PaperBLAST
PaperBLAST Hits for CharProtDB::CH_091271 low affinity cationic amino acid transporter 2 (Mus musculus) (657 a.a., MIPCRAVLTF...)
Show query sequence
>CharProtDB::CH_091271 low affinity cationic amino acid transporter 2 (Mus musculus)
MIPCRAVLTFARCLIRRKIVTLDSLEDSKLCRCLTTVDLIALGVGSTLGAGVYVLAGEVA
KADSGPSIVVSFLIAALASVMAGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLI
LSYVIGTSSVARAWSGTFDELLNKQIGQFFKTYFKMNYTGLAEYPDFFAVCLVLLLAGLL
SFGVKESAWVNKFFTAINILVLLFVMVAGFVKGNVANWKISEEFLKNISASAREPPSENG
TSIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLVCF
MAYFGVSAALTLMMPYYLLDEKSPLPVAFEYVRWGPAKYVVAAGSLCALSTSLLGSMFPL
PRILFAMARDGLLFRFLARVSKRQSPVAATMTAGVISAVMAFLFDLKALVDMMSIGTLMA
YSLVAACVLILRYQPGLCYEQPKYTPEKETLESCTNATLKSESQVTMLQGQGFSLRTLFS
PSALPTRQSASLVSFLVGFLAFLILGLSILTTYGVQAIARLEAWSLALLALFLVLCAAVI
LTIWRQPQNQQKVAFMVPFLPFLPAFSILVNIYLMVQLSADTWIRFSIWMALGFLIYFAY
GIRHSLEGNPRDEEDDEDAFSENINVATEEKSVMQANDHHQRNLSLPFILHEKTSEC
Running BLASTp...
Found 311 similar proteins in the literature:
TC 2.A.3.3.2 / P18581 Low affinity basic amino acid transporter (CAT2) (T-cell early activation protein (TEA)) (transports arginine, lysine and ornithine; Na+-independent) from Mus musculus (Mouse) (see 9 papers)
Slc7a2 / RF|NP_031540.2 low affinity cationic amino acid transporter 2 from Mus musculus (see paper)
100% identity, 100% coverage
- substrates: Argnine, Ornithine, lysine
E9QJY0 Solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 from Mus musculus
99% identity, 97% coverage
CTR2_MOUSE / P18581 Cationic amino acid transporter 2; CAT-2; CAT2; 20.5; Low affinity cationic amino acid transporter 2; Solute carrier family 7 member 2; T-cell early activation protein; TEA from Mus musculus (Mouse) (see 6 papers)
99% identity, 100% coverage
- function: Functions as a permease involved in the transport of the cationic amino acids (L-arginine, L-lysine, L-ornithine and L- homoarginine); the affinity for its substrates differs between isoforms created by alternative splicing (PubMed:8195186, PubMed:8385111, PubMed:9174363). May play a role in classical or alternative activation of macrophages via its role in arginine transport (PubMed:16670299).
function: [Isoform 1]: Functions as a low-affinity, high capacity permease involved in the transport of the cationic amino acids (L- arginine, L-lysine, L-ornithine and L-homoarginine).
function: [Isoform 2]: Functions as a permease that mediates the transport of the cationic amino acids (L-arginine, L-lysine, L- ornithine and L-homoarginine). Shows a much higher affinity for L- arginine than isoform 1.
catalytic activity: [Isoform 1]: L-arginine(in) = L-arginine(out) (RHEA:32143)
catalytic activity: [Isoform 2]: L-arginine(in) = L-arginine(out) (RHEA:32143)
catalytic activity: L-lysine(in) = L-lysine(out) (RHEA:70935)
catalytic activity: L-ornithine(in) = L-ornithine(out) (RHEA:71199)
catalytic activity: L-homoarginine(in) = L-homoarginine(out) (RHEA:71203)
disruption phenotype: Intracellular polyamine levels are reduced in hepatocytes. Infection of knockout mice with parasite P.berghei (ANKA strain) sporozoites results in a reduction in the parasite load in the liver compared to wild type mice. - Extracellular vesicles from microglial cells activated by abnormal heparan sulfate oligosaccharides from Sanfilippo patients impair neuronal dendritic arborization
Dias, Molecular medicine (Cambridge, Mass.) 2024 - “...GO:0043543, Protein palmitoylation; GO:0018345, Regulation of postsynaptic membrane neurotransmitter receptor levels; GO:0099072 Slc7a2 0,681 1,175 P18581 Cationic amino acid transporter 2 Carboxylic acid transmembrane transport; GO:1905039, Innate immune response; GO:0045087, Regulation of leukocyte cellcell adhesion; GO:1903037 Dip2b 0,287 1,285 Q3UH60 Disco-interacting protein 2 homolog B Mitochondrial...”
NP_001038205 cationic amino acid transporter 2 isoform 2 from Mus musculus
96% identity, 100% coverage
- Elevated SLC7A2 expression is associated with an abnormal neuroinflammatory response and nitrosative stress in Huntington's disease.
Gaudet, Journal of neuroinflammation 2024 - GeneRIF: Elevated SLC7A2 expression is associated with an abnormal neuroinflammatory response and nitrosative stress in Huntington's disease.
- Integrated Amino Acids and Transcriptome Analysis Reveals Arginine Transporter SLC7A2 Is a Novel Regulator of Myogenic Differentiation.
Huang, International journal of molecular sciences 2023 - GeneRIF: Integrated Amino Acids and Transcriptome Analysis Reveals Arginine Transporter SLC7A2 Is a Novel Regulator of Myogenic Differentiation.
- SLC3A2 and SLC7A2 Mediate the Exogenous Putrescine-Induced Adipocyte Differentiation.
Eom, Molecules and cells 2022 - GeneRIF: SLC3A2 and SLC7A2 Mediate the Exogenous Putrescine-Induced Adipocyte Differentiation.
- Molecular Determinants for Nitric Oxide Regulation of the Murine Cationic Amino Acid Transporter CAT-2A.
Zheng, Biochemistry 2020 (PubMed)- GeneRIF: Molecular Determinants for Nitric Oxide Regulation of the Murine Cationic Amino Acid Transporter CAT-2A.
- Loss of solute carrier family 7 member 2 exacerbates inflammation-associated colon tumorigenesis.
Coburn, Oncogene 2019 - GeneRIF: data reveal that SLC7A2 has a significant role in the protection from colitis-associated carcinogenesis (CAC) in the setting of chronic colitis, and suggest that the decreased SLC7A2 in inflammatory bowel disease (IBD) may contribute to CAC risk.
- Deficiency of cationic amino acid transporter-2 protects mice from hyperoxia-induced lung injury.
Jin, American journal of physiology. Lung cellular and molecular physiology 2019 - GeneRIF: In wild-type mice exposed to hyperoxia, the exhaled nitric oxide (exNO) was twofold greater than in wild-type mice exposed to normoxia ( P < 0.005), whereas in slc7a2(-/-) mice there was no significant difference between exNO in animals exposed to hyperoxia or normoxia ( P = 0.95). These results are consistent with our hypothesis that lack of CAT-2 protects mice from acute lung injury.
- Characterisation of genes differentially expressed in macrophages by virulent and attenuated Mycobacterium tuberculosis through RNA-Seq analysis.
Lee, Scientific reports 2019 - GeneRIF: Characterisation of genes differentially expressed in macrophages by virulent and attenuated Mycobacterium tuberculosis through RNA-Seq analysis.
- MCD diet-induced steatohepatitis is associated with alterations in asymmetric dimethylarginine (ADMA) and its transporters.
Di, Molecular and cellular biochemistry 2016 (PubMed)- GeneRIF: A time-dependent decrease in serum and tissue ADMA and increase in mRNA expression of DDAH-1 and PRMT-1 as well as higher rates of mRNA expression of CAT-1 and lower rates of CAT-2A and CAT-2B were found after 8-week MCD diet.
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E1B968 Solute carrier family 7 member 2 from Bos taurus
92% identity, 100% coverage
XP_005226082 cationic amino acid transporter 2 isoform X1 from Bos taurus
88% identity, 100% coverage
XP_014960059 cationic amino acid transporter 2 isoform X6 from Ovis aries
89% identity, 100% coverage
CTR2_HUMAN / P52569 Cationic amino acid transporter 2; CAT-2; CAT2; Low affinity cationic amino acid transporter 2; Solute carrier family 7 member 2 from Homo sapiens (Human) (see 3 papers)
TC 2.A.3.3.8 / P52569 Low affinity cationic amino acid transporter 2 (CAT-2) (CAT2) (Solute carrier family 7 member 2) from Homo sapiens (see 6 papers)
XP_016869235 cationic amino acid transporter 2 isoform X1 from Homo sapiens
88% identity, 100% coverage
- function: Functions as a permease involved in the transport of the cationic amino acids (L-arginine, L-lysine, L-ornithine and L- homoarginine); the affinity for its substrates differs between isoforms created by alternative splicing (PubMed:28684763, PubMed:9174363). May play a role in classical or alternative activation of macrophages via its role in arginine transport (By similarity).
function: [Isoform 1]: Functions as a permease that mediates the transport of the cationic amino acids (L-arginine, L-lysine, L- ornithine and L-homoarginine). Shows a much higher affinity for L- arginine and L-homoarginine than isoform 2.
function: [Isoform 2]: Functions as a low-affinity, high capacity permease involved in the transport of the cationic amino acids (L- arginine, L-lysine, L-ornithine and L-homoarginine).
catalytic activity: [Isoform 1]: L-arginine(in) = L-arginine(out) (RHEA:32143)
catalytic activity: [Isoform 2]: L-arginine(in) = L-arginine(out) (RHEA:32143)
catalytic activity: L-lysine(in) = L-lysine(out) (RHEA:70935)
catalytic activity: L-ornithine(in) = L-ornithine(out) (RHEA:71199)
catalytic activity: [Isoform 1]: L-homoarginine(in) = L-homoarginine(out) (RHEA:71203)
catalytic activity: [Isoform 2]: L-homoarginine(in) = L-homoarginine(out) (RHEA:71203) - substrates: Amino acids
- System, Method and Software for Calculation of a Cannabis Drug Efficiency Index for the Reduction of Inflammation.
Borisov, International journal of molecular sciences 2020 - “...SERPINC1 Antithrombin-III UniProtKB: P36955 SERPINF1 Pigment epithelium-derived factor UniProtKB: Q86VZ5 SGMS1 Phosphatidylcholine:ceramide cholinephosphotransferase 1 UniProtKB: P52569 SLC7A2 Cationic amino acid transporter 2 UniProtKB: P52569 SLC7A2 Cationic amino acid transporter 2 UniProtKB: Q15797 SMAD1 Mothers against decapentaplegic homolog 1 UniProtKB: P84022 SMAD3 Mothers against decapentaplegic homolog 3...”
- LocText: relation extraction of protein localizations to assist database curation
Cejuela, BMC bioinformatics 2018 - “...the tonoplast in transformed Arabidopsis protoplasts, PMID (PubMed Identifier) 15377779, the relationship of CAT2 (UniProtKB: P52569) localized to tonoplast (GO:0009705) must be established. Most existing GO annotation methods either coarsely associate all pairs of entities that are co-mentioned in a same sentence or otherwise aggregate the...”
- THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Transporters
Alexander, British journal of pharmacology 2017 - “...2 Systematic nomenclature SLC7A1 SLC7A2 SLC7A3 SLC7A5 SLC7A8 HGNC, UniProt SLC7A1 , P30825 SLC7A2 , P52569 SLC7A3 , Q8WY07 SLC7A5 , Q01650 SLC7A8 , Q9UHI5 Common abreviation CAT1 CAT2 CAT3 LAT1 LAT2 Substrates Lornithine , Larginine , Llysine , Lhistidine Lornithine , Larginine , Llysine ,...”
- The Concise Guide to PHARMACOLOGY 2015/16: Transporters
Alexander, British journal of pharmacology 2015 - “...SLC7A3 SLC7A5 Common abreviation CAT1 CAT2 CAT3 LAT1 HGNC, UniProt SLC7A1 , P30825 SLC7A2 , P52569 SLC7A3 , Q8WY07 SLC7A5 , Q01650 Substrates Lornithine , Larginine , Llysine , Lhistidine Lornithine , Larginine , Llysine , Lhistidine Lornithine , Larginine , Llysine Nomenclature Ltype amino acid...”
- The Concise Guide to PHARMACOLOGY 2013/14: transporters
Alexander, British journal of pharmacology 2013 - “...SLC7A2 SLC7A3 SLC7A4 SLC7A14 Common abbreviation CAT1 CAT2 CAT3 CAT4 HGNC, UniProt SLC7A1, P30825 SLC7A2, P52569 SLC7A3, Q8WY07 SLC7A4, O43246 SLC7A14, Q8TBB6 Substrates L-arginine, L-lysine, L-ornithine, L-histidine L-arginine, L-lysine, L-ornithine, L-histidine L-arginine, L-lysine, L-ornithine Glycoprotein-associated amino acid transporters are 12 TM proteins, which heterodimerize with members...”
- Elevated SLC7A2 expression is associated with an abnormal neuroinflammatory response and nitrosative stress in Huntington's disease.
Gaudet, Journal of neuroinflammation 2024 - GeneRIF: Elevated SLC7A2 expression is associated with an abnormal neuroinflammatory response and nitrosative stress in Huntington's disease.
- SLC7A2-Mediated Lysine Catabolism Inhibits Immunosuppression in Triple Negative Breast Cancer.
Sun, Critical reviews in eukaryotic gene expression 2024 (PubMed)- GeneRIF: SLC7A2-Mediated Lysine Catabolism Inhibits Immunosuppression in Triple Negative Breast Cancer.
- Lower SLC7A2 expression is associated with enhanced multidrug resistance, less immune infiltrates and worse prognosis of NSCLC.
Jiang, Cell communication and signaling : CCS 2023 - GeneRIF: Lower SLC7A2 expression is associated with enhanced multidrug resistance, less immune infiltrates and worse prognosis of NSCLC.
- Integrated Amino Acids and Transcriptome Analysis Reveals Arginine Transporter SLC7A2 Is a Novel Regulator of Myogenic Differentiation.
Huang, International journal of molecular sciences 2023 - GeneRIF: Integrated Amino Acids and Transcriptome Analysis Reveals Arginine Transporter SLC7A2 Is a Novel Regulator of Myogenic Differentiation.
- SLC7A2 deficiency promotes hepatocellular carcinoma progression by enhancing recruitment of myeloid-derived suppressors cells.
Xia, Cell death & disease 2021 - GeneRIF: SLC7A2 deficiency promotes hepatocellular carcinoma progression by enhancing recruitment of myeloid-derived suppressors cells.
- Human cationic amino acid transporters are not affected by direct nitros(yl)ation.
Hobbach, Amino acids 2020 (PubMed)- GeneRIF: Human cationic amino acid transporters are not affected by direct nitros(yl)ation.
- SLC7A2 serves as a potential biomarker and therapeutic target for ovarian cancer.
Sun, Aging 2020 - GeneRIF: SLC7A2 serves as a potential biomarker and therapeutic target for ovarian cancer.
- Genetic variation in SLC7A2 interacts with calcium and magnesium intakes in modulating the risk of colorectal polyps.
Sun, The Journal of nutritional biochemistry 2017 - GeneRIF: genetic association studies in population in Tennessee: Data suggest that an SNP in SLC7A2 (rs2720574) is associated with response to dietary calcium and magnesium in prevention of colorectal polyps and colorectal ademonas.
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CTR2_CHICK / B3TP03 Cationic amino acid transporter 2; CAT-2; CAT2; cCAT-2; Low affinity cationic amino acid transporter 2; Solute carrier family 7 member 2 from Gallus gallus (Chicken) (see paper)
78% identity, 100% coverage
- function: Low-affinity, high capacity permease involved in the transport of the cationic amino acids (L-arginine, L-lysine, L- ornithine and L-homoarginine).
catalytic activity: L-arginine(in) = L-arginine(out) (RHEA:32143)
catalytic activity: L-lysine(in) = L-lysine(out) (RHEA:70935)
catalytic activity: L-ornithine(in) = L-ornithine(out) (RHEA:71199)
catalytic activity: L-homoarginine(in) = L-homoarginine(out) (RHEA:71203)
E2QU34 Cationic amino acid transporter 1 from Canis lupus familiaris
60% identity, 92% coverage
XP_683623 high affinity cationic amino acid transporter 1 isoform X1 from Danio rerio
58% identity, 97% coverage
XP_069905166 high affinity cationic amino acid transporter 1 from Oryctolagus cuniculus
60% identity, 94% coverage
B2R728 cDNA, FLJ93255, highly similar to Homo sapiens solute carrier family 7 (cationic amino acidtransporter, y+ system), member 1 (SLC7A1), mRNA from Homo sapiens
60% identity, 92% coverage
CTR1_HUMAN / P30825 High affinity cationic amino acid transporter 1; CAT-1; CAT1; Ecotropic retroviral leukemia receptor homolog; Ecotropic retrovirus receptor homolog; Solute carrier family 7 member 1; System Y+ basic amino acid transporter from Homo sapiens (Human) (see 4 papers)
TC 2.A.3.3.9 / P30825 High affinity cationic amino acid transporter 1 (CAT-1) (CAT1) (Ecotropic retroviral leukemia receptor homologue) (Ecotropic retrovirus receptor homologue) (ERR) (Solute carrier family 7 member 1) (System Y+ basic amino acid transporter) from Homo sapiens (see 6 papers)
60% identity, 92% coverage
- function: High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues.
catalytic activity: L-arginine(in) = L-arginine(out) (RHEA:32143)
catalytic activity: L-lysine(in) = L-lysine(out) (RHEA:70935)
catalytic activity: L-ornithine(in) = L-ornithine(out) (RHEA:71199)
catalytic activity: L-homoarginine(in) = L-homoarginine(out) (RHEA:71203)
subunit: Interacts with TM4SF5; the interaction is negatively regulated by arginine (PubMed:30956113). Forms tissue-specific complexes with ASL, ASS1 and nitric oxide synthase NOS1 or NOS3; the complex regulates cell-autonomous L-arginine synthesis and citrulline recycling while channeling extracellular L-arginine to nitric oxide synthesis pathway (By similarity). - substrates: Amino acids
- Isolation method of brain microvessels from small frozen human brain tissue for blood-brain barrier protein expression analysis.
Ogata, Fluids and barriers of the CNS 2024 - “...- SLC6A12 P48065 Detected only in Bcap - SLC2A1 (GLUT1) P11166 122 4.66E-06 SLC7A1 (ATRC1) P30825 36.7 8.42E-05 SLC16A1 (MCT1) P53985 15.8 5.55E-02 SLC5A6 (SMVT) Q9Y289 15.3 9.17E-03 SLC9A3R2 (NHERF2) Q15599 12.0 3.42E-05 SLC38A3 (SNAT3) Q99624 7.41 9.82E-04 SLC7A5 (LAT1) Q01650 5.92 6.38E-05 SLC30A1 (ZNT1) Q9Y6M5...”
- Surfaceome Profiling of Cell Lines and Patient-Derived Xenografts Confirm FGFR4, NCAM1, CD276, and Highlight AGRL2, JAM3, and L1CAM as Surface Targets for Rhabdomyosarcoma
Timpanaro, International journal of molecular sciences 2023 - “...PE = 1 SV = 2 3.58 10 8 6.30 10 8 0.817 18 82 P30825 SLC7A1 High affinity cationic amino acid transporter 1 OS = Homo sapiens OX = 9606 GN = SLC7A1 PE = 1 SV = 1 1.97 10 8 7.64 10 7...”
- Neurodevelopmental signatures of narcotic and neuropsychiatric risk factors in 3D human-derived forebrain organoids.
Notaras, Molecular psychiatry 2021 - “...Dehydrogenase E1 Component DHKTD1, Mitochonondrial Q96HY7 0.018748869 SLC7A1 High Affinity Cationic Amino Acid Transporter 1 P30825 0.021172737 PIK3C2B Phosphatidylinositol 4-Phosphate 3-Kinase C2 Domain-Containing Subunit Beta O00750 0.021899148 SORBS1 Sorbin and SH3 Domain-Containing Protein 1 Q9BX66-4 0.024998617 HSPA9 Stress-70 Protein, Mitochondrial P38646 0.027136132 CCDC47 Coiled-Coil domain-Containing Protein...”
- Humoral Immunity Profiling of Subjects with Myalgic Encephalomyelitis Using a Random Peptide Microarray Differentiates Cases from Controls with High Specificity and Sensitivity
Singh, Molecular neurobiology 2018 - “...715 119.7 7 NP_060868 CACNA2D3 Calcium voltage-gated channel auxiliary subunit alpha2delta 3 1091 121.2 5 P30825 SLC7A1 Solute carrier family 7 member 1 629 125.8 4 NP_004557 PFKFB3 6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 520 130 4 XP_011509718 ACOXL Acyl-CoA oxidase-like 547 136.8 Previous studies have proposed that HERV elements...”
- Label-free Proteomic Analysis of Exosomes Derived from Inducible Hepatitis B Virus-Replicating HepAD38 Cell Line
Jia, Molecular & cellular proteomics : MCP 2017 - “...Q9Y265 SARS QARS MAN2B1 LEPRE1 RUVBL1 Q9UGQ3 SLC2A6 P30825 P53618 Q9Y678 Q96RQ1 SLC7A1 COPB1 COPG1 ERGIC2 O15431 O14980 SLC31A1 XPO1 O00400 P48723 Q07021...”
- THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Transporters
Alexander, British journal of pharmacology 2017 - “...amino acid transporter 2 Systematic nomenclature SLC7A1 SLC7A2 SLC7A3 SLC7A5 SLC7A8 HGNC, UniProt SLC7A1 , P30825 SLC7A2 , P52569 SLC7A3 , Q8WY07 SLC7A5 , Q01650 SLC7A8 , Q9UHI5 Common abreviation CAT1 CAT2 CAT3 LAT1 LAT2 Substrates Lornithine , Larginine , Llysine , Lhistidine Lornithine , Larginine...”
- Glycomic and sialoproteomic data of gastric carcinoma cells overexpressing ST3GAL4.
Mereiter, Data in brief 2016 - “...P21589 5-nucleotidase LDNdeYSTQELGK N333 1.67 0.0479 E P26006 Integrin alpha-3 ELAVPDGYTNdeRTGAVYLCPLTAHK N86 2.68 0.0433 AM P30825 High affinity cationic amino acid transporter 1 LCLNNdeDTK N235 3.48 0.0297 TT LCLNdeNdeDTK N234 3.01 0.0342 P35613 Basigin ALMNdeGSESR N268 2.91 0.0342 P P42892 Endothelin-converting enzyme 1 NdeSSVEAFK N632 1.89...”
- The Concise Guide to PHARMACOLOGY 2015/16: Transporters
Alexander, British journal of pharmacology 2015 - “...nomenclature SLC7A1 SLC7A2 SLC7A3 SLC7A5 Common abreviation CAT1 CAT2 CAT3 LAT1 HGNC, UniProt SLC7A1 , P30825 SLC7A2 , P52569 SLC7A3 , Q8WY07 SLC7A5 , Q01650 Substrates Lornithine , Larginine , Llysine , Lhistidine Lornithine , Larginine , Llysine , Lhistidine Lornithine , Larginine , Llysine Nomenclature...”
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Q8VIA9 Ecotropic retrovirus receptor from Rattus norvegicus
60% identity, 92% coverage
CTR1_MOUSE / Q09143 High affinity cationic amino acid transporter 1; CAT-1; CAT1; Ecotropic retroviral leukemia receptor; Ecotropic retrovirus receptor; ERR; EcoR; Solute carrier family 7 member 1; System Y+ basic amino acid transporter from Mus musculus (Mouse) (see 7 papers)
TC 2.A.3.3.1 / Q09143 System Y+ high affinity basic amino acid transporter (CAT1) (ecotropic retrovival leukemia virus receptor (ERR)) (transports arginine, lysine and ornithine; Na+-independent) from Mus musculus (Mouse) (see 2 papers)
Slc7a1 / RF|NP_031539.3 high affinity cationic amino acid transporter 1 from Mus musculus
NP_031539 high affinity cationic amino acid transporter 1 from Mus musculus
60% identity, 92% coverage
- function: High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues.
function: (Microbial infection) Acts as a receptor for the ecotropic murine retroviral leukemia virus.
catalytic activity: L-arginine(in) = L-arginine(out) (RHEA:32143)
catalytic activity: L-lysine(in) = L-lysine(out) (RHEA:70935)
catalytic activity: L-ornithine(in) = L-ornithine(out) (RHEA:71199)
catalytic activity: L-homoarginine(in) = L-homoarginine(out) (RHEA:71203)
subunit: Interacts with TM4SF5; the interaction is negatively regulated by arginine (By similarity). Forms tissue-specific complexes with ASL, ASS1 and nitric oxide synthase NOS1 or NOS3; the complex regulates cell-autonomous L-arginine synthesis and citrulline recycling while channeling extracellular L-arginine to nitric oxide synthesis pathway (PubMed:22081021). - substrates: Arginine, Ornithine, lysine
- The solute carrier SLC7A1 may act as a protein transporter at the blood-brain barrier.
Kurtyka, European journal of cell biology 2024 (PubMed)- GeneRIF: The solute carrier SLC7A1 may act as a protein transporter at the blood-brain barrier.
- Cationic amino acid transporter-1 (CAT-1) promotes fibroblast-like synoviocyte proliferation and cytokine secretion by taking up L-arginine in rheumatoid arthritis.
Lu, Arthritis research & therapy 2022 - GeneRIF: Cationic amino acid transporter-1 (CAT-1) promotes fibroblast-like synoviocyte proliferation and cytokine secretion by taking up L-arginine in rheumatoid arthritis.
- Endothelial-specific overexpression of cationic amino acid transporter-1 prevents loss of kidney function in heart failure.
Giam, Clinical science (London, England : 1979) 2020 (PubMed)- GeneRIF: Endothelial-specific overexpression of cationic amino acid transporter-1 prevents loss of kidney function in heart failure.
- MCD diet-induced steatohepatitis is associated with alterations in asymmetric dimethylarginine (ADMA) and its transporters.
Di, Molecular and cellular biochemistry 2016 (PubMed)- GeneRIF: A time-dependent decrease in serum and tissue ADMA and increase in mRNA expression of DDAH-1 and PRMT-1 as well as higher rates of mRNA expression of CAT-1 and lower rates of CAT-2A and CAT-2B were found after 8-week MCD diet.
- Endothelial cationic amino acid transporter-1 overexpression blunts the effects of oxidative stress on pressor responses to behavioural stress in mice.
Rajapakse, Clinical and experimental pharmacology & physiology 2014 (PubMed)- GeneRIF: Endothelial CAT-1 overexpression can counter the ability of oxidative stress.
- Nitric oxide signalling pathway in Duchenne muscular dystrophy mice: up-regulation of L-arginine transporters.
Ramachandran, The Biochemical journal 2013 - GeneRIF: L-argine transporters CAT-1 and CAT-2A expression and function are significantly increased in Duchenne muscular dystrophy mice.
- GRB2 interaction with the ecotropic murine leukemia virus receptor, mCAT-1, controls virus entry and is stimulated by virus binding.
Chen, Journal of virology 2012 - GeneRIF: findings suggest a novel role for GRB2 in ecotropic MLV entry and infection by facilitating mCAT-1 trafficking
- A bifunctional intronic element regulates the expression of the arginine/lysine transporter Cat-1 via mechanisms involving the purine-rich element binding protein A (Pur alpha).
Huang, The Journal of biological chemistry 2009 - GeneRIF: analysis of how a bifunctional intronic element regulates the expression of the arginine/lysine transporter Cat-1 via mechanisms involving the purine-rich element binding protein A (Pur alpha)
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- A multi-hierarchical approach reveals d-serine as a hidden substrate of sodium-coupled monocarboxylate transporters.
Wiriyasermkul, eLife 2024 - “...p-Value of 8 hr IRI/ sham Peptides Score Mascot Abundance in sham * Increased Slc7a1/Cat1 Q09143 0.8 0.12 1.3 0.01 1 131 2.6E+06 Slc1a5/Asct2 P51912 0.4 0.10 0.7 0.09 4 767 1.5E+07 Decreased Slc36a1/Pat1 Q8K4D3 1.2 0.08 1.0 0.12 3 103 5.4E+06 Slc2a5/Glut5 Q9WV38 1.2 0.01...”
- NEAT1 inhibits the angiogenic activity of cerebral arterial endothelial cells by inducing the M1 polarization of microglia through the AMPK signaling pathway.
Chen, Cellular & molecular biology letters 2024 - “...SETD7 4.29 Q8VDV8 Mitd1 MIT domain-containing protein 1 4.09 Q08857 Cd36 Platelet glycoprotein 4 4.05 Q09143 Slc7a1 High affinity cationic amino acid transporter 1 3.83 Q8BP40 Acp6 Lysophosphatidic acid phosphatase type 6 3.79 Q69ZQ2 Isy1 Pre-mRNA-splicing factor ISY1 homolog 3.48 Q9ET26 Rnf114 E3 ubiquitin-protein ligase RNF114...”
- Proteomic Analysis of Protective Effects of Dl-3-n-Butylphthalide against mpp + -Induced Toxicity via downregulating P53 pathway in N2A Cells
Zhao, Proteome science 2023 - “...domain-containing protein 1 0.027175 Q14B01 Rnf113a2 Ring finger protein 113A2 0.000267 Q0PD20 Rab34 Rab34 0.023811 Q09143 Slc7a1 High affinity cationic amino acid transporter 1 0.032001 Q08509 Eps8 Epidermal growth factor receptor kinase substrate 8 0.006738 Q07813 Bax Apoptosis regulator BAX 0.018148 Q05915 Gch1 GTP cyclohydrolase 1...”
- TMT-Based Quantitative Proteomic Analysis Reveals the Effect of Bone Marrow Derived Mesenchymal Stem Cell on Hair Follicle Regeneration
Zhang, Frontiers in pharmacology 2021 - “...L-dopachrome tautomerase Dct 4.457 1.73E-05 3.564 1.64E-04 Q9QXD6 Fructose-1,6-bisphosphatase 1 Fbp1 4.31 1.53E-03 2.421 4.01E-02 Q09143 High affinity cationic amino acid transporter 1 Slc7a1 3.674 1.24E-02 2.487 3.50E-02 P02798 Metallothionein-2 Mt2 3.479 1.81E-04 2.281 8.23E-03 Q8R100 Calcium homeostasis modulator protein 5 Calhm5 3.469 2.35E-02 2.506 4.53E-02...”
- Efficient isolation of brain capillary from a single frozen mouse brain for protein expression analysis.
Ogata, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2021 - Regulation of the V-ATPase along the endocytic pathway occurs through reversible subunit association and membrane localization.
Lafourcade, PloS one 2008 - “...2 40 O55143 endoplasmic reticulum calcium ATPase 2 Ion transport 107.98 114784 3.45 2 41 Q09143 High affinity cationic amino acid transporter 1 Ion transport 98.32 67048 3.94 2 42 Q91VS7 Microsomal glutathione S-transferase 1 Ion transport 83.61 17409 7.59 1 43 Q8VDN2 Na(+)/K(+) ATPase alpha-1...”
CTR1_RAT / P30823 High affinity cationic amino acid transporter 1; CAT-1; CAT1; Ecotropic retroviral leukemia receptor; Ecotropic retrovirus receptor; EcoR; Solute carrier family 7 member 1; System Y+ basic amino acid transporter from Rattus norvegicus (Rat) (see paper)
60% identity, 92% coverage
- function: High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues.
function: (Microbial infection) Acts as a receptor for the ecotropic murine retroviral leukemia virus.
catalytic activity: L-arginine(in) = L-arginine(out) (RHEA:32143)
catalytic activity: L-lysine(in) = L-lysine(out) (RHEA:70935)
catalytic activity: L-ornithine(in) = L-ornithine(out) (RHEA:71199)
catalytic activity: L-homoarginine(in) = L-homoarginine(out) (RHEA:71203)
subunit: Interacts with TM4SF5; the interaction is negatively regulated by arginine (By similarity). Forms tissue-specific complexes with ASL, ASS1 and nitric oxide synthase NOS1 or NOS3; the complex regulates cell-autonomous L-arginine synthesis and citrulline recycling while channeling extracellular L-arginine to nitric oxide synthesis pathway (By similarity). - Proteomic analysis of immature rat pups brain in response to hypoxia and ischemia challenge.
Yang, International journal of clinical and experimental pathology 2014
Q3UTL4 Cationic amino acid transporter C-terminal domain-containing protein from Mus musculus
60% identity, 92% coverage
NP_001012631 high affinity cationic amino acid transporter 1 from Sus scrofa
60% identity, 92% coverage
- Transmissible gastroenteritis virus infection decreases arginine uptake by downregulating CAT-1 expression.
Xia, Veterinary research 2018 - GeneRIF: High performance liquid chromatography (HPLC) analyses showed that Transmissible gastroenteritis virus infection leads to reduced arginine uptake at 48 hours post-infection (hpi). Expression of cationic amino acid transporter 1 (CAT-1) was attenuated as well.
- Dietary arginine supplementation enhances intestinal expression of SLC7A7 and SLC7A1 and ameliorates growth depression in mycotoxin-challenged pigs.
Yin, Amino acids 2014 (PubMed)- GeneRIF: Arginine supplementation enhances small intestinal expression of SLC7A7 and SLC7A1.
- Expression of cationic amino acid transporters, carcass traits, and performance of growing pigs fed low-protein amino acid-supplemented versus high protein diets.
Morales, Genetics and molecular research : GMR 2013 (PubMed)- GeneRIF: Changes in the expression of b(0,+) and CAT-1 in pigs fed on amino acid supplemented versus high proteins diets.
- Expression profiles of miRNA-122 and its target CAT1 in minipigs (Sus scrofa) fed a high-cholesterol diet.
Cirera, Comparative medicine 2010 - GeneRIF: Data show that in minipigs, increased weight and cholesterol resulting from a high-cholesterol diet are correlated with a decrease in the expression of miRNA-122, and that gene expression levels of CAT1 do not differ between groups.
- Molecular cloning, characterization, and chromosomal assignment of porcine cationic amino acid transporter-1.
Cui, Genomics 2005 (PubMed)- GeneRIF: Radiation hybrid mapping data indicate that the porcine SLC7A1 maps to the distal end of the short arm of pig chromosome 11
NP_001007330 solute carrier family 7, member 3 from Danio rerio
55% identity, 95% coverage
CTR3_HUMAN / Q8WY07 Cationic amino acid transporter 3; CAT-3; CAT3; Cationic amino acid transporter y+; Solute carrier family 7 member 3 from Homo sapiens (Human) (see paper)
TC 2.A.3.3.10 / Q8WY07 Cationic amino acid transporter 3 (CAT-3) (CAT3) (Cationic amino acid transporter y+) (Solute carrier family 7 member 3) from Homo sapiens (see 5 papers)
NP_001041629 cationic amino acid transporter 3 from Homo sapiens
57% identity, 92% coverage
- function: Uniporter that mediates the uptake of cationic L-amino acids such as L-arginine, L-lysine and L-ornithine (PubMed:11591158). The transport is sodium ions- and pH-independent, moderately trans- stimulated and is mediated by passive diffusion (PubMed:11591158).
catalytic activity: L-arginine(in) = L-arginine(out) (RHEA:32143)
catalytic activity: L-lysine(in) = L-lysine(out) (RHEA:70935)
catalytic activity: L-ornithine(in) = L-ornithine(out) (RHEA:71199) - substrates: Amino acids
- Comparative Bioinformatic Analysis of the Proteomes of Rabbit and Human Sex Chromosomes
Pinto-Pinho, Animals : an open access journal from MDPI 2024 - “...acid transporter B(0+) TM PM P48029 SLC6A8 Sodium- and chloride-dependent creatine transporter 1 TM PM Q8WY07 SLC7A3 Cationic amino acid transporter 3 TM PM Q92581 SLC9A6 Sodium/hydrogen exchanger 6 SP+TM PM Q96T83 SLC9A7 Sodium/hydrogen exchanger 7 SP+TM PM Q9H156 SLITRK2 SLIT- and NTRK-like protein 2 SP+TM...”
- The Expression of Rab8, Ezrin, Radixin and Moesin in the Ciliary Body of Cynomolgus Monkeys.
Tanabe, Juntendo Iji zasshi = Juntendo medical journal 2022 - “...0.00 1 37 Catenin alpha-1 P35221 100008.6 2.00 1 38 Cationic amino acid transporter 3 Q8WY07 67125.6 1.90 2 39 CD59 glycoprotein P13987 14167.8 8.60 4 40 CD9 antigen P21926 25399.0 5.30 2 41 Centromere protein C 1 Q03188 106860.4 1.30 1 42 Citrate synthase, mitochondrial...”
- THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Transporters
Alexander, British journal of pharmacology 2017 - “...SLC7A1 SLC7A2 SLC7A3 SLC7A5 SLC7A8 HGNC, UniProt SLC7A1 , P30825 SLC7A2 , P52569 SLC7A3 , Q8WY07 SLC7A5 , Q01650 SLC7A8 , Q9UHI5 Common abreviation CAT1 CAT2 CAT3 LAT1 LAT2 Substrates Lornithine , Larginine , Llysine , Lhistidine Lornithine , Larginine , Llysine , Lhistidine Lornithine ,...”
- The Concise Guide to PHARMACOLOGY 2015/16: Transporters
Alexander, British journal of pharmacology 2015 - “...abreviation CAT1 CAT2 CAT3 LAT1 HGNC, UniProt SLC7A1 , P30825 SLC7A2 , P52569 SLC7A3 , Q8WY07 SLC7A5 , Q01650 Substrates Lornithine , Larginine , Llysine , Lhistidine Lornithine , Larginine , Llysine , Lhistidine Lornithine , Larginine , Llysine Nomenclature Ltype amino acid transporter 2 y+L...”
- Comprehensive quantitative comparison of the membrane proteome, phosphoproteome, and sialiome of human embryonic and neural stem cells
Melo-Braga, Molecular & cellular proteomics : MCP 2014 - “...Level ID Protein Description Protein Ratio Q9BV40 Q8WY07 Q14126 Q96SQ9 Q10589 Q15833 P20339 P21709 Q01650 P11169 Q96QD8 P20337 P17302 Q14571 P08195...”
- The Concise Guide to PHARMACOLOGY 2013/14: transporters
Alexander, British journal of pharmacology 2013 - “...SLC7A4 SLC7A14 Common abbreviation CAT1 CAT2 CAT3 CAT4 HGNC, UniProt SLC7A1, P30825 SLC7A2, P52569 SLC7A3, Q8WY07 SLC7A4, O43246 SLC7A14, Q8TBB6 Substrates L-arginine, L-lysine, L-ornithine, L-histidine L-arginine, L-lysine, L-ornithine, L-histidine L-arginine, L-lysine, L-ornithine Glycoprotein-associated amino acid transporters are 12 TM proteins, which heterodimerize with members of the...”
- Hypomorphic variants of cationic amino acid transporter 3 in males with autism spectrum disorders.
Nava, Amino acids 2015 - GeneRIF: rare hypomorphic variants of SLC7A3 exist in male individuals, SLC7A3 variants possibly contribute to the etiology of autism spectrum disorders in male subjects in association with other genetic factors
- Genetic ablation of solute carrier family 7a3a leads to hepatic steatosis in zebrafish during fasting.
Gu, Hepatology (Baltimore, Md.) 2014 (PubMed)- GeneRIF: knockdown impaired AMPK-PPAR-alpha signaling and resulted in lipid accumulation under glucose starvation in liver cells
- Differential topochemistry of three cationic amino acid transporter proteins, hCAT1, hCAT2 and hCAT3, in the adult human brain.
Jäger, Amino acids 2013 (PubMed)- GeneRIF: CAT1, CAT2, and CAT3 localized in adult brains but with uneven distribution.
- Activation of classical protein kinase C reduces the expression of human cationic amino acid transporter 3 (hCAT-3) in the plasma membrane.
Rotmann, The Biochemical journal 2006 - GeneRIF: It is concluded that similar to hCAT-1, hCAT-3 activity is decreased by PKC via reduction of transporter molecules in the plasma membrane.
- Monovalent cation conductance in Xenopus laevis oocytes expressing hCAT-3.
Gilles, Biochimica et biophysica acta 2005 (PubMed)- GeneRIF: is concluded that hCAT-3 is a passive transport system that conducts monovalent cations including L-Arg.
G1SZJ1 Solute carrier family 7 member 3 from Oryctolagus cuniculus
57% identity, 92% coverage
CTR3_MOUSE / P70423 Cationic amino acid transporter 3; CAT-3; CAT3; Cationic amino acid transporter y+; Solute carrier family 7 member 3 from Mus musculus (Mouse) (see paper)
TC 2.A.3.3.5 / P70423 The brain L-cationic (Arg, Lys, Orn, 2,4-diamino-n-butyrate) transporter, CAT3 (capacity of trans-stimulation by internal Arg) from Mus musculus (Mouse) (see 4 papers)
Slc7a3 / GI|123218479 Cationic amino acid transporter 3 from Mus musculus (see paper)
XP_011245815 cationic amino acid transporter 3 isoform X1 from Mus musculus
55% identity, 92% coverage
- function: Uniporter that mediates the uptake of cationic L-amino acids such as L-arginine, L-lysine and L-ornithine (PubMed:9334265). The transport is sodium ions- and pH-independent, moderately trans- stimulated and is mediated by passive diffusion (PubMed:9334265).
catalytic activity: L-arginine(in) = L-arginine(out) (RHEA:32143)
catalytic activity: L-lysine(in) = L-lysine(out) (RHEA:70935)
catalytic activity: L-ornithine(in) = L-ornithine(out) (RHEA:71199) - substrates: 2,4-diamino-n-butyrate, Argnine, Ornithine, lysine
- Identification of Sec23ip, Part of 14-3-3γ Protein Network, as a Regulator of Acute Steroidogenesis in MA-10 Leydig Cells.
Aghazadeh, Endocrinology 2020 - 2D DIGE proteomic analysis reveals fasting-induced protein remodeling through organ-specific transcription factor(s) in mice
Kamata, FEBS open bio 2018 - “...diphosphate kinase B Q01768 Nme2 Mm.1260 62 59% 7/32 17466 6.97 65 1.22 0.023 Catalase P70423 Cat Mm.4215 115 22% 12/21 60043 7.72 66 1.21 0.039 Cytoplasmic aconitate hydratase P28271 Aco1 Mm.331547 223 52% 37/77 98691 7.23 67 1.20 0.009 Peroxiredoxin1 P35700 Prdx1 Mm.30929 90 47%...”
- Extracellular arginine is required but the arginine transporter CAT3 (Slc7a3) is dispensable for mouse normal and malignant hematopoiesis.
Yan, Scientific reports 2022 - GeneRIF: Extracellular arginine is required but the arginine transporter CAT3 (Slc7a3) is dispensable for mouse normal and malignant hematopoiesis.
- p53 Promotes Cancer Cell Adaptation to Glutamine Deprivation by Upregulating Slc7a3 to Increase Arginine Uptake.
Lowman, Cell reports 2019 - GeneRIF: Slc7a3 expression is significantly induced by p53 upon glutamine deprivation.
- Genetic ablation of solute carrier family 7a3a leads to hepatic steatosis in zebrafish during fasting.
Gu, Hepatology (Baltimore, Md.) 2014 (PubMed)- GeneRIF: knockdown impaired AMPK-PPAR-alpha signaling and resulted in lipid accumulation under fasting
- Y+ and y+ L arginine transporters in neuronal cells expressing tyrosine hydroxylase.
Bae, Biochimica et biophysica acta 2005 (PubMed)- GeneRIF: In a neuronal cell model, y+,L and y+ transport systems are the predominant form of arginine uptake mechanisms and the transport of arginine is altered by membrane potential and redox factors.
Q4V799 Similar to solute carrier family 7 (Cationic amino acid transporter, y+ system), member 3 from Rattus norvegicus
51% identity, 95% coverage
XP_006257121 cationic amino acid transporter 3 isoform X1 from Rattus norvegicus
56% identity, 92% coverage
CTR3_RAT / O08812 Cationic amino acid transporter 3; CAT-3; CAT3; Cationic amino acid transporter y+; Solute carrier family 7 member 3 from Rattus norvegicus (Rat) (see paper)
56% identity, 92% coverage
- function: Uniporter that mediates the uptake of cationic L-amino acids such as L-arginine, L-lysine and L-ornithine (PubMed:9079705). The transport is sodium ions- and pH-independent, moderately trans- stimulated and is mediated by passive diffusion (PubMed:9079705).
catalytic activity: L-arginine(in) = L-arginine(out) (RHEA:32143)
catalytic activity: L-lysine(in) = L-lysine(out) (RHEA:70935)
catalytic activity: L-ornithine(in) = L-ornithine(out) (RHEA:71199)
E1B761 Cationic amino acid transporter C-terminal domain-containing protein from Bos taurus
47% identity, 96% coverage
LOC527385 LOW QUALITY PROTEIN: cationic amino acid transporter 3 from Bos taurus
49% identity, 93% coverage
- Whole-genome resequencing provides insights into the diversity and adaptation to desert environment in Xinjiang Mongolian cattle
Xu, BMC genomics 2024 - “..., DIS3L2 , SLIT2 , KCNIP4 , OSGEP , PKHD1 , LOC617141 , LOC112442378 , LOC527385 , FECH , LOC107132327 , LOC521656 , LOC530929 , LOC511936 , CLIC4 , FGF10 ), metabolic regulation and energy balance ( NCSTN , PEX19 , PDE4D , TOR1AIP2 , TOR1AIP1...”
- “...the enrichment analysis also showed three GO terms (including three genes LOC617141 , LOC112442378 , LOC527385 ) associated with transmembrane transporter activity involved in osmoregulation in the renal medulla in camel [ 17 ]. In addition, an overrepresentation of categories associated with iron ion binding was...”
- Mining the Unmapped Reads in Bovine RNA-Seq Data Reveals the Prevalence of Bovine Herpes Virus-6 in European Dairy Cows and the Associated Changes in Their Phenotype and Leucocyte Transcriptome
Buggiotti, Viruses 2020 - “...6 . These included two genes located in close proximity on bta18 ( LOC513941 and LOC527385 ) that both encode proteins involved in the transport of cationic amino acids (arginine, lysine, and ornithine). Another gene, SLC22A13 , that encodes a cation transporter involved in the transport...”
- “...Cationic amino acid transporter 3-like 0.0152 0.51 1.17 2.30 LOC112446404 Uncharacterised 0.0118 0.22 0.51 2.30 LOC527385 Cationic amino acid transporter 3-like 0.0391 0.85 1.95 2.29 NMUR2 Neuromedin U receptor 2 0.0390 0.06 0.14 2.24 ZSWIM5 Zinc finger SWIM-type containing 5 0.0249 0.118 0.26 2.23 SAMD5 Sterile...”
Q16N01 ABC-type polar-amino-acid transporter (EC 7.4.2.1) from Aedes aegypti (see paper)
XP_001662274 cationic amino acid transporter 3 from Aedes aegypti
47% identity, 90% coverage
XP_039296825 LOW QUALITY PROTEIN: high affinity cationic amino acid transporter 1 from Nilaparvata lugens
45% identity, 96% coverage
LOC109572916 cationic amino acid transporter 3-like from Bos indicus
48% identity, 92% coverage
- Copy Number Variation Discovery in South African Nguni-Sired and Bonsmara-Sired Crossbred Cattle
Kooverjee, Animals : an open access journal from MDPI 2023 - “...Genes that differed in copy number in both crossbreds included genes related to growth (SCRN2, LOC109572916) and fertility-related factors (RPS28, LOC1098562432, LOC109570037). Genes that were present only in the Bonsmara-sired crossbreds included genes relating to lipid metabolism (MAF1), olfaction (LOC109569114), body size (HES7), immunity (LOC10957335, LOC109877039)...”
- “...only in the Nguni-sired crossbreds included genes relating to ketosis (HMBOX1) and amino acid transport (LOC109572916). Results of this study indicate that Nguni and Bonsmara cattle can be utilized in crossbreeding programs as they may enhance the presence of economically important traits associated with both breeds....”
LOC510904 uncharacterized protein LOC510904 from Bos taurus
45% identity, 93% coverage
XP_039288773 high affinity cationic amino acid transporter 1 from Nilaparvata lugens
45% identity, 92% coverage
Smp_123010 putative cationic amino acid transporter from Schistosoma mansoni
55% identity, 65% coverage
- Combinatory microarray and SuperSAGE analyses identify pairing-dependently transcribed genes in Schistosoma mansoni males, including follistatin
Leutner, PLoS neglected tropical diseases 2013 - “...Smp_123300 (KC165687) S. mansoni follistatin; Smp_090140.2 - Ftz-F1 interacting protein; Smp_090520 - purin nucleoside phosphorylase; Smp_123010 cationic amino acid transporter; Smp_095360.x fatty acid binding protein; Smp_065580.x heterogeneous nuclear ribonucleoprotein k; Smp_033950 - Smad4; Smp_144390 - S. mansoni activin receptor; Smp_049760 TGFRI; Smp_093540.3 ActRI; Smp_124450 - ActRI/BMPRIa;...”
- “...in the dataset of Williams et al. [36] . Also a cationic amino acid transporter (Smp_123010) (down-regulated in EM), a fatty acid binding protein (Smp_095360.x) (down-regulated in EM), and a heterogeneous nuclear ribonucleoprotein k (Smp_065580.x) (up-regulated in EM) showed the same direction of regulation in our...”
- Gene expression patterns in larval Schistosoma mansoni associated with infection of the mammalian host
Parker-Manuel, PLoS neglected tropical diseases 2011 - “...schistosomulum transcribed a different suite of transporters. Of these, two amino acid transporters (Smp_176930, and Smp_123010, the latter cationic), distinct from that already mentioned in the tegument category, showed the greatest change (19 and 6 fold) compared to the germ ball. Their enrichment may also be...”
XP_039296817 cationic amino acid transporter 2-like isoform X1 from Nilaparvata lugens
44% identity, 91% coverage
LOC112442378 LOW QUALITY PROTEIN: cationic amino acid transporter 3-like from Bos taurus
45% identity, 93% coverage
- Whole-genome resequencing provides insights into the diversity and adaptation to desert environment in Xinjiang Mongolian cattle
Xu, BMC genomics 2024 - “...( PDE11A , DIS3L2 , SLIT2 , KCNIP4 , OSGEP , PKHD1 , LOC617141 , LOC112442378 , LOC527385 , FECH , LOC107132327 , LOC521656 , LOC530929 , LOC511936 , CLIC4 , FGF10 ), metabolic regulation and energy balance ( NCSTN , PEX19 , PDE4D , TOR1AIP2...”
- “...]. Moreover, the enrichment analysis also showed three GO terms (including three genes LOC617141 , LOC112442378 , LOC527385 ) associated with transmembrane transporter activity involved in osmoregulation in the renal medulla in camel [ 17 ]. In addition, an overrepresentation of categories associated with iron ion...”
LOC100168178 uncharacterized protein LOC100168178 from Acyrthosiphon pisum
42% identity, 93% coverage
- Whitefly genome expression reveals host-symbiont interaction in amino acid biosynthesis
Upadhyay, PloS one 2015 - “...48 ACYPI000550 (LOC100159152) Unitig_68785 253 Unitig_21655 57 Unitig_40249 36 ACYPI001018(LOC100159667) Unitig_47082 172 Unitig_49482 126 ACYPI008904 (LOC100168178) Unitig_52040 95 Unitig_52329 98 ACYPI008971 (LOC100168251) Unitig_36271 78 Conclusions Comprehensive analysis of the transcriptome data of the whitefly has provided important information regarding the mechanism of cooperation between the host...”
- Aphid amino acid transporter regulates glutamine supply to intracellular bacterial symbionts
Price, Proceedings of the National Academy of Sciences of the United States of America 2014 - “...ACYPI000550 (LOC100159152), ACYPI001018 (LOC100159667), ACYPI008904 (LOC100168178), Price et al. and ACYPI008971 (LOC100168251)--are expressed in bacteriocytes...”
- “...ACYPI000550 (LOC100159152), ACYPI001018 (LOC100159667), ACYPI008904 (LOC100168178), and ACYPI008971 (LOC100168251) were amplified from A. pisum bacteriocyte...”
S7A14_HUMAN / Q8TBB6 Solute carrier family 7 member 14; Gamma-aminobutyric acid transporter SLC7A14 from Homo sapiens (Human) (see 2 papers)
NP_066000 solute carrier family 7 member 14 from Homo sapiens
40% identity, 78% coverage
- function: Imports 4-aminobutanoate (GABA) into lysosomes. May act as a GABA sensor that regulates mTORC2-dependent INS signaling and gluconeogenesis. The transport mechanism and substrate selectivity remain to be elucidated.
catalytic activity: 4-aminobutanoate(in) = 4-aminobutanoate(out) (RHEA:35035) - Proteomics-based insights into mitogen-activated protein kinase inhibitor resistance of cerebral melanoma metastases
Zila, Clinical proteomics 2018 - “...Q6PML9 Zinc transporter 9 SLC30A9 1.57 1.36E02 Q8N4V1 Membrane magnesium transporter 1 MMGT1 1.19 3.22E02 Q8TBB6 Probable cationic amino acid transporter SLC7A14 1.78 6.86E03 Q96QE2 Proton myo-inositol cotransporter SLC2A13 2.68 1.94E06 * Q99726 Zinc transporter 3 SLC30A3 2.03 2.95E02 Q9H1V8 Sodium-dependent neutral amino acid transporter SLC6A17...”
- The Concise Guide to PHARMACOLOGY 2013/14: transporters
Alexander, British journal of pharmacology 2013 - “...CAT1 CAT2 CAT3 CAT4 HGNC, UniProt SLC7A1, P30825 SLC7A2, P52569 SLC7A3, Q8WY07 SLC7A4, O43246 SLC7A14, Q8TBB6 Substrates L-arginine, L-lysine, L-ornithine, L-histidine L-arginine, L-lysine, L-ornithine, L-histidine L-arginine, L-lysine, L-ornithine Glycoprotein-associated amino acid transporters are 12 TM proteins, which heterodimerize with members of the SLC3 family to act...”
- Mutation of SLC7A14 causes auditory neuropathy and retinitis pigmentosa mediated by lysosomal dysfunction.
Giffen, Science advances 2022 - GeneRIF: Mutation of SLC7A14 causes auditory neuropathy and retinitis pigmentosa mediated by lysosomal dysfunction.
- Phenotypic variability of SLC7A14 mutations in patients with inherited retinal dystrophy.
Guo, Ophthalmic genetics 2019 (PubMed)- GeneRIF: We applied Targeted exome sequencing to the molecular diagnosis of patients with inherited retinal dystrophy and for the first time identified SLC7A14 mutations in two unrelated families with retinitis pigmentosa and Leber congenital amaurosis separately.
- SLC7A14 linked to autosomal recessive retinitis pigmentosa.
Jin, Nature communications 2014 - GeneRIF: Data suggests that cationic transporter SLC7A14 has an important role in retinal development and visual function.
- A chimera carrying the functional domain of the orphan protein SLC7A14 in the backbone of SLC7A2 mediates trans-stimulated arginine transport.
Jaenecke, The Journal of biological chemistry 2012 - GeneRIF: A chimera carrying the functional domain of the orphan protein SLC7A14 in the backbone of SLC7A2 mediates trans-stimulated arginine transport.
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose, Molecular medicine (Cambridge, Mass.) - GeneRIF: Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
- Screening for SLC7A14 gene mutations in patients with autosomal recessive or sporadic retinitis pigmentosa.
Sugahara, Ophthalmic genetics (PubMed)- GeneRIF: The four SLC7A14 mutations detected herein were unlikely to be pathogenic in this Japanese cohort. The frequency and pathogenicity of SLC7A14 mutations may vary depending on ethnicity, and these mutations may be rare in Japanese patients.
W5NQG5 Cationic amino acid transporter C-terminal domain-containing protein from Ovis aries
41% identity, 95% coverage
XP_039296923 cationic amino acid transporter 4 from Nilaparvata lugens
42% identity, 90% coverage
S7A14_MOUSE / Q8BXR1 Solute carrier family 7 member 14; Gamma-aminobutyric acid transporter SLC7A14 from Mus musculus (Mouse) (see 2 papers)
NP_766449 solute carrier family 7 member 14 from Mus musculus
40% identity, 79% coverage
- function: Imports 4-aminobutanoate (GABA) into lysosomes. May act as a GABA sensor that regulates mTORC2-dependent INS signaling and gluconeogenesis. The transport mechanism and substrate selectivity remain to be elucidated.
catalytic activity: 4-aminobutanoate(in) = 4-aminobutanoate(out) (RHEA:35035)
disruption phenotype: Mutant mice exhibit slightly thinner retina, including outer retinal layer, and abnormal electroretinography at 2 and 6 months of age compared to wild-type animals. They are viable and fertile. They do not show any noticeable physical abnormalities. - Onecut Regulates Core Components of the Molecular Machinery for Neurotransmission in Photoreceptor Differentiation.
Vassalli, Frontiers in cell and developmental biology 2021 - “...Complexin-2 (Cplx2) 1.19 1.00 P84087 Complexin-2 ENS_19724 Probable cationic amino acid transporter (Slc7a14) 1.05 1.10 Q8BXR1 Probable cationic amino acid transporter ENS_03816 NA 1.04 0.99 F6ZT94 Uncharacterized protein ENS_23426 NA 1.16 1.42 H2XJT7 Uncharacterized protein ENS_21806 Sodium-dependent serotonin transporter-like (Slc6) 1.48 2.08 H2XWG9 Uncharacterized protein ENS_23151...”
- Mapping protein interactions of sodium channel NaV1.7 using epitope-tagged gene-targeted mice
Kanellopoulos, The EMBO journal 2018 - “...sodium bicarbonate exchanger 1 Q8JZR62 1.82E08 0.00E+00 KI only Slc7a14 Probable cationic amino acid transporter Q8BXR1 1.07E08 0.00E+00 KI only Sgk223 Tyrosineprotein kinase SgK223 Q571I4 7.46E09 0.00E+00 KI only Other selected candidates for validation Slc7a5/Lat1 Large neutral amino acids transporter small subunit 1 Q9Z127 1.66E07 3.11E08...”
- Apolipoprotein E mimetic peptide, CN-105, improves outcomes in ischemic stroke.
Tu, Annals of clinical and translational neurology 2017 - “...P09411 LGDV Y VNDAFGTAHR (161) 3.703 0.011 Glycolysis Unknown Probable cationic amino acid transporter Slc7a14, Q8BXR1 EQALHQST Y QR (693) 2.369 0.040 Amino acid transporter, Anion transport Unknown Probable Gproteincoupled receptor 158 Gpr158, Q8C419 KL Y AQLEIYKR (722) 2.507 0.003 Gproteincoupled receptor signaling Novel phosphorylation site...”
- Hypothalamic SLC7A14 accounts for aging-reduced lipolysis in white adipose tissue of male mice.
Jiang, Nature communications 2024 - GeneRIF: Hypothalamic SLC7A14 accounts for aging-reduced lipolysis in white adipose tissue of male mice.
- SLC7A14 imports GABA to lysosomes and impairs hepatic insulin sensitivity via inhibiting mTORC2.
Jiang, Cell reports 2023 (PubMed)- GeneRIF: SLC7A14 imports GABA to lysosomes and impairs hepatic insulin sensitivity via inhibiting mTORC2.
- Mutation of SLC7A14 causes auditory neuropathy and retinitis pigmentosa mediated by lysosomal dysfunction.
Giffen, Science advances 2022 - GeneRIF: Mutation of SLC7A14 causes auditory neuropathy and retinitis pigmentosa mediated by lysosomal dysfunction.
CG13248 uncharacterized protein from Drosophila melanogaster
40% identity, 89% coverage
- Animal amino acid sensor - A review
Ke, Animal bioscience 2025 - “...signaling process of DH44 neurons stimulated by L-Glu, L-Ala and L-Asp through the channel proteins CG13248 and CG4991. When the amino acid enters the cell, it inhibits the expression of GCN2, and then transmits the signal to DH44 neurons, and finally to DH44-R1/R2. L-Glu, L-glutamic; L-Ala,...”
- Differential amino acid transporter expression in adult Drosophila melanogaster tissues
Wright, microPublication biology 2024 - “...carcass, which houses the fat body and hemocytes, major mediators of the Drosophila immune response. CG13248 is expressed in all tissues examined but the ovary ( Fig. 1V ). CG13248 transports histidine in fly photoreceptors (Han et al., 2022) and is also highly expressed in neurons...”
- “...CG1607, CD98hc, mnd, dmGlut, sbm, CG12773, Ctns, CG8026, Eaat1, CG4995, aralar1, CG13384, Ncc69, polyph, and CG13248 ). The ovary expresses all but three AAT transcripts, with 10 showing moderate to high expression levels ( CD98hc, dmGlut, sbm, CG12773, CG32079, CG8026, Cg7255, CG4995, Cg13384, and Ncc69 )....”
- Synaptic connectome of a neurosecretory network in theDrosophilabrain
McKim, 2024 - Tadr is an axonal histidine transporter required for visual neurotransmission in Drosophila
Han, eLife 2022 - “...A2 CG30394 Yes Amino acid transmembrane transporter activity/SLC38A10 CG13743 Yes Amino acid transmembrane transporter activity/SLC38A11 CG13248 Yes Amino acid transmembrane transporter activity/SLC7A4 slif Yes Amino acid transmembrane transporter activity/SLC7A1 or A2 CG12773 Yes Amino acid transmembrane transporter activity/SLC12A8 NKCC Yes Amino acid transmembrane transporter activity/SLC12A3 ChT...”
- “...CG13248-transfected cells, but not by Slif (Slimfast)-positive cells ( Figure 6A ). Next, we overexpressed CG13248 or Slif in tadr 2 mutant photoreceptor cells. The expression of CG13248 in tadr 2 mutant photoreceptor cells fully restored both ERG transients and phototaxis, whereas Slif did not. These...”
- Methionine restriction breaks obligatory coupling of cell proliferation and death by an oncogene Src in Drosophila
Nishida, eLife 2021 - “...Flybase FLYB: FBgn0005278 NA Gene Drosophila melanogaster samtor Flybase FLYB: FBgn0035035 NA Gene Drosophila melanogaster CG13248 Flybase FLYB: FBgn0036984 NA Gene Drosophila melanogaster tadr Flybase FLYB: FBgn0036984 NA Gene Drosophila melanogaster CG9413 Flybase FLYB: FBgn0030574 NA Gene Drosophila melanogaster jhl-21 Flybase FLYB: FBgn0028425 NA Gene Drosophila...”
- “...and Miura, 2015 PMID: 32938923 F: 5'- GCCAACGGCGTTCATATC -3' R: 5'- GGCATATCCAAACATGATACCC -3' Sequence-based reagent CG13248 (primer) FlyPrimerBank PP18106 F: 5'- AAACCGATGCCTCAACACCTT -3' R: 5'- CAGTCAGCACGTAGATGCCA -3' Sequence-based reagent tadr (primer) FlyPrimerBank PP20579 F: 5'- CAGCCCGCTGTAAAACTAGC -3' R: 5'- GGCCAGAGCATCTAGCCAG -3' Sequence-based reagent CG9413 (primer) FlyPrimerBank...”
- Growth regulation by amino acid transporters in Drosophila larvae
Manière, Cellular and molecular life sciences : CMLS 2020 - “...directly stimulate DH44+brain neurons to increase in food consumption via a putative amino acid transporter, CG13248 [ 53 , 54 ]. In adult females, nutrients play also an important role in germline stem cells development. This requires specific nutrient-responsive signaling pathways which includes insulin/IGF signaling, TOR...”
- Recent advances in the neural regulation of feeding behavior in adult Drosophila
Wang, Journal of Zhejiang University. Science. B 2019 - “...a manner that requires putative amino acid transporters (CG13248 and CG4991). Essential amino acid-deficient (EAAD) food rejection is mediated by a group of...”
- A post-ingestive amino acid sensor promotes food consumption in Drosophila
Yang, Cell research 2018 - “...promote food consumption. Single-cell transcriptome analysis and immunostaining reveal that a putative amino acid transporter, CG13248, is enriched in DH44 + neurons. Knocking down CG13248 expression in DH44 + neurons blocks the increase in food consumption and eliminates calcium responses induced by dietary amino acids. Therefore,...”
- “...key sensor to detect amino acids and to enhance food intake via a putative transporter CG13248. These results shed critical light on the regulation of protein homeostasis at organismal levels by the nervous system. issue-copyright-statement IBCB, SIBS, CAS 2018 Introduction Proteins are the most abundant macromolecules...”
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Q60458 Cationic amino acid transporter-1 (Fragment) from Cricetulus griseus
67% identity, 50% coverage
LOC615600 cationic amino acid transporter 3-like from Bos taurus
43% identity, 92% coverage
- Breed of origin analysis in genome-wide association studies: enhancing SNP-based insights into production traits in a commercial Brangus population
Zayas, BMC genomics 2024 - “...- MARB 5 40,358,402 40,368,402 MUC19/BSM1, LRRK2 - 4.51% - - MARB 18 60,965,880 60,975,880 LOC615600, NLRP12 1.48% 2.13% - - MARB 18 55,496,930 55,506,930 NUCB1 2.77% 1.00% - - MARB 27 1,355,462 1,365,462 ARHGEF10 - - 1.09% - MARB 28 5,870,881 5,880,881 NTPCR, PCNX2 1.52%...”
NP_004164 cationic amino acid transporter 4 from Homo sapiens
O43246 Cationic amino acid transporter 4 from Homo sapiens
41% identity, 91% coverage
- Association of serotonin and dopamine gene pathways with behavioral subphenotypes in dementia.
Proitsi, Neurobiology of aging 2012 (PubMed)- GeneRIF: Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
- Influence of serotonin transporter gene polymorphisms on clozapine response in Brazilian schizophrenics.
Kohlrausch, Journal of psychiatric research 2010 (PubMed)- GeneRIF: Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
- The role of clinical variables, neuropsychological performance and SLC6A4 and COMT gene polymorphisms on the prediction of early response to fluoxetine in major depressive disorder.
Gudayol-Ferré, Journal of affective disorders 2010 (PubMed)- GeneRIF: Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
- Characterization of de novo diffuse large B-cell lymphoma with a translocation of c-myc and immunoglobulin genes.
Kikuchi, Leukemia research 2008 (PubMed)- GeneRIF: These results suggest a heterogeneous immunophenotype and genotype for c-myc/Ig DLBCL, with CD10(-)/BCL6(+)/MUM1(-) cases the most frequent.
- Comparative analysis of ZAP-70 expression and Ig VH mutational status in B-cell chronic lymphocytic leukemia.
Muñoz, Cytometry. Part B, Clinical cytometry 2007 (PubMed)- GeneRIF: ZAP-70 reactivity using a T-cell marker as a control allows to identify the majority of patients with an unmutated Ig VH genotype.
- Expression of solute carrier 7A4 (SLC7A4) in the plasma membrane is not sufficient to mediate amino acid transport activity.
Wolf, The Biochemical journal 2002 - GeneRIF: expression in cell membrane is not sufficient for amino acid transport (SOLUTE CARRIER SLC7A4)
- Analysis of the genomic organization of the human cationic amino acid transporters CAT-1, CAT-2 and CAT-4.
Hammermann, Amino acids 2001 (PubMed)- GeneRIF: analysis of the genomic organization
- Predicting Drug-Target Interactions Based on the Ensemble Models of Multiple Feature Pairs
Wang, International journal of molecular sciences 2021 - “...In addition, two predicted drugtarget pairs were demonstrated as interactions (Lysine (DB00194) interacts with SLC7A4 (O43246) [ 40 , 41 ], and Micafungin (DB01141) interacts with FKSA (A2QLK4)) [ 42 , 43 ]. 5. Conclusions In this work, an algorithm based on the Ensemble models of...”
- The Concise Guide to PHARMACOLOGY 2013/14: transporters
Alexander, British journal of pharmacology 2013 - “...Common abbreviation CAT1 CAT2 CAT3 CAT4 HGNC, UniProt SLC7A1, P30825 SLC7A2, P52569 SLC7A3, Q8WY07 SLC7A4, O43246 SLC7A14, Q8TBB6 Substrates L-arginine, L-lysine, L-ornithine, L-histidine L-arginine, L-lysine, L-ornithine, L-histidine L-arginine, L-lysine, L-ornithine Glycoprotein-associated amino acid transporters are 12 TM proteins, which heterodimerize with members of the SLC3 family...”
XP_039296913 LOW QUALITY PROTEIN: cationic amino acid transporter 3 from Nilaparvata lugens
50% identity, 66% coverage
LOC513941 cationic amino acid transporter 3 from Bos taurus
42% identity, 92% coverage
- Genome Wide Association Study of Beef Traits in Local Alpine Breed Reveals the Diversity of the Pathways Involved and the Role of Time Stratification
Mancin, Frontiers in genetics 2021 - “...significant SNPs some were mapped within genes, such as SLC12A1 , CGNL1 , PRTG (ADG), LOC513941 (CF), NLRP2 (CF and DP), CDC155 (DP). Pathway analysis showed great diversity in the biological pathways linked to the different traits; several were associated with neurogenesis and synaptic transmission, but...”
- “...148,893,434 8.77E-06 SIM2 80.004 DP 18 58,645,859 1.06E-05 LOC101904435 within CF DP 18 61,137,684 1.15E-05 LOC513941 within CF DP 4 99,574,406 2.34E-05 LOC112446424 within DP 18 57,735,853 3.03E-05 LOC787554 within CF DP 18 62,427,814 4.49E-05 NLRP2 within DP 18 63,362,491 4.97E-05 LOC107131476 560 DP 17 72055006...”
- Mining the Unmapped Reads in Bovine RNA-Seq Data Reveals the Prevalence of Bovine Herpes Virus-6 in European Dairy Cows and the Associated Changes in Their Phenotype and Leucocyte Transcriptome
Buggiotti, Viruses 2020 - “...in Table 6 . These included two genes located in close proximity on bta18 ( LOC513941 and LOC527385 ) that both encode proteins involved in the transport of cationic amino acids (arginine, lysine, and ornithine). Another gene, SLC22A13 , that encodes a cation transporter involved in...”
- “...0.55 1.33 2.39 ATF7IP2 Activating transcription factor 7 interacting protein 2 0.0457 0.07 0.17 2.36 LOC513941 Cationic amino acid transporter 3-like 0.0152 0.51 1.17 2.30 LOC112446404 Uncharacterised 0.0118 0.22 0.51 2.30 LOC527385 Cationic amino acid transporter 3-like 0.0391 0.85 1.95 2.29 NMUR2 Neuromedin U receptor 2...”
LOC789418 cationic amino acid transporter 3 from Bos taurus
49% identity, 68% coverage
S7A14_DANRE / B0UYF2 Probable cationic amino acid transporter; Solute carrier family 7 member 14 from Danio rerio (Zebrafish) (Brachydanio rerio) (see paper)
49% identity, 52% coverage
- function: May be involved in arginine transport.
disruption phenotype: Morpholino knockdown of the protein causes smaller eyes compared to wild-type animals and aberrant light-induced locomotor response.
CAAT2_ARATH / Q9ASS7 Cationic amino acid transporter 2, vacuolar from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
TC 2.A.3.3.13 / Q9ASS7 Cationic amino acid transporter 2, vacuolar from Arabidopsis thaliana (see 4 papers)
AT1G58030 CAT2 (CATIONIC AMINO ACID TRANSPORTER 2); amino acid transmembrane transporter from Arabidopsis thaliana
37% identity, 91% coverage
- function: Permease involved in the transport of the cationic amino acids.
- substrates: Amino acids
- Nucleotide Imbalance, Provoked by Downregulation of Aspartate Transcarbamoylase Impairs Cold Acclimation in Arabidopsis
Bellin, Molecules (Basel, Switzerland) 2023 - “...2.01 1.58 0.70 0.72 PL nucleotide AT1G61800 GPT2 5.90 7.61 0.39 1.65 PL Glc6P, TP AT1G58030 CAT2 1.40 1.32 0.62 TP amino acid AT5G40890 CLCa 2.34 1.50 0.56 TP Cl, nitrate AT3G16240 TIP2.1 3.42 3.74 0.48 0.97 TP H 2 O AT3G26520 TIP1.2 2.08 1.85 0.49...”
- Involvement of JMJ15 in the dynamic change of genome-wide H3K4me3 in response to salt stress
Shen, Frontiers in plant science 2022 - “...inhibited during the salt treatment. Similarly, we found some stress related genes such as CAT2 (AT1G58030), XTH6 (AT5G65730), XTH22 / TCH4 (AT5G57560), HSFA2 (AT2G26150), NRT2.6 (AT3G45060), HSP70-2 (AT5G02490), COR15A (AT2G42540), COR15B (AT2G42530), NAC13 (AT1G32870), VSP2 (AT5G24770) that were upregulated in Col-0 under salt/normal but downregulated in...”
- Cellular export of sugars and amino acids: role in feeding other cells and organisms
Kim, Plant physiology 2021 - “...protein PUT1 (At1g31820), AAP1 (At1g58360), cationic amino acid transporters CAT4 (At3g03720), CAT9 (At1g05940), and CAT2 (At1g58030) is indicated. The logit score for UmamiT45 was 14.2. Figure 4 The role of SWEETs and UmamiTs in Arabidopsis, rice, and maize. A, The role of SWEETs and UmamiTs during...”
- Transcription factor CDF4 promotes leaf senescence and floral organ abscission by regulating abscisic acid and reactive oxygen species pathways in Arabidopsis
Xu, EMBO reports 2020 (secret) - Transcription of putative tonoplast transporters in response to glyphosate and paraquat stress in Conyza bonariensis and Conyza canadensis and selection of reference genes for qRT-PCR
Moretti, PloS one 2017 - “...of a cationic amino acid transporter (CAT), [ 22 ]. In Arabidopsis , both CAT2 (AT1G58030) and CAT4 (AT3G03720) encode CATs which are primarily localized to the tonoplast [ 23 ], making them appropriate candidates for the vacuolar sequestration of paraquat. In glyphosate-paraquat-resistant (GPR) Conyza spp...”
- “...4e -105 CATIONIC AMINO ACID TRANSPORTER 4 (CAT4) NM_111243.7 AT3G03720 JSWR01002601.1 77 2e -37 NM_179491.2 AT1G58030 83 5-ENOL-PYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE (EPSPS) NM_130093.2 AT2G45300 AY545666; JSWR01004464.1 78 7e -41 AY545667; JSWR01002887.1 77 3e -39 AY545668; JSWR01015937.1 71 2e -23 a Gene nomenclature followed Arabidopsis thaliana genes. b Arabidopsis...”
- Metabolomics as a Hypothesis-Generating Functional Genomics Tool for the Annotation of Arabidopsis thaliana Genes of "Unknown Function"
Quanbeck, Frontiers in plant science 2012 - “...(the minimum number of detected metabolic changes was 4 metabolites, associated with the mutation in At1g58030), 55 mutant alleles show between 10 and 30 metabolic changes, and 9 mutant alleles showed more than 30 altered metabolite abundances; the highest number of detected altered metabolites being 46....”
- DNA methylation in an intron of the IBM1 histone demethylase gene stabilizes chromatin modification patterns
Rigal, The EMBO journal 2012 - “...genes for H3K9me2 demethylation, all genes but one (AT1G58030) showed ectopic CHG methylation in the ibm1 mutant background compared with the WT. Among these,...”
- Transcriptome analysis reveals absence of unintended effects in drought-tolerant transgenic plants overexpressing the transcription factor ABF3
Abdeen, BMC genomics 2010 - “...transporter family protein 1.017 1.540 1.826 263918_at At2g36590 Proline transporter 3 (ProT3) 1.907 1.845 245868_at At1g58030 Cationic amino acid transporter 2 (CAT2) -1.406 260543_at At2g43330 Inositol transporter 1 (AtINT1) 1.118 0.160 262756_at At1g16370 Organic cation/carnitine transporter 6 (AtOCT6)/carbohydrate transmembrane transporte 1.992 245499_at At4g16480 Inositol transporter 4...”
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Smp_004190 putative cationic amino acid transporter from Schistosoma mansoni
38% identity, 91% coverage
- Gene Atlasing of digestive and reproductive tissues in Schistosoma mansoni
Nawaratna, PLoS neglected tropical diseases 2011 - “...fasting-inducible integral membrane protein tm6p1-related Q2_P23552 Smp_152050 3.08 C807737.1 tetraspanin 18, isoform 1, putative Q2_P30192 Smp_004190 2.76 C904653.1 cationic amino acid transporter, putative Q2_P19424 Smp_138380 2.57 C802143.1 leucine aminopeptidase- related Q2_P19417 Smp_139160 2.33 C802136.1 cysteine protease family C1-related Q2_P03089 Smp_162770 2.7 C806088.1 lysosome-associated membrane glycoprotein Q2_P03953...”
LOC11435913 cationic amino acid transporter 4, vacuolar from Medicago truncatula
36% identity, 90% coverage
- Genome-wide association analysis for drought tolerance and associated traits in faba bean (Vicia faba L.)
Gutiérrez, Frontiers in plant science 2023 - “...2.3 VF1L LOC11430458 - MTR_5g083560 Cation/H(+) antiporter 14 Chr5: 37,260,367 - 37,261,590 AX-181483294 1.9 VF5 LOC11435913 - MTR_7g086510 Cationic amino acid transporter 4, vacuolar Chr7: 40,354,298 - 40,361,570 AX-416771643 0.9 VF1L LOC11426550 - MTR_5g082490 Protein yippee-like Chr5: 36,649,198 - 36,652,967 AX-416761080 0.8 VF6 LOC25492837 - MTR_4g074390...”
XP_039279370 probable cationic amino acid transporter from Nilaparvata lugens
48% identity, 53% coverage
NP_001265934 cationic amino acid transporter 2, vacuolar-like from Solanum lycopersicum
36% identity, 90% coverage
AT3G03720 CAT4 (CATIONIC AMINO ACID TRANSPORTER 4); cationic amino acid transmembrane transporter from Arabidopsis thaliana
34% identity, 74% coverage
- Cellular export of sugars and amino acids: role in feeding other cells and organisms
Kim, Plant physiology 2021 - “...-coexpressed UmamiTs , AAP family protein PUT1 (At1g31820), AAP1 (At1g58360), cationic amino acid transporters CAT4 (At3g03720), CAT9 (At1g05940), and CAT2 (At1g58030) is indicated. The logit score for UmamiT45 was 14.2. Figure 4 The role of SWEETs and UmamiTs in Arabidopsis, rice, and maize. A, The role...”
- Transcription of putative tonoplast transporters in response to glyphosate and paraquat stress in Conyza bonariensis and Conyza canadensis and selection of reference genes for qRT-PCR
Moretti, PloS one 2017 - “...amino acid transporter (CAT), [ 22 ]. In Arabidopsis , both CAT2 (AT1G58030) and CAT4 (AT3G03720) encode CATs which are primarily localized to the tonoplast [ 23 ], making them appropriate candidates for the vacuolar sequestration of paraquat. In glyphosate-paraquat-resistant (GPR) Conyza spp ., reduced translocation...”
- “...MRP8 (M11) NM_112148.3 AT3G13090 JSWR01014711.1 67 4e -105 CATIONIC AMINO ACID TRANSPORTER 4 (CAT4) NM_111243.7 AT3G03720 JSWR01002601.1 77 2e -37 NM_179491.2 AT1G58030 83 5-ENOL-PYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE (EPSPS) NM_130093.2 AT2G45300 AY545666; JSWR01004464.1 78 7e -41 AY545667; JSWR01002887.1 77 3e -39 AY545668; JSWR01015937.1 71 2e -23 a Gene nomenclature...”
- Transcriptome-wide high-throughput deep m(6)A-seq reveals unique differential m(6)A methylation patterns between three organs in Arabidopsis thaliana
Wan, Genome biology 2015 - “...AT5G53530, AT5G01990, AT3G55320, AT4G13750, AT1G16820, AT1G77140, AT5G05570, AT5G07770, AT2G21340, AT2G27460, AT1G74720, AT1G47550, AT5G66380, AT5G47490, AT5G08470, AT3G03720, AT5G61310, AT5G62600, AT5G11980, AT1G56290, AT2G20840, AT2G15240, AT4G39420, AT5G07980, [ 15 21 ] Defense or stress response AT1G63770, AT1G64790, AT1G67090, AT1G80030, AT2G05580, AT2G27380, AT2G35510, AT2G42560, AT3G20290, AT3G22640, AT3G49600, AT4G01210, AT4G04920, AT4G08230,...”
- The AAP gene family for amino acid permeases contributes to development of the cyst nematode Heterodera schachtii in roots of Arabidopsis
Elashry, Plant physiology and biochemistry : PPB 2013 - “...0.2 0.43 At1g58032 AtCAT2 not available on GeneChip At5g36940 AtCAT3 7.8 6 1.8 a 0.00 At3g03720 AtCAT4 6.7 5.4 1.3 0.03 At2g34960 AtCAT5 3.5 3.1 0.4 0.24 At5g04770 AtCAT6 5.3 5.9 0.6 0.03 At3g10600 AtCAT7 3.3 3 0.3 0.20 At1g17120 AtCAT8 6.5 5.6 0.9 a 0.00...”
- A proteomics dissection of Arabidopsis thaliana vacuoles isolated from cell culture
Jaquinod, Molecular & cellular proteomics : MCP 2007 - “...2d Transp. NF NF At5g40670 At1g05940 At1g58030 At3g03720 At1g17120 At3g30390 At2g41190 At2g39130 At2g40420 At3g28960 At1g70330 31,007 60,138 67,072 63,597...”
CAAT4_ARATH / Q8W4K3 Cationic amino acid transporter 4, vacuolar from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
TC 2.A.3.3.14 / Q8W4K3 Cationic amino acid transporter 4, vacuolar from Arabidopsis thaliana (see 4 papers)
NP_001154586 cationic amino acid transporter 4 from Arabidopsis thaliana
34% identity, 91% coverage
DDB_G0279983, XP_641447 solute carrier family 7 member protein from Dictyostelium discoideum AX4
34% identity, 80% coverage
- GNP2 Encodes a High-Specificity Proline Permease in Candida albicans
Garbe, mBio 2022 - “...pair group method using average linkages [UPGMA], and default settings). The Dictyostelium discoideum hypothetical protein DDB_G0279983 (GenBank accession number XP_641447 ) was used as the outgroup. S. cerevisiae AAPs are indicated in blue, and C. albicans AAPs are in red. 10.1128/mBio.03142-21.8 TABLES1 Putative proline permeases in...”
- “...average linkages [UPGMA], and default settings). The Dictyostelium discoideum hypothetical protein DDB_G0279983 (GenBank accession number XP_641447 ) was used as the outgroup. S. cerevisiae AAPs are indicated in blue, and C. albicans AAPs are in red. 10.1128/mBio.03142-21.8 TABLES1 Putative proline permeases in C. albicans . Download...”
CAAT3_ARATH / Q8GYB4 Cationic amino acid transporter 3, mitochondrial from Arabidopsis thaliana (Mouse-ear cress) (see paper)
AT5G36940 CAT3 (CATIONIC AMINO ACID TRANSPORTER 3); basic amino acid transmembrane transporter/ cationic amino acid transmembrane transporter from Arabidopsis thaliana
35% identity, 90% coverage
- function: Permease involved in the transport of the cationic neutral or acidic amino acids.
- DEG10 contributes to mitochondrial proteostasis, root growth, and seed yield in Arabidopsis
Huber, Journal of experimental botany 2019 - “...bp between intron 9 of the Cationic Amino Acid Transporter 3 gene ( CATR3 ; At5g36940, previously referred to as CAT3 , although this is commonly used for Catalase 3 ) and exon 8 of DEG10 ( Fig. 4A ). Since we did not find any...”
- Overexpression of a tomato miR171 target gene SlGRAS24 impacts multiple agronomical traits via regulating gibberellin and auxin homeostasis
Huang, Plant biotechnology journal 2017 - “...1 allergen and extensin 1.16 1.23 Solyc12g014580.1 Pollen allergen Ole e 6 1.14 1.29 Solyc10g081460.1 AT5G36940 CAT3, involved in amino acid transport 1.1 1.06 Solyc09g010090.2 AT3G52600 Cell wall invertase 2, involved in sucrose catabolic process 1.33 1.23 Solyc01g107830.2 AT3G53160.1 UDPglycosyltransferase superfamily protein 2.66 3.4 Hormone signallingrelated...”
- Transcriptome-wide high-throughput deep m(6)A-seq reveals unique differential m(6)A methylation patterns between three organs in Arabidopsis thaliana
Wan, Genome biology 2015 - “...AT2G07687, AT2G07698, AT2G07741, AT2G41700, AT3G08650, AT3G08960, AT3G17430, AT3G20560, AT3G20920, AT3G46830, AT4G00630, AT4G00800, AT4G38920, AT4G39850, AT5G27970, AT5G36940, AT5G53530, AT5G01990, AT3G55320, AT4G13750, AT1G16820, AT1G77140, AT5G05570, AT5G07770, AT2G21340, AT2G27460, AT1G74720, AT1G47550, AT5G66380, AT5G47490, AT5G08470, AT3G03720, AT5G61310, AT5G62600, AT5G11980, AT1G56290, AT2G20840, AT2G15240, AT4G39420, AT5G07980, [ 15 21 ] Defense or...”
- The AAP gene family for amino acid permeases contributes to development of the cyst nematode Heterodera schachtii in roots of Arabidopsis
Elashry, Plant physiology and biochemistry : PPB 2013 - “...4.6 0.6 0.13 At4g21120 AtCAT1 4.4 4.6 0.2 0.43 At1g58032 AtCAT2 not available on GeneChip At5g36940 AtCAT3 7.8 6 1.8 a 0.00 At3g03720 AtCAT4 6.7 5.4 1.3 0.03 At2g34960 AtCAT5 3.5 3.1 0.4 0.24 At5g04770 AtCAT6 5.3 5.9 0.6 0.03 At3g10600 AtCAT7 3.3 3 0.3 0.20...”
Smp_176940 putative cationic amino acid transporter from Schistosoma mansoni
31% identity, 90% coverage
- Stem cell progeny contribute to the schistosome host-parasite interface
Collins, eLife 2016 - “...of known tegumental factors, including sm13 (Smp_195190), sm29 (Smp_072190), sm25 (Smp_195180), an amino acid transporter (Smp_176940) ( Wilson, 2012 ), a dysferlin protein (Smp_141010) ( Braschi and Wilson, 2006 ; Wilson, 2012 ), an endophillin B1 ( Castro-Borges et al., 2011 ; Wilson, 2012 ), and...”
- Gene expression patterns in larval Schistosoma mansoni associated with infection of the mammalian host
Parker-Manuel, PLoS neglected tropical diseases 2011 - “...identity, 65% conserved amino acids with the known amino acid transporter of the adult tegument (Smp_176940), the two genes being adjacent on a chromosome. This may indicate a degree of stage-specificity in amino acid uptake. Also enriched in the day 3 schistosomulum were a second monocarboxylate...”
GBAA_0818 amino acid permease from Bacillus anthracis str. 'Ames Ancestor'
BAS0779 amino acid permease family protein from Bacillus anthracis str. Sterne
40% identity, 64% coverage
- BrnQ-Type Branched-Chain Amino Acid Transporters Influence Bacillus anthracis Growth and Virulence
Dutta, mBio 2022 - “...GBAA_1935, and GBAA_1936, predicted to be ABC transporters for BCAAs as well as another gene, GBAA_0818, that is similar to bcaP , an amino acid permease gene that is found in many Gram-positive bacteria ( 16 , 29 , 31 , 49 ). In contrast, the...”
- Identification of CodY targets in Bacillus anthracis by genome-wide in vitro binding analysis
Château, Journal of bacteriology 2013 - “...(nprB) BAS0580 BAS0610 BAS0638 (inhA2) BAS0660 BAS0669 BAS0779 BAS0809 BAS0841 (sap) BAS0842 (eag) BAS0842 (eag) BAS0847 BAS0848* IMP dehydrogenase Transition...”
BMB171_C0217 amino acid permease from Bacillus thuringiensis BMB171
40% identity, 62% coverage
- Single Amino Acid Substitution in Homogentisate Dioxygenase Affects Melanin Production in Bacillus thuringiensis
Yang, Frontiers in microbiology 2018 - “...HAD superfamily hydrolase; BMB171_C0214, HppD, 4-hydroxyphenylpyruvate dioxygenase; BMB171_C0215, FahA, fumarylacetoacetate hydrolase; BMB171_C0216, HmgA, homogentisate 1,2-dioxygenase; BMB171_C0217, amino acid permease; BMB171_C0218, MFS transporter. The vector pBMB3141, a derivative of pBMBL, contained the hmgA gene (1,173 bp) amplified from the genomic DNA of BMB171 by using primers hmgA1...”
EP10_000138 amino acid permease from Geobacillus icigianus
39% identity, 65% coverage
- The Transcriptomic Response of Cells of the Thermophilic Bacterium <i>Geobacillus icigianus</i> to Terahertz Irradiation
Peltek, International journal of molecular sciences 2024 - “...carboxylic acid transporter gene (EP10_002156) and genes encoding transporters of glutamine and other amino acids (EP10_000138, EP10_001536, EP10_002622, EP10_00263, EP10_002624, and EP10_002625). These data indicate the beginning of a recovery of systems responsible for the utilization of amino acids and of other carbon sources from the...”
- “...0.1) 10 min after THz irradiation of G. icigianus cells. Locus ID log2FoldChange padj Protein/Enzyme EP10_000138 1.355826 0.000163 Putative amino acid permease YhdG EP10_000693 0.863538 0.084168 5-oxoprolinase subunit A EP10_001536 0.875392 0.066384 Glutamine-binding periplasmic protein EP10_002112 0.894702 0.098217 Threonine synthase EP10_002113 1.012461 0.041217 Homoserine kinase EP10_002156...”
CAAT1_ARATH / Q84MA5 Cationic amino acid transporter 1; Amino acid transporter 1 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
AT4G21120 AAT1 (AMINO ACID TRANSPORTER 1); L-glutamate transmembrane transporter/ L-lysine transmembrane transporter/ arginine transmembrane transporter/ cationic amino acid transmembrane transporter from Arabidopsis thaliana
29% identity, 95% coverage
- function: High-affinity permease involved in the transport of the cationic amino acids (e.g. arginine, lysine, histidine, citrulline, valine, and glutamate). Transport mostly basic amino acids, and, to a lower extent neutral and acidic amino acids. May function as a proton symporter.
- Fine-Tuning of Arabidopsis thaliana Response to Endophytic Colonization by Gluconacetobacter diazotrophicus PAL5 Revealed by Transcriptomic Analysis
Soares, Plants (Basel, Switzerland) 2024 - “...one urea transporter gene (DUR3, at5g45380), and three amino acid transporter genes (CAT5, at2g34960; CAT1, at4g21120; and APP3, at1g77380) were induced. The amino acid transporter gene (APP7, at5g23810) was repressed in shoots. In the nitrogen assimilation pathway, the NIA1 gene (at1g77760), which encodes the enzyme nitrate...”
- The Root-Colonizing Endophyte Piriformospora indica Supports Nitrogen-Starved Arabidopsis thaliana Seedlings with Nitrogen Metabolites
Scholz, International journal of molecular sciences 2023 - “...Amino acid (CAT family) GAT1/BAT1 At1g08230 x 2.02 x X Amino acid (CAT family) CAT1/AAT1 At4g21120 1.65 3.39 x X Amino acid (CAT family) CAT5 At2g34960 x 2.18 x X Amino acid (UmamiT family) UmamiT 4 At3G18200 x 4.31 x X Amino acid (UmamiT family) UmamiT...”
- Molecular mechanisms of resistance to Myzus persicae conferred by the peach Rm2 gene: A multi-omics view
Le, Frontiers in plant science 2022 - “...Glutamate synthase 1 Prupe_6G054800 AT3G47340 85 Yes 4.5 1.10E-29 ASN1; Asparagine synthetase [glutamine-hydrolyzing] 1 Prupe_4G089000 AT4G21120 72 Yes 4.0 3.80E-33 CAT1; Cationic amino acid transporter 1 Prupe_3G211600 AT3G21670 74 Yes 1.4 3.70E-02 NPF6.4; Protein NRT1/PTR FAMILY 6.4 Prupe_1G052400 AT4G13510 80 Yes 1.8 2.10E-07 AMT1; Ammonium transporter...”
- Membrane nanodomains and transport functions in plant
Martinière, Plant physiology 2021 - “...column. Transported molecules Protein/Protein family Accessions Tissues References Amino acids Cationic amino acid transporter (CAT) AT4G21120 (CAT1) Suspension cell cultures Keinath et al., 2010 Lysine histidine transporter (LHT) AT5G40780 (LTH1) Suspension cell cultures Keinath et al., 2010 Ammonium Ammonium transporter (AMT) AT4G13510 (AMT1;1) ; AT2G38290 (AMT2)...”
- Dynamic Development of White Lupin Rootlets Along a Cluster Root
Le, Frontiers in plant science 2021 - “...Gene description Element Profile number Lalb_Chr20g0113031 AT2G37330 Aluminum sensitive 3 (ALS3) Aluminum Profile 5 Lalb_Chr07g0185661 AT4G21120 Amino acid transporter 1 (AAT1) Amino acid Profile 6 Lalb_Chr14g0363171 AT5G40780 Lysine histidine transporter 1 (LHT1) Amino acid Profile 6 Lalb_Chr03g0042381 AT3G09330 Amino acid transporter (AVT1G) Amino acid Profile 6...”
- Differential Alternative Splicing Genes and Isoform Regulation Networks of Rapeseed (Brassica napus L.) Infected with Sclerotinia sclerotiorum
Ma, Genes 2020 - “...only expressed in the resistant cultivars when induced by the pathogen. BnaA03g58530D is homologous to AT4G21120 , which encodes an amino acid transporter 1 (AAT1). This gene was DAS in the mock-treated and infected resistant cultivar J4 at 24 hpi, and between the susceptible and resistant...”
- “...J4_24 h\J4_24 h vs. J4_ck BnaA09 g19610D AT3G25840 K9I22.6 73.57 Protein kinase superfamily protein BnaA03g58530D AT4G21120 90.05 Amino acid transporter 1 J2_24 h vs. J4_24 h\J4_48 h vs. J4_ck BnaC02g27060D AT4G02620 87.23 Vacuolar ATPase subunit F protein J4_24 h vs. J4_ck BnaC06g34460D AT1G73650 F25P22.29 88.66 Protein...”
- Integrated Transcriptional and Proteomic Profiling Reveals Potential Amino Acid Transporters Targeted by Nitrogen Limitation Adaptation
Liao, International journal of molecular sciences 2020 - “...transporter (AtLHT1) NC 18.65 0.001 At4g35180 amino acid transporter family protein (AtLHT7) NC 15.02 0.001 At4g21120 cationic amino acid transporter (AtCAT1) NC 6.21 0.002 At2g38290 high-affinity ammonium transporter 2 (AMT2) NC 3.75 0.004 At1g31830 amino acid permease family protein (AtPUT2/AtPQR2) NC 2.93 0.002 At5g63850 amino acid...”
- Genome-Wide Transcriptome Analysis Reveals Conserved and Distinct Molecular Mechanisms of Al Resistance in Buckwheat (Fagopyrum esculentum Moench) Leaves
Chen, International journal of molecular sciences 2017 - “...(KAT1) K + comp69280_c0_seq1 1.332 AT3G18830 Polyol/monosaccharide transporter 5 Linear polyols; myo-inositol; monosaccharides comp7769_c0_seq1 1.787 AT4G21120 Cationic amino acid transporter 1 Lys, Arg and Glu comp10794_c0_seq1 1.790 comp13115_c0_seq1 1.429 comp8282_c0_seq1 1.398 comp25372_c0_seq1 1.911 comp32005_c0_seq2 1.502 AT1G25480 Aluminum-activated malate transporter family protein Malate comp33002_c0_seq1 1.168 AT1G77210 Sugar...”
- More
- Plasma membrane receptor-like kinases and transporters are associated with 2,4-D resistance in wild radish
Goggin, Annals of botany 2020 - “...* Cationic amino acid transporter 1, CAT1 (Q84MA5) Putative receptor-like kinase At5g39000 (Q9FID8) ABC transporter G family member 35, ABCG35 (Q7PC86)*...”
- Proteomic and Transcriptomic Analyses Indicate Metabolic Changes and Reduced Defense Responses in Mycorrhizal Roots of Oeceoclades maculata (Orchidaceae) Collected in Nature
Valadares, Journal of fungi (Basel, Switzerland) 2020 - “...Q42400, FC = 51.7 and IDQ38967, FC = 1.7), a cationic amino acid transporter (ID Q84MA5, FC = 6.7), and a lysine histidine transporter (ID Q9FKS8, FC = 4.5), all likely located on the plasma membrane, were also up-regulated in Myc roots ( Table S7 )....”
6f34A / Q5L1G5 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine. (see paper)
38% identity, 65% coverage
- Ligands: peptide; arginine; cholesterol (6f34A)
GBAA0593 amino acid permease family protein from Bacillus anthracis str. 'Ames Ancestor'
36% identity, 64% coverage
MTRTR_BACSU / Q797A7 Methylthioribose transporter from Bacillus subtilis (strain 168) (see paper)
35% identity, 64% coverage
- function: Involved in import of methylthioribose (MTR) into the cell.
disruption phenotype: Disruption of the gene leads to almost full resistance to trifluoromethylthioribose (3FMTR), a toxic analog of MTR.
BA3141 amino acid permease family protein from Bacillus anthracis str. Ames
35% identity, 64% coverage
XF2207 cationic amino acid transporter from Xylella fastidiosa 9a5c
36% identity, 62% coverage
LOC102626651 cationic amino acid transporter 1 from Citrus sinensis
34% identity, 64% coverage
- Hub Genes and Pathways Related to Lemon (Citrus limon) Leaf Response to Plenodomus tracheiphilus Infection and Influenced by Pseudomonas mediterranea Biocontrol Activity
Sicilia, International journal of molecular sciences 2024 - “...the central part of the network, including PIN (Cluster-5871.3), Cyt-p450 (Cluster-6461.16030), PHO84 (Cluster-6461.10355), ndh1 (Cluster-6461.23594), LOC102626651 (Cluster-6461.3793) and three receptor-like kinases (RLK): HERK1 (Cluster-6461.1373), CLAVATA1 (Cluster-6461.9951) and LRR (Cluster-6461.18390). Due to their high neighborhood connectivity and module membership values, they could be considered candidate hub genes...”
- “...five associated genes in the central part of the network PIN, Cyt-p450, PHO84, SLC15A3_4, ndh1, LOC102626651 in the 3CPt vs.CK samples. It is important to mention that receptor-like kinases (RLK) are not hub genes in the 3CPt vs. CK. Moreover, these gene networks reveal that 6:...”
Q5L1G5 Amino acid transporter from Geobacillus kaustophilus (strain HTA426)
38% identity, 65% coverage
CAAT9_ARATH / Q9C5D6 Cationic amino acid transporter 9, chloroplastic from Arabidopsis thaliana (Mouse-ear cress) (see paper)
AT1G05940 CAT9 (CATIONIC AMINO ACID TRANSPORTER 9); cationic amino acid transmembrane transporter from Arabidopsis thaliana
30% identity, 91% coverage
- function: Permease involved in the transport of the cationic amino acids.
- Cellular export of sugars and amino acids: role in feeding other cells and organisms
Kim, Plant physiology 2021 - “..., AAP family protein PUT1 (At1g31820), AAP1 (At1g58360), cationic amino acid transporters CAT4 (At3g03720), CAT9 (At1g05940), and CAT2 (At1g58030) is indicated. The logit score for UmamiT45 was 14.2. Figure 4 The role of SWEETs and UmamiTs in Arabidopsis, rice, and maize. A, The role of SWEETs...”
- Transcriptome-Wide Analysis of Nitrogen-Regulated Genes in Tea Plant (Camellia sinensis L. O. Kuntze) and Characterization of Amino Acid Transporter CsCAT9.1
Zhang, Plants (Basel, Switzerland) 2020 - “...6 , it was observed that the growth of OE lines with Arabidopsis cat mutant (AT1G05940) background was comparable with the growth of the WT and the Arabidopsis cat mutant, particularly with respect to rosette leaves. The growth inhibition of OE lines in WT background was...”
- Species-Wide Variation in Shoot Nitrate Concentration, and Genetic Loci Controlling Nitrate, Phosphorus and Potassium Accumulation in Brassica napus L
Alcock, Frontiers in plant science 2018 - “...Cab002494.2 AT2G30320 3 10 207 Pseudouridine synthase family protein A3 GEM_Cab002494.2 Leaf K concentration Cab037725.3 AT1G05940 9 10 237 CATIONIC AMINO ACID TRANSPORTER 9 A9 GEM_Cab037664.1 Leaf K concentration Cab007712.1 AT5G10740 2 10 151 Protein phosphatase 2C family protein A10 GEM_Cab007712.1 Leaf K concentration Bo9g003730.1 AT4G01080...”
- “...0.0 CYTOCHROME P450, FAMILY 86, SUBFAMILY A, POLYPEPTIDE 2 C9 GEM_Bo9g002280.1 Leaf K concentration Bo9g001030.1 AT1G05940 6 10 143 CATIONIC AMINO ACID TRANSPORTER 9 C9 GEM_Bo9g002280.1 Leaf K concentration Bo9g171810.1 AT5G10740 3 10 47 Protein phosphatase 2C family protein C9 GEM_Bo9g171810.1 Putative functions obtained from annotation...”
- The putative Cationic Amino Acid Transporter 9 is targeted to vesicles and may be involved in plant amino acid homeostasis
Yang, Frontiers in plant science 2015 - “...without nitrogen for 24 further weeks. DNA Cloning The full cDNA sequence of CAT9 ( At1g05940 ) that missed the STOP codon was cloned via BamHI and SmaI using the pCRblunt kit (Invitrogen) and inserted 5 in frame of the GFP sequence in a plant binary...”
- A tonoplast Glu/Asp/GABA exchanger that affects tomato fruit amino acid composition
Snowden, The Plant journal : for cell and molecular biology 2015 - “...(Table S1) and is a homologue of Arabidopsis thaliana cationic amino acid transporter 9 (CAT9; At1g05940; NP_563754.1). Whilst members of the CAT subfamily of transporters predominantly transport cationic amino acids, plasmamembranelocalised members of this family from Arabidopsis have been shown to possess the capacity for the...”
- The AAP gene family for amino acid permeases contributes to development of the cyst nematode Heterodera schachtii in roots of Arabidopsis
Elashry, Plant physiology and biochemistry : PPB 2013 - “...0.6 0.03 At3g10600 AtCAT7 3.3 3 0.3 0.20 At1g17120 AtCAT8 6.5 5.6 0.9 a 0.00 At1g05940 AtCAT9 8.1 7 1.1 a 0.00 At5g05630 AtLAT1 3.5 3.7 0.2 0.43 At3g13620 ATLAT2 5.1 7 1.9 a 0.00 At1g31820 AtLAT3 4.6 3.9 0.7 0.07 At1g31830 AtLAT4 8.1 7.5 0.6...”
- A proteomics dissection of Arabidopsis thaliana vacuoles isolated from cell culture
Jaquinod, Molecular & cellular proteomics : MCP 2007 - “...46 KuP 2d Transp. NF NF At5g40670 At1g05940 At1g58030 At3g03720 At1g17120 At3g30390 At2g41190 At2g39130 At2g40420 At3g28960 At1g70330 31,007 60,138 67,072...”
lin0648 similar to amino acid transporter from Listeria innocua Clip11262
35% identity, 64% coverage
lmo0645 similar to amino acid transporter from Listeria monocytogenes EGD-e
35% identity, 64% coverage
LOC18050423 cationic amino acid transporter 7, chloroplastic from Citrus x clementina
29% identity, 91% coverage
lpg0026 amino acid permease from Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Q5ZZI4 Amino acid permease from Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
34% identity, 66% coverage
- Mammalian Solute Carrier (SLC)-like transporters of Legionella pneumophila
Best, Scientific reports 2018 - “...other monosaccharides SLC2a1 (0.903) LstB (Lpg1653) 30% 48% Glucose and other monosaccharides SLC2a1 (0.922) LstC (Lpg0026) 37% 56% Cationic amino acids (arginine, lysine, ornithine) SLC7a1 (0.953) LstD (Lpg0049) 25% 44% Cationic amino acids (arginine, lysine, ornithine) SLC7a5 (0.954) LstE (Lpg0228) 25% 42% Cationic amino acids (arginine,...”
- bdhA-patD operon as a virulence determinant, revealed by a novel large-scale approach for identification of Legionella pneumophila mutants defective for amoeba infection
Aurass, Applied and environmental microbiology 2009 - “...scatter screena Closest homolog (organism) E value lpg0026 lpg0072 lpg0129 lpg0166 lpg0200 lpg0230 lpg0233 lpg0237 lpg0243 lpg0265 lpg0277 lpg0493 lpg0515...”
- Proteome Exploration of Legionella pneumophila To Identify Novel Therapeutics: a Hierarchical Subtractive Genomics and Reverse Vaccinology Approach
Khan, Microbiology spectrum 2022 - “...cefoperazone, cefazolin, amdinocillin, cefonicid, cefepime, ceftibuten, mezlocillin, ceftazidime, ertapenem, and doripenem 486.493 612 7 tr| Q5ZZI4 Amino acid permease DB00123, DB00125, and DB00129 l -Lysine, l -arginine, and ornithine 155.606 424 a Drug names correspond respectively to the DrugBank ID numbers listed in Table 3, column...”
lpp0026 hypothetical protein from Legionella pneumophila str. Paris
34% identity, 66% coverage
Q8P9N1 Cationic amino acid transporter from Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)
34% identity, 64% coverage
lp_0861 amino acid transport protein (putative) from Lactobacillus plantarum WCFS1
31% identity, 63% coverage
CAAT6_ARATH / Q9LZ20 Cationic amino acid transporter 6, chloroplastic from Arabidopsis thaliana (Mouse-ear cress) (see paper)
TC 2.A.3.3.4 / Q9LZ20 The amino acid transporter, CAT6. Mediates electrogenic transport of large neutral and cationic amino acids in preference to other amino acids. Present in lateral root primordia, flowers and seeds from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
T1E3_130 / GI|13430548 amino acid transport-like protein from Arabidopsis thaliana (see paper)
AT5G04770 CAT6 (CATIONIC AMINO ACID TRANSPORTER 6); amino acid transmembrane transporter/ basic amino acid transmembrane transporter/ cationic amino acid transmembrane transporter from Arabidopsis thaliana
30% identity, 92% coverage
- function: Permease involved in the transport of the cationic neutral or acidic amino acids.
- substrates: Amino acids
- Insights into the Structure, Function, and Ligand Discovery of the Large Neutral Amino Acid Transporter 1, LAT1
Singh, International journal of molecular sciences 2018 - “...(UniProt accession number: Q01650, organism: Human), LAT2 (Q9UHI5, Human), Uga4 (P32837, Saccharomyces cerevisiae ), Cat6 (Q9LZ20, Arabidopsis thaliana ), GadC (P63235, Escherichia coli ), AdiC (P60061, E. coli ), CadB (P0AAE8, E. coli ), and PotE (P0AAF1, E. coli ). The multiple sequence alignment and phylogenetic...”
- Genetic Mapping and Identification of the Candidate Gene for White Seed Coat in Cucurbita maxima
Shi, International journal of molecular sciences 2021 - “...and is required for ABA signaling in Arabidopsis CmaCh15G005280 2441111~2445124 Cationic amino acid transporter 7 AT5G04770 Cationic amino acid transporter (CAT) subfamily of amino acid polyamine choline transporters CmaCh15G005290 2449424~2462027 Pentatricopeptide repeat-containing protein AT5G04780 Pentatricopeptide repeat (PPR) superfamily protein CmaCh15G005300 2463445~2466291 Double Clp-N motif-containing P-loop nucleoside...”
- Comparison of efficiency and specificity of CRISPR-associated (Cas) nucleases in plants: An expanded toolkit for precision genome engineering
Raitskin, PloS one 2019 - “...(30) N (1) Y (36) AT5G12180 GCATACTTGCCATTCCA|TGGGGG Y (45) Y (41) Y (39) Y (33) AT5G04770 GTCGAGACGACTAGCAC|GGCCGG Y * N * N * N * AT3G10600 GTAGAGACGACTAGCAC|GGCCGG Y * N * N * N * AT3G54020 CGACAGTGATAGTTAGG|GCCAGG Y * N * N * N * AT2G37940...”
- Genetic and Molecular Regulation of Seed Storage Proteins (SSPs) to Improve Protein Nutritional Value of Oilseed Rape (Brassica napus L.) Seeds
Gacek, Frontiers in plant science 2018 - “...et al., 2009 AT5G09220 AMINO ACID PERMEASE 2 Amino acid transport Zhang et al., 2010 AT5G04770 cationic amino acid transporter Amino acid transport Hammes et al., 2006 AT1G10010 AMINO ACID PERMEASE 8 Amino acid transport Schmidt et al., 2007 AT2G02040 PEPTIDE TRANSPORTER 2 Peptide transport Song...”
- The Arabidopsis NLP7 gene regulates nitrate signaling via NRT1.1-dependent pathway in the presence of ammonium
Zhao, Scientific reports 2018 - “...transporter; OPT3; ortholog AT3G54830 Amino acid transporter; At3g54830; ortholog AT5G24920 Glutamine dumper 5; GDU5; ortholog AT5G04770 Cationic amino acid transporter 6; CAT6; ortholog AT5G47450 Tonoplast intrinsic protein 2;3; TIP2;3; ortholog AT1G12940 Nitrate transporter 2.5; NRT2.5; ortholog Table 4 GO analysis for the genes regulated only by...”
- GpDSR7, a Novel E3 Ubiquitin Ligase Gene in Grimmia pilifera Is Involved in Tolerance to Drought Stress in Arabidopsis
Li, PloS one 2016 - “...GpDSR14 5 810 Phospholipase D At4g35790 J GpDSR15 5 1006 Cationic amino acid transmembrane transporter At5g04770 B GpDSR16 5 1079 Hyperosmolality-gated calcium-permeable channel At4g04340 P GpDSR17 5 1186 Erythronate-4-phosphate dehydrogenase family protein At1g75180 P GpDSR18 5 1071 EXS family protein At5g35730 P GpDSR19 5 567 Sodium/hydrogen...”
- The AAP gene family for amino acid permeases contributes to development of the cyst nematode Heterodera schachtii in roots of Arabidopsis
Elashry, Plant physiology and biochemistry : PPB 2013 - “...1.8 a 0.00 At3g03720 AtCAT4 6.7 5.4 1.3 0.03 At2g34960 AtCAT5 3.5 3.1 0.4 0.24 At5g04770 AtCAT6 5.3 5.9 0.6 0.03 At3g10600 AtCAT7 3.3 3 0.3 0.20 At1g17120 AtCAT8 6.5 5.6 0.9 a 0.00 At1g05940 AtCAT9 8.1 7 1.1 a 0.00 At5g05630 AtLAT1 3.5 3.7 0.2...”
- Iron-dependent modifications of the flower transcriptome, proteome, metabolome, and hormonal content in an Arabidopsis ferritin mutant
Sudre, Journal of experimental botany 2013 - “...transporter family protein At3g59030 1.9 DTX41 , TT12 (transparent testa), putative vacuolar flavonoid/H + antiporter At5g04770 1.3 CAT6 , cationic/basic amino acid transmembrane transporter At1g30690 1.4 SEC14, cytosolic factor family protein/phosphoglyceride transfer family At1g08430 1.5 ALMT1, aluminium-activated malate transporter At4g17260 Others 1.4 l -Lactate dehydrogenase, putative...”
- “...( Liu et al. , 2009 , 2012 ). The other up-regulated gene was CAT6 (At5g04770), a putative cationic amino acid transporter. Down-regulated transporter genes were: the ABC-transporter ABCG10 (At1g53270); DTX41 (At3g59030), a putative vacuolar flavonoid/H+ antiporter of the MATE family; and a Sec14p-like phosphatidylinositol transfer...”
- Host origin of plastid solute transporters in the first photosynthetic eukaryotes
Tyra, Genome biology 2007 - “...channel 1 (ATKC1) At4g38380 Multi antimicrobial extrusion (MATE Efflux) protein At4g39460 S-adenosylmethionine carrier 2 (SAMT) At5g04770 Amino acid permease At5g05630 Amino acid permease At5g13550 Sulfate transporter At5g14040 Mitochondrial phosphate transporter At5g16150 Hexose transporter At5g17630 Glucose-6-phosphate transporter 1 (XPT) At5g19410 ABC transporter (White) At5g19600 Sulfate transporter At5g22830...”
LOC105052094 cationic amino acid transporter 6, chloroplastic from Elaeis guineensis
30% identity, 94% coverage
- Genes, pathways and networks responding to drought stress in oil palm roots
Wang, Scientific reports 2020 - “...Up LOC105044259 Serine/threonine protein kinase OSK1 Up Nitrate assimilation LOC105037451 Amino acid permease 8 Down LOC105052094 Cationic amino acid transporter 6, chloroplastic Up LOC105032563 Vacuolar cation/proton exchanger 1a Down LOC105038946 Sodium/hydrogen exchanger 3 Up Transcription factors in drought responses To date, more and more studies focused...”
LSA0189 Putative amino acid/polyamine transport protein from Lactobacillus sakei subsp. sakei 23K
32% identity, 65% coverage
- Global transcriptome response in Lactobacillus sakei during growth on ribose
McLeod, BMC microbiology 2011 - “...transport and metabolism Transport/binding of amino acids LSA0125 lsa0125 Putative amino acid/polyamine transport protein 0.6 LSA0189 lsa0189 Putative amino acid/polyamine transport protein -0.7 LSA0311 lsa0311 Putative glutamate/aspartate:cation symporter -1.1 -1.0 LSA1037 lsa1037 Putative amino acid/polyamine transport protein 1.0 0.8 0.5 LSA1219 lsa1219 Putative cationic amino acid...”
LOC110863868 cationic amino acid transporter 1 from Helianthus annuus
34% identity, 64% coverage
- Dissecting the Genetic Architecture of Morphological Traits in Sunflower (Helianthus annuus L.)
Delen, Genes 2024 - “...10 were shared by both models. The SNP NC_035433.2-12278968 was closely located to two genes (LOC110863868 and LOC110863881) in the results of both methods. Similarly, another SNP, NC_035441.2-99824358, was closely located to two genes, LOC110875903 and LOC110875902. The genes that were identified by the MLM method...”
- “...chromosomes 1, 9, and 10, were shared by both models. Among these genes, the gene LOC110863868 was functioning in coding cationic amino acid transporter 1, which is an amino acid transporter that plays a significant role in nitrogen distribution throughout the plant, which is necessary to...”
SCO6014 cationic amino acid transporter from Streptomyces coelicolor A3(2)
35% identity, 64% coverage
- Functional connexion of bacterioferritin in antibiotic production and morphological differentiation in Streptomyces coelicolor
García-Martín, Microbial cell factories 2024 - “...g io s pore m aturation cell wall hydrolase ) domain [ 126 ], and SCO6014, a putative amino acids transporter [ 127 ], were more abundant in the mutant, while SCO5207, a putative regulatory protein from cystathionine beta-synthase family [ 126 ], was less abundant....”
- Cross-Recognition of Promoters by the Nine SigB Homologues Present in Streptomyces coelicolor A3(2)
Sevcikova, International journal of molecular sciences 2021 - “...them may have a function in osmoprotection, for example a possible transporter for amino acids SCO6014. Furthermore, proteins involved in cell wall biogenesis (SCO0565, SCO2509, SCO3557, SCO5998) may also increase tolerance to osmotic stress. Interestingly, the rrnE operon for 16S, 23S, 5S rRNA is also partially...”
- “...septum site determining protein, all othermembrane HP SCO5749 atypical response regulator SCO5998 putative UDP-N-acetylglucosamine transferase SCO6014 putative cationic amino acid transporter SCO6509 hydrophobic protein SCO7446 putative regulator rrnE 16S, 23S, 5S rRNA operon HP, Hypothetical protein. ijms-22-07849-t002_Table 2 Table 2 Comparison of promoters dependent on several...”
- Initial Metabolic Step of a Novel Ethanolamine Utilization Pathway and Its Regulation in Streptomyces coelicolor M145
Krysenko, mBio 2019 - “...in S. coelicolor M145 allowed in silico identification of two putative ethanolamine/amino acid permease genes, SCO6014 and SCO5977 , with rather low similarity to the putative ethanolamine permease target from other Streptomycetes spp. (43% to 45%). To verify whether the expression of SCO6014 and SCO5977 might...”
- “...the presence of ethanolamine and ammonium (control) as the sole N source. Transcriptional analysis of SCO6014 and SCO5977 revealed strong expression of these genes in the presence of ammonium, whereas no expression was observed in the presence of ethanolamine under the tested conditions (see Fig.S1 in...”
XP_039279453 high affinity cationic amino acid transporter 1-like isoform X1 from Nilaparvata lugens
30% identity, 76% coverage
AT3G10600 CAT7 (CATIONIC AMINO ACID TRANSPORTER 7); cationic amino acid transmembrane transporter from Arabidopsis thaliana
Q9SQZ0 Cationic amino acid transporter 7, chloroplastic from Arabidopsis thaliana
30% identity, 92% coverage
LOC101509123 cationic amino acid transporter 5 from Cicer arietinum
28% identity, 93% coverage
Minf_1788 Amino acid transporter from Methylacidiphilum infernorum V4
34% identity, 63% coverage
Q7NK14 Gll1666 protein from Gloeobacter violaceus (strain ATCC 29082 / PCC 7421)
36% identity, 63% coverage
B1745_03815 APC family permease from Lactobacillus amylolyticus
33% identity, 64% coverage
- Adaptive mechanism of Lactobacillus amylolyticus L6 in soymilk environment based on metabolism of nutrients and related gene-expression profiles
Fei, Food science & nutrition 2022 - “...ligase 1.22 B1745_01405 secY preprotein translocase subunit SecY 1.38 B1745_02435 cth aluminum resistance protein 1.74 B1745_03815 amino acid permease 2.08 John Wiley & Sons, Ltd TABLE 3 Genes differentially expressed in the stationary phase compared to logarithmic phase Function group and ORF Gene Description Expression ratio...”
- “...(B1745_03105, B1745_06875, B1745_06870, and B1745_06860) were upregulated, while two amino acid permease genes (B1745_04680 and B1745_03815) were downregulated in the logarithmic and stationary phase. Interestingly, two genes livB and brnQ coding for branchedchain amino acid transport system II carrier protein and branchedchain amino acid ABC transporter...”
EF0929 amino acid permease family protein from Enterococcus faecalis V583
33% identity, 64% coverage
CCNA_01242 amino acid permease from Caulobacter crescentus NA1000
32% identity, 64% coverage
- A Genome-Wide Analysis of Adhesion in <i>Caulobacter crescentus</i> Identifies New Regulatory and Biosynthetic Components for Holdfast Assembly
Hershey, mBio 2019 - “...uncharacterized genes from these clusters of mutants for detailed examination of holdfast defects. Disruption of CCNA_01242 , which encodes a predicted amino acid permease, led to the strongest nonadhesion fitness profile of any gene in the cheesecloth passaging experiment ( Fig.5A ). However, the CCNA_01242 strain...”
- “...significant adhesion defect under any conditions tested ( Fig.5C ; see also TableS2 ). Instead, CCNA_01242 had an unusual, biphasic growth profile. In complex medium, the log phase was shorter than that shown by the wild type, leading to a lower level of optical density (OD)...”
lmo2469 similar to amino acid transporter from Listeria monocytogenes EGD-e
34% identity, 67% coverage
- A bacterial virulence factor interacts with the splicing factor RBM5 and stimulates formation of nuclear RBM5 granules
Pourpre, Scientific reports 2022 - “...L.monocytogenes strain EGDe genome, the inlP gene (also known as lmo2470 ) is located between lmo2469 and lmo2471 , two divergently transcribed genes encoding an amino acid transporter and a NADPH dehydrogenase, respectively (Fig. 1 A). Using previous RNA-sequencing (RNA-seq) transcriptomic data from the EGDe strain...”
- Listeria monocytogenes MDR transporters are involved in LTA synthesis and triggering of innate immunity during infection
Tadmor, Frontiers in cellular and infection microbiology 2014 - “...Similar to O-acetylhomoserine sulfhydrylase Amino acids metabolism LMRG_00310.2 lmo0644 Membrane sulfatase family protein LTA LMRG_00332.2 lmo2469 Similar to amino acid transporter/amino acid permease family protein Transporters LMRG_00541.6 lmo1079 Similar to YfhO Unknown LMRG_00672.6 lmo1226 Similar to transporter ( B. subtilis YdgH); lmo1225 is a transcriptional regulator...”
- Polyphasic characterization and genetic relatedness of low-virulence and virulent Listeria monocytogenes isolates
Roche, BMC microbiology 2012 - “...previously [ 7 , 8 ]. The clpP gene and its flanking regions (lmo2467 and lmo2469) were amplified from total isolated DNA using PCR. Primers and temperature annealing are listed in the Additional file 2 . The prfA and inlA virulence genes were fully sequenced, whereas...”
- The transcriptional response of Listeria monocytogenes during adaptation to growth on lactate and diacetate includes synergistic changes that increase fermentative acetoin production
Stasiewicz, Applied and environmental microbiology 2011 - “...enzyme; lmo0689 (cheV), encoding a chemotaxis protein; lmo2469, encoding an amino acid permease; and lmo0714 (fliG), encoding a flagellar motor switch...”
- Glycerol metabolism and PrfA activity in Listeria monocytogenes
Joseph, Journal of bacteriology 2008 - “...lmo2175 fruA lmo2341 lmo2389 lmo2434 lmo2463 lmo2469 lmo2569 lmo2573b lmo2580 lmo2584a,b lmo2586a,b lmo2592 lmo2650b lmo2651a,b lmo2659a lmo2660a lmo2663a...”
- “...inlCc ilvB ilvN ilvCb ilvA lmo2114 lmo2115 arpJ lmo2390 lmo2469 glyA lmo2580 lmo2650b lmo2651 lmo2684 lmo2685 cydD cydC serS GC-B 5424 JOSEPH ET AL. J....”
- Identification of genes induced in Listeria monocytogenes during growth and attachment to cut cabbage, using differential display
Palumbo, Applied and environmental microbiology 2005 - “...catabolism Oligopeptide ABC transporter (permease) lmo2381 lmo2469 Na/pH homeostasis Amino acid transporter Transporters lmo2678 lmo2677, lmo2678 tcsA lmo1999,...”
CAAT5_ARATH / O64759 Cationic amino acid transporter 5 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
TC 2.A.3.3.12 / O64759 Cationic amino acid transporter 5 from Arabidopsis thaliana (see 3 papers)
AT2G34960 CAT5 (CATIONIC AMINO ACID TRANSPORTER 5); L-glutamate transmembrane transporter/ L-lysine transmembrane transporter/ arginine transmembrane transporter/ cationic amino acid transmembrane transporter from Arabidopsis thaliana
31% identity, 63% coverage
- function: High-affinity permease involved in the transport of the cationic amino acids (e.g. arginine, and, to a lower extent, citrulline and glutamate). Transport mostly basic amino acids, and, to a lower extent neutral and acidic amino acids.
- substrates: Amino acids
- Fine-Tuning of Arabidopsis thaliana Response to Endophytic Colonization by Gluconacetobacter diazotrophicus PAL5 Revealed by Transcriptomic Analysis
Soares, Plants (Basel, Switzerland) 2024 - “...AMT1-3, at3g24300), one urea transporter gene (DUR3, at5g45380), and three amino acid transporter genes (CAT5, at2g34960; CAT1, at4g21120; and APP3, at1g77380) were induced. The amino acid transporter gene (APP7, at5g23810) was repressed in shoots. In the nitrogen assimilation pathway, the NIA1 gene (at1g77760), which encodes the...”
- The Root-Colonizing Endophyte Piriformospora indica Supports Nitrogen-Starved Arabidopsis thaliana Seedlings with Nitrogen Metabolites
Scholz, International journal of molecular sciences 2023 - “...Amino acid (CAT family) CAT1/AAT1 At4g21120 1.65 3.39 x X Amino acid (CAT family) CAT5 At2g34960 x 2.18 x X Amino acid (UmamiT family) UmamiT 4 At3G18200 x 4.31 x X Amino acid (UmamiT family) UmamiT 8 At4G16620 x 1.99 1.69 X Amino acid (UmamiT family)...”
- Changes in annual transcriptome dynamics of a clone of Japanese cedar (Cryptomeria japonica D. Don) planted under different climate conditions
Nose, PloS one 2023 - “...1.67E-23 7.91E-23 AT3G62660 1.7E-155 GATL7 galacturonosyltransferase-like 7 temp-0h 0.88 2.38E-26 CUST_8098_PI429951308 reCj22722:-S--:isotig22574 2.57E-22 1.10E-16 4.20E-16 AT2G34960 0.0 CAT5 cationic amino acid transporter 5 temp-7d 0.88 2.65E-26 CUST_8314_PI429951308 reCj22943:-SWR:isotig22795 1.09E-16 4.80E-24 2.24E-19 AT5G58600 4.6E-114 TBL44 Plant protein of unknown function (DUF828) temp-30d 0.88 1.07E-25 CUST_7448_PI429951308 reCj22070:-S-R:isotig21922 7.94E-21...”
- Transcriptional Reprogramming of Pea Leaves at Early Reproductive Stages
Gallardo, Frontiers in plant science 2019 - “...role for CAT5 in leaf nitrogen remobilization has not yet been demonstrated, one CAT5 gene (At2g34960) was up-regulated in senescing Arabidopsis leaves (van der Graaff et al., 2006 ). The up-regulation of CAT5 in both leaf types 14 DAF and specifically in response to nitrate-deficiency 27...”
- The AAP gene family for amino acid permeases contributes to development of the cyst nematode Heterodera schachtii in roots of Arabidopsis
Elashry, Plant physiology and biochemistry : PPB 2013 - “...on GeneChip At5g36940 AtCAT3 7.8 6 1.8 a 0.00 At3g03720 AtCAT4 6.7 5.4 1.3 0.03 At2g34960 AtCAT5 3.5 3.1 0.4 0.24 At5g04770 AtCAT6 5.3 5.9 0.6 0.03 At3g10600 AtCAT7 3.3 3 0.3 0.20 At1g17120 AtCAT8 6.5 5.6 0.9 a 0.00 At1g05940 AtCAT9 8.1 7 1.1 a...”
- Computational identification of condition-specific miRNA targets based on gene expression profiles and sequence information
Joung, BMC bioinformatics 2009 - “...protein-like 9 At1g63130 miR400 0.62 Transacting siRNA generating locus At3g20910 miR169 0.62 CCAAT-binding transcription factor At2g34960 miR157 0.61 Encodes a member of the cationic amino acid transporter At1g62670 miR161 0.61 Pentatricopeptide (PPR) repeat-containing protein At3g57670* miR854 0.57 Similar to zinc finger The targets were predicted with...”
CAC3285 Predicted amino acid transporter from Clostridium acetobutylicum ATCC 824
33% identity, 63% coverage
- A genomic-library based discovery of a novel, possibly synthetic, acid-tolerance mechanism in Clostridium acetobutylicum involving non-coding RNAs and ribosomal RNA processing
Borden, Metabolic engineering 2010 - “...Although no such decarboxylase/antiporter system has yet been characterized in C. acetobutylicum , the gene CAC3285 shows 44% sequence identity with the E. coli gene gadC , while several C. acetobutylicum genes show some homology to adiA (CAC0297 [18% identity] and CAC2338 [19% identity]) and adiC...”
- “...E. coli acid decarboxylation/transport system of acid tolerance were consistently upregulated, including CAC1984,CAP0128, CAC0297 and CAC3285 ( Fig. 8 and Supplementary Fig. 6 ). As discussed earlier, CAC3285 has high similarity to gadC , which codes for a cognate glutamate/GABA antiporter in E. coli , and...”
BL105A_1680 amino acid permease from Bifidobacterium longum
34% identity, 62% coverage
GOX0025 Amino acid permease from Gluconobacter oxydans 621H
33% identity, 63% coverage
- Global mRNA decay and 23S rRNA fragmentation in Gluconobacter oxydans 621H
Kranz, BMC genomics 2018 - “...2.8 170 GOX1431 hypothetical protein 2.6 336 | GOX0024 undecaprenyl pyrophosphate phosphatase 2.6 2.8 198 GOX0025 amino acid permease 2.5 142 GOX2207 methylenetetrahydrofolate reductase 2.6 2.6 547 GOX0649 sugar-proton symporter 2.6 2.6 364 GOX2378 short chain alcohol dehydrogenase 2.6 2.6 301 GOX1151 hypothetical protein 2.5 2.5...”
CCNA_00435 L-proline transporter from Caulobacter crescentus NA1000
35% identity, 64% coverage
- mutant phenotype: Mildly important for growth with proline as the carbon or nitrogen source, and detrimental in most other conditions.
LSA1219 Putative cationic amino acid transport protein from Lactobacillus sakei subsp. sakei 23K
32% identity, 69% coverage
- Global transcriptome response in Lactobacillus sakei during growth on ribose
McLeod, BMC microbiology 2011 - “...Putative glutamate/aspartate:cation symporter -1.1 -1.0 LSA1037 lsa1037 Putative amino acid/polyamine transport protein 1.0 0.8 0.5 LSA1219 lsa1219 Putative cationic amino acid transport protein 0.7 LSA1415 lsa1415 Putative amino acid/polyamine transport protein 1.1 0.7 LSA1424 lsa1424 Putative L-aspartate transport protein -1.4 -0.9 -1.2 LSA1435 lsa1435 Putative amino...”
T1E_3208 amino acid permease from Pseudomonas putida DOT-T1E
33% identity, 64% coverage
- Insights into the susceptibility of Pseudomonas putida to industrially relevant aromatic hydrocarbons that it can synthesize from sugars
García-Franco, Microbial cell factories 2023 - “...these were found in operons related to the transport of amino acids (i.e., T1E_2666, T1E_2667, T1E_3208, T1E_0341, T1E_3315) and potassium (T1E_2369) (Additional file 7 : Table S4). While some transporters were downregulated in the presence of trans- cinnamic acid (i.e., T1E_1254, T1E_3944, T1E_0320, T1E_0710, etc.), this...”
FPSM_00250 amino acid permease from Flavobacterium psychrophilum
33% identity, 63% coverage
TC 2.A.3.3.24 / ALD51314.1 Plastidic cationic amino acid transporter, CAT, of 582 aas and 14 TMSs from Petunia x hybrida
27% identity, 89% coverage
- substrates: phenylalanine, tryptophan, tyrosine
tcdb comment: Exports phenylalanine, tyrosine and tryptophan our of chloroplasts into the cytoplasm (Widhalm et al. 2015)
ABZR86_RS06665 L-proline transporter from Dyella japonica UNC79MFTsu3.2
34% identity, 62% coverage
- mutant phenotype: Mildly important for growth with proline as the carbon source, but not in other conditions
Mvan_1740 amino acid permease-associated region from Mycobacterium vanbaalenii PYR-1
37% identity, 64% coverage
LOC18049397 cationic amino acid transporter 6, chloroplastic from Citrus x clementina
29% identity, 91% coverage
MAP3365c hypothetical protein from Mycobacterium avium subsp. paratuberculosis str. k10
35% identity, 64% coverage
JTY_3278 putative cationic amino acid transport integral membrane protein from Mycobacterium bovis BCG str. Tokyo 172
BCG_3282c putative cationic amino acid transport integral membrane protein from Mycobacterium bovis BCG str. Pasteur 1173P2
Rv3253c POSSIBLE CATIONIC AMINO ACID TRANSPORT INTEGRAL MEMBRANE PROTEIN from Mycobacterium tuberculosis H37Rv
36% identity, 63% coverage
- Deep sequencing analysis of the heterogeneity of seed and commercial lots of the bacillus Calmette-Guérin (BCG) tuberculosis vaccine substrain Tokyo-172
Wada, Scientific reports 2015 - “...). For example, Breseq failed to consistently detect variations at positions 644,562 (JTY_0567) and 3,606,131 (JTY_3278), although these variations were detected by LoFreq and SNVer. To apply this method to other substrains, a reference sequence must be applied by integration of several genomes to account for...”
- “...3,192,638 . A . . . pps A frameshift 3,606,131 G A A A A JTY_3278 T54I 4,087,391 C T T T T JTY_3735 A184V * Correspondent to nucleotide positions of genome sequence of M. bovis BCG Tokyo Type I (Accesion No. NC012207). Left gene: clp...”
- Methionine Antagonizes para-Aminosalicylic Acid Activity via Affecting Folate Precursor Biosynthesis in Mycobacterium tuberculosis
Howe, Frontiers in cellular and infection microbiology 2018 - “...al., 2007 M. bovis BCG Pasteur metM :: himar1 Transposon insertion mutant with disruption in BCG_3282c ( metM ) This work M. bovis BCG Pasteur metM :: himar1 / pUMN002hyg:: metM Complemented BCG_3282c ( metM ) transposon insertion mutant This work M. bovis BCG Pasteur bioB...”
- “...Sbf I or Afl II and ligated to produce pUMN002hyg. The metM coding region ( BCG_3282c ) was amplified from M. bovis BCG genomic DNA by PCR with primers BCG3282c _ For and BCG3282c_Rev (Supplementary Table S1 ), digested with Nhe I and Eco RI, and...”
- Comparative transcriptional study of the putative mannose donor biosynthesis genes in virulent Mycobacterium tuberculosis and attenuated Mycobacterium bovis BCG strains
Keiser, Infection and immunity 2011 - “...(forward) GCGAACAAGACCAGGCATATG (reverse) Rv3253c, BCG_3282c 53c CCAACTACTCGCCGTTCATT (forward) GCAGTTGGGTGTATGGAACC (reverse) Rv3255c, BCG_3284c manA...”
- Mutations in the promoter region of methionine transporter gene metM (Rv3253c) confer para-aminosalicylic acid (PAS) resistance in Mycobacterium tuberculosis
Zhang, mBio 2024 - “...Research Article antimicrobial-chemotherapy Antimicrobial Chemotherapy Mutations in the promoter region of methionine transporter gene metM (Rv3253c) confer para -aminosalicylic acid (PAS) resistance in Mycobacterium tuberculosis https://orcid.org/0000-0002-1737-5891 Zhang Yu 1 Data curation Formal analysis Investigation Methodology Validation Visualization Writing original draft Writing review and editing Wang Shiyong...”
- “...90 (52.2%) PAS-resistant mutants had nine different mutations in the intergenic region of metM ( Rv3253c ) and Rv3254 . Beta-galactosidase assays confirmed that mutations increased promoter activity only for metM but not Rv3254 . Interestingly, overexpression of MetM or its M. smegmatis homolog (MSMEI_1796) either...”
- M. tuberculosis AlkX Encoded by rv3249c Regulates a Conserved Alkane Hydroxylase System That Is Important for Replication in Macrophages and Biofilm Formation
Stokas, Microbiology spectrum 2022 - “...transcribed as an operon. There are only 108 bases between the stop codon of the rv3253c gene and the start codon of alkB . To determine if alkB-rubAB is cotranscribed, and assess whether rv3253c is also part of the operon, we performed reverse transcriptase PCR (RT-PCR)....”
- “...AlkX with the promoter region upstream of rv3252c ( alkB ), but not that of rv3253c . Reactions were performed with 6nM Dig-labeled probe and the indicated micromolar concentrations of protein. To demonstrate specificity, the Rv3252c EMSA was performed in the presence of nonlabeled (cold) probe...”
- Multi-omics comparisons of p-aminosalicylic acid (PAS) resistance in folC mutated and un-mutated Mycobacterium tuberculosis strains
Wei, Emerging microbes & infections 2019 - “...SNPs (3074495 GA, located in between thyA and Rv2765 and 3633617 CT, located in between Rv3253c and Rv325 4) identified in this study, were inserted into the pSD5B mycobacterial shutter vector that contains a promoterless lacZ reporter gene immediately downstream of the cloning site and -D-galactosidase...”
- “...downstream genes. thyA , drfA and hsdS are located in the downstream of 3074495 SNP, Rv3253c is located in in the downstream of 3633617 SNP and lpdA , glpD2 , Rv3304 , amiA1 , amiB1 are located in the downstream of VNTR 3690 locus. Data were...”
- Methionine Antagonizes para-Aminosalicylic Acid Activity via Affecting Folate Precursor Biosynthesis in Mycobacterium tuberculosis
Howe, Frontiers in cellular and infection microbiology 2018 - “...PAS susceptibility a Growth on PAS-Met b M. bovis BCG Wild-type no ++++ BCG_3282c ( Rv3253c ) Amino acid permease no ftsH ( ftsH ) Membrane-bound protease (insertion located near upstream folate biosynthesis operon) yes + bioB ( bioB ) Biotin synthase involved in biotin biosynthesis...”
- “...in the Mycobacterium genus, sharing 100% sequence identity with numerous M. tuberculosis complex organisms including Rv3253c , an ortholog from the virulent reference strain H37Rv. However, no close orthologs of metM have been structurally or functionally characterized thus far. To confirm whether metM disruption altered methionine...”
- Inhibition of apoptosis by Rv2456c through Nuclear factor-κB extends the survival of Mycobacterium tuberculosis
Jurcic, International journal of mycobacteriology 2016 - “...Probable hypothetical membrane protein 7 Rv1436 gap Involved in the 2nd phase of glycolysis 8 Rv3253c Possible cationic amino acid transport integral membrane protein 9 Rv0876c Possible conserved transmembrane protein 10 Rv0110 Probable conserved integral membrane transport protein 11 Rv2019 Unknown, conserved protein 12 Rv1624c Probable...”
- Systems biology-based identification of Mycobacterium tuberculosis persistence genes in mouse lungs
Dutta, mBio 2014 - “..., Rv0662c , fabG ( Rv2766c ), dinF ( Rv2836c ), ppsC ( Rv2933 ), Rv3253c , aspB ( Rv3565 ) 9 Null Untested Null ppsA ( Rv2931 ), ppsB ( Rv2932 ), ppsD ( Rv2934 ), Rv3273 4 Null Untested Untested rodA ( Rv0017c )...”
- Comparative transcriptional study of the putative mannose donor biosynthesis genes in virulent Mycobacterium tuberculosis and attenuated Mycobacterium bovis BCG strains
Keiser, Infection and immunity 2011 - “...Rv3256c and Rv3258c (both hypothetical proteins), and Rv3253c (a postulated membrane flippase), whose functions are unknown but which are potentially...”
- “...the other genes of interest with unknown functions, Rv3253c, Rv3256c, and Rv3258c, used for the transcriptional expression study. 4670 KEISER ET AL. INFECT....”
- Physiology of mycobacteria
Cook, Advances in microbial physiology 2009 - “...M. tuberculosis has several genes encoding putative L-arginine uptake transporters: Rv0522, Rv1979c, Rv1999c, Rv2320c and Rv3253c ( Cole et al. , 1998 ). Transport of L-arginine, but not of L-lysine and L-ornithine, was reduced by 70% in a mutant of M. bovis BCG lacking the gene...”
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lp_3278 amino acid permease from Lactiplantibacillus plantarum WCFS1
F9UTG8 Amino acid transport protein from Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
lp_3278 amino acid transport protein from Lactobacillus plantarum WCFS1
34% identity, 67% coverage
- Transcriptional analysis of the molecular mechanism underlying the response of Lactiplantibacillus plantarum to lactic acid stress conditions
Jang, Heliyon 2023 - “...both acidic conditions. Membrane proteins (lp_1684, lp_3080, lp_2949, lp_3178, lp_3177, lp_0309, lp_1946), amino acid transporter (lp_3278), and manganese ABC transporter (lp_2992) were up-regulated, and cold shock protein (lp_1160, lp_0997), carbohydrate proton transporter (lp_1792), and ammonium transporter (lp_0349) were down-regulated under both acidic conditions ( Supplementary Table...”
- Characterization of transcriptional response of Lactobacillus plantarum under acidic conditions provides insight into bacterial adaptation in fermentative environments.
Jung, Scientific reports 2020 - “...GMP reductase lp_3271 F9UTG4 COG0516 K00364 lp_3278 1.47 0.000514 0.002559 Amino acid transport protein lp_3278 F9UTG8 COG0531 K03294 dapA2 1.59 6.43E19 1.18E17 hydroxy-tetrahydrodipicolinate synthase lp_2685 F9URH0 COG0329 K01714 Fold change in gene expression of group exposed to acidic conditions was calculated by edgeR R package. The...”
- Characterization of transcriptional response of Lactobacillus plantarum under acidic conditions provides insight into bacterial adaptation in fermentative environments
Jung, Scientific reports 2020 - “...synthetase lp_3270 F9UTG3 COG0104 K01939 guaC 1.88 1.04E41 4.67E40 GMP reductase lp_3271 F9UTG4 COG0516 K00364 lp_3278 1.47 0.000514 0.002559 Amino acid transport protein lp_3278 F9UTG8 COG0531 K03294 dapA2 1.59 6.43E19 1.18E17 hydroxy-tetrahydrodipicolinate synthase lp_2685 F9URH0 COG0329 K01714 Fold change in gene expression of group exposed to...”
- Functional analysis of the role of CggR (central glycolytic gene regulator) in Lactobacillus plantarum by transcriptome analysis
Rud, Microbial biotechnology 2011 - “...2.2 lp_2780 pts20A Cellobiose PTS, EIIA 2.9 0.6 0.6 lp_3008 pts23A Cellobiose PTS, EIIA 2.1 lp_3278 Amino acid transport protein 2.1 lp_3279 kup2 Potassium uptake protein 0.6 0.5 lp_3303 Multidrug transport protein 0.6 lp_3540 Transport protein 6.5 a 0.6 a lp_3541 pts34B PTS, EIIB 6.5 lp_3547...”
- Thioredoxin reductase is a key factor in the oxidative stress response of Lactobacillus plantarum WCFS1
Serrano, Microbial cell factories 2007 - “...catalytic subunit lp_0761 23,5 trxB1 thioredoxin reductase (NADPH) lp_1230 1,6 transcription regulator Regulatory function (4%) lp_3278 1,8 amino acid transport protein Transport and binding proteins (11%) lp_1087 1,8 cation transport protein lp_2992 2,6 mntH2 manganese transport protein antilp_3469 1,6 lp_RNA02 2,6 plasmids (15%) lp_p2_01 3,1 lp_p2_02...”
XF2208 cationic amino acid transporter from Xylella fastidiosa 9a5c
35% identity, 62% coverage
ACSP50_2706 amino acid permease from Actinoplanes sp. SE50/110
34% identity, 62% coverage
- A maltose-regulated large genomic region is activated by the transcriptional regulator MalT in Actinoplanes sp. SE50/110
Droste, Applied microbiology and biotechnology 2020 - “...Class II glutamine amidotransferase Amino acid metabolism ACSP50_6409 ACSP50_3920 Amino acid permease Amino acid metabolism ACSP50_2706 ; ACSP50_3876 ACSP50_3921 Arginine deiminase Arginine biosynthesis ACSP50_8316 ACSP50_3922 Ornithine carbamoyltransferase Arginine biosynthesis ACSP50_4060 ACSP50_3923 Carbamate kinase Arginine biosynthesis ACSP50_6398 ACSP50_3924 Cyclic nucleotidebinding protein (phosphodiesterase) Put. serine/threonine biosynthesis ACSP50_3944 Beta-Ala-His...”
XAC4354 amino acid transporter from Xanthomonas axonopodis pv. citri str. 306
35% identity, 64% coverage
- The citrus plant pathogen Xanthomonas citri has a dual polyamine-binding protein
Cremonesi, Biochemistry and biophysics reports 2021 - “...(PuuA/PuuP), an amino acid transporter (H + ) symporter, the proteins XAC3863/3864, XAC1841/1842 (YhdG) and XAC4354 (YhdG) forming three distinct cationic amino acid/polyamine antiporters, and the proteins XAC0856 to XAC0860 ( Fig. 2 ). The latter was previously described as the components of an oligopeptide ABC...”
CAAT8_ARATH / Q9SHH0 Cationic amino acid transporter 8, vacuolar from Arabidopsis thaliana (Mouse-ear cress) (see paper)
TC 2.A.3.3.11 / Q9SHH0 Cationic amino acid transporter 8, vacuolar from Arabidopsis thaliana (see 4 papers)
AT1G17120 CAT8 (CATIONIC AMINO ACID TRANSPORTER 8); basic amino acid transmembrane transporter/ cationic amino acid transmembrane transporter from Arabidopsis thaliana
26% identity, 90% coverage
- function: Permease involved in the transport of the cationic neutral or acidic amino acids.
- substrates: Amino acids
- Arabidopsis thaliana resistance to fusarium oxysporum 2 implicates tyrosine-sulfated peptide signaling in susceptibility and resistance to root infection
Shen, PLoS genetics 2013 - “...genes AT1G17070, AT1G17080 and AT1G17090; Kpn1.3 includes nucleotides 5846018 to 5854394 and genes AT1G17110 and AT1G17120; Xba1.2 includes nucleotides 5843587 to 5855420 and genes AT1G17100, AT1G17110 and AT1G17120; Pac1.2includes nucleotides 5850646 to 5866025 and genes AT1G17120, AT1G17130, AT1G17140, AT1G17145 and AT1G17147; Pac1.1 includes nucleotides 5866025 to...”
- The AAP gene family for amino acid permeases contributes to development of the cyst nematode Heterodera schachtii in roots of Arabidopsis
Elashry, Plant physiology and biochemistry : PPB 2013 - “...3.1 0.4 0.24 At5g04770 AtCAT6 5.3 5.9 0.6 0.03 At3g10600 AtCAT7 3.3 3 0.3 0.20 At1g17120 AtCAT8 6.5 5.6 0.9 a 0.00 At1g05940 AtCAT9 8.1 7 1.1 a 0.00 At5g05630 AtLAT1 3.5 3.7 0.2 0.43 At3g13620 ATLAT2 5.1 7 1.9 a 0.00 At1g31820 AtLAT3 4.6 3.9...”
- H-independent glutamine transport in plant root tips
Yang, PloS one 2010 - “...were used for Gln imaging. GFP was cloned in frame to the complete CAT8 sequence (At1g17120) either at the N- or C-terminus, to generate translational fusions. In the C-terminal fusions, the STOP codon was removed by PCR. For both constructs, the 35S promoter from caulifower mosaic...”
- A proteomics dissection of Arabidopsis thaliana vacuoles isolated from cell culture
Jaquinod, Molecular & cellular proteomics : MCP 2007 - “...Transp. NF NF At5g40670 At1g05940 At1g58030 At3g03720 At1g17120 At3g30390 At2g41190 At2g39130 At2g40420 At3g28960 At1g70330 31,007 60,138 67,072 63,597 64,863...”
BCAP_BACSU / O07576 Branched-chain amino acid permease BcaP; BCAA permease from Bacillus subtilis (strain 168) (see 4 papers)
BSU09460 branched-chain amino acid transporter from Bacillus subtilis subsp. subtilis str. 168
36% identity, 63% coverage
- function: Branched-chain amino acid transport system which is involved in the uptake of isoleucine, valine and probably leucine (PubMed:25645558). Can also transport threonine, and is active as a minor serine permease (PubMed:25645558, PubMed:32743959). May be an amino acid permease of rather broad specificity, because several amino acids, albeit at 100-fold excess, are able to prevent isoleucine uptake (PubMed:25645558). Probably does not transport methionine (PubMed:25645558). Together with BraB and BrnQ, plays an important role in the activation of CodY, a branched-chain amino acid-responsive transcriptional regulator that controls the expression of several dozen transcription units in B.subtilis (PubMed:25645558).
disruption phenotype: Mutant is still able to take up isoleucine, leucine and valine (PubMed:25645558). Deletion of the gene confers a weak resistance to growth inhibition by serine (PubMed:32743959). The deletion of the three permease-encoding genes aimA (ybeC), ybxG and bcaP results in an unprecedented resistance to serine up to 100 mM (PubMed:32743959). - The Blueprint of a Minimal Cell: MiniBacillus
Reuß, Microbiology and molecular biology reviews : MMBR 2016 - “...coli BSU39390 No BSU09130 No Yes BSU36900 Yes Yes BSU09460 No BSU33330 No Yes Yes Yes 3.6.3.14 3.6.3.14 Yes S protein of tryptophan ECF transporter Methionine...”
lp_1120 amino acid transport protein from Lactobacillus plantarum WCFS1
33% identity, 65% coverage
J3U91_01734 APC family permease from Oenococcus oeni
30% identity, 66% coverage
XF0408 amino acid transporter from Xylella fastidiosa 9a5c
34% identity, 65% coverage
J3U91_00916 amino acid permease from Oenococcus oeni
33% identity, 64% coverage
ACSP50_3876 amino acid permease from Actinoplanes sp. SE50/110
34% identity, 62% coverage
DQN92_RS09665 amino acid permease from Stenotrophomonas maltophilia
33% identity, 63% coverage
- Establishment and evaluation of a rapid method for the detection of bacterial pneumonia in hospitalized patients via multiplex PCR-capillary electrophoresis (MPCE)
Wang, Microbiology spectrum 2024 - “...taaAGGAATTTCTGTACGTTGGC 183 150 taaCACAGCCCTGATTGTAGGAG 150 SA SAOUHSC_01837 NC_007795.1 1,742,6921,742,898 cCGTCTTTAAATGCATTTCCTGTAGAT 210 150 gtGACCAACATAAGCAACAGGTAATA 150 SM DQN92_RS09665 NZ_LS483377.1 3,870,7493,870,974 ttcATCCTCAACATCGTCGAGTG 232 150 gttGGTACACGATCGACAGCATC 150 LP wipC NZ_CP015941.1 2,454,3372,454,559 ctaatCGCCAATCGATTTAGGAATAATCT 233 200 gtattTCACGATTCCACAATATTTGCT 200 ECO oxc NC_002695.2 3,218,8223,219,064 tctcAGAACCAGGATATTTATTTAGTTAATGA 250 150 gttGCAGGTTATATCGACAAATCGTTTC 150 AB F3P16_RS05440 NZ_CP043953.1 1,159,9451,160,214 TTAAttCAAATTGGTCTGGAGCCTA...”
- “...KPHS_16050 4.5 10 4 ECO oxc 5.0 10 5 ECC sufA 2.5 10 5 SM DQN92_RS09665 5.0 10 5 PA PA1767 1.5 10 4 SA SAOUHSC_01837 2.0 10 6 MRSA mecA 4.0 10 5 SPN SPNHU17_RS05160 6.0 10 3 SPY speB 1.0 10 4 HI fucA...”
Rv2320c PROBABLE CATIONIC AMINO ACID TRANSPORT INTEGRAL MEMBRANE PROTEIN ROCE from Mycobacterium tuberculosis H37Rv
33% identity, 67% coverage
- De novo histidine biosynthesis protects Mycobacterium tuberculosis from host IFN-γ mediated histidine starvation
Dwivedy, Communications biology 2021 - “...90 . The Mtb H37Rv genome encodes for a plethora of membrane transporters such as: Rv2320c (cationic amino acids), Rv0488 (lysine), Rv2564 (glutamine), Rv1280c (oligopeptide) and Rv1979c, which are capable of transporting amino acids 91 . However, no specific histidine transport mechanism(s) has been identified in...”
- Characterization of membrane vesicles released by Mycobacterium avium in response to environment mimicking the macrophage phagosome
Chiplunkar, Future microbiology 2019 - “...processes 44 2 A0A0H3A0D0 MAV_2087 Amino acid transporter Cell wall and cell processes 48 6 Rv2320c A0A0H3A0X6 MAV_4750 GluB bacterial extracellular solute-binding protein Cell wall and cell processes 36 2 Rv0411c A0A0H3A326 MAV_4059 Monoxygenase Intermediary metabolism and respiration 95 2 A0A0H3A3W0 MAV_0467 dppD ABC transporter, ATP-binding...”
- Integration of Metabolic Modeling with Gene Co-expression Reveals Transcriptionally Programmed Reactions Explaining Robustness in Mycobacterium tuberculosis
Puniya, Scientific reports 2016 - “...(PUNP5) HXPRT (hypoxanthine phosphoribosyltransferase Hypoxanthine) ( Rv3624c ) Purine Metabolism (PUNP5) ORNt (ornithine transport) ( Rv2320c ) Sugar Metabolism ( GMAND ) ME1 (malic enzyme NAD) ( Rv2332 ) Glycolysis ( GAPD , PGK , PYK ) DHNPA (dihydroneopterin aldolase) ( Rv3607c ) Folate Metabolism (DHPS2)...”
- In-Vivo Gene Signatures of Mycobacterium tuberculosis in C3HeB/FeJ Mice
Gautam, PloS one 2015 - “...of variety of other genes that code for the proteins like putative transporters e.g. Rv0283, Rv2320c, Rv1686c etc. and membrane protein Rv1671, Rv0954, Rv0426c etc. whose expression were either upregulated or did not change during course of infection. The sigma factor sigL dependent transcription of Rv2877c...”
- Physiology of mycobacteria
Cook, Advances in microbial physiology 2009 - “...Not surprisingly, M. tuberculosis has several genes encoding putative L-arginine uptake transporters: Rv0522, Rv1979c, Rv1999c, Rv2320c and Rv3253c ( Cole et al. , 1998 ). Transport of L-arginine, but not of L-lysine and L-ornithine, was reduced by 70% in a mutant of M. bovis BCG lacking...”
- Arginine homeostasis in J774.1 macrophages in the context of Mycobacterium bovis BCG infection
Talaue, Journal of bacteriology 2006 - “...several genes encoding putative L-arginine uptake systems (Rv0522, Rv2320c, Rv3253c, Rv1999c, and Rv1979c) in M. tuberculosis and M. bovis, most likely with...”
- “...putative cationic amino acid permeases (encoded by Rv2320c, Rv1999c, and Rv3253c) that Downloaded from http://jb.asm.org/ on February 12, 2017 by University...”
- Modulation of J774.1 macrophage L-arginine metabolism by intracellular Mycobacterium bovis BCG
Peteroy-Kelly, Infection and immunity 2003 - “...RocE L-arginine transporter (annotated as Rv0522 and Rv2320c). The presence of multiple L-arginine transporters and catabolic pathways in mycobacteria suggests...”
- “...is attributed to another L-arginine permease such as Rv2320c. Comparison of intracellular L-arginine transport and metabolism between wild-type BCG and AS1 will...”
- Amino acid transport and metabolism in mycobacteria: cloning, interruption, and characterization of an L-Arginine/gamma-aminobutyric acid permease in Mycobacterium bovis BCG
Seth, Journal of bacteriology 2000 - “...transport proteins. Two homologs were identified, Rv0522 and Rv2320c. Here, Rv0522 was cloned from BCG and used to construct a strain lacking the permease...”
- “...a second rocE homolog discovered in the Sanger database (Rv2320c). Thus, as in the enterics (11, 53), L-arginine uptake is carried by more than one permease in...”
Ga0059261_1577 L-glutamine and L-histidine transporter from Sphingomonas koreensis DSMZ 15582
36% identity, 65% coverage
- mutant phenotype: Specific phenotype on glutamine; also important for histidine utilization; detrimental to fitness on some other amino acids (proline, alanine) which may indicate that it likes these amino acids
B1745_06875 APC family permease from Lactobacillus amylolyticus
30% identity, 65% coverage
- Adaptive mechanism of Lactobacillus amylolyticus L6 in soymilk environment based on metabolism of nutrients and related gene-expression profiles
Fei, Food science & nutrition 2022 - “...glnM glutamine ABC transporter permease 1.60 B1745_02545 pepX dipeptidylpeptidase 1.56 B1745_02045 dacD DalanylDalanine carboxypeptidase 1.44 B1745_06875 amino acid permease 1.44 B1745_00945 oppD peptide ABC transporter ATPbinding protein 1.43 B1745_RS07280 lysC aspartate kinase 1.41 B1745_06870 att amino acid permease 1.40 B1745_04855 atpA haloacid dehalogenase 1.40 B1745_00955 pepC...”
- “...under soymilk environment (Wang etal., 2012 ). Meanwhile, many uncharacterized amino acid permease genes (B1745_03105, B1745_06875, B1745_06870, and B1745_06860) were upregulated, while two amino acid permease genes (B1745_04680 and B1745_03815) were downregulated in the logarithmic and stationary phase. Interestingly, two genes livB and brnQ coding for...”
W5D0X5 Cationic amino acid transporter C-terminal domain-containing protein from Triticum aestivum
32% identity, 63% coverage
OTBS_1417 Cationic amino acid transporter-1 from Orientia tsutsugamushi Boryong
30% identity, 64% coverage
- Genome-based construction of the metabolic pathways of Orientia tsutsugamushi and comparative analysis within the Rickettsiales order
Min, Comparative and functional genomics 2008 - “...transporter tlc : OTBS_0312, OTBS_0313, ATP/ADP antiporter OTBS_0547, OTBS_1035, OTBS_1636 OTBS_1312, OTBS_0017? Malate atrC1 : OTBS_1417 Cationic aminio acid potE : OTBS_1403 Arginine/orinithine p34 : OTBS_1715 Cation kefB : OTBS_1539 Potassium gltP : OTBS_0443 Proton/glutamate rarD : OTBS_0203, OTBS_0407? S-adenosylmethionine proP : OTBS_0158, OTBS_0204, Proline/betaine OTBS_0844,...”
SCO5977 amino acid permease from Streptomyces coelicolor A3(2)
32% identity, 64% coverage
- A Second Gamma-Glutamylpolyamine Synthetase, GlnA2, Is Involved in Polyamine Catabolism in Streptomyces coelicolor
Krysenko, International journal of molecular sciences 2022 - “...was also tested with promoters of other genes of the polyamine utilization pathway: sco5676 , sco5977 , sco6960 . These potential targets were identified based on their localization in the genome closely to genes that are involved in the utilization of polyamines as reported by [...”
- “...regulated by EpuRII: sco5676 , coding for a putative homologue of the 4-amino-butyrate aminotransferase GabT, sco5977 encoding a putative polyamine antiporter, and sco6960 with unknown function ( Figure 8 B). The interacting promoter regions also involved those of all four regulators epuRI , epuRII , epuRIII...”
- Polyamine and Ethanolamine Metabolism in Bacteria as an Important Component of Nitrogen Assimilation for Survival and Pathogenicity
Krysenko, Medical sciences (Basel, Switzerland) 2022 - “...EMSA analysis, EpuRII revealed control of several polyamine-associated genes, including glnA3 , sco5676 , and sco5977 ( Table 1 ). Another regulator of polyamine utilization genes is the global regulator of the nitrogen metabolism GlnR. This has been demonstrated to control the transcription of the second...”
- “...SCO5676 Succinate-semialdehyde dehydrogenase gabD-like GabD (b2661) GabD (PA0265) SCO5679 Amino acids/polyamine permease PuuP (b1296) PA5510/PAO322 SCO5977 Hydrolase - - SCO6960 Amidohydrolase - - SCO6961 -glutamyl-polyamine synthetase PuuA (b1297) PauA7 (PA5508)/SpuI (PA0296) SCO6962 medsci-10-00040-t002_Table 2 Table 2 Combined list of enzymes involved in ethanolamine utilization in C....”
- Initial Metabolic Step of a Novel Ethanolamine Utilization Pathway and Its Regulation in Streptomyces coelicolor M145
Krysenko, mBio 2019 - “...coelicolor M145 allowed in silico identification of two putative ethanolamine/amino acid permease genes, SCO6014 and SCO5977 , with rather low similarity to the putative ethanolamine permease target from other Streptomycetes spp. (43% to 45%). To verify whether the expression of SCO6014 and SCO5977 might be influenced...”
- “...of ethanolamine and ammonium (control) as the sole N source. Transcriptional analysis of SCO6014 and SCO5977 revealed strong expression of these genes in the presence of ammonium, whereas no expression was observed in the presence of ethanolamine under the tested conditions (see Fig.S1 in the supplemental...”
- Gamma-Glutamylpolyamine Synthetase GlnA3 Is Involved in the First Step of Polyamine Degradation Pathway in Streptomyces coelicolor M145
Krysenko, Frontiers in microbiology 2017 - “...). In contrast, the expression of the genes encoding the putative polyamine permeases SCO5057 and SCO5977 was strongly induced in the presence of all polyamines or only putrescine, respectively ( Figure 5 ). The expression of SCO5658 (encoding predicted polyamine binding protein) was strongly induced in...”
ZMO1804 amino acid permease-associated region from Zymomonas mobilis subsp. mobilis ZM4
32% identity, 64% coverage
- Transcriptome profiling of Zymomonas mobilis under ethanol stress
He, Biotechnology for biofuels 2012 - “...monophosphate synthase TCATTATCGCTTGCCCTTCA GAGCCGAATCAGCCAGAA 101 1.1 4.9 ZMO1802 hypothetical protein TGCTTATGCAGTGTTTGG TCAGGAAGGTGTAGAGAC 94 1.1 3.5 ZMO1804 amino acid permease-associated domain-containing protein TTTATGGATTTGATACTGTC CGCTACACCAATATAGAT 119 1.4 3.71 ZZM4_0013 P2 GpU family protein GTCACATCCATAGTAGAA TTATTGTATTGTCGTCATC 106 1.7 4.3 ZZM4_0036 protein of unknown function DUF264 CCAGAATAGTGAAGAAGG ATCAAGACCTCTAAGTTG 109 1.4...”
- “...transport and metabolism showed significant expressed under ethanol stress, such as ZMO1180, ZMO2018, hutG (ZMO1395), ZMO1804, nrdD (ZMO1025), yfeJ (ZMO1855), ZMO1522, thiE (ZMO1425), folK (ZMO1647), ssuC (ZMO1262) and ZMO0546 (see Additional file 1 : Table S1). However, 3 ORFs related carbohydrate and coenzyme transport and metabolism...”
SA2396 hypothetical protein from Staphylococcus aureus subsp. aureus N315
SAUSA300_2538 amino acid permease family protein from Staphylococcus aureus subsp. aureus USA300_FPR3757
NWMN_2500 amino acid permease family protein from Staphylococcus aureus subsp. aureus str. Newman
SACOL2619 amino acid permease from Staphylococcus aureus subsp. aureus COL
29% identity, 68% coverage
- Thioridazine induces major changes in global gene expression and cell wall composition in methicillin-resistant Staphylococcus aureus USA300
Thorsing, PloS one 2013 - “...), and histidine ( hisGDCBHAFEI ) as well as amino acid/oligopeptide transporters ( oppBCDFA , SA2396 ). In rich medium, the amino acid requirements of S. aureus are met by uptake from the environment rather than de novo synthesis; consequently, genes involved in amino acid biosynthesis...”
- Transcriptional signature following inhibition of early-stage cell wall biosynthesis in Staphylococcus aureus
O'Neill, Antimicrobial agents and chemotherapy 2009 - “...(S. aureus N315d) Gene designation (S. aureus N315) SA2357 SA2396 SA2397 SA2473 SA2475 SA2476 SA2477 SA2478 SA2490 serS sirA glcA glpT rplJ rplL fruB fruA glpQ...”
- Staphylococcus aureus ClpX localizes at the division septum and impacts transcription of genes involved in cell division, T7-secretion, and SaPI5-excision
Jensen, Scientific reports 2019 - “...0,6 2,1E-03 lip triacylglycerol lipase 0,6 5,7E-03 cap1B capsular polysaccharide biosynthesis protein Cap1B 0,6 1,4E-05 SAUSA300_2538 amino acid permease family protein 0,6 8,3E-03 dapA dihydrodipicolinate synthase 0,6 3,2E-04 spxA transcriptional regulator Spx 0,6 4,9E-04 asd aspartate semialdehyde dehydrogenase 0,6 2,0E-03 SAUSA300_0277 peptidoglycan hydrolase linked to the...”
- The role of two branched-chain amino acid transporters in Staphylococcus aureus growth, membrane fatty acid composition and virulence
Kaiser, Molecular microbiology 2016 - “...abolished in a brnQ1-2-3 mutant ( Kaiser et al., 2015 ). We prioritized the gene SAUSA300_2538 to investigate since it exhibited 34% and 63% total similarity to BcaP, a BCAA transporter in Bacillus subtilis and Lactococcus lactis respectively ( den Hengst et al., 2006 ; Belitsky,...”
- “...accepting foreign DNA ( Kreiswirth et al., 1983 ) bcaP USA300 bcaP N; Em R (SAUSA300_2538) ( Fey et al., 2013 ) brnQ1 USA300 brnQ1 ( Kaiser et al., 2015 ) brnQ1-bcaP USA300 brnQ1 bcaP N; Em R This study brnQ1-2-3 USA300 brnQ1 brnQ2 brnQ3 Tc;...”
- Cigarette Smoke Extract-Exposed Methicillin-Resistant Staphylococcus aureus Regulates Leukocyte Function for Pulmonary Persistence
Kulkarni, American journal of respiratory cell and molecular biology 2016 - “...SAUSA300_0085 SAUSA300_0347 SAUSA300_0389 SAUSA300_1811 SAUSA300_2538 SAUSA300_0432 SAUSA300_0011 SAUSA300_1055 SAUSA300_0577 SAUSA300_0433 Log2 (Fold Change)...”
- Differential gene expression in Staphylococcus aureus exposed to Orange II and Sudan III azo dyes
Pan, Journal of industrial microbiology & biotechnology 2015 - “...Cytoplasmic 2.06 SAUSA300_2385 SAUSA300_1231 SAUSA300_0864 SAUSA300_2538 SAUSA300_1808 SAUSA300_1916 SAUSA300_0914 SAUSA300_2006 ilvD EG Amino acid permease...”
- “...An amino acid permease family protein is encoded by SAUSA300_2538, which 13 754 shares 64.58 % amino acid sequence identity with BcaP in Lactococcus lactis...”
- Comparative Transcriptome Analysis Reveals Differentially Expressed Genes Related to Antimicrobial Properties of Lysostaphin in Staphylococcus aureus
Yan, Antibiotics (Basel, Switzerland) 2022 - “...region between the NWMN_0810 and NWMN_0811 genes; 2 were in the intergenic region between the NWMN_2500 and ldh genes; 2 of the InDels were in the intergenic region between the citZ and aapA genes; 2 of them were in the region between dnaA and rpmH ....”
- “...(between citZ and aapA ) RNA-seq mutant contigs 2,744,980 G 1 Deletion Intergenic region (between NWMN_2500 and Ldh ) DNAseq mutant contigs 2,744,980 G 1 Deletion Intergenic region (between NWMN_2500 and Ldh ) DNAseq mutant reads 2,878,891 CTTTTA T CTTTTATCGATTT TAT 9 Insertion Intergenic region (between...”
- CodY in Staphylococcus aureus: a regulatory link between metabolism and virulence gene expression
Pohl, Journal of bacteriology 2009 - “...NWMN_1961 NWMN_1962 NWMN_1963 NWMN_1964 NWMN_1965 NWMN_1966 NWMN_2347 NWMN_2500 NWMN_2501 NWMN_2571 NWMN_2572 Description CodY IN S. AUREUS VOL. 191, 2009 2961...”
- In vitro and in vivo models of Staphylococcus aureus endophthalmitis implicate specific nutrients in ocular infection
Sadaka, PloS one 2014 - “...protein 20.0 (1.2) 7.7 (2.8) 10.2 (1.5) ig_SACOL2585-4 Intergenic region downstream of SACOL2585 6.1 (1.1) SACOL2619 Amino acid permease 19.0 (1.2) 6.6 (2.9) 9.2 (1.7) SACOL2620 4-aminobutyrate aminotransferase 29.3 (1.3) 9.0 (3.6) 16.0 (1.5) ig_SACOL2620-1 Intergenic region upstream of SACOL2620 34.3 (1.3) 7.9 (3.4) 20.4 (2.1)...”
- Changes in the Staphylococcus aureus transcriptome during early adaptation to the lung
Chaffin, PloS one 2012 - “...compared to stationary phase cells. Significantly increased in vivo were SACOL1018, a sodium:alanine symporter, and SACOL2619 and SACOL0630, two cation/H + :amino acid symporters of unknown specificity. Several operons coding for branched-chain amino acid (BCAA) transport and responsible for transport of leucine, isoleucine and valine were...”
- A new oxidative sensing and regulation pathway mediated by the MgrA homologue SarZ in Staphylococcus aureus
Chen, Molecular microbiology 2009 - “...+ Conserved hypothetical protein SACOL2579 3.6 Phytone dehydrogenase SACOL2585 4.0 -2.0 pfoS/R like regulatory protein SACOL2619 3.1 -2.4 Amino acid permiase SACOL2704 3.0 ATP phosphoribosyltransferase reguratory subunit SAS0383 2.2 Exotoxin SAV0894 2.2 Mu50B-like protein SACOL0212 2.1 3-hydroxyacyl-CoA dehydrogenase a The entire microarray data were deposited to...”
DA471_RS05980, RSAU_002444 APC family permease from Staphylococcus aureus
28% identity, 68% coverage
SAOUHSC_02923 hypothetical protein from Staphylococcus aureus subsp. aureus NCTC 8325
28% identity, 68% coverage
lhv_1375 amino acid transporter from Lactobacillus helveticus DPC 4571
30% identity, 64% coverage
- Genome sequence and analysis of Lactobacillus helveticus
Cremonesi, Frontiers in microbiology 2012 - “...functional oligopeptide transporter lhv_2931 that is probably fulfilling the peptide transport role, whereas lhv_1028 and lhv_1375 act as amino acid transporters ( Callanan et al., 2008 ). L. helveticus has additional genes for fatty acid biosynthesis and specific amino acid metabolism, but notably fewer cell-surface proteins...”
MSMEG_1412 amino acid permease from Mycobacterium smegmatis str. MC2 155
31% identity, 66% coverage
SERP2158 amino acid permease family protein from Staphylococcus epidermidis RP62A
29% identity, 66% coverage
- Toxin Mediates Sepsis Caused by Methicillin-Resistant Staphylococcus epidermidis
Qin, PLoS pathogens 2017 - “...hypothetical protein -5.27 -11.93 2.26 - SERP1478 GntR family transcriptional regulator -4.32 -11.37 2.63 - SERP2158 amino acid permease -3.75 -3.27 -1.14 - SERP0944 ThiJ/PfpI family protein -3.71 -1.71 -2.16 trpG SERP0938 anthranilate synthase component II -3.65 -1.87 -1.96 - SERP1475 ABC transporter ATP-binding protein -3.46...”
SE2147 amino acid transporter from Staphylococcus epidermidis ATCC 12228
29% identity, 66% coverage
TC 2.A.3.3.23 / S6EX81 Branched chain amino acid (Leucine/isoleucine/valine) uptake transporter of 469 aas and 12 TMSs, BcaP or CitA from Lactococcus lactis subsp. lactis A12
28% identity, 65% coverage
- substrates: Isoleucine, Leucine, Valine
Smp_176930 putative cationic amino acid transporter from Schistosoma mansoni
27% identity, 65% coverage
MAV_2087 amino acid transporter from Mycobacterium avium 104
34% identity, 62% coverage
BCAP_LACLM / A2RHI9 Branched-chain amino acid permease BcaP; BCAA permease; BCAA transporter from Lactococcus lactis subsp. cremoris (strain MG1363) (see 2 papers)
llmg_0118 putative amino-acid transporter from Lactococcus lactis subsp. cremoris MG1363
28% identity, 65% coverage
- function: Branched-chain amino acid transport system that specifically transports branched-chain amino acids (BCAAs) (isoleucine, leucine and valine) and, to a lesser extent, methionine (PubMed:16621821). Important for CodY-mediated regulation, and required for optimal growth in media containing free amino acids as the only amino acid source (PubMed:16621821).
disruption phenotype: Deletion mutant shows a strongly reduced uptake activity of BCAAs and methionine (PubMed:16621821). Deletion of the gene results in the loss of most of the BCAA uptake activity of L.lactis, and deletion of this gene together with a second BCAA permease, encoded by brnQ, further reduced the viability of the strain (PubMed:16621821). - Transcriptional response of Lactococcus lactis during bacterial emulsification
Tarazanova, PloS one 2019 - “...1.4e-13 llmg_pseudo_43 leuA 2-Isopropylmalate synthase 14.9 3.2e-9 llmg_1284 leuC isopropylmalate isomerase large subunit 13 2.4e-12 llmg_0118 ctrA branched chain amino-acid transporter (BcaP) 7.5 2.4e-6 llmg_pseudo_64 oppF2 oligopeptide transport ATP-binding protein 5.7 1.1e-6 llmg_pseudo_65 oppD2 oligopeptide transport ATP-binding protein 7.5 6.6e-7 llmg_2024 oppA2 oligopeptide-binding protein oppA2 precursor...”
- Efficient overproduction of membrane proteins in Lactococcus lactis requires the cell envelope stress sensor/regulator couple CesSR
Pinto, PloS one 2011 - “...ones. Results Functional overproduction of BcaP, BcaP-H6 and BcaP-GFP-H6 in Lactococcus lactis L. lactis BcaP (Llmg_0118) is an approximately 50-kDa integral membrane protein. The protein, previously branded as CtrA, was recently renamed due to a better characterization of its function: it is involved in the internalization...”
- High-throughput identification and validation of in situ-expressed genes of Lactococcus lactis
Bachmann, Applied and environmental microbiology 2008 - “...ofb: Open reading framea Gene cysD relA llmg_0118 llmg_0138 llmg_0198 llmg_0226 llmg_0332 llmg_0335 llmg_0390 llmg_0447 llmg_0497 bcaP argG llmg_0565 llmg_0645...”
C9ZRE0 Cationic amino acid transporter, putative from Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)
29% identity, 64% coverage
- Immunoinformatic design of a putative multi-epitope vaccine candidate against Trypanosoma brucei gambiense
Danazumi, Computational and structural biotechnology journal 2022 - “...C9ZL71 RGAGRNLFERPAHAFERAETYLLDAVQQRMHEPLY YLLDAVQQRMHEPL C9ZZ34 PSMDENNPEIQSTL SMDENNPEI D0A1S7 AQQRRAYINFDLVPTVNS AYINFDLVPTV D0A1Y1 TDDDSFFSSGSAVLEEDTRRLQNDPLRG DDSFFSSGSAVLEED C9ZXR1 MVSMGTEIAEEDIEN MVSMGTEIAEEDIEN C9ZRE0 KRFSFVLPQPLRKSPIDV KRFSFVLPQPLRKSP D0A7R4 SMGTGSGNTIEQYFRDHNMEYTQE GNTIEQYFRDHNMEY C9ZMP2 QNFQTCFYPDGDTFLVGDRGIRLSGG GDTFLVGDRGIRLSG D0A939 LFPSLAALANVGSVSAASAEAQGPGMDGGT ANVGSVSAASAEAQG C9ZUV6 GAAAGALLPGSTEDEAQRRR GAAAGALLPGSTEDE C9ZJU1 QSSPRAATASPSTCVWQCRQDYLQ QSSPRAATASPSTCV C9ZN41 RSYLSANPGVTVFMARITSTTTTWMGG TVFMARITSTTTTWM C9ZUC9 SDRLRRDPACATNNDGAAAGPTSSAGGGELQ NDGAAAGPTSSAGGG D0AAR0 HETHGRGGTEAQTVGGGAGFPMRSTPSG D0A513 YLSHPFLGVPMKDEEK YLSHPFLGV C9ZN46 VAVLDDNATLVGRLPN...”
OEOE_RS01865 APC family permease from Oenococcus oeni PSU-1
32% identity, 64% coverage
A9497_02760, AKL23_06320 amino acid permease from Streptococcus thermophilus
29% identity, 67% coverage
- Technological and Genomic Analysis of Roles of the Cell-Envelope Protease PrtS in Yoghurt Starter Development
Tian, International journal of molecular sciences 2018 - “...ABC transporter substrate-binding protein A9497_03375 A9497_03785 A9497_07595 AKL23_RS07395 AKL23_RS01465 AKL23_RS01490 Amino acid A9497_08630 AKL23_RS02545 Transporter A9497_02760 A9497_03620 A9497_09055 AKL23_RS02000 AKL23_RS02915 AKL23_06320 Permease Branched-chain amino acid A9497_00490 A9497_01930 A9497_07910 A9497_07915 AKL23_RS01775 AKL23_RS01780 AKL23_RS05525 AKL23_RS08285 ABC transporter permease A9497_04685 A9497_04690 AKL23_RS08280 AKL23_RS08285 Permease A9497_07905 AKL23_RS01770 ABC transporter substrate-binding...”
- “...A9497_03785 A9497_07595 AKL23_RS07395 AKL23_RS01465 AKL23_RS01490 Amino acid A9497_08630 AKL23_RS02545 Transporter A9497_02760 A9497_03620 A9497_09055 AKL23_RS02000 AKL23_RS02915 AKL23_06320 Permease Branched-chain amino acid A9497_00490 A9497_01930 A9497_07910 A9497_07915 AKL23_RS01775 AKL23_RS01780 AKL23_RS05525 AKL23_RS08285 ABC transporter permease A9497_04685 A9497_04690 AKL23_RS08280 AKL23_RS08285 Permease A9497_07905 AKL23_RS01770 ABC transporter substrate-binding protein Glutamine A9497_01790 A9497_06995 A9497_00730...”
SP_1001 amino acid permease family protein from Streptococcus pneumoniae TIGR4
32% identity, 66% coverage
SPRG_01427 hypothetical protein from Saprolegnia parasitica CBS 223.65
27% identity, 65% coverage
SCO0938 amino acid transporter protein from Streptomyces coelicolor A3(2)
33% identity, 65% coverage
- Characterization of DNA Binding Sites of RokB, a ROK-Family Regulator from Streptomyces coelicolor Reveals the RokB Regulon
Bekiesch, PloS one 2016 - “...binding in SPR spectroscopy experiments. For two fragments upstream of sco6108 (Psco6108-BS) and upstream of sco0938 (Psco0938-BS) interactions with RokB were detectable ( Fig 5 ), although weaker than for the previously identified binding sites. Psco6108-BS is a 30 bp sequence ( 5-G AA G AA...”
- “...GTC A CG-3 ) and is positioned at -78 bp from the start codon of sco0938 . The four genomic binding sites were again used to generate a new matrix and to perform a genome wide search for further binding sites with the program PREDetector. Six...”
SM12261_0999 APC family permease from Streptococcus mitis NCTC 12261
32% identity, 66% coverage
SPD_0887 amino acid permease family protein from Streptococcus pneumoniae D39
33% identity, 66% coverage
- Proteomic Adaptation of Streptococcus pneumoniae to the Antimicrobial Peptide Human Beta Defensin 3 (hBD3) in Comparison to Other Cell Surface Stresses
Mücke, Microorganisms 2020 - “...by hBD3, LL-37 stress caused a significant increase in BlpS, the transporters SPD_0076, SPD_0684, and SPD_0887, and the cell surface modification proteins TacF (SPD_1128), LicD1 (SPD_1129), and DltD (SPD_2002). The changes in cell surface modification proteins are thought to decrease the negative surface charge of pneumococci...”
- The Small Molecule DAM Inhibitor, Pyrimidinedione, Disrupts Streptococcus pneumoniae Biofilm Growth In Vitro
Yadav, PloS one 2015 - “...family protein transporter activity transmembrane transport -4.2 (0.03) SPD_1170 oligopeptide ABC transporter activity -2.0 (0.04) SPD_0887 amino acid permease family protein amino acid transmembrane transporter activity -1.4 (0.05) SPD_1425 transporter, major facilitator family protein transporter activity transmembrane transport -4.2 (0.03) SPD_1409 sugar ABC transporter, ATP-binding protein...”
- Regulation of arginine acquisition and virulence gene expression in the human pathogen Streptococcus pneumoniae by transcription regulators ArgR1 and AhrC
Kloosterman, The Journal of biological chemistry 2011 - “...spd_0611 spd_0719 spd_0720 spd_0721 spd_0781 spd_0852 spd_0887 spd_0888 spd_0889 spd_1063 spd_1225 spd_1226 spd_1356 spd_1357 spd_1515 spd_1516 spd_1517...”
LBA1292 aa transporter from Lactobacillus acidophilus NCFM
30% identity, 64% coverage
SPy0016 putative amino acid permease from Streptococcus pyogenes M1 GAS
29% identity, 65% coverage
RT0297 AtrC1-like cationic amino acid transporter protein from Rickettsia typhi str. wilmington
29% identity, 64% coverage
SpyM3_0013 putative amino acid permease from Streptococcus pyogenes MGAS315
29% identity, 65% coverage
O28661 Cationic amino acid transporter (Cat-1) from Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)
27% identity, 55% coverage
lhv_1028 amino acid transporter from Lactobacillus helveticus DPC 4571
34% identity, 30% coverage
- Genome sequence and analysis of Lactobacillus helveticus
Cremonesi, Frontiers in microbiology 2012 - “...is a functional oligopeptide transporter lhv_2931 that is probably fulfilling the peptide transport role, whereas lhv_1028 and lhv_1375 act as amino acid transporters ( Callanan et al., 2008 ). L. helveticus has additional genes for fatty acid biosynthesis and specific amino acid metabolism, but notably fewer...”
LBA0943 cationic amino acid transporter from Lactobacillus acidophilus NCFM
34% identity, 30% coverage
lp_1722 APC family permease from Lactiplantibacillus plantarum WCFS1
F9UP80 4-aminobutanoate transport protein from Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
lp_1722 amino acid transport protein from Lactobacillus plantarum WCFS1
28% identity, 64% coverage
- Inorganic phosphate modifies stationary phase fitness and metabolic pathways in Lactiplantibacillus paraplantarum CRL 1905
Araoz, Frontiers in microbiology 2024 - “...Functional category a Gene Accession number b Description Fold change Amino acid transport and metabolism lp_1722 F9UP80 4-aminobutyrate aminotransferase * gdh F9UMW9 Glutamate dehydrogenase 1.6 Carbohydrate transport and metabolism xfp Q88S87 Phosphoketolase 2 2.6 rpiA Q88YY5 Ribose-5-phosphate isomerase 1.9 lp_3545 F9UUK7 D-arabitol-phosphate dehydrogenase 3.9 galM3 F9UUF3...”
- Inorganic phosphate modifies stationary phase fitness and metabolic pathways in Lactiplantibacillus paraplantarum CRL 1905
Araoz, Frontiers in microbiology 2024 - “...category a Gene Accession number b Description Fold change Amino acid transport and metabolism lp_1722 F9UP80 4-aminobutyrate aminotransferase * gdh F9UMW9 Glutamate dehydrogenase 1.6 Carbohydrate transport and metabolism xfp Q88S87 Phosphoketolase 2 2.6 rpiA Q88YY5 Ribose-5-phosphate isomerase 1.9 lp_3545 F9UUK7 D-arabitol-phosphate dehydrogenase 3.9 galM3 F9UUF3 Aldose...”
- Transcriptomic Evidence of Molecular Mechanisms Underlying the Response of Lactobacillus Plantarum WCFS1 to Hydroxytyrosol
Reverón, Antioxidants (Basel, Switzerland) 2020 - “...the downregulation of several transporters for these substances. These included the lp_3324 (glycine betaine/carnitine/choline transporter), lp_1722 (GABA transporter) and lp_0265 (trehalose PTS transport system) genes, which is coincident with the response of L. plantarum to p-coumaric acid [ 7 ], a phenolic compound that turns leaky...”
- Transcriptional Reprogramming at Genome-Scale of Lactobacillus plantarum WCFS1 in Response to Olive Oil Challenge
Esteban-Torres, Frontiers in microbiology 2017 - “...(trehalose-6-phosphate hydrolase), lp_0264 and lp_0265 (PTS system trehalose-specific transporter subunits IIBC), the GABA transporter ( lp_1722 ) and two aquaporins ( lp_0372 and lp_3436 ), which were all downregulated. This profile indicates that these compatible solutes are not required to protect L. plantarum from EVOO. Respiration...”
lpp0357 hypothetical protein from Legionella pneumophila str. Paris
25% identity, 59% coverage
Htur_0566 amino acid permease-associated region from Haloterrigena turkmenica DSM 5511
25% identity, 55% coverage
lpg0281 amino acid transporter from Legionella pneumophila subsp. pneumophila str. Philadelphia 1
25% identity, 59% coverage
- Mammalian Solute Carrier (SLC)-like transporters of Legionella pneumophila
Best, Scientific reports 2018 - “...SLC7a5 (0.954) LstE (Lpg0228) 25% 42% Cationic amino acids (arginine, lysine, ornithine) SLC7a1 (0.848) LstF (Lpg0281) 25% 53% Cationic amino acids (arginine, lysine, ornithine) SLC7a1 (0.985) LstG (Lpg0970) 25% 44% Cationic amino acids (arginine, lysine, ornithine) SLC7a4 (0.855) LstH (Lpg1691) 27% 45% Cationic amino acids (arginine,...”
SAM23877_5660 APC family permease from Streptomyces ambofaciens ATCC 23877
27% identity, 67% coverage
Q7NI34 Gll2350 protein from Gloeobacter violaceus (strain ATCC 29082 / PCC 7421)
26% identity, 63% coverage
HVO_2500 cationic amino acid transporter from Haloferax volcanii DS2
25% identity, 57% coverage
EB836_13825 APC family permease from Brevibacterium sp. S111
28% identity, 61% coverage
- Brevibacterium from Austrian hard cheese harbor a putative histamine catabolism pathway and a plasmid for adaptation to the cheese environment
Anast, Scientific reports 2019 - “...identity (%), [coverage %], NCBI GenBank locus_tag HinA permease (AWA45220) 50 [98], EB834_11790 51 [98], EB836_13825 50 [98], EB835_06785 HinD EC 1.2.1.3 aldehyde dehydrogenase (AWA45224) 50 [98], EB834_10860 50 [99], EB836_11485 50 [99], EB835_13590 HinF EC 1.14.13.5 FAD-monooxygenase (AWA45229) 63 [92], EB834_10890 60 [94], EB836_11515 61...”
XP_039301531 cationic amino acid transporter 3-like from Nilaparvata lugens
49% identity, 16% coverage
Q7UY13 Amino acid transporter from Rhodopirellula baltica (strain DSM 10527 / NCIMB 13988 / SH1)
27% identity, 61% coverage
Msed_0408 amino acid permease-associated region from Metallosphaera sedula DSM 5348
25% identity, 63% coverage
MSMEG_6727 amino acid permease-associated region from Mycobacterium smegmatis str. MC2 155
27% identity, 62% coverage
BAT1_RABIT / Q9N1R6 b(0,+)-type amino acid transporter 1; b(0,+)AT; 4F2-LC6; Glycoprotein-associated amino acid transporter b0,+AT1; Solute carrier family 7 member 9 from Oryctolagus cuniculus (Rabbit) (see paper)
23% identity, 63% coverage
- function: Mediates the electrogenic exchange between cationic amino acids and neutral amino acids, with a stoichiometry of 1:1 (By similarity). Has system b(0,+)-like activity with high affinity for extracellular cationic amino acids and L-cystine and lower affinity for intracellular neutral amino acids (By similarity). Substrate exchange is driven by high concentration of intracellular neutral amino acids and the intracellular reduction of L-cystine to L-cysteine (By similarity). Required for reabsorption of L-cystine and dibasic amino acids across the brush border membrane in renal proximal tubules (By similarity).
catalytic activity: L-leucine(out) + L-arginine(in) = L-leucine(in) + L- arginine(out) (RHEA:71059)
catalytic activity: L-histidine(out) + L-arginine(in) = L-histidine(in) + L- arginine(out) (RHEA:71063)
catalytic activity: L-phenylalanine(out) + L-arginine(in) = L-phenylalanine(in) + L-arginine(out) (RHEA:71067)
catalytic activity: L-cysteine(out) + L-arginine(in) = L-cysteine(in) + L- arginine(out) (RHEA:71071)
catalytic activity: L-cystine(out) + L-arginine(in) = L-cystine(in) + L- arginine(out) (RHEA:71075)
catalytic activity: L-lysine(out) + L-arginine(in) = L-lysine(in) + L- arginine(out) (RHEA:70827)
subunit: Disulfide-linked heterodimer composed of the catalytic light chain subunit SLC7A9 and the heavy chain subunit. The heterodimer is the minimal functional unit. Assembles in heterotetramers (dimers of heterodimers) and higher order oligomers (By similarity). Interacts with CAV1 (By similarity).
EB835_06785 APC family permease from Brevibacterium sp. S22
27% identity, 62% coverage
- Brevibacterium from Austrian hard cheese harbor a putative histamine catabolism pathway and a plasmid for adaptation to the cheese environment
Anast, Scientific reports 2019 - “...%], NCBI GenBank locus_tag HinA permease (AWA45220) 50 [98], EB834_11790 51 [98], EB836_13825 50 [98], EB835_06785 HinD EC 1.2.1.3 aldehyde dehydrogenase (AWA45224) 50 [98], EB834_10860 50 [99], EB836_11485 50 [99], EB835_13590 HinF EC 1.14.13.5 FAD-monooxygenase (AWA45229) 63 [92], EB834_10890 60 [94], EB836_11515 61 [92], EB835_13560 HinG...”
EB834_11790 APC family permease from Brevibacterium aurantiacum
28% identity, 61% coverage
- Brevibacterium from Austrian hard cheese harbor a putative histamine catabolism pathway and a plasmid for adaptation to the cheese environment
Anast, Scientific reports 2019 - “...S22 Amino acid identity (%), [coverage %], NCBI GenBank locus_tag HinA permease (AWA45220) 50 [98], EB834_11790 51 [98], EB836_13825 50 [98], EB835_06785 HinD EC 1.2.1.3 aldehyde dehydrogenase (AWA45224) 50 [98], EB834_10860 50 [99], EB836_11485 50 [99], EB835_13590 HinF EC 1.14.13.5 FAD-monooxygenase (AWA45229) 63 [92], EB834_10890 60...”
F1QGJ2 B(0,+)-type amino acid transporter 1 from Danio rerio
24% identity, 60% coverage
CBO0389 amino acid permease from Clostridium botulinum A str. ATCC 3502
24% identity, 64% coverage
- Transcriptomic analysis of (group I) Clostridium botulinum ATCC 3502 cold shock response
Dahlsten, PloS one 2014 - “...and components of a putative ABC transporter was observed, as well as 16-fold induction of cbo0389 encoding a putative amino acid permease. The Effects of Prolonged Cold Exposure on the Transcriptome of C. botulinum ATCC 3502 The transcription of a large number of genes was markedly...”
- “...were both down-regulated. Another strongly up-regulated gene (180-fold) 5 h after the cold shock was cbo0389 putatively encoding an amino acid permease. Additionally, the transcription of another putatively amino acid permease-encoding cbo0343 was 4.5-fold induced. Regulatory functions In total, 30 genes with predicted regulatory roles were...”
CD630_01650 APC family permease from Clostridioides difficile 630
CD0165 putative amino acid transporter from Clostridium difficile 630
23% identity, 60% coverage
SE2021 amino acid transporter from Staphylococcus epidermidis ATCC 12228
SERP2034 amino acid permease family protein from Staphylococcus epidermidis RP62A
26% identity, 60% coverage
NP_001041574 B(0,+)-type amino acid transporter 1 from Canis lupus familiaris
24% identity, 60% coverage
XP_039281097 Y+L amino acid transporter 2-like isoform X1 from Nilaparvata lugens
24% identity, 62% coverage
SSO1463 Amino acid transporter from Sulfolobus solfataricus P2
25% identity, 63% coverage
CDBI1_00900 APC family permease from Clostridioides difficile BI1
23% identity, 60% coverage
CV1138 proline-specific permease from Chromobacterium violaceum ATCC 12472
23% identity, 56% coverage
TC 2.A.3.8.29 / F1R8V8 Cationic amino acid transporter, y+LAT1 from Danio rerio
NP_001032648 Y+L amino acid transporter 1 from Danio rerio
23% identity, 60% coverage
ABA1_03000 amino acid permease from Acinetobacter baumannii
24% identity, 56% coverage
CLM70_03985 amino acid permease from Acinetobacter baumannii
24% identity, 56% coverage
PFLU3323 putative amino-acid permease membrane protein from Pseudomonas fluorescens SBW25
23% identity, 62% coverage
LBA1086 amino acid permease from Lactobacillus acidophilus NCFM
23% identity, 64% coverage
B1745_06860 APC family permease from Lactobacillus amylolyticus
24% identity, 61% coverage
- Adaptive mechanism of Lactobacillus amylolyticus L6 in soymilk environment based on metabolism of nutrients and related gene-expression profiles
Fei, Food science & nutrition 2022 - “...B1745_04550 glmS glutaminefructose6phosphate transaminase (isomerizing) 2.34 B1745_00615 adaB cysteine methyltransferase 2.00 B1745_01515 pepC aminopeptidase 1.55 B1745_06860 amino acid permease 1.54 B1745_00965 hsp20 heatshock protein Hsp20 1.52 B1745_03805 uvrC excinuclease ABC subunit C 1.45 B1745_06885 clpE ATPdependent Clp protease ATPbinding subunit 1.40 B1745_04960 clpE Clp protease ClpE...”
- “...(Wang etal., 2012 ). Meanwhile, many uncharacterized amino acid permease genes (B1745_03105, B1745_06875, B1745_06870, and B1745_06860) were upregulated, while two amino acid permease genes (B1745_04680 and B1745_03815) were downregulated in the logarithmic and stationary phase. Interestingly, two genes livB and brnQ coding for branchedchain amino acid...”
BAT1_HUMAN / P82251 b(0,+)-type amino acid transporter 1; b(0,+)AT1; Glycoprotein-associated amino acid transporter b0,+AT1; Solute carrier family 7 member 9 from Homo sapiens (Human) (see 16 papers)
TC 2.A.3.8.19 / P82251 B(0,+)-type amino acid transporter 1 (B(0,+)AT) (Glycoprotein-associated amino acid transporter b0,+AT1) (Solute carrier family 7 member 9) from Homo sapiens (see 9 papers)
XP_011524704 B(0,+)-type amino acid transporter 1 isoform X1 from Homo sapiens
22% identity, 62% coverage
- function: Associates with SLC3A1 to form a functional transporter complex that mediates the electrogenic exchange between cationic amino acids and neutral amino acids, with a stoichiometry of 1:1 (PubMed:16825196, PubMed:32494597, PubMed:32817565, PubMed:8663357). Has system b(0,+)-like activity with high affinity for extracellular cationic amino acids and L-cystine and lower affinity for intracellular neutral amino acids (PubMed:16825196, PubMed:32494597, PubMed:8663357). Substrate exchange is driven by high concentration of intracellular neutral amino acids and the intracellular reduction of L-cystine to L- cysteine (PubMed:8663357). Required for reabsorption of L-cystine and dibasic amino acids across the brush border membrane in renal proximal tubules.
catalytic activity: L-leucine(out) + L-arginine(in) = L-leucine(in) + L- arginine(out) (RHEA:71059)
catalytic activity: L-histidine(out) + L-arginine(in) = L-histidine(in) + L- arginine(out) (RHEA:71063)
catalytic activity: L-phenylalanine(out) + L-arginine(in) = L-phenylalanine(in) + L-arginine(out) (RHEA:71067)
catalytic activity: L-cysteine(out) + L-arginine(in) = L-cysteine(in) + L- arginine(out) (RHEA:71071)
catalytic activity: L-cystine(out) + L-arginine(in) = L-cystine(in) + L- arginine(out) (RHEA:71075)
catalytic activity: L-lysine(out) + L-arginine(in) = L-lysine(in) + L- arginine(out) (RHEA:70827)
subunit: Disulfide-linked heterodimer composed of the catalytic light chain subunit SLC7A9 and the heavy chain subunit SLC3A1. The heterodimer is the minimal functional unit. Assembles in heterotetramers (dimers of heterodimers) and higher order oligomers; the oligomerization is mediated by SLC3A1 likely to prevent degradation and facilitate heteromer trafficking to the plasma membrane (PubMed:16825196, PubMed:32494597, PubMed:32817565). Interacts with CAV1 (By similarity). - substrates: Amino acids
- Interpretation of SLC3A1 and SLC7A9 variants in cystinuria patients: The significance of the PM3 criterion and protein stability.
Lee, Urolithiasis 2023 - GeneRIF: Interpretation of SLC3A1 and SLC7A9 variants in cystinuria patients: The significance of the PM3 criterion and protein stability.
- Population genetics analysis of SLC3A1 and SLC7A9 revealed the etiology of cystine stone may be more than what our current genetic knowledge can explain.
Wu, Urolithiasis 2023 (PubMed)- GeneRIF: Population genetics analysis of SLC3A1 and SLC7A9 revealed the etiology of cystine stone may be more than what our current genetic knowledge can explain.
- SLC7A9 as a Potential Biomarker for Lymph Node Metastasis of Esophageal Squamous Cell Carcinoma.
Baba, Annals of surgical oncology 2022 (PubMed)- GeneRIF: SLC7A9 as a Potential Biomarker for Lymph Node Metastasis of Esophageal Squamous Cell Carcinoma.
- Clinical profile of a Polish cohort of children and young adults with cystinuria.
Tkaczyk, Renal failure 2021 - GeneRIF: Clinical profile of a Polish cohort of children and young adults with cystinuria.
- Structural basis for amino acid exchange by a human heteromeric amino acid transporter.
Wu, Proceedings of the National Academy of Sciences of the United States of America 2020 - GeneRIF: Structural basis for amino acid exchange by a human heteromeric amino acid transporter.
- In silico analysis of SLC3A1 and SLC7A9 mutations in Iranian patients with Cystinuria.
Mahdavi, Molecular biology reports 2018 (PubMed)- GeneRIF: Study shows that various computational tools were able to distinguish cystinuria-causing mutations from benign polymorphisms. Only missense mutation V142A had a benign effect on the protein structure and function of SLC7A9. The intron variant c.604+66C>G in SLC7A9 gene probably affected the splicing process.
- Clinical, Biochemical, and Genetic Findings of Cystinuria in Chinese Children.
Ma, Clinical laboratory 2018 (PubMed)- GeneRIF: A homozygous c.325G>A mutation in cationic amino cid transport proteins (SLC7A9) was identified in two patients, and six neutral and basic amino acid transporter protein (SLC3A1) mutations were found in five patients.
- A Novel Mutation in SLC7A9 Gene in Cystinuria.
Fazaeli, Iranian journal of kidney diseases 2017 (PubMed)- GeneRIF: A new variation in exon 4 of the SLC7A9 gene was identified in cystinuria patients, which was insertion of 1 adenine nucleotide between 2 cytosine nucleotides in position c.213-214insA.
- More
- Predicting hotspots for disease-causing single nucleotide variants using sequences-based coevolution, network analysis, and machine learning.
Zheng, PloS one 2024 - “...association and relative motions. 10.1371/journal.pone.0302504.g003 Fig 3 Results for amino acid transporter 1 (Uniprot id: P82251). (a) Four contact maps constructed from coevolution analysis by DeepMetaPSICOV (DMP), RaptorX (RX), SPOT-Contact (SC), and the predicted structure by AlphaFold (AF) (only those contacts with probability >0.1 are shown)....”
- They all rock: A systematic comparison of conformational movements in LeuT-fold transporters.
Licht, bioRxiv : the preprint server for biology 2024 - “...alanine X-ray 2.86 C _BasC A8UCQ5 6F2G (A) I op n/a X-ray 2.92 Hs BAT1 P82251 6LI9 (B) I op arginine cryo-EM 2.3 Ec GadC P63235 4DJK (A) I op n/a X-ray 3.097 Hs LAT2 Q9UHI5 7CMI (B) I op leucine cryo-EM 2.9 Hs xCT Q9UPY5...”
- Compendium of causative genes and their encoded proteins for common monogenic disorders.
Apgar, Protein science : a publication of the Protein Society 2022 - Identify Molecular Mechanisms of Jiangzhi Decoction on Nonalcoholic Fatty Liver Disease by Network Pharmacology Analysis and Experimental Validation.
Wang, BioMed research international 2020 - “...Nuclear receptor subfamily 1 group H member 3 19 P13716 210 ALAD Aminolevulinate dehydratase 20 P82251 11136 SLC7A9 Solute carrier family 7 member 9 21 Q8N159 162417 NAGS N-Acetylglutamate synthase 22 P21549 189 AGXT Alanine-glyoxylate and serine-pyruvate aminotransferase 23 P34896 6470 SHMT1 Serine hydroxymethyltransferase 1 24...”
- Effects of Mutations and Ligands on the Thermostability of the l-Arginine/Agmatine Antiporter AdiC and Deduced Insights into Ligand-Binding of Human l-Type Amino Acid Transporters.
Ilgü, International journal of molecular sciences 2018 - “...of the used proteins are: P60061 (AdiC), Q01650 (SCL7A5), Q92536 (SLC7A6), Q9UM01 (SLC7A7), Q9UHI5 (SLC7A8), P82251 (SLC7A9), Q9NS82 (SLC7A10), Q9UPY5 (SLC7A11), and Q8TCU3 (SLC7A13). 3.5. Homology Models and Ligand Docking We show a previously published homology model of LAT1 bound to phenylalanine, which was built based...”
- THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Transporters
Alexander, British journal of pharmacology 2017 - “...SLC7A6 SLC7A9 SLC7A10 SLC7A11 SLC7A13 HGNC, UniProt SLC7A7 , Q9UM01 SLC7A6 , Q92536 SLC7A9 , P82251 SLC7A10 , Q9NS82 SLC7A11 , Q9UPY5 SLC7A13 , Q8TCU3 Common abreviation y+LAT1 y+LAT2 b 0,+ AT Asc1 xCT Inhibitors quisqualate (pIC 50 5.3) [ 164 ] Comments CAT4 appears to...”
- The Concise Guide to PHARMACOLOGY 2015/16: Transporters
Alexander, British journal of pharmacology 2015 - “...0,+ AT HGNC, UniProt SLC7A8 , Q9UHI5 SLC7A7 , Q9UM01 SLC7A6 , Q92536 SLC7A9 , P82251 Nomenclature Asctype amino acid transporter 1 Cystine/glutamate transporter AGT1 Systematic nomenclature SLC7A10 SLC7A11 SLC7A13 Common abreviation Asc1 xCT HGNC, UniProt SLC7A10 , Q9NS82 SLC7A11 , Q9UPY5 SLC7A13 , Q8TCU3 Comments...”
- State of the human proteome in 2013 as viewed through PeptideAtlas: comparing the kidney, urine, and plasma proteomes for the biology- and disease-driven Human Proteome Project.
Farrah, Journal of proteome research 2014 - “...0 0 4 2 glomerulus UBE2Q2 Q8WVN8 Ubiquitin-conjugating enzyme E2 Q2 0 0 0 SLC7A9 P82251 B(0,+)-type amino acid transporter 1 0 0 0 CPS1 P31327 Carbamoyl-phosphate synthase [ammonia], mitochondrial 0 0 0.012 SLC22A2 O15244 Solute carrier family 22 member 2 3.1 0 0 44 2...”
- More
LH92_RS05285 amino acid permease from Acinetobacter baumannii
23% identity, 57% coverage
- Importance of twitching and surface-associated motility in the virulence of Acinetobacter baumannii
Corral, Virulence 2021 - “...with the corresponding gene cloned, Km r , Zeo r , Gm r This work LH92_RS05285 MAR002 derivative strain with LH92 _ RS05285 ::pCR-BluntII-TOPO disruption, Km r , Zeo r This work LH92_RS05285 complemented LH92_RS05285 strain carrying the pBAV1K-T5-gfp plasmid with the corresponding gene cloned, Km...”
- “...secretion system protein VgrG 2.00 S group LH92_RS00045 WP_047479431.1 ABC transporter ATP-binding protein 2.64 2.13 LH92_RS05285 WP_079267361.1 Amino acid permease 4.66 2.55 LH92_RS08005 WP_001162376.1 Phosphoglycerate mutase family protein 5.93 3.99 LH92_RS12010 WP_004840631.1 Multidrug efflux RND transporter outer membrane subunit AdeH 2.69 1.10 LH92_RS16065 WP_000521916.1 Sulfate ABC...”
ECs0116 aromatic amino acid transport protein from Escherichia coli O157:H7 str. Sakai
23% identity, 57% coverage
- Detecting non-orthology in the COGs database and other approaches grouping orthologs using genome-specific best hits
Dessimoz, Nucleic acids research 2006 - “...3: ZyifK, 4: ZproY, 5: ZcycA, 6: ZansP, 7: ZgabP), E.coli H7 (1: ECs0614, 2: ECs0116, 3: ECs4729, 4: ECs0452, 5: ECs5186, 6: ECs2057, 7: ECs3524), P.aeruginosa (2a: PA3000, 2b: PA0866, 4a: PA5097, 4b: PA0789, 7: PA0129, out: PA2079), Salmonella typhimurium LT2 (1: STM0568, 2: STM0150,...”
S0111 aromatic amino acid transport protein from Shigella flexneri 2a str. 2457T
23% identity, 57% coverage
AroR / b0112 aromatic amino acid:H+ symporter AroP from Escherichia coli K-12 substr. MG1655 (see 5 papers)
aroP / P15993 aromatic amino acid:H+ symporter AroP from Escherichia coli (strain K12) (see 6 papers)
AROP_ECOLI / P15993 Aromatic amino acid transport protein AroP; Aromatic amino acid:H(+) symporter AroP; General aromatic amino acid permease; General aromatic transport system from Escherichia coli (strain K12) (see 8 papers)
TC 2.A.3.1.3 / P15993 Aromatic amino acid:H+ symporter, AroP of 457 aas and 12 TMSs (Cosgriff and Pittard 1997). Transports phenylalanine, tyrosine and tryptophan from Escherichia coli (see 6 papers)
b0112 aromatic amino acid transporter from Escherichia coli str. K-12 substr. MG1655
23% identity, 57% coverage
- function: Permease that is involved in the active transport across the cytoplasmic membrane of all three aromatic amino acids, phenylalanine, tyrosine and tryptophan.
catalytic activity: L-phenylalanine(in) + H(+)(in) = L-phenylalanine(out) + H(+)(out) (RHEA:28923)
catalytic activity: L-tryptophan(in) + H(+)(in) = L-tryptophan(out) + H(+)(out) (RHEA:28879)
catalytic activity: L-tyrosine(in) + H(+)(in) = L-tyrosine(out) + H(+)(out) (RHEA:28875)
disruption phenotype: Mutants show reduced aromatic amino acids transport and are resistant to p-fluorophenylalanine, beta-2- thienylalanine and 5-methyltryptophan. - substrates: phenylalanine, tryptophan, tyrosine
- Extracellular loops matter - subcellular location and function of the lysine transporter Lyp1 from Saccharomyces cerevisiae
Van't, The FEBS journal 2020 - “...to Lat1, Lat2, and Xct, respectively; and for bacterial, P24207 , P37460 , P25737 , P15993 , P0AAE0 , P25527 , P77610 , P39137 , and P42087 corresponding to PheP, ProY, LysP, AroP, CycA, GabP, AnsP, RocE, and HutM, respectively. This resulted in a population of...”
- The two-component system histidine kinase EnvZ contributes to Avian pathogenic Escherichia coli pathogenicity by regulating biofilm formation and stress responses
Fu, Poultry science 2023 - “...slp Outer membrane lipoprotein 2.21 b0565 ompT Outer membrane protein 3b (a), protease VII 2.16 b0112 aroP Aromatic amino acid transport protein AroP 1.96 b3688 yidQ Outer membrane protein 1.80 FeS cluster b4291 fecA Iron complex outer membrane receptor protein, putative iron compound receptor 7.37 b1451...”
- Stationary-phase quorum-sensing signals affect autoinducer-2 and gene expression in Escherichia coli
Ren, Applied and environmental microbiology 2004 - “...b1020 2.6 2.5 2.4 2.3 2.3 2.1 2.1 aroP b0112 2 flgJ pyrE b1081 b3642 2 2 Phosphate regulon regulatory protein PhoB Nucleoside permease (nucleoside-transport...”
TC 2.A.3.8.3 / Q26594 The schistosome neutral and cationic amino acid transporter, SPRM1lc (Na+-independent), (takes up phe, arg, lys, ala, gln, his, trp and leu; functions with SPRM1hc (TC# 8.A.9.3.1) from Schistosoma mansoni (Blood fluke)
25% identity, 63% coverage
- substrates: Alanine, Arginine, Glutamine, Histidine, Leucine, lysine, phenylalanine, tryptophan
SAMSHR1132_RS12095 APC family permease from Staphylococcus argenteus
24% identity, 60% coverage
VK055_1734 amino acid permease from Klebsiella pneumoniae subsp. pneumoniae
21% identity, 62% coverage
XCT_MOUSE / Q9WTR6 Cystine/glutamate transporter; Amino acid transport system xc-; Solute carrier family 7 member 11; Subtle gray protein; xCT from Mus musculus (Mouse) (see 8 papers)
TC 2.A.3.8.5 / Q9WTR6 Cystine/glutamate antiporter, xCT (requires the 4F2hc protein (TC #8.A.9.2.1)). Functions in the generation of glutathione and plays a role in the oxidative stress response from Mus musculus (Mouse) (see 3 papers)
NP_036120 cystine/glutamate transporter from Mus musculus
23% identity, 62% coverage
- function: Heterodimer with SLC3A2, that functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane (Probable) (PubMed:10206947, PubMed:12235164, PubMed:16037214, PubMed:16144837, PubMed:17035536). Provides L-cystine for the maintenance of the redox balance between extracellular L-cystine and L- cysteine and for the maintenance of the intracellular levels of glutathione that is essential for protection of cells from oxidative stress (PubMed:16037214, PubMed:16144837, PubMed:17035536, PubMed:31396687). The transport is sodium-independent, electroneutral with a stoichiometry of 1:1, and is drove by the high intracellular concentration of L-glutamate and the intracellular reduction of L- cystine (PubMed:10206947). In addition, mediates the import of L- kynurenine leading to anti-ferroptotic signaling propagation required to maintain L-cystine and glutathione homeostasis (By similarity). Moreover, mediates N-acetyl-L-cysteine uptake into the placenta leading to subsequently down-regulation of pathways associated with oxidative stress, inflammation and apoptosis (By similarity). In vitro can also transport L-aspartate (By similarity). May participate in astrocyte and meningeal cell proliferation during development and can provide neuroprotection by promoting glutathione synthesis and delivery from non-neuronal cells such as astrocytes and meningeal cells to immature neurons (PubMed:17035536). Controls the production of pheomelanin pigment directly (PubMed:16037214).
catalytic activity: L-cystine(out) + L-glutamate(in) = L-cystine(in) + L- glutamate(out) (RHEA:70995)
catalytic activity: an L-alpha-amino acid(in) + L-kynurenine(out) = an L-alpha- amino acid(out) + L-kynurenine(in) (RHEA:71191)
catalytic activity: N-acetyl-L-cysteine(out) + L-glutamate(in) = N-acetyl-L- cysteine(in) + L-glutamate(out) (RHEA:74567)
subunit: Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc; this interaction mediates cell membrane localization.
disruption phenotype: Homozygous mice lacking SLC7A11 are healthy in appearance at the age of 6 months, develop normally and both males and females are fertile (PubMed:16144837). Mice contain approximately the double of plasma L-cystine concentration and approximately the half of glutathione concentration compare to the wild-type mice (PubMed:16144837). Subtle gray (sut) homozygous mice have reduced yellow hair pigment but the black pigment seems unaffected (PubMed:16037214). Sut mice exhibit a normal body weight but brain size is significantly reduced indicating an atrophy in certain brain tissues. Indeed, sut/sut mice exhibit pronounced enlargement of the ventricles, accompanied by thinning of the cortex and shrinkage of the striatum (PubMed:17035536). - substrates: Cystine, glutamate
- l(2)01810 is a novel type of glutamate transporter that is responsible for megamitochondrial formation
Shim, The Biochemical journal 2011 - “...(NP_004162), Dmel Eaat2 (NP_001162844), Dmel genderblind (NP_651536), Cele aat-1 (NP_501707), Drer SLC7a11-like (XP_001919426), Mmus xCT (NP_036120), Hsap xCT (NP_055146), Dmel l(2)01810 (NP_620115), Dmel VGLUT (NP_608681), Cele eat-4 (NP_499023), Drer SLC17a7 (NP_001092225), Hsap VGLUT1 (NP_064705), Rnor VGLUT1 (NP_446311), Dmel arala1 (NP_733365), Cele Q21153 (NP_497274), Drer SLC25a12 (NP_997947),...”
- Salidroside Alleviates Renal Fibrosis in SAMP8 Mice by Inhibiting Ferroptosis.
Yang, Molecules (Basel, Switzerland) 2022 - “...Potential targets ID. Uniprot ID PDB ID AlphaFord ID Gene Symbol P36970 5l71 GPX4 D4ADU2 Q9WTR6 SLC7A11 O35547 Q9QUJ7 ACSL4 P19132 5xb1 FTH1 Q99376 Q62351 TFR1 Q923U9 Q9JHI9 FPN1 molecules-27-08039-t002_Table 2 Table 2 Gene primer sequence used for qRT-PCR. GPX4 Forward primer CCGCCGAGATGAGCTGG Reverse primer GTCGATGTCCTTGGCTGAG...”
- Quantitative Proteomic Analysis of Cellular Responses to a Designed Amino Acid Feed in a Monoclonal Antibody Producing Chinese Hamster Ovary Cell Line
Torkashvand, Iranian biomedical journal 2018 - “...No. Protein name Protein ID Fold change Mus musculus homologous 1 Cystine/glutamate transporter A0A098KXA0 3.2 Q9WTR6 2 Lactoylglutathionelyase A0A061 2.4 Q9CPU0 3 Carboxylic ester hydrolase A0A061IAA7 2.3 Q64176 4 Hydroxymethylglutaryl-CoA synthase, mitochondrial G3HP76 2.3 P54869 5 Glutathione S-transferase G3IFJ6 2.2 P30115 6 Bifunctionalmethylenetetrahydrofolate dehydrogenase/cyclohydrolase A0A061HZ57 2.0...”
- Hydrogen sulfide increases glutathione biosynthesis, and glucose uptake and utilisation in C2C12 mouse myotubes.
Parsanathan, Free radical research 2018 - “...Comparison of the amino acid sequences of Slc7a11/xCT human (Q9UPY9 in the UniProtKB database), mouse (Q9WTR6), and rat (D4ADU2), and a similar comparison of sequences of Slc2a4/GLUT4 human (P14672), mouse (P14142), and rat (P19357) indicated that the localization of cysteine residues is conserved in all species....”
- “...of the same class. SWISS- MODEL workspace was used to generate models for mouse Slc7a11 (Q9WTR6) and Slc2a4 (P14142). The SWISS-MODEL template library (SMTL version 2016-11-09, PDB release 2016-11-05) was searched with Blast [ 41 ] and HHBlits [ 42 ] for evolutionarily related structures matching...”
- Nonvesicular release of glutamate by glial xCT transporters suppresses glutamate receptor clustering in vivo.
Augustin, The Journal of neuroscience : the official journal of the Society for Neuroscience 2007
SAR2540 putative amino acid permease from Staphylococcus aureus subsp. aureus MRSA252
23% identity, 62% coverage
PA14_04210 putative amino acid transporter from Pseudomonas aeruginosa UCBPP-PA14
27% identity, 55% coverage
6li9B / P82251 Heteromeric amino acid transporter b0,+at-rbat complex bound with arginine (see paper)
22% identity, 60% coverage
PP1059, PP_1059 amino acid permease from Pseudomonas putida KT2440
25% identity, 64% coverage
PA0322 probable transporter from Pseudomonas aeruginosa PAO1
27% identity, 55% coverage
SG0465 aromatic amino acid transport protein from Sodalis glossinidius str. 'morsitans'
24% identity, 60% coverage
LBA1902 amino acid permease from Lactobacillus acidophilus NCFM
24% identity, 53% coverage
TC 2.A.3.8.2 / O13020 L-type neutral amino acid transporter, ASUR4 (Na+-independent) of 507 aas and 12 TMSs. Pregabalin (PGB), a drug for the treatment of epilepsy, neuropathic pain, fibromyalgia, and generalized anxiety disorder, may be transported by L-type transporters from Xenopus laevis (African clawed frog) (see 2 papers)
25% identity, 62% coverage
SAEMRSA15_RS12955 APC family permease from Staphylococcus aureus subsp. aureus HO 5096 0412
23% identity, 60% coverage
- A functional menadione biosynthesis pathway is required for capsule production by Staphylococcus aureus
Altwiley, Microbiology (Reading, England) 2021 - “...ligase 0.00139006 SAEMRSA15_RS12840 glycerate kinase 0.00280998 SAEMRSA15_RS11120 ATP synthase subunit I 0.0030996 SAEMRSA15_RS02630 amidohydrolase 0.00366703 SAEMRSA15_RS12955 APC family permease 0.00386528 SAEMRSA15_RS13455 LrgB family protein 0.00400753 menD 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase 0.00507518 SAEMRSA15_RS09800 metal-dependent hydrolase 0.00516556 graR response regulator transcription factor GraR/ApsR 0.00546077 rsmG 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG 0.00895798...”
Q7UFY5 Cationic amino acid transporter (Cat-1) from Rhodopirellula baltica (strain DSM 10527 / NCIMB 13988 / SH1)
22% identity, 52% coverage
BAT1_MOUSE / Q9QXA6 b(0,+)-type amino acid transporter 1; b(0,+)AT1; Glycoprotein-associated amino acid transporter b0,+AT1; Solute carrier family 7 member 9 from Mus musculus (Mouse) (see 2 papers)
XP_006540108 B(0,+)-type amino acid transporter 1 isoform X1 from Mus musculus
23% identity, 62% coverage
- function: Associates with SLC3A1 to form a functional transporter complex that mediates the electrogenic exchange between cationic amino acids and neutral amino acids, with a stoichiometry of 1:1 (By similarity) (PubMed:10588648). Has system b(0,+)-like activity with high affinity for extracellular cationic amino acids and L-cystine and lower affinity for intracellular neutral amino acids (By similarity). Substrate exchange is driven by high concentration of intracellular neutral amino acids and the intracellular reduction of L-cystine to L- cysteine (By similarity). Required for reabsorption of L-cystine and dibasic amino acids across the brush border membrane in renal proximal tubules (By similarity).
catalytic activity: L-leucine(out) + L-arginine(in) = L-leucine(in) + L- arginine(out) (RHEA:71059)
catalytic activity: L-histidine(out) + L-arginine(in) = L-histidine(in) + L- arginine(out) (RHEA:71063)
catalytic activity: L-phenylalanine(out) + L-arginine(in) = L-phenylalanine(in) + L-arginine(out) (RHEA:71067)
catalytic activity: L-cysteine(out) + L-arginine(in) = L-cysteine(in) + L- arginine(out) (RHEA:71071)
catalytic activity: L-cystine(out) + L-arginine(in) = L-cystine(in) + L- arginine(out) (RHEA:71075)
catalytic activity: L-lysine(out) + L-arginine(in) = L-lysine(in) + L- arginine(out) (RHEA:70827)
subunit: Disulfide-linked heterodimer composed of the catalytic light chain subunit SLC7A9 and the heavy chain subunit SLC3A1. The heterodimer is the minimal functional unit. Assembles in heterotetramers (dimers of heterodimers) and higher order oligomers; the oligomerization is mediated by SLC3A1 likely to prevent degradation and facilitate heteromer trafficking to the plasma membrane (By similarity) (PubMed:10588648). Interacts with CAV1 (By similarity). - Unraveling the Proteomic Landscape of Intestinal Epithelial Cell-Derived Exosomes in Mice.
Ding, Frontiers in physiology 2022 - “...0.845 0.402 Not Enterocyte 28 P18242 Ctsd Cathepsin D 70.48 0.823 0.511 Not Enterocyte 29 Q9QXA6 Slc7a9 b(0, +)-type amino acid transporter 1 54.43 0.806 0.082 Not Enterocyte 30 O88329 Myo1a Unconventional myosin-Ia 4066.40 0.771 0.000 Not Enterocyte 31 Q8VDN2 Atp1a1 Sodium/potassium-transporting ATPase subunit alpha-1 19959.97...”
- Origin and diversification of the basic helix-loop-helix gene family in metazoans: insights from comparative genomics
Simionato, BMC evolutionary biology 2007 - “...gw.168.63.1, gene similar to the uncharacterized Drosophila CG13990 gene; B = estExt_fgenesh1_pm.C_570004, gene similar to Q9QXA6 (Glycoprotein-associated amino acid transporter b0+AT1) from Mus musculus ; C = fgenesh1_pg.scaffold_57000051, gene similar to Drosophila CG18497 . See text and additional file 16 for details. bHLHs from non bilaterians...”
- Tissue distribution, hormonal regulation, ontogeny, diurnal expression, and induction of mouse cystine transporters Slc3a1 and Slc7a9.
Wu, Free radical research 2020 - GeneRIF: Tissue distribution, hormonal regulation, ontogeny, diurnal expression, and induction of mouse cystine transporters Slc3a1 and Slc7a9.
- Slc7a9 knockout mouse is a good cystinuria model for antilithiasic pharmacological studies.
Font-Llitjós, American journal of physiology. Renal physiology 2007 (PubMed)- GeneRIF: A new protocol with d-penicillamine to validate our Slc7a9 knockout mouse model for the study of the therapeutic effect of drugs in the treatment of cystine lithiasis is reported.
- Molecular cloning of mouse amino acid transport system B0, a neutral amino acid transporter related to Hartnup disorder.
Bröer, The Journal of biological chemistry 2004 (PubMed)- GeneRIF: mouse amino acid transport system B0 is a neutral amino acid transporter related to Hartnup disorder
- Slc7a9-deficient mice develop cystinuria non-I and cystine urolithiasis.
Feliubadaló, Human molecular genetics 2003 (PubMed)- GeneRIF: Slc7a9-deficient mice develop cystinuria non-I and cystine urolithiasis
- rBAT-b(0,+)AT heterodimer is the main apical reabsorption system for cystine in the kidney.
Fernández, American journal of physiology. Renal physiology 2002 (PubMed)- GeneRIF: a decreasing expression gradient of heterodimeric rBAT-b(0,+)AT along the proximal tubule is responsible for virtually all apical cystine reabsorption
EQ812_06165 APC family permease from Staphylococcus lugdunensis
23% identity, 65% coverage
- Comparative proteomics analysis of biofilms and planktonic cells of Enterococcus faecalis and Staphylococcus lugdunensis with contrasting biofilm-forming ability
Cho, PloS one 2024 - “...proteins were annotated, including YycI domain-containing protein ( EQ_ EQ812_05590 ), APC family permease ( EQ812_06165 ), NupC/NupG family nucleoside CNT transporter ( EQ812_06755 ), etc., to membrane, transmembrane or transmembrane helix. The resulting pathway networks were analyzed as depicted in Fig 3a and 3b ....”
- “...EQ812_05230, ARJ28872.1 = EQ812_01650, ARJ30410.1 = EQ812_09225, ARJ29784.1 = EQ812_07770, ARJ28661.1 = HMPREF3225_02342, ARJ28536.1 = EQ812_06165, ARJ30089.1 = rihC, ARJ30169.1 = HMPREF3225_00709, ARJ30675.1 = yabA, ARJ29954.1 = HMPREF3225_00598, ARJ28686.1 = HMPREF3225_02322, ARJ29222.1 = HMPREF3225_00188. e and f . Gene ontology (GO) classification. The differentially expressed proteins...”
SAFDA_2310 APC family permease from Staphylococcus aureus
NWMN_2349 hypothetical protein from Staphylococcus aureus subsp. aureus str. Newman
23% identity, 60% coverage
NP_001101143 cystine/glutamate transporter from Rattus norvegicus
23% identity, 62% coverage
MW2374 ORFID:MW2374~hypothetical protein, similar to amino acid transporter from Staphylococcus aureus subsp. aureus MW2
23% identity, 60% coverage
RHA1_ro06083 probable ethanolamine permease, APC superfamily from Rhodococcus sp. RHA1
26% identity, 61% coverage
D4ADU2 Solute carrier family 7 member 11 from Rattus norvegicus
23% identity, 62% coverage
- Syzygium aromaticum Extract Mitigates Doxorubicin-Induced Hepatotoxicity in Male Rats.
Alsirhani, International journal of molecular sciences 2024 - “...(ADMET) [ 64 ]. The protein structures for NRF-2 (Uniprot ID: O54968), SLC7A-11 (Uniprot ID: D4ADU2), and GPX-4 (Uniprot ID: P36970) were collected from the UniProt database, and models were generated using the AlphaFold server [ 65 ]. The active sites of all proteins were predicted...”
- Salidroside Alleviates Renal Fibrosis in SAMP8 Mice by Inhibiting Ferroptosis.
Yang, Molecules (Basel, Switzerland) 2022 - “...1 Potential targets ID. Uniprot ID PDB ID AlphaFord ID Gene Symbol P36970 5l71 GPX4 D4ADU2 Q9WTR6 SLC7A11 O35547 Q9QUJ7 ACSL4 P19132 5xb1 FTH1 Q99376 Q62351 TFR1 Q923U9 Q9JHI9 FPN1 molecules-27-08039-t002_Table 2 Table 2 Gene primer sequence used for qRT-PCR. GPX4 Forward primer CCGCCGAGATGAGCTGG Reverse primer...”
- Hydrogen sulfide increases glutathione biosynthesis, and glucose uptake and utilisation in C2C12 mouse myotubes.
Parsanathan, Free radical research 2018 - “...amino acid sequences of Slc7a11/xCT human (Q9UPY9 in the UniProtKB database), mouse (Q9WTR6), and rat (D4ADU2), and a similar comparison of sequences of Slc2a4/GLUT4 human (P14672), mouse (P14142), and rat (P19357) indicated that the localization of cysteine residues is conserved in all species. Amino acid sequences...”
GBAA5261 amino acid permease family protein from Bacillus anthracis str. 'Ames Ancestor'
26% identity, 53% coverage
SA2239 hypothetical protein from Staphylococcus aureus subsp. aureus N315
SAV2450 amino acid transporter from Staphylococcus aureus subsp. aureus Mu50
23% identity, 60% coverage
XP_065935586 b(0,+)-type amino acid transporter 1 isoform X1 from Magallana gigas
26% identity, 60% coverage
MSMEG_5848 amino acid permease-associated region from Mycobacterium smegmatis str. MC2 155
25% identity, 64% coverage
NP_777038 large neutral amino acids transporter small subunit 1 from Bos taurus
25% identity, 62% coverage
EAM_RS12130 APC family permease from Erwinia amylovora ATCC 49946
24% identity, 63% coverage
STM14_0180 aromatic amino acid transporter AroP from Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S
STM0150 APC family, aromatic amino acid transporter from Salmonella typhimurium LT2
22% identity, 58% coverage
- Integrative DNA methylome and transcriptome analysis reveals DNA adenine methylation is involved in Salmonella enterica Typhimurium response to oxidative stress
Zhang, Microbiology spectrum 2023 - “...protein STM14_0076 STM14_0177 0.76 0.046 Putative cytoplasmic protein STM14_0178 0.84 0.017 Na + /galactoside symporter STM14_0180 aroP 0.84 0.017 Aromatic amino acid transporter STM14_1053 0.90 0.014 Hypothetical protein STM14_1053 STM14_1388 ycfR 0.68 0.05 Putative outer membrane protein STM14_2212 manX 0.82 0.024 Mannose-specific enzyme IIAB STM14_2213 manY...”
- Transcriptomic Responses of Salmonella enterica Serovars Enteritidis in Sodium Hypochlorite
Wang, Frontiers in cellular and infection microbiology 2022 - “...C STM0705 kdpB 3.6 potassium-transporting ATPase subunit KdpB STM0704 kdpA 3.7 potassium-transporting ATPase subunit A STM0150 aroP 3.5 aromatic amino acid transporter AroP STM0399 brnQ 1.4 branched-chain amino acid transporter carrier protein BrnQ STM3560 livF 1.7 branched-chain amino acid ABC transporter ATP-binding protein LivF Carbohydrate and...”
- Detecting non-orthology in the COGs database and other approaches grouping orthologs using genome-specific best hits
Dessimoz, Nucleic acids research 2006 - “...PA0866, 4a: PA5097, 4b: PA0789, 7: PA0129, out: PA2079), Salmonella typhimurium LT2 (1: STM0568, 2: STM0150, 3: STM3930, 4: STM0400, 5: STM4398, 6: STM1584, 7: STM2793), Y.pestis (2a: YPO3421, 2b: YPO1743, 3: YPO3854, 4a: YPO3201, 4b: YPO4015, 5: YPO1859, 6: YPO1937). Table 1 Results of the...”
BtBc_26105 APC family permease from Bacillus thuringiensis
26% identity, 53% coverage
CD1555 putative amino acid permease from Clostridium difficile 630
24% identity, 65% coverage
- Genome-Wide Transcription Start Site Mapping and Promoter Assignments to a Sigma Factor in the Human Enteropathogen Clostridioides difficile
Soutourina, Frontiers in microbiology 2020 - “...GamR-type CD1413/rhaT # CD1413 Membrane protein (RhaT) 0.31 (0.19*) A TGGCA TAGTTT TTGCTT A CD1412/XhaQ CD1555 # CD1555 Putative serine/threonine exchanger 0.36 (0.5*) T TGGCA TAATAT ATGCTT A ? CD1740 # CD1740-CD1741 Sarcosine reductase complex NR T TGGCA TAGAAA ATGCTT T CD1739/SarR, TCS SarRS CD2091 #...”
- “...cysteine ( cdsB and maybe also cysK ) and encoding a probable serine/threonine exchanger ( CD1555 ) or a transporter of cysteine/cystine ( CD2174 operon) ( Dubois et al., 2016 ; Gu et al., 2017 ). Finally, a 24,12 promoter was mapped upstream of the CD1740-CD1741...”
- Vegetative Cell and Spore Proteomes of Clostridioides difficile Show Finite Differences and Reveal Potential Protein Markers
Abhyankar, Journal of proteome research 2019 - “...are also important for germinating spores as they transform into vegetative cells. Proteins CD3458 and CD1555 are putative amino acid permeases identified to be slightly more abundant in spores than in vegetative cells. In addition, protein CD3458 contains a putative amino acid permease domain and an...”
- Clostridium difficile Biofilm: Remodeling Metabolism and Cell Surface to Build a Sparse and Heterogeneously Aggregated Architecture
Poquet, Frontiers in microbiology 2018 - “...opp operon is down-regulated. Several peptidases (Map1-CD0092, CD1228, CD2173, CD2613, and CD2697) and one transporter (CD1555) are presumably overproduced ( Figure 4 ), likely providing biofilm cells with amino acids. On the contrary, genes involved in the biosynthesis of histidine ( hisCBHAF ), branched chain amino...”
- Clostridium difficile extracytoplasmic function σ factor σV regulates lysozyme resistance and is necessary for pathogenesis in the hamster model of infection
Ho, Infection and immunity 2014 - “...proteinb cd0738 cd0739 cd0740 cd1101 cd1114 cd1117 cd1555 cd1556 (pdaV) cd1557 (prsA2) cd1558 (csfV) cd1559 (rsiV) cd1560 cd1561 cd1562 cd1565 cd1605...”
- Genome-wide analysis of cell type-specific gene transcription during spore formation in Clostridium difficile
Saujet, PLoS genetics 2013 - “...E + CD1085 Putative membrane protein 0.26 A CD1085-CD1086 CD1086 Putative peptidase, M20D family 0.26 CD1555 Putative amino acid permease 0.22 CD1746 gltC Sodium/glutamate symporter 0.20 E CD1259 brnQ-1 Branched chain amino acid transporter 0.39 CD2439 Diacylglycerol kinase/undecaprenol kinase 0.45 + CD1068 Polysaccharide biosynthesis protein 0.23...”
- “...activated the expression of genes encoding peptidases (CD3652, CD1086, CD3521) or amino acids permeases (CD1746, CD1555 and CD1259). Moreover, the CD2833 and CD0760 genes encoding a Ca 2+ -transporting ATPase and a Ca 2+ /Na + antiporter, respectively, were downregulated in the sigE mutant. These proteins...”
BAT1_RAT / P82252 b(0,+)-type amino acid transporter 1; b(0,+)AT; Glycoprotein-associated amino acid transporter b0,+AT1; Solute carrier family 7 member 9 from Rattus norvegicus (Rat) (see 2 papers)
TC 2.A.3.8.15 / P82252 The b0,+ amino acid (cystine) transporter associated with the cystinuria-related type II membrane glycoprotein, BAT1 which forms a heterodimer with rBAT (TC# 8.A.9.1.1). Present in the apical membrane of renal proximal tubules from Rattus norvegicus (Rat) (see 2 papers)
24% identity, 60% coverage
- function: Associates with SLC3A1 to form a functional transporter complex that mediates the electrogenic exchange between cationic amino acids and neutral amino acids, with a stoichiometry of 1:1 (By similarity) (PubMed:10506124). Has system b(0,+)-like activity with high affinity for extracellular cationic amino acids and L-cystine and lower affinity for intracellular neutral amino acids (By similarity). Substrate exchange is driven by high concentration of intracellular neutral amino acids and the intracellular reduction of L-cystine to L- cysteine (By similarity). Required for reabsorption of L-cystine and dibasic amino acids across the brush border membrane in renal proximal tubules (By similarity).
catalytic activity: L-leucine(out) + L-arginine(in) = L-leucine(in) + L- arginine(out) (RHEA:71059)
catalytic activity: L-histidine(out) + L-arginine(in) = L-histidine(in) + L- arginine(out) (RHEA:71063)
catalytic activity: L-phenylalanine(out) + L-arginine(in) = L-phenylalanine(in) + L-arginine(out) (RHEA:71067)
catalytic activity: L-cysteine(out) + L-arginine(in) = L-cysteine(in) + L- arginine(out) (RHEA:71071)
catalytic activity: L-cystine(out) + L-arginine(in) = L-cystine(in) + L- arginine(out) (RHEA:71075)
catalytic activity: L-lysine(out) + L-arginine(in) = L-lysine(in) + L- arginine(out) (RHEA:70827)
subunit: Disulfide-linked heterodimer composed of the catalytic light chain subunit SLC7A9 and the heavy chain subunit SLC3A1. The heterodimer is the minimal functional unit. Assembles in heterotetramers (dimers of heterodimers) and higher order oligomers; the oligomerization is mediated by SLC3A1 likely to prevent degradation and facilitate heteromer trafficking to the plasma membrane (By similarity) (PubMed:10506124). Interacts with CAV1 (PubMed:16358225). - substrates: Cystine
Dhaf_1325 amino acid permease-associated region from Desulfitobacterium hafniense DCB-2
21% identity, 60% coverage
LAT2_RABIT / Q9N1Q4 Large neutral amino acids transporter small subunit 2; 4F2-LC5; L-type amino acid transporter 2; Solute carrier family 7 member 8 from Oryctolagus cuniculus (Rabbit) (see paper)
25% identity, 60% coverage
- function: Associates with SLC3A2 to form a functional heterodimeric complex that translocates small and large neutral amino acids with broad specificity and a stoichiometry of 1:1 (PubMed:10631289). Functions as amino acid antiporter mediating the influx of extracellular essential amino acids mainly in exchange with the efflux of highly concentrated intracellular amino acids. Has relatively symmetrical selectivities but strongly asymmetrical substrate affinities at both the intracellular and extracellular sides of the transporter. This asymmetry allows SLC7A8 to regulate intracellular amino acid pools (mM concentrations) by exchange with external amino acids (uM concentration range), equilibrating the relative concentrations of different amino acids across the plasma membrane instead of mediating their net uptake. May play an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane (By similarity). Imports the thyroid hormone diiodothyronine (T2) and to a smaller extent triiodothyronine (T3) but not rT 3 or thyroxine (T4) (By similarity). Mediates the uptake of L-DOPA (By similarity). May participate in auditory function (By similarity).
catalytic activity: L-histidine(in) + L-phenylalanine(out) = L-histidine(out) + L- phenylalanine(in) (RHEA:71003)
catalytic activity: L-tryptophan(in) + L-phenylalanine(out) = L-tryptophan(out) + L-phenylalanine(in) (RHEA:71007)
catalytic activity: L-isoleucine(in) + L-phenylalanine(out) = L-isoleucine(out) + L-phenylalanine(in) (RHEA:71011)
catalytic activity: L-valine(in) + L-phenylalanine(out) = L-valine(out) + L- phenylalanine(in) (RHEA:71019)
catalytic activity: L-leucine(in) + L-phenylalanine(out) = L-leucine(out) + L- phenylalanine(in) (RHEA:71023)
catalytic activity: L-glutamine(in) + L-phenylalanine(out) = L-glutamine(out) + L- phenylalanine(in) (RHEA:71027)
catalytic activity: L-cysteine(in) + L-phenylalanine(out) = L-cysteine(out) + L- phenylalanine(in) (RHEA:71031)
catalytic activity: L-phenylalanine(out) + L-methionine(in) = L-phenylalanine(in) + L-methionine(out) (RHEA:71039)
catalytic activity: L-leucine(out) + L-methionine(in) = L-leucine(in) + L- methionine(out) (RHEA:71051)
catalytic activity: L-cysteine(out) + L-methionine(in) = L-cysteine(in) + L- methionine(out) (RHEA:71055)
catalytic activity: S-methylmercury-L-cysteine(out) + L-methionine(in) = S- methylmercury-L-cysteine(in) + L-methionine(out) (RHEA:71103)
catalytic activity: S-methylmercury-L-cysteine(in) + L-leucine(out) = S- methylmercury-L-cysteine(out) + L-leucine(in) (RHEA:71107)
catalytic activity: S-methylmercury-L-cysteine(in) + L-phenylalanine(out) = S- methylmercury-L-cysteine(out) + L-phenylalanine(in) (RHEA:71111)
catalytic activity: L-serine(in) + L-phenylalanine(out) = L-serine(out) + L- phenylalanine(in) (RHEA:71035)
catalytic activity: L-phenylalanine(out) + glycine(in) = L-phenylalanine(in) + glycine(out) (RHEA:71047)
catalytic activity: L-phenylalanine(out) + L-alanine(in) = L-phenylalanine(in) + L-alanine(out) (RHEA:71043)
catalytic activity: 3,3',5-triiodo-L-thyronine(out) = 3,3',5-triiodo-L- thyronine(in) (RHEA:71811)
catalytic activity: 3,3'-diiodo-L-thyronine(out) = 3,3'-diiodo-L-thyronine(in) (RHEA:71823)
catalytic activity: L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L- phenylalanine(out) (RHEA:71439)
subunit: Disulfide-linked heterodimer composed of the catalytic light chain subunit SLC7A8 and the heavy chain subunit SLC3A2 (PubMed:10631289). SLC3A2 acts as a chaperone for correct plasma membrane trafficking and stabilization of SLC7A8 and modulates the substrate affinity and specificity of SLC7A8. ICAM-1 associates with the heterodimer SLC3A2/SLC7A8; facilitates leucine uptake (By similarity).
ECs0614 phenylalanine-specific transport system from Escherichia coli O157:H7 str. Sakai
Z0715 phenylalanine-specific transport system from Escherichia coli O157:H7 EDL933
22% identity, 62% coverage
- Detecting non-orthology in the COGs database and other approaches grouping orthologs using genome-specific best hits
Dessimoz, Nucleic acids research 2006 - “...2: ZaroP, 3: ZyifK, 4: ZproY, 5: ZcycA, 6: ZansP, 7: ZgabP), E.coli H7 (1: ECs0614, 2: ECs0116, 3: ECs4729, 4: ECs0452, 5: ECs5186, 6: ECs2057, 7: ECs3524), P.aeruginosa (2a: PA3000, 2b: PA0866, 4a: PA5097, 4b: PA0789, 7: PA0129, out: PA2079), Salmonella typhimurium LT2 (1: STM0568,...”
- Enhanced and Stem-Cell-Compatible Effects of Nature-Inspired Antimicrobial Nanotopography and Antimicrobial Peptides to Combat Implant-Associated Infection
Ishak, ACS applied nano materials 2023 - “...min in PBS/0.5% v/v Tween. A secondary antibody (horse anti-mouse IgG, biotinylated, Vector Labs, U.K., Z0715) diluted 1:50 PBS/BSA was added for 1 h at 37 C. The antibody was removed, and the cells were washed three times for 5 min in PBS/0.5% v/v Tween. Streptavidin-FITC...”
- The gluconeogenesis pathway is involved in maintenance of enterohaemorrhagic Escherichia coli O157:H7 in bovine intestinal content
Bertin, PloS one 2014 - “...glnQ Component of glutamine high-affinity transport system 8.47 4.6E-05 Z3413 lysP Lysine-specific permease 2.11 7.2E-03 Z0715 pheP Phenylalanine-specific transport system 2.20 2.8E-03 Gluconeogenic amino acids are both carbon and nitrogen sources for many bacteria: ammonia is first release due to deamination and second, deaminated amino acids...”
STM4398 APC family, D-alanine/D-serine/glycine transport protein from Salmonella typhimurium LT2
23% identity, 55% coverage
- The coenzyme B12 precursor 5,6-dimethylbenzimidazole is a flavin antagonist in Salmonella
Malalasekara, Microbial cell (Graz, Austria) 2023 - “...DNA Technologies, Inc. (IDT, Coralville, IA]), and are listed Table 3 . Genes cycA ( stm4398 ), dctA ( stm3614 ), and tcuC ( stm0689 ) glpF ( stm4087 ) and rbsACB ( stm3882-4 ) were amplified using Phusion high fidelity polymerase (Thermo Fisher Scientific). PCR...”
- Repression of Salmonella enterica phoP expression by small molecules from physiological bile
Antunes, Journal of bacteriology 2012 - “...hybD feoB hypO cutC yhgI yhfA feoA STM2378 STM4398 STM0600 STM3218 STM2389 PSLT052 STM1231 STM4159 STM3557 STM0734 STM0662 ORF01131 STM1238 STM1712 STM0549...”
- Detecting non-orthology in the COGs database and other approaches grouping orthologs using genome-specific best hits
Dessimoz, Nucleic acids research 2006 - “...PA0129, out: PA2079), Salmonella typhimurium LT2 (1: STM0568, 2: STM0150, 3: STM3930, 4: STM0400, 5: STM4398, 6: STM1584, 7: STM2793), Y.pestis (2a: YPO3421, 2b: YPO1743, 3: YPO3854, 4a: YPO3201, 4b: YPO4015, 5: YPO1859, 6: YPO1937). Table 1 Results of the algorithm on the COGs database #...”
PheP / b0576 phenylalanine:H+ symporter PheP from Escherichia coli K-12 substr. MG1655 (see 3 papers)
pheP / P24207 phenylalanine:H+ symporter PheP from Escherichia coli (strain K12) (see 3 papers)
PHEP_ECOLI / P24207 Phenylalanine-specific permease; Phenylalanine:H(+) symporter PheP from Escherichia coli (strain K12) (see 6 papers)
TC 2.A.3.1.1 / P24207 Phenylalanine:H+ symporter, PheP of 458 aas and 12 established TMSs from Escherichia coli (see 6 papers)
b0576 phenylalanine transporter from Escherichia coli str. K-12 substr. MG1655
22% identity, 62% coverage
- function: Permease that is involved in the active transport across the cytoplasmic membrane of phenylalanine (PubMed:10735864, PubMed:1711024, PubMed:8226700, PubMed:9791098). Can also transport tyrosine, but not tryptophan (PubMed:10735864).
catalytic activity: L-phenylalanine(in) + H(+)(in) = L-phenylalanine(out) + H(+)(out) (RHEA:28923) - substrates: phenylalanine
tcdb comment: Catalytic residues have been identified (Pi et al. 1993), and interhelical interactions have been proposed (Dogovski et al. 2003) - YdgG (TqsA) controls biofilm formation in Escherichia coli K-12 through autoinducer 2 transport
Herzberg, Journal of bacteriology 2006 - “...artJ pheP ycfT agaD b4123 b4035 b3266 b0860 b0576 b1115 b3140 6.5 6.1 5.7 5.3 4.9 4.3 4 Putative oxidoreductase; putative methyltransferase Probable formate...”
- Differential gene expression for investigation of Escherichia coli biofilm inhibition by plant extract ursolic acid
Ren, Applied and environmental microbiology 2005 - “...b1225 1.6 0.0022 1.4 0.0281 pheM b1715 1.6 0.0106 pheP b0576 1.5 0.0210 1.1 0.4985 rimL b1427 1.5 0.0220 1.0 0.7185 rmf b0953 1.5 0.0029 1.0 0.6617 rpmI b1717...”
- Biodistribution of 89Zr-DFO-labeled avian pathogenic Escherichia coli outer membrane vesicles by PET imaging in chickens
Li, Poultry science 2023 - “...TOLA Function unknown Cell inner membrane 468 P23886 CYDC Function unknown Cell inner membrane 469 P24207 PHEP Amino acid transport and metabolism Cell inner membrane 470 P25737 LYSP Amino acid transport and metabolism Cell inner membrane 471 P28306 MLTG General function prediction only Cell inner membrane...”
- Functional Characterization of the γ-Aminobutyric Acid Transporter from Mycobacterium smegmatis MC2 155 Reveals Sodium-Driven GABA Transport
Pavić, Journal of bacteriology 2021 - “...), CycA ( O33203 ), YifK ( P27837 ), ProY ( P0AAE2 ), pheP ( P24207 ), LysP ( P25737 ) and YvbW ( O32257 ). A final alignment of this cluster was calculated using Mafft G-INS-I and consisted of 273 sequences. The best-fit evolutionary model...”
- Extracellular loops matter - subcellular location and function of the lysine transporter Lyp1 from Saccharomyces cerevisiae
Van't, The FEBS journal 2020 - “..., Q9UHI5 , and Q9UPY5 corresponding to Lat1, Lat2, and Xct, respectively; and for bacterial, P24207 , P37460 , P25737 , P15993 , P0AAE0 , P25527 , P77610 , P39137 , and P42087 corresponding to PheP, ProY, LysP, AroP, CycA, GabP, AnsP, RocE, and HutM, respectively....”
- Transformation of isopropylamine to L-alaninol by Pseudomonas sp. strain KIE171 involves N-glutamylated intermediates
de, Applied and environmental microbiology 2002 - “...(P29603) GuaA (Escherichia coli) (P04079) PheP (Escherichia coli) (P24207) ALDH2 (Homo sapiens) (P05091) 28.1 (327) 48.0 (100) 33.5 (421) 30.9 (340) 40.3 (64)...”
NP_730006 minidiscs, isoform C from Drosophila melanogaster
23% identity, 63% coverage
YLAT1_MOUSE / Q9Z1K8 Y+L amino acid transporter 1; Solute carrier family 7 member 7; y(+)L-type amino acid transporter 1; Y+LAT1; y+LAT-1 from Mus musculus (Mouse) (see 3 papers)
NP_035535 Y+L amino acid transporter 1 from Mus musculus
26% identity, 62% coverage
- function: Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux route by exporting cationic amino acids from inside the cells in exchange with neutral amino acids plus sodium ions and may participate in nitric oxide synthesis via the transport of L-arginine (PubMed:9878049). Also mediates L-arginine transport in non- polarized cells, such as monocytes, and is essential for the correct function of these cells (By similarity). The transport mechanism is electroneutral and operates with a stoichiometry of 1:1 (By similarity). In vitro, Na(+) and Li(+), but also H(+), are cotransported with the neutral amino acids (By similarity).
catalytic activity: L-leucine(out) + L-arginine(in) + Na(+)(out) = L-leucine(in) + L-arginine(out) + Na(+)(in) (RHEA:70831)
catalytic activity: L-leucine(out) + L-lysine(in) + Na(+)(out) = L-leucine(in) + L-lysine(out) + Na(+)(in) (RHEA:74971)
catalytic activity: L-leucine(out) + L-ornithine(in) + Na(+)(out) = L-leucine(in) + L-ornithine(out) + Na(+)(in) (RHEA:74963)
subunit: Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc.
disruption phenotype: A mouse model for human lysinuric protein intolerance (LPI), where homozygous knockout mice for Slc7a7 gene are born at a frequency lower than the expected Mendelian ratio (PubMed:17376816). Only two homozygous mice survived, whereas 16 of them died within 24 hours of birth (PubMed:17376816). Growth retardation is an ongoing feature of the two surviving mice kept on a low-protein diet with citrulline supplementation. After a planned withdrawal of the special diet both mice show an acute metabolic derangement, identical to that found in human LPI, leading to death of both animals after severe hyperammonemic neurological symptoms (PubMed:17376816). Tamoxifen-inducible Slc7a7 homozygous knockout mice model resembles the human LPI phenotype, including malabsorption and impaired reabsorption of cationic amino acid (CAA), hypoargininemia and hyperammonemia. Mice also develops pulmonar alveolar proteinosis (PAP) and neurological impairment (PubMed:31653080). - CRISPR-Cas9/phosphoproteomics identifies multiple noncanonical targets of myosin light chain kinase.
Isobe, American journal of physiology. Renal physiology 2020 - Loss of LAT1 sex-dependently delays recovery after caerulein-induced acute pancreatitis.
Hagen, World journal of gastroenterology 2022 - GeneRIF: Loss of LAT1 sex-dependently delays recovery after caerulein-induced acute pancreatitis.
- Quantitative Proteomics Reveals the Development of HBV-Associated Glomerulonephritis Triggered by the Downregulation of SLC7A7.
Zuo, Journal of proteome research 2020 (PubMed)- GeneRIF: Quantitative Proteomics Reveals the Development of HBV-Associated Glomerulonephritis Triggered by the Downregulation of SLC7A7.
- A global Slc7a7 knockout mouse model demonstrates characteristic phenotypes of human lysinuric protein intolerance.
Stroup, Human molecular genetics 2020 - GeneRIF: A global Slc7a7 knockout mouse model demonstrates characteristic phenotypes of human lysinuric protein intolerance.
- Developmental and cell type-specific expression of thyroid hormone transporters in the mouse brain and in primary brain cells.
Braun, Glia 2011 (PubMed)- GeneRIF: The expression of Mct8 and L-type amino acid transporters Lat2 and Lat1 are determined in brain neurons during development.
- The monocarboxylate transporter 8 and L-type amino acid transporters 1 and 2 are expressed in mouse skeletons and in osteoblastic MC3T3-E1 cells.
Capelo, Thyroid : official journal of the American Thyroid Association 2009 (PubMed)- GeneRIF: LAT1, and LAT2 mRNAs were detected in fetal and postnatal femurs and in MC3T3-E1 cells, while OATP1 and NTCP mRNAs were not.
- Characterization and astrocytic modulation of system L transporters in brain microvasculature endothelial cells.
Omidi, Cell biochemistry and function 2008 (PubMed)- GeneRIF: System L functions as influx and/or efflux transport machinery displaying a greater propensity for the outward transport of large and small neutral amino acids.
- Regulation of renal amino acid transporters during metabolic acidosis.
Moret, American journal of physiology. Renal physiology 2007 (PubMed)- GeneRIF: selective regulation of SNAT3 and y(+)LAT1 expression may serve a major role in the renal adaptation to acid secretion and thus for systemic acid-base balance.
- Slc7a7 disruption causes fetal growth retardation by downregulating Igf1 in the mouse model of lysinuric protein intolerance.
Sperandeo, American journal of physiology. Cell physiology 2007 (PubMed)- GeneRIF: The Slc7a7(-/-) mouse displayed intrauterine growth restriction, leading to neonatal lethality. After heavy protein ingestion, the surviving adult animals presented metabolic derangement consistent with lysinuric protein intolerance.
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PA14_54040 probable amino acid permease from Pseudomonas aeruginosa UCBPP-PA14
24% identity, 55% coverage
PP1229 amino acid transporter, putative from Pseudomonas putida KT2440
24% identity, 61% coverage
PA0789 probable amino acid permease from Pseudomonas aeruginosa PAO1
24% identity, 55% coverage
- Responses of carbapenemase-producing and non-producing carbapenem-resistant Pseudomonas aeruginosa strains to meropenem revealed by quantitative tandem mass spectrometry proteomics
Salvà-Serra, Frontiers in microbiology 2022 - “...PA0605 AgtC AgtC 6 15 1.09 0.20 1.09 0.24 2.59 0.00 Down 1.12 0.08 WP_003085613.1 PA0789 - Probable amino acid permease 5 13 1.02 0.91 1.50 0.00 Up 4.69 0.00 Up 1.80 0.00 Lower WP_003085934.1 PA0889 AotQ Arginine/ornithine transport protein AotQ 3 9 1.09 0.58 1.24...”
- Differential transcription profiling of the phage LUZ19 infection process in different growth media
Brandão, RNA biology 2021 (secret) - Seawater salt-trapped Pseudomonas aeruginosa survives for years and gets primed for salinity tolerance
Elabed, BMC microbiology 2019 - “...cysT PA0282 2.55 0.0016 Probable amino acid permease PA3641 2.46 0.0012 Probable amino acid permease PA0789 2.37 0.0076 Probable ATP-binding component of ABC transporter PA3019* 2.24 0.0030 Metabolism/enzymes S-adenosylmethionine decarboxylase proenzyme speD PA0654* 2.66 0.00038 Aspartate ammonia-lyase aspA PA5429 2.56 0.0029 Sulfite reductase cysI PA1838 2.47...”
- “...transporters are putative components of ABC transporters (PA2204, PA3019), and putative amino acid permeases (PA3641, PA0789). Additionally, three genes (a probable AGCS Na + /alanine/glycine symporter PA2252, a probable amino acid permease PA3641, and nqrB PA2998) involved in Na + ions transport (GO:0006814) were induced in...”
- The development of a new parameter for tracking post-transcriptional regulation allows the detailed map of the Pseudomonas aeruginosa Crc regulon
Corona, Scientific reports 2018 - “...dehydrogenase PutA 3,29 1,79 8,38 Transport putP PA0783 Sodium/proline symporter PutP 0,79 1,58 5,3 Transport PA0789 Probable amino acid permease 0,38 0,86 2,08 Iron pirA PA0931 Ferric enterobactin receptor PirA 0,29 0,97 2,48 Transport tolQ PA0969 TolQ protein 0,41 1,03 2,52 Transport tolR PA0970 TolR protein...”
- High-throughput phenotypic characterization of Pseudomonas aeruginosa membrane transport genes
Johnson, PLoS genetics 2008 - “...periplasmic binding protein PA0322 PAK cationic amino acid APC family transporter PA0783 PAK proline/sodium transporter PA0789 PAK proline APC family transporter PA0866 PAK aromatic amino acid APC family transporter PA0888 PAK pili- arginine/ornithine ABC transporter periplasmic binding protein ( AotJ ) PA0889 PA01 arginine/ornithine ABC transporter...”
- Detecting non-orthology in the COGs database and other approaches grouping orthologs using genome-specific best hits
Dessimoz, Nucleic acids research 2006 - “...ECs0452, 5: ECs5186, 6: ECs2057, 7: ECs3524), P.aeruginosa (2a: PA3000, 2b: PA0866, 4a: PA5097, 4b: PA0789, 7: PA0129, out: PA2079), Salmonella typhimurium LT2 (1: STM0568, 2: STM0150, 3: STM3930, 4: STM0400, 5: STM4398, 6: STM1584, 7: STM2793), Y.pestis (2a: YPO3421, 2b: YPO1743, 3: YPO3854, 4a: YPO3201,...”
CDR20291_2931 putative amino acid permease from Clostridium difficile R20291
24% identity, 60% coverage
lpg0049 amino acid transporter, permease from Legionella pneumophila subsp. pneumophila str. Philadelphia 1
25% identity, 58% coverage
- Mammalian Solute Carrier (SLC)-like transporters of Legionella pneumophila
Best, Scientific reports 2018 - “...SLC2a1 (0.922) LstC (Lpg0026) 37% 56% Cationic amino acids (arginine, lysine, ornithine) SLC7a1 (0.953) LstD (Lpg0049) 25% 44% Cationic amino acids (arginine, lysine, ornithine) SLC7a5 (0.954) LstE (Lpg0228) 25% 42% Cationic amino acids (arginine, lysine, ornithine) SLC7a1 (0.848) LstF (Lpg0281) 25% 53% Cationic amino acids (arginine,...”
- Transcriptomic changes of Legionella pneumophila in water
Li, BMC genomics 2015 - “...1.91 3.42 5.45 Amino acid permease family protein lpg0228 2.77 5.41 6.13 Amino acid transporter lpg0049 3.27 Ferrous iron transporter lpg2658 feoA 2.56 2.80 4.47 Ferrous iron transporter lpg2657 feoB 3.10 5.23 DotA lpg2686 dotA 1.35 DotC lpg2675 dotC 1.40 2.29 4.72 DotD lpg2674 dotD 1.46...”
PSPPH_4866 proline-specific permease proY from Pseudomonas syringae pv. phaseolicola 1448A
23% identity, 56% coverage
SGR_6475 putative ethanolamine permease from Streptomyces griseus subsp. griseus NBRC 13350
25% identity, 61% coverage
DagA / b4208 D-serine/alanine/glycine/:H+symporter from Escherichia coli K-12 substr. MG1655 (see 13 papers)
cycA / P0AAE0 D-serine/alanine/glycine:H+symporter from Escherichia coli (strain K12) (see 15 papers)
CYCA_ECOLI / P0AAE0 D-serine/D-alanine/glycine transporter; Amino acid carrier CycA from Escherichia coli (strain K12) (see 7 papers)
TC 2.A.3.1.7 / P0AAE0 D-Serine/D-alanine/glycine/D-cycloserine:H+ symporter from Escherichia coli (see 4 papers)
NP_418629 D-serine/alanine/glycine/:H(+)symporter from Escherichia coli str. K-12 substr. MG1655
b4208 D-alanine/D-serine/glycine transporter from Escherichia coli str. K-12 substr. MG1655
ECs5186 transport protein of D-alanine / D-serine / glycine from Escherichia coli O157:H7 str. Sakai
23% identity, 56% coverage
- function: Permease that is involved in the transport across the cytoplasmic membrane of D-alanine, D-serine, glycine and beta-alanine (PubMed:15221223, PubMed:23316042, PubMed:4574696, PubMed:4583203, PubMed:4926674). Also contributes to L-alanine uptake (PubMed:4574696, PubMed:4583203). In addition, in minimal media, transports the broad spectrum antibiotic D-cycloserine into the cell (PubMed:23316042, PubMed:4574696, PubMed:4926674). Transports D-cycloserine only in minimal media, and not in a complex medium, suggesting that CycA does not play a role in D-cycloserine transport when E.coli is grown in a complex or biologically relevant medium, probably due to competition from other CycA substrates present in the medium (PubMed:23316042).
catalytic activity: D-alanine(in) + H(+)(in) = D-alanine(out) + H(+)(out) (RHEA:28903)
catalytic activity: D-serine(out) + H(+)(out) = D-serine(in) + H(+)(in) (RHEA:70647)
catalytic activity: glycine(in) + H(+)(in) = glycine(out) + H(+)(out) (RHEA:28899)
catalytic activity: beta-alanine(in) + H(+)(in) = beta-alanine(out) + H(+)(out) (RHEA:29459)
catalytic activity: L-alanine(in) + H(+)(in) = L-alanine(out) + H(+)(out) (RHEA:29443)
catalytic activity: D-cycloserine(in) + H(+)(in) = D-cycloserine(out) + H(+)(out) (RHEA:70703)
disruption phenotype: Mutant exhibits increased resistance to D- cycloserine when grown in a minimal medium, but no change in D- cycloserine sensitivity compared to its parental strain when grown in a complex medium. - substrates: D-alanine, D-cycloserine, D-serine, Glycine, H+, Serine
tcdb comment: The system is active after growth in minimal medium but not after growth in complex medium (Baisa et al. 2013) - CycA-Dependent Glycine Assimilation Is Connected to Novobiocin Susceptibility in Escherichia coli.
Shi, Microbiology spectrum 2022 - GeneRIF: CycA-Dependent Glycine Assimilation Is Connected to Novobiocin Susceptibility in Escherichia coli.
- Identification and characterization of the main beta-alanine uptake system in Escherichia coli.
Schneider, Applied microbiology and biotechnology 2004 (PubMed)- GeneRIF: beta-Alanine uptake was found to be an active process catalyzed by the amino acid carrier CycA.
- Biodistribution of 89Zr-DFO-labeled avian pathogenic Escherichia coli outer membrane vesicles by PET imaging in chickens
Li, Poultry science 2023 - “...membrane 454 P0A9R7 FTSE Cell cycle control, cell division, chromosome partitioning Cell inner membrane 455 P0AAE0 CYCA Amino acid transport and metabolism Cell inner membrane 456 P0AAH8 SAPF Function unknown Cell inner membrane 457 P0ABG7 RODA Cell cycle control, cell division, chromosome partitioning Cell inner membrane...”
- A Continuous Assay Set to Screen and Characterize Novel Protein N-Acetyltransferases Unveils Rice General Control Non-repressible 5-Related N-Acetyltransferase2 Activity
Asensio, Frontiers in plant science 2022 - “...0.20.1 83.44.7 P0ABB0 ATPA ATP synthase subunit alpha (EC 7.1.2.2) 1 - MQLNSTEISE 0.50.3 83.69.5 P0AAE0 CYCA D-serine/D-alanine/glycine transporter 2 M VDQVKVVADD 39.8 82.71.6 P75838 YCAO Ribosomal protein S12 methylthiotransferase accessory factor YcaO 2 M TQTFIPGKDA 1.00.6 81.41.2 P0A9S3 GATD Galactitol 1-phosphate 5-dehydrogenase (EC 1.1.1.251) 1...”
- Extracellular loops matter - subcellular location and function of the lysine transporter Lyp1 from Saccharomyces cerevisiae
Van't, The FEBS journal 2020 - “...Lat2, and Xct, respectively; and for bacterial, P24207 , P37460 , P25737 , P15993 , P0AAE0 , P25527 , P77610 , P39137 , and P42087 corresponding to PheP, ProY, LysP, AroP, CycA, GabP, AnsP, RocE, and HutM, respectively. This resulted in a population of 450, 105,...”
- The Escherichia coli Amino Acid Uptake Protein CycA: Regulation of Its Synthesis and Practical Application in l-Isoleucine Production
Hook, Microorganisms 2022 - “...of d -serine on cell growth [ 28 ] and assumed that the gene cycA (b4208) was responsible for d -cycloserine transport in E. coli , as was earlier shown by Wargel et al. [ 29 ]. Further investigations of the amino acid transport systems expanded...”
- Genome-wide analysis of fitness data and its application to improve metabolic models
Vitkin, BMC bioinformatics 2018 - “...candidate (with Bayesian confidence of ~4% and unbiased confidence of ~98.97%, see Methods) is cycA (b4208), which can act as an L-alanine transporter [ 34 , 35 ]. Another example is the internal reaction CMPN (CMP nucleosidase: CMP + H2OCytosine + D-Ribose-5P ), for which the...”
- Effect of Global Regulators RpoS and Cyclic-AMP/CRP on the Catabolome and Transcriptome of Escherichia coli K12 during Carbon- and Energy-Limited Growth
Franchini, PloS one 2015 - “...12.5 actP f b4067 acetate permease 10.7 alsB b4088 D-allose-binding periplasmic protein -3.2 ** cycA b4208 transport of D-alanine, D-serine, and glycine 4.0 ytfQ b4227 putative D-ribose transport protein, ABC superfamily 3.6 ytfR b4228 putative ATP-binding component of a transport system 5.2 idnT f , g...”
- Evolutionary dynamics of small RNAs in 27 Escherichia coli and Shigella genomes
Skippington, Genome biology and evolution 2012 - “...gltL b0652 gcvB 26 Variable Incongruent No livK b3458 gcvB 27 Core Congruent No cycA b4208 gcvB 27 Core Incongruent Yes livJ b3460 gcvB 27 Core Incongruent Yes galK b0757 spf 27 Core Incongruent No Units of genetic transfer and recombination do not necessarily correspond to...”
- RNApredator: fast accessibility-based prediction of sRNA targets
Eggenhofer, Nucleic acids research 2011 - “...metE b3829 5(8) 120(37) NC_000913 E.c.K. FnrS sodB b1656 24(21) 615(192) NC_000913 E.c.K. GcvB cycA b4208 37(5) 41(10) NC_000913 E.c.K. IstR tisB b4405 2(NF) NF(NF) NC_000913 E.c.K. MicA phoP b1130 80(23) 57(10) NC_000913 E.c.K. MicC ompC b2215 2(5) 2(2) NC_000913 E.c.K. MicF ompF b0929 43(5) 2(2)...”
- Differential gene expression for investigation of Escherichia coli biofilm inhibition by plant extract ursolic acid
Ren, Applied and environmental microbiology 2005 - “...soxS b4062 1.2 0.3597 1.4 0.0069 2.1 Transport cycA dcuA b4208 b4138 1.5 0.0005 1.6 0.0074 1.4 0.0170 1.5 0.0004 b1312 bglF fhuD b1312 b3722 b0152 1.0 1.0000...”
- Microarray analysis of transposition targets in Escherichia coli: the impact of transcription
Manna, Proceedings of the National Academy of Sciences of the United States of America 2004 - “...b4322 b2920 b0863 b4161 b3409 b0208 b4323 b4180 b2672 b2592 b4208 b0365 Gene yidP ybjP intC artP ytfE yafB yrfD ytfF thyA yfiH dgkA yhgG yrfG uxuA ygfH artl...”
- Interfering with different steps of protein synthesis explored by transcriptional profiling of Escherichia coli K-12
Sabina, Journal of bacteriology 2003 - “...b3517 b3509 b2019 b3856 b1260 b0074 b3829 b2599 b2215 b3196 b4208 b0431 b1263 b4016 b0720 b3458 0.04 0.07 0.08 0.08 0.08 0.09 0.11 0.11 0.11 0.14 0.14 0.14 0.15...”
- More
- Detecting non-orthology in the COGs database and other approaches grouping orthologs using genome-specific best hits
Dessimoz, Nucleic acids research 2006 - “...6: ZansP, 7: ZgabP), E.coli H7 (1: ECs0614, 2: ECs0116, 3: ECs4729, 4: ECs0452, 5: ECs5186, 6: ECs2057, 7: ECs3524), P.aeruginosa (2a: PA3000, 2b: PA0866, 4a: PA5097, 4b: PA0789, 7: PA0129, out: PA2079), Salmonella typhimurium LT2 (1: STM0568, 2: STM0150, 3: STM3930, 4: STM0400, 5: STM4398,...”
CD3092 putative amino acid permease from Clostridium difficile 630
24% identity, 60% coverage
XP_039288486 b(0,+)-type amino acid transporter 1-like isoform X1 from Nilaparvata lugens
23% identity, 63% coverage
lpg0228 amino acid permease family protein from Legionella pneumophila subsp. pneumophila str. Philadelphia 1
25% identity, 61% coverage
- Mammalian Solute Carrier (SLC)-like transporters of Legionella pneumophila
Best, Scientific reports 2018 - “...SLC7a1 (0.953) LstD (Lpg0049) 25% 44% Cationic amino acids (arginine, lysine, ornithine) SLC7a5 (0.954) LstE (Lpg0228) 25% 42% Cationic amino acids (arginine, lysine, ornithine) SLC7a1 (0.848) LstF (Lpg0281) 25% 53% Cationic amino acids (arginine, lysine, ornithine) SLC7a1 (0.985) LstG (Lpg0970) 25% 44% Cationic amino acids (arginine,...”
- Transcriptomic changes of Legionella pneumophila in water
Li, BMC genomics 2015 - “...2.51 4.11 4.80 Amino acid permeases lpg0970 1.91 3.42 5.45 Amino acid permease family protein lpg0228 2.77 5.41 6.13 Amino acid transporter lpg0049 3.27 Ferrous iron transporter lpg2658 feoA 2.56 2.80 4.47 Ferrous iron transporter lpg2657 feoB 3.10 5.23 DotA lpg2686 dotA 1.35 DotC lpg2675 dotC...”
- Small Regulatory RNA and Legionella pneumophila
Faucher, Frontiers in microbiology 2011 - “...lpr0006 74969 74729 240 lpg0066 Weissenmayer et al. ( 2011 ) lpr0008 262101 262297 196 lpg0228 Weissenmayer et al. ( 2011 ) lpr0009 291705 291852 147 lpg0245 Weissenmayer et al. ( 2011 ) lpr0012 369510 369457 53 lpg0320 Weissenmayer et al. ( 2011 ) lpr0015 425773...”
B7D75_21325 amino acid permease from Pseudomonas paraeruginosa
25% identity, 55% coverage
ACX60_11495 APC family permease from Acinetobacter baumannii
23% identity, 63% coverage
Z4731 putative amino acid/amine transport protein from Escherichia coli O157:H7 EDL933
23% identity, 65% coverage
- Clonal and antigenic analysis of serogroup A Neisseria meningitidis with particular reference to epidemiological features of epidemic meningitis in the People's Republic of China
Wang, Infection and immunity 1992 - “...IIa, IIb IIa, IIb I Z4727, Z4728, Z4729, Z4730, Z4731, Z4732, B54, B516, B236 B303 B328, B506 Z3510, Z3515 Z3771, Z3786, Z3787 Z3905, Z3909 B503, Z3917, Z3921,...”
YhfM / b3370 fructoselysine/psicoselysine transporter from Escherichia coli K-12 substr. MG1655 (see 4 papers)
frlA / P45539 fructoselysine/psicoselysine transporter from Escherichia coli (strain K12) (see 4 papers)
FRLA_ECOLI / P45539 Probable fructoselysine/psicoselysine transporter FrlA from Escherichia coli (strain K12) (see paper)
b3370 putative amino acid/amine transport protein from Escherichia coli str. K-12 substr. MG1655
23% identity, 65% coverage
TC 2.A.3.5.1 / Q53148 Ethanolamine import permease from Rhodococcus erythropolis (see 2 papers)
25% identity, 61% coverage
K3G22_02305 APC family permease from Shewanella putrefaciens
23% identity, 62% coverage
SLC7A8 / Q9UHI5 large neutral amino acids transporter small subunit 2 from Homo sapiens (see 4 papers)
LAT2_HUMAN / Q9UHI5 Large neutral amino acids transporter small subunit 2; L-type amino acid transporter 2; hLAT2; Solute carrier family 7 member 8 from Homo sapiens (Human) (see 14 papers)
TC 2.A.3.8.20 / Q9UHI5 Large neutral amino acids transporter small subunit 2 (L-type amino acid transporter 2) (hLAT2) (Solute carrier family 7 member 8). Certain detergents stabilize and allow purification of the 4F2hc-LAT2 complex, allowing the measurement of substrate binding. In addition, an improved 3D map could be obtained from Homo sapiens (see 12 papers)
NP_036376 large neutral amino acids transporter small subunit 2 isoform a from Homo sapiens
25% identity, 60% coverage
- function: Associates with SLC3A2 to form a functional heterodimeric complex that translocates small and large neutral amino acids with broad specificity and a stoichiometry of 1:1. Functions as amino acid antiporter mediating the influx of extracellular essential amino acids mainly in exchange with the efflux of highly concentrated intracellular amino acids (PubMed:10391915, PubMed:11311135, PubMed:11847106, PubMed:12716892, PubMed:15081149, PubMed:15918515, PubMed:29355479, PubMed:33298890, PubMed:34848541). Has relatively symmetrical selectivities but strongly asymmetrical substrate affinities at both the intracellular and extracellular sides of the transporter (PubMed:11847106). This asymmetry allows SLC7A8 to regulate intracellular amino acid pools (mM concentrations) by exchange with external amino acids (uM concentration range), equilibrating the relative concentrations of different amino acids across the plasma membrane instead of mediating their net uptake (PubMed:10391915, PubMed:11847106). May play an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney (PubMed:12716892). Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity (PubMed:12117417). Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L- nitrosocysteine (L-CNSO) across the transmembrane (PubMed:15769744). Imports the thyroid hormone diiodothyronine (T2) and to a smaller extent triiodothyronine (T3) but not rT 3 or thyroxine (T4) (By similarity). Mediates the uptake of L-DOPA (By similarity). May participate in auditory function (By similarity).
catalytic activity: L-histidine(in) + L-phenylalanine(out) = L-histidine(out) + L- phenylalanine(in) (RHEA:71003)
catalytic activity: L-tryptophan(in) + L-phenylalanine(out) = L-tryptophan(out) + L-phenylalanine(in) (RHEA:71007)
catalytic activity: L-isoleucine(in) + L-phenylalanine(out) = L-isoleucine(out) + L-phenylalanine(in) (RHEA:71011)
catalytic activity: L-valine(in) + L-phenylalanine(out) = L-valine(out) + L- phenylalanine(in) (RHEA:71019)
catalytic activity: L-leucine(in) + L-phenylalanine(out) = L-leucine(out) + L- phenylalanine(in) (RHEA:71023)
catalytic activity: L-glutamine(in) + L-phenylalanine(out) = L-glutamine(out) + L- phenylalanine(in) (RHEA:71027)
catalytic activity: L-cysteine(in) + L-phenylalanine(out) = L-cysteine(out) + L- phenylalanine(in) (RHEA:71031)
catalytic activity: L-phenylalanine(out) + L-methionine(in) = L-phenylalanine(in) + L-methionine(out) (RHEA:71039)
catalytic activity: L-leucine(out) + L-methionine(in) = L-leucine(in) + L- methionine(out) (RHEA:71051)
catalytic activity: L-cysteine(out) + L-methionine(in) = L-cysteine(in) + L- methionine(out) (RHEA:71055)
catalytic activity: S-methylmercury-L-cysteine(out) + L-methionine(in) = S- methylmercury-L-cysteine(in) + L-methionine(out) (RHEA:71103)
catalytic activity: S-methylmercury-L-cysteine(in) + L-leucine(out) = S- methylmercury-L-cysteine(out) + L-leucine(in) (RHEA:71107)
catalytic activity: S-methylmercury-L-cysteine(in) + L-phenylalanine(out) = S- methylmercury-L-cysteine(out) + L-phenylalanine(in) (RHEA:71111)
catalytic activity: L-serine(in) + L-phenylalanine(out) = L-serine(out) + L- phenylalanine(in) (RHEA:71035)
catalytic activity: L-phenylalanine(out) + glycine(in) = L-phenylalanine(in) + glycine(out) (RHEA:71047)
catalytic activity: L-phenylalanine(out) + L-alanine(in) = L-phenylalanine(in) + L-alanine(out) (RHEA:71043)
catalytic activity: 3,3'-diiodo-L-thyronine(out) = 3,3'-diiodo-L-thyronine(in) (RHEA:71823)
catalytic activity: 3,3',5-triiodo-L-thyronine(out) = 3,3',5-triiodo-L- thyronine(in) (RHEA:71811)
catalytic activity: L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L- phenylalanine(out) (RHEA:71439)
subunit: Disulfide-linked heterodimer composed of the catalytic light chain subunit SLC7A8 and the heavy chain subunit SLC3A2. SLC3A2 acts as chaperones for correct plasma membrane trafficking and stabilization of SLC7A8 and modulates the substrate affinity and specificity of SLC7A8 (PubMed:10391915, PubMed:10574970, PubMed:11311135, PubMed:15769744, PubMed:15918515, PubMed:33066406, PubMed:33298890, PubMed:34848541). ICAM-1 associates with the heterodimer SLC3A2/SLC7A8; this interaction regulates SLC7A8 activity (PubMed:12716892). - substrates: Alanine, Asparagine, Cystine, Glutamine, Glycine, Isoleucine, Leucine, Methionine, Proline, Serine, T2, T3, Threonine, Valine, phenylalanine, tryptophan, tyrosine
tcdb comment: Transports many amino acids including thyroid hormones 3',3-T2 and T3 (Hinz et al. 2015; Kinne et al. 2015) - They all rock: A systematic comparison of conformational movements in LeuT-fold transporters.
Licht, bioRxiv : the preprint server for biology 2024 - “...arginine cryo-EM 2.3 Ec GadC P63235 4DJK (A) I op n/a X-ray 3.097 Hs LAT2 Q9UHI5 7CMI (B) I op leucine cryo-EM 2.9 Hs xCT Q9UPY5 7CCS (B) I op n/a cryo-EM 6.2 Pm CaiT B4EY22 2WSW (A) I op n/a X-ray 2.294 Ec CaiT P31553...”
- Utilization of AlphaFold2 to Predict MFS Protein Conformations after Selective Mutation.
Xiao, International journal of molecular sciences 2022 - “...of other family transporters including members of the amino acid-polyamine-organocation (APC) superfamily (UniProt ID: P0AAF1, Q9UHI5), mitochondrial carrier family (UniProt ID: Q00325), and nucleotide-sugar transporter family (UniProt ID: P78381). Protein members of these families have significantly different topologies and do not have obvious N- and C-terminal...”
- “...outward to inward conformation (UniProt ID: P0AAF1, Q00325) and inward to outward conformation (UniProt ID: Q9UHI5, P78381) ( Figure 4 ). The RMSD of Ca between the wild-type structure and mutant structure was 1.63 (UniProt ID: P0AAF1), 2.17 (UniProt ID: Q9UHI5), 2.77 (UniProt ID: Q00325) and...”
- Histamine, Metabolic Remodelling and Angiogenesis: A Systems Level Approach.
Moya-García, Biomolecules 2021 - “...therapy of cancer Pentose phosphate pathway SLC7A8 amino acid transporter light chain, L system LAT2 Q9UHI5 Neutral amino acid cytosolic exchanger. It is involved in glutamine-dependent mTOR activation to promote glycolysis in cancer cells. Amino acid metabolism solute carrier family 38 member 2 SLC38A2 Q96QD8 It...”
- Extracellular loops matter - subcellular location and function of the lysine transporter Lyp1 from Saccharomyces cerevisiae.
Van't, The FEBS journal 2020 - “...Gnp1, Bap2, hip1, Sam3, Tat1, Tat2, Put4, Dip5, and Agp2, respectively; for mammalian, Q01650 , Q9UHI5 , and Q9UPY5 corresponding to Lat1, Lat2, and Xct, respectively; and for bacterial, P24207 , P37460 , P25737 , P15993 , P0AAE0 , P25527 , P77610 , P39137 , and...”
- Sub-Nanometer Cryo-EM Density Map of the Human Heterodimeric Amino Acid Transporter 4F2hc-LAT2.
Jeckelmann, International journal of molecular sciences 2020 - “...amino acid sequence alignment between human LAT1 (UniProt ID: Q01650) and human LAT2 (UniProt ID: Q9UHI5) was calculated by employing the web application EMBOSS needle ( https://www.ebi.ac.uk/Tools/psa/emboss_needle/ [ 41 ]), and the sequence identity and similarity were determined to be 48% and 65%, as indicated above....”
- “...]) in an automated fashion using the amino acid sequence of human LAT2 (UniProt ID: Q9UHI5) as input. The best model was built based on the coordinates of the cryo-EM structure of 4F2hc-LAT1 (PDB code 6IRS chain B). The resulting LAT2 homology model (LAT2 hom )...”
- Comprehensive proteogenomic analysis of human embryonic and induced pluripotent stem cells.
Parrotta, Journal of cellular and molecular medicine 2019 - “...domaincontaining protein 1B 1.49 0.57 0.009 P53007 SLC25A1 Tricarboxylate transport protein, mitochondrial 1.44 0.53 0.009 Q9UHI5 SLC7A8 Large neutral amino acids transporter small subunit 2 1.43 0.52 0.016 P31641 SLC6A6 Sodium and chloridedependent taurine transporter 1.41 0.50 0.032 Q99541 PLIN2 Perilipin2 0.71 0.50 0.009 H7BYV1 IFITM2...”
- Insights into the Structure, Function, and Ligand Discovery of the Large Neutral Amino Acid Transporter 1, LAT1.
Singh, International journal of molecular sciences 2018 - “...sequence alignment comprised amino acid sequences of LAT1 (UniProt accession number: Q01650, organism: Human), LAT2 (Q9UHI5, Human), Uga4 (P32837, Saccharomyces cerevisiae ), Cat6 (Q9LZ20, Arabidopsis thaliana ), GadC (P63235, Escherichia coli ), AdiC (P60061, E. coli ), CadB (P0AAE8, E. coli ), and PotE (P0AAF1, E....”
- Effects of Mutations and Ligands on the Thermostability of the l-Arginine/Agmatine Antiporter AdiC and Deduced Insights into Ligand-Binding of Human l-Type Amino Acid Transporters.
Ilgü, International journal of molecular sciences 2018 - “...entry codes of the used proteins are: P60061 (AdiC), Q01650 (SCL7A5), Q92536 (SLC7A6), Q9UM01 (SLC7A7), Q9UHI5 (SLC7A8), P82251 (SLC7A9), Q9NS82 (SLC7A10), Q9UPY5 (SLC7A11), and Q8TCU3 (SLC7A13). 3.5. Homology Models and Ligand Docking We show a previously published homology model of LAT1 bound to phenylalanine, which was...”
- More
- SLC7A8 overexpression inhibits the growth and metastasis of lung adenocarcinoma and is correlated with a dismal prognosis.
Wang, Aging 2024 - GeneRIF: SLC7A8 overexpression inhibits the growth and metastasis of lung adenocarcinoma and is correlated with a dismal prognosis.
- Evidence for a relationship between genetic polymorphisms of the L-DOPA transporter LAT2/4F2hc and risk of hypertension in the context of chronic kidney disease.
Crocco, BMC medical genomics 2024 - GeneRIF: Evidence for a relationship between genetic polymorphisms of the L-DOPA transporter LAT2/4F2hc and risk of hypertension in the context of chronic kidney disease.
- Identification and verification of microRNA signature and key genes in the development of osteosarcoma with lung metastasis.
Meng, Medicine 2022 - GeneRIF: Identification and verification of microRNA signature and key genes in the development of osteosarcoma with lung metastasis.
- Genomic and epigenomic evolution of acquired resistance to combination therapy in esophageal squamous cell carcinoma.
Min, JCI insight 2021 - GeneRIF: Genomic and epigenomic evolution of acquired resistance to combination therapy in esophageal squamous cell carcinoma.
- Abnormalities in the genes that encode Large Amino Acid Transporters increase the risk of Autism Spectrum Disorder.
Cascio, Molecular genetics & genomic medicine 2020 - GeneRIF: Abnormalities in the genes that encode Large Amino Acid Transporters increase the risk of Autism Spectrum Disorder.
- The solute carrier SLC7A8 is a marker of favourable prognosis in ER-positive low proliferative invasive breast cancer.
El, Breast cancer research and treatment 2020 - GeneRIF: The solute carrier SLC7A8 is a marker of favourable prognosis in ER-positive low proliferative invasive breast cancer.
- Sub-Nanometer Cryo-EM Density Map of the Human Heterodimeric Amino Acid Transporter 4F2hc-LAT2.
Jeckelmann, International journal of molecular sciences 2020 - GeneRIF: Sub-Nanometer Cryo-EM Density Map of the Human Heterodimeric Amino Acid Transporter 4F2hc-LAT2.
- Small molecule inhibitors provide insights into the relevance of LAT1 and LAT2 in materno-foetal amino acid transport.
Zaugg, Journal of cellular and molecular medicine 2020 - GeneRIF: Small molecule inhibitors provide insights into the relevance of LAT1 and LAT2 in materno-foetal amino acid transport.
- More
SPy_2088 putative cationic amino acid transporter protein from Streptococcus pyogenes M1 GAS
22% identity, 59% coverage
YPTB1621 APC family aromatic amino acid transport protein from Yersinia pseudotuberculosis IP 32953
YPO1743 aromatic amino acid transport protein from Yersinia pestis CO92
19% identity, 57% coverage
- Growth of Yersinia pseudotuberculosis in human plasma: impacts on virulence and metabolic gene expression
Rosso, BMC microbiology 2008 - “...(pepN) YPO1414 putative aminopeptidase N 1.432 (0.041) YPTB1541 (ysuJ) YPO1529 putative decarboxylase 2.092 (< 0.001) YPTB1621 (aroP) YPO1743 aromatic amino acid transport protein 1.68 (0.006) YPTB1641 (hpaF) YPO1765 5-carboxymethyl-2-hydroxymuconate delta-isomerase 1.812 (0.015) YPTB1656 (ptrB) YPO1780 oligopeptidase B 1.695 (0.006) YPTB1889 (lysA) or1363 possible diaminopimelate decarboxylase 1.621...”
- Growth of Yersinia pseudotuberculosis in human plasma: impacts on virulence and metabolic gene expression
Rosso, BMC microbiology 2008 - “...putative aminopeptidase N 1.432 (0.041) YPTB1541 (ysuJ) YPO1529 putative decarboxylase 2.092 (< 0.001) YPTB1621 (aroP) YPO1743 aromatic amino acid transport protein 1.68 (0.006) YPTB1641 (hpaF) YPO1765 5-carboxymethyl-2-hydroxymuconate delta-isomerase 1.812 (0.015) YPTB1656 (ptrB) YPO1780 oligopeptidase B 1.695 (0.006) YPTB1889 (lysA) or1363 possible diaminopimelate decarboxylase 1.621 (0.01) 0.45...”
- Detecting non-orthology in the COGs database and other approaches grouping orthologs using genome-specific best hits
Dessimoz, Nucleic acids research 2006 - “...STM0150, 3: STM3930, 4: STM0400, 5: STM4398, 6: STM1584, 7: STM2793), Y.pestis (2a: YPO3421, 2b: YPO1743, 3: YPO3854, 4a: YPO3201, 4b: YPO4015, 5: YPO1859, 6: YPO1937). Table 1 Results of the algorithm on the COGs database # % Pairs with score below threshold, not tested 1021764...”
XOO1270 amino acid transporter from Xanthomonas oryzae pv. oryzae KACC10331
22% identity, 62% coverage
TC 2.A.3.1.8 / P40812 Asparagine permease (AnsP) of 497 aas and 12 TMSs from Salmonella typhimurium (see 2 papers)
ansP / AAA80001.1 L-asparagine permease from Salmonella enterica (see paper)
STM1584 APC family, L-asparagine transport protein from Salmonella typhimurium LT2
23% identity, 60% coverage
- substrates: Asparagine
- Detecting non-orthology in the COGs database and other approaches grouping orthologs using genome-specific best hits
Dessimoz, Nucleic acids research 2006 - “...PA2079), Salmonella typhimurium LT2 (1: STM0568, 2: STM0150, 3: STM3930, 4: STM0400, 5: STM4398, 6: STM1584, 7: STM2793), Y.pestis (2a: YPO3421, 2b: YPO1743, 3: YPO3854, 4a: YPO3201, 4b: YPO4015, 5: YPO1859, 6: YPO1937). Table 1 Results of the algorithm on the COGs database # % Pairs...”
YncF / b1453 L-asparagine transporter from Escherichia coli K-12 substr. MG1655 (see 2 papers)
ANSP_ECOLI / P77610 L-asparagine permease; L-asparagine transport protein from Escherichia coli (strain K12) (see paper)
TC 2.A.3.1.24 / P77610 Asparagine transporter of 499 aas and 12 TMSs, 91% identical to the orthologue in Salmonella enterica (2.A.3.1.8) from Escherichia coli (strain K12)
ECs2057 L-asparagine permease from Escherichia coli O157:H7 str. Sakai
b1453 L-asparagine permease from Escherichia coli str. K-12 substr. MG1655
23% identity, 60% coverage
- substrates: Asparagine
- Canonical Single Nucleotide Polymorphisms (SNPs) for High-Resolution Subtyping of Shiga-Toxin Producing Escherichia coli (STEC) O157:H7
Griffing, PloS one 2015 - “...[ 19 ] Reported in Humans ECs5049 5137547 No [ 19 ] Reported in Humans ECs2057 2041566 No [ 16 ] ECs3881 3885057 No [ 16 ] ECs4826 4891379 Cluster 1, Cluster 2 [ 16 ] 3798 No [ 17 ] 5234150 No [ 17 ]...”
- Detecting non-orthology in the COGs database and other approaches grouping orthologs using genome-specific best hits
Dessimoz, Nucleic acids research 2006 - “...7: ZgabP), E.coli H7 (1: ECs0614, 2: ECs0116, 3: ECs4729, 4: ECs0452, 5: ECs5186, 6: ECs2057, 7: ECs3524), P.aeruginosa (2a: PA3000, 2b: PA0866, 4a: PA5097, 4b: PA0789, 7: PA0129, out: PA2079), Salmonella typhimurium LT2 (1: STM0568, 2: STM0150, 3: STM3930, 4: STM0400, 5: STM4398, 6: STM1584,...”
- Extracellular loops matter - subcellular location and function of the lysine transporter Lyp1 from Saccharomyces cerevisiae
Van't, The FEBS journal 2020 - “...and for bacterial, P24207 , P37460 , P25737 , P15993 , P0AAE0 , P25527 , P77610 , P39137 , and P42087 corresponding to PheP, ProY, LysP, AroP, CycA, GabP, AnsP, RocE, and HutM, respectively. This resulted in a population of 450, 105, and 835 sequences for...”
- Trans-complementation by the RecB nuclease domain of RecBCD enzyme reveals new insight into RecA loading upon χ recognition
Pavankumar, Nucleic acids research 2024 - “...20 ). The following phage strains were also used in the study. 1081 ( susJ6 b1453 cI857 + D123 ), 1082 ( b1453 + D123 susR5 ), 1083 ( susJ6 b1453 + 76 cI857 ), 1084 ( b1453 + 76 susR5 ), T4 phage ( gene...”
- A flexible RecC surface loop required for Chi hotspot control of RecBCD enzyme
Amundsen, Genetics 2023 - “...to determine Chi hotspot activity. Vegetative crosses between susJ6 b1453 cI857 and b1453 cI+ susR5 had +D123 (between cI and R) in both parents in cross 1...”
- Chi hotspot control of RecBCD helicase-nuclease by long-range intramolecular signaling
Amundsen, Scientific reports 2020 - “...to clear plaques among selected J + R + phage from cross 1 ( susJ6 b1453 cI857 + D123 x b1453 + D123 susR5 ) or cross 2 ( susJ6 b1453 + 76 cI857 x b1453 + 76 susR5 ) 31 . Recombinant frequency for lambda...”
- RecBCD Enzyme "Chi Recognition" Mutants Recognize Chi Recombination Hotspots in the Right DNA Context
Amundsen, Genetics 2016 - “...and l 873 (x+76; i.e., containing Chi) phage; both contain b1453, which deletes red and most of gam. For large-scale screening, a 50 ml aliquot of each phage...”
- “...which x+F and x+G arose, are placed to scale. The b1453 deletion extends from bp 27,728-33,032; red (bp 31,348-32,810) with the red-3 mutation (T to A at bp...”
- McbR/YncC: implications for the mechanism of ligand and DNA binding by a bacterial GntR transcriptional regulator involved in biofilm formation
Lord, Biochemistry 2014 - “...Predicted iron outer membrane transporter yncE b1452 ATP-binding protein, periplasmic, function unknown yncF ansP , b1453 l -asparagine transporter yncG b1454 Glutathione S-transferase homologue yncH b1455 Conserved protein, function unknown Supporting Information Available CD spectra and EMSA of McbR variants (Figure S1). This material is available...”
- Involvement of Escherichia coli DNA Replication Proteins in Phage Lambda Red-Mediated Homologous Recombination
Poteete, PloS one 2013 - “...210 mutation is an amber mutation in the gam gene [15] , [16] . The b1453 deletion removes sequences from att through gam [28] . A simple deletion, red , removing sequences between the first three codons of red ( bet ) and the last three...”
- “...a partial Feb phenotype: red forms barely visible plaques at reduced efficiency, while 210 and b1453 (deleted for both red and gam ) make no plaques. The D424A mutation has no effect on plating; neither does the triple polymerase deletion polB dinB umuDC. The quadruple polymerase...”
- Genome of Enterobacteriophage Lula/phi80 and insights into its ability to spread in the laboratory environment
Rotman, Journal of bacteriology 2012 - “...methods. (i) Phage genotypes. Lambda-pal is MMS1632 pal571 cI857 b1453 Chi76. b1453 is a deletion spanning the int, xis, exo, bet, and gam genes (38). The...”
- “...107 107 1010 Palindrome phage, MMS1632 pal571 cI1857 b1453 k 76. Control phage DKC14 plated with equal efficiency in these experiments. phi80t, truncated phi80,...”
- Separation of the bacterial species, Escherichia coli, from mixed-species microbial communities for transcriptome analysis
Dai, BMC microbiology 2011 - “...peptidase proW b2678 2.4 1.1 3.3 1.3 -1.6 (-1.1, -2.3) Glycine betaine transporter subunit ansP b1453 2.2 1.1 2.5 1.1 1.2 (0.9, 1.48) L -asparagine transporter ydhB b1659 -2.2 1.1 -2.9 1.2 -5.0 (-4.4, -5.7) Predicted DNA-binding transcriptional regulator yhhN b3468 -2.6 1.3 -3.1 1.2 -3.1...”
- More
y2564 aromatic amino acid permease from Yersinia pestis KIM
19% identity, 57% coverage
7nf6B / A0A6P3EL78 Ovine b0,+at-rbat heterodimer (see paper)
22% identity, 59% coverage
- Ligands: cholesterol; 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (7nf6B)
SPRI_5940 ethanolamine permease from Streptomyces pristinaespiralis
24% identity, 61% coverage
- Initial Metabolic Step of a Novel Ethanolamine Utilization Pathway and Its Regulation in Streptomyces coelicolor M145
Krysenko, mBio 2019 - “...to the absence of a specific ethanolamine permease. Heterologous expression of a putative ethanolamine permease (SPRI_5940) from Streptomyces pristinaespiralis positively influenced the biomass accumulation of the overexpression strain grown in defined medium with ethanolamine. In this study, we demonstrated that a glutamine synthetase-like protein, GlnA4 (SCO1613),...”
- “...the M145 parental strain, glnA4 mutant, epuRI mutant, and putative ethanolamine permease overexpression strain M145pRM4 spri_5940 in defined Evans medium after 7days of incubation at 30C. Error bars indicate standard errors of results from n =3 biological replicates. The conserved ethanolamine permease gene is absent from...”
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The PaperBLAST database links 793,807 different protein sequences to 1,259,118 scientific articles. Searches against EuropePMC were last performed on March 13 2025.
PaperBLAST builds a database of protein sequences that are linked
to scientific articles. These links come from automated text searches
against the articles in EuropePMC
and from manually-curated information from GeneRIF, UniProtKB/Swiss-Prot,
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CharProtDB,
MetaCyc,
EcoCyc,
TCDB,
REBASE,
the Fitness Browser,
and a subset of the European Nucleotide Archive with the /experiment tag.
Given this database and a protein sequence query,
PaperBLAST uses protein-protein BLAST
to find similar sequences with E < 0.001.
To build the database, we query EuropePMC with locus tags, with RefSeq protein
identifiers, and with UniProt
accessions. We obtain the locus tags from RefSeq or from MicrobesOnline. We use
queries of the form "locus_tag AND genus_name" to try to ensure that
the paper is actually discussing that gene. Because EuropePMC indexes
most recent biomedical papers, even if they are not open access, some
of the links may be to papers that you cannot read or that our
computers cannot read. We query each of these identifiers that
appears in the open access part of EuropePMC, as well as every locus
tag that appears in the 500 most-referenced genomes, so that a gene
may appear in the PaperBLAST results even though none of the papers
that mention it are open access. We also incorporate text-mined links
from EuropePMC that link open access articles to UniProt or RefSeq
identifiers. (This yields some additional links because EuropePMC
uses different heuristics for their text mining than we do.)
For every article that mentions a locus tag, a RefSeq protein
identifier, or a UniProt accession, we try to select one or two
snippets of text that refer to the protein. If we cannot get access to
the full text, we try to select a snippet from the abstract, but
unfortunately, unique identifiers such as locus tags are rarely
provided in abstracts.
PaperBLAST also incorporates manually-curated protein functions:
- Proteins from NCBI's RefSeq are included if a
GeneRIF
entry links the gene to an article in
PubMed®.
GeneRIF also provides a short summary of the article's claim about the
protein, which is shown instead of a snippet.
- Proteins from Swiss-Prot (the curated part of UniProt)
are included if the curators
identified experimental evidence for the protein's function (evidence
code ECO:0000269). For these proteins, the fields of the Swiss-Prot entry that
describe the protein's function are shown (with bold headings).
- Proteins from BRENDA,
a curated database of enzymes, are included if they are linked to a paper in PubMed
and their full sequence is known.
- Every protein from the non-redundant subset of
BioLiP,
a database
of ligand-binding sites and catalytic residues in protein structures, is included. Since BioLiP itself
does not include descriptions of the proteins, those are taken from the
Protein Data Bank.
Descriptions from PDB rely on the original submitter of the
structure and cannot be updated by others, so they may be less reliable.
(For SitesBLAST and Sites on a Tree, we use a larger subset of BioLiP so that every
ligand is represented among a group of structures with similar sequences, but for
PaperBLAST, we use the non-redundant set provided by BioLiP.)
- Every protein from EcoCyc, a curated
database of the proteins in Escherichia coli K-12, is included, regardless
of whether they are characterized or not.
- Proteins from the MetaCyc metabolic pathway database
are included if they are linked to a paper in PubMed and their full sequence is known.
- Proteins from the Transport Classification Database (TCDB)
are included if they have known substrate(s), have reference(s),
and are not described as uncharacterized or putative.
(Some of the references are not visible on the PaperBLAST web site.)
- Every protein from CharProtDB,
a database of experimentally characterized protein annotations, is included.
- Proteins from the CAZy database of carbohydrate-active enzymes
are included if they are associated with an Enzyme Classification number.
Even though CAZy does not provide links from individual protein sequences to papers,
these should all be experimentally-characterized proteins.
- Proteins from the REBASE database
of restriction enzymes are included if they have known specificity.
- Every protein with an evidence-based reannotation (based on mutant phenotypes)
in the Fitness Browser is included.
- Sequence-specific transcription factors (including sigma factors and DNA-binding response regulators)
with experimentally-determined DNA binding sites from the
PRODORIC database of gene regulation in prokaryotes.
- Putative transcription factors from RegPrecise
that have manually-curated predictions for their binding sites. These predictions are based on
conserved putative regulatory sites across genomes that contain similar transcription factors,
so PaperBLAST clusters the TFs at 70% identity and retains just one member of each cluster.
- Coding sequence (CDS) features from the
European Nucleotide Archive (ENA)
are included if the /experiment tag is set (implying that there is experimental evidence for the annotation),
the nucleotide entry links to paper(s) in PubMed,
and the nucleotide entry is from the STD data class
(implying that these are targeted annotated sequences, not from shotgun sequencing).
Also, to filter out genes whose transcription or translation was detected, but whose function
was not studied, nucleotide entries or papers with more than 25 such proteins are excluded.
Descriptions from ENA rely on the original submitter of the
sequence and cannot be updated by others, so they may be less reliable.
Except for GeneRIF and ENA,
the curated entries include a short curated
description of the protein's function.
For entries from BioLiP, the protein's function may not be known beyond binding to the ligand.
Many of these entries also link to articles in PubMed.
For more information see the
PaperBLAST paper (mSystems 2017)
or the code.
You can download PaperBLAST's database here.
Changes to PaperBLAST since the paper was written:
- November 2023: incorporated PRODORIC and RegPrecise. Many PRODORIC entries were not linked to a protein sequence (no UniProt identifier), so we added this information.
- February 2023: BioLiP changed their download format. PaperBLAST now includes their non-redundant subset. SitesBLAST and Sites on a Tree use a larger non-redundant subset that ensures that every ligand is represented within each cluster. This should ensure that every binding site is represented.
- June 2022: incorporated some coding sequences from ENA with the /experiment tag.
- March 2022: incorporated BioLiP.
- April 2020: incorporated TCDB.
- April 2019: EuropePMC now returns table entries in their search results. This has expanded PaperBLAST's database, but most of the new entries are of low relevance, and the resulting snippets are often just lists of locus tags with annotations.
- February 2018: the alignment page reports the conservation of the hit's functional sites (if available from from Swiss-Prot or UniProt)
- January 2018: incorporated BRENDA.
- December 2017: incorporated MetaCyc, CharProtDB, CAZy, REBASE, and the reannotations from the Fitness Browser.
- September 2017: EuropePMC no longer returns some table entries in their search results. This has shrunk PaperBLAST's database, but has also reduced the number of low-relevance hits.
Many of these changes are described in Interactive tools for functional annotation of bacterial genomes.
PaperBLAST cannot provide snippets for many of the papers that are
published in non-open-access journals. This limitation applies even if
the paper is marked as "free" on the publisher's web site and is
available in PubmedCentral or EuropePMC. If a journal that you publish
in is marked as "secret," please consider publishing elsewhere.
Many important articles are missing from PaperBLAST, either because
the article's full text is not in EuropePMC (as for many older
articles), or because the paper does not mention a protein identifier such as a locus tag, or because of PaperBLAST's heuristics. If you notice an
article that characterizes a protein's function but is missing from
PaperBLAST, please notify the curators at UniProt
or add an entry to GeneRIF.
Entries in either of these databases will eventually be incorporated
into PaperBLAST. Note that to add an entry to UniProt, you will need
to find the UniProt identifier for the protein. If the protein is not
already in UniProt, you can ask them to create an entry. To add an
entry to GeneRIF, you will need an NCBI Gene identifier, but
unfortunately many prokaryotic proteins in RefSeq do not have
corresponding Gene identifers.
References
PaperBLAST: Text-mining papers for information about homologs.
M. N. Price and A. P. Arkin (2017). mSystems, 10.1128/mSystems.00039-17.
Europe PMC in 2017.
M. Levchenko et al (2017). Nucleic Acids Research, 10.1093/nar/gkx1005.
Gene indexing: characterization and analysis of NLM's GeneRIFs.
J. A. Mitchell et al (2003). AMIA Annu Symp Proc 2003:460-464.
UniProt: the universal protein knowledgebase.
The UniProt Consortium (2016). Nucleic Acids Research, 10.1093/nar/gkw1099.
BRENDA in 2017: new perspectives and new tools in BRENDA.
S. Placzek et al (2017). Nucleic Acids Research, 10.1093/nar/gkw952.
The EcoCyc database: reflecting new knowledge about Escherichia coli K-12.
I. M. Keeseler et al (2016). Nucleic Acids Research, 10.1093/nar/gkw1003.
The MetaCyc database of metabolic pathways and enzymes.
R. Caspi et al (2018). Nucleic Acids Research, 10.1093/nar/gkx935.
CharProtDB: a database of experimentally characterized protein annotations.
R. Madupu et al (2012). Nucleic Acids Research, 10.1093/nar/gkr1133.
The carbohydrate-active enzymes database (CAZy) in 2013.
V. Lombard et al (2014). Nucleic Acids Research, 10.1093/nar/gkt1178.
The Transporter Classification Database (TCDB): recent advances
M. H. Saier, Jr. et al (2016). Nucleic Acids Research, 10.1093/nar/gkv1103.
REBASE - a database for DNA restriction and modification: enzymes, genes and genomes.
R. J. Roberts et al (2015). Nucleic Acids Research, 10.1093/nar/gku1046.
Deep annotation of protein function across diverse bacteria from mutant phenotypes.
M. N. Price et al (2016). bioRxiv, 10.1101/072470.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory