PaperBLAST
PaperBLAST Hits for sp|Q032G9|DAPH_LACLS 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase OS=Lactococcus lactis subsp. cremoris (strain SK11) OX=272622 GN=dapH PE=3 SV=1 (257 a.a., MTQAQKLSAQ...)
Show query sequence
>sp|Q032G9|DAPH_LACLS 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase OS=Lactococcus lactis subsp. cremoris (strain SK11) OX=272622 GN=dapH PE=3 SV=1
MTQAQKLSAQEIIQFIGNAEKKTQVKVTLSGMPSFKSAGFLAENGRPNFKALANKGIQVL
GDFHTHYSLKIIIGDWQAVRPLLEGLTENKDYTIEFEGRNSAVPLLDTRAINARIEPGAI
IRDQVMIGDNAVIMMGAIINIGAEIGEGTMIDMGAVLGGRATVGKNSHIGAGAVLAGVIE
PASAEPVRVGDNVLVGANAVVIEGVQVGSGSVVAAGAIVTQDVPENVVVAGVPARTIKEI
DEKTAQKTALEDALRNL
Running BLASTp...
Found 250 similar proteins in the literature:
SPD_1923 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase, putative from Streptococcus pneumoniae D39
spr1907 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase-related protein from Streptococcus pneumoniae R6
73% identity, 99% coverage
- Dynamic Pneumococcal Genetic Adaptations Support Bacterial Growth and Inflammation during Coinfection with Influenza
Smith, Infection and immunity 2021 - “...protein SPD_1354 Conserved hypothetical protein SPD_1414 Oxalate:formate antiporter SPD_1468 Phosphoglycerate mutase SPD_1782 ksgA Dimethyladenosine transferase SPD_1923 2,3,4,5-Tetrahydropyridine-2-carboxylate N -succinyltransferase, putative SPD_2047 cbiO1 Cobalt ABC transporter, ATP-binding protein CbiO1 SPD_2048 cbiO2 Cobalt ABC transporter, ATP-binding protein CbiO2 Total 17 23 a Pneumococcal fitness genes identified at 12...”
- Inactivation of Transcriptional Regulator FabT Influences Colony Phase Variation of Streptococcus pneumoniae
Zhang, mBio 2021 - “...mutS DNA mismatch repair protein MutS 0.54 0.041 SPD_1922 hipO N -acetyldiaminopimelate deacetylase 0.59 0.043 SPD_1923 dapD 2,3,4,5-Tetrahydropyridine-2,6-dicarboxylate N -acetyltransferase 0.85 0.004 SPD_1926 tyrS Tyrosine-tRNA ligase 1.07 0.002 SPD_1927 ctpC Heavy metal translocating P-type ATPase 0.96 0.000 SPD_1931 Membrane protein 0.74 0.020 SPD_1984 ybbK Putative stomatin/prohibitin-family...”
- Redefining the Small Regulatory RNA Transcriptome in Streptococcus pneumoniae Serotype 2 Strain D39
Sinha, Journal of bacteriology 2019 - “...1873276-1873324 Spd_sr106b 1892400-1892550 () spd_1924, spd_1923 Spd_sr107 Spd_sr108b Spd_sr109b 1903127-1903247 () malP, spd_1931 1913211-1913442 () spd_1939,...”
- Reactive Oxygen Species Contribute to the Bactericidal Effects of the Fluoroquinolone Moxifloxacin in Streptococcus pneumoniae
Ferrándiz, Antimicrobial agents and chemotherapy 2016 - “...acid biosynthesis: Gln Amino acid biosynthesis: Ser spr1907 (dapD) spr0443c-0444 (glnRA) spr1095 (metY) spr0823 (but)d spr1324 (apbE)d spr0530 (fba) spr1902...”
SP_2097 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase, putative from Streptococcus pneumoniae TIGR4
72% identity, 99% coverage
A8AUL9 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase from Streptococcus gordonii (strain Challis / ATCC 35105 / BCRC 15272 / CH1 / DL1 / V288)
SGO_0158 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase, putative from Streptococcus gordonii str. Challis substr. CH1
69% identity, 99% coverage
- Intracellular Ser/Thr/Tyr phosphoproteome of the oral commensal Streptococcus gordonii DL1
Robertsson, BMC microbiology 2020 - “...dehydrogenase ald (SGO_0708) A8AW50 6.1/5.29 45,000/38960 1378 19 63% daph a) 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase dapH (SGO_0158) A8AUL9 5.2/5.06 22,000/24255 291 5 25% glya Serine hydroxymethyltransferase glyA, (SGO_1151) A8AXC8 5.4/5.07 48,000/45566 583 8 28% sed Homoserine dehydrogenase hom (SGO_0801) A8AWE0 5.0/4.86 45,000/46154 245 3 11% Nucleotide metabolism adk...”
- Intracellular Ser/Thr/Tyr phosphoproteome of the oral commensal Streptococcus gordonii DL1
Robertsson, BMC microbiology 2020 - “...Alanine dehydrogenase ald (SGO_0708) A8AW50 6.1/5.29 45,000/38960 1378 19 63% daph a) 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase dapH (SGO_0158) A8AUL9 5.2/5.06 22,000/24255 291 5 25% glya Serine hydroxymethyltransferase glyA, (SGO_1151) A8AXC8 5.4/5.07 48,000/45566 583 8 28% sed Homoserine dehydrogenase hom (SGO_0801) A8AWE0 5.0/4.86 45,000/46154 245 3 11% Nucleotide metabolism...”
Lreu_0613 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase from Limosilactobacillus reuteri subsp. reuteri
Lreu_0613 tetrahydrodipicolinate succinyltransferase domain-containing protein from Lactobacillus reuteri DSM 20016
60% identity, 98% coverage
- In Silico Genomic and Metabolic Atlas of Limosilactobacillus reuteri DSM 20016: An Insight into Human Health
Smythe, Microorganisms 2022 - “...connections can be made. While reviewing this pathway through UniProt, it was noted that gene Lreu_0613 was labeled as 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase in the KEGG database but as 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase in the UniProt database. The almost identical strain L. reuteri JCM 1112 had an identical amino acid...”
- Effect of amino acid availability on vitamin B12 production in Lactobacillus reuteri
Santos, Applied and environmental microbiology 2009 - “...lreu_0445 lreu_0502 lreu_0610 lreu_0611 lreu_0612 lreu_0613 lreu_1553 lreu_1791 lreu_1792 Succinyl-diaminopimelate desuccinylase (EC 3.5.1.18) Cystathionine...”
UC7_RS12340 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase from Enterococcus caccae ATCC BAA-1240
60% identity, 98% coverage
- Apigenin Impacts the Growth of the Gut Microbiota and Alters the Gene Expression of Enterococcus
Wang, Molecules (Basel, Switzerland) 2017 - “...Unknown UC7_RS13115 N -acetylmuramoyl- l -alanine amidase 1.7 Cell separation UC7_RS16345 hypothetical protein 1.7 Unknown UC7_RS12340 2_3_4_5-tetrahydropyridine-2_6-dicarboxylate N -acetyltransferase 1.7 Lysine biosynthesis UC7_RS13365 NrdR family transcriptional regulator 1.7 DNA synthesis and repair UC7_RS14530 molecular chaperone GroEL 1.7 Protein folding UC7_RS14300 GNAT family acetyltransferase 1.6 Transcriptional regulation...”
lmo1011 similar to tetrahydrodipicolinate succinylase from Listeria monocytogenes EGD-e
57% identity, 98% coverage
- In vivo transcriptional profiling of Listeria monocytogenes and mutagenesis identify new virulence factors involved in infection
Camejo, PLoS pathogens 2009 - “...amino acids of the aspartate and glutamate families ( ansB , lmo0594 , lmo1006 , lmo1011 , lmo2413 and glnA , lmo2770 , respectively), was also increased in vivo ( Table S8 ). Significantly, mannose ( lmo0781lmo0784 ), maltose ( lmo0278 ) and cellobiose ( lmo0301...”
- Genome-wide analyses reveal lineage specific contributions of positive selection and recombination to the evolution of Listeria monocytogenes
Orsi, BMC evolutionary biology 2008 - “..., lmo0028 , lmo2175 , lmo2348 , lmo2566 , lmo0487 , lmo0878 , lmo1004 , lmo1011 , and cbiH ) for evidence of recombination and to determine the recipient strains in the recombination events that were identified. Due to computational constraints, testing larger number of genes...”
- “...), lmo0028 , lmo2175 , lmo2348 , lmo2566 , lmo0487 , lmo0878 , lmo1004 , lmo1011 , cbiH ( lmo1199 ). "x" indicate substitutions inferred to have occurred in the respective branches. Red lines represent the probability for each nucleotide to have been imported by means...”
- Identification of sigma factor sigma B-controlled genes and their impact on acid stress, high hydrostatic pressure, and freeze survival in Listeria monocytogenes EGD-e
Wemekamp-Kamphuis, Applied and environmental microbiology 2004 - “...34.4 30.4 27.9 36.2 21.6 16.9 FbaA Hpr Lmo1704 Lmo1011 5.1 4.5 5.8 4.7 30.0 9.4 14.4 24.8 ThiD Lmo1580 Similar to fructose-1,6-biphosphate aldolase PTS...”
- Development of a Listeria monocytogenes EGDe partial proteome reference map and comparison with the protein profiles of food isolates
Ramnath, Applied and environmental microbiology 2003 - “...MreB (lmo1548), similar to cell shape-determining protein lmo1011, similar to tetrahydrodipicolinate succinylase LmaA (lmo0118), antigen A lmo0273, similar to...”
NP_833700 Tetrahydrodipicolinate N-acetyltransferase from Bacillus cereus ATCC 14579
BC_3981, BG08_1843 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase from Bacillus cereus ATCC 14579
57% identity, 98% coverage
- Proteomic evidences for rex regulation of metabolism in toxin-producing Bacillus cereus ATCC 14579
Laouami, PloS one 2014 - “...0,185 - BC_0015 NP_829919 Pyridoxine biosynthesis protein N N 1,8 0,01 3,6 0,00 - BC_3981 NP_833700 tetrahydrodipicolinate -acetyltransferase N N ND ND 3,3 0,00 MoaB BC_4758 NP_834462 Molybdenum cofactor N N 0,94 0,187 2,3 0,02 FrvB BC_4571 NP_834277 Deblocking aminopeptidase N N 3,2 0,00 0,92 0,215...”
- Tandem Mass Tag-Based Quantitative Proteomics and Virulence Phenotype of Hemolymph-Treated Bacillus thuringiensis kurstaki Cells Reveal New Insights on Bacterial Pathogenesis in Insects
Sun, Microbiology spectrum 2021 - “...OppA: oligopeptide ABC transporter (oligopeptide-binding protein) ( Listeria monocytogenes 4b str. F2365) VFG006783 1E125 A0A242XDX9 BG08_1843 Lpg0754: acetyltransferase (LPS) ( Legionella pneumophila Philadelphia 1) VFG045302 3E06 A0A0F6FTK0 BG08_3740 VipF: hypothetical protein (type IVB secretion effectors) ( Legionella pneumophila str. Lens) VFG010772 4E25 A0A2T7YRG6 C5676_02345 NarK2: nitrate/nitrite...”
- Proteomic evidences for rex regulation of metabolism in toxin-producing Bacillus cereus ATCC 14579
Laouami, PloS one 2014 - “...1,06 0,185 - BC_0015 NP_829919 Pyridoxine biosynthesis protein N N 1,8 0,01 3,6 0,00 - BC_3981 NP_833700 tetrahydrodipicolinate -acetyltransferase N N ND ND 3,3 0,00 MoaB BC_4758 NP_834462 Molybdenum cofactor N N 0,94 0,187 2,3 0,02 FrvB BC_4571 NP_834277 Deblocking aminopeptidase N N 3,2 0,00 0,92...”
GBAA4194 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase, putative from Bacillus anthracis str. 'Ames Ancestor'
BA4194 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase, putative from Bacillus anthracis str. Ames
57% identity, 98% coverage
- Modulation of the Bacillus anthracis secretome by the immune inhibitor A1 protease
Pflughoeft, Journal of bacteriology 2014 - “...47504496 47504630 47504637 GBAA3845 GBAA3962 GBAA3964 GBAA4055 GBAA4187 GBAA4194 NC NC 48 47504637 GBAA4194 16 47504830 GBAA4387 NC GBAA identificationc 8 92 6...”
- Identification of the immunogenic spore and vegetative proteins of Bacillus anthracis vaccine strain A16R
Liu, PloS one 2013 - “...hydratase 28746 5.66 New r008 - BA4839 citZ Citrate synthase 41928 5.36 New r003 - BA4194 - 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase 25745 5.42 New Note: a :Molecular Weight b :Isoelectric Point Cellular function analysis of the immunogenic proteins Fig. 2 shows the cellular functions of the identified immunogenic...”
- Activation of the latent PlcR regulon in Bacillus anthracis
Sastalla, Microbiology (Reading, England) 2010 - “...dehydrogenase C 49.5 5.0 BA4184 Pyruvate dehydrogenase complex E1 component, alpha subunit C 41.4 5.6 BA4194 Putative 2,3,4,5-tetrahydropyridine-2-carboxylate N -succinyltransferase C 25.7 5.2 BA4499 Superoxide dismutase, Mn E 22.7 5.3 BA5130 Phosphoglucose isomerase C 50.3 4.8 BA5364 Enolase C 46.4 4.4 BA5470 Sulfatase MA 73.5 6.4...”
MW1285 tetrahydrodipicolinate acetyltransferase from Staphylococcus aureus subsp. aureus MW2
Q7A2S0 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase from Staphylococcus aureus (strain Mu50 / ATCC 700699)
SA1229 tetrahydrodipicolinate acetyltransferase from Staphylococcus aureus subsp. aureus N315
SAV1397 tetrahydrodipicolinate acetyltransferase from Staphylococcus aureus subsp. aureus Mu50
SAUSA300_1290 tetrahydrodipicolinate acetyltransferase from Staphylococcus aureus subsp. aureus USA300_FPR3757
SACOL1432 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase from Staphylococcus aureus subsp. aureus COL
E5491_RS07270, SAPIG1398, USA300HOU_RS07115 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase from Staphylococcus aureus subsp. aureus ST398
52% identity, 98% coverage
- The SaeR/S gene regulatory system is essential for innate immune evasion by Staphylococcus aureus
Voyich, The Journal of infectious diseases 2009 - “...A 2.25 ES MW1283 dapA dihydrodipicolinate synthase 2.37 ES MW1284 dapB dihydrodipicolinate reductase 2.28 ES MW1285 dapD tetrahydrodipicolinate acetyltransferase 2.15 ES MW1286 - hippurate hydrolase 2.24 ES MW1517 glyS glycyl-tRNA synthetase 2.08 ES MW1721 - transaldolase 2.01 ES MW1842 - glutamyl-tRNAGln amidotransferase subunit C 2.43 ES...”
- Genetic and metabolic signatures of Salmonella enterica subsp. enterica associated with animal sources at the pangenomic scale
Vila, BMC genomics 2019 - “...IlvY 4,116,897 c.317C>A p.Leu106Gln P0A2Q2 Fish Gene 2.310 8 dapH 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase N/A N/A N/A Q7A2S0 Fish Gene 3.310 3 cgkA Kappa-carrageenase N/A N/A N/A P43478 Metabolic pathways mainly impacted by mutations associated with animal sources (i.e. GOEA) Based on the mutations associatedby microbial GWAS (Table...”
- “...Q7CPA1 SNP in aspA GO:0008797 aspartate ammonia-lyase activity 1 0.01 6 110 7 MF fish Q7A2S0 gene dapH GO:0047200 tetrahydrodipicolinate N-acetyltransferase activity 1 0.01 8 110 7 MF fish P43478 gene cgkA GO:0033918 kappa-carrageenase activity 1 0.01 6 110 7 MF Discussion Restricted and unrestricted animal...”
- Characterizing the effects of inorganic acid and alkaline shock on the Staphylococcus aureus transcriptome and messenger RNA turnover
Anderson, FEMS immunology and medical microbiology 2010 - “...6.0 2.5 ND sarZ SA2384 staphylococcal accessory protein Z sa_c1214s994_a_at * 5.8 2.5 15 sun SA1229 Sun protein sa_c10502s10951cv_s_at * 2.8 2.5 2.5 tcaR SA2353 transcriptional regulator sa_c791s594_at * 8.1 2.5 stable SA1107 transcriptional regulator sa_c3623s3103_a_at * 8.7 2.5 2.5 SA1904 putative transcriptional regulator sa_c446s279_a_at *...”
- “...* 7.7 2.5 ND sarY SA2289 staphylococcal accessory regulator sa_c1214s994_a_at * 7.5 2.5 2.5 sun SA1229 Sun protein sa_c10502s10951cv_s_at 3.6 2.5 2.5 tcaR SA2353 transcriptional regulator sa_c3928s3395_a_at 2.2 2.5 ND SA0179 phosphosugar-binding transcriptional regulator sa_c7020s6143_a_at 2.9 2.5 ND SA0404 transcriptional regulator sa_c7120s6232_a_at 3.4 2.5 ND SA0432...”
- Transcriptional signature following inhibition of early-stage cell wall biosynthesis in Staphylococcus aureus
O'Neill, Antimicrobial agents and chemotherapy 2009 - “...SA1163 SA1164 SA1165 SA1166 SA1170 SA1226 SA1227 SA1228 SA1229 SA1230 SA1231 SA1235 SA1236 SA1238 SA1254 SA1255 SA1256 SA1257 SA1532 SA1545 SA1546 SA1691 SA1858...”
- Microarray analysis of toxicogenomic effects of ortho-phenylphenol in Staphylococcus aureus
Jang, BMC genomics 2008 - “...Decisively SA1225 ( lys C)-SA1226 ( asd )-SA1227 ( dap A)-SA1228 ( dap B) and SA1229 ( dap D) show fold highest decreases as -54.6, -21.5, -27.3, -31.4, and -23.5 folds at 20 min and -7.7, -4.3, -5.2, -5.1, and -4.4 folds at 60 min in...”
- “...CTT GGG TCA GTG GCA TAC ACA-3' 5'-TGG GTG CAA CAG GAT TAG TAG GCA-3' SA1229 -23.5 -4.4 -7.4( 2.0) -1.2( 0.2) 5'-TGG GTG CAA CAG GAT TAG TAG GCA-3' 5'-TTC AAC TTC TTG CCC TGC AGA ACG-3' SA2093 6.8 9.0 15.7( 1.2) 4.6( 0.5) 5'-TTC...”
- Characterization of the oxygen-responsive NreABC regulon of Staphylococcus aureus
Schlag, Journal of bacteriology 2008 - “...Berkeley Downregulated genes SA0691 SA1225 SA1226 SA1227 SA1228 SA1229 SA1759 SA2176 SA2183 SA2184 SA2185 SA2186 SA2187 SA2188 SA2189 SA2384 Gene name VOL. 190,...”
- Studies on the mechanism of telavancin decreased susceptibility in a laboratory-derived mutant
Song, Microbial drug resistance (Larchmont, N.Y.) 2013 - “...SAV1330 thrB homoserine kinase homolog SAV1397 dapD tetrahydrodipicolinate acetyltransferase SAV0012 NA putative homoserineo-acetyltransferase Subcategory Fold...”
- Further insights into the mode of action of the lipoglycopeptide telavancin through global gene expression studies
Song, Antimicrobial agents and chemotherapy 2012 - “...Locus ID Amino acid biosynthesis SAV1328 SAV1395 SAV1396 SAV1397 SAV1394 SACOL1364 SAV1329 Song et al. 3162 aac.asm.org bacitracin (48), and the cationic...”
- Transposon sequencing identifies genes impacting Staphylococcus aureus invasion in a human macrophage model
Lo, Infection and immunity 2023 (secret) - In vitro and in vivo models of Staphylococcus aureus endophthalmitis implicate specific nutrients in ocular infection
Sadaka, PloS one 2014 - “...dehydrogenase 14.2 (1.4) SACOL1430 dapA Dihydrodipicolinate synthase 13.5 (1.2) SACOL1431 dapB Dihydrodipicolinate reductase 14.4 (1.2) SACOL1432 dapD 2,3,4,5-tetrahydropyridine-2,6-dicarboxylateN-succinyltransferase 13.0 (1.1) ig_SACOL1432-3 Intergenic region between dapD andSACOL1433 26.4 (1.8) SACOL1433 M20/M25/M40 family peptidase 9.2 (1.3) SACOL1434 Alanine racemase 9.2 (1.2) SACOL1449 sucA 2-oxoglutarate dehydrogenase E1 component 5.2...”
- Investigations into sigmaB-modulated regulatory pathways governing extracellular virulence determinant production in Staphylococcus aureus
Shaw, Journal of bacteriology 2006 - “...same insertion site was found for each of the SACOL1432 (ykuQ), SACOL1433 (hipO), and SACOL1441 (telA) clones, suggesting that these were likely to be siblings....”
- “...of California, Berkeley SACOL0482 SACOL1006 SACOL1428 SACOL1432 SACOL1433 SACOL1435 SACOL1438 SACOL1439 SACOL1441 SACOL1443 SACOL1445 SACOL1947 SACOL2057 a VOL....”
- New Insights into the Biological Functions of Essential TsaB/YeaZ Protein in Staphylococcus aureus
Guo, Antibiotics (Basel, Switzerland) 2024 - “...E5491_RS04085 9 3 down-down thrB E5491_RS06900 6 0 down-down leuC E5491_RS11545 5 0 down-down dapH E5491_RS07270 4 0 down-down tsaB/yeaZ E5491_RS11500 4 groEL E5491_RS11380 4 2 down-down yidC E5491_RS11755 4 13 up-up ilvA E5491_RS11555 4 0 down-down dapB E5491_RS07265 3 0 down-down metE E5491_RS01730 3 3...”
- High-Throughput Mutagenesis Reveals a Role for Antimicrobial Resistance- and Virulence-Associated Mobile Genetic Elements in Staphylococcus aureus Host Adaptation
Ba, Microbiology spectrum 2023 - “...Hypothetical protein S Pig 1384832-1385536 SAPIG2159 prmC Modification methylase hemk family protein J Pig 2235773-2236606 SAPIG1398 dapH_3 2,3,4,5-Tetrahydropyridine-2,6-dicarboxylate N -acetyltransferase E Pig 1472561-1473280 SAPIG1387 pstB Phosphate ABC superfamily ATP-binding cassette transporter, ABC protein P Pig 1460322-1461173 SAPIG0966 DNA segregation ATPase ftsk/spoIIIE D Pig 1013337-1014722 SAPIG1366 Prephenate...”
- Absence of Protoheme IX Farnesyltransferase CtaB Causes Virulence Attenuation but Enhances Pigment Production and Persister Survival in MRSA
Xu, Frontiers in microbiology 2016 - “...1.91E-02 Dihydrodipicolinate reductase USA300HOU_RS13735 1.82 1.46E-02 Transcriptional regulator USA300HOU_RS08760 rplU 1.79 1.10E-02 Ribosomal protein L21 USA300HOU_RS07115 dapD 1.75 2.17E-02 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase USA300HOU_RS07100 asd 1.74 2.52E-02 Aspartate-semialdehyde dehydrogenase USA300HOU_RS06985 trpB 1.72 4.42E-02 Tryptophan synthase beta subunit USA300HOU_RS06055 pyrE 1.71 2.74E-02 Orotate phosphoribosyltransferase USA300HOU_RS06045 carB 1.68 1.67E-02 Carbamoyl-phosphate...”
NWMN_1308 tetrahydrodipicolinate acetyltransferase from Staphylococcus aureus subsp. aureus str. Newman
51% identity, 98% coverage
- Comparative Transcriptome Analysis Reveals Differentially Expressed Genes Related to Antimicrobial Properties of Lysostaphin in Staphylococcus aureus
Yan, Antibiotics (Basel, Switzerland) 2022 - “...Table 2 presents the 15 InDels identified in mutant 1801_2010 compared to Newman_WT. Two genes (NWMN_1308 and NWMN_1410) contained 5 InDels . The remaining 10 InDels were distributed in 5 important intergenic regions: 4 of them were in the intergenic region between the NWMN_0810 and NWMN_0811...”
- “...Insertion Intergenic region (between NWMN_0810 and NWMN_0811) DNAseq mutant reads 1,441,311 ACCC ACC 1 Deletion NWMN_1308 ( dapD ) :tetrahydrodipicolinate acetyltransferase 1,440,676 1,441,395 DNAseq mutant reads 1,441,331 CA CAA 1 Insertion NWMN_1308 ( dapD ) :tetrahydrodipicolinate acetyltransferase 1,440,676 1,441,395 DNAseq mutant reads 1,578,835 GAAA GAA 1...”
- Structure-guided microbial targeting of antistaphylococcal prodrugs
Miller, eLife 2021 - “...PCR Primer TGGGACGAAGTAATTACAGTT Sequence-based reagent NWMN_1192 (pgsA) _R This paper PCR Primer ATATCCCCCTTGTATCGTTT Sequence-based reagent NWMN_1308 (dapD) _F This paper PCR Primer TCTATTCGTGGAGGTACGAT Sequence-based reagent NWMN_1308 (dapD) _R This paper PCR Primer ATCGTATGTGAGCCATTACC Sequence-based reagent NWMN_1410_F This paper PCR Primer CGATAAACCTAAACCACTCG Sequence-based reagent NWMN_1410_R This paper...”
- CodY in Staphylococcus aureus: a regulatory link between metabolism and virulence gene expression
Pohl, Journal of bacteriology 2009 - “...NWMN_1284 NWMN_1304 NWMN_1305 NWMN_1306 NWMN_1307 NWMN_1308 NWMN_1311 NWMN_1348 NWMN_1616 NWMN_1617 NWMN_1749 NWMN_1750 NWMN_1960 NWMN_1961 NWMN_1962 NWMN_1963...”
CAC2381 Tetrahydrodipicolinate N-succinyltransferase from Clostridium acetobutylicum ATCC 824
50% identity, 95% coverage
- Genome-scale model for Clostridium acetobutylicum: Part I. Metabolic network resolution and analysis
Senger, Biotechnology and bioengineering 2008 - “...CAC3171, CAC1479. List 3: CAC3169/CAC3176/ CAC3652, CAC0091, CAC3170/CAC3604, CAC1479, CAC3038. List 4: CAC0998, CAC2378/CAC3600, CAC2379, CAC2381, CAC2380, CAC2723, CAC2624, CAC0608. List 5: CAC1825, CAC0390, CAC0391, CAC3348/CAC0578. List 6: CAC0737/CAC1001/CAC1819/CAC2832/CAC0764/CAC1673/CAC1674. List 7: (from DAHP) CAC0894, CAC0713/CAC0899, CAC0897, CAC0898, CAC0895, CAC0896. List 8: CAC2680, CAC0944, CAC1348, CAC1730, CAC0726,...”
DAPH_BACSU / O34981 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Tetrahydrodipicolinate N-acetyltransferase; THP acetyltransferase; Tetrahydropicolinate acetylase; EC 2.3.1.89 from Bacillus subtilis (strain 168) (see 2 papers)
BSU14180 tetrahydrodipicolinate N-acetyltransferase from Bacillus subtilis subsp. subtilis str. 168
55% identity, 98% coverage
Clocel_1978 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase from Clostridium cellulovorans 743B
51% identity, 95% coverage
- Clostridium cellulovorans Proteomic Responses to Butanol Stress
Costa, Frontiers in microbiology 2021 - “...biosynthesis of a number of amino acids including proline and arginine (Clocel_2734, Clocel_3150, Clocel_1668), lysine (Clocel_1978, Clocel_3115), methionine (Clocel_1764, Clocel_2896, Clocel_3040), and branched chain amino acids (BCAA) (Clocel_1324, Clocel_1325, Clocel_0493) ( Table 1 and Supplementary Table 2 ). In addition, up-regulated proteins include four aminotransferases (Clocel_1948,...”
TEL01S_RS10080 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase from Pseudothermotoga elfii DSM 9442 = NBRC 107921
52% identity, 97% coverage
- Adaptation Strategies to High Hydrostatic Pressures in Pseudothermotoga species Revealed by Transcriptional Analyses
Fenouil, Microorganisms 2023 - “...threonine, and lysine. In addition, genes dapA , B , and D (TEL01S_RS00130, TEL01S_RS03640, and TEL01S_RS10080), which are involved in lysine biosynthesis, were over-expressed at 30 MPa ( Figure 4 , Table 1 ), while genes metB , metH , mtnK , and mtnA (TEL01S_RS05650, TEL01S_RS06970,...”
- “...1 TEL01S_RS00130 dapA ko00300:Lysine biosynthesis 0 1 0 TEL01S_RS09220 murF ko00300:Lysine biosynthesis 0 1 0 TEL01S_RS10080 dapD ko00300:Lysine biosynthesis|ko01230:Biosynthesis of amino acids 0 1 0 TEL01S_RS08600 kdd ko00310:Lysine degradation 0 1 0 TEL01S_RS05490 amiE ko00330:Arginine and proline metabolism|ko00360:Phenylalanine metabolism|ko00380:Tryptophan metabolism 0 0 1 TEL01S_RS06380 hisC ko00340:Histidine...”
CD3227 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase from Clostridium difficile 630
50% identity, 97% coverage
- Global transcriptional control by glucose and carbon regulator CcpA in Clostridium difficile
Antunes, Nucleic acids research 2012 - “...dapA2 (CD3223), dihydrodipicolinate synthase 2; dapA3 (CD3225), dihydrodipicolinate synthase 3; dapB1 (CD3226), dihydrodipicolinate reductase; dapH (CD3227), 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate; lysA (CD2053), diaminopimelate decarboxylase; thrC (CD2118), threonine synthase, thrB (CD2119), homoserine kinase; tdcB (CD2514), threonine dehydratase II; serA (CD0995), putative D-3-phosphoglycerate dehydrogenase; sdaB (CD3222), L-serine dehydratase; cysE (CD1595), serine...”
3r8yA / Q81MQ2 Structure of the bacillus anthracis tetrahydropicolinate succinyltransferase
58% identity, 86% coverage
- Ligand: calcium ion (3r8yA)
ECH_0058 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase from Ehrlichia chaffeensis str. Arkansas
37% identity, 54% coverage
- Impact of Three Different Mutations in Ehrlichia chaffeensis in Altering the Global Gene Expression Patterns
Kondethimmanahalli, Scientific reports 2018 - “...were also among the downregulated genes. Metabolic enzymes involved in biosynthetic processes, {tetrahydropyridine-2-carboxylate N-succinyltransferasem (dapD) (ECH_0058), quinone oxidoreductase (ECH_0385), metalloendopeptidase, (MEP) (ECH_0644), peptide deformylase (PDF) (ECH_0939), serine/threonine phosphatase (PSP) (ECH_0964), pyrophosphatase (PPi) (ECH_1014), and orotate phosphoribosyltransferase (OPRTase) (ECH_1108)}, were also down-regulated. Transcription- and translation-related genes, such...”
- “...gene expression (RPKM) Fold change (ECH_0490/wildtype) FDR 0.001, p-value <0.05 Gene name Down regulated genes ECH_0058 1902 1006 1.88 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase ECH_0085 1119 523 2.17 ABC transporter, ATP-binding protein ECH_0095 1921 990 1.96 protein-export membrane protein SecF ECH_0264 814 310 5.55 conserved hypothetical protein ECH_0298 8295...”
XF0114 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase from Xylella fastidiosa 9a5c
35% identity, 59% coverage
- Analysis of the biofilm proteome of Xylella fastidiosa
Silva, Proteome science 2011 - “...5.27 404 I.D XF1427 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein [Xylella fastidiosa 9a5c] 44116 5.47 104 II.A.1 XF0114 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase [Xylella fastidiosa 9a5c] 32566 6.0 136 II.A.2 XF1822 ketol-acid reductoisomerase [Xylella fastidiosa 9a5c] 40369 6.17 127 II.A.2 XF1821 acetolactate synthase 2 catalytic subunit [Xylella fastidiosa 9a5c] 62856 5.77...”
RC0243 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase from Rickettsia conorii str. Malish 7
39% identity, 52% coverage
- Deciphering <i>Rickettsia conorii</i> metabolic pathways: A treasure map to therapeutic targets
Prajapat, Biotechnology notes (Amsterdam, Netherlands) 2025 - “...kinase catalyses the first step in the biosynthesis of Lys,met, and ser Metabolism Cytoplasm No RC0243 DapD_Trfase_Hexpep_rpt_fam Metabolise aspartic acid to produce four amino acids -lysine, threonine, methionine and isoleucine, bacterial cell wall biosynthesis Metabolism Cytoplasm Yes RC0579 DAP_epimerase_DapF Bacterial cell wall biosynthesis, and dipicolinic acid...”
A8GMH0 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase from Rickettsia akari (strain Hartford)
39% identity, 52% coverage
P45284 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
HI1634 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase from Haemophilus influenzae Rd KW20
35% identity, 52% coverage
- Characterization of a bordetella pertussis diaminopimelate (DAP) biosynthesis locus identifies dapC, a novel gene coding for an N-succinyl-L,L-DAP aminotransferase
Fuchs, Journal of bacteriology 2000 - “...accession number P41396), H. influenzae (GenBank accession number P45284), and E. coli (GenBank accession number K02970) to the product of ORF2 (DapD B....”
- Interrogation of Essentiality in the Reconstructed Haemophilus influenzae Metabolic Network Identifies Lipid Metabolism Antimicrobial Targets: Preclinical Evaluation of a FabH β-Ketoacyl-ACP Synthase Inhibitor
López-López, mSystems 2022 - “...ddl ) d -Alanine- d -alanine ligase 1.17.1.8 HI1308 ( dapB ) 4-hydroxy-tetrahydrodipicolinate reductase 2.3.1.117 HI1634 ( dapD ) 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase 5.1.1.3 HI1739.2 ( murI ) Glutamate racemase Amino acids metabolism Phenylalanine, tyrosine, and tryptophan 4.2.3.5 HI0196 ( aroC ) Chorismate synthase 2.7.1.71 HI0207 ( aroK...”
DNO_0817 2,3,4,5-tetrahydropyridine-2-carboxylate N- succinyltransferase from Dichelobacter nodosus VCS1703A
35% identity, 61% coverage
P41396 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase from Actinobacillus pleuropneumoniae
34% identity, 53% coverage
Q5GSI7 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase from Wolbachia sp. subsp. Brugia malayi (strain TRS)
37% identity, 52% coverage
SAMCFNEI73_Ch0442 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase from Sinorhizobium americanum
34% identity, 50% coverage
SMc01732 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase from Sinorhizobium meliloti 1021
34% identity, 48% coverage
Dshi_0006 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase from Dinoroseobacter shibae DFL 12
33% identity, 52% coverage
- Dinoroseobacter shibae Outer Membrane Vesicles Are Enriched for the Chromosome Dimer Resolution Site dif
Wang, mSystems 2021 - “...5.55E03 5.35E04 0.56 Dshi_2705 Uroporphyrinogen decarboxylase Intracellular protein Porphyrin and related pathway 5.51E03 8.56E04 0.55 Dshi_0006 2,3,4,5-Tetrahydropyridine-2,6-dicarboxylate N -succinyltransferase Intracellular protein Amino acid metabolism 5.34E03 5.62E04 0.53 Dshi_0950 Ribosomal 5S rRNA E-loop binding protein Intracellular protein Translation 5.30E03 1.12E03 0.53 Dshi_3571 Chaperone protein DnaK Intracellular protein...”
P31852 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase (EC 2.3.1.117) from Pseudomonas amygdali pv. tabaci (see paper)
41% identity, 52% coverage
EAM_0816 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase from Erwinia amylovora ATCC 49946
34% identity, 53% coverage
BAB2_0991 Bacterial transferase hexapeptide repeat:2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase from Brucella melitensis biovar Abortus 2308
32% identity, 64% coverage
NMB0335 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase from Neisseria meningitidis MC58
33% identity, 53% coverage
PMI2288 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase from Proteus mirabilis HI4320
PMI_RS11300 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase from Proteus mirabilis HI4320
33% identity, 53% coverage
NGO1667 DapD from Neisseria gonorrhoeae FA 1090
33% identity, 53% coverage
- Global Network Analysis of Neisseria gonorrhoeae Identifies Coordination between Pathways, Processes, and Regulators Expressed during Human Infection
McClure, mSystems 2020 - “...was enriched for amino acid metabolism processes and included genes such NGO1541 ( murE ), NGO1667 ( dapD ), and NGO1808. Module 10 was strongly enriched for genes involved in genetic information processing such as translation and transcription and included genes encoding several ribosomal proteins and...”
- Manganese regulation of virulence factors and oxidative stress resistance in Neisseria gonorrhoeae
Wu, Journal of proteomics 2010 - “...B 20939 NGO1454 lysyl-tRNA synthetase (LysRS) lysS B 57370 NGO0799 inosine-5-monophosphate dehydrogenase imdH F 52429 NGO1667 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase, DapD dapD G 29291 NGO1238 ATP phosphoribosyltransferase hisG G 26232 NGO1134 GTP cyclohydrolase II gch2 H 22098 NGO1310 guanylate kinase / GMP kinase Gmk/kguA F 23412 NGO1668 glucose-6-phosphate...”
FTN_1727 tetrahydrodipicolinate succinylase subunit from Francisella tularensis subsp. novicida U112
41% identity, 43% coverage
- Structural and functional analysis of the Francisella lysine decarboxylase as a key actor in oxidative stress resistance
Felix, Scientific reports 2021 - “...1 ). Consistent with the lack of LdcF in the deletion mutant, the 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase (FTN_1727, DapD) involved in lysine biosynthesis was found to be downregulated. Surprisingly, although all proteins encoded by the FPI (FTN_1309 to FTN_1326) 5 were detected in the MS-based quantitative proteomic assay...”
- “...1.255628185 0.000806353 FTN_1272 Proton-dependent oligopeptide transporter (POT) family protein, di- or tripeptide:H+symporter 1.243209089 1.20616E05 dapD FTN_1727 2,3,4,5-tetrahydropyridine-2,6-carboxylate N -succinyltransferase 1.185622324 0.000977552 FTN_1258 Hypothetical protein 1.11437438 0.000177817 hsdM FTN_1152 Type I restriction-modification system, subunit M (methyltransferase) 1.098834276 0.000436818 FTN_1316 Hypothetical protein 1.075883638 0.005337719 FTN_1628 LysR family transcriptional...”
HD0630 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase from Haemophilus ducreyi 35000HP
35% identity, 53% coverage
Echvi_3551 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase from Echinicola vietnamensis DSM 17526
34% identity, 53% coverage
- GapMind: Automated Annotation of Amino Acid Biosynthesis
Price, mSystems 2020 - “...not required for growth Novel Lysine: DapCE or DapL Echinicola vietnamensis KMM 6221, DSM 17526 Echvi_3551 is a good candidate for the succinyltransferase DapD, which suggests succinylated intermediates, but DapC and DapE are missing, or Echvi_0124 might be a diverged diaminopimelate aminotransferase (DapL) Novel Lysine: DapE...”
dapD / CAA08875.1 DapD from Bordetella pertussis (see paper)
32% identity, 52% coverage
BCAL2101 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase from Burkholderia cenocepacia J2315
34% identity, 52% coverage
THC0290_1081 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase from Flavobacterium psychrophilum
40% identity, 39% coverage
- More Than Gliding: Involvement of GldD and GldG in the Virulence of Flavobacterium psychrophilum
Pérez-Pascual, Frontiers in microbiology 2017 - “...of unknown function precursor containing a C-terminal secretion signal. Putative adhesin. TIGR04131 12.67 12.67 1.00 THC0290_1081 dapD 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferas 7.00 7.00 1.00 THC0290_0973 lpdA1 Dihydrolipoyl dehydrogenase 7.00 4.67 0.67 THC0290_0743 gldN Gliding motility protein precursor GldN 6.80 11.33 1.67 THC0290_0754 Protein of unknown function precursor, putative...”
BPSL2169 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase from Burkholderia pseudomallei K96243
35% identity, 52% coverage
- Altered Proteome of Burkholderia pseudomallei Colony Variants Induced by Exposure to Human Lung Epithelial Cells
Al-Maleki, PloS one 2015 - “...10 2 37.99/37.89 6.1/6.17 141 - Cytoplasmic 2.94 0.01 23 2,3,4,5 tetrahydropyridine -2,6-carboxylate N-succinyltransferase (DapD) BPSL2169 19 5 29.52/29.48 5.68/5.66 371 - Cytoplasmic 2.03 0.05 C. Carbohydrate Transport and Metabolism 17 Fructose-bisphosphate aldolase (CbbA) BPSL0798 17 6 38.49/38.31 5.97/5.87 361 - Cytoplasmic 2.70 0.006 6 Glyceraldehyde...”
- “...(ArgT) BPSS0269 53 13 28.32/28.33 8.61/8.61 1127 + Periplasmic 3.56 0.01 23 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase (DapD) BPSL2169 19 5 29.52/29.38 5.68/5.66 371 - Cytoplasmic 3.13 0.0007 D. Carbohydrate Transport and Metabolism 2 Enolase: phosphopyruvate hydratase (Eno) BPSL2270 31 13 45.65/45.55 4.81/4.81 1187 - Cytoplasmic 2.58 0.02 E....”
- Proteomic analysis of colony morphology variants of Burkholderia pseudomallei defines a role for the arginine deiminase system in bacterial survival
Chantratita, Journal of proteomics 2012 - “...conversion of betaine aldehyde to glycine betaine Amino acid transport and metabolism/ 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase 74 BPSL2169 29,660 5.68 181 0.136 0.386 Cytoplasmic Catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway Inorganic ion transport and metabolism Sulfurtransferase 49 sseA BPSS1766 31,119...”
lpg0754 acetyltransferase from Legionella pneumophila subsp. pneumophila str. Philadelphia 1
37% identity, 54% coverage
- Small Regulatory RNA and Legionella pneumophila
Faucher, Frontiers in microbiology 2011 - “...lpr0021 744637 744929 292 lpg0691 Weissenmayer et al. ( 2011 ) lpr0025 825408 825265 143 lpg0754 Weissenmayer et al. ( 2011 ) lpr0026 837669 837871 202 lpg0766 Weissenmayer et al. ( 2011 ) lpr0028 871501 871409 92 lpg0796 Weissenmayer et al. ( 2011 ) lpr0029 1046275...”
- Identification of Legionella pneumophila-specific genes by genomic subtractive hybridization with Legionella micdadei and identification of lpnE, a gene required for efficient host cell entry
Newton, Infection and immunity 2006 - “...E10/2B5 2E6 2C12 G7 C3, B5 D12, E12 yvf, lpg0754, waaM, lpg0774 LPS and lipidA biosynthesis lpg2699 lepB lpg2222 ladC lpg2977, lpg1176 pleD, lpg1357 Autolysin...”
- “...and B11, representing neighboring orf21 (lyrF) and orf22 (lpg0754), were L. pneumophila specific. This piece of data is consistent with a recent hybridization...”
YPTB3006 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase from Yersinia pseudotuberculosis IP 32953
35% identity, 53% coverage
- Growth of Yersinia pseudotuberculosis in human plasma: impacts on virulence and metabolic gene expression
Rosso, BMC microbiology 2008 - “...(proX) YPO2645 glycine betaine-binding periplasmic protein 0.637 (0.009) YPTB2986 YPO1061 conserved hypothetical protein 0.551 (0.031) YPTB3006 (dapD) YPO1041 2.3.4.5-tetrahydropyridine-2-carboxylate N-succinyltransferase 0.398 (< 0.001) 1.445 (0.005) YPTB3181 (gcsH) YPO0906 glycine cleavage system H protein 0.377 (< 0.001) YPTB3182 (gcvT) YPO0907 aminomethyltransferase 0.526 (0.022) YPTB3189 (serA) YPO0914 D-3-phosphoglycerate...”
y3140 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase from Yersinia pestis KIM
Q8ZH69 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase from Yersinia pestis
YPO1041 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase from Yersinia pestis CO92
35% identity, 53% coverage
- Deletion of Yersinia pestis ail Causes Temperature-Sensitive Pleiotropic Effects, Including Cell Lysis, That Are Suppressed by Carbon Source, Cations, or Loss of Phospholipase A Activity
Kolodziejek, Journal of bacteriology 2021 - “...protein Chaperones 3 18.2 y3165 ptr Protease III precursor Degradation of proteins, peptides 3 5.2 y3140 dapD 2, 3, 4, 5-Tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase Amino acid biosynthesis: lysine 3 13.5 y2629 gnd 6-Phosphogluconate dehydrogenase Energy metabolism, carbon: oxidative branch, pentose pathway 3 9.5 y1990 tpx Thiol peroxidase Protection...”
- Investigation of Yersinia pestis Laboratory Adaptation through a Combined Genomics and Proteomics Approach
Leiser, PloS one 2015 - “...Periplasmic solute-binding protein Q7CFN1 4.91/5.55 10.23/17.83 asnB/YPO2623 Asparagine synthetase Q7CJU5 0.37/NI 0.49/NI dapD/YPO1041 Tetrahydropicolinate succinylase Q8ZH69 2.87/2.76 2.04/2.04 dapE/YPO3053 Succinyl-diaminopimelate desuccinylase Q7CJI9 AO/NI AO/AO gcvP/YPO0905 Glycine dehydrogenase Q8ZHI8 2.15/2.08 NI/NI gcvT/YPO0907 Aminomethyltransferase Q8ZHI6 2.09/NI NI/NI gdhA/YPO3971 Glutamate dehydrogenase Q0WA46 11.47/NI 104.63/94.65 glnA/YPO0024 Glutamine synthetase Q74YC3 5.90/NI...”
- Growth of Yersinia pseudotuberculosis in human plasma: impacts on virulence and metabolic gene expression
Rosso, BMC microbiology 2008 - “...glycine betaine-binding periplasmic protein 0.637 (0.009) YPTB2986 YPO1061 conserved hypothetical protein 0.551 (0.031) YPTB3006 (dapD) YPO1041 2.3.4.5-tetrahydropyridine-2-carboxylate N-succinyltransferase 0.398 (< 0.001) 1.445 (0.005) YPTB3181 (gcsH) YPO0906 glycine cleavage system H protein 0.377 (< 0.001) YPTB3182 (gcvT) YPO0907 aminomethyltransferase 0.526 (0.022) YPTB3189 (serA) YPO0914 D-3-phosphoglycerate dehydrogenase 1.582...”
c0201 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase from Escherichia coli CFT073
30% identity, 53% coverage
Ssa / b0166 tetrahydrodipicolinate succinylase (EC 2.3.1.117) from Escherichia coli K-12 substr. MG1655 (see 10 papers)
dapD / P0A9D8 tetrahydrodipicolinate succinylase (EC 2.3.1.117) from Escherichia coli (strain K12) (see 9 papers)
DAPD_ECOLI / P0A9D8 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Succinyl-CoA: tetrahydrodipicolinate N-succinyltransferase; Tetrahydrodipicolinate N-succinyltransferase; THDP succinyltransferase; THP succinyltransferase; Tetrahydropicolinate succinylase; EC 2.3.1.117 from Escherichia coli (strain K12) (see paper)
dapD / MB|P0A9D8 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase from Escherichia coli K12 (see paper)
NP_414708 tetrahydrodipicolinate succinylase from Escherichia coli str. K-12 substr. MG1655
b0166 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase from Escherichia coli str. K-12 substr. MG1655
30% identity, 53% coverage
- function: Catalyzes the formation of N-succinyl-2-amino-6-oxo-L- pimelate from succinyl-CoA and tetrahydrodipicolinate, a key step in lysine biosynthesis via diaminopimelate pathway.
catalytic activity: (S)-2,3,4,5-tetrahydrodipicolinate + succinyl-CoA + H2O = (S)- 2-succinylamino-6-oxoheptanedioate + CoA (RHEA:17325)
subunit: Was originally thought to be a homodimer, but is rather a homotrimer as shown in orthologs. - Acquisition of resistance to carbapenems in multidrug-resistant clinical strains of Acinetobacter baumannii: natural insertional inactivation of a gene encoding a member of a novel family of beta-barrel outer membrane proteins
Mussi, Antimicrobial agents and chemotherapy 2005 - “...valuea CarO ORF1 ORF2 247 236 273 AY684798 ZP_00145817 NP_414708 4e80 1e101 ORF3 ORF4 ORF5 307 353 232c NP_840656 ZP_00023858 ZP_00029254 1e104 1e105 1e82 a b c...”
- Two-dimensional gel electrophoresis of Escherichia coli homogenates: the Escherichia coli SWISS-2DPAGE database.
Pasquali, Electrophoresis 1996 (PubMed)- GeneRIF: N-terminus verified by Edman degradation on complete protein
- Open Issues for Protein Function Assignment in Haloferax volcanii and Other Halophilic Archaea
Pfeiffer, Genes 2021 - “...dapB yes 33% b0031 P04036 [ 140 ] 7893644 2a HVO_1099 dapD yes 32% b0166 P0A9D8 [ 141 ] 6365916 2a HVO_1096 dapE yes 29% b2472 P0AED7 [ 142 ] 3276674 function supported by gene clustering 2a HVO_1097 dapF yes 35% b3809 P0A6K1 [ 143 ]...”
- Identification of enzymes and regulatory proteins in Escherichia coli that are oxidized under nitrogen, carbon, or phosphate starvation
Noda, Proceedings of the National Academy of Sciences of the United States of America 2007 - “...P0A953 Q8FCU4 Q8FB98 P10408 P0AFG8 P0A8L2 P0AGD4 P0A837 P0A9D8 P00934 P27302 P59587 Protein name Protein MW Protein PI Aconitate hydratase 2 (citrate hydrolyase...”
- The Escherichia coli proteome: past, present, and future prospects
Han, Microbiology and molecular biology reviews : MMBR 2006 - “...(5-6) 5.33/31,023 (5-6) DapD P0A9D8 2,3,4,5-Tetrahydropyridine-2,6dicarboxylate Nsuccinyltransferase 5.56/29,892.10 5.51/31,680 5.49/32,476 (DIGE 4.5-6.5) DapF...”
- Open Issues for Protein Function Assignment in Haloferax volcanii and Other Halophilic Archaea
Pfeiffer, Genes 2021 - “...HVO_1100 dapB yes 33% b0031 P04036 [ 140 ] 7893644 2a HVO_1099 dapD yes 32% b0166 P0A9D8 [ 141 ] 6365916 2a HVO_1096 dapE yes 29% b2472 P0AED7 [ 142 ] 3276674 function supported by gene clustering 2a HVO_1097 dapF yes 35% b3809 P0A6K1 [ 143...”
- Reconstitution of the Mycobacterium tuberculosis pupylation pathway in Escherichia coli
Cerda-Maira, EMBO reports 2011 (secret) - Genome-scale analysis to the impact of gene deletion on the metabolism of E. coli: constraint-based simulation approach
Xu, BMC bioinformatics 2009 - “...b0096 b0004 b0052, b0103, b0109 b0072 b0086 b0179 b0031 b0131, b0133, b0134 b0073 b0087 b0181 b0166 b0142, b0154, b0159 b0074 b0088 b0182 b2472 b0173, b0174, b0369 b3770 b0090 b0524 b2478 b0414, b0415, b0417 b3771 b0091 b0914 b2838 b0420, b0421, b0423 b3774 b0954 b0915 b3359 b0475, b0750,...”
Q8X8Y7 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase (EC 2.3.1.117) from Escherichia coli (see paper)
Z0176 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase from Escherichia coli O157:H7 EDL933
ECs0168 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase from Escherichia coli O157:H7 str. Sakai
30% identity, 53% coverage
DAPD_UNKP / P56220 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Tetrahydrodipicolinate N-succinyltransferase; THDP succinyltransferase; THP succinyltransferase; Tetrahydropicolinate succinylase; EC 2.3.1.117 from Unknown prokaryotic organism (see paper)
1kgqA / P56220 Crystal structure of tetrahydrodipicolinate n-succinyltransferase in complex with l-2-aminopimelate and succinamide-coa (see paper)
30% identity, 53% coverage
- catalytic activity: (S)-2,3,4,5-tetrahydrodipicolinate + succinyl-CoA + H2O = (S)- 2-succinylamino-6-oxoheptanedioate + CoA (RHEA:17325)
subunit: Homotrimer. - Ligands: (2s)-2-aminoheptanedioic acid; succinamide-coa (1kgqA)
B5Y1K5 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase from Klebsiella pneumoniae (strain 342)
30% identity, 53% coverage
- Antibacterial Activities of Phenolic Compounds in Miang Extract: Growth Inhibition and Change in Protein Expression of Extensively Drug-Resistant Klebsiella pneumoniae
Anek, Antibiotics (Basel, Switzerland) 2024 - “...B5Y277 deoC Deoxyribose-phosphate aldolase 2-deoxy-D-ribose 1-phosphate formation from Gly-3P and acetaldehyde. Down (5.8262) Amino-acid biosynthesis B5Y1K5 dapD 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase L-lysine biosynthesis via the DAP pathway. Down (5.0427) A6T4E3 thrB Homoserine kinase L-threonine biosynthesis; L-threonine from L-aspartate. Down (5.0516) Q9F0P1 mtnK Methylthioribose kinase L-methionine biosynthesis via the...”
- Lavender essential oil induces oxidative stress which modifies the bacterial membrane permeability of carbapenemase producing Klebsiella pneumoniae
Yang, Scientific reports 2020 - “...Membrane 3.66352 7 Uridine phosphorylase udp P52671 Nucleotide metabolism Cytoplasm 3.41065 8 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase dapD B5Y1K5 Cell wall biosyntheiss Cytoplasm 3.27497 9 Elongation factor Ts tsf A6T4X2 Protein biosynthesis Cytoplasm 3.19873 10 MethioninetRNA ligase metG A6TBK7 Protein biosynthesis Cytoplasm 2.92754 11 Carbapenem-hydrolyzing beta-lactamase KPC bla Q9F663...”
STM0213 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase from Salmonella typhimurium LT2
30% identity, 53% coverage
STY0236 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase from Salmonella enterica subsp. enterica serovar Typhi str. CT18
Q8Z9A8 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase from Salmonella typhi
30% identity, 53% coverage
- Immunoaffinity-based mass spectrometric characterization of immunoreactive proteins of Salmonella Typhi
Safi, Saudi journal of biological sciences 2023 - “...ADP- l - glycero - d - manno -heptose-6-epimerase X Amino acid biosynthesis Q8Z9A8 dapD STY0236 2,3,4,5-Tetrahydropyridine-2,6-dicarboxylate X X Q8Z381 ilvC STY3648 Ketol acid reductoisomerase X Q8Z123 argI STY4807 Ornithine carbamoyltransferase X X Cofactors biosynthesis P66039 ribH STY0456 6,7-Dimethyl-8-ribityllumazine synthase X P0A2E2 glyA STY2802 Serine hydroxymethyltransferase...”
- Characterization of anti-Salmonella enterica serotype Typhi antibody responses in bacteremic Bangladeshi patients by an immunoaffinity proteomics-based technology
Charles, Clinical and vaccine immunology : CVI 2010 - “...WrbA MetE IlvC ArgI STY0236 STY1155 STY3594 STY3648 STY4807 2,3,4,5-Tetrahydropyridine-2,6-dicarboxylate Flavoprotein WrbA...”
- Immunoaffinity-based mass spectrometric characterization of immunoreactive proteins of Salmonella Typhi
Safi, Saudi journal of biological sciences 2023 - “...hldD STY4085 ADP- l - glycero - d - manno -heptose-6-epimerase X Amino acid biosynthesis Q8Z9A8 dapD STY0236 2,3,4,5-Tetrahydropyridine-2,6-dicarboxylate X X Q8Z381 ilvC STY3648 Ketol acid reductoisomerase X Q8Z123 argI STY4807 Ornithine carbamoyltransferase X X Cofactors biosynthesis P66039 ribH STY0456 6,7-Dimethyl-8-ribityllumazine synthase X P0A2E2 glyA STY2802...”
- Characterization of anti-Salmonella enterica serotype Typhi antibody responses in bacteremic Bangladeshi patients by an immunoaffinity proteomics-based technology
Charles, Clinical and vaccine immunology : CVI 2010 - “...X X X X X Amino acid biosynthesis Q8Z9A8 Q8Z7N9 Q8Z3B6 Q8Z381 Q8Z123 DapD WrbA MetE IlvC ArgI STY0236 STY1155 STY3594 STY3648 STY4807...”
c0457 Galactoside O-acetyltransferase from Escherichia coli CFT073
31% identity, 61% coverage
HVO_1099 23,4, 5-tetrahydropyridine-2-carboxylateN-succinyl transferase from Haloferax volcanii DS2
30% identity, 48% coverage
ECs0395 thiogalactoside acetyltransferase from Escherichia coli O157:H7 str. Sakai
30% identity, 64% coverage
BF4300 putative maltose O-acetyltransferase from Bacteroides fragilis YCH46
35% identity, 42% coverage
- Characterization of the O-Glycoproteome of Porphyromonas gingivalis
Veith, Microbiology spectrum 2022 - “...65% Cov Tanf_01290 GtfI BF4301 51% ID ND Tanf_01260 GtfM ND Tanf_01245 GtfS ND - BF4300 ND 25% ID, 56% Cov 27% ID, 46% Cov BF4299 ND a Dashes represent no significant hits. Shading represents highly significant matches over the full length of the protein. ID,...”
- Phylum-wide general protein O-glycosylation system of the Bacteroidetes
Coyne, Molecular microbiology 2013 - “...this GT adds the next monosaccharide of the outer glycan. As BF0522 from BF4301 and BF4300 are similarly sized, these GTs may each add a different monosaccharide to the same sugar, one as a side chain. Indeed, structural analysis of the wild type glycan did not...”
- “...( Coyne et al. , 2011 ). Cloning of LFG region genes for complementation studies BF4300, BF4301, BF4305, and BF4306 were PCR amplified using the primers indicated in Table S4 . The PCR products were digested with Bam HI and cloned into the BamH I site...”
A5I8H6 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase from Aeromonas salmonicida subsp. salmonicida
34% identity, 52% coverage
Msp_0450 predicted serine acetyltransferase from Methanosphaera stadtmanae DSM 3091
35% identity, 46% coverage
SAT4_ARATH / Q8W2B8 Serine acetyltransferase 4; AtSAT-4; AtSERAT3;2; EC 2.3.1.30 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Q8W2B8 serine O-acetyltransferase (EC 2.3.1.30) from Arabidopsis thaliana (see paper)
AT4G35640 ATSERAT3;2 (Serine acetyltransferase 3;2); acetyltransferase/ serine O-acetyltransferase from Arabidopsis thaliana
NP_195289 serine acetyltransferase 3;2 from Arabidopsis thaliana
34% identity, 35% coverage
- catalytic activity: L-serine + acetyl-CoA = O-acetyl-L-serine + CoA (RHEA:24560)
subunit: Homomultimer. - Mapping the Influence of Light Intensity on the Transgenerational Genetic Architecture of Arabidopsis thaliana
Mei, Current issues in molecular biology 2024 - “...stress response. AT4G35890 , AT4G36590, and AT4G36650 are related to transcriptional regulation, and AT4G35650 , AT4G35640, and AT4G36090 are related to anabolism. The genes duplicated under low light also included AT1G16440 and AT2G27520 , which are related to developmental regulation; AT1G16670 , AT2G27580, and AT2G28060, which...”
- “...4 T/T synonymous Plant-specific TFIIB-related protein Anabolism AT4G35650 16910021 4 T/T 3_prime_UTR Isocitrate dehydrogenase III AT4G35640 16911160 4 A/A upstream_gene Serine acetyltransferase 3;2 AT4G36090 17079871 4 T/T synonymous Oxidoreductase, 2OG-Fe(II) oxygenase family protein AT4G36250 17151190 4 A/A synonymous Aldehyde dehydrogenase 3F1 AT4G36360 17183722 4 T/T upstream_gene...”
- Identification of QTNs, QTN-by-environment interactions, and their candidate genes for salt tolerance related traits in soybean
Chen, BMC plant biology 2024 - “...Glyma13g33590 AT1G53580 GLY3 glyoxalase II 3 FWR Gm16:26,218,707 16 26,218,707 26.1218 2.9313 1.42E-23 SIG Glyma16g22630 AT4G35640 SERAT3;2 serine acetyltransferase 3;2 DWR the dry weights of roots, FWR the fresh weights of roots, LR the length of main root, LH the length of hypocotyls, Chr chromosome, Pos...”
- New insights into the regulation of plant metabolism by O-acetylserine: sulfate and beyond
Apodiakou, Journal of experimental botany 2023 - “...which are localized in plastids and mitochondria, respectively, and SERAT1;1 (AT5G56760), SERAT3;1 (AT2G17640), and SERAT3;2 (AT4G35640), which are localized and expressed in the cytosol ( Watanabe et al. , 2008 ; Krueger et al. , 2009 ). When plants experience reduced sulfate levels, OAS accumulates concomitant...”
- “..., 2008 ) ChaC-like/GGCT2;1 AT5G26220 7 Sulfur metabolism, glutathione process Paulose et al. (2013) SERAT3;2 AT4G35640 4 Sulfur metabolism, cysteine Kawashima et al. (2005) SDI1 AT5G48850 16 Sulfur metabolism, carbon metabolism, transcription Maruyama-Nakashita et al. (2005) SHM7 AT1G36370 12 Sulfur metabolism, carbon metabolism, methionine process Huang...”
- Impact of the SnRK1 protein kinase on sucrose homeostasis and the transcriptome during the diel cycle
Peixoto, Plant physiology 2021 - “...GGCT2;1 GAMMA-GLUTAMYL CYCLOTRANSFERASE 2;1 UP (leaves) 2.21 AT3G08860 PYD4 PYRIMIDINE 4 UP (leaves) 2.69 3.21 AT4G35640 SERAT3;2 SERINE ACETYLTRANSFERASE 3;2 UP (leaves) 1.04 AT4G31330 Putative transmembrne protein (DUF599) UP (leaves) 1.21 AT1G12030 Putative phosphoenolpyruvate carboxylase (DUF506) UP (leaves) 4.78 3.88 AT5G37260 RVE2 REVEILLE 2 DOWN (roots)...”
- Chemical Priming by Isothiocyanates Protects Against Intoxication by Products of the Mustard Oil Bomb
Ferber, Frontiers in plant science 2020 - “...family: SERAT1;1 (At5g56760, SAT-c), SERAT2;1 (At1g55920, SAT-p), SERAT2;2 (At3g13110, SAT-m), SERAT3;1 (At2g17640, SAT-106) and SERAT3;2 (At4g35640). Except for SERAT2;1 which was found to be induced by 1.6-fold by SF 4 h after treatment, none of these genes appeared to be regulated by SF in our microarray...”
- Cytokinin at the Crossroads of Abiotic Stress Signalling Pathways
Pavlů, International journal of molecular sciences 2018 - “...[ 178 ] APR3 AT4G21990 5-adenylylsulfate reductase 3 0/1 [ 178 , 180 ] SAT4 AT4G35640 Serine acetyltransferase 4 [ 181 , 182 ] BGLU28 AT2G44460 Beta-glucosidase 28 [ 179 , 180 ] BGLU30 AT3G60140 Beta-glucosidase 30 [ 180 , 182 ] SDI1 AT5G48850 Protein SULFUR...”
- Analysis of Promoters of Arabidopsis thaliana Divergent Gene Pair SERAT3;2 and IDH-III Shows SERAT3;2 Promoter is Nested Within the IDH-III Promoter
Raipuria, Molecular biotechnology 2017 (PubMed)- “...arranged gene pair SERAT3;2 and IDH-III encoded by At4g35640 and At4g35650 genes, respectively. As per TAIR annotation, these two genes are separated by a...”
- “...the IGR separating the divergent gene pair At4g35640 and At4g35650 coding, respectively, for Serine acetyl transferase (SERAT3;2) and isocitrate dehydrogenase...”
- Allyl-isothiocyanate treatment induces a complex transcriptional reprogramming including heat stress, oxidative stress and plant defence responses in Arabidopsis thaliana
Kissen, BMC genomics 2016 - “...Of these five genes, the ones encoding the plastidic SERAT2.1 (At1g55920) and the cytosolic SERAT3.2 (At4g35640) isoforms were induced by ITC, the former being upregulated at an earlier time point and the latter to a higher extent. Consistent with the downregulation of GSL biosynthetic genes discussed...”
- More
- Analysis of Promoters of Arabidopsis thaliana Divergent Gene Pair SERAT3;2 and IDH-III Shows SERAT3;2 Promoter is Nested Within the IDH-III Promoter.
Raipuria, Molecular biotechnology 2017 (PubMed)- GeneRIF: Study has identified a unique bidirectional promoter capable of driving gene expression in Arabidopsis thaliana, and showed for the first time, that SERAT3;2 promoter is nested in the IDH-III promoter.
- Comparative genomics and reverse genetics analysis reveal indispensable functions of the serine acetyltransferase gene family in Arabidopsis.
Watanabe, The Plant cell 2008 - GeneRIF: SERAT3;2 may play a major role during seed development.
- In silico assessment of gene function involved in cysteine biosynthesis in Arabidopsis: expression analysis of multiple isoforms of serine acetyltransferase.
Noji, Amino acids 2006 (PubMed)- GeneRIF: From the results of sensitivity to feedback regulation, subcellular localization and expression of mRNA analyses, each serine acetyltransferase (SATase) isoform seems to have its specific role for cysteine biosynthesis.
mru_0455 acetyltransferase from Methanobrevibacter ruminantium M1
35% identity, 53% coverage
1kruA / P07464 Galactoside acetyltransferase in complex with iptg and coenzyme a (see paper)
29% identity, 64% coverage
- Ligands: coenzyme a; 1-methylethyl 1-thio-beta-d-galactopyranoside (1kruA)
Tmz1t_3784 transferase hexapeptide repeat containing protein from Thauera sp. MZ1T
33% identity, 51% coverage
B0W47_13090 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase from Komagataeibacter nataicola
33% identity, 49% coverage
LacA / b0342 galactoside O-acetyltransferase (EC 2.3.1.18) from Escherichia coli K-12 substr. MG1655 (see 2 papers)
lacA / P07464 galactoside O-acetyltransferase (EC 2.3.1.18) from Escherichia coli (strain K12) (see 19 papers)
THGA_ECOLI / P07464 Galactoside O-acetyltransferase; GAT; Acetyl-CoA:galactoside 6-O-acetyltransferase; Thiogalactoside acetyltransferase; Thiogalactoside transacetylase; EC 2.3.1.18 from Escherichia coli (strain K12) (see 5 papers)
P07464 galactoside O-acetyltransferase (EC 2.3.1.18) from Escherichia coli (see paper)
NP_414876 galactoside O-acetyltransferase from Escherichia coli str. K-12 substr. MG1655
b0342 galactoside O-acetyltransferase from Escherichia coli str. K-12 substr. MG1655
29% identity, 64% coverage
- function: Catalyzes the CoA-dependent transfer of an acetyl group to the 6-O-methyl position of a range of galactosides, glucosides, and lactosides (PubMed:14009486, PubMed:4630409, PubMed:7592843). May assist cellular detoxification by acetylating non-metabolizable pyranosides, thereby preventing their reentry into the cell (Probable).
catalytic activity: a beta-D-galactoside + acetyl-CoA = a 6-acetyl-beta-D- galactoside + CoA (RHEA:15713)
subunit: Homotrimer. - The amino acid sequence of thiogalactoside transacetylase of Escherichia coli.
Fowler, Biochimie 1985 (PubMed)- GeneRIF: N-terminus verified by Edman degradation on complete protein
- Quantitative Shotgun Proteomic Analysis of Bacteria after Overexpression of Recombinant Spider Miniature Spidroin, MaSp1
Randene, International journal of molecular sciences 2024 - “...and lactose metabolism. Gene Protein Acc. # FCR p -Value Function lacA Galactoside O-acetyltransferase * P07464 +OLR 7.89 10 19 Lactose metabolism lacZ Beta-galactosidase * P00722 +OLR +270.33 1.00 10 20 Lactose metabolism N/A MaSp1 NTD-2x-CTD N/A +OLR +12.09 1.00 10 20 Target protein ybgl GTP...”
- “...= fold-change ratio. Gene Protein Acc. # p -Value FCR Function lacA Galactoside O-acetyltransferase * P07464 1.03 10 14 +OLR Lactose metabolism qorB Quinone oxidoreductase 2 P39315 8.38 10 4 +OLR Electron transport in respiratory chain cnoX Chaperedoxin P77395 8.38 10 4 +OLR Protein deaggregation dadX...”
- A Continuous Assay Set to Screen and Characterize Novel Protein N-Acetyltransferases Unveils Rice General Control Non-repressible 5-Related N-Acetyltransferase2 Activity
Asensio, Frontiers in plant science 2022 - “...bring unambiguous answer through the PDH-coupled assay. The sequence was derived from galactoside O-acetyltransferase (THGA, P07464). We could verify that the derived N-terminal decapeptide was indeed a substrate of OsGNAT2 with catalytic efficiency similar to the other decapeptides ( Table 2 ). We reported that plastid...”
- Identification of a Novel Therapeutic Target against XDR Salmonella Typhi H58 Using Genomics Driven Approach Followed Up by Natural Products Virtual Screening
Jalal, Microorganisms 2021 - “...1 Colanic acid biosynthesis acetyltransferase Serine acetyltransferase Q0WKM4 DB02078 Serine acetyltransferase P43886 DB01992 Galactoside o-acetyltransferase P07464 DB01862 2 Shikimate dehydrogenase Shikimate dehydrogenase P15770 DB03461; DB04447 Shikimate dehydrogenase P43876 DB02363 3 Pantoate-beta-alanine ligase Pantothenate synthetase Q5SHF5 DB03570 Pantothenate synthetase P0A5R0 DB01930; DB02596 4 Multidrug efflux RND transporter...”
- Analysis of a capsular polysaccharide biosynthesis locus of Bacteroides fragilis
Comstock, Infection and immunity 1999 - “...3-362) 1-364) 10-100) 10-236) D55213 P55254 S23343 P37745 P07464 P39856 G47677 S23344 U46859 AB004860 Q46634 U46859 U73857 U73857 A47677 Q48457 X85787 AF004325...”
- A workflow for annotating the knowledge gaps in metabolic reconstructions using known and hypothetical reactions
Vayena, Proceedings of the National Academy of Sciences of the United States of America 2022 - “...alternative pathway to compensate for the knockout of argG (b3172). The second added gene, LacA (b0342), encodes the enzyme galactoside O-acetyltransferase, which catalyzes the transfer of an acetyl group from acetyl-CoA to the 6-hydroxyl of some galactopyranosides ( 27 ). This enzyme is known to act...”
- Physiological studies of Escherichia coli strain MG1655: growth defects and apparent cross-regulation of gene expression
Soupene, Journal of bacteriology 2003 - “...level of expression of the lac operon (b0344 to b0342) (but see below). In addition, it resulted in elevated levels of expression of the nagBACD (b0678 to...”
- “...11, 2017 by University of California, Berkeley b0344 b0343 b0342 GROWTH DEFECTS OF E. COLI MG1655 VOL. 185, 2003 5619 TABLE 4. Activity of -amylase in MG1655...”
- DNA microarray analyses of the long-term adaptive response of Escherichia coli to acetate and propionate
Polen, Applied and environmental microbiology 2003 - “...1.84* 1.63* 2.10* 2.14* 2.07* 0.78 0.94 0.87 b0342 b0343 b0344 lacA lacY lacZ 1 1 1 Thiogalactoside acetyltransferase Galactoside permease (M protein)...”
- Genome-wide expression profiling in Escherichia coli K-12
Richmond, Nucleic acids research 1999 - “...by IPTG Bnumbera Nameb Radioactivec Microarrayd Gene producte b0342 lacA 79 43 Thiogalactoside acetyltransferase b0344 lacZ 62 49 -D-galactosidase b0343 lacY 55...”
BHE19_RS15305 acetyltransferase from Flavobacterium tructae
37% identity, 47% coverage
LOC107804363 serine acetyltransferase 2-like from Nicotiana tabacum
31% identity, 35% coverage
- Alternative Oxidase Inhibition Impairs Tobacco Root Development and Root Hair Formation
Liu, Frontiers in plant science 2021 - “...several DEGs (|log 2 FC 1|) were commonly enriched in these pathways, i.e., LOC107808059 and LOC107804363, which encode serine acetyltransferase, were enriched in the KEGG pathways of Carbon metabolism, Biosynthesis of amino acids, and Cysteine and methionine metabolism, and showed upregulation on SHAM treatment ( Figures...”
CCNA_01063 putative UDP-perosamine 4-acetyl transferase from Caulobacter crescentus NA1000
35% identity, 49% coverage
- Exopolysaccharide production in Caulobacter crescentus: A resource allocation trade-off between protection and proliferation
Herr, PloS one 2018 - “...(CCNA_01062) encoded on the chromosome is expressed in an operon with perA (CCNA_01064) and perB (CCNA_01063), as well as two predicted glycosyltransferases (CCNA_01065 and CCNA_1066) and the outer membrane transport protein rsaFa [ 29 ], consistent with its role in synthesizing GDP-N-acetylperosamine. The fucose monomer (GDP-fucose)...”
- “...C . crescentus lipopolysaccharide O-antigen [ 30 ], through the activity of two adjacent genes (CCNA_01063, perB and CCNA_01064, perA ). The gmd1 operon structure in which gmd1 , perA , and perB , are co-expressed in an operon with two predicted glycosyltransferases involved in lipopolysaccharide...”
SPD_0949 bacterial transferase hexapeptide (three repeats), putative from Streptococcus pneumoniae D39
31% identity, 56% coverage
- The five homologous CiaR-controlled Ccn sRNAs of Streptococcus pneumoniae modulate Zn-resistance
De, PLoS pathogens 2024 - “...protein 2.16 3.27 SPD_0947 hypothetical protein 2.69 3.97 SPD_0948 nikS nikkomycin biosynthesis protein 3.73 4.29 SPD_0949 N-acetylneuraminate synthase 2.38 4.85 SPD_0950 mefE macrolide ABCE transporter subunit 2.44 3.99 SPD_1045 degenerate DUF3884 domain protein 4.73 6.81 SPD_1046 lacG-2 6-phospho-b-galactosidase 3.56 7.28 SPD_1047 lacE-2 lactose PTS transporter subunit...”
- A Quorum-Sensing System That Regulates Streptococcus pneumoniae Biofilm Formation and Surface Polysaccharide Production
Junges, mSphere 2017 - “...4.87E-03 Membrane protein, putative SPD_0950 ABJ53827.1 17.18 188.70 10.98 5.05E-13 Transporter major facilitator family protein SPD_0949 ABJ54337.1 12.78 100.06 7.83 7.31E-07 Bacterial transferase hexapeptide (three repeats), putative a NCBI protein coding gene. b GenBank. c mRNA log 2 reads. The third and fourth columns show the...”
- “...operon, with no candidate terminators, and the MicrobesOnline database predicts an operon from SPD_0940 to SPD_0949 ( 26 ). While our data cannot exclude the possibility that they actually form a separate operon, it was clear that upon sSHP stimulation, the transcript extended all the way...”
4eaaA / O85353 X-ray crystal structure of the h141n mutant of perosamine n- acetyltransferase from caulobacter crescentus in complex with coa and gdp-perosamine (see paper)
35% identity, 49% coverage
- Ligands: gdp-perosamine; coenzyme a (4eaaA)
EF_RS05155 sugar O-acetyltransferase from Enterococcus faecalis V583
37% identity, 40% coverage
- Mitoxantrone targets both host and bacteria to overcome vancomycin resistance in Enterococcus faecalis
da, Science advances 2023 - “...OG1RF+VRE dead/deah 1.208 E. faecalis OG1RF + VRE MTX R dead/deah 4.832 E. faecalis OG1RF+VRE EF_RS05155 0.604 E. faecalis OG1RF + VRE MTX R EF_RS05155 0.604 E. faecalis OG1RF+VRE EF_RS07835 0.604 E. faecalis OG1RF + VRE MTX R EF_RS07835 0.604 E. faecalis OG1RF+VRE EF_RS09020 0.604 E....”
- “...S6) were designed to incorporate the restriction sites Xho I and Bam HI. The genes EF_RS05155, EF_RS07835, and EF_RS09020 from both VRE and VRE MTX R strains were also cloned using In-Fusion cloning (TaKaRa Bio) with plasmid 1 and primers 5 to 14 (tables S5 and...”
SAT_STABO / G0YF19 Sophorolipid acetyltransferase; Carboxyhydrate transacetylase; EC 2.3.1.- from Starmerella bombicola (Yeast) (Candida bombicola) (see 4 papers)
42% identity, 29% coverage
- function: Catalyzes the optional acetylation of acidic sophorolipids (SLs) at the 6' and/or 6'' carbon atom of the sophorose head group to produce acetylated acidic SLs in sophorolipid biosynthesis (PubMed:21702032, PubMed:23516968, PubMed:26298016). Has no activity toward lactonic sophorolipids, confirmimg that acetylation must precede lactonization (PubMed:26298016).
disruption phenotype: Produces purely unacetylated sophorolipids. Yields mainly lactonic SLs, in addition to minor amounts of acidic SLs.
AL538_RS01055 sugar O-acetyltransferase from Vibrio harveyi
38% identity, 33% coverage
SAT2_ARATH / Q8S895 Serine acetyltransferase 2; AtSAT-2; AtSERAT3;1; EC 2.3.1.30 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
NP_565421 Trimeric LpxA-like enzymes superfamily protein from Arabidopsis thaliana
AT2G17640 ATSERAT3;1; acetyltransferase/ serine O-acetyltransferase from Arabidopsis thaliana
33% identity, 38% coverage
- catalytic activity: L-serine + acetyl-CoA = O-acetyl-L-serine + CoA (RHEA:24560)
subunit: Homomultimer. - Comparative genomics and reverse genetics analysis reveal indispensable functions of the serine acetyltransferase gene family in Arabidopsis.
Watanabe, The Plant cell 2008 - GeneRIF: SERAT3;1 may play a major role during seed development.
- In silico assessment of gene function involved in cysteine biosynthesis in Arabidopsis: expression analysis of multiple isoforms of serine acetyltransferase.
Noji, Amino acids 2006 (PubMed)- GeneRIF: From the results of sensitivity to feedback regulation, subcellular localization and expression of mRNA analyses, each serine acetyltransferase (SATase) isoform seems to have its specific role for cysteine biosynthesis.
- Characterization and expression analysis of a serine acetyltransferase gene family involved in a key step of the sulfur assimilation pathway in Arabidopsis.
Kawashima, Plant physiology 2005 - GeneRIF: Serat3;1 and Serat3;2, were characterized with respect to their enzymatic properties, feedback inhibition by L-Cys, and subcellular localization. [Serat3;1]
- Photorespiration: regulation and new insights on the potential role of persulfidation
Aroca, Journal of experimental botany 2023 - “..., N (11) AT3G59760 Q43725 OASC Cysteine synthase mitochondrial P (3,4) , S (5,7) AT2G17640 Q8S895 SAT2 Serine acetyltransferase 2 P (3) AT3G13110 Q39218 SAT3 Serine acetyltransferase 3, mitochondrial P (3) , S (5,7) AT5G56760 Q42538 SAT5 Serine acetyltransferase 5 P (3) AT5G04590 Q9LZ66 SIR Assimilatory...”
- New insights into the regulation of plant metabolism by O-acetylserine: sulfate and beyond
Apodiakou, Journal of experimental botany 2023 - “...and SERAT2;2 (AT3G13110), which are localized in plastids and mitochondria, respectively, and SERAT1;1 (AT5G56760), SERAT3;1 (AT2G17640), and SERAT3;2 (AT4G35640), which are localized and expressed in the cytosol ( Watanabe et al. , 2008 ; Krueger et al. , 2009 ). When plants experience reduced sulfate levels,...”
- “...Table 1 ). Of the five SERAT genes, SERAT1;1 (At5g56760), SERAT2;1 (At1g55920), SERAT2;2 (At3g13110), SERAT3;1 (At2g17640), and SERAT3;2 (At4g35640), each has a different transcriptional response to certain conditions ( Watanabe and Hoefgen, 2017 ). It was shown that SERAT group III genes are highly induced under...”
- Photorespiration: regulation and new insights on the potential role of persulfidation
Aroca, Journal of experimental botany 2023 - “...(5,6,7) , N (11) AT3G59760 Q43725 OASC Cysteine synthase mitochondrial P (3,4) , S (5,7) AT2G17640 Q8S895 SAT2 Serine acetyltransferase 2 P (3) AT3G13110 Q39218 SAT3 Serine acetyltransferase 3, mitochondrial P (3) , S (5,7) AT5G56760 Q42538 SAT5 Serine acetyltransferase 5 P (3) AT5G04590 Q9LZ66 SIR...”
- Analysis of Alternative Splicing During the Combinatorial Response to Simultaneous Copper and Iron Deficiency in Arabidopsis Reveals Differential Events in Genes Involved in Amino Acid Metabolism
Mancini, Frontiers in plant science 2022 - “...AT2G13360 ALANINE:GLYOXYLATE AMINOTRANSFERASE (AGT) Serine-glycine-cysteine group.cysteine.OASTL AT3G22460 O-ACETYLSERINE (THIOL) LYASE ISOFORM A2 (OASA2) Serine-glycine-cysteine group.cysteine.SAT AT2G17640 SERINE O-ACETYLTRANSFERASE (ATSERAT3;1) Aromatic aa.tryptophan.phosphoribosyanthranilate isom AT5G05590 PHOSPHORIBOSYLANTHRANILATE ISOMERASE 2 (PAI2) Aromatic aa.tryptophan.phosphoribosyanthranilate isom AT1G07780 PHOSPHORIBOSYLANTHRANILATE ISOMERASE 1 (PAI1) Aromatic aa.tryptophan.indole-3-glycerol phosphate synt AT5G48220 Indole-3-glycerol phosphate synthase, putative (InGPS) Aromatic...”
- Chemical Priming by Isothiocyanates Protects Against Intoxication by Products of the Mustard Oil Bomb
Ferber, Frontiers in plant science 2020 - “...serine acetyltransferase (SAT) gene family: SERAT1;1 (At5g56760, SAT-c), SERAT2;1 (At1g55920, SAT-p), SERAT2;2 (At3g13110, SAT-m), SERAT3;1 (At2g17640, SAT-106) and SERAT3;2 (At4g35640). Except for SERAT2;1 which was found to be induced by 1.6-fold by SF 4 h after treatment, none of these genes appeared to be regulated by...”
- The Effect of Single and Multiple SERAT Mutants on Serine and Sulfur Metabolism
Watanabe, Frontiers in plant science 2018 - “...Gene name AGI code Localization SERAT1;1 At5g56760 Cytosol SERAT2;1 At1g55920 Plastids SERAT2;2 At3g13110 Mitochondria SERAT3;1 At2g17640 Cytosol SERAT3;2 At4g45640 Cytosol Despite of the fact that OAS and cysteine are synthesized in multiple subcellular compartments, Arabidopsis knockout mutants lacking one or retaining only one compartment specific SERAT...”
- Agronomic and Seed Quality Traits Dissected by Genome-Wide Association Mapping in Brassica napus
Körber, Frontiers in plant science 2016 - “...17808711 FAR7 832303 AT5G22420 78 16964614 16964759 16964687 844025 SUL SUL.A6.s.1 A06 18128799 ATSERAT3;1 816271 AT2G17640 76 17771333 17772947 17772140 356659 APK3 821077 AT3G03900 76 17301192 17301351 17301272 827528 APK4 836888 AT5G67520 76 17300756 17301552 17301154 827645 SUL.A9.s.1 A09 3084578 APK4 836888 AT5G67520 80 3615223 3615740...”
- “...80 3615223 3615740 3615482 1084222 APK3 821077 AT3G03900 78 3615562 3615705 3615634 1084374 ATSERAT3;1 816271 AT2G17640 75 4588363 4588772 4588568 2057308 For abbreviations of the traits see Table 1 and for the full list of candidate genes see Table S2 . a Chr. is the chromosome...”
- Identification of miRNAs associated with dark-induced senescence in Arabidopsis
Huo, BMC plant biology 2015 - “...all 44 miRNAs were predicted, and some of them, such as NAC1 , At3g28690 , At2g17640 and At2g45160 , were found in the Leaf Senescence Database (LSD). GO and KEGG analysis of 137 miRNAs showed that the predicted target genes were significantly enriched in transcription regulation,...”
- “...(Fig. 6 ). Bioinformatics predictive analysis identified NAC1 , At1g73440 (calmodulin-related protein), At2g03220 (galactoside 2--L-fucosyltransferase), At2g17640 (serine acetyltransferase), At2g26950 (MYB domain protein), At2g45160 (protein lost meristems 1), At28690 (putative protein kinase), At5g54810 (tryptophan synthase beta chain) as target genes of miR164a, miR5020c, miR158b, miR156j, miR159a, miR171a,...”
- Characterization of the serine acetyltransferase gene family of Vitis vinifera uncovers differences in regulation of OAS synthesis in woody plants
Tavares, Frontiers in plant science 2015 - “...minor SERAT isoforms in Arabidopsis, which is in full agreement with low transcription of AtSERAT3;1 (At2g17640) and AtSERAT3;2 (At4g35640) and poor enzymatic activities of recombinant AtSERAT3;1 and AtSERAT3;2 proteins, when compared to the major SERAT belonging to group 1 and 2 (Kawashima et al., 2005 )....”
- More
SRU_0606 pilin glycosylation protein PglB from Salinibacter ruber DSM 13855
36% identity, 47% coverage
- Metagenomic islands of hyperhalophiles: the case of Salinibacter ruber
Pasić, BMC genomics 2009 - “...translocation through the outer membrane in other Gram negatives [ 27 ], while SRU_0598 and SRU_0606 are ABC transporters. Furthermore, SRU_0594 shows features typical to that of a chain length determinant protein Wzz. It contains two transmembrane segments, located in the amino and carboxyl ends and...”
EC042_RS02000 galactoside O-acetyltransferase from Escherichia coli 042
27% identity, 64% coverage
DDB_G0291538 hypothetical protein from Dictyostelium discoideum AX4
Q54ED9 Acetyltransferase from Dictyostelium discoideum
35% identity, 47% coverage
SPy1065 putative acetyltransferase from Streptococcus pyogenes M1 GAS
31% identity, 44% coverage
BL105A_0413 DapH/DapD/GlmU-related protein from Bifidobacterium longum
32% identity, 51% coverage
- Capsular polysaccharide inhibits adhesion of Bifidobacterium longum 105-A to enterocyte-like Caco-2 cells and phagocytosis by macrophages
Tahoun, Gut pathogens 2017 - “...is designated here as the eps1 operon. The 2nd and largest set is BL105A_0408 to BL105A_0413, as the eps2 operon. The 3rd operon is BL105A_0414 to BL105A_0417 , as the eps3 operon. The 4th set, BL105A_0424 to BL105A_0427, is designated as the eps4 operon. The EPS...”
- “...Possible GTF WP_009854068.1 Streptococcus gallolyticus 41 BL105A_0412 cpsF 890 GTF WP_015131440.1 Calothrix sp.PCC 7507 29 BL105A_0413 cpsG 533 Possible GTF WP_009854068.1 Streptococcus gallolyticus 42 BL105A_0414 wzy 797 Oligosaccharide repeat unit polymerase WP_009854069 Streptococcus gallolyticus 34 BL105A_0415 cpsP 1100 Polysaccharide pyruvyl transferase WP_004405434 Vibrio nigripulchritudo 26 BL105A_0416...”
YJL218W Putative protein of unknown function, similar to bacterial galactoside O-acetyltransferases; induced by oleate in an OAF1/PIP2-dependent manner; promoter contains an oleate response element consensus sequence; non-essential gene from Saccharomyces cerevisiae
P40892 Putative acetyltransferase YJL218W from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
49% identity, 25% coverage
- Exploring Saccharomycotina Yeast Ecology Through an Ecological Ontology Framework
Harrison, Yeast (Chichester, England) 2024 - “...is annotated in the S. cerevisiae genome as an uncharacterized ORF with the systematic name YJL218W. In yeasts isolated from animals, 87% (295/339) have a copy of this gene compared to only 66% (495/747) of nonanimal yeasts. Previous work has shown that Oaf1p/Pip2p induces this gene...”
- “...of oleate as a singular carBon source ( Rottensteiner et al. 2003 ). Moreover, the YJL218W deletion strain of S. cerevisiae had decreased cell membrane integrity and reduced capacity to grow in high salt concentrations ( Li et al. 2022 ). In a general framework, the...”
- Systematic profiling of ale yeast protein dynamics across fermentation and repitching
Garge, G3 (Bethesda, Md.) 2024 - “...and YKL091C , YLR177W , YDR391C , YER034W , YKL063C , YER152C , YML020W , YJL218W , YNL011C , YGR266W , YBR137W , YBL055C in cluster 7c from Fig. 2 , see Supplementary Table 7 ). Further studies characterizing these sets of proteins will shed light...”
- Deletion of YJL218W reduces salt tolerance of Saccharomyces cerevisiae
Li, Journal of basic microbiology 2022 (PubMed)- “...The YJL218W open reading frame may be involved in peroxisomal biogenesis. However, whether it mediates salt tolerance is unclear. We found that after knockdown of YJL218W in Saccharomyces cerevisiae (S. cerevisiae), its...”
- “...tolerance was reduced and cell death was increased. Transcriptome sequencing and analysis further revealed that YJL218W knockdown mediated significant changes in the expression of 1432 messenger RNA (mRNAs), of which 603 were upregulated. KEGG enrichment analysis and polymerase chain reaction (PCR) assay indicated that YJL218W mediated...”
- Complete genome sequence and analysis of a Saccharomyces cerevisiae strain used for sugarcane spirit production
Costa, Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] 2021 - “...(MST28) YAR027W (UIP3) YAR031W (PRM9) YGL053W (PRM8) YJL218W YJL217W (REE1) YLR155C (ASP3-1) YLR157C (ASP3-2) YLR157C (ASP3-3) YLR160C (ASP3-4) YGR288W (MAL13)...”
- Identification of the Genetic Requirements for Zinc Tolerance and Toxicity in Saccharomyces cerevisiae
Zhao, G3 (Bethesda, Md.) 2020 - “...YHR112C YKL044W MMO1 YNL204C SPS18 YDL041W YHR151C MTC6 YLR149C YPL261C YDR203W YJL211C YLR232W YPR123C YDR417C YJL218W YMR265C a Gene names were listed alphabetically according to their systemic names. b The mutations for 48 genes that were reported sensitive to zinc previously were underlined. Gene Ontology (GO)...”
- Transcriptome Profile of Yeast Strain Used for Biological Wine Aging Revealed Dynamic Changes of Gene Expression in Course of Flor Development
Mardanov, Frontiers in microbiology 2020 - “...(Dn4) at the mature biofilm stage as compared to the early stage. Five genes, namely YJL218W (acetyltransferase), AIF1 (apoptosis-inducing factor 1), ENB1 (siderophore iron transporter), REE1 (regulator of enolase expression), CSS3 (hypothetical protein) were found to be expressed only at the mature biofilm stage. FIGURE 1...”
- The Swr1 chromatin-remodeling complex prevents genome instability induced by replication fork progression defects
Srivatsan, Nature communications 2018 - “...htz1 mutant, none of these genes showed increased expression, and two GCR-suppressing genes, PHR1 and YJL218W , showed a minor ~40% reduction in expression. Defects in PHR1 and YJL218W result in a minor increase in GCR patch score in the sGCR assay, which is of borderline...”
- Pathways and Mechanisms that Prevent Genome Instability in Saccharomyces cerevisiae
Putnam, Genetics 2017 - “...KCH1 YJL173C RFA3 YDL162C YDL162C YDR499W LCD1 YJR068W RFC2 YHL026C YHL026C YDR439W LRS4 YOL094C RFC4 YJL218W YJL218W YBL023C MCM2 YBR087W RFC5 YKR023W YKR023W YLR274W MCM5 YLR453C RIF2 YMR284W YKU70 YBR136W MEC1 YPR018W RLF2 YMR106C YKU80 YLR288C MEC3 YDR255C RMD5 YML002W YML002W YIL128W MET18 YPL024W RMI1 YML020W...”
- More
- Regulation and adaptive evolution of lactose operon expression in Lactobacillus delbrueckii.
Lapierre, Journal of bacteriology 2002
SSUR61_2113 DapH/DapD/GlmU-related protein from Streptococcus suis R61
38% identity, 40% coverage
Ava_1668 Serine O-acetyltransferase from Anabaena variabilis ATCC 29413
38% identity, 44% coverage
alr1404 serine acetyltransferase from Nostoc sp. PCC 7120
36% identity, 44% coverage
CD1595 serine acetyltransferase from Clostridium difficile 630
36% identity, 49% coverage
- c-di-AMP signaling is required for bile salt resistance, osmotolerance, and long-term host colonization by Clostridioides difficile
Oberkampf, Science signaling 2022 - “...(FAD)dependent oxidoreductase 4 4.73 10 09 CD1796 4Fe-4S binding domain protein 3.57 9.49 10 07 CD1595 ( cysE ) Serine O -acetyltransferase 2.22 4.41 10 04 CD2004 ( effR ) MarR family transcriptional regulator 2.13 2.92 10 03 CD29972999 ABC-type transport system, iron family 2.04 to...”
- Control of Clostridium difficile Physiopathology in Response to Cysteine Availability
Dubois, Infection and immunity 2016 - “...al. are as follows: cysE, serine O-acetyltransferase (CD1595); cysK, OAS-thiol-lyase (CD1594); asrABC, anaerobic sulfite reductase (CD2231 to -2233); ssuCBA1,...”
- “...CD3274 (feoB3) CD2878 (fhuD) CD2875 (fhuC) CD1594 (cysK) CD1595 (cysE) CD1999 (fldX) CD1777 CD1485 CD2499 CD2881 CD2992 CD2991 CD2989 Ferric uptake regulation...”
- Global transcriptional control by glucose and carbon regulator CcpA in Clostridium difficile
Antunes, Nucleic acids research 2012 - “...tdcB (CD2514), threonine dehydratase II; serA (CD0995), putative D-3-phosphoglycerate dehydrogenase; sdaB (CD3222), L-serine dehydratase; cysE (CD1595), serine acetyltransferase; cysK (CD1594), O -acetylserine sulphydrylase; iscS2 (CD1279), cysteine desulphurase; oppBCADF (CD0853CD0857), oligopeptide ABC transporter; CD2177CD2174, cystine ABC transporter; prdF (CD3237), proline racemase; prdE (CD3239), proline reductase; prdA (CD3244),...”
CD630_15950, CDIF630erm_01768 serine O-acetyltransferase EpsC from Clostridioides difficile 630
36% identity, 49% coverage
- Human-Gut Phages Harbor Sporulation Genes
Schwartz, mBio 2023 - “...regulator, sporulation initiation inhibitor, chromosome partitioning protein K00390 BSU_10930 yitB NR Phosphoadenosine phosphosulfate reductase K00640 CD630_15950 cysE NR Serine acetyltransferase (SAT) K00820 CD630_1200 glmS NR Glucosamine-fructose-6-phosphate aminotransferase (isomerizing) K00974 BSU_22450 cca NR CCA-adding enzyme K01142 BSU_40880 exoA NR Exodeoxyribonuclease, repair of oxidative DNA damage in spores...”
- Thiol Metabolism and Volatile Metabolome of Clostridioides difficile
Biwer, Frontiers in microbiology 2022 - “...Bogicevic et al., 2016 ). This step may be realized by secondary activity of CysE (CDIF630erm_01768) or another putative acetyltransferase present in C. difficile 630 erm (e.g., CDIF630erm_00789). With a proper leaving group in place, sulfur introduction might follow directly by reaction with cysteine. The cystationine...”
LBDG_53060 serine O-acetyltransferase from Leptolyngbya boryana dg5
37% identity, 43% coverage
TM0666 serine acetyltransferase from Thermotoga maritima MSB8
36% identity, 46% coverage
A0A0C5DES6 serine O-acetyltransferase (EC 2.3.1.30) from Vitis vinifera (see paper)
33% identity, 37% coverage
3igjC / A0A6L7H2S4 Crystal structure of maltose o-acetyltransferase complexed with acetyl coenzyme a from bacillus anthracis
53% identity, 23% coverage
- Ligand: acetyl coenzyme *a (3igjC)
EPSM_BACSU / P71063 UDP-N-acetylbacillosamine N-acetyltransferase; EC 2.3.1.203 from Bacillus subtilis (strain 168) (see 3 papers)
37% identity, 49% coverage
- function: Catalyzes the conversion of UDP-2,4,6-trideoxy-2-acetamido-4- amino glucose to UDP-2,4,6-trideoxy-2,4-diacetamido glucose, commonly known as UDP-N,N'-diacetylbacillosamine (UDP-diNAcBac).
catalytic activity: UDP-N-acetylbacillosamine + acetyl-CoA = UDP-N,N'- diacetylbacillosamine + CoA + H(+) (RHEA:34159)
subunit: Forms oligomers.
disruption phenotype: Insertion mutant shows decreased efficiency of biofilm formation. Disruption affects swarming motility. - EpsM from Bacillus subtilis 168 has UDP-2,4,6-trideoxy-2-acetamido-4-amino glucose acetyltransferase activity in vitro
Kaundinya, Biochemical and biophysical research communications 2018 (PubMed)- “...V. Abstract Bacillus subtilis 168 EpsM (UniProt id P71063) has been electronically annotated as putative acetyltransferase in the UniProt database. The gene...”
- “...Abstract Bacillus subtilis 168 EpsM (UniProt id P71063) has been electronically annotated as putative acetyltransferase in the UniProt database. The gene...”
SCO7519 sugar acetyltransferase from Streptomyces coelicolor A3(2)
37% identity, 36% coverage
M634_19235 sugar O-acetyltransferase from Vibrio parahaemolyticus O1:Kuk str. FDA_R31
32% identity, 39% coverage
- Comparative Proteomics and Secretomics Revealed Virulence and Antibiotic Resistance-Associated Factors in Vibrio parahaemolyticus Recovered From Commonly Consumed Aquatic Products
Zhu, Frontiers in microbiology 2020 - “...Inorganic diphosphatase A79_0160 33,028.53 4.59 13.95 Metal ion binding, pyrophosphatase activity, cytoplasm P91 S5IS60 Acetyltransferase M634_19235 20,444.06 5.27 28.26 Acetyltransferase activity P92 Z2EFM2 Single-stranded DNA-binding protein ssb 19,563.39 5.18 31.25 Single-stranded DNA binding, DNA recombination, DNA repair, DNA replication P93 A0A2S1MAR5 tRNA-specific 2-thiouridylase MnmA mnmA 42,212.27...”
Cthe_2642 transferase hexapeptide repeat from Clostridium thermocellum ATCC 27405
29% identity, 53% coverage
- Global transcriptome analysis of Clostridium thermocellum ATCC 27405 during growth on dilute acid pretreated Populus and switchgrass
Wilson, Biotechnology for biofuels 2013 - “...1.05 0.26 1.34 Cthe_2640 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolyzing -1.87 -0.44 0.07 0.00 -1.69 -0.94 -3.63 -1.38 Cthe_2642 Sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family -2.57 -1.75 -0.35 0.36 -1.73 -0.13 -3.95 -2.24 Cthe_2643 Nucleotidyltransferase -2.48 -0.73 -0.89 0.10 -1.97 -0.30 -3.55 -1.13 Cthe_2644 DegT/DnrJ/EryC1/StrS aminotransferase -2.38 -1.27...”
- “...Cthe_1084, and Cthe_1759), a glycosyltransferase (Cthe_1085), and genes involved in nucleotide and amino sugar metabolism (Cthe_2642 and Cthe_2644) (Table 4 ). Other genes affected in the growth stage comparison include an anti-sigma factor (Cthe_1437) and a putative ABC transporter subunit (Cthe_2573). These genes are potentially contributing...”
4n27A / Q2YQG1 X-ray structure of brucella abortus rica (see paper)
Q2YQG1 Bacterial transferase hexapeptide repeat from Brucella abortus (strain 2308)
BAB1_1279 Bacterial transferase hexapeptide repeat from Brucella melitensis biovar Abortus 2308
BMEI0736 FERRIPYOCHELIN BINDING PROTEIN from Brucella melitensis 16M
BruAb1_1263 ferripyochelin-binding protein, hypothetical from Brucella abortus biovar 1 str. 9-941
30% identity, 58% coverage
- Ligand: zinc ion (4n27A)
- Lysine Acylation Modification Landscape of Brucella abortus Proteome and its Virulent Proteins
Zhang, Frontiers in cell and developmental biology 2022 - “...(2121359 bp) Chromosome II NC_007624 (1156948 bp) LP2o LPSc LPAc LPCr LPMa Effectors RicA BAB1_1279 Q2YQG1 4 5 3 5 1 VceA BAB1_1652 Q2YRI6 5 1 0 3 0 VceC BAB1_1058 Q2YQ34 2 2 1 2 2 BPE043 BAB1_1043 Q2YQ47 23 19 10 17 4 BtpA...”
- Lysine Acylation Modification Landscape of Brucella abortus Proteome and its Virulent Proteins
Zhang, Frontiers in cell and developmental biology 2022 - “...NC_007618 (2121359 bp) Chromosome II NC_007624 (1156948 bp) LP2o LPSc LPAc LPCr LPMa Effectors RicA BAB1_1279 Q2YQG1 4 5 3 5 1 VceA BAB1_1652 Q2YRI6 5 1 0 3 0 VceC BAB1_1058 Q2YQ34 2 2 1 2 2 BPE043 BAB1_1043 Q2YQ47 23 19 10 17 4...”
- Uncovering the Hidden Credentials of Brucella Virulence
Roop, Microbiology and molecular biology reviews : MMBR 2021 (secret) - Epistatic Interplay between Type IV Secretion Effectors Engages the Small GTPase Rab2 in the Brucella Intracellular Cycle
Smith, mBio 2020 - “...deletion of ricA , 1,000-bp regions of the Brucella genome upstream and downstream of ricA (BAB1_1279) were amplified using primers pairs WSU0345/WSU0346 and WSU0347/WSU0348, respectively. The two resulting fragments were joined by overlap-extension PCR and inserted into pJC80 ( 20 ) using XbaI and SacI restriction...”
- The Intracellular Life Cycle of <i>Brucella</i> spp
Celli, Microbiology spectrum 2019 - “...Author Manuscript Host target Function RicA VceA BAB1_1279 Rab2 modulates rBCV biogenesis (28) BAB1_1652 unknown unknown (27) VceC BAB1_1058 Grp78/BiP UPR...”
- Type IV secretion system of Brucella spp. and its effectors
Ke, Frontiers in cellular and infection microbiology 2015 - “...ORF in B. abortus Amino acids Conserved domains Targets within hosts Functions Methods References RicA BAB1_1279 175 Carbonic anhydrase Rab2 Regulating vesicle trafficking TEM1 de Barsy et al., 2011 ; Nkengfac et al., 2012 ; Herrou and Crosson, 2013 VceA BAB1_1652 105 Non Unknown Unknown CyaA,...”
- Ontology-based representation and analysis of host-Brucella interactions
Lin, Journal of biomedical semantics 2015 - “...the Brucella T4SS virulence mechanism (Fig. 4 ). Brucella RicA, encoded by a Brucella gene BMEI0736, binds to human small GTPase protein Rab2 [ 43 ]. RicA is translocated from B. abortus to infected macrophages. However, this phenomenon does not occur when a Brucella virB mutant...”
- Molecular structure of the Brucella abortus metalloprotein RicA, a Rab2-binding virulence effector
Herrou, Biochemistry 2013 - “...expression plasmids The sequence encoding residues M1 to A175 of Brucella abortus RicA (gene number BruAb1_1263 ) was amplified by PCR from B. abortus genomic DNA. Primers used for amplification were RicA-UP, ATAT CATATG CCGATCTATGCATATAACGG ( Nde I) and RicA-LO, ATAT AAGCTT TCAGGCAGGCTCCATGCCG ( Hind III),...”
WANG_1291 DapH/DapD/GlmU-related protein from Lactobacillus kefiranofaciens subsp. kefiranofaciens
54% identity, 22% coverage
6wyeA / Q5F6X0 Crystal structure of neisseria gonorrhoeae serine acetyltransferase (cyse) (see paper)
35% identity, 40% coverage
- Ligand: (2s)-2-hydroxybutanedioic acid (6wyeA)
NGFG_01496, NGFG_RS07905 serine O-acetyltransferase from Neisseria gonorrhoeae MS11
Q5F6X0 Serine acetyltransferase from Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090)
35% identity, 38% coverage
- Serine acetyltransferase from Neisseria gonorrhoeae; structural and biochemical basis of inhibition
Oldham, The Biochemical journal 2022 - “...for expression in Escherichia coli The SAT gene (annotated cysE ) NGFG_RS07905 (old locus tag NGFG_01496) from N. gonorrhoeae MS11 was codon optimized for E. coli and ordered from Geneart (Thermo Fisher). The synthetic NGFG_RS07905 construct was cloned into expression vector pET28b between Ndel and Xhol...”
- “...novel drug target for treating extensively antimicrobial resistant gonorrhoea. Associated content UniProt Accession ID for NGFG_01496 (NgSAT): Q5F6X0 (Q5F6X0_NEIG1) Acknowledgment We thank Professor Vic Arcus and Dr. Claire Mulholland for help and advice regarding solving the structure of NgSAT. This research made use of the SAXS...”
- “...methods Cloning of NgSAT for expression in Escherichia coli The SAT gene (annotated cysE ) NGFG_RS07905 (old locus tag NGFG_01496) from N. gonorrhoeae MS11 was codon optimized for E. coli and ordered from Geneart (Thermo Fisher). The synthetic NGFG_RS07905 construct was cloned into expression vector pET28b...”
- “...Results and discussion Purification and stoichiometry of NgSAT The N. gonorrhoeae serine acetyltransferase (SAT) gene NGFG_RS07905 was cloned into pET28b for expression with an N-terminal His-tag. This was done to avoid adding residues onto the C-terminus of the protein which is proposed to interact with OASS/CysK...”
- Serine acetyltransferase from Neisseria gonorrhoeae; structural and biochemical basis of inhibition
Oldham, The Biochemical journal 2022 - “...target for treating extensively antimicrobial resistant gonorrhoea. Associated content UniProt Accession ID for NGFG_01496 (NgSAT): Q5F6X0 (Q5F6X0_NEIG1) Acknowledgment We thank Professor Vic Arcus and Dr. Claire Mulholland for help and advice regarding solving the structure of NgSAT. This research made use of the SAXS and MX2...”
TepiRe1_2341 serine O-acetyltransferase EpsC from Tepidanaerobacter acetatoxydans Re1
36% identity, 41% coverage
PA3816 O-acetylserine synthase from Pseudomonas aeruginosa PAO1
36% identity, 47% coverage
lmo0431 similar to acetyltransferase from Listeria monocytogenes EGD-e
39% identity, 37% coverage
- [Characterization of a naturally atypical Listeria monocytogenes strain lacking inlAB]
Chen, Wei sheng wu xue bao = Acta microbiologica Sinica 2009 (PubMed)- “...and decreased pathogenicity to mice. It lacked the gene locus inlAB and their adjacent genes lmo0431, lmo0432, lmo0436 and lmo0437, but contained an almost whole set of infection-associated genes. S10 fell into the lineage I cluster and form a sister branch with 4b strain. The isolate...”
- Glycerol metabolism and PrfA activity in Listeria monocytogenes
Joseph, Journal of bacteriology 2008 - “...lmo0400 lmo0405 lmo0415 lmo0426a,b lmo0427a,b lmo0428a,b lmo0429a,b lmo0431 inlAb,d inlBb,d lmo0456 lmo0458 lmo0498 lmo0498 lmo0499 YG-B 5416 JOSEPH ET AL. J....”
RSp1012 DapH/DapD/GlmU-related protein from Ralstonia pseudosolanacearum GMI1000
36% identity, 45% coverage
- Quorum Sensing-Dependent Invasion of Ralstonia solanacearum into Fusarium oxysporum Chlamydospores
Tsumori, Microbiology spectrum 2023 - “...in EPS I biosynthesis, i.e., to change the substructure of EPS I ( Fig.6A ). RSp1012, a LpxA-like protein, transfers a 3-hydroxybutanoate to the 2,4-diamino-2,4,6-trideoxygalactose moiety in EPS I ( 48 ). RSp1012 produced the EPS I that differed in appearance from that of the wild-type...”
- “...than OE1-1 on F. oxysporum hyphae, and their thickness became thinner ( Fig.6C , upper). RSp1012 parasitized the fungus at almost the same rate as the wild-type strain ( Fig.6D ). The deletion of the gene RSp1007 encoding the enzyme that transfers the acetate to amino...”
Q5HCZ5 galactoside O-acetyltransferase (EC 2.3.1.18) from Staphylococcus aureus (see paper)
SAOUHSC_02871 hypothetical protein from Staphylococcus aureus subsp. aureus NCTC 8325
SAUSA300_2492 acetyltransferase family protein from Staphylococcus aureus subsp. aureus USA300_FPR3757
SACOL2570 galactoside O-acetyltransferase from Staphylococcus aureus subsp. aureus COL
26% identity, 44% coverage
- Functional Mapping of Phenotypic Plasticity of Staphylococcus aureus Under Vancomycin Pressure
Yang, Frontiers in microbiology 2021 - “...2,072,412 20.49 / / Non-coding region 0 g/mL 2,644,158 26.92 F < - > F SAOUHSC_02871 Hypothetical protein 0 g/mL 2,728,755 18.98 V < - > I SAOUHSC_02967 Arginine/ornithine antiporter 0 g/mL 2,748,895 19.82 T < - > S SAOUHSC_02982 Hypothetical protein 2 g/mL 92,210 17.59...”
- “...SNP at position 1942424 is located in SAOUHSC_02036, which encodes a phage structural protein. The SAOUHSC_02871 gene (containing SNP 2644158) encodes an acetyltransferase. FIGURE 3 Manhattan plots of bivariate functional mapping. Manhattan plot of the significance test based on the associations between phenotypic plasticity of microbial...”
- Inferring multilayer interactome networks shaping phenotypic plasticity and evolution
Yang, Nature communications 2021 - “...Q25261 (at SAOUHSC_00020 ), Q193712 (at SAOUHSC_00176 ), Q92210 (at SAOUHSC_00085 ), and Q2644158 (at SAOUHSC_02871 ), have significant net effects mainly due to favorable accumulated promotion from regulators, although the strength of promotion and number of regulators differ from QTL to QTL (Fig. S 4C...”
- Loratadine inhibits Staphylococcus aureus virulence and biofilm formation
Zheng, iScience 2022 - “...C751T R251H (nonsyn) SA113_GM000812 SAOUHSC_00,694 Q2G0B1; HTH-type transcriptional regulator MgrA G275T R92L (nonsyn) SA113_GM001371 SAOUHSC_02,871 Q5HCZ5; Putative acetyltransferase SACOL2570 G412A G138S (nonsyn) SA113_GM002521 SAOUHSC_01,877 O35008; Uncharacterized protein YtqA T786C I262I (syn) Note: S.aureus was serially subcultured in TSB containing500M loratadine. Mutations in two clones (81-1, 81-6)...”
- Identification of Methicillin-Resistant Staphylococcus aureus (MRSA) Genetic Factors Involved in Human Endothelial Cells Damage, an Important Phenotype Correlated with Persistent Endovascular Infection
Xiao, Antibiotics (Basel, Switzerland) 2022 - “...compound ABC transporter iron compound-binding protein SirA 11.83 7.84 SAUSA300_0899 mecA adaptor protein 11.58 10.37 SAUSA300_2492 hypothetical acetyltransferase family protein 11.55 7.80 SAUSA300_1433 hypothetical putative phage regulatory protein 11.41 8.17 SAUSA300_1244 mscL large conductance mechanosensitive channel protein 11.32 7.21 SAUSA300_0049 hypothetical hypothetical protein 11.30 0.62 SAUSA300_1667...”
- Cigarette Smoke Extract-Exposed Methicillin-Resistant Staphylococcus aureus Regulates Leukocyte Function for Pulmonary Persistence
Kulkarni, American journal of respiratory cell and molecular biology 2016 - “...SAUSA300_0889 SAUSA300_2175 SAUSA300_0076 SAUSA300_2617 SAUSA300_2492 SAUSA300_2638 SAUSA300_0206 SAUSA300_0784 SAUSA300_2326 SAUSA300_0075 SAUSA300_0952...”
- Loratadine inhibits Staphylococcus aureus virulence and biofilm formation
Zheng, iScience 2022 - “...SA113_GM000812 SAOUHSC_00,694 Q2G0B1; HTH-type transcriptional regulator MgrA G275T R92L (nonsyn) SA113_GM001371 SAOUHSC_02,871 Q5HCZ5; Putative acetyltransferase SACOL2570 G412A G138S (nonsyn) SA113_GM002521 SAOUHSC_01,877 O35008; Uncharacterized protein YtqA T786C I262I (syn) Note: S.aureus was serially subcultured in TSB containing500M loratadine. Mutations in two clones (81-1, 81-6) from 81 generations...”
- The emerging roles of GCN5L1 in mitochondrial and vacuolar organelle biology
Wu, Biochimica et biophysica acta. Gene regulatory mechanisms 2021 - “...suggesting that these regions may be involved in substrate binding. A structural analysis of the SACOL2570 acetyltransferase from Staphylococcus aureus determined that the XAT hexapeptide repeat was an integral component of the substrate binding pockets [ 54 ]. In contrast, GCN5L1 has three XAT hexapeptide repeat...”
- “...Zheng H , Chruszcz M , Minor W , Biophysical analysis of the putative acetyltransferase SACOL2570 from methicillin-resistant Staphylococcus aureus , J Struct Funct Genomics , 14 ( 2013 ) 97 108 . 23963951 [55] Kanehisa M , Goto S , Sato Y , Furumichi M...”
- GCN5L1/BLOS1 Links Acetylation, Organelle Remodeling, and Metabolism
Scott, Trends in cell biology 2018 - “...formation of the correct tertiary structure required for this process. A structural analysis of the SACOL2570 acetyltransferase from Staphylococcus aureus determined that the XAT hexapeptide repeat was integral to the folding of the LH domains that form substrate binding pockets, suggesting that XAT hexapeptide repeat may...”
- “...37 19 6689 96 9578552 27 Luo HB 2013 Biophysical analysis of the putative acetyltransferase SACOL2570 from methicillin-resistant Staphylococcus aureus J Struct Funct Genomics 14 3 97 108 23963951 28 Kanehisa M 2012 KEGG for integration and interpretation of large-scale molecular data sets Nucleic Acids Res...”
- Biophysical analysis of the putative acetyltransferase SACOL2570 from methicillin-resistant Staphylococcus aureus
Luo, Journal of structural and functional genomics 2013 - “...functional genomics 1345-711X 1570-0267 23963951 3923901 10.1007/s10969-013-9158-6 NIHMS520349 Article Biophysical analysis of the putative acetyltransferase SACOL2570 from methicillin-resistant Staphylococcus aureus Luo Hai-Bin Department of Molecular Physiology and Biological Physics, University of Virginia, 1340 Jefferson Park Avenue, Charlottesville, VA 22908, USA; School of Pharmaceutical Sciences, Sun Yat-Sen...”
- “...CoA-bound crystal structures of a member of the galactoside acetyltransferase superfamily from methicillin-resistant S. aureus SACOL2570 which was recently shown to be down regulated in S. aureus grown in the presence of fusidic acid, an antibiotic used to treat MRSA infections. SACOL2570 forms a homotrimerin solution,...”
tlr0851 serine acetyltransferase from Thermosynechococcus elongatus BP-1
35% identity, 47% coverage
- Indirect Interspecies Regulation: Transcriptional and Physiological Responses of a Cyanobacterium to Heterotrophic Partnership
Bernstein, mSystems 2017 - “...) and metabolism of the amino acids cysteine and methionine ( cysE and metE ; tlr0851 and tlr1190 ; coaX and panC-cmk ; tll1149 and tll2450 ) were light responsive with I i , but a smaller number of these genes exhibited such changes in expression...”
- “...cysteine synthases ( cysK ; tlr0504 and SY28_RS03805 ) and serine O-acetyltransferases ( cysE ; tlr0851 and SY28_RS05065 ), which cogrouped into clusters D and A, respectively. Oxidative stress responses. The relative abundance of T. elongatus transcripts encoding enzymes involved with ROS detoxification generally increased with...”
SA2342 hypothetical protein from Staphylococcus aureus subsp. aureus N315
26% identity, 44% coverage
mru_2170 acetyltransferase from Methanobrevibacter ruminantium M1
33% identity, 46% coverage
SAT1 / Q42588 serine acetyltransferase (EC 2.3.1.30) from Arabidopsis thaliana (see 4 papers)
SAT1_ARATH / Q42588 Serine acetyltransferase 1, chloroplastic; AtSAT-1; AtSERAT2;1; SAT-p; EC 2.3.1.30 from Arabidopsis thaliana (Mouse-ear cress) (see 9 papers)
Q42588 serine O-acetyltransferase (EC 2.3.1.30) from Arabidopsis thaliana (see 7 papers)
CAA84371.1 serine acetyltransferase from Arabidopsis thaliana (see paper)
NP_175988 serine acetyltransferase 2;1 from Arabidopsis thaliana
AT1G55920 ATSERAT2;1 (SERINE ACETYLTRANSFERASE 2;1); serine O-acetyltransferase from Arabidopsis thaliana
36% identity, 32% coverage
- function: Serine acetyltransferase which catalyzes the formation of O- acetyl-L-serine from acetyl-CoA and L-serine (PubMed:7851429, PubMed:9830017). Also displays O-acetylserine (thio1)-lyase activity in vitro (PubMed:7851429). May be involved in detoxification process by mediating the production of glutathione.
catalytic activity: L-serine + acetyl-CoA = O-acetyl-L-serine + CoA (RHEA:24560)
subunit: Homomultimer (By similarity). Interacts with OASA1 and CYP20- 3. Component of the cysteine synthase complex (CSC) composed of two OAS-TL dimers and one SAT hexamer. - Overexpression of serine acetlytransferase produced large increases in O-acetylserine and free cysteine in developing seeds of a grain legume.
Tabe, Journal of experimental botany 2010 - GeneRIF: Expression in developing lupin embryos of a serine acetyltransferase (SAT) from Arabidopsis thaliana (AtSAT1 or AtSerat 2;1) was associated with increases of up to 5-fold in the concentrations of O-acetylserine and up to 26-fold in free cysteine.
- Analysis of cytosolic and plastidic serine acetyltransferase mutants and subcellular metabolite distributions suggests interplay of the cellular compartments for cysteine biosynthesis in Arabidopsis.
Krueger, Plant, cell & environment 2009 (PubMed)- GeneRIF: Cytosolic SERAT1.1 and plastidic SERAT2.1 do not contribute to cysteine biosynthesis.
- Comparative genomics and reverse genetics analysis reveal indispensable functions of the serine acetyltransferase gene family in Arabidopsis.
Watanabe, The Plant cell 2008 - GeneRIF: Plastidic SERAT2;1 contributes less to OAS formation and subsequent Cys synthesis.
- Thermodynamics of the interaction between O-acetylserine sulfhydrylase and the C-terminus of serine acetyltransferase.
Kumaran, Biochemistry 2007 (PubMed)- GeneRIF: Binding of the C-terminus of serine acetyltransferase by acetylserine sulfhydrylase contributes a large portion of the total binding energy during formation of the plant cysteine synthase complex.
- In silico assessment of gene function involved in cysteine biosynthesis in Arabidopsis: expression analysis of multiple isoforms of serine acetyltransferase.
Noji, Amino acids 2006 (PubMed)- GeneRIF: From the results of sensitivity to feedback regulation, subcellular localization and expression of mRNA analyses, each serine acetyltransferase (SATase) isoform seems to have its specific role for cysteine biosynthesis.
- New insights into the regulation of plant metabolism by O-acetylserine: sulfate and beyond
Apodiakou, Journal of experimental botany 2023 - “...and Nikiforova, 2008 ). In Arabidopsis five genes encoding SERAT proteins can be found: SERAT2;1 (AT1G55920) and SERAT2;2 (AT3G13110), which are localized in plastids and mitochondria, respectively, and SERAT1;1 (AT5G56760), SERAT3;1 (AT2G17640), and SERAT3;2 (AT4G35640), which are localized and expressed in the cytosol ( Watanabe et...”
- “...( Fig. 2 ; Table 1 ). Of the five SERAT genes, SERAT1;1 (At5g56760), SERAT2;1 (At1g55920), SERAT2;2 (At3g13110), SERAT3;1 (At2g17640), and SERAT3;2 (At4g35640), each has a different transcriptional response to certain conditions ( Watanabe and Hoefgen, 2017 ). It was shown that SERAT group III genes...”
- HYPK promotes the activity of the Nα-acetyltransferase A complex to determine proteostasis of nonAc-X2/N-degron-containing proteins
Miklánková, Science advances 2022 - “...lowering its NTA frequency and not by a pleiotropic effect. The non-NatA substrates MPP SAT5 (AT1G55920) and MRE TUBB4 (AT5G44340) ( Fig. 6, A and B ) were stable in hypk mutants, suggesting that the enhanced global protein turnover in hypk was predominantly triggered by destabilization...”
- Cotranslational N-degron masking by acetylation promotes proteome stability in plants
Linster, Nature communications 2022 - “...OAS-TL A interacting protein MPP SAT5 ( S erine- A cetyl- T ransferase 5 , AT1G55920) and MED COI1 ( CO ronatine- I nsensitive protein 1 , AT2G39940) were not destabilized in NatA depleted plants (Fig. 2d , Supplementary Fig. 3d ). Since the steady-state level...”
- The Phytotoxin Myrigalone A Triggers a Phased Detoxification Programme and Inhibits Lepidium sativum Seed Germination via Multiple Mechanisms including Interference with Auxin Homeostasis
Nakabayashi, International journal of molecular sciences 2022 - “...Oxidoreductase 6.4 43.5 UP UP UP - - - UP UP UP UP DN UP AT1G55920 SAT1 4.7 5.6 UP UP - UP - UP UP UP UP UP - UP AT5G39050 PMAT1 2.0 2.6 UP UP UP UP UP UP UP - UP UP -...”
- Identification of Key Metabolic Pathways and Biomarkers Underlying Flowering Time of Guar (Cyamopsis tetragonoloba (L.) Taub.) via Integrated Transcriptome-Metabolome Analysis
Grigoreva, Genes 2021 - “...0.009 nd AT2G30970 (ASP1); AT5G22300 (NIT4) 0.386; 0.533 0.097; 0.006 C00065 (L-Serine) 0.393 0.008 0.001 AT1G55920 (ATSERAT2;1) 1.448 5.492 10 5 genes-12-00952-t005_Table 5 Table 5 Description of differentially expressed guar transcripts involved in the phosphatidylinositol signaling pathway based on homology with Arabidopsis thaliana on KEGG map...”
- Expression of cyanobacterial genes enhanced CO2 assimilation and biomass production in transgenic Arabidopsis thaliana
Abbasi, PeerJ 2021 - “...involved in oxidative photosynthetic pathway, specifically synthesis of glycerate biosynthesis. 1.03 Timm et al., 2011 AT1G55920 Serine acetyltransferase Involved in cysteine biosynthesis in chloroplasts and cytosol. 1.1 Tavares et al., 2015 AT5G50950 Fumarase It is reportedly located in chloroplasts, cytosol and mitochondria. It is involved in...”
- pH-dependent transcriptional profile changes in iron-deficient Arabidopsis roots
Tsai, BMC genomics 2020 - “...ENDOTRANSGLUCOSYLASE/HYDROLASE 17 0.49 2.95 0.17 AT2G32150 Haloacid dehalogenase-like hydrolase (HAD) superfamily protein 0.49 3.13 0.16 AT1G55920 SAT1, SERINE ACETYLTRANSFERASE 1 0.36 2.56 0.14 AT2G39380 EXO70H2, EXOCYST SUBUNIT EXO70 FAMILY PROTEIN H2 0.39 2.78 0.14 AT4G38540 FAD/NAD(P)-binding oxidoreductase family protein 0.40 2.88 0.14 AT3G11340 UGT76B1, UDP-DEPENDENT GLYCOSYLTRANSFERASE...”
- Chemical Priming by Isothiocyanates Protects Against Intoxication by Products of the Mustard Oil Bomb
Ferber, Frontiers in plant science 2020 - “...five cysteine forming enzymes of the serine acetyltransferase (SAT) gene family: SERAT1;1 (At5g56760, SAT-c), SERAT2;1 (At1g55920, SAT-p), SERAT2;2 (At3g13110, SAT-m), SERAT3;1 (At2g17640, SAT-106) and SERAT3;2 (At4g35640). Except for SERAT2;1 which was found to be induced by 1.6-fold by SF 4 h after treatment, none of these...”
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RSP_2481 serine acetyltransferase from Rhodobacter sphaeroides 2.4.1
39% identity, 39% coverage
- Convergence of the transcriptional responses to heat shock and singlet oxygen stresses
Dufour, PLoS genetics 2012 - “...Other RSP_1825 Protein folding and stabilization RSP_1207 Ribosomal proteins: synthesis and modification RSP_0570 Serine family RSP_2481 Fatty acid and cell envelope Biosynthesis RSP_0473 Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides RSP_2569 Other RSP_3601 DNA metabolism DNA replication, recombination, and repair RSP_2388, RSP_2966 Central intermediary metabolism...”
BOV_1224 serine acetyltransferase 4 (atsat-4) (atserat3;2) from Brucella ovis ATCC 25840
40% identity, 37% coverage
C4IRW0 serine O-acetyltransferase (EC 2.3.1.30) from Brucella abortus (see paper)
40% identity, 36% coverage
4hzdA / A0A0F6AR69 Crystal structure of serine acetyltransferase in complex with coenzyme a from brucella abortus strain s19 (see paper)
40% identity, 39% coverage
- Ligands: coenzyme a; magnesium ion (4hzdA)
ECs0512 putative transferase from Escherichia coli O157:H7 str. Sakai
55% identity, 22% coverage
Maa / b0459 maltose O-acetyltransferase (EC 2.3.1.79) from Escherichia coli K-12 substr. MG1655 (see 7 papers)
maa / P77791 maltose O-acetyltransferase (EC 2.3.1.79) from Escherichia coli (strain K12) (see 6 papers)
MAA_ECOLI / P77791 Maltose O-acetyltransferase; MAT; Maltose transacetylase; EC 2.3.1.79 from Escherichia coli (strain K12) (see 2 papers)
maa maltose O-acetyltransferase; EC 2.3.1.79 from Escherichia coli K12 (see 5 papers)
maa / CAA11147.1 Maltose Transacetylase from Escherichia coli (see paper)
NP_414992 maltose O-acetyltransferase from Escherichia coli str. K-12 substr. MG1655
b0459 maltose O-acetyltransferase from Escherichia coli str. K-12 substr. MG1655
ETEC_0511 maltose O-acetyltransferase from Escherichia coli ETEC H10407
55% identity, 22% coverage
- function: Catalyzes the CoA-dependent transfer of an acetyl group to maltose and other sugars (PubMed:1856235). Acetylates glucose exclusively at the C6 position and maltose at the C6 position of the non-reducing end glucosyl moiety. Is able to acetylate maltooligosaccharides (PubMed:12731863).
catalytic activity: D-maltose + acetyl-CoA = 1-O-acetylmaltose + CoA (RHEA:10456)
subunit: Homodimer. - Expression of an engineered granule-bound Escherichia coli maltose acetyltransferase in wild-type and amf potato plants.
Nazarian, Plant biotechnology journal 2007 (PubMed)- GeneRIF: Expressed in potato plants, and involved in starch biosynthesis.
- Protein identification with N and C-terminal sequence tags in proteome projects.
Wilkins, Journal of molecular biology 1998 (PubMed)- GeneRIF: N-terminus verified by Edman degradation on mature peptide
- The Escherichia coli proteome: past, present, and future prospects
Han, Microbiology and molecular biology reviews : MMBR 2006 - “...heat inducible 5.10/57,695.38 --/60,500 Maa P77791 Maltose O-acetyltransferase 6.19/19,964.80 6.04/22,694 MacA P75830 Macrolide-specific efflux protein...”
- Engineering of bacterial methyl ketone synthesis for biofuels
Goh, Applied and environmental microbiology 2012 - “...luteus), E. coli 76 aem.asm.org Gene name Fold change b1396 b0443 b0459 b4040 b3769 b4039 b1400 paaI fadM maa ubiA ilvM ubiC paaY 3.4 2.3 2.1 2.0 2.0 1.9 1.7...”
- Transcriptomic analysis of Escherichia coli O157:H7 and K-12 cultures exposed to inorganic and organic acids in stationary phase reveals acidulant- and strain-specific acid tolerance responses
King, Applied and environmental microbiology 2010 - “...b2530 b0124 b2466 b0449 ECs0512 ECs5566 ECs2316 ECs0252 b0459 b4458 b1610 b0255 ECs2817 b2015 Amino acid transport and metabolism Carbohydrate transport and...”
- The molecular basis for control of ETEC enterotoxin expression in response to environment and host
Haycocks, PLoS pathogens 2015 - “...TCACA ETEC_0443 aroM 492973 ATC GA TTGCGT TCAC G ETEC_0464 tsx 540805 TGTGA TCTTTA TCACA ETEC_0511 maa 574230 GA TGA CGACGA TCACA (ETEC_0538) (ybaT) 683187 A GTGA TCGAGT T A ACA ETEC_0628 cstA 697540 A GTGA TTTGCG TCACA ETEC_0639 rnk 739223 C GT T A CCCTTG...”
DMR38_19595 serine O-acetyltransferase EpsC from Clostridium sp. AWRP
36% identity, 41% coverage
- Metabolic changes of the acetogen Clostridium sp. AWRP through adaptation to acetate challenge
Kwon, Frontiers in microbiology 2022 - “...found to exhibit strong up-regulation of genes involved in serine (DMR38_00400, 00405, and 00415), cysteine (DMR38_19595 and 19600), and methionine biosynthesis (DMR38_03415, 03420, 12485, 03155, 03160, and 09800) as well as the methionine-transporter-encoding gene (DMR38_16080) ( Figure 6B ). The biosynthesis pathways of aromatic amino acids...”
BT_0521 putative acetyl transferase from Bacteroides thetaiotaomicron VPI-5482
32% identity, 40% coverage
- CRISPR-based screening of small RNA modulators of bile susceptibility in <i>Bacteroides thetaiotaomicron</i>
Prezza, Proceedings of the National Academy of Sciences of the United States of America 2024 - “...on minimal free energy calculations upon BatR annealing), we picked four for further validation, namely BT_0521 (partially homologous to the polysaccharide capsule synthesis protein CpsI from Streptococcus iniae ), BT_1177 (encoding an LPS biosynthesis protein), BT_1195 (encoding a peptidoglycan transglycosylase), and BT_3849 (encoding the LPS-assembly protein...”
- “...medium to mid-exponential phase (OD 600 = 2). The ensuing qRT-PCR analysis revealed derepression of BT_0521 (~eightfold) and BT_1177 (~fivefold) in the absence of BatR, while complementation with full-length BatR partially restored BT_0521 but not BT_1177 repression ( Fig. 6 B ). Steady-state mRNA levels of...”
ERH_0421 serine O-acetyltransferase from Erysipelothrix rhusiopathiae str. Fujisawa
41% identity, 39% coverage
- Rational Design of Live-Attenuated Vaccines against Genome-Reduced Pathogens
Nishikawa, Microbiology spectrum 2022 - “...asnA , aspartate-ammonia ligase (ERH_1353); glyA , glycine hydroxymethyltransferase (ERH_1608); cysE , serine O -acetyltransferase (ERH_0421); cysK , cysteine synthase A (ERH_0469); glyA , glycine hydroxymethyltransferase (ERH_1608); proA , glutamate-5-semialdehyde dehydrogenase (ERH_0055); proB , glutamate 5-kinase (ERH_0054); proC , pyrroline-5-carboxylate reductase (ERH_0057); arcA , arginine deiminase...”
- The genome of Erysipelothrix rhusiopathiae, the causative agent of swine erysipelas, reveals new insights into the evolution of firmicutes and the organism's intracellular adaptations
Ogawa, Journal of bacteriology 2011 - “...O-acetyltransferase (cysE) ...................................................................................................ERH_0421 Cysteine synthase A...”
SAR2635 putative acetyltransferase from Staphylococcus aureus subsp. aureus MRSA252
28% identity, 44% coverage
FI9785_RS04565 sugar O-acetyltransferase from Lactobacillus johnsonii FI9785
30% identity, 44% coverage
Cthe_2066 serine O-acetyltransferase from Clostridium thermocellum ATCC 27405
35% identity, 46% coverage
GLRG_01112 acetyltransferase from Colletotrichum graminicola M1.001
33% identity, 51% coverage
NCgl0354 acetyltransferase from Corynebacterium glutamicum ATCC 13032
28% identity, 73% coverage
Mjls_4306 carbonic anhydrases/acetyltransferases isoleucine patch superfamily-like protein from Mycobacterium sp. JLS
36% identity, 51% coverage
SPAC18B11.09c N-acetyltransferase (predicted) from Schizosaccharomyces pombe
34% identity, 32% coverage
- A single m6A modification in U6 snRNA diversifies exon sequence at the 5' splice site
Ishigami, Nature communications 2021 - “...of the Z -score of each intron. The red and blue arrows represent plots of SPAC18B11.09c intron #1 and sec71 intron #1, respectively. The black line represents an equal value of IRS. c Semi-quantitative RT-PCR analyses of two introns with large IRS difference. The upper and...”
- “...equal value of IRS. b Mutation study with a minigene construct encoding intron #1 of SPAC18B11.09c . Splicing efficiency was measured by RT-PCR using minigene-specific primers, followed by non-denaturing PAGE analysis. The IRS was quantified from the signal intensity ratio of the PCR products with and...”
A8JDD3 serine O-acetyltransferase from Chlamydomonas reinhardtii
37% identity, 21% coverage
PA45B_3233 acetyltransferase from Escherichia coli
29% identity, 68% coverage
Dde_0359 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily from Desulfovibrio desulfuricans G20
34% identity, 47% coverage
- System-Wide Adaptations of Desulfovibrio alaskensis G20 to Phosphate-Limited Conditions
Bosak, PloS one 2016 - “...signaling and sensing, CheY-like Dde_2555 hypothetical protein -1.43 -0.95 -0.24 -3.23 -1.92 -0.27 -1.89 unknown Dde_0359 sugar O-acyltransferase, NeuD family -1.54 -1.96 -1.01 -3.58 -2.79 -1.50 -3.07 cell envelope biosynthesis Dde_0014 methionyl-tRNA formyltransferase -2.63 -3.56 -2.85 -4.24 -4.29 -2.14 -3.15 folate metabolism, peptide biosynthesis, amino acid...”
- “...defects included Dde_0362, a sugar transferase, with an expected role in the biosynthesis of lipopolysaccharide, Dde_0359, a sugar O-acyltransferase similar to NeuD, a protein contributing to the capsular synthesis in E . coli [ 80 ] and Dde_2945, a phosphomannomutase/phosphoglucomutase similar to those with roles in...”
An01g14790 uncharacterized protein from Aspergillus niger
29% identity, 51% coverage
- Metabolic peculiarities of Aspergillus niger disclosed by comparative metabolic genomics
Sun, Genome biology 2007 - “...Coumarate reductase An12g02420 5E-43 36 Afu5g09450 3E-57 39 Phenylalanine degradation 2.3.1.18 An13g03730 Anig05994 Galactoside O-acetyltransferase An01g14790 9E-22 44 MG02103 1E-27 50 Carbon metabolism 3.6.3.41 An05g02470 Anig06282 Anig10968 K02021 ABC transport system ATP-binding protein An08g04860 0 33 FG02316 0 30 Transport 5.4.99.- An08g09210 Anig02930 K01865 S-adenosylmethionine tRNA...”
5u2kA / Q5HCZ5 Crystal structure of galactoside o-acetyltransferase complex with coa (h3 space group)
28% identity, 38% coverage
- Ligand: coenzyme a (5u2kA)
Dshi_2161 serine O-acetyltransferase from Dinoroseobacter shibae DFL 12
38% identity, 39% coverage
YP_001555452 WxcM-like protein from Shewanella baltica OS195
28% identity, 50% coverage
- Implication of lateral genetic transfer in the emergence of Aeromonas hydrophila isolates of epidemic outbreaks in channel catfish
Hossain, PloS one 2013 - “...fdtB Shewanella baltica OS195 81 YP_001555451.1 ORF22 24796.25233 dTDP-D-Fucp3N acetyltransferase fdtC Shewanella baltica OS195 85 YP_001555452.1 ORF23 25235.25657 dTDP-6-deoxy-3,4-keto-hexulose isomerase fdtA Shewanella putrefaciens 200 72 ADV52549.1 ORF24 25668.26534 glucose-1-phosphate thymidylyltransferase rmlA Shewanella putrefaciens 200 79 NP_718742 ORF25 26531.27619 dTDP-glucose-4-6-dehydratase rmlB Aeromonas hydrophila 93 AAM22544.1 ORFd 28234.31383...”
- “...fdtB Shewanella baltica OS195 81 YP_001555451 ORF22 24796.25233 dTDP-D-Fucp3N acetyltransferase fdtC Shewanella baltica OS195 85 YP_001555452 ORF23 25235.25657 dTDP-6-deoxy-3,4-keto-hexulose isomerase fdtA Shewanella putrefaciens 200 72 ADV52549 ORF24 25668.26534 glucose-1-phosphate thymidylyltransferase rmlA Shewanella putrefaciens 200 79 ADV52548 ORF25 26531.27619 dTDP-glucose-4-6-dehydratase rmlB Aeromonas hydrophila 93 AAM22544 ORFd 28234.31383...”
sll1636 ferripyochelin binding protein from Synechocystis sp. PCC 6803
35% identity, 50% coverage
- Identification of alcohol stress tolerance genes of Synechocystis sp. PCC 6803 using adaptive laboratory evolution
Matsusako, Biotechnology for biofuels 2017 - “...Ins 389860 CCC CCCC sll1025 Frameshift, stop codon 86 Hypothetical protein Ins 549361 CGG CGGG sll1636 ( fbp ) Frameshift, stop codon 84 Ferripyochelin-binding protein SNP 755131 CTG TTG sll1924 ( sycrp2 ) LeuLeu 99 cAMP receptor protein Ins 1041211 GGG GGGG slr1233 ( frdA )...”
- Identification of the direct regulon of NtcA during early acclimation to nitrogen starvation in the cyanobacterium Synechocystis sp. PCC 6803
Giner-Lamia, Nucleic acids research 2017 - “...the peroxide stress response transcriptional regulator PerR ( slr1738 ), and the LexA repressor ( sll1636 ). Furthermore, many genes coding for metal importer systems were downregulated, such as the ATPases for copper ( ctaA and pacS ), cobalt ( coaT ) and zinc ( ziaA...”
- Loss of the SPHF homologue Slr1768 leads to a catastrophic failure in the maintenance of thylakoid membranes in Synechocystis sp. PCC 6803
Bryan, PloS one 2011 - “...al ., 2003. An analysis of the adjacent ORFs, Sll1638, encoding a hypothetical protein, and Sll1636, which encodes a ferripyochelin binding protein, using the web-tool NNPP, suggests that each have their own promoter and, are likely to be transcribed independently. Hence, insertional inactivation of Slr1768 should...”
P39856 Protein CapG from Staphylococcus aureus
39% identity, 29% coverage
Q46674 N-acetylneuraminate 7-O(or 9-O)-acetyltransferase (EC 2.3.1.45) from Escherichia coli (see paper)
29% identity, 68% coverage
BL1719 probable sugar O-acetyltransferase (thiogalactoside acetyltransferase from Bifidobacterium longum NCC2705
45% identity, 24% coverage
- Investigation of Effects of Novel <i>Bifidobacterium longum</i> ssp. <i>longum</i> on Gastrointestinal Microbiota and Blood Serum Parameters in a Conventional Mouse Model
Rätsep, Microorganisms 2024 - “...7 ]. Recently, we have reported a novel Bifidobacterium longum ssp. longum strain BIOCC 1719 (BL1719) of healthy child origin [ 11 ]. We characterised the metabolic diversity of the strain by determining bioactive compounds like B vitamins, essential amino acids, and fatty acids that the...”
- “...can enrich human nutrition. The aim of this study was to assess the biosafety of BL1719 on a mouse model and to elucidate its potential impact on the gut microbiota and the metabolic profile of the host when administered in live form at a specific dosage....”
- A Novel <i>Bifidobacterium longum</i> ssp. <i>longum</i> Strain with Pleiotropic Effects
Rätsep, Microorganisms 2024 - “...2.1. Origin of the Strain The microorganism Bifidobacterium longum strain BIOCC 1719 (DSM 34239) (hereinafter BL1719) was isolated from a stool sample of a 2-month-old full-term breastfed Estonian child in 2020. The strain was identified by MALDI-TOF MS (Bruker MicroFlex Biotyper, Billerica, MA, USA) as Bifidobacterium...”
- “...analysis. The strain was characterised regarding safety and functional properties (patent pending). 2.2. Screening of BL1719 Metabolites in Different Growth Media 2.2.1. Growth Media and Cultivation Conditions A suspension from the 24 h old BL1719 culture was inoculated in a final inoculation dose of 5.5 log...”
CNC06920 hypothetical protein from Cryptococcus neoformans var. neoformans JEC21
32% identity, 42% coverage
CC2643 bacterial transferase family protein from Caulobacter crescentus CB15
CCNA_02726 putative acetyltransferase/acyltransferase from Caulobacter crescentus NA1000
32% identity, 53% coverage
- Small non-coding RNAs in Caulobacter crescentus
Landt, Molecular microbiology 2008 (secret) - Post-transcriptional gene regulation by an Hfq-independent small RNA in Caulobacter crescentus
Fröhlich, Nucleic acids research 2018 - “...yes CCNA_R0004 133 yes CCNA_00197 CCNA_00196 < < < 3.7 no CCNA_R0063 112 yes CCNA_02725 CCNA_02726 < > < 3.3 no CCNA_R0155 89 yes CCNA_02158 CCNA_02158 > > > internal TSS 3.1 no Figure 1. Transcriptome analysis of C. crescentus in response to DNA damage. (...”
- Cell Cycle Constraints and Environmental Control of Local DNA Hypomethylation in α-Proteobacteria
Ardissone, PLoS genetics 2016 - “...3188019 3188021 2520 1834 CCNA_03032/CCNA_03033 Y 3987164 3987166 2451 489 CCNA_R0199 2889722 2889724 2404 0 CCNA_02726 Y R1, R2 2591862 2591864 2365 124 CCNA_02452 2044585 2044587 2309 1765 CCNA_01902 3592546 3592548 2178 7814 CCNA_03426 1690112 1690114 2126 1239 CCNA_01573/CCNA_01574 902058 902060 2098 6 CCNA_00836 R1, R2...”
- The functions of DNA methylation by CcrM in Caulobacter crescentus: a global approach
Gonzalez, Nucleic acids research 2014 - “...recJ ), CCNA_01651 ( gyrA ), CCNA_02283 (annotated as an endonuclease), CCNA_02389 (UDP-N-acetylglucosamine pyrophosphorylase) and CCNA_02726 (annotated as an acetyltransferase) ( Supplementary Table S4 ). Figure 5. Conserved GANTC motifs are enriched upstream of genes significantly misregulated in the ccrM strain. Frequency, relative to the entire...”
LIC12008 conserved hypothetical protein from Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130
29% identity, 51% coverage
- Prevalence, genetic diversity and eco-epidemiology of pathogenic Leptospira species in small mammal communities in urban parks Lyon city, France
Garcia-Lopez, PloS one 2024 - “...Positive samples belonging to the L . interrogans serogroup Icterohaemorrhagiae were then genotyped using the lic12008 single-locus sequence typing (SLST) described by Santos et al. [ 42 ]. This analysis enabled the distinction between the serovars Copenhageni and Icterohaemorrhagiae. The lic12008 sequences were compared to the...”
- The serological and genetic diversity of the Leptospira interrogans Icterohaemorrhagiae serogroup circulating in the UK
Arent, Journal of veterinary research 2023 - “...were further examined by restriction endonuclease analysis (REA), multiple-locus variable-number tandem repeat analysis (MLVA) and lic12008 gene sequence analysis. Results Monoclonal antibody F12 C3, which is highly specific for Icterohaemorrhagiae and Copenhageni, confirmed that all the strains belonged to these two serovars. Sixteen strains were identified...”
- “...with differences in the repeat number, indicating genetic diversity between British isolates. Sequences of the lic12008 gene showed that all isolates identified as the Icterohaemorrhagiae serotype have a single base insertion, in contrast to the same sequences of the Copenhageni serotype. Conclusion Copenhageni is the predominant...”
- Genetic diversity of Leptospira strains circulating in humans and dogs in France in 2019-2021
Garcia-Lopez, Frontiers in cellular and infection microbiology 2023 - “...etal., 2006 ). Various genes, including the 16S rRNA , lipL32, secY, lfb1 , and lic12008 genes can also be sequenced for the direct genotyping of strains present in biological samples without the need for isolation in culture ( Merien etal., 2005 ; Marquez etal., 2017...”
- Pathogenesis and Genomic Analysis of a Virulent Leptospira Interrogans Serovar Copenhageni Isolated from a Dog with Lethal Infection
de, Tropical medicine and infectious disease 2022 - “...available Copenhageni strains were performed. Characterization based on absence of an INDEL in the gene lic12008, associated with phylogenetic and ANI (99.99% identity) analyses, confirmed the genetic relatedness of the isolate with L. interrogans serovar Copenhageni. A better understanding of the diversity of the pathogenic Leptospira...”
- “...(GCF_002073495.2), as the most closely-related strain. To obtain better serovar discrimination based on genome analysis, lic12008 was tested for the presence of a frameshift mutation, which is present only in Icterohaemorrhagiae strains. The INDEL was absent in the NEG7 isolate, supporting the genetic relatedness of the...”
- Genetic Evidence for a Potential Environmental Pathway to Spillover Infection of Rat-Borne Leptospirosis
Casanovas-Massana, The Journal of infectious diseases 2022 - “...We also amplified by nPCR a fragment of gene lic12008 from 35 environmental samples and all rat specimens as described previously [7] and retrieved the...”
- “...by nPCR a sequenced of a fragment of gene lic12008 from 35 of the 41 environmental samples belonging to cluster A, and all rat specimens. Additionally, we...”
- Detection of New Leptospira Genotypes Infecting Symptomatic Dogs: Is a New Vaccine Formulation Needed?
Bertasio, Pathogens (Basel, Switzerland) 2020 - “...the results obtained by the MAT and/or MLST analysis. 2.4. Sequencing A Tract of the lic12008 Gene on Strains Belonging to ST17 A small tract of the lic12008 genes in 93 samples (both isolates and DNAs) that belonged to ST17 was sequenced for serovar discrimination. In...”
- “...19 isolates, and 8 DNA samples were insufficient for analysis. Interestingly, the serovar identifications by lic12008 sequencing and MAT were in agreement for nine isolates, but not for two isolates that were identified as serovar Copenhageni using the serological method but as serovar Icterohaemorrhagiae using sequencing....”
- Crawling Motility on the Host Tissue Surfaces Is Associated With the Pathogenicity of the Zoonotic Spirochete Leptospira
Xu, Frontiers in microbiology 2020 - “...by multiple loci variable number of tandem repeats analysis (MLVA) and DNA sequencing of the lic12008 gene ( Koizumi et al., 2015 ; Santos et al., 2018 ). Bacteria were cultured in enriched Ellinghausen-McCullough-Johnson-Harris (EMJH) liquid medium (BD Difco, NJ, United States) containing 25 g/mL spectinomycin...”
- Genomic Comparison Among Global Isolates of L. interrogans Serovars Copenhageni and Icterohaemorrhagiae Identified Natural Genetic Variation Caused by an Indel
Santos, Frontiers in cellular and infection microbiology 2018 - “...indel data statistically confirmed the presence of a frameshift mutation within a homopolymeric tract of lic12008 gene (related to LPS biosynthesis) in all the L. interrogans serovar Icterohaemorrhagiae strains but not in the Copenhageni strains. Therefore, this internal indel identified can genetically distinguish L. interrogans serovar...”
- “...R. Identification of internal indel in L. interrogans serovars icterohaemorrhagiae Sanger sequencing confirmed the observed lic12008 mutation using gene specific primers (forward 5TAGGTTGGCACGAAGGTTCT3 and reverse 5TTTTTCCGGGAACTCCAAC3) Sequencher 5.2 (Sequencher Gene Codes Corporation) was used to conduct the sequence analysis, and new sequences were aligned with the...”
PA3853 probable transferase from Pseudomonas aeruginosa PAO1
31% identity, 51% coverage
AWC34_RS01550 CatB-related O-acetyltransferase from Staphylococcus equorum
27% identity, 53% coverage
APL_0588 bifunctional protein GlmU from Actinobacillus pleuropneumoniae L20
A3MZV4 Bifunctional protein GlmU from Actinobacillus pleuropneumoniae serotype 5b (strain L20)
31% identity, 30% coverage
lp_0393 galactoside O-acetyltransferase from Lactobacillus plantarum WCFS1
33% identity, 42% coverage
LSA1867 Putative acetyltransferase, isoleucine patch superfamily from Lactobacillus sakei subsp. sakei 23K
35% identity, 33% coverage
- Global transcriptome response in Lactobacillus sakei during growth on ribose
McLeod, BMC microbiology 2011 - “...Putative zinc-containing alcohol dehydrogenase (oxidoreductase) 1.0 LSA1835 lsa1835 Putative zinc-containing alcohol dehydrogenase (oxidoreductase) -0.7 -1.0 LSA1867 lsa1867 Putative acetyltransferase, isoleucine patch superfamily -0.5 -0.6 -0.7 LSA1871 gshR Glutathione reductase -0.6 Unknown Proteins of unknown function that are similar to other proteins LSA0018 lsa0018 Hypothetical protein 0.5...”
WP_011172737 acyltransferase from Thermus thermophilus
33% identity, 52% coverage
LIMLP_00290 serine O-acetyltransferase from Leptospira interrogans serovar Manilae
Q72W82 serine O-acetyltransferase from Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni (strain Fiocruz L1-130)
Q8F9X5 serine O-acetyltransferase from Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
34% identity, 44% coverage
- Leptospira interrogans biofilm transcriptome highlights adaption to starvation and general stress while maintaining virulence
Davignon, NPJ biofilms and microbiomes 2024 - “...Sulfur and cysteine metabolism genes cysN , cysD , cysH (LIMLP_17220 to LIMLP_17230) and cysE (LIMLP_00290) were upregulated, suggesting the synthesis of essential sulfur components for FeS cluster construction. Conversely, the downregulation of an EamA-like transporter (LIMLP_02205), potentially involved in cysteine and its metabolite export, suggests...”
- The transcriptional response of pathogenic Leptospira to peroxide reveals new defenses against infection-related oxidative stress
Zavala-Alvarado, PLoS pathogens 2020 - “...rh38 NZ_CP011932.1 -1.078 2.65e-08 3208332148 LIMLP_17965 LIMLP_17960 LIMLP_17970 rh81 NZ_CP011931.1 -1.246 3.21e-11 6734967433 NA LIMLP_00285 LIMLP_00290 rh278 NZ_CP011932.1 -1.188 8.73e-13 202039202120 NA LIMLP_18675 LEPIMA_CII0202 rh331 NZ_CP011931.1 -1.137 9.15e-08 245678245742 NA LIMLP_01140 LEPIMA_CI0236 rh411 NZ_CP011931.1 -1.854 1.53e-65 310470310529 NA LIMLP_01410 ** LIMLP_01415 ** rh418 NZ_CP011931.1 -1.395 9.73e-15...”
- In silico identification of common putative drug targets in Leptospira interrogans
Amineni, Journal of chemical biology 2010 - “...Q8F3U3 argC P59307 34 Q72PE4b Sulfur metabolism 35 Q72W82 36 Q72R95 Lysine degradation 37 Q72SS2a 38 Q72UX3b RNA Polymerase 39 Q72NI8 L-lysine 2,3-aminomutase...”
- In silico identification of common putative drug targets in Leptospira interrogans
Amineni, Journal of chemical biology 2010 - “...acetyltransferase Homoserine O-acetyltransferase cysE metX Q8F9X5 Q8F4I0 Serine acetyltransferase Homoserine O-acetyltransferase Q8EXB5 Q8F6T0b L-lysine pbp1...”
CD0872 maltose O-acetyltransferase from Clostridium difficile 630
44% identity, 22% coverage
B9S9Q4 serine O-acetyltransferase from Ricinus communis
34% identity, 25% coverage
4isxA / Q18A66 The crystal structure of maltose o-acetyltransferase from clostridium difficile 630 in complex with acetyl-coa
44% identity, 22% coverage
- Ligand: acetyl coenzyme *a (4isxA)
WD0133 UDP-N-acetylglucosamine pyrophosphorylase from Wolbachia endosymbiont of Drosophila melanogaster
34% identity, 27% coverage
Q5FAE1 UDP-N-acetylbacillosamine N-acetyltransferase (EC 2.3.1.203) from Neisseria gonorrhoeae (see paper)
NGO0085 PglB from Neisseria gonorrhoeae FA 1090
28% identity, 31% coverage
HD1511 Bifunctional GlmU protein from Haemophilus ducreyi 35000HP
31% identity, 30% coverage
CSK29544_02616 NeuD/PglB/VioB family sugar acetyltransferase from Cronobacter sakazakii
32% identity, 49% coverage
- New virulence factor CSK29544_02616 as LpxA binding partner in Cronobacter sakazakii
Kim, Scientific reports 2018 - “...Scientific Reports 2045-2322 Nature Publishing Group UK London 5770445 19306 10.1038/s41598-018-19306-0 Article New virulence factor CSK29544_02616 as LpxA binding partner in Cronobacter sakazakii Kim Seongok 1 2 Yoon Hyunjin yoonh@ajou.ac.kr 2 Ryu Sangryeol sangryu@snu.ac.kr 1 1 0000 0004 0470 5905 grid.31501.36 Department of Food and Animal...”
- “...sakazakii was used to identify new virulence factors. Compared to wild-type bacteria, a mutant lacking CSK29544_02616 (referred to as labp ) was defective in invasion into intestinal epithelial cells (by at least 1000-fold) and showed less phagocytosis by macrophages (by at least 50-fold). The lack of...”
LM6179_0488 bifunctional UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase GlmU from Listeria monocytogenes 6179
36% identity, 25% coverage
Q8YAD4 Bifunctional protein GlmU from Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
lmo0198 highly similar to UDP-N-acetylglucosamine pyrophosphorylase from Listeria monocytogenes EGD-e
36% identity, 25% coverage
PARA_02860 acetyltransferase from Haemophilus parainfluenzae T3T1
28% identity, 49% coverage
- Haemophilus parainfluenzae expresses diverse lipopolysaccharide O-antigens using ABC transporter and Wzy polymerase-dependent mechanisms
Young, International journal of medical microbiology : IJMM 2013 - “...2004 ). Putative nnaA nnaD genes are present within the T3T1 OAg locus ( PARA_02830 PARA_02860 ), sharing high levels of sequence similarity with the genes for polysialic acid capsule biosynthesis in Mannheimia haemolytica serotype A2 strains ( Adlam et al., 1987 ). In addition, PARA_02800...”
- “...The acetylation of the sialic acid residue might be carried out by either NnaD (NeuD; PARA_02860) or the putative O-acetyltransferase PARA_02820. H. influenzae can also decorate its LPS with Neu5Ac, which it obtains from the environment using a tripartite ATP-independent periplasmic (TRAP) transporter encoded by the...”
Rfer_0690 WxcM-like from Rhodoferax ferrireducens DSM 15236
30% identity, 43% coverage
SO1961 maltose O-acetyltransferase from Shewanella oneidensis MR-1
30% identity, 53% coverage
- Probing regulon of ArcA in Shewanella oneidensis MR-1 by integrated genomic analyses
Gao, BMC genomics 2008 - “...2.41 GTTGATTAAAGGTTT Tonb-dependent receptor, putative so1944 1.12 1.80 J 65 - 2.96 GTTAAGTAATTGTAA Hypothetical protein so1961 (maa) 2.96 -1.57 D 114 + 2.63 GTTAGCTAAATGGTA Maltose O-acetyltransferase so2099-7 4.09 2.40 H 147 + 3.29 GTTAATTAAATGTCA Quinone-reactive Ni/Fe hydrogenase, small subunit precursor so2100 1.18 0.63 J 216 -...”
orf5 / A0A0A8J540 UDP-4-amino-4,6-dideoxy-N-acetyl-β-L-idosamine acetyltransferase from Escherichia coli (see paper)
34% identity, 46% coverage
A0KFV9 Maltose O-acetyltransferase from Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / BCRC 13018 / CCUG 14551 / JCM 1027 / KCTC 2358 / NCIMB 9240 / NCTC 8049)
AHA_0602 maltose O-acetyltransferase from Aeromonas hydrophila subsp. hydrophila ATCC 7966
33% identity, 36% coverage
K3G22_10455 serine O-acetyltransferase from Shewanella putrefaciens
29% identity, 44% coverage
PG0002 hexapeptide transferase family protein from Porphyromonas gingivalis W83
PG_0002 acyltransferase from Porphyromonas gingivalis W83
25% identity, 54% coverage
B2RGM6 UDP-2-acetamido-3-amino-2,3-dideoxy-glucuronate N-acetyltransferase (EC 2.3.1.201) from Porphyromonas gingivalis (see paper)
PGN_0002 hypothetical protein from Porphyromonas gingivalis ATCC 33277
25% identity, 54% coverage
- PGN_0297 is an essential component of the type IX secretion system (T9SS) in Porphyromonas gingivalis: Tn-seq analysis for exhaustive identification of T9SS-related genes
Naito, Microbiology and immunology 2019 - “...T9SSrelated genes previously reported Locus No. of Tn mutant clones Gene name Product Reference 1 PGN_0002 5 wbpD Wbp pathway protein WbpD 29 2 PGN_0022 38 porU T9SS component protein PorU 2 3 5intergenic region of PGN_0023 1 porV/pg27/lptO T9SS component protein PorV/Pg27/LptO 18 , 19...”
- Porphyromonas gingivalis and related bacteria: from colonial pigmentation to the type IX secretion system and gliding motility
Nakayama, Journal of periodontal research 2015 - “...Wbp pathway, which involves WbpA (PGN_0613 [UgdA], PGN_1243), WbpB (PGN_0168), WbpE (PGN_1236 [PorR]) and WbpD (PGN_0002), is a sugar substrate required for the biosynthesis of A-LPS ( 38 ). The P. gingivalis strain HG66, typically used for gingipain purification, exhibits no pigmentation on blood agar. This...”
- Involvement of the Wbp pathway in the biosynthesis of Porphyromonas gingivalis lipopolysaccharide with anionic polysaccharide
Shoji, Scientific reports 2014 - “...the WbpA, WbpB, WbpE, WbpD and WbpI proteins. We then determined the effect of the PGN_0002 gene, a wbpD homolog, on the biosynthesis of A-LPS. A PGN_0002-deficient mutant demonstrated an A-LPS biosynthesis deficiency. Taken together with previous studies, the present results suggest that the final product...”
- “...wbpA homologs, wbpB (PGN_0168) was a wbpB homolog, porR (PGN_1236) was a wbpE homolog, and PGN_0002 was a wbpD homolog; no wbpI homologs were found. Our study revealed that the A-LPS deficiency of strain HG66 was the result of a nonsense mutation in the wbpB gene,...”
wckD / Q93NQ3 sialate O-acetyltransferase from Escherichia coli (see 7 papers)
30% identity, 49% coverage
CH51_RS02915 serine O-acetyltransferase from Staphylococcus aureus
Q2G2M7 Serine acetyltransferase from Staphylococcus aureus (strain NCTC 8325 / PS 47)
SAUSA300_0514 serine acetyltransferase from Staphylococcus aureus subsp. aureus USA300_FPR3757
34% identity, 42% coverage
XC_3619 acetyl transferase/isomerase from Xanthomonas campestris pv. campestris str. 8004
28% identity, 45% coverage
- PilG and PilH antagonistically control flagellum-dependent and pili-dependent motility in the phytopathogen Xanthomonas campestris pv. campestris
Qi, BMC microbiology 2020 - “...assay (Fig. 5 c). PilG confirmed directly interaction with XC_0940, XC_1061, XC_1163, XC_1359, XC_2284 and XC_3619. When PilH was tested it showed interactions with XC_1050, XC_3262, XC_1185, XC_1355, XC_1378, XC_3597 and XC_4031. Interestingly, both PilG and PilH proteins interacted with FilN by using bacterial two hybrid...”
- “...the MS-coupled co-IP experiments. We found that PilG could interact with PilN, PilR, PilU, CheA, XC_3619 and XC_1163. While PilH interacted with PilI, ColS, PhoP, XC_1355, XC_1378, XC_3262 and XC_3597. Importantly, our previous work has shown that mutation of genes encoding PilN (XC_0940), PilU (XC_1359), PilR...”
SA0487 hypothetical protein from Staphylococcus aureus subsp. aureus N315
34% identity, 42% coverage
Q6IWF9 serine O-acetyltransferase (EC 2.3.1.30) from Noccaea goesingensis (see paper)
35% identity, 30% coverage
ZPR_0548 galactoside acetyltransferase (lacA) from Zunongwangia profunda SM-A87
30% identity, 45% coverage
DIP1891 serine O-acetyltransferase EpsC from Corynebacterium diphtheriae NCTC 13129
37% identity, 40% coverage
FQU82_00141 DapH/DapD/GlmU-related protein from Acinetobacter baumannii
51% identity, 21% coverage
LMOf2365_0209 UDP-N-acetylglucosamine pyrophosphorylase from Listeria monocytogenes str. 4b F2365
35% identity, 25% coverage
- Transcriptomic Analysis of Listeria monocytogenes in Response to Bile Under Aerobic and Anaerobic Conditions
Chakravarty, Frontiers in microbiology 2021 - “...oxidase subunit II, Oxidative phosphorylation 5.5 gabD LMOf2365_0935 Succinate-semialdehyde dehydrogenase 5.4 LMOf2365_2364 Ferredoxin/flavodoxinNADP+ reductase 5.3 LMOf2365_0209 UDP-N-acetylglucosamine pyrophosphorylase 4.9 guaB LMOf2365_2746 Inosine-5-monophosphate dehydrogenase 4.3 LMOf2365_0566 Putative N-carbamoyl-L-amino acid amidohydrolase 4.1 ctaB LMOf2365_2088 Heme o synthase 4.1 prs-1 LMOf2365_0210 Ribose-phosphate pyrophosphokinase 3.9 LMOf2365_1048 Metallo-beta-lactamase family protein 3.6...”
VCA0836 hexapeptide-repeat containing-acetyltransferase from Vibrio cholerae O1 biovar eltor str. N16961
32% identity, 38% coverage
LMOSA_10910 bifunctional UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase GlmU from Listeria monocytogenes str. Scott A
35% identity, 25% coverage
stu1099 exopolysaccharide biosynthesis protein from Streptococcus thermophilus LMG 18311
28% identity, 64% coverage
C1O30_RS13310 NeuD/PglB/VioB family sugar acetyltransferase from Dickeya zeae
28% identity, 50% coverage
EHI_039180 acetyltransferase, putative from Entamoeba histolytica HM-1:IMSS
30% identity, 39% coverage
NP_347413 Acetyltransferase (the isoleucine patch superfamily) from Clostridium acetobutylicum ATCC 824
49% identity, 20% coverage
- Rickettsia phylogenomics: unwinding the intricacies of obligate intracellular life
Gillespie, PloS one 2008 - “...QCD-32g58; HP CdifQ_04002574 50.1 3.00E-05 NP_246134 Pasteurella multocida subsp. multocida str. Pm70; VatB 50.1 3.00E-05 NP_347413 Clostridium acetobutylicum ATCC 824; Acetyltransferase (the Ile patch superfamily) 50.1 4.00E-05 YP_083964 Bacillus cereus E33L; virginiamycin A acetyltransferase 50.1 4.00E-05 YP_734654 Shewanella sp. MR-4; streptogramin A acetyl transferase 50.1 4.00E-05...”
CYSE_BACSU / Q06750 Serine acetyltransferase; SAT; EC 2.3.1.30 from Bacillus subtilis (strain 168) (see paper)
29% identity, 49% coverage
- function: Catalyzes the acetylation of serine by acetyl-CoA to produce O-acetylserine (OAS)
catalytic activity: L-serine + acetyl-CoA = O-acetyl-L-serine + CoA (RHEA:24560)
3nz2J / Q9KLB0 Crystal structure of hexapeptide-repeat containing-acetyltransferase vca0836 complexed with acetyl co enzyme a from vibrio cholerae o1 biovar eltor
32% identity, 37% coverage
- Ligand: acetyl coenzyme *a (3nz2J)
KP1_3712 galactoside O-acetyltransferase from Klebsiella pneumoniae NTUH-K2044
33% identity, 51% coverage
ZMO1806 Maltose O-acetyltransferase from Zymomonas mobilis subsp. mobilis ZM4
32% identity, 54% coverage
BBW69_05440 NeuD/PglB/VioB family sugar acetyltransferase from Neisseria sp. RH3002v2f
27% identity, 31% coverage
CAP2UW1_2752 phenylacetic acid degradation protein PaaY from Candidatus Accumulibacter phosphatis clade IIA str. UW-1
31% identity, 55% coverage
- Metatranscriptomic insights on gene expression and regulatory controls in Candidatus Accumulibacter phosphatis
Oyserman, The ISME journal 2016 - “...( Heinhorst et al. , 2006 ). Other carbonic anhydrases are also expressed (CAP2UW1_1300, CAP2UW1_4260, CAP2UW1_2752, CAP2UW1_3656, CAP2UW1_4334, CAP2UW1_1398, CAP2UW1_1977, CAP2UW1_2924) and show varying expression profiles. However, only CAP2UW1_1967 is highly expressed, dynamic and within the AAC. The biological relevance of carbonic anhydrase in Accumulibacter is...”
P23145 Probable serine acetyltransferase from Azotobacter chroococcum mcd 1
33% identity, 47% coverage
SAT1-a / Q39218 serine acetyltransferase (EC 2.3.1.30) from Arabidopsis thaliana (see 4 papers)
SAT3_ARATH / Q39218 Serine acetyltransferase 3, mitochondrial; AtSAT-3; AtSERAT2;2; SAT-m; EC 2.3.1.30 from Arabidopsis thaliana (Mouse-ear cress) (see 7 papers)
Q39218 serine O-acetyltransferase (EC 2.3.1.30) from Arabidopsis thaliana (see 4 papers)
AT3G13110 ATSERAT2;2 (SERINE ACETYLTRANSFERASE 2;2); serine O-acetyltransferase from Arabidopsis thaliana
NP_187918 serine acetyltransferase 2;2 from Arabidopsis thaliana
34% identity, 25% coverage
- catalytic activity: L-serine + acetyl-CoA = O-acetyl-L-serine + CoA (RHEA:24560)
subunit: Homomultimer (By similarity). Interacts with OASC. Component of the cysteine synthase complex (CSC) composed of two OAS-TL dimers and one SAT hexamer. - Stress responses of plants through transcriptome plasticity by mRNA alternative polyadenylation
Zhou, Molecular horticulture 2023 - “...Arabidopsis , a novel iso-seq based transcriptome study found that cold induced gene AT1G11280 and AT3G13110 switched to use proximal poly(A) sites while gene AT5G5320 switched to use a distal poly(A) site, and they all increased expression level and had a dramatically expression peak in thenight...”
- “...HSP21, HSP70, HSP70-3, HSP40, HSP101, HSP17.6II, HSP17.6C, AT1G59860, AT4G12400, AT3G09350, AT4G36040 Cold / proximal AT1G11280, AT3G13110 (Zhang et al. 2022 ) distal AT5G53420 Table 2 Dynamic features of plant APA genes related to biotic stress responses Biotic Stress Species Stress resistance related Phenotype changing related Reference...”
- New insights into the regulation of plant metabolism by O-acetylserine: sulfate and beyond
Apodiakou, Journal of experimental botany 2023 - “...). In Arabidopsis five genes encoding SERAT proteins can be found: SERAT2;1 (AT1G55920) and SERAT2;2 (AT3G13110), which are localized in plastids and mitochondria, respectively, and SERAT1;1 (AT5G56760), SERAT3;1 (AT2G17640), and SERAT3;2 (AT4G35640), which are localized and expressed in the cytosol ( Watanabe et al. , 2008...”
- “...2 ; Table 1 ). Of the five SERAT genes, SERAT1;1 (At5g56760), SERAT2;1 (At1g55920), SERAT2;2 (At3g13110), SERAT3;1 (At2g17640), and SERAT3;2 (At4g35640), each has a different transcriptional response to certain conditions ( Watanabe and Hoefgen, 2017 ). It was shown that SERAT group III genes are highly...”
- Photorespiration: regulation and new insights on the potential role of persulfidation
Aroca, Journal of experimental botany 2023 - “...synthase mitochondrial P (3,4) , S (5,7) AT2G17640 Q8S895 SAT2 Serine acetyltransferase 2 P (3) AT3G13110 Q39218 SAT3 Serine acetyltransferase 3, mitochondrial P (3) , S (5,7) AT5G56760 Q42538 SAT5 Serine acetyltransferase 5 P (3) AT5G04590 Q9LZ66 SIR Assimilatory sulfite reductase (ferredoxin) chloroplastic P (3,4) ,...”
- A high-resolution single-molecule sequencing-based Arabidopsis transcriptome using novel methods of Iso-seq analysis
Zhang, Genome biology 2022 - “....11 transcript does not change significantly in response to light-dark or cold (Fig. 6 A). AT3G13110 is a single-exon gene. The .1 and .2 isoforms have the same poly(A) sites but the TSS of .2 is 272bp upstream of .1. The .2 transcript codes for a...”
- Glutathione degradation activity of γ-glutamyl peptidase 1 manifests its dual roles in primary and secondary sulfur metabolism in Arabidopsis
Ito, The Plant journal : for cell and molecular biology 2022 - “..., AT4G39940), ATP sulfurylase 3 ( APS3 , AT4G14680), and serine acetyltransferase2;2 ( SERAT2;2 , AT3G13110). Our metabolome data also support the hypothesis of the dual roles of GGPs (Figure 4 ). As discussed in the previous section, many GSLs and ITCs showed significant decreases or...”
- Chemical Priming by Isothiocyanates Protects Against Intoxication by Products of the Mustard Oil Bomb
Ferber, Frontiers in plant science 2020 - “...enzymes of the serine acetyltransferase (SAT) gene family: SERAT1;1 (At5g56760, SAT-c), SERAT2;1 (At1g55920, SAT-p), SERAT2;2 (At3g13110, SAT-m), SERAT3;1 (At2g17640, SAT-106) and SERAT3;2 (At4g35640). Except for SERAT2;1 which was found to be induced by 1.6-fold by SF 4 h after treatment, none of these genes appeared to...”
- The Effect of Single and Multiple SERAT Mutants on Serine and Sulfur Metabolism
Watanabe, Frontiers in plant science 2018 - “...SERAT gene family. Gene name AGI code Localization SERAT1;1 At5g56760 Cytosol SERAT2;1 At1g55920 Plastids SERAT2;2 At3g13110 Mitochondria SERAT3;1 At2g17640 Cytosol SERAT3;2 At4g45640 Cytosol Despite of the fact that OAS and cysteine are synthesized in multiple subcellular compartments, Arabidopsis knockout mutants lacking one or retaining only one...”
- Genome-wide analysis of overlapping genes regulated by iron deficiency and phosphate starvation reveals new interactions in Arabidopsis roots
Li, BMC research notes 2015 - “...protein 1.55 0.27 2.13 0.21 At1G05300 ZIP5, zinc transporter 5 precursor 0.49 0.05 2.13 0.11 At3G13110 ATSERAT2;2, SAT-1, SAT-A, SAT-M, SAT3, SERAT2;2, serine acetyltransferase 2;2 0.83 0.08 2.12 0.22 At2G22290 ATRAB-H1D, ATRAB6, ATRABH1D, RAB-H1D, RABH1d, RAB GTPase homolog H1D 1.91 0.66 2.10 0.59 At4G20160 RING/U-box superfamily...”
- More
- Mitochondrial serine acetyltransferase functions as a pacemaker of cysteine synthesis in plant cells.
Haas, Plant physiology 2008 - GeneRIF: Mitochondrial serine acetyltransferase regulates the production of O-acetylserine in the mitochondria, which affects cysteine synthesis.
- Comparative genomics and reverse genetics analysis reveal indispensable functions of the serine acetyltransferase gene family in Arabidopsis.
Watanabe, The Plant cell 2008 - GeneRIF: Mitochondrial SERAT2;2 plays a predominant role in cellular OAS formation.
- In silico assessment of gene function involved in cysteine biosynthesis in Arabidopsis: expression analysis of multiple isoforms of serine acetyltransferase.
Noji, Amino acids 2006 (PubMed)- GeneRIF: From the results of sensitivity to feedback regulation, subcellular localization and expression of mRNA analyses, each serine acetyltransferase (SATase) isoform seems to have its specific role for cysteine biosynthesis.
- Photorespiration: regulation and new insights on the potential role of persulfidation
Aroca, Journal of experimental botany 2023 - “...mitochondrial P (3,4) , S (5,7) AT2G17640 Q8S895 SAT2 Serine acetyltransferase 2 P (3) AT3G13110 Q39218 SAT3 Serine acetyltransferase 3, mitochondrial P (3) , S (5,7) AT5G56760 Q42538 SAT5 Serine acetyltransferase 5 P (3) AT5G04590 Q9LZ66 SIR Assimilatory sulfite reductase (ferredoxin) chloroplastic P (3,4) , S...”
A9IH93 UDP-2-acetamido-3-amino-2,3-dideoxy-glucuronate N-acetyltransferase (EC 2.3.1.201) from Bordetella petrii (see paper)
30% identity, 52% coverage
FNP_1107 acetyltransferase from Fusobacterium polymorphum ATCC 10953
29% identity, 48% coverage
- Ubiquitous sialometabolism present among oral fusobacteria
Yoneda, PloS one 2014 - “...and Lipase DGSL2 family (NeuA) CMP-Neu5Ac synthesis FNP_1106 NeuB family; SAF domain (NeuB) Neu5Ac synthesis FNP_1107 Bacterial transferase hexapeptide; sialic acid O-acetyltransferase (NeuD) Neu5Ac synthesis/modification ssp. vincentii * FNV1764 UDP-N-acetylglucosamine 2-epimerase (NeuC) ManNAc synthesis FNV1765 CTP transferase 3 and Lipase DGSL2 family (NeuA) CMP-Neu5Ac synthesis FNV1766...”
- “...novo sialic acid synthesis capabilities. These three organisms also encode putative neuD sialic acid O-acetyltransferases (FNP_1107, FNV1767, and FPOG_00225) that are likely involved in adding O-acetylation to the sialic acid molecules [43] , [44] . This activity appears to be missing from the ssp. nucleatum neu...”
- Genome sequence of Fusobacterium nucleatum subspecies polymorphum - a genetically tractable fusobacterium
Karpathy, PloS one 2007 - “...FNP_1105 1446154 1444898 neuA CMP-N-acetylneuraminate cytidylyltransferase FNP_1106 1447200 1446157 neuB possible N-acetyl neuramic acid synthetase FNP_1107 1447822 1447205 N-acetylneuraminate synthase FNP_1108 1449226 1447934 oligosaccharidyl-lipid/polysaccharide flippase FNP_1109 1450280 1449300 possible lipooligosaccharide sialyltransferase FNP_1205 1556498 1557478 waaE possible ADP-heptose synthase FNP_1807 2161658 2162707 waaF2 LPS heptosyltransferase II FNP_1808...”
3bssA / Q0P9D1 Pgld from campylobacter jejuni, nctc 11168, with native substrate (see paper)
25% identity, 66% coverage
- Ligand: udp-2-acetamido-4-amino-2,4,6-trideoxy-alpha-d-glucopyranose (3bssA)
3mqgC / A9IH93 Crystal structure of the 3-n-acetyl transferase wlbb from bordetella petrii in complex with acetyl-coa (see paper)
30% identity, 52% coverage
- Ligands: uridine-5'-monophosphate; acetyl coenzyme *a; uridine-5'-diphosphate (3mqgC)
cg2834 Serine O-acetyltransferase from Corynebacterium glutamicum ATCC 13032
35% identity, 47% coverage
Q6IWF8 serine O-acetyltransferase (EC 2.3.1.30) from Noccaea goesingensis (see paper)
35% identity, 32% coverage
ZP_01613073 streptogramin A acetyl transferase from Alteromonadales bacterium TW-7
44% identity, 23% coverage
- Rickettsia phylogenomics: unwinding the intricacies of obligate intracellular life
Gillespie, PloS one 2008 - “...hexapeptide repeat containing protein 54.3 2.00E-06 ZP_01186630 Bacillus weihenstephanensis KBAB4; transferase hexapeptide repeat 54.3 2.00E-06 ZP_01613073 Alteromonadales bacterium TW-7; streptogramin A acetyl transferase 53.9 2.00E-06 YP_927261 Shewanella amazonensis SB2B; streptogramin A acetyl transferase 53.9 2.00E-06 YP_171536 Synechococcus elongatus PCC 6301; acetyltransferase 53.9 3.00E-06 NP_978962 Bacillus cereus...”
BAU10_18400 sugar O-acetyltransferase from Vibrio alginolyticus
32% identity, 48% coverage
- Identification of a Novel Small RNA srvg23535 in Vibrio alginolyticus ZJ-T and Its Characterization With Phenotype MicroArray Technology
Deng, Frontiers in microbiology 2018 - “...system transcriptional repressor K03567//glycine cleavage system transcriptional repressor BAU10_10195 cheZ Protein phosphatase K03414//chemotaxis protein CheZ BAU10_18400 maa Maltose acetyltransferase K00661//maltose O -acetyltransferase [EC:2.3.1.79] BAU10_22015 kdpD Histidine kinase K07646//two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3] BAU10_16085 opsX Glycosyl transferase K12982//heptosyltransferase I [EC:2.4.-.-] BAU10_19325 Flavodoxin BAU10_03555...”
- “...or/and the degradation of these carbon sources. However, only a maltose acetyltransferase coding gene maa (BAU10_18400) was predicated as the common target involved in carbon metabolism. The mutant gained growth sharply after 3 days when the bacteria were cultured with L -cysteine as a nitrogen source,...”
LLKF_2165 galactoside O-acetyltransferase from Lactococcus lactis subsp. lactis KF147
29% identity, 46% coverage
SK271_1557 DapH/DapD/GlmU-related protein from Streptococcus mitis
40% identity, 23% coverage
pglD / Q0P9D1 UDP-4-amino-4,6-dideoxy-α-D-N-acetyl-D-glucosamine N-acetyltransferase subunit (EC 2.3.1.203) from Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168) (see 3 papers)
PGLD_CAMJE / Q0P9D1 UDP-N-acetylbacillosamine N-acetyltransferase; Protein glycosylation D; UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine N-acetyltransferase; EC 2.3.1.203 from Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168) (see 4 papers)
Q0P9D1 UDP-N-acetylbacillosamine N-acetyltransferase (EC 2.3.1.203) from Campylobacter jejuni subsp. jejuni (see paper)
Cj1123c putative transferase from Campylobacter jejuni subsp. jejuni NCTC 11168
25% identity, 67% coverage
- function: Acetyltransferase that modifies the UDP-4-amino-sugar to form UDP-N,N'-diacetylbacillosamine in the N-linked protein glycosylation pathway.
catalytic activity: UDP-N-acetylbacillosamine + acetyl-CoA = UDP-N,N'- diacetylbacillosamine + CoA + H(+) (RHEA:34159)
subunit: Homotrimer. - Tannerella forsythia strains display different cell-surface nonulosonic acids: biosynthetic pathway characterization and first insight into biological implications
Friedrich, Glycobiology 2017 - “...jejuni legC (Cj1320) 49 385 Aminotransferase Schoenhofen et al. (2009) BFO_1067 a C. jejuni pglD (Cj1123c) 30 83 N -acetyltransferase Olivier et al. (2006) , Schoenhofen et al. (2009) BFO_1065 C. jejuni legG (Cj1328) 46 350 NDP-sugar hydrolase/2-epimerase Member of NDP- N -acetylglucosamine 2-epimerase family (PFAM)...”
- The renaissance of bacillosamine and its derivatives: pathway characterization and implications in pathogenicity
Morrison, Biochemistry 2014 - “...depicted with dashed lines. The final step of UDP-diNAcBac biosynthesis relies on the acetyltransferase PglD (Cj1123c), which acetylates the UDP-4-amino sugar in an acetyl coenzyme A (AcCoA)-dependent reaction. Catalysis involves an active site histidine that acts as a general base to abstract a proton from the...”
- “...Chem. 288 , 32248 32260 . 24064219 Demendi M. ; Creuzenet C. ( 2009 ) Cj1123c (PglD), a multifaceted acetyltransferase from Campylobacter jejuni . Biochem. Cell Biol. 87 , 469 483 . 19448740 Olivier N. B. ; Imperiali B. ( 2008 ) Crystal structure and catalytic...”
- Cj1123c (PglD), a multifaceted acetyltransferase from Campylobacter jejuni
Demendi, Biochemistry and cell biology = Biochimie et biologie cellulaire 2009 (PubMed)- “...Cj1123c (PglD), a multifaceted acetyltransferase from Campylobacter jejuni Melinda Demendi and Carole Creuzenet Abstract: Campylobacter jejuni produces both N- and O-glycosylated proteins. Because protein glycosylation contributes to bacterial virulence, a thorough characterization of...”
- “...of the substrate and acyl-donor specificities of Cj1123c (also known as PglD), an acetyltransferase of the HexAT superfamily involved in N-glycosylation...”
- Identification of Campylobacter jejuni genes contributing to acid adaptation by transcriptional profiling and genome-wide mutagenesis
Reid, Applied and environmental microbiology 2008 - “...against nitrosative stress (Cj1586), N-linked protein glycosylation (Cj1123c and pglD), and chemotaxis (Cj0262c). This group also includes genes encoding...”
- In vitro biosynthesis of UDP-N,N'-diacetylbacillosamine by enzymes of the Campylobacter jejuni general protein glycosylation system
Olivier, Biochemistry 2006 - “...at the C4 position of the UDP-4-amino-sugar by Cj1123c (PglD). The native dehydratase PglF has three domains: an N-terminal transmembrane domain, a Cterminal...”
A0A0C5DAX6 serine O-acetyltransferase (EC 2.3.1.30) from Vitis vinifera (see paper)
34% identity, 26% coverage
Q6IWG0 serine O-acetyltransferase (EC 2.3.1.30) from Noccaea goesingensis (see paper)
34% identity, 24% coverage
IV454_00155, IV454_32525 gamma carbonic anhydrase family protein from Massilia antarctica
34% identity, 51% coverage
- Characterisation of Waterborne Psychrophilic Massilia Isolates with Violacein Production and Description of Massilia antarctica sp. nov
Sedláček, Microorganisms 2022 - “...among the known genes. However, two copies of a putative cat B2 gene (locus tags IV454_00155 and IV454_32525) coding for chloramphenicol acetyltransferases were found among the loose hits, both with 38.1% sequence identity to the best hit. Since experimental work has demonstrated the strains resistance to...”
- “...known genes. However, two copies of a putative cat B2 gene (locus tags IV454_00155 and IV454_32525) coding for chloramphenicol acetyltransferases were found among the loose hits, both with 38.1% sequence identity to the best hit. Since experimental work has demonstrated the strains resistance to chloramphenicol, it...”
AB57_3844 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase from Acinetobacter baumannii AB0057
33% identity, 26% coverage
- Variation in the complex carbohydrate biosynthesis loci of Acinetobacter baumannii genomes
Kenyon, PloS one 2013 - “...GlmM, GlmU, Gne, and Wzi are found in the at locus tags AB57_3633, AB57_3845, AB57_3769, AB57_3844, AB57_2335, and AB57_1078 respectively. Synthesis of both capsular and O-antigen polysaccharides begins with the synthesis of the repeat unit in the cytoplasm. A pre-formed sugar precursor is transferred to the...”
- “...Figure 1 ). The glmS , glmM and glmU genes [locus tags AB57_3845, AB57_3769, and AB57_3844 respectively in CP001182] are required for the synthesis of UDP-D-Glc p NAc. Another gene [locus tag AB57_2335 in CP001182] predicts a protein with 36% identity to Gne from Vibrio vulnificus...”
LOC110751150 serine acetyltransferase 5 from Prunus avium
35% identity, 34% coverage
- Application of proteomics to determine the mechanism of ozone on sweet cherries (Prunus avium L.) by time-series analysis
Zhao, Frontiers in plant science 2023 - “...QUALITY PROTEIN: pyruvate kinase isozyme A, chloroplastic-like -0.78 LOC110773697 A0A6P5U464 serine acetyltransferase 1, chloroplastic-like -0.65 LOC110751150 A0A6P5S1I7 serine acetyltransferase 5 0.89 LOC110768684 A0A6P5TMK4 uncharacterized protein LOC110768684 -0.67 LOC110753532 A0A6P5S8M0 fructose-bisphosphate aldolase 1, cytoplasmic -0.69 LOC110762488 A0A6P5SVE9 cytosolic enolase 3 -0.70 LOC110758653 A0A6P5SRD7 3-dehydroquinate synthase, chloroplastic -0.61...”
- “...4, chloroplastic -0.70 LOC110773146 A0A6P5U2L1 S-formylglutathione hydrolase -0.61 LOC110773697 A0A6P5U464 serine acetyltransferase 1, chloroplastic-like -0.65 LOC110751150 A0A6P5S1I7 serine acetyltransferase 5 0.89 LOC110768684 A0A6P5TMK4 uncharacterized protein LOC110768684 -0.67 LOC110753532 A0A6P5S8M0 fructose-bisphosphate aldolase 1, cytoplasmic -0.69 LOC110762488 A0A6P5SVE9 cytosolic enolase 3 -0.70 LOC110752818 A0A6P5S118 dihydrolipoyllysine-residue succinyltransferase component of...”
ABUW_0090 bifunctional UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase GlmU from Acinetobacter baumannii
33% identity, 25% coverage
LOC110773697 serine acetyltransferase 1, chloroplastic-like from Prunus avium
A0A6P5U464 serine O-acetyltransferase from Prunus avium
32% identity, 25% coverage
- Application of proteomics to determine the mechanism of ozone on sweet cherries (Prunus avium L.) by time-series analysis
Zhao, Frontiers in plant science 2023 - “...synthase alpha chain -1.22 LOC110760963 A0A6P5SZC9 LOW QUALITY PROTEIN: pyruvate kinase isozyme A, chloroplastic-like -0.78 LOC110773697 A0A6P5U464 serine acetyltransferase 1, chloroplastic-like -0.65 LOC110751150 A0A6P5S1I7 serine acetyltransferase 5 0.89 LOC110768684 A0A6P5TMK4 uncharacterized protein LOC110768684 -0.67 LOC110753532 A0A6P5S8M0 fructose-bisphosphate aldolase 1, cytoplasmic -0.69 LOC110762488 A0A6P5SVE9 cytosolic enolase 3...”
- “...A, chloroplastic-like -0.78 LOC110749634 A0A6P5RR27 probable 6-phosphogluconolactonase 4, chloroplastic -0.70 LOC110773146 A0A6P5U2L1 S-formylglutathione hydrolase -0.61 LOC110773697 A0A6P5U464 serine acetyltransferase 1, chloroplastic-like -0.65 LOC110751150 A0A6P5S1I7 serine acetyltransferase 5 0.89 LOC110768684 A0A6P5TMK4 uncharacterized protein LOC110768684 -0.67 LOC110753532 A0A6P5S8M0 fructose-bisphosphate aldolase 1, cytoplasmic -0.69 LOC110762488 A0A6P5SVE9 cytosolic enolase 3...”
- Application of proteomics to determine the mechanism of ozone on sweet cherries (Prunus avium L.) by time-series analysis
Zhao, Frontiers in plant science 2023 - “...alpha chain -1.22 LOC110760963 A0A6P5SZC9 LOW QUALITY PROTEIN: pyruvate kinase isozyme A, chloroplastic-like -0.78 LOC110773697 A0A6P5U464 serine acetyltransferase 1, chloroplastic-like -0.65 LOC110751150 A0A6P5S1I7 serine acetyltransferase 5 0.89 LOC110768684 A0A6P5TMK4 uncharacterized protein LOC110768684 -0.67 LOC110753532 A0A6P5S8M0 fructose-bisphosphate aldolase 1, cytoplasmic -0.69 LOC110762488 A0A6P5SVE9 cytosolic enolase 3 -0.70...”
- “...chloroplastic-like -0.78 LOC110749634 A0A6P5RR27 probable 6-phosphogluconolactonase 4, chloroplastic -0.70 LOC110773146 A0A6P5U2L1 S-formylglutathione hydrolase -0.61 LOC110773697 A0A6P5U464 serine acetyltransferase 1, chloroplastic-like -0.65 LOC110751150 A0A6P5S1I7 serine acetyltransferase 5 0.89 LOC110768684 A0A6P5TMK4 uncharacterized protein LOC110768684 -0.67 LOC110753532 A0A6P5S8M0 fructose-bisphosphate aldolase 1, cytoplasmic -0.69 LOC110762488 A0A6P5SVE9 cytosolic enolase 3 -0.70...”
KBNAB1_0725 CatB-related O-acetyltransferase from Acinetobacter baumannii
ABAYE0798 chloramphenicol acetyltransferase from Acinetobacter baumannii AYE
48% identity, 19% coverage
- Complete genome of the multidrug-resistant Acinetobacter baumannii strain KBN10P02143 isolated from Korea
Lee, Memorias do Instituto Oswaldo Cruz 2016 - “...streptomycin 3-adenylyltransferase (KBNAB1_1343, KBNAB1_2641), dihydropteroate synthase (KBNAB1_2639 for sulfonamide resistance), dihydrofolate reductase (KBNAB1_3423), chloramphenicol acetyltransferase (KBNAB1_0725, KBNAB1_1342), macrolide 2-phosphotransferase (KBNAB1_1352) and macrolide efflux protein (KBNAB1_1351). The presence of these genes shows that the strain would be capable of overcoming the stimuli induced by diverse antibiotics (...”
- Genomic analysis of Acinetobacter baumannii A118 by comparison of optical maps: identification of structures related to its susceptibility phenotype
Ramirez, Antimicrobial agents and chemotherapy 2011 - “...other A. baumannii strains (strain AYE, locus tag ABAYE0798; strain AB0057, locus tag AB57_3104; strain ATCC 17978, locus tag A1S_2691) (Fig. 2b). These results...”
- “...acetyltransferase amino acid sequences. Strain AYE, locus tag ABAYE0798; strain AB0057, locus tag AB57_3104; strain ATCC 17978, locus tag A1S_2691. VOL. 55,...”
A1S_0057 capsular polysaccharide synthesis enzyme from Acinetobacter baumannii ATCC 17978
51% identity, 21% coverage
fdtC / Q6T1W7 dTDP-3-amino-3,6-dideoxy-α-D-galactopyranose 3-N-acetyltransferase (EC 2.3.1.197) from Aneurinibacillus thermoaerophilus (see 2 papers)
FDTC_ANETH / Q6T1W7 dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose 3-N-acetyltransferase; dTDP-D-Fucp3N acetylase; EC 2.3.1.197 from Aneurinibacillus thermoaerophilus (see paper)
Q6T1W7 dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose 3-N-acetyltransferase (EC 2.3.1.197) from Aneurinibacillus thermoaerophilus (see paper)
27% identity, 58% coverage
- function: Catalyzes the transfer of an acetyl group to dTDP-D-Fucp3N to form dTDP-D-Fucp3NAc in the biosynthesis of dTDP-3-acetamido-3,6- dideoxy-alpha-D-galactose, a glycan chain of the S-layer.
catalytic activity: dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose + acetyl-CoA = dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactopyranose + CoA + H(+) (RHEA:32095)
ABLAC_08080 CatB-related O-acetyltransferase from Acinetobacter baumannii LAC-4
48% identity, 19% coverage
PP1454 anhydrase, family 3 protein from Pseudomonas putida KT2440
33% identity, 52% coverage
CCNA_02734 serine acetyltransferase from Caulobacter crescentus NA1000
39% identity, 34% coverage
Q7DD76 Pilin glycosylation protein PglB from Neisseria meningitidis serogroup B (strain ATCC BAA-335 / MC58)
Q9RR58 PglB from Neisseria meningitidis
NMB1820 pilin glycosylation protein PglB from Neisseria meningitidis MC58
24% identity, 33% coverage
- Glycoconjugate pathway connections revealed by sequence similarity network analysis of the monotopic phosphoglycosyl transferases
O'Toole, Proceedings of the National Academy of Sciences of the United States of America 2021 (secret) - Genomic and phenotypic comparison of Prevotella intermedia strains possessing different virulence in vivo
Kwack, Virulence 2022 - “...C. jejuni PglC (O86156); Helicobacter pullorum PglC (E1B268); Neisseria. gonorrhoeae PglB (A0A1D3HQ90); N. meningitidis PglB (Q9RR58); Pseudomonas putida Sugar transferase (A0A0P7CW64). Multiple sequence alignment of the phosphoglycosyl transferase family protein sequences with PGTs from P. intermedia were performed using ClustalW tool. The phylogenetic tree was built...”
- Interplay Between Virulence and Variability Factors as a Potential Driver of Invasive Meningococcal Disease
Siena, Computational and structural biotechnology journal 2018 - “...Pilin glycosylation Adherence pglA NMB0218 Yes [ 43 , 54 ] Pilin glycosylation Adherence pglB NMB1820 Pilin glycosylation Adherence pglC NMB1821 Pilin glycosylation Adherence pglD NMB1822 Quinolinate synthetase Adherence NEIS1772 NMB0394 Type IV pili Adherence pilC NMB0049 Yes [ 15 , 43 , 54 , 55...”
- Transcriptomic buffering of cryptic genetic variation contributes to meningococcal virulence
Ampattu, BMC genomics 2017 - “...n.s. 2.18 1.74 NMB1811 pilP PilP protein n.s. 0.86 n.s. n.s. n.s. n.s. n.s. n.s. NMB1820 pglB Pilin glycosylation protein PglB 1.69 n.s. n.s. n.s. 1.46 n.s. n.s. n.s. NMB1821 pglC Pilin glycosylation protein PglC 1.73 n.s. n.s. n.s. n.s. n.s. n.s. n.s. Efflux pumps NMB0318...”
- Attachment and invasion of Neisseria meningitidis to host cells is related to surface hydrophobicity, bacterial cell size and capsule
Bartley, PloS one 2013 - “...No (I) No (II) PglA NMB0218 Pilin glycan galactose transferase [82] Yes Yes +++ PglB NMB1820 Pilin glycan synthesis [82] No No PglE NMB0624 Pilin glycan galactose transferase [82] Yes Yes +++ PglG NMC0401 Pilin glycan glucose transferase [103] Absent Yes +++ PglH NMC0400 Pilin glycan...”
GSU1973 hexapeptide transferase family protein from Geobacter sulfurreducens PCA
30% identity, 48% coverage
BT3870 putative maltose O-acetyltransferase from Bacteroides thetaiotaomicron VPI-5482
29% identity, 38% coverage
WP_000469854 acyltransferase from Escherichia coli
28% identity, 47% coverage
FPOG_00225 N-acetylneuraminate synthase from Fusobacterium periodonticum D10
28% identity, 24% coverage
- Ubiquitous sialometabolism present among oral fusobacteria
Yoneda, PloS one 2014 - “...sialic acid O-acetyltransferase (NeuB/D) Neu5Ac synthesis/modification FNV1768 CTP transferase 3 (NeuA) CMP-Neu5Ac synthesis F. periodonticum FPOG_00225 NeuB family; Bacterial transferase hexapeptide; sialic acid O-acetyltransferase (NeuB/D) Neu5Ac synthesis/modification FPOG_00226 CTP transferase 3 and Lipase DGSL2 family (NeuA) CMP-Neu5Ac synthesis FPOG_00227 UDP-N-acetylglucosamine 2-epimerase (NeuC) ManNAc synthesis * F....”
- “...synthesis capabilities. These three organisms also encode putative neuD sialic acid O-acetyltransferases (FNP_1107, FNV1767, and FPOG_00225) that are likely involved in adding O-acetylation to the sialic acid molecules [43] , [44] . This activity appears to be missing from the ssp. nucleatum neu operon. However, its...”
BA5389 bacterial transferase hexapeptide domain protein from Bacillus anthracis str. Ames
29% identity, 42% coverage
A1S_2691 antibiotic acetyltransferase from Acinetobacter baumannii ATCC 17978
48% identity, 19% coverage
EC958_2373 LPS biosynthesis protein from Escherichia coli O25b:H4-ST131
34% identity, 26% coverage
- Comparative Genomic Analysis of Globally Dominant ST131 Clone with Other Epidemiologically Successful Extraintestinal Pathogenic Escherichia coli (ExPEC) Lineages
Shaik, mBio 2017 - “...and ST648, which includes EC958_0460 ( hyxA ), EC958_0461 ( hyxR ), EC958_1112, EC958_1114, EC958_2371, EC958_2373, EC958_4029 ( waaL ), EC958_4030 ( waaU [ waaK ]), EC958_4035 ( waaB [ rfaB ]), EC958_4032 ( waaY [ rfaY ]), EC958_4033 ( waaJ [ rfaJ ]), and EC958_4034...”
- The serum resistome of a globally disseminated multidrug resistant uropathogenic Escherichia coli clone
Phan, PLoS genetics 2013 - “...length 1 X WT WT M EC958_2371 2371 - - 2 LA 0.063 WT R EC958_2373 2373 - - N/A N/A N/A N/A E EC958_2378 rmlC b2038 dTDP-4-deoxyrhamnose-3,5-epimerase 4 LA 0.063 WT M EC958_2379 rmlA b2039 glucose-1-phosphate thymidylyltransferase 2 X WT WT M EC958_2380 rmlD b2040...”
- “...EC958. We were unable to obtain mutants for the remaining 2 genes ( acrA and EC958_2373) despite multiple attempts ( Table 2 ). The 54 defined mutants were subjected to serum susceptibility testing, whereby the number of surviving colonies after a 90-minute exposure to fresh pooled...”
XP_003551487 serine acetyltransferase 1, chloroplastic from Glycine max
32% identity, 25% coverage
mru_1758 acetyltransferase from Methanobrevibacter ruminantium M1
35% identity, 38% coverage
EHI_096770 acetyltransferase, putative from Entamoeba histolytica HM-1:IMSS
32% identity, 45% coverage
- Screening and Structural Characterization of Heat Shock Response Elements (HSEs) in <i>Entamoeba histolytica</i> Promoters
Dorantes-Palma, International journal of molecular sciences 2024 - “...elements, either individually or in combination. Prominent in this group are genes such as acetyltransferase (EHI_096770), Acetyltransferase GNAT family (EHI_137930), and Serine O-acetyltransferase (EHI_021570), all involved in acetyl group transfer, and Vacuolar protein sorting 26A (EHI_162540), which plays a role in protein folding ( Supplementary Table...”
- “...with 21 genes, and Transferase (PC00220) with 39 genes. Within this category, genes like Acetyltransferase (EHI_096770), involved in O-acyltransferase activity, and Methionine Gamma-Lyase (EHI_144610), with functions in binding to heterocyclic or cyclic organic compounds and lyase activity, are found. Similar to the first category, Ehpgp5 is...”
- Global analysis of gene expression in response to L-Cysteine deprivation in the anaerobic protozoan parasite Entamoeba histolytica
Husain, BMC genomics 2011 - “...involved in chitin biosynthetic pathway (Table 1 ). Two other genes encoding putative acetyltransferases (103.m00159, EHI_096770) were also induced 3-5 fold upon L-cysteine deprivation (Table 1 ; Additional file 2 ). These acetyltransferases contain maltose/galactose-O-acetyltransferase domains, and are known to be involved in the acetylation of...”
- “...the pathways that these acetyltransferases are involved in, are not known in E. histolytica . EHI_096770 was also induced upon H 2 O 2 -mediated oxidative (4 fold) or DPTA-NONOate-mediated nitrosative stress (2.7 fold) in E. histolytica [ 23 ]. A gene encoding cyst wall specific...”
LLNZ_10680 bifunctional UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase GlmU from Lactococcus cremoris subsp. cremoris NZ9000
30% identity, 26% coverage
- Genomics and transcriptomics analysis reveals the mechanism of isobutanol tolerance of a laboratory evolved Lactococcus lactis strain
Gupta, Scientific reports 2020 - “...ATP-binding protein 1,904,623 C A Missense_variant LLNZ_09895 Exodeoxyribonuclease V alpha chain 2,058,408 A C Synonymous_variant LLNZ_10680 Bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 2,460,986 C A Missense_variant LLNZ_12940 Predicted ATP-grasp enzyme 2,493,226 A C Upstream_gene_variant LLNZ_13125 ATPase, P-type (transporting), HAD superfamily, subfamily IC Confirmation of the stability of evolved...”
NWMN_0102 capsular polysaccharide synthesis enzyme O-acetyl transferase CapH from Staphylococcus aureus subsp. aureus str. Newman
SA0151 capsular polysaccharide synthesis enzyme O-acetyl transferase Cap5H from Staphylococcus aureus subsp. aureus N315
SAV0156 capsular polysaccharide synthesis enzyme O-acetyl transferase Cap5H from Staphylococcus aureus subsp. aureus Mu50
SAOUHSC_00121 capsular polysaccharide synthesis enzyme O-acetyl transferase Cap5H, putative from Staphylococcus aureus subsp. aureus NCTC 8325
SAUSA300_0159 capsular polysaccharide biosynthesis protein Cap5H from Staphylococcus aureus subsp. aureus USA300_FPR3757
SACOL0143 capsular polysaccharide biosynthesis protein Cap5H from Staphylococcus aureus subsp. aureus COL
Newbould305_0696 CatB-related O-acetyltransferase from Staphylococcus aureus subsp. aureus str. Newbould 305
26% identity, 54% coverage
- The σB-dependent yabJ-spoVG operon is involved in the regulation of extracellular nuclease, lipase, and protease expression in Staphylococcus aureus
Schulthess, Journal of bacteriology 2011 - “...NWMN_0096 NWMN_0097 NWMN_0098 NWMN_0099 NWMN_0100 NWMN_0101 NWMN_0102 NWMN_0103 NWMN_0104 NWMN_0105 NWMN_0106 NWMN_0107 NWMN_0108 NWMN_0152 Gene symbolb 4958...”
- CodY in Staphylococcus aureus: a regulatory link between metabolism and virulence gene expression
Pohl, Journal of bacteriology 2009 - “...NWMN_0097 NWMN_0098 NWMN_0099 NWMN_0100 NWMN_0101 NWMN_0102 NWMN_0103 NWMN_0104 NWMN_0105 NWMN_0107 NWMN_0108 NWMN_0262 NWMN_0525 NWMN_1084 NWMN_1246 NWMN_1872...”
- VraSR and Virulence Trait Modulation during Daptomycin Resistance in Methicillin-Resistant <i>Staphylococcus aureus</i> Infection
Taglialegna, mSphere 2019 - “...capF Capsular polysaccharide biosynthesis protein Cap5F 2.425 SA0150 capG Capsular polysaccharide biosynthesis protein Cap5G 1.798 SA0151 capH Capsular polysaccharide biosynthesis protein Cap5H 3.642 SA0152 capI Capsular polysaccharide biosynthesis protein Cap5I 1.641 SA0153 capJ Capsular polysaccharide biosynthesis protein Cap5J 1.288 SA0154 capK Capsular polysaccharide biosynthesis protein Cap5K...”
- Direct targets of CodY in Staphylococcus aureus
Majerczyk, Journal of bacteriology 2010 - “...SA2022 SA0136 SA0138 SA0139 SA0141 SA0142 SA0148 SA0149 SA0151 SAR2036 SA1168 SA2694 SA1173 SA2003 SA2689 SA2691 SA2462 SA2690 SA1170 SA0248 SA0860 SA1812...”
- Microarray analysis of toxicogenomic effects of ortho-phenylphenol in Staphylococcus aureus
Jang, BMC genomics 2008 - “...sa_c2516s2092_a_at SA0150 5.92E-05 -2.4 UDP-N-acetylglucosamine 2-epimerase (UDP-GlcNAc-2-epimerase) cap G Cell envelope biogenesis, outer membrane sa_c10086s8810_a_at SA0151 0.00025 -2.8 chloramphenicol acetyltransferase (Xenobiotic acetyltransferase) (XAT) cap H General function prediction only sa_c10087s8814_a_at SA0152 0.00017 -2.7 capsular polysaccharide synthesis enzyme Cap5I cap I Cell envelope biogenesis, outer membrane sa_c10089s8822_a_at...”
- Serial daptomycin selection generates daptomycin-nonsusceptible Staphylococcus aureus strains with a heterogeneous vancomycin-intermediate phenotype
Camargo, Antimicrobial agents and chemotherapy 2008 - “...SA0144 SA0145 SA0146 SA0147 SA0148 SA0149 SA0150 SA0151 SA0152 SA0153 SA0154 SA0155 SA0156 SA0157 SA0158 SA0159 Dehydrogenases and oxidoreductases SA0171 SA0204...”
- Characterization of a strain of community-associated methicillin-resistant Staphylococcus aureus widely disseminated in the United States
Tenover, Journal of clinical microbiology 2006 - “...ebh ebh ebh SA0147 SA0148 SA0149 SA0150 SA0151 SA2687 SA2686 SA2685 SA2652 SA1472 SA1472 SA1472 SA1472 SA1472 Capsular polysaccharide Capsular polysaccharide...”
- Overexpression of genes of the cell wall stimulon in clinical isolates of Staphylococcus aureus exhibiting vancomycin-intermediate- S. aureus-type resistance to vancomycin
McAleese, Journal of bacteriology 2006 - “...SA0150 cap5G Capsular polysaccharide synthesis enzyme 2.3 SA0151 cap5H Capsular polysaccharide synthesis enzyme 2.4 SA0205 SA0243 SA0265 SA0620 SA0977 SA0978...”
- Global regulatory impact of ClpP protease of Staphylococcus aureus on regulons involved in virulence, oxidative stress response, autolysis, and DNA repair
Michel, Journal of bacteriology 2006 - “...Other SA0144 SA0145 SA0146 SA0147 SA0148 SA0149 SA0150 SA0151 SA0152 SA0153 SA0154 SA0155 SA0156 SA0157 SA0158 SA0159 SA0252 SA0253 SA0566 SA0841 SA1709 SA2206...”
- Genotypic Characterization of Staphylococcus aureus Obtained from Humans and Bovine Mastitis Samples in India
Prashanth, Journal of global infectious diseases 2011 - “...such as GTP pyrophosokinase, proline dehydrogenase, and a hypothetical protein (coding DNA sequences[CDS] -MW0626 or SAV0156) predicted to be low-affinity inorganic phosphate transporter and a protein that is similar to low temperature requirement B protein (SAV0504 or SA0462). DISCUSSION Infections due to S. aureus are of...”
- Two novel point mutations in clinical Staphylococcus aureus reduce linezolid susceptibility and switch on the stringent response to promote persistent infection
Gao, PLoS pathogens 2010 - “...capD capsular polysaccharide synthesis enzyme Cap5F 80.7 SAV0155 capF capsular polysaccharide synthesis enzyme Cap5G 23.0 SAV0156 capG capsular polysaccharide synthesis enzyme Cap5H 19.0 SAV0157 capI capsular polysaccharide synthesis enzyme Cap5I 39.3 SAV0158 capJ capsular polysaccharide synthesis enzyme Cap5J 14.5 SAV0159 capK capsular polysaccharide synthesis enzyme Cap5K...”
- Low-level predation by lytic phage phiIPLA-RODI promotes biofilm formation and triggers the stringent response in Staphylococcus aureus
Fernández, Scientific reports 2017 - “...FC SAOUHSC_00005 gyrB DNA gyrase subunit B 2.89 SAOUHSC_00006 gyrA DNA gyrase subunit A 3.92 SAOUHSC_00121 Capsular polysaccharide synthesis enzyme O-acetyl transferase Cap5H, putative 2.03 SAOUHSC_00187 pflB Formate acetyltransferase 4.57 SAOUHSC_00188 pflA Pyruvate formate-lyase-activating enzyme 5.52 SAOUHSC_00350 rpsR 30S ribosomal protein S18 2.69 SAOUHSC_00471 glmU Bifunctional...”
- The Staphylococcus aureus KdpDE two-component system couples extracellular K+ sensing and Agr signaling to infection programming
Xue, Infection and immunity 2011 - “...California, Berkeley SAOUHSC_00119 SAOUHSC_00120 SAOUHSC_00121 SAOUHSC_00122 SAOUHSC_00123 SAOUHSC_00124 SAOUHSC_00125 SAOUHSC_00126 SAOUHSC_00127 SAOUHSC_00300...”
- Staphylococcus aureus AI-2 quorum sensing associates with the KdpDE two-component system to regulate capsular polysaccharide synthesis and virulence
Zhao, Infection and immunity 2010 - “...SAOUHSC_00399 SAOUHSC_00433 SAOUHSC_00384 SAOUHSC_00389 SAOUHSC_00121 SAOUHSC_00122 SAOUHSC_00123 SAOUHSC_00124 SAOUHSC_00119 SAOUHSC_00120 SAOUHSC_00125...”
- Identification of novel genetic factors that regulate c-di-AMP production in <i>Staphylococcus aureus</i> using a riboswitch-based biosensor
Kviatkovski, mSphere 2024 - “...SAUSA300_0153 (capB), SAUSA300_0154 ( capC ) , SAUSA300_0155 (capD), SAUSA300_0156 (capE), SAUSA300_0157 (capF), SAUSA300_0158 (capG), SAUSA300_0159 (capH), SAUSA300_0160 (capI), SAUSA300_0161 (capJ), SAUSA300_0162 (capK), SAUSA300_0163 (capL), SAUSA300_0164 (capM), SAUSA300_0165 (capN), SAUSA300_0166 (capO), SAUSA300_0167 (capP ) 1S2E5 Between SAUSA300_2037 and SAUSA300_2038 SAUSA300_2037: cshA (ATP-dependent RNA helicase) SAUSA300_2038: murF...”
- The Staphylococcus aureus α-Acetolactate Synthase ALS Confers Resistance to Nitrosative Stress
Carvalho, Frontiers in microbiology 2017 - “...good anti-correlation are colored red and uncorrelated genes are colored gray. SAUSA300_0152 ( cap5A ), SAUSA300_0159 ( cap5H ), SAUSA300_2597 ( cap1B ), SAUSA300_2598 ( cap1A ), SAUSA300_0220 ( pflB ), SAUSA300_0226-28 ( fadBDE ), SAUSA300_0235 ( lctE ), SAUSA300_0885-6 ( fabHF ), SAUSA300_1123-4 ( fadDG...”
- Antimicrobial effect and mode of action of terpeneless cold-pressed Valencia orange essential oil on methicillin-resistant Staphylococcus aureus
Muthaiyan, Journal of applied microbiology 2012 - “...2.17 SACOL2092 murAA UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1 Biosynthesis and degradation of murein sacculus and peptidoglycan 2.1 SACOL0143 cap5H capsular polysaccharide biosynthesis protein Cap5H Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides 2.04 SACOL0699 pbp4 penicillin-binding protein 4 Biosynthesis and degradation of murein sacculus and peptidoglycan 2.04 SACOL0142...”
- A proteomic view of an important human pathogen--towards the quantification of the entire Staphylococcus aureus proteome
Becher, PloS one 2009 - “...SACOL0994 (OppF), SACOL0995, SACOL1963, SACOL2450, SACOL0991 (OppB)], CPS (capsular polysaccharide) biosynthesis [SACOL0151 (Cap5P), SACOL0138 (Cap5C), SACOL0143 (Cap5H), SACOL0137 (Cap5B), SACOL0136 (Cap5A), SACOL0142 (Cap5G), SACOL0150 (Cap5O), SACOL0145 (Cap5J), glycerol utilization [SACOL0805, SACOL1514 (GpsA), SACOL2415 (Gpm), SACOL1320 (GlpK), SACOL1319 (GlpF), SACOL0200, SACOL0407 (GlpT)], or consumption of alternative sugars...”
- Staphylococcus aureus HrtA is an ATPase required for protection against heme toxicity and prevention of a transcriptional heme stress response
Stauff, Journal of bacteriology 2008 - “...23.7 SACOL0137 11.5 cap5B SACOL0138 11.2 cap5C SACOL0143 8.3 cap5H SACOL1637 SACOL1865 SACOL1866 SACOL1867 SACOL1872 SACOL1873 SACOL2007 SACOL2419 SACOL2421...”
- Comparative genomics of Canadian epidemic lineages of methicillin-resistant Staphylococcus aureus
Christianson, Journal of clinical microbiology 2007 - “...CGTC GAAACGAAGCAGATGAACGC CGTA CATCTGCAAGGGATCGTTCTTTGA SA0046R SACOL0143 cap5H SACOL0144 cap5I SA0143F SA0143R SA0144F SA0144R SACOL0145 cap5J SA0145F...”
- “...agrB SACOL2506 sarT SACOL2507 sarU Other SACOL0046 SACOL0143 cap5H SACOL0144 cap5I SACOL0145 cap5J SACOL2196 a Metallo-beta-lactamase family protein Capsular...”
- Recombination-mediated remodelling of host-pathogen interactions during Staphylococcus aureus niche adaptation
Spoor, Microbial genomics 2015 - “...) MW0064 LysR family transcriptional regulator SARLGA251_24290 Putative lipoprotein Genes lost in ST71 strains cap5H Newbould305_0696 Capsular polysaccharide synthesis protein O -acetyltransferase Cap5H cap5I Newbould305_0697 Capsular polysaccharide biosynthesis protein Cap5I cap5J Newbould305_0698 Capsular polysaccharide synthesis protein Cap5J cap5K Newbould305_0699 Capsular polysaccharide biosynthesis protein Cap5K hsdM Newbould305_0618...”
CPE1321 serine O-acetyltransferase from Clostridium perfringens str. 13
34% identity, 37% coverage
BF4020 putative maltose O-acetyltransferase from Bacteroides fragilis YCH46
BF9343_3693, I6J55_RS16055 sugar O-acetyltransferase from Bacteroides fragilis
29% identity, 38% coverage
- A family of transcriptional antitermination factors necessary for synthesis of the capsular polysaccharides of Bacteroides fragilis
Chatzidaki-Livanis, Journal of bacteriology 2009 - “...B. fragilis genome encodes a bona fide NusG ortholog (BF4020) whose gene is contained in a conserved Species of the genus Bacteroides are collectively the most...”
- Multi-omics approach for understanding the response of Bacteroides fragilis to carbapenems
Zholdybayeva, Heliyon 2024 - “...(estS) 9,76E-01 transferase activity BF9343_3520 4-alpha-glucanotransferase (malQ) 1,42E+00 BF9343_0575 Putative transmembrane acyl-transferase protein (BF9343_0575) 1,20E+00 BF9343_3693 sugar O-acetyltransferase (I6J55_RS16055) 1,46E+00 helicase activity BF9343_3290 ATP-dependent DNA helicase (BF9343_3290) 6,93E-01 zinc ion binding BF9343_0605 nucleoside deaminase (I6J55_RS10685) 4,99E+00 mechanically-gated ion channel activity BF9343_2995 mechanosensitive ion channel (I6J55_RS19740) 7,94E-01...”
- “...activity BF9343_3520 4-alpha-glucanotransferase (malQ) 1,42E+00 BF9343_0575 Putative transmembrane acyl-transferase protein (BF9343_0575) 1,20E+00 BF9343_3693 sugar O-acetyltransferase (I6J55_RS16055) 1,46E+00 helicase activity BF9343_3290 ATP-dependent DNA helicase (BF9343_3290) 6,93E-01 zinc ion binding BF9343_0605 nucleoside deaminase (I6J55_RS10685) 4,99E+00 mechanically-gated ion channel activity BF9343_2995 mechanosensitive ion channel (I6J55_RS19740) 7,94E-01 antiporter activity BF9343_3501...”
Q9L9Q2 N-acetylneuraminate 7-O(or 9-O)-acetyltransferase (EC 2.3.1.45) from Campylobacter jejuni (see paper)
33% identity, 29% coverage
MGAS2096_Spy1118 Virginiamycin A acetyltransferase from Streptococcus pyogenes MGAS2096
47% identity, 22% coverage
SAT52 / Q42538 serine acetyltransferase (EC 2.3.1.30) from Arabidopsis thaliana (see 4 papers)
SAT5_ARATH / Q42538 Serine acetyltransferase 5; AtSAT-5; AtSERAT1;1; SAT-c; EC 2.3.1.30 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
Q42538 serine O-acetyltransferase (EC 2.3.1.30) from Arabidopsis thaliana (see 4 papers)
NP_200487 serine acetyltransferase 1;1 from Arabidopsis thaliana
AT5G56760 ATSERAT1;1 (ARABIDOPSIS THALIANA SERINE ACETYLTRANSFERASE 1;1); serine O-acetyltransferase from Arabidopsis thaliana
35% identity, 32% coverage
- catalytic activity: L-serine + acetyl-CoA = O-acetyl-L-serine + CoA (RHEA:24560)
subunit: Homomultimer. - Photorespiration: regulation and new insights on the potential role of persulfidation
Aroca, Journal of experimental botany 2023 - “...P (3) AT3G13110 Q39218 SAT3 Serine acetyltransferase 3, mitochondrial P (3) , S (5,7) AT5G56760 Q42538 SAT5 Serine acetyltransferase 5 P (3) AT5G04590 Q9LZ66 SIR Assimilatory sulfite reductase (ferredoxin) chloroplastic P (3,4) , S (6,7) AT1G79230 O64530 STR1 Thiosulfate/3-mercaptopyruvate sulfurtransferase 1 mitochondrial P (3,4) , S...”
- Analysis of cytosolic and plastidic serine acetyltransferase mutants and subcellular metabolite distributions suggests interplay of the cellular compartments for cysteine biosynthesis in Arabidopsis.
Krueger, Plant, cell & environment 2009 (PubMed)- GeneRIF: Cytosolic SERAT1.1 and plastidic SERAT2.1 do not contribute to cysteine biosynthesis.
- Comparative genomics and reverse genetics analysis reveal indispensable functions of the serine acetyltransferase gene family in Arabidopsis.
Watanabe, The Plant cell 2008 - GeneRIF: SERAT1;1 may play a major role during seed development.
- In silico assessment of gene function involved in cysteine biosynthesis in Arabidopsis: expression analysis of multiple isoforms of serine acetyltransferase.
Noji, Amino acids 2006 (PubMed)- GeneRIF: From the results of sensitivity to feedback regulation, subcellular localization and expression of mRNA analyses, each serine acetyltransferase (SATase) isoform seems to have its specific role for cysteine biosynthesis.
- New insights into the regulation of plant metabolism by O-acetylserine: sulfate and beyond
Apodiakou, Journal of experimental botany 2023 - “...SERAT2;1 (AT1G55920) and SERAT2;2 (AT3G13110), which are localized in plastids and mitochondria, respectively, and SERAT1;1 (AT5G56760), SERAT3;1 (AT2G17640), and SERAT3;2 (AT4G35640), which are localized and expressed in the cytosol ( Watanabe et al. , 2008 ; Krueger et al. , 2009 ). When plants experience reduced...”
- “...co-expression network ( Fig. 2 ; Table 1 ). Of the five SERAT genes, SERAT1;1 (At5g56760), SERAT2;1 (At1g55920), SERAT2;2 (At3g13110), SERAT3;1 (At2g17640), and SERAT3;2 (At4g35640), each has a different transcriptional response to certain conditions ( Watanabe and Hoefgen, 2017 ). It was shown that SERAT group...”
- Photorespiration: regulation and new insights on the potential role of persulfidation
Aroca, Journal of experimental botany 2023 - “...2 P (3) AT3G13110 Q39218 SAT3 Serine acetyltransferase 3, mitochondrial P (3) , S (5,7) AT5G56760 Q42538 SAT5 Serine acetyltransferase 5 P (3) AT5G04590 Q9LZ66 SIR Assimilatory sulfite reductase (ferredoxin) chloroplastic P (3,4) , S (6,7) AT1G79230 O64530 STR1 Thiosulfate/3-mercaptopyruvate sulfurtransferase 1 mitochondrial P (3,4) ,...”
- A molecular switch in sulfur metabolism to reduce arsenic and enrich selenium in rice grain
Sun, Nature communications 2021 - “...were used as the primary antibodies. Microscale thermophoresis analysis Ten C-terminal residues 38 of AtSAT5 (AT5G56760, sequence: FISEWSDYII), required for binding with OAS-TL, was synthesized by GenScript Biotech (Nanjing). Recombinant His-tagged OAS-TL proteins were labeled with RED-tris-NTA 2 nd Generation Dye for 30min. For the binding...”
- Chemical Priming by Isothiocyanates Protects Against Intoxication by Products of the Mustard Oil Bomb
Ferber, Frontiers in plant science 2020 - “...AT5G27380) and all five cysteine forming enzymes of the serine acetyltransferase (SAT) gene family: SERAT1;1 (At5g56760, SAT-c), SERAT2;1 (At1g55920, SAT-p), SERAT2;2 (At3g13110, SAT-m), SERAT3;1 (At2g17640, SAT-106) and SERAT3;2 (At4g35640). Except for SERAT2;1 which was found to be induced by 1.6-fold by SF 4 h after treatment,...”
- Tandem Fluorescent Protein Timers for Noninvasive Relative Protein Lifetime Measurement in Plants
Zhang, Plant physiology 2019 - “...fascinating and extensive plasticity of the plant proteome. MATERIALS AND METHODS SAT5 Construct Full-length SAT5 (AT5G56760) was amplified from Arabidopsis ( Arabidopsis thaliana ) leaf cDNA using the SAT5-tFT_For and SAT5-tFT_Rev primers by PCR and fused with the tFT tag that was PCR amplified from pMaM17...”
- “...data from this article can be found in the GenBank data library under accession numbers At5g56760 (SAT5), At3g24800 (PRT1), At5g02310 (PRT6), At1g04250 (IAA17), At5g25890 (IAA28), At3g17600 (IAA31), At3g62980 (TIR1), and At3g26810 (AFB2). Supplemental Data The following supplemental materials are available. Supplemental Figure S1. Nuclear-cytosolic localization of...”
- The Effect of Single and Multiple SERAT Mutants on Serine and Sulfur Metabolism
Watanabe, Frontiers in plant science 2018 - “...in each subcellular compartment. Table 1 SERAT gene family. Gene name AGI code Localization SERAT1;1 At5g56760 Cytosol SERAT2;1 At1g55920 Plastids SERAT2;2 At3g13110 Mitochondria SERAT3;1 At2g17640 Cytosol SERAT3;2 At4g45640 Cytosol Despite of the fact that OAS and cysteine are synthesized in multiple subcellular compartments, Arabidopsis knockout mutants...”
- Characterization of the serine acetyltransferase gene family of Vitis vinifera uncovers differences in regulation of OAS synthesis in woody plants
Tavares, Frontiers in plant science 2015 - “...cysteine synthesis and contributes in leaves approximately 80% of total SERAT activity, while cytosolic AtSERAT1;1 (At5g56760) and plastidic AtSERAT2;1 (At1g55920) amount to 15 and 5% of the remaining total SERAT activity, respectively (Haas et al., 2008 ; Watanabe et al., 2008 ). The insignificant contribution to...”
- Affinity Purification of O-Acetylserine(thiol)lyase from Chlorella sorokiniana by Recombinant Proteins from Arabidopsis thaliana
Salbitani, Metabolites 2014 - “...S-starved cultures were used for the purification of OASTL proteins by interaction with recombinant AtSAT5 (At5g56760). The crude extract preparation was already described in the previous paragraph (3.2). AtSAT5 protein from Arabidopsis thaliana was over-expressed in Escherichia coli HMS174 (DE3) and immobilized on a nickel-loaded Hi-trap...”
- More
PA3753 hypothetical protein from Pseudomonas aeruginosa PAO1
32% identity, 54% coverage
AK34_3721 gamma carbonic anhydrase family protein from Burkholderia dolosa AU0158
35% identity, 44% coverage
Q5GTJ4 Bifunctional protein GlmU from Wolbachia sp. subsp. Brugia malayi (strain TRS)
34% identity, 31% coverage
LOC107808059 serine acetyltransferase 1, chloroplastic-like from Nicotiana tabacum
34% identity, 28% coverage
- Alternative Oxidase Inhibition Impairs Tobacco Root Development and Root Hair Formation
Liu, Frontiers in plant science 2021 - “...noted that several DEGs (|log 2 FC 1|) were commonly enriched in these pathways, i.e., LOC107808059 and LOC107804363, which encode serine acetyltransferase, were enriched in the KEGG pathways of Carbon metabolism, Biosynthesis of amino acids, and Cysteine and methionine metabolism, and showed upregulation on SHAM treatment...”
SAG0913 chloramphenicol acetyltransferase from Streptococcus agalactiae 2603V/R
37% identity, 25% coverage
WP_172158671 CatB-related O-acetyltransferase from Komagataeibacter melomenusus
43% identity, 23% coverage
Nmag_3011 hexapaptide repeat-containing transferase from Natrialba magadii ATCC 43099
32% identity, 47% coverage
- A comparative genomics perspective on the genetic content of the alkaliphilic haloarchaeon Natrialba magadii ATCC 43099T
Siddaramappa, BMC genomics 2012 - “...3512, 3832, and 3843) superfamilies. One of these genes (Nmag_3015) is in an operon with Nmag_3011 (hexapeptide repeat-containing transferase, 192 aa), Nmag_3012 (aminotransferase, 481 aa), Nmag_3013 (oxidoreductase, 340 aa), and Nmag_3014 (nucleotide sugar dehydrogenase, 544 aa). Nab . magadii also contained genes encoding a putative oligosaccharyltransferase...”
CHF17_RS05275 CatB-related O-acetyltransferase from Streptococcus agalactiae
37% identity, 25% coverage
LIC12184 acetyl transferase from Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130
26% identity, 64% coverage
WP_000759956 acyltransferase from Escherichia coli
33% identity, 50% coverage
4n69A / I1KHY6 Soybean serine acetyltransferase complexed with serine (see paper)
35% identity, 39% coverage
OKIT_0692 sugar O-acetyltransferase from Oenococcus kitaharae DSM 17330
33% identity, 31% coverage
CU052_26580 CatB-related O-acetyltransferase from Vibrio harveyi
29% identity, 54% coverage
YP_003433556 UDP-N-acetylglucosamine pyrophosphorylase from Hydrogenobacter thermophilus TK-6
32% identity, 24% coverage
- Phylogenetic position of aquificales based on the whole genome sequences of six aquificales species
Oshima, International journal of evolutionary biology 2012 - “...YP_003432239 ribosomal protein S9 YP_003432379 ribosomal protein L18 YP_003432892 4-hydroxy-3-methylbut-2-enyl diphosphate reductase YP_003432936 ATP-dependent protease YP_003433556 UDP-N-acetylglucosamine pyrophosphorylase YP_003431738 putative metalloprotease YP_003431749 diaminopimelate decarboxylase YP_003431809 dihydrodipicolinate reductase YP_003431998 UDP-N-acetylglucosamine 1-carboxyvinyltransferase YP_003432481 ribosomal protein S20 YP_003432953 queuine tRNA-ribosyltransferase YP_003431834 ATP-dependent protease La YP_003431839 tRNA delta(2)-isopentenylpyrophosphate transferase YP_003431873...”
D6R50_13775 CatB-related O-acetyltransferase from Aeromonas veronii
31% identity, 51% coverage
ETAE_1960 serine acetyltransferase-related protein from Edwardsiella tarda EIB202
36% identity, 37% coverage
SpyM3_1674 putative serine acetyltransferase from Streptococcus pyogenes MGAS315
36% identity, 39% coverage
- Novel regulatory small RNAs in Streptococcus pyogenes
Tesorero, PloS one 2013 - “...SPyM3_1645 putative response regulator of salavaricin regulon <<< Q, Z SSRC37 SPyM3_1673 hypothetical protein <<< SPyM3_1674 putative serine acetyltransferase <<< Q, Z SSRC38 SPyM3_1725 laminin-binding protein <<< SPyM3_1726 C5A peptidase precursor <<< Q, Z SSRC39 SPyM3_1726 C5A peptidase precursor <<< SPyM3_1727 antiphagocytic M protein, type 3...”
ETAE_3456 serine acetyltransferase from Edwardsiella tarda EIB202
33% identity, 38% coverage
NP_624622 acetyltransferase from Streptomyces coelicolor A3(2)
49% identity, 20% coverage
- Rickettsia phylogenomics: unwinding the intricacies of obligate intracellular life
Gillespie, PloS one 2008 - “...SI85-9A1; acetyltransferase 57.8 2.00E-07 YP_001182985 Shewanella putrefaciens CN-32; transferase hexapeptide repeat containing protein 57.8 2.00E-07 NP_624622 Streptomyces coelicolor A3(2); acetyltransferase 57.8 2.00E-07 YP_001038094 Clostridium thermocellum ATCC 27405; HP Cthe_1678 57.4 2.00E-07 YP_870325 Shewanella sp. ANA-3; streptogramin A acetyl transferase 57.4 2.00E-07 YP_001049952 Shewanella baltica OS155; transferase...”
CJJ81176_1162 acetyltransferase from Campylobacter jejuni subsp. jejuni 81-176
40% identity, 23% coverage
perB / Q7DBF7 GDP-perosamine N-acetyltransferase monomer (EC 2.3.1.227) from Escherichia coli O157:H7 (see 2 papers)
PERB_ECO57 / Q7DBF7 GDP-perosamine N-acetyltransferase; EC 2.3.1.227 from Escherichia coli O157:H7 (see paper)
Z3192 acetyl transferase; O-antigen biosynthesis from Escherichia coli O157:H7 EDL933
ECs2831 acetyltransferase from Escherichia coli O157:H7 str. Sakai
28% identity, 48% coverage
FTN_1428 transferase from Francisella tularensis subsp. novicida U112
29% identity, 49% coverage
- The Francisella tularensis Polysaccharides: What Is the Real Capsule?
Freudenberger, Microbiology and molecular biology reviews : MMBR 2020 (secret) - Common ancestry and novel genetic traits of Francisella novicida-like isolates from North America and Australia as revealed by comparative genomic analyses
Siddaramappa, Applied and environmental microbiology 2011 - “...ORFs that were strain specific (FTN_1422, FTN_1424, and FTN_1428). The wbt gene clusters of F. novicida-like strains 3523 and Fx1 contained four contiguous...”
- Francisella-arthropod vector interaction and its role in patho-adaptation to infect mammals
Akimana, Frontiers in microbiology 2011 - “...superfamily (MFS) transport protein, pseudogene FTN_1412 DNA-directed RNA polymerase e subunit x FTN_1417 Phosphomannomutase manB FTN_1428 Transferase wbtO FTN_1439 3-Ketoacyl-CoA thiolase fadA FTN_1441 Sugar transport protein, pseudogene FTN_1448 Protein of unknown function FTN_1452 Two-component response regulator FTN_1457 Protein of unknown function FTN_1465 Two-component response regulator pmrA...”
- Molecular complexity orchestrates modulation of phagosome biogenesis and escape to the cytosol of macrophages by Francisella tularensis
Asare, Environmental microbiology 2010 - “...2 5 5 # tnfn1_pw060328p01q142 FTN_0928 cysD sulfate adenylyltransferase subunit 2 3 3 # tnfn1_pw060323p03q182 FTN_1428 wbtO transferase 3 2 # tnfn1_pw060510p01q119 FTN_1428 wbtO transferase 2 6 # DNA modifying tnfn1_pw060323p03q125 FTN_0133 ribonuclease II family protein 2 2 tnfn1_pw060510p02q141 FTN_0133 ribonuclease II family protein 5 5...”
- “...FTN_0988 prmA 78 Phagosomal tnfn1_pw060510p02q144 FTN_1234 queA 67 Phagosomal tnfn1_pw060418p04q172 FTN_1418 manC 68 Phagosomal tnfn1_pw060510p01q119 FTN_1428 wbtO 82 Phagosomal Transcription/Translation tnfn1_pw060510p03q168 FTN_0598 42 Cytoplasmic tnfn1_pw060419p04q129 FTN_1290 mglA 71 Phagosomal Type IV Pilin tnfn1_pw060418p02q167 FTN_1137 pilQ 66 Phagosomal tnfn1_pw060323p06q157 FTN_1139 pilO 67 Phagosomal Others tnfn1_pw060323p08q110 FTN_0286 73...”
- Exploitation of host cell biology and evasion of immunity by francisella tularensis
Asare, Frontiers in microbiology 2010 - “...ribosyltransferase-isomerase FTN_1333 tktA Transketolase I FTN_1415 Thioredoxin FTN_1417 manB Phosphomannomutase FTN_1421 wbtH Glutamine amidotransferase/asparagine synthase FTN_1428 wbtO Transferase FTN_1494 aceE Pyruvate dehydrogenase complex, E1 component, pyruvate dehydrogenase FTN_1523 Amino acidpolyamineorganocation family protein FTN_1553 nudH dGTP pyrophosphohydrolase FTN_1557 Oxidoreductase iron/ascorbate family protein FTN_1584 glpD Glycerol-3-phosphate dehydrogenase FTN_1585...”
- “...Lactoylglutathione lyase FTN_1234 queA S-adenosylmethionine: tRNA ribosyltransferase- isomerase FTN_1333 tktA Transketolase I FTN_1376 FTN_1418 manC FTN_1428 wbtO Transferase FTN_1494 aceE Pyruvate dehydrogenase complex, E1 component, pyruvate dehydrogenase FTN_1553 nudH dGTP pyrophosphohydrolase FTN_1597 prfC Peptide chain release factor 3 FTN_1621 Predicted NAD/FAD-dependent oxidoreductase FTN_1655 rluC Ribosomal large...”
- Molecular bases of proliferation of Francisella tularensis in arthropod vectors
Asare, Environmental microbiology 2010 - “...2 5 5 # tnfn1_pw060328p01q142 FTN_0928 cysD sulfate adenylyltransferase subunit 2 3 3 # tnfn1_pw060323p03q182 FTN_1428 wbtO transferase 3 2 # tnfn1_pw060510p01q119 FTN_1428 wbtO transferase 2 6 # DNA modifying tnfn1_pw060323p03q125 FTN_0133 ribonuclease II family protein 2 2 tnfn1_pw060510p02q141 FTN_0133 ribonuclease II family protein 5 5...”
- “...4 87% 2.7E-03 tnfn1_pw060328p01q142 FTN_0928 cysD sulfate adenylyltransferase subunit 2 3 3 57% 9.6E-02 tnfn1_pw060510p01q119 FTN_1428 wbtO transferase 6 2 50% 4.1E-01 tnfn1_pw060420p02q146 FTN_0300 glycosyl transferase, group 2 5 30% 6.8E-02 tnfn1_pw060323p03q121 FTN_0343 aminotransferase 2 7 20% 1.9E+01 tnfn1_pw060418p01q110 FTN_0200 UDP-3-O-[3-fatty acid] glucosamine N-acyltransferase 2 2...”
SA0717 hypothetical protein from Staphylococcus aureus subsp. aureus N315
34% identity, 37% coverage
GSU2572 serine acetyltransferase from Geobacter sulfurreducens PCA
34% identity, 46% coverage
Q04KU2 Bifunctional protein GlmU from Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)
SPD_0874 UDP-N-acetylglucosamine pyrophosphorylase from Streptococcus pneumoniae D39
34% identity, 26% coverage
- Dysregulation of Streptococcus pneumoniae zinc homeostasis breaks ampicillin resistance in a pneumonia infection model
Brazel, Cell reports 2022 - “...GlmM and GlmU expression and purification DNA sequences encoding GlmM (UniProtK Q04J18) and GlmU (UniProt Q04KU2) ordered from GenScript (Hong Kong) Ltd. in plasmid pUC57, were amplified via PCR and subcloned into pGEX-6P-1. The GlmU E315AH330A variant was generated using a Q5 Site-Directed Mutagenesis kit (New...”
- Identification of novel acetyltransferase activity on the thermostable protein ST0452 from Sulfolobus tokodaii strain 7
Zhang, Journal of bacteriology 2010 - “...and Streptococcus pneumoniae (Uniprot accession number Q04KU2), the MJ1101 protein from Methanocaldococcus janaschii (Uniprot accession number Q58501), the...”
- Dysregulation of Streptococcus pneumoniae zinc homeostasis breaks ampicillin resistance in a pneumonia infection model
Brazel, Cell reports 2022 - “...served as the reference genome to determine the presence, amino acid sequence and alignment of spd_0874 ( glmU ) across the 20,010 clinical isolates using the screen_assembly script ( Davies et al., 2019 ) and BLASTN v2.9.0 with parameters of 80% coverage and 80% identity. Amino...”
- Cadmium stress dictates central carbon flux and alters membrane composition in Streptococcus pneumoniae
Neville, Communications biology 2020 - “...SPD_1463 PsaA MTSA_STRPN Mn 2+ ABC transporter substrate-binding protein Mn 2+ 27 8 25 47,49,51 SPD_0874 GlmU GLMU_STRP4 UDP-N-acetylglucosamine pyrophosphorylase Mg 2+ 100 87 46 49,51,53,55 SPD_1012 Eno ENO_STRPI Enolase (EC 4.2.1.11) Mg 2+ 152 28 32 55,57,59 SPD_0389 AccD ACCD_STRPN Acetyl-CoA carboxylase subunit D (EC...”
- The LuxS/AI-2 Quorum-Sensing System of Streptococcus pneumoniae Is Required to Cause Disease, and to Regulate Virulence- and Metabolism-Related Genes in a Rat Model of Middle Ear Infection
Yadav, Frontiers in cellular and infection microbiology 2018 - “...via tagatose-6-phosphate 138.73 63 SPD_0777 ( thiI ) Probable tRNAsulfurtransferase Thiamine biosynthetic process 2.60 64 SPD_0874 ( glmU ) Bifunctional protein GlmU Cell wall organization 84.33 65 SPD_0877 ( mtnN ) 5-methylthioadenosine/S-adenosylhomocysteine nucleosidase Methylthioadenosine nucleosidase activity 171.33 66 SPD_1133 ( pyrB ) Aspartate carbamoyltransferase de novo...”
- High-throughput CRISPRi phenotyping identifies new essential genes in Streptococcus pneumoniae
Liu, Molecular systems biology 2017 - “...) rpoD ( SPD_0958 ) rodA ( SPD_0706 ) rpoC ( SPD_1758 ) glmU ( SPD_0874 ) rpoB ( SPD_1759 ) ftsW ( SPD_0952 ) Translation Condensed nucleoids; short cells; heterogeneous cell size rpsJ ( SPD_0192 ) murE ( SPD_1359 ) rplD ( SPD_0194 ) murF...”
sat / CAD67560.1 serine O-acetyltransferase from Beta vulgaris (see paper)
34% identity, 34% coverage
LLKF_1624 acetyltransferase from Lactococcus lactis subsp. lactis KF147
30% identity, 37% coverage
Alvin_0863 serine O-acetyltransferase from Allochromatium vinosum DSM 180
31% identity, 45% coverage
- Metabolomic profiling of the purple sulfur bacterium Allochromatium vinosum during growth on different reduced sulfur compounds and malate
Weissgerber, Metabolomics : Official journal of the Metabolomic Society 2014 - “...does not involve formation of phosphoadenosine-5-phosphosulfate (Neumann et al. 2000 ). CysE serine O -acetyltransferase (Alvin_0863), CysM cysteine synthase B (Alvin_2228), GshA glutamate/cysteine ligase (Alvin_800), GshB glutathione synthetase (Alvin_0197), -GluCys -glutamylcysteine, GSH glutathione, XSH glutathione, reduced thioredoxin or glutaredoxin, XSSX oxidized glutathione, thioredoxin or glutaredoxin (see...”
For advice on how to use these tools together, see
Interactive tools for functional annotation of bacterial genomes.
The PaperBLAST database links 789,361 different protein sequences to 1,256,019 scientific articles. Searches against EuropePMC were last performed on January 10 2025.
PaperBLAST builds a database of protein sequences that are linked
to scientific articles. These links come from automated text searches
against the articles in EuropePMC
and from manually-curated information from GeneRIF, UniProtKB/Swiss-Prot,
BRENDA,
CAZy (as made available by dbCAN),
BioLiP,
CharProtDB,
MetaCyc,
EcoCyc,
TCDB,
REBASE,
the Fitness Browser,
and a subset of the European Nucleotide Archive with the /experiment tag.
Given this database and a protein sequence query,
PaperBLAST uses protein-protein BLAST
to find similar sequences with E < 0.001.
To build the database, we query EuropePMC with locus tags, with RefSeq protein
identifiers, and with UniProt
accessions. We obtain the locus tags from RefSeq or from MicrobesOnline. We use
queries of the form "locus_tag AND genus_name" to try to ensure that
the paper is actually discussing that gene. Because EuropePMC indexes
most recent biomedical papers, even if they are not open access, some
of the links may be to papers that you cannot read or that our
computers cannot read. We query each of these identifiers that
appears in the open access part of EuropePMC, as well as every locus
tag that appears in the 500 most-referenced genomes, so that a gene
may appear in the PaperBLAST results even though none of the papers
that mention it are open access. We also incorporate text-mined links
from EuropePMC that link open access articles to UniProt or RefSeq
identifiers. (This yields some additional links because EuropePMC
uses different heuristics for their text mining than we do.)
For every article that mentions a locus tag, a RefSeq protein
identifier, or a UniProt accession, we try to select one or two
snippets of text that refer to the protein. If we cannot get access to
the full text, we try to select a snippet from the abstract, but
unfortunately, unique identifiers such as locus tags are rarely
provided in abstracts.
PaperBLAST also incorporates manually-curated protein functions:
- Proteins from NCBI's RefSeq are included if a
GeneRIF
entry links the gene to an article in
PubMed®.
GeneRIF also provides a short summary of the article's claim about the
protein, which is shown instead of a snippet.
- Proteins from Swiss-Prot (the curated part of UniProt)
are included if the curators
identified experimental evidence for the protein's function (evidence
code ECO:0000269). For these proteins, the fields of the Swiss-Prot entry that
describe the protein's function are shown (with bold headings).
- Proteins from BRENDA,
a curated database of enzymes, are included if they are linked to a paper in PubMed
and their full sequence is known.
- Every protein from the non-redundant subset of
BioLiP,
a database
of ligand-binding sites and catalytic residues in protein structures, is included. Since BioLiP itself
does not include descriptions of the proteins, those are taken from the
Protein Data Bank.
Descriptions from PDB rely on the original submitter of the
structure and cannot be updated by others, so they may be less reliable.
(For SitesBLAST and Sites on a Tree, we use a larger subset of BioLiP so that every
ligand is represented among a group of structures with similar sequences, but for
PaperBLAST, we use the non-redundant set provided by BioLiP.)
- Every protein from EcoCyc, a curated
database of the proteins in Escherichia coli K-12, is included, regardless
of whether they are characterized or not.
- Proteins from the MetaCyc metabolic pathway database
are included if they are linked to a paper in PubMed and their full sequence is known.
- Proteins from the Transport Classification Database (TCDB)
are included if they have known substrate(s), have reference(s),
and are not described as uncharacterized or putative.
(Some of the references are not visible on the PaperBLAST web site.)
- Every protein from CharProtDB,
a database of experimentally characterized protein annotations, is included.
- Proteins from the CAZy database of carbohydrate-active enzymes
are included if they are associated with an Enzyme Classification number.
Even though CAZy does not provide links from individual protein sequences to papers,
these should all be experimentally-characterized proteins.
- Proteins from the REBASE database
of restriction enzymes are included if they have known specificity.
- Every protein with an evidence-based reannotation (based on mutant phenotypes)
in the Fitness Browser is included.
- Sequence-specific transcription factors (including sigma factors and DNA-binding response regulators)
with experimentally-determined DNA binding sites from the
PRODORIC database of gene regulation in prokaryotes.
- Putative transcription factors from RegPrecise
that have manually-curated predictions for their binding sites. These predictions are based on
conserved putative regulatory sites across genomes that contain similar transcription factors,
so PaperBLAST clusters the TFs at 70% identity and retains just one member of each cluster.
- Coding sequence (CDS) features from the
European Nucleotide Archive (ENA)
are included if the /experiment tag is set (implying that there is experimental evidence for the annotation),
the nucleotide entry links to paper(s) in PubMed,
and the nucleotide entry is from the STD data class
(implying that these are targeted annotated sequences, not from shotgun sequencing).
Also, to filter out genes whose transcription or translation was detected, but whose function
was not studied, nucleotide entries or papers with more than 25 such proteins are excluded.
Descriptions from ENA rely on the original submitter of the
sequence and cannot be updated by others, so they may be less reliable.
Except for GeneRIF and ENA,
the curated entries include a short curated
description of the protein's function.
For entries from BioLiP, the protein's function may not be known beyond binding to the ligand.
Many of these entries also link to articles in PubMed.
For more information see the
PaperBLAST paper (mSystems 2017)
or the code.
You can download PaperBLAST's database here.
Changes to PaperBLAST since the paper was written:
- November 2023: incorporated PRODORIC and RegPrecise. Many PRODORIC entries were not linked to a protein sequence (no UniProt identifier), so we added this information.
- February 2023: BioLiP changed their download format. PaperBLAST now includes their non-redundant subset. SitesBLAST and Sites on a Tree use a larger non-redundant subset that ensures that every ligand is represented within each cluster. This should ensure that every binding site is represented.
- June 2022: incorporated some coding sequences from ENA with the /experiment tag.
- March 2022: incorporated BioLiP.
- April 2020: incorporated TCDB.
- April 2019: EuropePMC now returns table entries in their search results. This has expanded PaperBLAST's database, but most of the new entries are of low relevance, and the resulting snippets are often just lists of locus tags with annotations.
- February 2018: the alignment page reports the conservation of the hit's functional sites (if available from from Swiss-Prot or UniProt)
- January 2018: incorporated BRENDA.
- December 2017: incorporated MetaCyc, CharProtDB, CAZy, REBASE, and the reannotations from the Fitness Browser.
- September 2017: EuropePMC no longer returns some table entries in their search results. This has shrunk PaperBLAST's database, but has also reduced the number of low-relevance hits.
Many of these changes are described in Interactive tools for functional annotation of bacterial genomes.
PaperBLAST cannot provide snippets for many of the papers that are
published in non-open-access journals. This limitation applies even if
the paper is marked as "free" on the publisher's web site and is
available in PubmedCentral or EuropePMC. If a journal that you publish
in is marked as "secret," please consider publishing elsewhere.
Many important articles are missing from PaperBLAST, either because
the article's full text is not in EuropePMC (as for many older
articles), or because the paper does not mention a protein identifier such as a locus tag, or because of PaperBLAST's heuristics. If you notice an
article that characterizes a protein's function but is missing from
PaperBLAST, please notify the curators at UniProt
or add an entry to GeneRIF.
Entries in either of these databases will eventually be incorporated
into PaperBLAST. Note that to add an entry to UniProt, you will need
to find the UniProt identifier for the protein. If the protein is not
already in UniProt, you can ask them to create an entry. To add an
entry to GeneRIF, you will need an NCBI Gene identifier, but
unfortunately many prokaryotic proteins in RefSeq do not have
corresponding Gene identifers.
References
PaperBLAST: Text-mining papers for information about homologs.
M. N. Price and A. P. Arkin (2017). mSystems, 10.1128/mSystems.00039-17.
Europe PMC in 2017.
M. Levchenko et al (2017). Nucleic Acids Research, 10.1093/nar/gkx1005.
Gene indexing: characterization and analysis of NLM's GeneRIFs.
J. A. Mitchell et al (2003). AMIA Annu Symp Proc 2003:460-464.
UniProt: the universal protein knowledgebase.
The UniProt Consortium (2016). Nucleic Acids Research, 10.1093/nar/gkw1099.
BRENDA in 2017: new perspectives and new tools in BRENDA.
S. Placzek et al (2017). Nucleic Acids Research, 10.1093/nar/gkw952.
The EcoCyc database: reflecting new knowledge about Escherichia coli K-12.
I. M. Keeseler et al (2016). Nucleic Acids Research, 10.1093/nar/gkw1003.
The MetaCyc database of metabolic pathways and enzymes.
R. Caspi et al (2018). Nucleic Acids Research, 10.1093/nar/gkx935.
CharProtDB: a database of experimentally characterized protein annotations.
R. Madupu et al (2012). Nucleic Acids Research, 10.1093/nar/gkr1133.
The carbohydrate-active enzymes database (CAZy) in 2013.
V. Lombard et al (2014). Nucleic Acids Research, 10.1093/nar/gkt1178.
The Transporter Classification Database (TCDB): recent advances
M. H. Saier, Jr. et al (2016). Nucleic Acids Research, 10.1093/nar/gkv1103.
REBASE - a database for DNA restriction and modification: enzymes, genes and genomes.
R. J. Roberts et al (2015). Nucleic Acids Research, 10.1093/nar/gku1046.
Deep annotation of protein function across diverse bacteria from mutant phenotypes.
M. N. Price et al (2016). bioRxiv, 10.1101/072470.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory