2 Q7S3Q4 Glucose N. crassa Wang et al. ( 2017a ) GLT-1 Q1K4S3 Glucose and xylose N. crassa Li et al....”
- Do mitochondria use efflux pumps to protect their ribosomes from antibiotics?
Islam, Microbiology (Reading, England) 2023 - “...79 ] NCU09551 Q7S2B0 MFS G1UAY0, 2.3E^6 Q56ZZ7, 2.3E^7 Q8NBP5, 8.4E^9 [ 78 ] NCU10021 Q7S0I5 MFS Q8J2J7, 8.1E^102 Q9FMX3, 2.3E^55 Q96QE2, 2.8E^41 [ 78 ] *Information gathered from NCBI Protein BLAST, algorithm: PSI-BLAST ( https://www.ncbi.nlm.nih.gov/ ) and HMMER phmmer, Database: Reference Proteomes ( http://hmmer.org/ )...”
- Revisiting 2-Deoxyglucose Resistance in Neurospora crassa: Insights into Transcriptional Regulation of Hexose Transporters, Sugar Metabolism and Possible Modulation by Mating Type
Pandey, 2023 - Do mitochondria use efflux pumps to protect their ribosomes from antibiotics?
Islam, Microbiology (Reading, England) 2023 - “...[ 79 ] NCU09551 Q7S2B0 MFS G1UAY0, 2.3E^6 Q56ZZ7, 2.3E^7 Q8NBP5, 8.4E^9 [ 78 ] NCU10021 Q7S0I5 MFS Q8J2J7, 8.1E^102 Q9FMX3, 2.3E^55 Q96QE2, 2.8E^41 [ 78 ] *Information gathered from NCBI Protein BLAST, algorithm: PSI-BLAST ( https://www.ncbi.nlm.nih.gov/ ) and HMMER phmmer, Database: Reference Proteomes ( http://hmmer.org/...”
- Adaptation to glucose starvation is associated with molecular reorganization of the circadian clock in Neurospora crassa
Szőke, eLife 2023 - “...tetrahydroxynaphthalene reductase NCU08457 eas 49 73 n.s. hydrophobin NCU09873 acu-6 39 12 2.9 phosphoenolpyruvate carboxykinase NCU10021 hgt-1 35 56 1.4 monosacharide transporter NCU08755 gh3-3 28 38 n.s. beta-glucosidase NCU00762 gh5-1 21 n.s . n.s . endoglucanase NCU08114 cdt-2 21 11 n.s . hexose transporter Using the...”
- The F-box protein gene exo-1 is a target for reverse engineering enzyme hypersecretion in filamentous fungi
Gabriel, Proceedings of the National Academy of Sciences of the United States of America 2021 (secret) - Evaluating the circadian rhythm and response to glucose addition in dispersed growth cultures of Neurospora crassa
Kelliher, Fungal biology 2020 - “...as major components of System I: glt-1 (NCU01633), and of System II: hgt-1 and hgt-2 (NCU10021 and NCU04963) ( Wang et al., 2017 ). The K m values for all three transporters fall within the ranges of earlier work ( Wang et al., 2017 ). Gene...”
- The regulatory and transcriptional landscape associated with carbon utilization in a filamentous fungus
Wu, Proceedings of the National Academy of Sciences of the United States of America 2020 - “...transporter clade ( SI Appendix , Fig. S1 ), including one high-affinity glucose transporter, hgt-1 NCU10021 ( 35 ) and additional uncharacterized transporters (NCU00809, NCU06522, NCU09287, NCU04537, NCU01494, NCU06384, and NCU05897). An uncharacterized sugar transporter bound by CRE-1, sut-28 (NCU05897; annotated as a fucose permease; SI...”
- “...included NCU04537 (monosaccharide transporter), NCU04963 (high-affinity glucose transporter), NCU06026 (quinate permease), NCU05897 ( sut-28 ), NCU10021 ( hgt-1 ), NCU00821 (sugar transporter), and NCU05627 (high-affinity glucose transporter ght-1 ). The remaining set of 21 genes included a number of carbon metabolic enzymes and 5 genes encoding...”
- A fungal transcription factor essential for starch degradation affects integration of carbon and nitrogen metabolism
Xiong, PLoS genetics 2017 - “...cut-off value less than 1e-20 identified 14 genes likely encoding transporters. Four of them, hgt-1 (NCU10021), NCU05627, NCU04963, and NCU04537 are annotated as sugar transporter genes ( Fig 2C ). hgt-1 shows high affinity glucose transport activity [ 19 ], while NCU05627 ( xyt-1 ) has...”
- Identification and characterization of the glucose dual-affinity transport system in Neurospora crassa: pleiotropic roles in nutrient transport, signaling, and carbon catabolite repression
Wang, Biotechnology for biofuels 2017 - “...fungus N. crassa . One low-affinity glucose transporter, GLT-1 (NCU01633), and two high-affinity transporters, HGT-1/-2 (NCU10021 and NCU04963), were identified as the major components of systems I and II, respectively. Simultaneous deletion of hgt - 1/ - 2 (strain 2hgt ) resulted in a notable increase...”
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Afu1g03530 MFS sugar transporter, putative from Aspergillus fumigatus Af293
28% identity, 93% coverage
- Transcriptome and secretome analysis of Aspergillus fumigatus in the presence of sugarcane bagasse
de, BMC genomics 2018 - “...Database (AspGD; http://www.aspgd.org ) [ 32 ]. Three orthologous genes encoding possible putative xylose transporters (Afu1g03530, Afu4g14610, and Afu6g14442) and five related to cellobiose transporters (Afu3g01670, Afu6g14500, Afu6g14560, Afu7g05100, and Afu8g04480) have been identified in N. crassa , A. oryzae, A. niger , and A. nidulans...”
- “...xylose with an increase in up to 25-fold. On the other hand, the expression of Afu1g03530 increased to 250-, 180-, 25-, 60-, 200-, and 5-fold after 3, 6, 12, 18, 24, and 48h, respectively (Fig. 4b ). These results lead us to speculate that both genes...”
An15g04270 uncharacterized protein from Aspergillus niger
28% identity, 93% coverage
- In Silico Analysis of Putative Sugar Transporter Genes in Aspergillus niger Using Phylogeny and Comparative Transcriptomics
Peng, Frontiers in microbiology 2018 - “...fungal growth ( Vankuyk et al., 2004 ). In contrast, some transporters (An08g08520, An16g05750, An16g06610, An15g04270, and An14g01350 in Cluster C5 of Figure 3 ) were lowly expressed in most of the transcriptomes, which indicates a less important function under the tested conditions and sampling times....”
- Transcriptome analysis of Aspergillus niger grown on sugarcane bagasse
de, Biotechnology for biofuels 2011 - “...An12g09270 GGCTAA -356 1 Strong similarity to lactose permease ( lac12 ) 3.52 4.44 2.94 An15g04270 Strong similarity to quinate transport protein ( qutD ) 5.07 6.02 8.29 An15g05440 TTAGCC -6 -1 Strong similarity to high-affinity glucose transporter ( hgt1 ) 3.85 3.02 2.86 log 2...”
- “...2.49 0.08 3.02 0.32 0.094 0.019 An12g09270 0.96 0.08 23.40 3.50 4.28 0.64 3.17 0.61 An15g04270 0.036 0.004 0.037 0.006 0.13 0.02 0.110 0.009 An15g05440 0.021 0.004 0.071 0.002 0.041 0.007 0.003 0.001 SEB = steam-exploded sugarcane bagasse. The mRNA accumulation of several A. niger transporter-encoding...”
XP_002492232 Putative transporter, member of the sugar porter family from Komagataella phaffii GS115
30% identity, 94% coverage
Pc22g09740 uncharacterized protein from Penicillium rubens
30% identity, 83% coverage
SS1G_06402 hypothetical protein from Sclerotinia sclerotiorum 1980 UF-70
30% identity, 90% coverage
An11g05280 uncharacterized protein from Aspergillus niger
30% identity, 89% coverage
XP_001387242 Sugar transporter from Scheffersomyces stipitis CBS 6054
A3GIE8 Sugar transporter (Fragment) from Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)
33% identity, 85% coverage
- Genetic basis of the highly efficient yeast Kluyveromyces marxianus: complete genome sequence and transcriptome analyses
Lertwattanasakul, Biotechnology for biofuels 2015 - “...Ci_GXS1, GN107181; Ci_GXF1, GN107179; Ps_SUT1, XP_001387898; Ps_SUT2, XP_001384295; Ps_SUT3, XP_001386019; Ps_HXT2.4, XP_001387757; Ps_XUT1, XP_001385583; Ps_XUT2, XP_001387242; Ps_XUT3, XP_001387138; Ps_XUT4, XP_001386715; Ps_XUT5, XP_001385962; Ps_XUT6, XP_001386589; Ps_XUT7, XP_001387067; Ps_RGT2, XP_001386588; Ps_SLT1, XP_001383774; Kl_KHT1/RAG1, XP_453656; Kl_KHT2, GN107317; Kl_KHT3, XP_454897; Kl_FRT1, XP_454356; Kl_HGT1, XP_451484; Kl_HXT1, XP_455078; Kl_HXT14, XP_454897; Kl_HXT2, XP_453960;...”
- Functional survey for heterologous sugar transport proteins, using Saccharomyces cerevisiae as a host
Young, Applied and environmental microbiology 2011 - “...on February 10, 2017 by University of California, Berkeley YALI0B06391 A3GIE8 XUT2 NCBI 15 28 BLAST BLAST BLAST BLAST 29 29 16 16 24 24 Source or reference...”
VDAG_08381 galactose-proton symporter from Verticillium dahliae VdLs.17
30% identity, 92% coverage
CNAG_07641 monosaccharide transporter from Cryptococcus neoformans var. grubii H99
29% identity, 78% coverage
- Galectin-3 impacts Cryptococcus neoformans infection through direct antifungal effects
Almeida, Nature communications 2017 - “...partial XM_012192132.1 2.80 0.0000 8.7 61.1 CNAG_03876 Ras family protein XM_012194860.1 2.74 0.0000 1.3 9.1 CNAG_07641 Monosaccharide transporter XM_012194944.1 2.73 0.0000 106.2 709.0 CNAG_05685 Neutral amino acid transporter XM_012194030.1 2.72 0.0000 5.6 37.0 CNAG_01252 Thiosulfate/3-mercaptopyruvate sulfurtransferase XM_012191185.1 2.72 0.0000 1089.1 7234.7 CNAG_00162 Alternative oxidase, mitochondrial XM_012192590.1...”
KLMA_10546 high-affinity glucose transporter from Kluyveromyces marxianus DMKU3-1042
30% identity, 84% coverage
- Expansion and Diversification of MFS Transporters in Kluyveromyces marxianus
Varela, Frontiers in microbiology 2018 - “...Click here for additional data file. FIGURE S3 Recombination event leading to the formation of KLMA_10546. (A) A scheme depicting the recombination event between KMXK_A02950 and KMXK_A02930 is shown. The 5 end of KMXK_A02950 (gray) and the 3 end of KMXK_A02930 (purple) recombined to form KLMA_10546...”
- “...indicated with a red vertical line in position 230. Mismatches between the KMXK_A02950/KMXK_A02930 sequences and KLMA_10546 are shown in bold. Click here for additional data file. FIGURE S4 Construction of an HGT null mutant in K. marxianus NBRC1777. The CRISPR- Cas9 system was used to induce...”
SPSK_06192 sugar transporter from Sporothrix schenckii 1099-18
27% identity, 91% coverage
- Current Progress in Sporothrix brasiliensis Basic Aspects
Gómez-Gaviria, Journal of fungi (Basel, Switzerland) 2023 - “...SPBR_08225 0 99 C. neoformans Ccr4 SPSK_07136 SPBR_02436 0 96 Immune evasion C. albicans Hgt1 SPSK_06192 SPBR_04908 0 99 Msb2 SPSK_07127 SPBR_02423 0 97 Pra1 No found No found - - Rbt5 No found No found - - Sit1 SPSK_02970 SPBR_00416 0 98 A. fumigatus Hyp1/RodA...”
VDAG_02089 quinate permease from Verticillium dahliae VdLs.17
30% identity, 91% coverage
- Transcriptomic analysis of gene expression of Verticillium dahliae upon treatment of the cotton root exudates
Zhang, BMC genomics 2020 - “...VDAG_08086), 2 oligopeptide transporter (VDAG_06060, VDAG_05125), 1 MFS transporter gene (VDAG_09088), 1 quinate permease gene (VDAG_02089). Functional analysis for these candidate genes may be useful for the study of the pathogenicity molecular basis of V. dahliae . Fig. 9 Heatmap and GO analyses of up-regulated genes...”
- “...VDAG_01193 High-affinity nicotinic acid transporter 0.922962 4.474884 2.389495 1.367505 2.293024 1.158877 1.052356 1.003427 0.855293 11 VDAG_02089 Quinate permease 0.246652 1.239759 0.27095 0.039896 0.305545 0.133467 0.052949 0.090075 0 12 VDAG_02826 Voltage-gated potassium channel subunit beta-1 0.52636 1.770148 1.55752 0.539201 0.500666 0.471194 0.446343 0.28894 0.387249 13 VDAG_03714 Sugar...”
Afu3g00430 high-affinity glucose transporter, putative from Aspergillus fumigatus Af293
31% identity, 84% coverage
- Sub-telomere directed gene expression during initiation of invasive aspergillosis
McDonagh, PLoS pathogens 2008 - “...transporter 3.497276152 Afu2g09030 secreted dipeptidyl peptidase 2.4191786 Afu3g12010 high-affinity hexose transporter 3.821050502 Afu6g11500 dipeptidase 2.8865489 Afu3g00430 high-affinity glucose transporter Antigens 3.2509899 Afu8g04480 hexose transporter protein 5.642295426 Afu4g09320 antigenic dipeptidyl-peptidase Dpp4 3.6472387 Afu6g06730 l-fucose permease 4.316438927 Afu4g00870 antigenic cell wall galactomannoprotein Amino acid transport 7.128239041 Afu4g09580 major...”
BBA_03013 hexose transporter from Beauveria bassiana ARSEF 2860
30% identity, 84% coverage
- Nuclear Ssr4 Is Required for the In Vitro and In Vivo Asexual Cycles and Global Gene Activity of Beauveria bassiana
Shao, mSystems 2020 - “...the pentose phosphate pathway and the Calvin cycle ( 38 ), six hexose transporters (BBA_05766, BBA_03013, BBA_00397, BBA_09477, BBA8728, and BBA5674) critical for glucose uptake ( 39 ), and most of the glycosyl hydrolases (BBA_03946, BBA_05847, BBA_09379, and BBA_08796) involved in the hydrolysis of glycosidic bonds,...”
VDAG_07563 sugar transporter STL1 from Verticillium dahliae VdLs.17
28% identity, 94% coverage
- Identification of sugar transporter genes and their roles in the pathogenicity of Verticillium dahliae on cotton
Chen, Frontiers in plant science 2023 - “...2 (346bp), VdST12 -1 (346bp) and VdST12 -2 (367bp) designed to target VdST3 (Gene ID: VDAG_07563) or VdST12 (Gene ID: VDAG_04513) were amplified from Vd991 cDNA with VdST3 -F1/R1, VdST3 -F2/R2, VdST12 -F1/R1 and VdST12 -F2/R2 ( Table S2 ) and inserted into pTRV2 vector, respectively....”
- “...in the pathogenicity of V. dahliae . To verify this speculation, two VdST genes, VdST3 (VDAG_07563) and VdST12 (VDAG_04513), were selected for further characterization. Figure3 Expression profile analysis of the 65 VdST genes after sensing root exudates from different cotton varieties. VdX6, 12, 24, and 48...”
- Transcriptomic analysis of gene expression of Verticillium dahliae upon treatment of the cotton root exudates
Zhang, BMC genomics 2020 - “...GTGACGGCGGACAACTCTAC 3' 5' TGCACGCCCTTGAATGTAAT 3' VDAG_04513 hexose transporter protein 5' TCAACATTGCCATCCAGGTC 3' 5' CGAAGCACAGCTCGAAGAAG 3' VDAG_07563 sugar transporter STL1 5' AGTGCCCGTCGTCTACTTCTT 3' 5' GTTCTTGCCGTAACGCCTC 3' VDAG_08286 alpha-glucosides permease MPH2/3 5' GTATCGGCCAGACCAACCA 3' 5' CATCGCCACCATTTAACCC 3' VDAG_09088 MFS transporter 5' AGGAGAAGAAGGCCGTCGTG 3' 5' CCGTAAAGATTGCCGTGGTC 3' Results Identification...”
- “...VDAG_03038 encoding periplasmic trehalase, VDAG_03526 encoding Alpha-glucuronidase, VDAG_04513 encoding hexose transporter protein, VDAG_05015 encoding beta-galactosidase, VDAG_07563 encoding sugar transporter STL1, VDAG_08212 encoding lactose permease, VDAG_08286 encoding alpha-glucosides permease MPH2/3, VDAG_09088 encoding MFS transporter. The V. dahliae tubulin gene (VDAG_10074) was used an internal control. All reactions...”
ACA1_176180 transporter, major facilitator superfamily superfamily protein from Acanthamoeba castellanii str. Neff
31% identity, 85% coverage
- First Reports of Effects of Insulin, Human-like Insulin Receptors and Adapter Proteins in Acanthamoeba castellanii
Baig, Scientific reports 2020 - “...proteins as a match for human GLUTs (Fig. 10B ). The Acanthamoeba proteins ACA1_060920 and ACA1_176180, when aligned with human GLUT-4, exhibited the presence of identical amino acids within the ligand-binding active region in their sequence (Fig. 10C ). The complete amino acid sequence of protein...”
- “...and 404 amino acids) of the sequences compared (Fig. 10C ). Transcriptomics of ACA1_060920 and ACA1_176180 (Supplementary File- 1 A,B ) showed in fragments per kilobase of exon mode per million (FPKM) and percentages appeared to be around 22% and 30% respectively. Although the crystal structure...”
CNAG_06963 sugar transporter from Cryptococcus neoformans var. grubii H99
28% identity, 93% coverage
- Antifungal activity of eumelanin-inspired indoylenepheyleneethynylene against <i>Cryptococcus neoformans</i>
Conn, Frontiers in microbiology 2023 - “...Bax inhibitor 1 CNAG_06244 1.988950832 8.28E-292 Hypothetical protein CNAG_03385 PCL103 2.953559223 3.29E-287 G1/S-specific cyclin PCL1 CNAG_06963 3.077006018 7.14E-276 Hexose transporter HXT10 CNAG_06623 1.979003167 9.43E-274 Myo-insitol (putative) CNAG_05741 2.013204228 3.10E-264 Hypothetical protein (from the Thioesterase-like superfamily) CNAG_04183 2.558639688 5.75E-257 Hypothetical protein CNAG_03198 1.552579938 2.75E-254 40S ribosomal protein...”
- Transmembrane transporter expression regulated by the glucosylceramide pathway in Cryptococcus neoformans
Singh, BMC research notes 2015 - “...transporter (CNAG_05340), glucose transporter (CNAG_03772), membrane protein (CNAG_03912), membrane transport protein (CNAG_00539), and sugar transporter (CNAG_06963), are membrane-localized and have significantly altered gene expression levels. Therefore, we hypothesize that these genes function either independently or in tandem with a structurally modified cell wall/plasma membrane resulting from...”
- “...5-GCTTATCTTGCACTTACTGTCCTC-3, reverse: 5-TTTGGGAACAACGAGGTAGG-3; CNAG_03912 (Membrane-protein), forward: 5-GGTTTGCAAGGATTGATGCTTATC-3, reverse: 5-GTACGGTGGGTCAGAAAGGA-3; CNAG_00539 (Membrane-transport-protein), forward: 5-ACGCCGATGGATTATTACTAGC-3, reverse: 5-CGACCTAGCAGTTCCGAAAG-3; CNAG_06963 (Sugar-transporter), forward: 5-TGGTCCTATCGGTGACTACTCT-3, reverse: 5-GCCAACTTGAGACACAAGCA-3; CNAG_05340 (Monosaccharide-transporter), forward: 5-AGGGATCGTTAGCTTTTGGTATG-3, reverse: 5-GGAAAATTGTTCGAGGACGA-3; CNAG_03772 (Glucose-transporter), forward: 5-GGACTGGTGTCAACTTCATTTTC-3, reverse: 5-CGACACCAATGATACCGACA-3; CNAG_00334 (Heat-shock-protein), forward: 5-GAGTCGAGATCATCGCCAAC-3, reverse: 5-TTAACGTCAGCGTCGTCGTA-3; CNAG_03780 (Prcdna95), forward: 5-AAGGGTGTCGTTGCCTTCTAC-3, reverse: 5-ATAGCCAAAACCCTCCATCC-3; CNAG_00092...”
- The glucose sensor-like protein Hxs1 is a high-affinity glucose transporter and required for virulence in Cryptococcus neoformans
Liu, PloS one 2013 - “...3 ). The changes of transcription level of other tested HXT homologs, HXT4 (CNAG_06521), HXT6 (CNAG_06963) and HXT7 (CNAG_03432), were not significant (<2 fold). The transcription level of each HXT gene tested was not altered significantly by the lack of HXS1 (<2 fold) when compared to...”
Q64L87 Xylhp from Debaryomyces fabryi
29% identity, 95% coverage
- Advances in fungal sugar transporters: unlocking the potential of second-generation bioethanol production
Pereira, Applied microbiology and biotechnology 2025 - “...C. intermedia Leandro et al. ( 2006 ); Young et al. ( 2011 ) XylHP Q64L87 Glucose, xylose, galactose, fructose, and mannose D. hansenii Young et al. ( 2011 ) XUT1 A3LY10 Glucose, xylose, D-arabinose, L-arabinose, galactose, fructose, and mannose S. stipitis Young et al. (...”
- Machine learning and comparative genomics approaches for the discovery of xylose transporters in yeast
Fiamenghi, Biotechnology for biofuels and bioproducts 2022 - “...sequence alignment followed by comparison with the InterproScan results for Debaryomyces fabryi Xylhp (Uniprot accession Q64L87). Another interesting feature was GFV tripeptides, which are located on transmembrane portions of the transporters, but their direct relation to xylose transport is unclear. Nonetheless, all predicted transporters had this...”
- “...aligning the xylose transporters and using the sequence of Xylhp from Debaryomyces fabryi (Uniprot accession Q64L87) to predict domains and important sites through Interproscan; then, the non-cytoplasmic domains and probable sugar binding sites were isolated from the alignment and the HMM profile was created. We assumed...”
- Functional survey for heterologous sugar transport proteins, using Saccharomyces cerevisiae as a host
Young, Applied and environmental microbiology 2011 - “...or reference YOUNG ET AL. Y. lipolytica A3LY10 Q64L87 xylHP XUT1 B5RUJ3 DEHA2F19140 S. stipitis B5RSN0 DEHA2A14300 P0AGF4 Q6BW54 DEHA2B14278 xylE Q6BTD8 Q2MEV7...”
An04g10090 uncharacterized protein from Aspergillus niger
29% identity, 90% coverage
VDAG_02178 quinate permease from Verticillium dahliae VdLs.17
28% identity, 92% coverage
XP_042998602 uncharacterized protein from Ustilaginoidea virens
29% identity, 90% coverage
G0RRR0 Predicted protein from Hypocrea jecorina (strain QM6a)
28% identity, 85% coverage
- Advances in fungal sugar transporters: unlocking the potential of second-generation bioethanol production.
Pereira, Applied microbiology and biotechnology 2025 - “...A0A024SH75 Cellobiose, glucose, lactose, and sophorose T. reesei Havukainen et al. ( 2021b ) STR1 G0RRR0 Glucose, xylose, fructose, galactose, mannose, and L-arabinose T. reesei Sloothaak et al. ( 2016b ) STR3 G0RKF0 Glucose, xylose, fructose, galactose, and mannose T. reesei Sloothaak et al. ( 2016b...”
FVEG_10988 hypothetical protein from Fusarium verticillioides 7600
29% identity, 89% coverage
QUTD_EMENI / P15325 Quinate permease; Quinate transporter from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
qutD quinate permease (quinate transporter) from Emericella nidulans (see paper)
30% identity, 92% coverage
- function: Integral membrane transporter that imports quinic acid to be catabolized as a carbon source
subunit: Interacts with creB. - CharProtDB Description: Putative quinate permease with a predicted role in quinic acid utilization; mutants fail to grow on quinic acid as a sole carbon source at pH 6.5; Source:AspGD
- Major facilitator superfamily
Pao, Microbiology and molecular biology reviews : MMBR 1998 - “...Neurospora crassa Emericella nidulans 594 537 533 U54768 P11636 P15325 GB SP SP Glu2 Ssp Hex6 Rco Hup1 Cke Hup2 Cke Putative glucose transporter (fragment)...”
An11g01100 uncharacterized protein from Aspergillus niger
31% identity, 87% coverage
AO090001000069 No description from Aspergillus oryzae RIB40
30% identity, 83% coverage
CNC00060 sugar transporter from Cryptococcus neoformans var. neoformans JEC21
28% identity, 93% coverage
SS1G_10413 hypothetical protein from Sclerotinia sclerotiorum 1980 UF-70
30% identity, 86% coverage
NCU09358 hexose carrier protein from Neurospora crassa OR74A
29% identity, 86% coverage
CNH00490 sugar transporter from Cryptococcus neoformans var. neoformans JEC21
30% identity, 88% coverage
- Brain inositol is a novel stimulator for promoting Cryptococcus penetration of the blood-brain barrier
Liu, PLoS pathogens 2013 - “...CNB04770 CNAG_03991 GPCR 2.46 CNA00570 CNAG_00066 Membrane protein 2.39 CNL04850 CNAG_05137 Putative KDEL receptor 2.14 CNH00490 CNAG_07874 Sugar transporter 2.06 CNC00290 CNAG_03060 Multiple drug resistance protein 2.04 Cryptococcus can use inositol as a carbon source. Conversion of inositol to glucuronic acid by inositol oxygenases ( MIO...”
- Allergen1 regulates polysaccharide structure in Cryptococcus neoformans
Jain, Molecular microbiology 2013 - “...protein (CNE02910), and the carboxylic-acid transport protein (CNJ01360) were also up-regulated whereas the sugar transporter (CNH00490) was down-regulated. Genes classified under integral to membrane were also ranked in the analysis but did not reach significance ( Table S3 ). Differential expression of iron transporters and siderophores...”
- “...all1 was slow but comparable in low iron medium (data not shown). Additionally, sugar transporter (CNH00490) was down-regulated under all growth conditions. In summary, comparative transcriptional profiling supports a role of ALL1 in iron homeostasis under limited nutrition and iron conditions and a role in regulating...”
TC 2.A.1.1.39 / P49374 The high affinity glucose transporter, Hgt1 from Kluyveromyces lactis (Yeast) (Candida sphaerica) (see 2 papers)
XP_451484 hypothetical protein from Kluyveromyces lactis NRRL Y-1140
XP_451484 uncharacterized protein from Kluyveromyces lactis
29% identity, 87% coverage
- substrates: glucose
- Major facilitator superfamily
Pao, Microbiology and molecular biology reviews : MMBR 1998 - “...540 486 457 602 818 569 S59368 P13181 L21753 P49374 P32465 P23585 P32466 P32467 P38695 P39003 P39004 P40886 P43581 P40885 P39924 P42833 P47185 Z71687 P30605...”
- Genetic basis of the highly efficient yeast Kluyveromyces marxianus: complete genome sequence and transcriptome analyses
Lertwattanasakul, Biotechnology for biofuels 2015 - “...Ps_XUT7, XP_001387067; Ps_RGT2, XP_001386588; Ps_SLT1, XP_001383774; Kl_KHT1/RAG1, XP_453656; Kl_KHT2, GN107317; Kl_KHT3, XP_454897; Kl_FRT1, XP_454356; Kl_HGT1, XP_451484; Kl_HXT1, XP_455078; Kl_HXT14, XP_454897; Kl_HXT2, XP_453960; Kl_HXT3, XP_453088; Sc_HXT4/LGT1, NP_011960; Kl_STL1, XP_456249; Kl_RAG4, XP_455315; Kl_LAC12, XP_452193; Ca_HXT6, XP_719472. Genes for the initial catabolism of xylose, PPP, the conversion of PEP...”
- Comparative genomics of the white-rot fungi, Phanerochaete carnosa and P. chrysosporium, to elucidate the genetic basis of the distinct wood types they colonize
Suzuki, BMC genomics 2012 - “...CaHgt1 (CAA76406), CaHgt4 (XP_723173), CaHgt11 (XP_719597), CiGxf1 (AJ937350), CiGxs1 (AJ875406), GzHyp1 (EAA74528), HpGcr1 (AAR88143), KlHgt1 (XP_451484), KlRag1 (XP_453656), KlRag4 (CAA75114), Lb_EDR07962 (EDR07962), NcHyp1 (XP_328858), NcHxt3 (CAD21508), NcNCU00801(EAA34565.1), NcNCU08114 (XP_963873.1), NcRco3 (CAE76420), Pp_115604 (EED81359), Ps_ABN65648.2 (ABN65648.2), PsSut1 (AAD00266), ScHxt1 (M82963), ScHxt7 (NP_010629), ScSnf3 (P10870), SpGht1 (Q9P3U6), Tm-CAZ81962.1...”
- Galactose transport in Kluyveromyces lactis: major role of the glucose permease Hgt1.
Baruffini, FEMS yeast research 2006 (PubMed)- GeneRIF: Study confirmed the existence of a second galactose transporter which turned out to be HGT1, previously identified as encoding the high-affinity glucose carrier.
TC 2.A.1.1.40 / Q64L87 The xylose facilitator, Xylhp from Debaryomyces hansenii (Yeast) (Torulaspora hansenii)
30% identity, 91% coverage
CNAG_07874 sugar transporter from Cryptococcus neoformans var. grubii H99
30% identity, 88% coverage
- Galectin-3 impacts Cryptococcus neoformans infection through direct antifungal effects
Almeida, Nature communications 2017 - “...Glucose transporter XM_012191299.1 4.17 0.0000 6.9 126.2 CNAG_00393 1,4-alpha-glucan-branching enzyme XM_012198536.1 3.82 0.0000 1.2 16.8 CNAG_07874 Sugar transporter XM_012196714.1 3.81 0.0000 12.0 170.1 CNAG_04621 Glycogen(starch) synthase, variant XM_012192450.1 3.58 0.0000 31.8 384.2 CNAG_02943 Cytoplasmic protein XM_012194439.1 3.48 0.0000 12.4 140.0 CNAG_02165 Cytoplasmic protein XM_012193764.1 3.45 0.0000...”
- Brain inositol is a novel stimulator for promoting Cryptococcus penetration of the blood-brain barrier
Liu, PLoS pathogens 2013 - “...CNAG_03991 GPCR 2.46 CNA00570 CNAG_00066 Membrane protein 2.39 CNL04850 CNAG_05137 Putative KDEL receptor 2.14 CNH00490 CNAG_07874 Sugar transporter 2.06 CNC00290 CNAG_03060 Multiple drug resistance protein 2.04 Cryptococcus can use inositol as a carbon source. Conversion of inositol to glucuronic acid by inositol oxygenases ( MIO s)...”
SPBR_04908 sugar transporter from Sporothrix brasiliensis 5110
26% identity, 91% coverage
- Current Progress in Sporothrix brasiliensis Basic Aspects
Gómez-Gaviria, Journal of fungi (Basel, Switzerland) 2023 - “...0 99 C. neoformans Ccr4 SPSK_07136 SPBR_02436 0 96 Immune evasion C. albicans Hgt1 SPSK_06192 SPBR_04908 0 99 Msb2 SPSK_07127 SPBR_02423 0 97 Pra1 No found No found - - Rbt5 No found No found - - Sit1 SPSK_02970 SPBR_00416 0 98 A. fumigatus Hyp1/RodA No...”
FGSG_04700 hypothetical protein from Fusarium graminearum PH-1
29% identity, 89% coverage
Pc20g01790 uncharacterized protein from Penicillium rubens
28% identity, 93% coverage
- Functional characterization of a highly specific L-arabinose transporter from Trichoderma reesei
Havukainen, Microbial cell factories 2021 - “...B11697 Trire2_104072 deletion vector ( pyr4 ) This study Genes coding for P. chrysogenum AraT (Pc20g01790, GenBank CAP85508.1), P. guilliermondii Axt1 (GenBank GZ791040.1) and N. crassa LAT-1 (NCU02188, GenBank XP_959582.3) were ordered as synthetic genes with codon optimization for yeast expression (Twist Biosciences, San Francisco, CA,...”
- Engineering of Pentose Transport in Saccharomyces cerevisiae for Biotechnological Applications
Nijland, Frontiers in bioengineering and biotechnology 2019 - “...in more detail in the engineering section. Pc AraT The putative sugar transporter Pc AraT (Pc20g01790) of the filamentous fungus Penicillium chrysogenum , is upregulated in L-arabinose-limited cultures compared to D-glucose growth. When expressed in a L-arabinose-fermenting S. cerevisiae strain in which GAL2 was deleted, growth...”
- The Penicillium chrysogenum transporter PcAraT enables high-affinity, glucose-insensitive l-arabinose transport in Saccharomyces cerevisiae
Bracher, Biotechnology for biofuels 2018 - “...30-fold higher transcript level in l -arabinose-grown cultures compared to d -glucose-grown cultures, only one (Pc20g01790) restored growth on l -arabinose upon expression in an engineered l -arabinose-fermenting S. cerevisiae strain in which the endogenous l -arabinose transporter, GAL2 , had been deleted. Sugar transport assays...”
- “...Genes encoding the five putative transporters Pc13g04640 [Genbank: CAP91533.1], Pc13g08230 [Genbank: CAP91892.1], Pc16g05670 [Genbank: CAP93237.1], Pc20g01790 ( PcaraT ) [Genbank: CAP85508.1] and Pc22g14520 [Genbank: CAP98740.1] were codon-pair optimized [ 42 ] for expression in S. cerevisiae and cloned into the plasmid pPWT007 [ 43 ] resulting...”
An02g08230 uncharacterized protein from Aspergillus niger
30% identity, 88% coverage
XP_002489348 Putative transporter, member of the sugar porter family from Komagataella phaffii GS115
29% identity, 92% coverage
Pc21g12210 uncharacterized protein from Penicillium rubens
30% identity, 86% coverage
ATEG_02489 uncharacterized protein from Aspergillus terreus NIH2624
29% identity, 93% coverage
- Transcriptome Profiling-Based Analysis of Carbohydrate-Active Enzymes in Aspergillus terreus Involved in Plant Biomass Degradation
Corrêa, Frontiers in bioengineering and biotechnology 2020 - “...the 48 h incubation period, namely ATEG_07791, ATEG_03475, ATEG_07105, ATEG_04988, ATEG_01556, ATEG_07124, ATEG_08653, ATEG_07144, ATEG_03527, ATEG_02489, ATEG_07114, ATEG_04070, ATEG_07053, ATEG_04137, ATEG_03190, and ATEG_05008. RT-qPCR Validation of in silico RNA-Seq Transcriptome Data Expression profiles for selected A. terreus CAZyme-encoding and other genes significantly up-regulated on SB and...”
AO090010000063 No description from Aspergillus oryzae RIB40
28% identity, 94% coverage
CTRG_00558 conserved hypothetical protein from Candida tropicalis MYA-3404
29% identity, 88% coverage
CNBG_4491 uncharacterized protein from Cryptococcus deuterogattii R265
29% identity, 94% coverage
- Copy number variation contributes to cryptic genetic variation in outbreak lineages of Cryptococcus gattii from the North American Pacific Northwest
Steenwyk, BMC genomics 2016 - “...single copy, while VGIIb and VGIIc isolates have experienced deletions ( CNBG_9639 , CNBG_2482 , CNBG_4491 , CNBG_2944 ) (Additional file 3 ). Functional analysis of CNV genes We performed enrichment analysis of genes overlapping CNVs to broadly characterize their functional associations. First, we identified orthologs...”
- “...Several Major Facilitator Superfamily (MFS) domains were predicted in the high V ST genes including CNBG_4491 (VGIIa: one copy, and VGIIb and VGIIc: zero copies), CNBG_9477 (VGIIa: one copy, and VGIIb and VGIIc: zero copies), and CNBG_9094 (VGIIa and VGIIb: two copies, and VGIIc: one copy)....”
FVEG_03992 hypothetical protein from Fusarium verticillioides 7600
28% identity, 90% coverage
XP_001387138 sugar transporter, putative from Scheffersomyces stipitis CBS 6054
A3GHU5 Sugar transporter, putative from Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)
28% identity, 85% coverage
- Genetic basis of the highly efficient yeast Kluyveromyces marxianus: complete genome sequence and transcriptome analyses
Lertwattanasakul, Biotechnology for biofuels 2015 - “...Ci_GXF1, GN107179; Ps_SUT1, XP_001387898; Ps_SUT2, XP_001384295; Ps_SUT3, XP_001386019; Ps_HXT2.4, XP_001387757; Ps_XUT1, XP_001385583; Ps_XUT2, XP_001387242; Ps_XUT3, XP_001387138; Ps_XUT4, XP_001386715; Ps_XUT5, XP_001385962; Ps_XUT6, XP_001386589; Ps_XUT7, XP_001387067; Ps_RGT2, XP_001386588; Ps_SLT1, XP_001383774; Kl_KHT1/RAG1, XP_453656; Kl_KHT2, GN107317; Kl_KHT3, XP_454897; Kl_FRT1, XP_454356; Kl_HGT1, XP_451484; Kl_HXT1, XP_455078; Kl_HXT14, XP_454897; Kl_HXT2, XP_453960; Kl_HXT3, XP_453088;...”
- Advances in fungal sugar transporters: unlocking the potential of second-generation bioethanol production
Pereira, Applied microbiology and biotechnology 2025 - “...S. stipitis Young et al. ( 2011 ); Watanabe et al. ( 2016 ) XUT3 A3GHU5 Glucose, xylose, D-arabinose, L-arabinose, galactose, fructose, and mannose S. stipitis Young et al. ( 2011 ); Watanabe et al. ( 2016 ) The specificity of fungal STs is closely related...”
- Functional survey for heterologous sugar transport proteins, using Saccharomyces cerevisiae as a host
Young, Applied and environmental microbiology 2011 - “...XUT6 Q6CFJ6 A3LY79 XUT5 Q6CG30 A3M0B9 XUT4 YALI0B01342 A3GHU5 XUT3 BLAST BLAST BLAST BLAST BLAST NCBI NCBI NCBI; intron-free version synthesized by Blue Heron...”
XP_042999770 uncharacterized protein from Ustilaginoidea virens
29% identity, 90% coverage
BC1G_11623 hypothetical protein from Botrytis cinerea B05.10
30% identity, 88% coverage
- The BcLAE1 is involved in the regulation of ABA biosynthesis in Botrytis cinerea TB-31
Wei, Frontiers in microbiology 2022 - “...levels of five putative sugar transporters and permeases increased significantly, namely BC1G_08389 (FC of 1.42), BC1G_11623 (FC of 3.55), BC1G_05673 (FC of 3.12), BC1G_12189 (FC of 3.01), and BC1G_05489 (FC of 1.79; Baruffini et al., 2006 ). Moreover, the transcriptional level of some -glucosidases was also...”
- “..., BcFBA , BcICL , BcMLS , BcNRPS5 , BcPKS19 , BcPYC , BC1G_05489, and BC1G_11623 genes to design primers, and used the isolated RNA for RT-qPCR verification ( Supplementary Figure 3 ). The results indicated that the selected genes basically conformed to the expression pattern...”
- IQD1 Involvement in Hormonal Signaling and General Defense Responses Against Botrytis cinerea
Barda, Frontiers in plant science 2022 - “...than tenfold. To validate the RNA-Seq data, six genes were selected for qRT-PCR analysis, namely, Bc1G_11623 (encoding a MFS sugar transporter), Bc1G_10358 (encoding a hypothetical protein), Bc1G_04691 (encoding a cellulase), Bc1G_02144 (encoding a choline dehydrogenase), Bc1G_12885 (encoding a MFS transporter) and Bc1G_13938 (encoding a sialidase). The...”
XP_001382755 High-affinity Glucose Transporter (putative) from Scheffersomyces stipitis CBS 6054
XP_001382755 High-affinity Glucose Transporter (putative) from Pichia stipitis CBS 6054
28% identity, 93% coverage
- The Penicillium chrysogenum transporter PcAraT enables high-affinity, glucose-insensitive l-arabinose transport in Saccharomyces cerevisiae
Bracher, Biotechnology for biofuels 2018 - “...[ 54 ]. Gene accession numbers were ScGAL2 : P13181, PcaraT : CAP85508, SsaraT : XP_001382755, Atstp2 : OAP13698, Kmaxt1 : GZ791039, Pgaxt1 : GZ791040, Amlat1 : AY923868, Amlat2 : AY923869, Nclat - 1 : EAA30346, Mtlat - 1 : XP_003663698. Results Chemostat-based transcriptome analysis of...”
- Genetic basis of the highly efficient yeast Kluyveromyces marxianus: complete genome sequence and transcriptome analyses
Lertwattanasakul, Biotechnology for biofuels 2015 - “.... The accession numbers of amino acid sequences of sugar transporters are as follows: Ps_HGT2, XP_001382755; Sc_HXT7, NP_010629; Sc_GAL2, NP_013182; Dh_xylhp, AY347871; Ci_GXS1, GN107181; Ci_GXF1, GN107179; Ps_SUT1, XP_001387898; Ps_SUT2, XP_001384295; Ps_SUT3, XP_001386019; Ps_HXT2.4, XP_001387757; Ps_XUT1, XP_001385583; Ps_XUT2, XP_001387242; Ps_XUT3, XP_001387138; Ps_XUT4, XP_001386715; Ps_XUT5, XP_001385962; Ps_XUT6, XP_001386589;...”
NCU00988 MFS quinate transporter from Neurospora crassa OR74A
29% identity, 91% coverage
- The regulatory and transcriptional landscape associated with carbon utilization in a filamentous fungus
Wu, Proceedings of the National Academy of Sciences of the United States of America 2020 - “...pectate lyases genes ply-1 and ply-2 (NCU06326 and NCU08176), the galacturonic acid transporter gene gat-1 (NCU00988), the exo-polygalacturonase gene gh28-2 (NCU06961), and orthologs of gaaA , gaaB , and gaaC (NCU09533, NCU07064, and NCU09532, respectively), encoding enzymes for galacturonic acid catabolism ( Fig. 2 B and...”
- “...and NCU02344), a starch active polysaccharide monooxygenase (NCU08746), a galacturonic acid transporter ( gat-1 ; NCU00988), an exogalacturonase (NCU06961), rhamnogalacturonan acetylesterase (NCU09976), a secreted phospholipase (NCU06650), and acid phosphatase ( pho-3 ; NCU08643) ( Dataset S7 ) ( Fig. 6 C ). Three genes encoding LaeA-like...”
- Identification and characterization of a galacturonic acid transporter from Neurospora crassa and its application for Saccharomyces cerevisiae fermentation processes
Benz, Biotechnology for biofuels 2014 - “...utilization of pectin-rich feedstocks for the production of platform chemicals or biofuels. Results Identification of NCU00988 from N. crassa as a candidate D-galacturonic acid transporter To identify candidate D-GalA transporters, we took advantage of a recently generated polysaccharide-biased co-expression matrix [ 37 ]. In that study,...”
- “...three transporter genes with the strongest induction by pectin (>1,000-fold; log 2 >10) were NCU01132, NCU00988, and NCU01231. For these we tested whether they are specifically induced by D-GalA alone. To this end, cultures of N. crassa wild-type (WT) pre-grown in sucrose for 16h were transferred...”
- Transcriptional comparison of the filamentous fungus Neurospora crassa growing on three major monosaccharides D-glucose, D-xylose and L-arabinose
Li, Biotechnology for biofuels 2014 - “...48.96 244.36 NCU00450 Sucrose transporter 28.78 52.91 23.15 NCU00801 MFS lactose permease 6.10 25.15 24.96 NCU00988 MFS quinate transporter 0.18 47.98 0.86 NCU01494 MFS sugar transporter 1.34 6.47 2.07 NCU01813 High affinity glucose transporter 23.68 38.96 16.02 NCU01868 MFS maltose permease malp 0.41 2.42 0.54 NCU02582...”
- Deciphering transcriptional regulatory mechanisms associated with hemicellulose degradation in Neurospora crassa
Sun, Eukaryotic cell 2012 - “...7.19e19), including 11 carbohydrate transporter genes (NCU00988, NCU01132, NCU02188, NCU02238, NCU02582, NCU05853, NCU06138, NCU06305, NCU06358, NCU08114, and...”
- Systems analysis of plant cell wall degradation by the model filamentous fungus Neurospora crassa
Tian, Proceedings of the National Academy of Sciences of the United States of America 2009 - “...major facilitator super family transporters (NCU00801, NCU00988, NCU01231, NCU04963, NCU05519, NCU05853, NCU05897, NCU06138, NCU08114, and NCU10021) and 23...”
Pc16g05670 uncharacterized protein from Penicillium rubens
28% identity, 91% coverage
- The Penicillium chrysogenum transporter PcAraT enables high-affinity, glucose-insensitive l-arabinose transport in Saccharomyces cerevisiae
Bracher, Biotechnology for biofuels 2018 - “...GeneArt (Regensburg, Germany). Genes encoding the five putative transporters Pc13g04640 [Genbank: CAP91533.1], Pc13g08230 [Genbank: CAP91892.1], Pc16g05670 [Genbank: CAP93237.1], Pc20g01790 ( PcaraT ) [Genbank: CAP85508.1] and Pc22g14520 [Genbank: CAP98740.1] were codon-pair optimized [ 42 ] for expression in S. cerevisiae and cloned into the plasmid pPWT007 [...”
- “..., amdSYM , pADH1 -Pc13g08230- tPMA1 This study pPWT116 ampR KanMX , amdSYM , pADH1 -Pc16g05670- tPMA1 This study pPWT118 ampR KanMX , amdSYM , pADH1 -Pc20g01790 (PcaraT) - tPMA1 This study pPWT123 ampR KanMX , amdSYM , pADH1 -Pc22g14520- tPMA1 This study pUD354 pMK -...”
XP_001386589 Sugar transporter, putative (STL12) from Scheffersomyces stipitis CBS 6054
A3M0N4 Sugar transporter, putative (STL12) from Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)
29% identity, 90% coverage
- Genetic basis of the highly efficient yeast Kluyveromyces marxianus: complete genome sequence and transcriptome analyses
Lertwattanasakul, Biotechnology for biofuels 2015 - “...Ps_SUT3, XP_001386019; Ps_HXT2.4, XP_001387757; Ps_XUT1, XP_001385583; Ps_XUT2, XP_001387242; Ps_XUT3, XP_001387138; Ps_XUT4, XP_001386715; Ps_XUT5, XP_001385962; Ps_XUT6, XP_001386589; Ps_XUT7, XP_001387067; Ps_RGT2, XP_001386588; Ps_SLT1, XP_001383774; Kl_KHT1/RAG1, XP_453656; Kl_KHT2, GN107317; Kl_KHT3, XP_454897; Kl_FRT1, XP_454356; Kl_HGT1, XP_451484; Kl_HXT1, XP_455078; Kl_HXT14, XP_454897; Kl_HXT2, XP_453960; Kl_HXT3, XP_453088; Sc_HXT4/LGT1, NP_011960; Kl_STL1, XP_456249; Kl_RAG4, XP_455315;...”
- Functional survey for heterologous sugar transport proteins, using Saccharomyces cerevisiae as a host
Young, Applied and environmental microbiology 2011 - “...Q6C2L7 Q6CCU6 Q6CCJ1 YALI0C06424 YALI0C08943 A3GHF2 XUT7 YALI0F06776 A3M0N4 XUT6 Q6CFJ6 A3LY79 XUT5 Q6CG30 A3M0B9 XUT4 YALI0B01342 A3GHU5 XUT3 BLAST BLAST BLAST...”
SS1G_09710 hypothetical protein from Sclerotinia sclerotiorum 1980 UF-70
29% identity, 88% coverage
AO090003000782 No description from Aspergillus oryzae RIB40
29% identity, 88% coverage
VDAG_07259 quinate permease from Verticillium dahliae VdLs.17
27% identity, 90% coverage
CTRG_04615 high-affinity glucose transporter from Candida tropicalis MYA-3404
28% identity, 91% coverage
TC 2.A.1.1.131 / AIU34725.1 Myo-inositol-specific uptake transporter, ITR1 of 509 aas and 12 TMSs from Pneumocystis carinii
30% identity, 82% coverage
- substrates: myo-inositol
tcdb comment: The Km for myo-inositol is about 1 mM; glucose and other inositols are apparently not transported (Cushion et al. 2016)
Pc21g19770 uncharacterized protein from Penicillium rubens
28% identity, 91% coverage
Pc06g01340 uncharacterized protein from Penicillium rubens
30% identity, 69% coverage
Afu8g01180 MFS sugar transporter, putative from Aspergillus fumigatus Af293
26% identity, 91% coverage
- Evolutionary Analysis of Sequence Divergence and Diversity of Duplicate Genes in Aspergillus fumigatus
Yang, Evolutionary bioinformatics online 2012 - “...1.79 [1.81, 0.81] Afu5g01040 1.18 [1.12, 2.70] Afu6g09970 0.61 [1.25, 2.20] Afu5g01160 1.17 [0.65, 2.17] Afu8g01180 0.57 [1.44, 1.32] Afu8g04470 1.16 [0.66, 2.13] Afu6g11320 1.79 [2.31, 1.80] Afu7g00390 1.13 [0.49, 1.91] Afu3g01120 0.66 [0.98, 1.94] Afu5g00980 1.13 [0.82, 2.31] Afu1g10370 0.97 [1.82, 1.53] Afu7g06660 1.11 [0.56,...”
Q6CG30 YALI0B01342p from Yarrowia lipolytica (strain CLIB 122 / E 150)
26% identity, 93% coverage
Q6CFJ6 YALI0B06391p from Yarrowia lipolytica (strain CLIB 122 / E 150)
28% identity, 92% coverage
Q1EG32 Putative xylose permease from Hypocrea jecorina
29% identity, 80% coverage
HPODL_02401 myo-inositol transporter 1 from Ogataea parapolymorpha DL-1
30% identity, 91% coverage
ATEG_03190 uncharacterized protein from Aspergillus terreus NIH2624
28% identity, 97% coverage
- Transcriptome Profiling-Based Analysis of Carbohydrate-Active Enzymes in Aspergillus terreus Involved in Plant Biomass Degradation
Corrêa, Frontiers in bioengineering and biotechnology 2020 - “...namely ATEG_07791, ATEG_03475, ATEG_07105, ATEG_04988, ATEG_01556, ATEG_07124, ATEG_08653, ATEG_07144, ATEG_03527, ATEG_02489, ATEG_07114, ATEG_04070, ATEG_07053, ATEG_04137, ATEG_03190, and ATEG_05008. RT-qPCR Validation of in silico RNA-Seq Transcriptome Data Expression profiles for selected A. terreus CAZyme-encoding and other genes significantly up-regulated on SB and SH in comparison to growth...”
TRIREDRAFT_104072 hexose transporter from Trichoderma reesei QM6a
29% identity, 78% coverage
BC1G_08389 hypothetical protein from Botrytis cinerea B05.10
30% identity, 92% coverage
- The BcLAE1 is involved in the regulation of ABA biosynthesis in Botrytis cinerea TB-31
Wei, Frontiers in microbiology 2022 - “...showed that the transcriptional levels of five putative sugar transporters and permeases increased significantly, namely BC1G_08389 (FC of 1.42), BC1G_11623 (FC of 3.55), BC1G_05673 (FC of 3.12), BC1G_12189 (FC of 3.01), and BC1G_05489 (FC of 1.79; Baruffini et al., 2006 ). Moreover, the transcriptional level of...”
- Comparative transcriptome analysis between an evolved abscisic acid-overproducing mutant Botrytis cinerea TBC-A and its ancestral strain Botrytis cinerea TBC-6
Ding, Scientific reports 2016 - “...especially during the stationary phase of the fermentation process. For example, the transcript abundance of Bc1G_08389, which encodes a HGT1, was more than 236.68-fold higher in the TBC-A-120h sample than that of the TBC-6-120h sample (RPKM values 357.38 vs. 1.51). Expression levels of genes encoding plant...”
CD36_01840 high-affinity glucose transporter, putative from Candida dubliniensis CD36
28% identity, 91% coverage
QAY_NEUCR / P11636 MFS-type transporter qa-x; Quinate permease; Quinate transporter; Quinic acid degradation cluster protein y from Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) (see 6 papers)
TC 2.A.1.1.7 / P11636 Quinate:H+ symporter from Neurospora crassa (see 2 papers)
NCU06026 quinate permease from Neurospora crassa OR74A
28% identity, 93% coverage
- function: MFS-type transporter; part of the qa gene cluster that mediates the catabolism of quinic acid (QA) and as such, allows the use of QA as a sole carbon source (PubMed:2525625, PubMed:6458044). Involved in the upatke of QA (PubMed:1533844). The qa cluster encodes 3 inducible enymes (qa-2, qa-3 and qa-4) catalyzing the first three reactions in the catabolism of quinic acid to protocatechuic acid (also known as 3,4-Dihydroxybenzoic acid) (Probable).
disruption phenotype: Impairs growth on quinic acid as a sole carbon source and leads to very low inducible levels of qa-2 and qa-3 enzyme activities. - substrates: H+, Quinate
- The regulatory and transcriptional landscape associated with carbon utilization in a filamentous fungus
Wu, Proceedings of the National Academy of Sciences of the United States of America 2020 - “...bound by CRE-1. These MFS sugar transporters included NCU04537 (monosaccharide transporter), NCU04963 (high-affinity glucose transporter), NCU06026 (quinate permease), NCU05897 ( sut-28 ), NCU10021 ( hgt-1 ), NCU00821 (sugar transporter), and NCU05627 (high-affinity glucose transporter ght-1 ). The remaining set of 21 genes included a number of...”
- Engineering Saccharomyces cerevisiae for co-utilization of D-galacturonic acid and D-glucose from citrus peel waste
Protzko, Nature communications 2018 - “...strains cloning were list in Supplementary Data 3 . Phylogenetic analysis Fungal homologues of GAT-1, (NCU06026, quinate permease), from representative ascomycete and basidiomycete species were identified by BLAST and retrieved from the NCBI database. Protein sequences were aligned by Phylogeny.fr 71 and a phylogenetic tree constructed...”
- Identification and characterization of a galacturonic acid transporter from Neurospora crassa and its application for Saccharomyces cerevisiae fermentation processes
Benz, Biotechnology for biofuels 2014 - “...transporter, which presumably can be attributed to the fact that GAT-1 and the quinate permease (NCU06026; quinate-Y [ 39 - 41 ]; Broad Institute of Harvard and MIT [ http://www.broadinstitute.org/ ]) indeed share considerable homology (39% identity, 54% similarity [ 42 ]; Additional file 2 :...”
- “...plate-reader spectrophotometer (Paradigm; Beckman-Coulter, Brea, CA, USA) at 487nm. Phylogenetic analysis Protein sequences of GAT-1, NCU06026 (quinate permease), and fungal homologs from representative ascomycete and basidiomycete species were retrieved from the NCBI database. Sequences were aligned and a phylogenetic tree constructed using the program Phylogeny.fr [...”
- Transcriptional comparison of the filamentous fungus Neurospora crassa growing on three major monosaccharides D-glucose, D-xylose and L-arabinose
Li, Biotechnology for biofuels 2014 - “...26.59 12.88 NCU05350 Sugar transporter 0.37 10.25 0.55 NCU05585 MFS quinate transporter 1.01 47.89 1.52 NCU06026 Quinate permease 5.99 37.83 13.25 NCU06358 High affinity glucose transporter RGT2 1.71 51.82 18.50 NCU06384 MFS sugar transporter 0.08 2.88 1.11 NCU06522 MFS maltose permease 1.35 3.39 1.98 NCU07054 Sugar...”
- Transcriptome and Secretome Analyses of the Wood Decay Fungus Wolfiporia cocos Support Alternative Mechanisms of Lignocellulose Conversion
Gaskell, Applied and environmental microbiology 2016 - “...crassa quinate transporter (UniProt accession number P11636). The abovementioned putative siderophore iron transporter (Table 2) Wolco_166774 showed only...”
- Major facilitator superfamily
Pao, Microbiology and molecular biology reviews : MMBR 1998 - “...crassa Neurospora crassa Emericella nidulans 594 537 533 U54768 P11636 P15325 GB SP SP Glu2 Ssp Hex6 Rco Hup1 Cke Hup2 Cke Putative glucose transporter...”
- “...of Trypanosoma brucei P37021 P09830 P09098 P21906 P43581 P13181 P11636 P30605 P07921 P15685 S59368 Q07647 U11843 P15686 Q02563 X78855 Q06222 SP SP SP SP SP SP...”
B5RSN0 DEHA2A14300p from Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)
28% identity, 91% coverage
PGTG_21065 uncharacterized protein from Puccinia graminis f. sp. tritici CRL 75-36-700-3
30% identity, 79% coverage
COCC4DRAFT_80536 general substrate transporter from Bipolaris maydis
31% identity, 73% coverage
- The Effects of Mycovirus BmPV36 on the Cell Structure and Transcription of Bipolaris maydis
Wang, Journal of fungi (Basel, Switzerland) 2024 - “...by 71.23%, 56.89%, 67.36, and 65%. Genes of BM2 encoding MFS domain-containing protein (COCC4DRAFT_82543 and COCC4DRAFT_80536) were down-regulated by 76.6% and 52.2%, while those of BM5 down-regulated by 79.73% and 81.82%. Genes of BM2 encoding toxin synthesis-related genes (COCC4DRAFT_123791 and COCC4DRAFT_50090) were down-regulated by 75% and...”
An14g03990 uncharacterized protein from Aspergillus niger
30% identity, 98% coverage
Q6CAP1 YALI0D01111p from Yarrowia lipolytica (strain CLIB 122 / E 150)
26% identity, 86% coverage
An01g08780 uncharacterized protein from Aspergillus niger
29% identity, 98% coverage
- Genome-wide transcription landscape of citric acid producing Aspergillus niger in response to glucose gradient
Zheng, Frontiers in bioengineering and biotechnology 2023 - “...corresponding clusters. In consideration of gene expression FPKM value, mstA , mstH , mstF, mstG, An01g08780, An06g00620, and An18g01700 showed high expression when glucose was depleted ( Figure 4 ), indicating these genes played curial roles for sugar uptake under the condition of no-carbon availability. In...”
- In Silico Analysis of Putative Sugar Transporter Genes in Aspergillus niger Using Phylogeny and Comparative Transcriptomics
Peng, Frontiers in microbiology 2018 - “...from Clade A (An06g02270), Clade D (An12g07450/ mstA and An15g03940/ mstH ), and Clade I (An01g08780) were well-expressed in almost all the tested carbon sources (Cluster C8 in the heatmap of Figure 3 ), which supports their broad sugar specificity and essential role for fungal physiology....”
CPAR2_108370 uncharacterized protein from Candida parapsilosis
28% identity, 97% coverage
STP10_ARATH / Q9LT15 Sugar transport protein 10; AtSTP10; D-glucose-H(+) symport protein STP10; D-glucose-proton symporter STP10; Hexose transporter 10 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
TC 2.A.1.1.124 / Q9LT15 The high affinity sugar:H+ symporter (sugar uptake) porter of 514 aas and 12 TMSs, STP10. It transports glucose, galactose and mannose, and is therefore a hexose transporter (Rottmann et al. 2016). The 2.4 from Arabidopsis thaliana
NP_188628 Major facilitator superfamily protein from Arabidopsis thaliana
AT3G19940 sugar transporter, putative from Arabidopsis thaliana
26% identity, 87% coverage
- function: Hexose-H(+) symporter that catalyzes the high-affinity uptake of glucose, galactose and mannose (PubMed:26893494). Proton-coupled symporter responsible for the uptake of glucose from the apoplast into the cells (Probable).
catalytic activity: D-glucose(out) + H(+)(out) = D-glucose(in) + H(+)(in) (RHEA:69556)
catalytic activity: D-mannose(out) + H(+)(out) = D-mannose(in) + H(+)(in) (RHEA:69560)
catalytic activity: D-galactose(in) + H(+)(in) = D-galactose(out) + H(+)(out) (RHEA:29019)
disruption phenotype: No visible phenotype under normal growth conditions. - substrates: Galactose, Hexoses, Mannose, glucose
tcdb comment: Å structure with glucose bound has been solved, explaining high affinity sugar recognition (Paulsen et al. 2019). The results suggest a proton donor/acceptor pair that links sugar transport to proton translocation. It contains a Lid domain, conserved in all sugar transport proteins, that locks the mobile transmembrane domains through a disulfide bridge, and creates a protected environment which allows efficient coupling of the proton gradient to drive sugar uptake (Paulsen et al. 2019) - Evolutionary balance between foldability and functionality of a glucose transporter
Choi, Nature chemical biology 2022 - “...transporter 1 (O97467), Staphylococcus epidermidis Glucose transporter (A0A0H2VG78) and Arabidopsis thaliana Sugar transport protein 10 (Q9LT15). The PDB accession number for structures for these reference proteins are 4ZWC (P11169), 4GBZ (P0AGF4), 6RW3 (O97467), 4LDS (A0A0H2VG78) and 6H7D (Q9LT15). Since the sequences are divergent and therefore difficult...”
- “...4LDS and 6H7D). Also, The following UniProt IDs were used (P11169, P0AGF4, O97467, A0A0H2VG78 and Q9LT15). Code availability A program, written in LabView, to control the magnetic tweezers apparatus has been deposited in Github ( https://github.com/tyyoonlab/Science_aaw8208 ) and is available at Zenodo (doi:10.5281/zenodo.3528913). Codes for analyzing...”
- Utilization of AlphaFold2 to Predict MFS Protein Conformations after Selective Mutation.
Xiao, International journal of molecular sciences 2022 - “...To date, several structures of MFS proteins (UniProt ID: P0AA76, P0AEY8, P0AGF4, P02920, Q6MLJ0, and Q9LT15) have been found in both the outward- and inward-opening conformations [ 9 , 10 , 11 , 12 , 30 , 31 , 32 , 33 , 34 , 35...”
- “...5AYM) for Q6MLJ0, 0.88 (inward, PDB ID: 7AAR) and 0.75 (outward, PDB ID: 7AAQ) for Q9LT15, and 0.39 (inward, PDB ID: 4ZP0) and 1.95 (outward, PDB ID: 6GV1) for P0AEY8. Most of these predicted structures, including mutants, have approximately 1 or less deviation from the experimentally...”
- Structural comparison of GLUT1 to GLUT3 reveal transport regulation mechanism in sugar porter family
Custódio, Life science alliance 2021 - “...), GLUT4 (UniProt P14672 ), rGLUT5 (UniProt P43427 ), bGLUT5 (UniProt P58353 ), atSTP10 (UniProt Q9LT15 ), XylE (UniProt P0AGF4 ), and GlcPse (UniProt A0A0H2VG78 ). Conserved residues are highlighted with gray-scale. Alpha helices as found in GLUT1 are represented above the sequence as colored tubes....”
- SLC22A14 is a mitochondrial riboflavin transporter required for sperm oxidative phosphorylation and male fertility.
Kuang, Cell reports 2021 - “...etal., 2019 ) revealed that both the human SLC22A14 and the A.thaliana STP10 (UniProt entry Q9LT15) belonged to the Major facilitator, sugar transporter-like protein family (IPR005828), strengthening our confidence that the correct template had been chosen. Finally, quality of the models was assessed using MolProbity (...”
- Crystal structure of the plant symporter STP10 illuminates sugar uptake mechanism in monosaccharide transporter superfamily
Paulsen, Nature communications 2019 - “...plant life. Methods Protein purification The gene encoding the Arabidopsis thaliana protein STP10 (Accession number Q9LT15 [ https://www.uniprot.org/uniprot/Q9LT15 ]) was introduced into an expression construct based on p423_GAL1 40 with a C-terminal purification tag containing a thrombin cleavage site and a deca-histidine tag. The primers used...”
- Molecular mechanism of sugar transport in plants unveiled by structures of glucose/H+ symporter STP10.
Bavnhøj, Nature plants 2021 (PubMed)- GeneRIF: Molecular mechanism of sugar transport in plants unveiled by structures of glucose/H(+) symporter STP10.
- STP10 encodes a high-affinity monosaccharide transporter and is induced under low-glucose conditions in pollen tubes of Arabidopsis.
Rottmann, Journal of experimental botany 2016 - GeneRIF: A high-affinity glucose uptake system is induced in growing pollen tubes under low glucose conditions and that this regulation may occur through the hexokinase pathway. [AtSTP10]
- Phaseolus vulgaris STP13.1 is an H+-coupled monosaccharide transporter, present in source leaves and seed coats, with higher substrate affinity at depolarized potentials
Pegler, Plant direct 2024 - “...is presented as the mean standard error. Figure S1: Amino acid sequence alignment of AtSTP10 (At3g19940), AtSTP13 (At5G26340) BvSTP13 (Bevul.3G139500), MdSTP13a (MD13G1189100), MtSTP13.1 (Medtr5g006070), MtSTP13.2 (Medtr1g104780), PvSTP13.1 (Phvul.002G046800), PvSTP13.2 (Phvul.007G055100) and TaSTP13 (Traes_4DL_CFC191A06). Amino acid residues encased in a red box indicate residues participating in AtSTP10...”
- Calmodulin-Domain Protein Kinase PiCDPK1 Interacts with the 14-3-3-like Protein NtGF14 to Modulate Pollen Tube Growth
Scheible, Plants (Basel, Switzerland) 2024 - “...Epsin family of endocytic proteins Accessory proteins that facilitate vesicle biogenesis [ 41 ] A0A1S4AFS9 AT3G19940 Sugar Transport Protein 10 Sugar Transport Protein Glucose uptake in growing pollen tubes [ 42 ] A0A1S4AKF1 AT1G16010 Magnesium Transporter 2 Transmembrane magnesium transporter Tonoplast-targeted transporter for vacuolar accumulation of...”
- Exploring the genic resources underlying metabolites through mGWAS and mQTL in wheat: From large-scale gene identification and pathway elucidation to crop improvement
Chen, Plant communications 2021 - “...behind the accumulation of the metabolite sucrose ( Chen etal., 2020 ). Their orthologin Arabidopsis AT3G19940 , which is also known as STP10 , encodes a high-affinity hexose transporter ( Rottmann etal., 2016 ). These examples thus collectively demonstrate that the approach enables us to identify...”
- Plant glucose transporter structure and function
Geiger, Pflugers Archiv : European journal of physiology 2020 - “...developed pollen grain Plasma membrane Glucose, galactose, arabinose High [ 122 , 131 ] AtSTP10 At3g19940 Germinating pollen and growing pollen Plasma membrane Glucose, galactose, mannose, High [ 109 , 122 , 124 ] AtSTP11 At5g23270 Fully mature pollen and growing pollen tubes Plasma membrane Glucose,...”
- Metabolite-based genome-wide association study enables dissection of the flavonoid decoration pathway of wheat kernels
Chen, Plant biotechnology journal 2020 - “...respectively. The top hit of these candidates ( TraesCS4B01G371700 and TraesCS4D01G365800 ) in Arabidopsis ( AT3G19940 , also known as SPT10 ) encodes a highaffinity hexose transporter carrying glucose and other monosaccharides (Paulsen et al. , 2019 ; Rottmann et al. , 2016 ). Similarly, for...”
- Genome-Wide Identification and Expression Profiling of Sugar Transporter Protein (STP) Family Genes in Cabbage (Brassica oleracea var. capitata L.) Reveals their Involvement in Clubroot Disease Responses
Zhang, Genes 2019 - “...Bol014014 Scaffold000180 MF2 1551 516 56.15 6.89 33.77 101.67 0.54 cell membrane tPCK2 F AtSTP10 AT3G19940 1545 514 BoSTP10 Bol000549 Scaffold000531 MF1 1536 511 56.16 8.60 30.51 97.50 0.48 cell membrane tPCK7 Q AtSTP11 AT5G23270 1545 514 BoSTP11 Bol017091 C06 LF 1569 522 57.17 5.79 33.58...”
- Transcriptomic and proteomic approach to identify differentially expressed genes and proteins in Arabidopsis thaliana mutants lacking chloroplastic 1 and cytosolic FBPases reveals several levels of metabolic regulation
Soto-Suárez, BMC plant biology 2016 - “...: Table S4). Sugar transporter 2 (At1g07340) and three sugar transporter family proteins (At3g05155, At4g04760, At3g19940) were up-regulated in cyfbp rosettes, and only a mannitol transporter (At2g20780) was down-regulated. Finally, a carbohydrate transmembrane transporter (At1g08930) and two UDP-galactose transporters (At4g23010 and At3g59360) were up-regulated in cyfbp...”
- STP10 encodes a high-affinity monosaccharide transporter and is induced under low-glucose conditions in pollen tubes of Arabidopsis
Rottmann, Journal of experimental botany 2016 - “...microarray data furthermore indicate a rather high expression of the so far uncharacterized STP10 ( At3g19940 ) in pollen tubes. In the present paper, we describe the detailed characterization of the Arabidopsis monosaccharide transporter gene STP10 , which is expressed in pollen tubes and also in...”
- More
FGSG_10921 hypothetical protein from Fusarium graminearum PH-1
28% identity, 89% coverage
- Comparison of Fusarium graminearum Transcriptomes on Living or Dead Wheat Differentiates Substrate-Responsive and Defense-Responsive Genes
Boedi, Frontiers in microbiology 2016 - “...Furthermore, there are several genes predicted to encode sugar degrading enzymes, a putative monosaccharide transporter (FGSG_10921) or a probable CYB2lactate dehydrogenase cytochrome b2 (FGSG_01531; Table 4 ), predicted to contribute to C-2 compound and organic acid metabolism as well as lactate fermentation (register tab APup_PPup_in_planta_6 of...”
- “...Probable metalloprotease MEP1 FGSG_01468 Uncharacterized protein FGSG_01531 Probable CYB2lactate dehydrogenase cytochrome b2 FGSG_05296 Uncharacterized protein FGSG_10921 Related to monosaccharide transporter FGSG_11027 Related to N6-hydroxylysine acetyl transferase Additionally, we could identify within our experiment 30 new genes within the PP category which had not been found previously...”
AO090113000131 No description from Aspergillus oryzae RIB40
31% identity, 89% coverage
For advice on how to use these tools together, see
Interactive tools for functional annotation of bacterial genomes.
The PaperBLAST database links 793,807 different protein sequences to 1,259,118 scientific articles. Searches against EuropePMC were last performed on March 13 2025.
PaperBLAST builds a database of protein sequences that are linked
to scientific articles. These links come from automated text searches
against the articles in EuropePMC
and from manually-curated information from GeneRIF, UniProtKB/Swiss-Prot,
BRENDA,
CAZy (as made available by dbCAN),
BioLiP,
CharProtDB,
MetaCyc,
EcoCyc,
TCDB,
REBASE,
the Fitness Browser,
and a subset of the European Nucleotide Archive with the /experiment tag.
Given this database and a protein sequence query,
PaperBLAST uses protein-protein BLAST
to find similar sequences with E < 0.001.
To build the database, we query EuropePMC with locus tags, with RefSeq protein
identifiers, and with UniProt
accessions. We obtain the locus tags from RefSeq or from MicrobesOnline. We use
queries of the form "locus_tag AND genus_name" to try to ensure that
the paper is actually discussing that gene. Because EuropePMC indexes
most recent biomedical papers, even if they are not open access, some
of the links may be to papers that you cannot read or that our
computers cannot read. We query each of these identifiers that
appears in the open access part of EuropePMC, as well as every locus
tag that appears in the 500 most-referenced genomes, so that a gene
may appear in the PaperBLAST results even though none of the papers
that mention it are open access. We also incorporate text-mined links
from EuropePMC that link open access articles to UniProt or RefSeq
identifiers. (This yields some additional links because EuropePMC
uses different heuristics for their text mining than we do.)
For every article that mentions a locus tag, a RefSeq protein
identifier, or a UniProt accession, we try to select one or two
snippets of text that refer to the protein. If we cannot get access to
the full text, we try to select a snippet from the abstract, but
unfortunately, unique identifiers such as locus tags are rarely
provided in abstracts.
PaperBLAST also incorporates manually-curated protein functions:
- Proteins from NCBI's RefSeq are included if a
GeneRIF
entry links the gene to an article in
PubMed®.
GeneRIF also provides a short summary of the article's claim about the
protein, which is shown instead of a snippet.
- Proteins from Swiss-Prot (the curated part of UniProt)
are included if the curators
identified experimental evidence for the protein's function (evidence
code ECO:0000269). For these proteins, the fields of the Swiss-Prot entry that
describe the protein's function are shown (with bold headings).
- Proteins from BRENDA,
a curated database of enzymes, are included if they are linked to a paper in PubMed
and their full sequence is known.
- Every protein from the non-redundant subset of
BioLiP,
a database
of ligand-binding sites and catalytic residues in protein structures, is included. Since BioLiP itself
does not include descriptions of the proteins, those are taken from the
Protein Data Bank.
Descriptions from PDB rely on the original submitter of the
structure and cannot be updated by others, so they may be less reliable.
(For SitesBLAST and Sites on a Tree, we use a larger subset of BioLiP so that every
ligand is represented among a group of structures with similar sequences, but for
PaperBLAST, we use the non-redundant set provided by BioLiP.)
- Every protein from EcoCyc, a curated
database of the proteins in Escherichia coli K-12, is included, regardless
of whether they are characterized or not.
- Proteins from the MetaCyc metabolic pathway database
are included if they are linked to a paper in PubMed and their full sequence is known.
- Proteins from the Transport Classification Database (TCDB)
are included if they have known substrate(s), have reference(s),
and are not described as uncharacterized or putative.
(Some of the references are not visible on the PaperBLAST web site.)
- Every protein from CharProtDB,
a database of experimentally characterized protein annotations, is included.
- Proteins from the CAZy database of carbohydrate-active enzymes
are included if they are associated with an Enzyme Classification number.
Even though CAZy does not provide links from individual protein sequences to papers,
these should all be experimentally-characterized proteins.
- Proteins from the REBASE database
of restriction enzymes are included if they have known specificity.
- Every protein with an evidence-based reannotation (based on mutant phenotypes)
in the Fitness Browser is included.
- Sequence-specific transcription factors (including sigma factors and DNA-binding response regulators)
with experimentally-determined DNA binding sites from the
PRODORIC database of gene regulation in prokaryotes.
- Putative transcription factors from RegPrecise
that have manually-curated predictions for their binding sites. These predictions are based on
conserved putative regulatory sites across genomes that contain similar transcription factors,
so PaperBLAST clusters the TFs at 70% identity and retains just one member of each cluster.
- Coding sequence (CDS) features from the
European Nucleotide Archive (ENA)
are included if the /experiment tag is set (implying that there is experimental evidence for the annotation),
the nucleotide entry links to paper(s) in PubMed,
and the nucleotide entry is from the STD data class
(implying that these are targeted annotated sequences, not from shotgun sequencing).
Also, to filter out genes whose transcription or translation was detected, but whose function
was not studied, nucleotide entries or papers with more than 25 such proteins are excluded.
Descriptions from ENA rely on the original submitter of the
sequence and cannot be updated by others, so they may be less reliable.
Except for GeneRIF and ENA,
the curated entries include a short curated
description of the protein's function.
For entries from BioLiP, the protein's function may not be known beyond binding to the ligand.
Many of these entries also link to articles in PubMed.
For more information see the
PaperBLAST paper (mSystems 2017)
or the code.
You can download PaperBLAST's database here.
Changes to PaperBLAST since the paper was written:
- November 2023: incorporated PRODORIC and RegPrecise. Many PRODORIC entries were not linked to a protein sequence (no UniProt identifier), so we added this information.
- February 2023: BioLiP changed their download format. PaperBLAST now includes their non-redundant subset. SitesBLAST and Sites on a Tree use a larger non-redundant subset that ensures that every ligand is represented within each cluster. This should ensure that every binding site is represented.
- June 2022: incorporated some coding sequences from ENA with the /experiment tag.
- March 2022: incorporated BioLiP.
- April 2020: incorporated TCDB.
- April 2019: EuropePMC now returns table entries in their search results. This has expanded PaperBLAST's database, but most of the new entries are of low relevance, and the resulting snippets are often just lists of locus tags with annotations.
- February 2018: the alignment page reports the conservation of the hit's functional sites (if available from from Swiss-Prot or UniProt)
- January 2018: incorporated BRENDA.
- December 2017: incorporated MetaCyc, CharProtDB, CAZy, REBASE, and the reannotations from the Fitness Browser.
- September 2017: EuropePMC no longer returns some table entries in their search results. This has shrunk PaperBLAST's database, but has also reduced the number of low-relevance hits.
Many of these changes are described in Interactive tools for functional annotation of bacterial genomes.
PaperBLAST cannot provide snippets for many of the papers that are
published in non-open-access journals. This limitation applies even if
the paper is marked as "free" on the publisher's web site and is
available in PubmedCentral or EuropePMC. If a journal that you publish
in is marked as "secret," please consider publishing elsewhere.
Many important articles are missing from PaperBLAST, either because
the article's full text is not in EuropePMC (as for many older
articles), or because the paper does not mention a protein identifier such as a locus tag, or because of PaperBLAST's heuristics. If you notice an
article that characterizes a protein's function but is missing from
PaperBLAST, please notify the curators at UniProt
or add an entry to GeneRIF.
Entries in either of these databases will eventually be incorporated
into PaperBLAST. Note that to add an entry to UniProt, you will need
to find the UniProt identifier for the protein. If the protein is not
already in UniProt, you can ask them to create an entry. To add an
entry to GeneRIF, you will need an NCBI Gene identifier, but
unfortunately many prokaryotic proteins in RefSeq do not have
corresponding Gene identifers.
References
PaperBLAST: Text-mining papers for information about homologs.
M. N. Price and A. P. Arkin (2017). mSystems, 10.1128/mSystems.00039-17.
Europe PMC in 2017.
M. Levchenko et al (2017). Nucleic Acids Research, 10.1093/nar/gkx1005.
Gene indexing: characterization and analysis of NLM's GeneRIFs.
J. A. Mitchell et al (2003). AMIA Annu Symp Proc 2003:460-464.
UniProt: the universal protein knowledgebase.
The UniProt Consortium (2016). Nucleic Acids Research, 10.1093/nar/gkw1099.
BRENDA in 2017: new perspectives and new tools in BRENDA.
S. Placzek et al (2017). Nucleic Acids Research, 10.1093/nar/gkw952.
The EcoCyc database: reflecting new knowledge about Escherichia coli K-12.
I. M. Keeseler et al (2016). Nucleic Acids Research, 10.1093/nar/gkw1003.
The MetaCyc database of metabolic pathways and enzymes.
R. Caspi et al (2018). Nucleic Acids Research, 10.1093/nar/gkx935.
CharProtDB: a database of experimentally characterized protein annotations.
R. Madupu et al (2012). Nucleic Acids Research, 10.1093/nar/gkr1133.
The carbohydrate-active enzymes database (CAZy) in 2013.
V. Lombard et al (2014). Nucleic Acids Research, 10.1093/nar/gkt1178.
The Transporter Classification Database (TCDB): recent advances
M. H. Saier, Jr. et al (2016). Nucleic Acids Research, 10.1093/nar/gkv1103.
REBASE - a database for DNA restriction and modification: enzymes, genes and genomes.
R. J. Roberts et al (2015). Nucleic Acids Research, 10.1093/nar/gku1046.
Deep annotation of protein function across diverse bacteria from mutant phenotypes.
M. N. Price et al (2016). bioRxiv, 10.1101/072470.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory