PaperBLAST
PaperBLAST Hits for sp|Q5UZ46|ASSY_HALMA Argininosuccinate synthase OS=Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) OX=272569 GN=argG PE=3 SV=1 (420 a.a., MPEGNGTVAL...)
Show query sequence
>sp|Q5UZ46|ASSY_HALMA Argininosuccinate synthase OS=Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) OX=272569 GN=argG PE=3 SV=1
MPEGNGTVALAFSGGLDTTVCVSLLKEEYGYDEVIGVTVDVGQPDYEFEEAEETAEALGV
EQHVVDATEEFADLCMEAVKANADYQGYPLGTALARPVIAKAILSVAEDEGCSAVAHGCT
GKGNDQLRFESVWRDSDLDVIAPVRELGLTREWENEYAAEKGLPVEGGDGGRYSIDTNLW
SRSIEGSELEDPSTIPADDIYKWTDNPSDKDAELVEVEFEDGVPVAVDGEELGGVELIEQ
LNKQAGAHGIGRTDMMEDRMLGLKVRENYEHPAATVLLTAHEALEGLVLTQEERQFKAQV
DQEWSQKAYQGLVDAPLTGALEAFIDDTNERVTGTVTVKLEGGHCRPVSRESDYAVYSES
AASFNEEDVSGGITQQDATGVAKYHGFQSRLANKILDDAKKGAAVTDGSGDHAASEDTEE
Running BLASTp...
Found 180 similar proteins in the literature:
HVO_0049 argininosuccinate synthase from Haloferax volcanii DS2
74% identity, 96% coverage
PF0207 argininosuccinate synthase from Pyrococcus furiosus DSM 3638
47% identity, 93% coverage
- An energy-conserving reaction in amino acid metabolism catalyzed by arginine synthetase
Michimori, Proceedings of the National Academy of Sciences of the United States of America 2024 - “...to T. kodakarensis , harbors genes encoding CPS (PF1713, PF1714) and the conventional argininosuccinate synthetase PF0207 and argininosuccinate lyase PF0208, suggesting that this archaeon can synthesize arginine from ornithine. The occurrence of these four genes is observed in seven genomes among the 40 Thermococcales sequences registered...”
- Thermococcus kodakarensis provides a versatile hyperthermophilic archaeal platform for protein expression
Scott, Methods in enzymology 2021 - “...( Atomi et al., 2004 ; Fukuda et al., 2008 ). The P. furiosus genes PF0207 and PF0208 encode argininosuccinate synthase and argininosuccinate lyase, respectively, which together catalyze the synthesis of arginine from citrulline or aspartate ( Farkas et al., 2013 ; Santangelo & Reeve, 2010...”
- “...5-FOA, respectively KU216, KW128, TS517, TS559, TS900 Sato et al. (2003) Citrulline, aspartate + argG (PF0207), + argH (PF0208) Minimal medium lacking citrulline and aspartate Any strain Atomi et al. (2004) Table 3 Promoters compatible with gene expression in T. kodakarensis . Promoter Gene ID Origin...”
- A mutant ('lab strain') of the hyperthermophilic archaeon Pyrococcus furiosus, lacking flagella, has unusual growth physiology
Lewis, Extremophiles : life under extreme conditions 2015 - “...the WT(Hale et al. 2008; Hale et al.). Several ORFs associated with aspartate metabolism (PF0121, PF0207, PF1056, PF1472) were down-regulated in the mutantvs. WT. At all three time points, Met biosynthesis (PF1266-1269) was down-regulated in the mutant; note that PF1267 and PF1268 had mutations corresponding to...”
- “...WT 10h 14h 24h Annotation Comment PF0121 9.2 17.1 18.4 aspartate aminotransferase PF0122 mutated (D) PF0207 2.5 2.6 9.8 argininosuccinate synthase PF0209 mutated (S) PF0333 4.0 14.9 2.1 flagella-related protein g Flagella biosynthesis; PF0332, PF0334, PF0337 mutated (FS) PF0335 4.3 16.0 3.7 flagella-related protein d PF0336...”
- Genetics Techniques for Thermococcus kodakarensis
Hileman, Frontiers in microbiology 2012 - “...additions Limited to minimal media; limited host range Sato et al. ( 2005 ) Arginine/citrulline PF0207, PF0208 Argininosuccinate synthase, argininosuccinate lyase Any strain No strain restrictions Limited to minimal media; requires supplementation with citrulline Santangelo and Reeve ( 2010b ) Agmatine TK0149 Pyruvoyl-dependent arginine decarboxylase TS559...”
- “...(Fukui et al., 2005 ). Introduction and expression of two genes from P. furiosus , PF0207 and PF0208 that encode argininosuccinate synthase and argininosuccinate lyase respectively, to the T. kodakarensis genome, or on a replicative plasmid (see below), were shown to provide any T. kodakarensis strain...”
- Novel multiprotein complexes identified in the hyperthermophilic archaeon Pyrococcus furiosus by non-denaturing fractionation of the native proteome
Menon, Molecular & cellular proteomics : MCP 2009 - “...Gene Annotation pI PF0042 PF0043 PF0207 PF0208 PF0495 PF0496 Metal-dependent hydrolase Phosphoenolpyruvate synthetase Argininosuccinate synthase...”
- Impact of substrate glycoside linkage and elemental sulfur on bioenergetics of and hydrogen production by the hyperthermophilic archaeon Pyrococcus furiosus
Chou, Applied and environmental microbiology 2007 - “...3.32 Glutamate metabolism PF0201 PF0202 PF0203 PF0204 PF0205 PF0206 PF0207 PF0450 PF1602 PF1852 3.42 3.72 5.82 2.82 4.12 2.92 2.12 35.92 4.2 1.92 2.42 2.12 4.02...”
- Whole-genome DNA microarray analysis of a hyperthermophile and an archaeon: Pyrococcus furiosus grown on carbohydrates or peptides
Schut, Journal of bacteriology 2003 - “...[Glutamate biosynthesis] PF0204 PF0205 PF0206 [Arginine biosynthesis] PF0207 PF0208 PF0209 PF0272 PF0371 PF0428 PF0429 PF0450 PF0464 PF0514 PF0651 [Unknown]...”
BLJ_0642 argininosuccinate synthase from Bifidobacterium longum subsp. longum JDM301
43% identity, 92% coverage
Igni_0635 argininosuccinate synthase from Ignicoccus hospitalis KIN4/I
46% identity, 86% coverage
- Multi-omics analysis provides insight to the Ignicoccus hospitalis-Nanoarchaeum equitans association
Rawle, Biochimica et biophysica acta. General subjects 2017 - “...t L-Ornithine m L-Citrulline m Igni_0171 Glutaminefructose-6-phosphate transaminase t Igni_1430 Argininosuccinate lyase t Fumarate m Igni_0635 Argininosuccinate synthase L-Citrulline m Note: Gene/proteins are listed by Ignicoccus gene identifiers with corresponding annotations. Metabolites are listed below enzymes that utilize or produce them. Type refers to the omic...”
alr4798 argininosuccinate synthase from Nostoc sp. PCC 7120
43% identity, 91% coverage
- Proteomic Insights into Starvation of Nitrogen-Replete Cells of Nostoc sp. PCC 7120 under β-N-Methylamino-L-Alanine (BMAA) Treatment
Koksharova, Toxins 2020 - “...enzyme cannot produce citrulline from arginine [ 47 ]. The next enzyme, argininosuccinate synthase (EC:6.3.4.5, alr4798 ), was downregulated ( Table 2 , Supplementary Figure S7 ). At the same time, urease [EC:3.5.1.5, alr3670 ] was upregulated. The enzyme phosphoglycerate mutase/phosphoserine phosphatase (PSP) (EC:3.1.3.3, alr3338 )...”
- “...subunit [EC:2.2.1.6] all4613 * Valine, leucine and isoleucine biosynthesis 0.51 0.0315 46 argininosuccinate synthase [EC:6.3.4.5] alr4798 Arginine biosynthesis Alanine, aspartate and glutamate metabolism 0.72 0.0704 47 phosphoserine phosphatase [EC:3.1.3.3] alr3338 Glycine, serine and threonine metabolism found only in control sample 0.0191 48 ornithine carbamoyltransferase [EC:2.1.3.3] alr4907...”
- Inactivation of agmatinase expressed in vegetative cells alters arginine catabolism and prevents diazotrophic growth in the heterocyst-forming cyanobacterium Anabaena
Burnat, MicrobiologyOpen 2014 - “...alr0540 ); 7, ornithine carbamoyltransferase ( alr4907 ); 8, arginine deiminase; 9, argininosuccinate synthetase ( alr4798 ); 10, argininosuccinate lyase ( alr3887 ). Note that no gene is annotated as encoding arginase or arginine deiminase. 2-OG, 2-oxoglutarate; [H], reducing power; P, energy-requiring reaction (energy provided by...”
B1W3B3 Argininosuccinate synthase from Streptomyces griseus subsp. griseus (strain JCM 4626 / CBS 651.72 / NBRC 13350 / KCC S-0626 / ISP 5235)
42% identity, 92% coverage
BSU29450 argininosuccinate synthase from Bacillus subtilis subsp. subtilis str. 168
44% identity, 91% coverage
- Comparison of Bacillus subtilis transcriptome profiles from two separate missions to the International Space Station
Morrison, NPJ microgravity 2019 - “...3.16 3.47 2.76 3.65 Unknown Unknown BSU29440 argH 2.57 2.67 1.25 1.22 Argininosuccinate lyase AhrC BSU29450 argG 2.50 2.61 1.29 1.30 Argininosuccinate synthase AhrC BSU30200 bioB 4.35 4.64 1.20 1.16 Biotin synthase BirA BSU30210 bioD 4.77 5.05 1.67 1.73 Dethiobiotin synthase BirA BSU30230 bioA 4.57 4.75...”
- Secondary structural entropy in RNA switch (Riboswitch) identification
Manzourolajdad, BMC bioinformatics 2015 - “...0.363 79 yopS BSU20780 0.847 55 3014345 3014501 reverse BSU29460 moaB -90 0.3694 79 argG BSU29450 0.847 56 749147 749303 forward BSU06780 yeeC -3069 0.363 550 yeeG BSU06820 0.846 57 665425 665581 forward BSU06130 ydjC -677 0.3439 1963 gutB BSU06150 0.846 58 2106272 2106428 reverse BSU19360...”
- “...0.363 79 yopS BSU20780 0.847 30 3014345 3014501 reverse BSU29460 moaB -90 0.3694 79 argG BSU29450 0.847 31 749147 749303 forward BSU06780 yeeC -3069 0.363 550 yeeG BSU06820 0.846 32 665425 665581 forward BSU06130 ydjC -677 0.3439 1963 gutB BSU06150 0.846 33 2106272 2106428 reverse BSU19360...”
GL331_18120 argininosuccinate synthase from Bacillus velezensis
44% identity, 91% coverage
argG / CAA88926.1 argininosuccinate synthetase from Streptomyces clavuligerus (see 3 papers)
BB341_RS23970, SCLAV_0796 argininosuccinate synthase from Streptomyces clavuligerus
42% identity, 92% coverage
ATE50_RS06345 argininosuccinate synthase from Bacillus velezensis
44% identity, 91% coverage
MAP_RS06945 argininosuccinate synthase from Mycobacterium avium subsp. paratuberculosis K-10
MAP1367 ArgG from Mycobacterium avium subsp. paratuberculosis str. k10
42% identity, 92% coverage
- Delineating transcriptional crosstalk between Mycobacterium avium subsp. paratuberculosis and human THP-1 cells at the early stage of infection via dual RNA-seq analysis
Park, Veterinary research 2022 - “...in the arginine biosynthesis pathway included argB (MAP_RS06925), argC (MAP_RS06915), argD (MAP_RS06930), argF (MAP_RS06935), argG (MAP_RS06945), argH (MAP_RS06950), and argJ (MAP_RS06920). Meanwhile, host arginine and proline metabolism-related gene sets were downregulated (Figure 5 B). This pathway included genes that are involved in catabolic reactions of arginine...”
- Description of a novel adhesin of Mycobacterium avium subsp. paratuberculosis
Viale, BioMed research international 2014 - “...S1 30S ribosomal protein S1 1,443 Gu et al., 2003 (Mtb) [ 36 ] 4 MAP1367 Rv1658 argG Argininosuccinate synthase 1,197 ND 5 MAP1889c Rv2145c wag31 DivIVA family protein 783 He and de Buck, 2010 (MAP) [ 34 ] 6 MAP1962 Rv2220 glnA1 Glutamine synthetase A1...”
- Proteome and differential expression analysis of membrane and cytosolic proteins from Mycobacterium avium subsp. paratuberculosis strains K-10 and 187
Radosevich, Journal of bacteriology 2007 - “...41398385 gi 41409122 MAP2450c MAP0494 MAP2679c MAP4336 MAP1367 MAP4232 MAP0790 MAP3694c MAP4130 MAP1310 MAP0658c MAP4233 MAP2891c MAP0789 MAP1894c MAP2246c...”
- “...MAP3872 MAP3832c MAP0011 MAP2013c MAP3047 MAP2057 MAP0435c MAP1367 MAP0980c 87.30 167.87 266.55 179.81 367.30 72.89 84.58 182.64 239.31 126.33 211.65 93.72...”
NCgl1346 argininosuccinate synthase from Corynebacterium glutamicum ATCC 13032
cg1586 argininosuccinate synthase from Corynebacterium glutamicum ATCC 13032
41% identity, 92% coverage
- Recent Advances of L-ornithine Biosynthesis in Metabolically Engineered Corynebacterium glutamicum
Wu, Frontiers in bioengineering and biotechnology 2019 - “...of ornithine carbamoyltransferase (encoded by argF / NCgl1344 ), argininosuccinate synthase (encoded by argG / NCgl1346 ), and argininosuccinate lyase (encoded by argH / NCgl1347 ). The genes encoding these enzymes are arranged in two operons, argCJBDFR and argGH . The two operons are repressed by...”
- Adaptation of Corynebacterium glutamicum to ammonium limitation: a global analysis using transcriptome and proteome techniques
Silberbach, Applied and environmental microbiology 2005 - “...NCgl1137 NCgl1340 NCgl1341 NCgl1342 NCgl1343 NCgl1344 NCgl1345 NCgl1346 NCgl1347 NCgl1446 NCgl2098 NCgl2528 cg0104 cg0113 cg0114 cg0115 cg0116 cg0117 cg0118...”
- Global expression profiling and physiological characterization of Corynebacterium glutamicum grown in the presence of L-valine
Lange, Applied and environmental microbiology 2003 - “...NCgl1347 Argininosuccinate lyase argH (C. glutamicum) 2623e NCgl1346 Argininosuccinate synthase argG (C. glutamicum) 2624e NCgl1345 Arginine repressor argR (C....”
- Functional Genomics Uncovers Pleiotropic Role of Rhomboids in Corynebacterium glutamicum
Luenenschloss, Frontiers in microbiology 2022 - “...and 40C, acetylglutamate kinase (Cg1582) in the CF and MF at 30C and argininosuccinate synthase (Cg1586) in the MF at 30 and 40C. Larger amounts of homocysteine methyltransferase (Cg1290), participating in methionine biosynthesis, were found in the MF at 30 and 40C, but the opposite in...”
- Functional genomics of pH homeostasis in Corynebacterium glutamicum revealed novel links between pH response, oxidative stress, iron homeostasis and methionine synthesis
Follmann, BMC genomics 2009 - “...carbamoyltransferase 0 1.75 -0.12 1.2 0.4 -0.2 - - - - - - ArgR 35 cg1586 v argG Argininosuccinate synthase 0 1.16 0.05 4.1 4.3 4.3 5.4 5.2 5.1 3.1 3.5 2.8 36 cg1626 w Hypothetical secreted protein 0 2.12 n.d. - - - - -...”
- Random mutagenesis in Corynebacterium glutamicum ATCC 13032 using an IS6100-based transposon vector identified the last unknown gene in the histidine biosynthesis pathway
Mormann, BMC genomics 2006 - “...e 2 Hypoxanthine cg2857 b purF (1) b Amidophosphoribosyltransferase Purine biosynthesis [93] f 5 Arginine cg1586 argG (1) Argininosuccinate synthase Arginine biosynthesis [94] 6 Phenylalanine cg2391 cg3207 aroG (2) pheA (4) Phospho-2-dehydro-3deoxyheptonate aldolase, Prephenate dehydratase Phenylalanine biosynthesis [95] [96] 16 Histidine cg2299 , cg2303 , cg2305...”
- Adaptation of Corynebacterium glutamicum to ammonium limitation: a global analysis using transcriptome and proteome techniques
Silberbach, Applied and environmental microbiology 2005 - “...cg1333 cg1334 cg1338 cg1580 cg1581 cg1582 cg1583 cg1584 cg1585 cg1586 cg1588 cg1697 cg2391 cg2900 codAb ureA ureB ureC ureE ureF ureG ureD gltB gltD dapD glnA...”
ASSY_SYNY3 / P77973 Argininosuccinate synthase; Argininosuccinate synthetase; Citrulline--aspartate ligase; SyArgG; EC 6.3.4.5 from Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa) (see paper)
slr0585 argininosuccinate synthetase from Synechocystis sp. PCC 6803
45% identity, 86% coverage
- function: Catalyzes the condensation of citrulline and aspartate into argininosuccinate, the immediate precursor of arginine (PubMed:38478146). SyArgG is the rate-limiting step in arginine biosynthesis in Synechocystis PCC 6803 (PubMed:38478146).
catalytic activity: L-citrulline + L-aspartate + ATP = 2-(N(omega)-L- arginino)succinate + AMP + diphosphate + H(+) (RHEA:10932)
subunit: Homotetramer. - Arginine inhibits the arginine biosynthesis rate-limiting enzyme and leads to the accumulation of intracellular aspartate in Synechocystis sp. PCC 6803
Katayama, Plant molecular biology 2024 - “...region containing the argininosuccinate synthetase open reading frame (ORF) in Synechocystis sp. PCC 6803 ( slr0585 ) was obtained from the KEGG database ( https://www.genome.jp/kegg/ ). A Bam HI- Xho I fragment was artificially synthesized by Eurofin Genomics Co. Ltd., and the resultant fragment was cloned...”
- “...and transformation of Synechocystis 6803 cells The open reading frames of Synechocystis 6803 argG ( slr0585 ) and argH ( slr1133 ) were synthesized and introduced into the Nde I- Eco RV sites of the pTKP2031 vector containing the psbAII promoter by Eurofin Genomics Japan. The...”
- Identification of the direct regulon of NtcA during early acclimation to nitrogen starvation in the cyanobacterium Synechocystis sp. PCC 6803
Giner-Lamia, Nucleic acids research 2017 - “...transport system substrate-binding protein 1233755c N sll1973 1576602 1576801 promoter 1.304 hypothetical protein 1576662 N slr0585 argG 3533652 3534001 promoter 1.276 argininosuccinate synthetase 3533815 N slr1735 bgtA 1317495 1317738 promoter 1.275 ATP-binding subunit of the ABC-type Bgt permease 1317670 N sll1968 pmgA 909452 909601 promoter 1.214...”
- Improved sugar-free succinate production by Synechocystis sp. PCC 6803 following identification of the limiting steps in glycogen catabolism
Hasunuma, Metabolic engineering communications 2016 - “...ppc (sll0920), involved in anaplerosis; and glnN (slr0288), glnA (slr1756), gad (sll1641), gltB (sll1502), argG (slr0585) and cysK (slr1842), involved in amino acid metabolism ( Table 2 ). Genes involved in light harvesting and in the photosystem, such as psbC (sll0851), psbB (slr0906), psaJ (sml0008), psaF...”
- “...2.41 2.69 ferredoxin-dependent glutamate synthase slr0343 petD 1.85 1.83 2.77 cytochrome B6-f complex subunit IV slr0585 argG 1.78 1.93 2.64 argininosuccinate synthase sll0166 hemD 1.76 2.23 1.26 uroporphyrin-III synthase sll1893 hisF 1.74 2.15 1.30 imidazole glycerol phosphate synthase subunit HisF slr1830 phbC 1.49 1.75 1.45 poly(3-hydroxyalkanoate)...”
- The nitrogen-regulated response regulator NrrA controls cyanophycin synthesis and glycogen catabolism in the cyanobacterium Synechocystis sp. PCC 6803
Liu, The Journal of biological chemistry 2014 - “...slr1859 slr1860 slr1861 sll2008 slr1367 sll2009 slr1022 slr0585 slr0073 sll0185 sll0550 Gene NrrA Controls Cyanophycin Synthesis and Glycogen Metabolism large...”
- “...AAATCGCCCATAGGTGT -3' 5'- CTATCCAGGCCAATGCTC -3' argG (slr0585) 5'- TGCCCTTACCAGTACAACC -3' 5'- CAGCCAGAAGAGGCAGAT -3' pilL (slr0073) 5'- CGCCATAGTTTGGGTAGA -3'...”
- Iron deprivation in Synechocystis: inference of pathways, non-coding RNAs, and regulatory elements from comprehensive expression profiling
Hernández-Prieto, G3 (Bethesda, Md.) 2012 - “...0.84 0.62 0.11 0.68 3.6410 7 0.69 sll1119-as4 1.23 1.36 0.17 0.19 0.63 7.0210 7 slr0585 Argininosuccinate synthetase 1.65 1.39 1.03 0.44 0.76 2.2510 6 0.74 slr0585-as3 1.71 1.76 0.34 0.10 0.78 1.1110 5 sll0083 Phosphoheptose isomerase 1.07 0.84 0.56 0.07 0.02 2.0910 5 0.78 sll0083-as1...”
- RNA-seq based identification and mutant validation of gene targets related to ethanol resistance in cyanobacterial Synechocystis sp. PCC 6803
Wang, Biotechnology for biofuels 2012 - “...slr0502 cobalamin synthesis protein cobW homolog 1.75 1.88 1.83 1.67 slr0574 cytochrome P450 2.34 2.41 slr0585 argininosuccinate synthetase 2.32 2.42 slr0618 cobyric acid synthase 1.69 1.56 slr0678 biopolymer transport ExbD like protein 2.19 2.26 slr0721 malic enzyme 1.67 2.29 slr0724 HtaR suppressor protein homolog 2.00 1.50...”
- Thioredoxin-linked processes in cyanobacteria are as numerous as in chloroplasts, but targets are different
Lindahl, Proceedings of the National Academy of Sciences of the United States of America 2003 - “...slr1463 sll0158 slr2076 sll0726 slr0009 sll1393 slr1176 slr0585 sll1099 sll1212 sll1994 sll0576 slr1198 sll1621 ssr3383 Gene product Apparent molecular mass,...”
FRAAL5202 Argininosuccinate synthase (Citrulline--aspartate ligase) from Frankia alni ACN14a
43% identity, 91% coverage
- Frankia alni Carbonic Anhydrase Regulates Cytoplasmic pH of Nitrogen-Fixing Vesicles
Pujic, International journal of molecular sciences 2023 - “...(rhizobactin-related metabolite; FRAAL6422- FRAAL6426); sodF (Fe-superoxide dismutase, FRAAL4337); accA (acetyl carboxylase, FRAAL3196); argF (argininosuccinate lyase, FRAAL5202) and two can (carbonic anhydrase; FRAAL1222, FRAAL4889). These two CANs belong to the Beta class prevalent in prokaryotes which is more active than the Gamma CANs [ 20 ]. The...”
- “...transmembrane protein, Oprn/Chp FRAAL5040 5472936 - Putative acetyltransferase protein FRAAL5142 5574524 cobS cobalamin 5-phosphate synthase FRAAL5202 5637735 argG Argininosuccinate synthase (Citrulline-aspartate ligase) FRAAL5248 5688660 - Putative integral membrane peptidase FRAAL5656 6113062 - D-amino acid dehydrogenase small subunit FRAAL5679 6141476 mobA molybdopterin-guanine dinucleotide biosynthesis protein (partial) FRAAL5702...”
GBAA4880 argininosuccinate synthase from Bacillus anthracis str. 'Ames Ancestor'
42% identity, 92% coverage
Rv1658 argininosuccinate synthase from Mycobacterium tuberculosis H37Rv
43% identity, 92% coverage
- Shotgun proteomic profiling of dormant, 'non-culturable' Mycobacterium tuberculosis
Nikitushkin, PloS one 2022 - “...the urea cycle may be broken because of the decreased level of argininosuccinate synthase ( Rv1658 , p < 0.05, log 2 FC = 0.69). To annotate precisely the metabolic pathways differentially preserved in dormancy, pathway enrichment analysis was carried out on the enzymatic proteins with...”
- Quantitative proteomics reveals that dormancy-related proteins mediate the attenuation in mycobacterium strains
Wang, Virulence 2021 - “...strain, namely, ArgC (Rv1652), ArgJ (Rv1653), ArgB (Rv1654), ArgD (Rv1655), ArgF (Rv1656), ArgR (Rv1657), ArgG (Rv1658), and ArgH (Rv1659), which may indicate that the H37Rv and H37Ra strains experience a deficiency in arginine during the stationary phase. The glyoxylate cycle is an alternative pathway used to...”
- Metabolomics reveals that the cAMP receptor protein regulates nitrogen and peptidoglycan synthesis in Mycobacterium tuberculosis
Liu, RSC advances 2020 - “...in citrulline abundance. Meanwhile, subsequent production of arginosuccinate from citrulline by arginosuccinate synthase argG ( rv1658 ) is also upregulated with the corresponding gene showing significant upregulation (log 2 FC = 1.39). N 2 -Succinyl- l -ornithine ( m / z 233.1132) was the breakdown intermediate...”
- Description of a novel adhesin of Mycobacterium avium subsp. paratuberculosis
Viale, BioMed research international 2014 - “...30S ribosomal protein S1 1,443 Gu et al., 2003 (Mtb) [ 36 ] 4 MAP1367 Rv1658 argG Argininosuccinate synthase 1,197 ND 5 MAP1889c Rv2145c wag31 DivIVA family protein 783 He and de Buck, 2010 (MAP) [ 34 ] 6 MAP1962 Rv2220 glnA1 Glutamine synthetase A1 1,437...”
- Osmosensory signaling in Mycobacterium tuberculosis mediated by a eukaryotic-like Ser/Thr protein kinase
Hatzios, Proceedings of the National Academy of Sciences of the United States of America 2013 - “...Rv1642 Rv1643 Rv1652 Rv1653 Rv1654 Rv1655 Rv1656 Rv1657 Rv1658 Rv1659 Rv1886c Rv1908c Rv1980c Rv1996 Rv2050 Rv2190c Rv2271 Rv2301 Rv2348c Rv2391 Rv2412 Rv2441c...”
- Adenylating enzymes in Mycobacterium tuberculosis as drug targets
Duckworth, Current topics in medicinal chemistry 2012 - “...hisS, ileS, leuS, lysS, lysX, metS, pheS, pheT, proS, serS, thrS, trpS, tyrS, valS Rv2555c, Rv1658, Rv1292, Rv2572c, Rv3580c, Rv2992, Rv2357c, Rv2580c, Rv1536, Rv0041, Rv3598c, Rv1640c, Rv1007c, Rv1649, Rv1650, Rv2845c, Rv3834c, Rv2614c, Rv3336c, Rv1689, Rv2448c Aminoacyl tRNA synthetase (Protein biosynthesis) yes (E) 2 acs Rv3667 Acetyl...”
SXYL_01961 argininosuccinate synthase from Staphylococcus xylosus
42% identity, 91% coverage
MAB_2342 Argininosuccinate synthase ArgG from Mycobacterium abscessus ATCC 19977
41% identity, 93% coverage
B1YJ35 Argininosuccinate synthase from Exiguobacterium sibiricum (strain DSM 17290 / CCUG 55495 / CIP 109462 / JCM 13490 / 255-15)
44% identity, 90% coverage
- HAMAP as SPARQL rules-A portable annotation pipeline for genomes and proteomes.
Bolleman, GigaScience 2020 - “...Web technology stack. Table 1: Simple protein-annotation associations of HAMAP rule MF_00005 for UniProtKB entry B1YJ35 Protein Annotation uniprot:B1YJ35 GO:0004055 uniprot:B1YJ35 GO:0005524 uniprot:B1YJ35 GO:0006526 uniprot:B1YJ35 GO:0005737 uniprot:B1YJ35 ec:6.3.4.5 uniprot:B1YJ35 rhea:10932 Results Validation We have tested the approach of executing rule-based annotation with a generic SPARQL engine...”
4xfjB / G7CBN9 Crystal structure of argininosuccinate synthase from mycobacterium thermoresistibile in complex with amppnp and arginine
41% identity, 92% coverage
- Ligands: phosphoaminophosphonic acid-adenylate ester; arginine (4xfjB)
MSMEG_3770 argininosuccinate synthase from Mycobacterium smegmatis str. MC2 155
41% identity, 92% coverage
- MnoSR removal in Mycobacterium smegmatis triggers broad transcriptional response to 1,3-propanediol and glucose as sole carbon sources
Płocińska, Frontiers in cellular and infection microbiology 2024 - “...of MnoSR significantly upregulated the expression of the arg operon consisting of seven genes ( msmeg_3770 to msmeg_3776 ) encoding proteins required for arginine biosynthesis (ArgG, ArgR, ArgF, ArgD, ArgB, ArgJ and ArgC), participating in nitrogen metabolism: nitrogen transfer in the urea Krebs cycle and in...”
- Genome-Wide Transcriptional Response of Mycobacterium smegmatis MC2155 to G-Quadruplex Ligands BRACO-19 and TMPyP4
Shitikov, Frontiers in microbiology 2022 - “...products are used in the urea cycle to produce arginine under the action of ArgG (MSMEG_3770) in conjunction with ArgF (MSMEG_3772) and ArgH (MSMEG_3769) enzymes. Discussion Here, we employed RNA-seq analysis to demonstrate the impact of G4-ligands, BRACO-19 and TMPyP4, on M. smegmatis transcription and elucidate...”
- Protein Composition of Mycobacterium smegmatis Differs Significantly Between Active Cells and Dormant Cells With Ovoid Morphology
Trutneva, Frontiers in microbiology 2018 - “...porphyrin synthesis (MSMEG_0953, MSMEG_0956, and MSMEG_2780), leucine synthesis (MSMEG_6271 and MSMEG_2379) and arginine synthesis (MSMEG_3769, MSMEG_3770, MSMEG_3773, and MSMEG_3774). Dormant cells evidently accumulate storage materials: we found several enzymes responsible for the synthesis and accumulation of glycogen (MSMEG_4918), trehalose (MSMEG_6514 and MSMEG_6515 unique; Supplementary Table S2...”
lmo2090 similar to argininosuccinate synthase from Listeria monocytogenes EGD-e
43% identity, 91% coverage
- The stressosome is required to transduce low pH signals leading to increased transcription of the amino acid-based acid tolerance mechanisms in Listeria monocytogenes
Guerreiro, Access microbiology 2022 - “...encoding the arginine biosynthesis pathway, the argCJBDF operon ( lmo1591lmo1587 , respectively) and argGH ( lmo2090 and lmo2091 , respectively) [ 18, 29 ]. Interestingly, Cheng and colleagues demonstrated that ArgR also binds to the promoter region of rsbV at the rsbVW-sigB-rsbX operon and suppresses the...”
- Comparison of widely used Listeria monocytogenes strains EGD, 10403S, and EGD-e highlights genomic variations underlying differences in pathogenicity
Bécavin, mBio 2014 - “...in BHI ( 85 ). The three remaining genes, argC ( lmo1591 ), argG ( lmo2090 ), and lmo0640 , have to our knowledge never been described in PrfA regulation studies. In EGD, the number of genes expressed differently (128 genes) compared to EGD-e under reference...”
- Transcriptomic response of Listeria monocytogenes to iron limitation and Fur mutation
Ledala, Applied and environmental microbiology 2010 - “...7.47 3.2 2.47 Amino acid biosynthesis lmo2090 lmo2091 lmo2252 Argininosuccinate synthase (argG) Argininosuccinate lyase (argH) Aspartate aminotransferase (aspB)...”
T303_00025 argininosuccinate synthase from Streptococcus thermophilus ASCC 1275
41% identity, 92% coverage
- Proteomic analysis reveals potential factors associated with enhanced EPS production in Streptococcus thermophilus ASCC 1275
Padmanabhan, Scientific reports 2020 - “...T303_06400 1.65 0.053 DOWN Arginine, cysteine, methionine Glutamatecysteine ligase T303_07930 2.36 0.040 UP Argininosuccinate synthase T303_00025 1.91 0.048 DOWN Urease subunit alpha T303_02590 1.05 0.052 UP Glutamate dehydrogenase T303_03260 2.15 0.069 UP Cysteine synthase T303_02960 2.42 0.096 UP Ribosomal proteins 50S ribosomal protein L22 T303_00600 1.39...”
- Transcriptomic Insights Into the Growth Phase- and Sugar-Associated Changes in the Exopolysaccharide Production of a High EPS-Producing Streptococcus thermophilus ASCC 1275
Padmanabhan, Frontiers in microbiology 2018 - “...Genes responsible for tryptophan synthesis (T303_08760, T303_08765, T303_08770, T303_08775 T303_08780, T303_08785, T303_08790), arginine biosynthesis (T303_00020, T303_00025) and valine/leucine/isoleucine biosynthesis (T303_06860, T303_06865, T303_06875, T303_06880) were significantly upregulated in L5h when compared to other two sugars. FIGURE 8 Changes in expression of genes associated with ammo acid metabolism....”
LLNZ_00730 argininosuccinate synthase from Lactococcus cremoris subsp. cremoris NZ9000
41% identity, 92% coverage
- Genomics and transcriptomics analysis reveals the mechanism of isobutanol tolerance of a laboratory evolved Lactococcus lactis strain
Gupta, Scientific reports 2020 - “...synthase subunit beta Biosynthesis of amino acids 5 LLNZ_05015 Phosphoribosylformylglycinamidine synthase II Purine metabolism 6 LLNZ_00730 Argininosuccinate synthase Arginine biosynthesis 7 LLNZ_06600 Acetolactate synthase catalytic subunit Valine, leucine and isoleucine biosynthesis 8 LLNZ_07350 Sucrose-specific PTS system IIBC component Phosphotransferase system (PTS) 9 LLNZ_01385 Fructose-1,6-bisphosphatase class 3...”
- “...in 4B0 culture due to CodY downregulation. S. No Locus_tag Annotation LogFC KEGG pathway 1 LLNZ_00730 Argininosuccinate synthase 5.7 Arginine biosynthesis 2 LLNZ_10425 ABC-type oligopeptide transport system, periplasmic component 5.12 Peptide uptake 3 LLNZ_05325 Anthranilate phosphoribosyltransferase 4.98 Phenylalanine, tyrosine and tryptophan biosynthesis 4 LLNZ_05020 Amidophosphoribosyltransferase 4.77...”
llmg_0138 ArgG protein from Lactococcus lactis subsp. cremoris MG1363
41% identity, 92% coverage
Vpar_1568 argininosuccinate synthase from Veillonella parvula DSM 2008
41% identity, 91% coverage
TTX_0123 argininosuccinate synthase from Thermoproteus tenax Kra 1
44% identity, 92% coverage
LOC108992980 argininosuccinate synthase, chloroplastic from Juglans regia
42% identity, 78% coverage
- Metabolomics and Transcriptomics Analyses Reveals the Molecular Regulatory Mechanisms of Walnut (Juglans regia L.) Embryos in Response to Shade Treatment
Liang, International journal of molecular sciences 2023 - “...DAP in the shaded group compared to the control group. The genes encoding argininosuccinate synthase (LOC108992980), aminoacylase (LOC108997369), ATP-dependent 6-phosphofructokinase 3 (LOC109003738), and phosphoglycerate kinase (LOC109011248) were significantly downregulated at 90 DAP in the shaded group compared to the control group. The genes encoding glutamine synthetase...”
- “...beta subunit 2 (LOC108987199). Glutamine (pos-M147T48_2) was negatively correlated with aminoacylase (LOC108997369) and argininosuccinate synthase (LOC108992980). L-Citrulline (neg-M174T42) was positively correlated with anthranilate synthase beta subunit 2 (LOC108987199). In addition, the protein content increased from 18.51% in the control group to 24.12% in the shaded group...”
SE0657 argininosuccinate synthase from Staphylococcus epidermidis ATCC 12228
SERP_RS02815 argininosuccinate synthase from Staphylococcus epidermidis RP62A
41% identity, 91% coverage
Teth39_0229 argininosuccinate synthase from Thermoanaerobacter ethanolicus ATCC 33223
42% identity, 91% coverage
ILP78_10355 argininosuccinate synthase from Staphylococcus aureus
40% identity, 91% coverage
- Transcriptomic and Biochemical Analysis of the Antimicrobial Mechanism of Lipopeptide Iturin W against <i>Staphylococcus aureus</i>
Ji, International journal of molecular sciences 2024 - “...to the proton motive force [ 25 , 26 ]. In our study, the gene ILP78_10355 encoding arginine succinate synthetase and the gene argH encoding arginine succinate lyase were significantly down-regulated, up to 2 7 -fold, in C 14 iturin W-treated cells, and the gene argF...”
- “...Gene 4 g/mL log 2 FoldChange 24 g/mL log 2 FoldChange Gene Description ROS-related genes ILP78_10355 6.115 7.143 argininosuccinate synthase argH 7.100 6.613 argininosuccinate lyase argF 1.965 2.346 ornithine carbamoyltransferase ILP78_00430 2.230 2.689 superoxide dismutase ILP78_01305 1.248 1.693 glutathione peroxidase proton motive force mnhA2 0.776 1.207...”
XP_002521168 argininosuccinate synthase, chloroplastic from Ricinus communis
43% identity, 78% coverage
spr0102 Argininosuccinate synthase from Streptococcus pneumoniae R6
41% identity, 94% coverage
SPD_0110 argininosuccinate synthase from Streptococcus pneumoniae D39
41% identity, 94% coverage
Q2QVC1 argininosuccinate synthase from Oryza sativa subsp. japonica
42% identity, 80% coverage
- SWATH-MS-based quantitative proteomics reveals a uniquely intricate defense response in Cnaphalocrocis medinalis-resistant rice
Cheah, Scientific reports 2020 - “...C. medinalis herbivory. Based on the functional information in UniProt, four proteins (Q851S8, Q6F361, Q2QLX5, Q2QVC1) were associated with amino acid biosynthesis and are highlighted in cluster 2 (Fig. 2b ). The expression levels of these proteins were lower in Qingliu than in TN1 at 0,...”
- “...another set of amino acid biosynthetic enzymes (Q69RJ0, Q10NY1, Q5VNW0, Q7Y096, Q6L4H5, Q10NW0, Q6KAJ2, Q2QLX5, Q2QVC1) was discovered to be induced in Qingliu in comparison with TN1 at either 24 or 72h of insect herbivory (Supplementary Table S4b ). For instance, the expression of cysteine synthase...”
- iTRAQ-based proteome profile analysis of superior and inferior Spikelets at early grain filling stage in japonica Rice
You, BMC plant biology 2017 - “...5.200.10 3.931.24 ns 70 Os09g0255400 Q8H3R5 Putative indole-3-glycerol phosphate synthase 3.820.69 ns ns 85 Os12g0235800 Q2QVC1 Argininosuccinate synthase, chloroplast, putative, expressed 2.740.13 ns ns 92 Os03g0136200 Q10S41 Methyltransferase 0.420.04 ns ns 93 Os12g0607000 Q2QME6 Homocysteine S-methyltransferase 3 3.830.20 ns ns 105 Os12g0138900 Q2QXY9 2-isopropylmalate synthase B,...”
Q6GIC7 Argininosuccinate synthase from Staphylococcus aureus (strain MRSA252)
SAR0923 putative argininosuccinate synthase from Staphylococcus aureus subsp. aureus MRSA252
DA471_RS02560 argininosuccinate synthase from Staphylococcus aureus
40% identity, 91% coverage
- Antibacterial Activity and Multi-Targeted Mechanism of Action of Suberanilic Acid Isolated from Pestalotiopsis trachycarpicola DCL44: An Endophytic Fungi from Ageratina adenophora
Wen, Molecules (Basel, Switzerland) 2024 - “...0.000162841 A0A850FXK9 cysK Cysteine synthase 0.707 Down 0.015964978 Q6GDG7 arcA Arginine deiminase 0.301 Down 0.001221858 Q6GIC7 argG Argininosuccinate synthase 0.147 Down 7.32963 10 6 Q6GAW6 argH Argininosuccinate lyase 0.404 Down 5.68 10 5 Membrane transport Q6GH18 pstS Phosphate-binding protein PstS 1.544 Up 0.009992197 A0A660A2T8 cycB Maltodextrin-binding...”
- “...9 Q6GJB4 ilvE 0.681 0.088087529 0.723 Consistency 10 Q6GDG7 arcA 0.301 0.001021429 0.154 Consistency 11 Q6GIC7 argG 0.147 0.001274761 0.012 Consistency 12 Q6GH18 pstS 1.544 0.093222288 1.783 Consistency 13 A0660A2T8 cycB 0.799 0.199271957 0.797 Consistency 14 Q5HEP0 vraR 0.816 0.965351503 1.006 Consistency 15 A6QJ83 rpsQ 1.443...”
- Multi-Omics Analysis Reveals Anti-Staphylococcus aureus Activity of Actinomycin D Originating from Streptomyces parvulus
Lin, International journal of molecular sciences 2021 - “...the amino acid metabolism enzymes, such as 3-dehydroquinate dehydratase (Q8NXI0), 1-pyrroline-5-carboxylate dehydrogenase (Q8NUR2), argininosuccinate synthase (Q6GIC7), argininosuccinate lyase (Q8NXF3), 4,4-diaponeurosporen-aldehyde dehydrogenase (Q2FWX9), aminomethyltransferase (Q6GGG20), glycine cleavage system H protein (Q6GII3), ornithine aminotransferase 2 (Q6GAW9), 2-oxoglutarate dehydrogenase E1 component (Q6GGZ5), dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex...”
- Interplay of Nitric Oxide Synthase (NOS) and SrrAB in Modulation of Staphylococcus aureus Metabolism and Virulence
James, Infection and immunity 2019 - “...SAR2493 (narT) SAR2714 (arcA) SAR2713 (arcB) SAR0184 (argJ) SAR0923 (argG) SAR1142 (otc) SAR2255 (rocF) 0.84 0.06 1.16 0.09 0.84 0.10 nos srrAB mutan/pMK4 1.11...”
- Silversol® (a Colloidal Nanosilver Formulation) Inhibits Growth of Antibiotic-Resistant Staphylococcus aureus by Disrupting Its Physiology in Multiple Ways
Thakkar, Pharmaceutics 2024 - “...Table 1 Primer sequences for the target genes. Gene ID/Name Primers Amplicon Size (bp) argG (DA471_RS02560) FP: 5-TCAAAACCTATGGGGCAGAG-3 233 RP: 5-TTCCGATACCATGCTTACCA-3 argH (DA471_RS02555) FP: 5-TGCAACTATGCTTGCGAATC-3 189 RP: 5-TGCAACTTACCACCAGCATC-3 rpsU (DA471_RS07645) (Control gene) FP: 5-AATGAATCACTTGAAGATGCGTTA-3 150 RP: 5-TTTGAATTTACGTTTACGTGCAG-3 pharmaceutics-16-00726-t002_Table 2 Table 2 Staphylococcus aureus challenged with antibiotics...”
- “...family protein 4 0.0003 1 3 DA471_RS09790 - DUF1270 domain-containing protein 3.69 0.0003 NA 4 DA471_RS02560 argG Argininosuccinate synthase 3.28 0.002 7 5 DA471_RS11145 Spa Staphylococcal protein A 3.26 0.002 NA 6 DA471_RS02555 argH Argininosuccinate lyase 3.15 0.002 5 7 DA471_RS02685 - Minor capsid protein 3.08...”
NWMN_0832 argininosuccinate synthase from Staphylococcus aureus subsp. aureus str. Newman
SA0822 argininosuccinate synthase from Staphylococcus aureus subsp. aureus N315
SAOUHSC_00899 argininosuccinate synthase from Staphylococcus aureus subsp. aureus NCTC 8325
SAUSA300_0864 argininosuccinate synthase from Staphylococcus aureus subsp. aureus USA300_FPR3757
SACOL0964 argininosuccinate synthase from Staphylococcus aureus subsp. aureus COL
BTN44_08010, NWMN_RS04695 argininosuccinate synthase from Staphylococcus aureus subsp. aureus str. Newman
40% identity, 91% coverage
- Sulfide Homeostasis and Nitroxyl Intersect via Formation of Reactive Sulfur Species in Staphylococcus aureus
Peng, mSphere 2017 - “...Sodium/proton antiporter family protein NWMN_0831 SA0821 argH 3.0 Argininosuccinate lyase (Arg biosynthesis) /+ down d NWMN_0832 SA0822 argG 6.2 Argininosuccinate synthase (Arg biosynthesis) /+ down d NWMN_0907 SA0890 6.5 Hypothetical NWMN_1047 SA0983 isdG 3.1 f Heme-degrading monooxygenase NWMN_1066 SA1000 5.1 Hypothetical (fibrinogen binding) NWMN_1068 SA1002 5.6...”
- Sulfide Homeostasis and Nitroxyl Intersect via Formation of Reactive Sulfur Species in Staphylococcus aureus
Peng, mSphere 2017 - “...antiporter family protein NWMN_0831 SA0821 argH 3.0 Argininosuccinate lyase (Arg biosynthesis) /+ down d NWMN_0832 SA0822 argG 6.2 Argininosuccinate synthase (Arg biosynthesis) /+ down d NWMN_0907 SA0890 6.5 Hypothetical NWMN_1047 SA0983 isdG 3.1 f Heme-degrading monooxygenase NWMN_1066 SA1000 5.1 Hypothetical (fibrinogen binding) NWMN_1068 SA1002 5.6 Hypothetical...”
- Mutation of RNA polymerase β-subunit gene promotes heterogeneous-to-homogeneous conversion of β-lactam resistance in methicillin-resistant Staphylococcus aureus
Aiba, Antimicrobial agents and chemotherapy 2013 - “...SA1996 SA2486 Amino acid transport and metabolism SA0822 SA0850 Terpenoid metabolism SA1304 Secretion and other transport system SA0956 SA2203 SA2442 SA2443...”
- An RpoB mutation confers dual heteroresistance to daptomycin and vancomycin in Staphylococcus aureus
Cui, Antimicrobial agents and chemotherapy 2010 - “...urea cycle SA0175 SA0176 SA0177 SA0178 SA0179 SA0821 SA0822 SA2082 SA2083 SA2084 SA2085 SA2086 SA2087 SA2088 SA2428 SA2429 Galactose metabolism SA0123 SA0236...”
- Overexpression of genes of the cell wall stimulon in clinical isolates of Staphylococcus aureus exhibiting vancomycin-intermediate- S. aureus-type resistance to vancomycin
McAleese, Journal of bacteriology 2006 - “...SA0145 SA0276 SA1602 SA0010 SA0178 SA0179 SA0180 SA0821 SA0822 SA1272 SA1674 SA1675 SA2135 SA2255 SA2425 SA2427 SA2428 SA0668 SA0199 SA0200 SA0847 SA2251 SA2252...”
- Characterization of the Staphylococcus aureus heat shock, cold shock, stringent, and SOS responses and their effects on log-phase mRNA turnover
Anderson, Journal of bacteriology 2006 - “...SA0641 SA0692 SA0703 SA0730 SA0755 SA0768 SA0785 SA0821 SA0822 SA0870 SA0871 SA0920 SA1033 SA1044 SA1101 SA1117 SA1191 SA1200 SA1375 SA1418 SA1556 SA1658 SA1659...”
- The roles of cell wall inhibition responsive protein CwrA in the pathogenicity of <i>Staphylococcus aureus</i>
Han, Virulence 2024 - “...lacB Galactose-6-phosphate isomerase subunit; LacB 2.4 SAOUHSC_02455 lacA Galactose-6-phosphate isomerase subunit; LacA 1.9 Arginine biosynthesis SAOUHSC_00899 argG Argininosuccinate synthase; ArgG 6.8 SAOUHSC_00898 argH Argininosuccinate lyase; ArgH 6.3 2-Oxocarboxylic acid metabolism SAOUHSC_02281 Dihydroxy-acid dehydratase 1.7 Nitrogen metabolism SAOUHSC_02671 narK Putative nitrate transporter; NarK 1.9 SAOUHSC_02679 narJ Probable...”
- Transcriptomic analyses reveal the potential antibacterial mechanism of citral against Staphylococcus aureus
Liao, Frontiers in microbiology 2023 - “...mcsB ATP:guanido phosphotransferase SAOUHSC_00505 6.484127314 0 clpC endopeptidase Down-regulated SAOUHSC_02671 6.471783081 1.611E-128 narT nitrate transporter SAOUHSC_00899 6.02947604 3.46374E-83 argG argininosuccinate synthase SAOUHSC_00188 5.983619288 2.0165E-102 pflA pyruvate formate-lyase 1 activating enzyme SAOUHSC_00187 5.900147115 1.4499E-168 pflB formate acetyltransferase SAOUHSC_02685 5.845924926 2.22966E-93 sirohydrochlorin ferrochelatase SAOUHSC_02681 5.770892267 8.0905E-128 nitrate reductase...”
- Regulation of neutrophil myeloperoxidase inhibitor SPIN by the small RNA Teg49 in Staphylococcus aureus
Cengher, Molecular microbiology 2022 - “...(glycerol) SAOUHSC_02130 0.39 2.15E-18 1.28E-16 yebG Hypothetical protein with NETI domain (YebG-like, DNA damage sensing) SAOUHSC_00899 0.35 3.08E-23 2.95E-21 argG Argininosuccinate synthase SAOUHSC_02662 0.29 3.80E-16 1.90E-14 scrA PTS system sucrose-specific transporter subunit IIBC Notes : RNA-Seq performed with wild type Staphylococcus aureus SH1000, a Teg49 mutant,...”
- Teg58, a small regulatory RNA, is involved in regulating arginine biosynthesis and biofilm formation in Staphylococcus aureus
Manna, Scientific reports 2022 - “...synthase, ctrA 4998 12,820 2.56 Arginine biosynthesis pathway SAOUHSC_00898 Argininosuccinate lyase, argH 9081 46,012 5.06 SAOUHSC_00899 Argininosuccinate synthase, argG 6770 31,658 4.67 SAOUHSC_01787 Arginine permease, lysP 42,011 10,666 3.94 SAOUHSC_02558 Urease subunit gamma, ureA 2734 641 4.26 SAOUHSC_02559 Urease subunit beta, ureB 3408 737 4.62 SAOUHSC_02561...”
- Functional analysis of the EsaB component of the Staphylococcus aureus Type VII secretion system
Casabona, Microbiology (Reading, England) 2017 - “...SAOUHSC_01936 splE 6.3 Serine protease SplE 3.3 SAOUHSC_02454 lacB 6.3 Galactose-6-phosphate isomerase subunit LacB 3.4 SAOUHSC_00899 argG 6.2 Argininosuccinate synthase ns SAOUHSC_02108 ftn 6.1 Ferritin ns SAOUHSC_00368 6.1 Unknown, hypothetical protein ns SAOUHSC_00411 5.9 Unknown, hypothetical protein 2.2 SAOUHSC_01951 epiC 5.8 Epidermin biosynthesis protein EpiC ns...”
- The Staphylococcus aureus KdpDE two-component system couples extracellular K+ sensing and Agr signaling to infection programming
Xue, Infection and immunity 2011 - “...SAOUHSC_03013 SAOUHSC_01030 SAOUHSC_00465 SAOUHSC_00898 SAOUHSC_00899 SAOUHSC_02118 SAOUHSC_01191 SAOUHSC_01216 SAOUHSC_01218 SAOUHSC_00195 SAOUHSC_00196...”
- Advantage of upregulation of succinate dehydrogenase in Staphylococcus aureus biofilms
Gaupp, Journal of bacteriology 2010 - “...(SAOUHSC_01128); ArgG, argininosuccinate synthase (SAOUHSC_00899); ArgH, argininiosuccinate lyase (SAOUHSC_00898); Arg, arginase (SAOUHSC_02409); UreA,...”
- The Staphylococcus aureus GGDEF domain-containing protein, GdpS, influences protein A gene expression in a cyclic diguanylic acid-independent manner
Shang, Infection and immunity 2009 - “...SAOUHSC_02971 SAOUHSC_00317 SAOUHSC_00557 SAOUHSC_00627 SAOUHSC_00831 SAOUHSC_00898 SAOUHSC_00899 SAOUHSC_00762 spa sarH1/ sarS pyrR pyrP pyrB pyrC pyrAA carB...”
- Differential gene expression in Staphylococcus aureus exposed to Orange II and Sudan III azo dyes
Pan, Journal of industrial microbiology & biotechnology 2015 - “...0.0263 Cytoplasmic 2.06 SAUSA300_2385 SAUSA300_1231 SAUSA300_0864 SAUSA300_2538 SAUSA300_1808 SAUSA300_1916 SAUSA300_0914 SAUSA300_2006 ilvD EG Amino acid...”
- “...amino acid metabolism. Particularly, argG (SAUSA300_0864) encoding cytoplasmic argininosuccinate synthase and ilvD (SAUSA300_2006) encoding dihydroxy-acid...”
- CcpA regulates arginine biosynthesis in Staphylococcus aureus through repression of proline catabolism
Nuxoll, PLoS pathogens 2012 - “...(acetylornithine transaminase), SAUSA300_0187, EC 2.6.1.11; argF (ornithine carbamoyl transferase), SAUSA300_1062, EC 2.1.3.3; argG (argininosuccinate synthase), SAUSA300_0864, EC 6.3.4.5; and argH (argininosuccinate lyase), SAUSA300_0863, EC 4.3.2.1. However, as previously reported and confirmed in this study, S. aureus is a functional arginine auxotroph when grown on complex laboratory...”
- Role of the accessory gene regulator agr in community-associated methicillin-resistant Staphylococcus aureus pathogenesis
Cheung, Infection and immunity 2011 - “...SAUSA300_0311 SAUSA300_0312 SAUSA300_0313 SAUSA300_0863 SAUSA300_0864 SAUSA300_1062 SAUSA300_1063 SAUSA300_1712 SAUSA300_1713 SAUSA300_1714 spa lrgA lrgB...”
- Staphylococcus aureus gene expression in a rat model of infective endocarditis
Hanses, Genome medicine 2014 - “...30.1 43.5 27.6 43.1 arginine/ornithine antiporter argG SACOL0963 ns ns 3.4 6.4 argininosuccinate synthase argH SACOL0964 ns ns 5.4 13.3 argininosuccinate lyase deoB SACOL0124 4.0 2.2 4.4 2.3 phosphopentomutase deoD SACOL0121 7.1 7.8 8.9 10.0 purine nucleoside phosphorylase gltA SACOL1742 6.9 -6.7 4.8 -9.4 citrate synthase...”
- A new oxidative sensing and regulation pathway mediated by the MgrA homologue SarZ in Staphylococcus aureus
Chen, Molecular microbiology 2009 - “...Conserved hypothetical protein Genes upregulated in the sarZ mutant SACOL1783 acs 2.2 - Acetyl-CoA synthetase SACOL0964 argG 8.2 Arguininosuccinate synthetase SACOL0963 argH 5.6 Arguininosuccinate lyase SACOL1429 asd 4.4 Aspartate-semialdehyde dehyrogenase SACOL0121 deoD 5.2 + Purine nucreoside phospholylase SACOL1872 epiE 3.0 Epidermin immunity protein E SACOL1873 epiF...”
- Combined transcriptome and metabolome analysis revealed the antimicrobial mechanism of Griseorhodin C against Methicillin-resistant Staphylococcus aureus
Liao, Scientific reports 2024 - “...kinase (CK) BTN44_06880 Arg F Down -3.527296328 Ornithine carbamoyltransferase BTN44_08015 / Down -2.863552121 Argininosuccinate lyase BTN44_08010 Arg G Down -2.544841558 Argininosuccinate synthase BTN44_02145 nos Down -1.43424776 Nitric oxide synthase oxygenase BTN44_06145 / Up 2.382079164 Glutamine synthetase BTN44_13885 Ure B Up 1.196165129 Urease subunit beta BTN44_05360 Ald...”
- Global Transcriptomic Analysis of Bacteriophage-Host Interactions between a Kayvirus Therapeutic Phage and Staphylococcus aureus
Finstrlová, Microbiology spectrum 2022 - “...26.63 13.53 n.s. n.s. NWMN_RS13230 Sirohydrochlorin chelatase SirB 22.27 10.99 n.s. n.s. Amino acid metabolism NWMN_RS04695 Argininosuccinate synthase ArgG 2.71 3.37 n.s. n.s. NWMN_RS06110 Ornithine carbamoyltransferase ArgF 4.63 3.67 3.36 ( P = 0.1) 20.68 NWMN_RS06115 Carbamate kinase ArcC1 2.40 2.79 3.77 20.56 NWMN_RS07005 Threonine synthase...”
SGO_0175 argininosuccinate synthase from Streptococcus gordonii str. Challis substr. CH1
41% identity, 91% coverage
Q9SZX3 Argininosuccinate synthase, chloroplastic from Arabidopsis thaliana
42% identity, 78% coverage
- STIC2 selectively binds ribosome-nascent chain complexes in the cotranslational sorting of Arabidopsis thylakoid proteins
Stolle, The EMBO journal 2024 - “...AT3G47520.1 s, m, l P12859 Glyceraldehyde-3-phosphate dehydrogenase B (G3PB) Carbohydrate Psat5g010520.1 AT1G42970.1 s, m, l Q9SZX3 Argininosuccinate synthase (ASSY) Amino acid Psat0s3176g0120.1 Psat4g065240.1 AT4G24830.1 s, m, l m (2.67) Q8L7R2 Homoserine kinase (KHSE) Amino acid Psat2g000800.1 AT2G17265.1 s, m, l Q93ZN9 LL-diaminopimelate aminotransferase (DAPAT) Amino acid...”
- Sexual and Apogamous Species of Woodferns Show Different Protein and Phytohormone Profiles
Fernández, Frontiers in plant science 2021 - “...1,088 39629-404_3_ORF2 [3] 133 Q42601 0 1.32 2.6 3 Argininosuccinate synthase 740 1466-1535_4_ORF1 [4] 52 Q9SZX3 0 1.00 7.1 3 Prohibitin-3 372 25450-498_6_ORF2 [5] 31 O04331 1.6594E-147 1.00 15 5 Acetyl-CoA carboxylase 1 1,122 1892-1420_1_ORF2 [3] 265 Q38970 0 1.22 12 28 Nucleoid-associated protein At2g24020 145...”
- Gel-based proteomic map of Arabidopsis thaliana root plastids and mitochondria
Grabsztunowicz, BMC plant biology 2020 - “...Acetylglutamate kinase 92 Q9SCL7, At3g57560 Acetylornithine aminotransferase 62, 63 Q9M8M7, At1g80600 Argininosuccinate synthase 51, 52 Q9SZX3, At4g24830 ATP phosphoribosyltransferase 1 62 Q9S762, At1g58080 Bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase 30 Q9SQT8, At3g06350 Bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase 64, 66 Q9SIE1, At2g22250 Branched-chain-amino-acid aminotransferase 3 64, 66 Q9M401,...”
SSA_2142 Argininosuccinate synthase, putative from Streptococcus sanguinis SK36
41% identity, 91% coverage
- Glucose Phosphotransferase System Modulates Pyruvate Metabolism, Bacterial Fitness, and Microbial Ecology in Oral Streptococci
Zeng, Journal of bacteriology 2023 (secret) - Transcriptome, Phenotypic, and Virulence Analysis of Streptococcus sanguinis SK36 Wild Type and Its CcpA-Null Derivative (ΔCcpA)
Bai, Frontiers in cellular and infection microbiology 2019 - “...c184_g26 b , c , m SSA_2133 145.08 92.99 1.01 0.01598 c184_g30 b , c SSA_2142 36.71 10.44 1.55 0.03134 a Genes associated with putative cre-sites . b GO classification:biological process(BP) . c GO classification: cellular component(CC) . m GO classification: molecular function(MF) . Figure 1...”
- Involvement of signal peptidase I in Streptococcus sanguinis biofilm formation
Aynapudi, Microbiology (Reading, England) 2017 - “...at least 1.5-fold changes and P -value <0.001, we identified the genes ( SSA_2141 and SSA_2142 ) involved in arginine metabolism, as shown by the KEGG database ( http://www.genome.jp/kegg/ ), to be transcriptionally down-regulated. As for the up-regulated mRNA transcripts, it was shown that the genes...”
- “...No SSA_0670 0.595 1.42E-19 Hypothetical protein No SSA_1032 0.638 4.68E-12 30S ribosomal protein S20 No SSA_2142 0.649 1.09E-18 Argininosuccinate synthase No SSA_2141 0.657 3.25E-11 Argininosuccinate lyase No SSA_1098 0.658 1.32E-08 Formate/nitrate transporter No SSA_2206 1.502 7.86E-06 Hypothetical protein No SSA_2149 1.504 2.94E-06 Hypothetical protein No SSA_0620...”
SAN_0156 argininosuccinate synthase from Streptococcus agalactiae COH1
39% identity, 92% coverage
- Global transcriptional profiling reveals Streptococcus agalactiae genes controlled by the MtaR transcription factor
Bryan, BMC genomics 2008 - “...Serine protease 2.3 10 -7 -3.20 SAN_1255 Streptokinase-like 1.4 10 -5 -2.65 Amino acid biosynthesis SAN_0156 ( argG ) Argininosuccinate synthase 8.6 10 -5 -2.60 SAN_0157 ( argH ) Argininosuccinate lyase 8.7 10 -6 -2.91 Energy metabolism SAN_0597 ( manB ) Phosphomannomutase or Phosphoglucomutase 4.1 10...”
- “...SAN_1755 -6.0 -3.7 GCAGATGAGGTAGAACAGTGG GTGCGGTAATGTGACCTTTATC SAN_2186 -3.7 -3.2 AATATAAGTTAGGTGCCGTATCTG CGTGTTGTTAGTAGGTGTCTC SAN_1255 -3.2 -2.7 AAACCCAAATCCTCACATTATTG TCCCATCTTTACATTGACTTCG SAN_0156 -1.7 -2.6 ATATAAAGGTTCTGCCAAAGTC TGTATAAGTTGCTAAGTTCTCATC SAN_0157 -2.8 -2.9 TTGGACATCATCTAATGGCTTAC ATATGGCGGTCAATAGGAAATG SAN_0597 -2.1 -2.0 GGCGGGATTGAGAGGTAAAC TAACGGACATCATAACTAACTGC SAN_0933 +1.7 +2.5 CAGAAATAAGGCATCAACTACC AAAGAATAGGCATTATCAATACG Complementation analysis The mtaR mutant bears a kanamycin cassette insertion in...”
XP_002311011 argininosuccinate synthase, chloroplastic from Populus trichocarpa
43% identity, 78% coverage
- Proteome Analysis of Poplar Seed Vigor
Zhang, PloS one 2015 - “...19 Glutamine synthetase XP_002301683 160 31 2/6 45/6.2 40/6.0 +2.06 +2.42 Nitrogen 12 Argininosuccinate synthase XP_002311011 320 30 4/14 52/6.4 55/6.3 +1.85 (+1.22) 29 Probable pyridoxal biosynthesis protein PDX1 XP_002308219 152 30 2/10 33/6.8 33/6.3 +1.52 +1.73 Sugar/poly- saccharide 21 ATP phosphoribosyltransferase* XP_002325923 214 20 6/10...”
B4FZ29 argininosuccinate synthase from Zea mays
42% identity, 86% coverage
LOC110703812 argininosuccinate synthase, chloroplastic-like from Chenopodium quinoa
42% identity, 77% coverage
- Transcriptome and Metabolome Analyses Reveal Mechanisms Underlying the Response of Quinoa Seedlings to Nitrogen Fertilizers
Li, International journal of molecular sciences 2023 - “...comparison with CK. In CK vs. LN, GLUD1_2 [EC:1.4.1.3] gene- LOC110704768 , ASS1 [EC:6.3.4.5] gene- LOC110703812 , and rbcL [EC:4.1.1.39] novel 420 expression significantly decreased. ACY1 [EC3.5.1.14] novel 7764 , ASNS [EC:6.3.5.4] gene- LOC110720129 , gene- LOC110693243 , ppdK [EC:2.7.9.1] gene- LOC110719952 , and gene- LOC110690041...”
- “...results, and the RT-qPCR results of six genes (gene- LOC110689260 , gene- LOC110694697 , gene- LOC110703812 , gene- LOC110704768 , gene- LOC110710546 , and gene- LOC110714529 ) were consistent with RNA-seq data( Table 2 ). This showed that the transcriptome sequencing results were reliable ( Figure...”
lp_0775 argininosuccinate synthase from Lactiplantibacillus plantarum WCFS1
lp_0775 argininosuccinate synthase from Lactobacillus plantarum WCFS1
41% identity, 94% coverage
- Molecular Responses of Lactobacilli to Plant Phenolic Compounds: A Comparative Review of the Mechanisms Involved
López, Antioxidants (Basel, Switzerland) 2021 - “...copA : copper-transporting ATPase TA [ 64 ] + Human/mouse GIT passage [ 95 ] lp_0775 argG : argininosuccinate synthase TA [ 64 ] + Mouse GIT passage [ 88 , 90 ] lp_3473 ram2 : alpha- l -rhamnosidase TA [ 64 ] + Mouse GIT...”
- Lactobacillus plantarum WCFS1 and its host interaction: a dozen years after the genome
van, Microbial biotechnology 2016 - “...oxidative and redox imbalance (Bron etal ., 2004a ). In addition, the genes lp_0237 and lp_0775 were found to be bileinducible. Overall, 62 and 28 openreading frames are up or downregulated respectively. Among the upregulated genes are the oxidative stressassociated glutathione reductase and the metCcysK operon...”
- Tannic acid-dependent modulation of selected Lactobacillus plantarum traits linked to gastrointestinal survival
Reverón, PloS one 2013 - “...treated with: 0.5 mM tannic acid 2 mM tannic acid Genes linked to GI-tract survival lp_0775 ( argG ) argininosuccinate synthase 1.93 2.76 e lp_3055 (copA ) copper transporting ATPase 1.71 2.86 e lp_3473 ( ram2 ) alpha-L-rhamnosidase 2.34 3.19 e lp_2940 cell surface protein, LPXTG-motif...”
- Spatial and temporal expression of Lactobacillus plantarum genes in the gastrointestinal tracts of mice
Marco, Applied and environmental microbiology 2007 - “...Berkeley a ivi gene lp_0017 lp_0237 lp_0419 lp_0775 lp_0800 lp_1019 lp_1164 lp_1403 lp_1603 lp_2940 lp_3055 lp_3176 lp_3473 lp_3660 lp_3662 lp_0006 lp_0537...”
- Genetic characterization of the bile salt response in Lactobacillus plantarum and analysis of responsive promoters in vitro and in situ in the gastrointestinal tract
Bron, Journal of bacteriology 2004 - “...and five regulatory factors. Moreover, the lp_0237 and lp_0775 genes, identified here as genes that are inducible by bile in vitro, were previously identified...”
- “...genes confirmed that the expression level of lp_0237 and lp_0775 was significantly higher in cells grown in the presence of bile and cells isolated from the...”
- Identification of Lactobacillus plantarum genes that are induced in the gastrointestinal tract of mice
Bron, Journal of bacteriology 2004 - “...lp_0017c (proA) lp_0228e (pepD1) lp_0696 lp_0775 (argG) lp_0854a,c (birA2) Glutamate-5-semialdehyde dehydrogenase Dipeptidase Cytosine/adenosine deaminase...”
Saci_1617 arginosuccinate synthase from Sulfolobus acidocaldarius DSM 639
39% identity, 92% coverage
- Early Response of Sulfolobus acidocaldarius to Nutrient Limitation
Bischof, Frontiers in microbiology 2018 - “...saci_0755 ) (Figure 6 and Supplementary Table S2 ). Further, transcript levels of argG ( saci_1617 , argininosuccinate synthase), argH (argininosuccinate lyase), speA ( saci_1363 , arginine decarboxylase), speB [ saci_0863 (arginase family enzyme)] and speE ( saci_0643 , Spermidine synthase) were reduced (Supplementary Table S2...”
A0A438K994 argininosuccinate synthase from Vitis vinifera
42% identity, 29% coverage
LMB90_RS03525 argininosuccinate synthase from Limosilactobacillus reuteri
41% identity, 90% coverage
H9BG20 argininosuccinate synthase (EC 6.3.4.5) from Leishmania donovani (see 2 papers)
41% identity, 92% coverage
A4I066 argininosuccinate synthase (EC 6.3.4.5) from Leishmania infantum (see paper)
XP_003860931 argininosuccinate synthase, putative from Leishmania donovani
41% identity, 92% coverage
A8J506 argininosuccinate synthase from Chlamydomonas reinhardtii
40% identity, 87% coverage
CAC0973 Argininosuccinate synthase from Clostridium acetobutylicum ATCC 824
CA_C0973, CEA_G0984 argininosuccinate synthase from Clostridium acetobutylicum EA 2018
41% identity, 91% coverage
- Capturing the response of Clostridium acetobutylicum to chemical stressors using a regulated genome-scale metabolic model
Dash, Biotechnology for biofuels 2014 - “...lyase CAC2390 N-acetyl-gamma-glutamyl-phosphate reductase High CAC0974 Argininosuccinate lyase CAC2389 Acetylglutamate kinase (ACGK) Tertiary (K=3) Low CAC0973 Argininosuccinate synthase (ARGSS) CAC2389 Acetylglutamate kinase Med CAC0973 Argininosuccinate synthase CAC2389 Acetylglutamate kinase High CAC0973 Argininosuccinate synthase Quaternary (K=4) [minimal effect on biomass] Low CAC2391 or CAC3020 Bifunctional ornithine acetyltransferase/N-acetylglutamate...”
- “...PyrR/uracil phosphoribosyltransferase (UPRT) Med [minimal effect on biomass] CAC0109 and CAC0110 Sulfate adenylyltransferase (SAT) High CAC0973 Argininosuccinate synthase Secondary (K=2) Low No core set Med No core set High CAC0316 Ornithine carbamoyltransferase CAC2389 Acetylglutamate kinase Tertiary (K=3) Low No core set Med No core set High...”
- The role of PerR in O2-affected gene expression of Clostridium acetobutylicum
Hillmann, Journal of bacteriology 2009 - “...CAC3657 CAC3658 CAC3659 Arginine biosynthesis CAC0316 CAC0376 CAC0973 CAC0974 CAC2388 CAC2389 CAC2390 CAC2391 Protein function COG class O2 sufB1 sufB2...”
- “...to CAC2712, CAC3075 and CAC3076, CAC3657 to CAC3659, CAC0973 and CAC0974, and CAC2388 to CAC2391 are genes that presumably form a transcriptional unit,...”
- Elucidation of the roles of adhE1 and adhE2 in the primary metabolism of Clostridium acetobutylicum by combining in-frame gene deletion and a quantitative system-scale approach
Yoo, Biotechnology for biofuels 2016 (no snippet) - Comparative genomic and transcriptomic analysis revealed genetic characteristics related to solvent formation and xylose utilization in Clostridium acetobutylicum EA 2018
Hu, BMC genomics 2011 - “...ornithine carbomoyltransferase CEA_G0390 CA_C0380 -4.23921 5.06975 5.365591 5.142555 3.394778 2.099342 periplasmic amino acid-binding protein CEA_G0984 CA_C0973 -4.67305 6.390879 8.78089 7.141168 3.889621 2.522783 argininosuccinate synthase CEA_G0985 CA_C0974 -4.03279 6.033303 8.738086 7.66813 4.662246 3.462605 argininosuccinate lyase CEA_G2392 CA_C2377 -4.81354 -4.50847 -4.89131 -5.25303 -5.6598 -6.94396 oligopeptide ABC-type transporter, periplasmic...”
- “...2.037144 ornithine carbomoyltransferase CEA_G0390 CA_C0380 -4.23921 5.06975 5.365591 5.142555 3.394778 2.099342 periplasmic amino acid-binding protein CEA_G0984 CA_C0973 -4.67305 6.390879 8.78089 7.141168 3.889621 2.522783 argininosuccinate synthase CEA_G0985 CA_C0974 -4.03279 6.033303 8.738086 7.66813 4.662246 3.462605 argininosuccinate lyase CEA_G2392 CA_C2377 -4.81354 -4.50847 -4.89131 -5.25303 -5.6598 -6.94396 oligopeptide ABC-type transporter,...”
FQP81_07870 argininosuccinate synthase from Pseudoalteromonas distincta
41% identity, 92% coverage
CD1785 argininosuccinate synthase from Clostridium difficile 630
42% identity, 85% coverage
- The current riboswitch landscape in <i>Clostridioides difficile</i>
Badilla, Microbiology (Reading, England) 2024 - “...CD3540 Methionine-tRNA ligase Amino acid metabolism CD0989 2-Isopropylmalate synthase CD1580 Homoserine dehydrogenase CD1580* Homoserine dehydrogenase CD1785 Argininosuccinate synthase CD2034 N -Acetyl-gamma-glutamyl-phosphate reductase CD2118 Threonine synthase CD2500 Argininosuccinate lyase CD2611 Bifunctional 5-methylthioadenosine/S-adenosylhomocysteine nucleosidase CD2695 Aspartate-ammonia ligase Amino acid transporter CD0750 ATP binding cassette (ATP)-type transport system, aminoacid-family...”
CPE0691 argininosuccinate synthase from Clostridium perfringens str. 13
40% identity, 92% coverage
ZMO1036 argininosuccinate synthase from Zymomonas mobilis subsp. mobilis ZM4
40% identity, 93% coverage
RSP_1212 ArgG, Argininosuccinate synthase from Rhodobacter sphaeroides 2.4.1
40% identity, 91% coverage
GSU0153 argininosuccinate synthase from Geobacter sulfurreducens PCA
39% identity, 91% coverage
Cbei_4515 argininosuccinate synthase from Clostridium beijerincki NCIMB 8052
39% identity, 94% coverage
RL2987 putative argininosuccinate synthase from Rhizobium leguminosarum bv. viciae 3841
38% identity, 91% coverage
AL01_09265 argininosuccinate synthase from Bombella intestini
40% identity, 93% coverage
DR0674 arginosuccinate synthase from Deinococcus radiodurans R1
38% identity, 94% coverage
ASSY_THEMA / Q9X2A1 Argininosuccinate synthase; Citrulline--aspartate ligase; EC 6.3.4.5 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
TM1780 argininosuccinate synthase from Thermotoga maritima MSB8
39% identity, 91% coverage
SPO0018 argininosuccinate synthase from Ruegeria pomeroyi DSS-3
39% identity, 91% coverage
- A mutant fitness assay identifies bacterial interactions in a model ocean hot spot
Schreier, Proceedings of the National Academy of Sciences of the United States of America 2023 - “...significantly influenced in the multibacterial treatments Gene Protein name (Gene symbol) Function Rp+V Rp+M Rp+V+M SPO0018 argininosuccinate synthase ( argG ) Arginine 3.5 3 SPO0332 argininosuccinate lyase ( argH ) Arginine 2.8 SPO0422 2-isopropylmalate synthase ( leuA ) Leucine 0.6 SPO0210 3-isopropylmalate dehydrogenase ( leuB )...”
CJE0767 argininosuccinate synthase from Campylobacter jejuni RM1221
38% identity, 92% coverage
- Integrated Genomic and Proteomic Analyses of High-level Chloramphenicol Resistance in Campylobacter jejuni
Li, Scientific reports 2017 - “...F, and G, all of which belong to NADH dehydrogenase in the oxidative phosphorylation process. Cje0767, like cje0766, was also down-regulated by 20-fold in resistant strains, and corresponded to an NAD(P)H-dependent oxidoreductase that was not included in the KEGG pathway. These results revealed that resistant strains...”
- “...metabolism in Campylobacter . Resistant strains disable an unknown metabolic pathway regulated by cje0766 and cje0767 and switch to NADH dehydrogenase complex I in the oxidative phosphorylation pathway. NADH dehydrogenase and ATP synthase were both up-regulated by two-fold. Second, the import of methionine was increased by...”
Cj0665c argininosuccinate synthase from Campylobacter jejuni subsp. jejuni NCTC 11168
38% identity, 92% coverage
lpg0494 argininosuccinate synthase from Legionella pneumophila subsp. pneumophila str. Philadelphia 1
39% identity, 92% coverage
- Complementation of Arginine Auxotrophy for Genetic Transformation of Coxiella burnetii by Use of a Defined Axenic Medium
Sandoz, Applied and environmental microbiology 2016 - “...L. pneumophila contains argDEFGH with argG (lpg0494, argininosuccinate synthase), argH (lpg0495, argininosuccinate lyase), and argF (lpg0496, ornithine...”
- Small Regulatory RNA and Legionella pneumophila
Faucher, Frontiers in microbiology 2011 - “...lpr0015 425773 425602 171 lpg0384 Weissenmayer et al. ( 2011 ) lpr0016 532291 532155 136 lpg0494 Weissenmayer et al. ( 2011 ) lpr0017 539616 539866 250 lpg0499, lpg0500 Weissenmayer et al. ( 2011 ) lpr0018 662203 662439 236 lpg0626 Weissenmayer et al. ( 2011 ) lpr0019...”
- ArgR-regulated genes are derepressed in the Legionella-containing vacuole
Hovel-Miner, Journal of bacteriology 2010 - “...of L-arginine biosynthesis from L-ornithine; argF (lpg0496), argG (lpg0494), and argH (lpg0495), whose transcript levels are up by as much as 100-fold in the...”
- “...predicted to encode an amino acid ABC transporter, and lpg0494 to -0496 are predicted to encode the final steps of L-arginine biosynthesis (A). The biosynthetic...”
PAE2884 argininosuccinate synthase (argG) from Pyrobaculum aerophilum str. IM2
48% identity, 67% coverage
SO_0278 argininosuccinate synthase from Shewanella oneidensis MR-1
40% identity, 92% coverage
K3G22_18080 argininosuccinate synthase from Shewanella putrefaciens
40% identity, 92% coverage
A7ML85 Argininosuccinate synthase from Cronobacter sakazakii (strain ATCC BAA-894)
39% identity, 95% coverage
TTC1701 No description from Thermus thermophilus HB27
41% identity, 91% coverage
- Integrative and Conjugative Element ICETh1 Functions as a Pangenomic DNA Capture Module in Thermus thermophilus
Blesa, Microorganisms 2020 - “...and a putative serine protease, respectively, were found inserted between the HB27 genes TTC1700 and TTC1701 in clone T3. As above, this seems to be the consequence of recombination events with homologues of the latter genes, acting as recombination arms in a genetic organization similar to...”
- “...genes TTHA0285 and TTH0A286 integrated in clone T3 by recombination with the conserved TTC1700 and TTC1701 genes. Interestingly, in the analyzed derivatives of the HB8 strain (T9-13), the large regions transferred correspond only to the boundaries of the selection marker, whereas only a few additional SNPs...”
VV1_1373 argininosuccinate synthase from Vibrio vulnificus CMCP6
40% identity, 91% coverage
NSCAC_0583 argininosuccinate synthase from Candidatus Nitrosacidococcus tergens
38% identity, 91% coverage
PflSS101_1161 argininosuccinate synthase from Pseudomonas lactis
38% identity, 92% coverage
- Lipopeptide biosynthesis in Pseudomonas fluorescens is regulated by the protease complex ClpAP
Song, BMC microbiology 2015 - “...ribonuclease R 1.27 1.27 PflSS101_0920 hisC_1 histidinol-phosphate transaminase 1.3 1.2 PflSS101_0926 mqo_1 malate_quinone-oxidoreductase 1.32 1.21 PflSS101_1161 argG argininosuccinate synthase 1.3 1.2 PflSS101_1203 TIGR00730 family protein 1.22 1.22 PflSS101_1209 fpr_2 ferredoxin--NADP+ reductase 1.28 1.24 PflSS101_1348 fabD acyl-carrier-protein S-malonyltransferase 1.26 1.32 PflSS101_1554 LamB_YcsF family protein 1.25 1.27 PflSS101_1626...”
PA3525 argininosuccinate synthase from Pseudomonas aeruginosa PAO1
PA14_18740 argininosuccinate synthase from Pseudomonas aeruginosa UCBPP-PA14
38% identity, 92% coverage
- Massively parallel mutant selection identifies genetic determinants of <i>Pseudomonas aeruginosa</i> colonization of <i>Drosophila melanogaster</i>
Miles, mSystems 2024 - “...Amino acids [E] PA5323 argB Amino acids [E] + PA0662 argC Amino acids [E] + PA3525 argG Amino acids [E] + PA3537 argF Amino acids [E] PA5263 argH Amino acids [E] PA3118 leuB Amino acids [E] + PA3121 leuC Amino acids [E] PA5495 thrB Amino acids...”
- The P-Type ATPase PA1429 Regulates Quorum-Sensing Systems and Bacterial Virulence
Zhang, Frontiers in microbiology 2017 - “...number Description Max fold Increased expression 649619 PA0590 ( apaH ) Bis (5-nucleosyl)-tetraphosphatase 2 3945216 PA3525 ( argG ) Argininosuccinate synthase 3 4218710 PA3763( purL ) Phosphoribosylformylglycinamidine synthase 3 3767022 PA3356( pauA 5) Glutamylpolyamine synthetase 3 1557569 PA1429 Probable cation-transporting P-type ATPa 4 5450147 PA4854( purH...”
- A systems-level approach for investigating Pseudomonas aeruginosa biofilm formation
Xu, PloS one 2013 - “...cycle Rxn#34 : L-Aspartate + ATP + L-Citrulline AMP + N(omega)-(L-Arginino)succinate + H+ + Diphosphate PA3525 ( argG ) arginine metabolism Rxn#35 : Acetate + ATP + Coenzyme A Acetyl-CoA + AMP + Diphosphate PA4733 ( acsB ) acetate metabolism Rxn#36 : 2 ATP + L-Glutamine...”
- Toxicogenomic response of Pseudomonas aeruginosa to ortho-phenylphenol
Nde, BMC genomics 2008 - “...PA0009 2.568 0.000361 glycyl-tRNA synthetase alpha chain gly Q Amino acid biosynthesis and metabolism PA3525_argG_at PA3525 2.45 0.0411 argininosuccinate synthase arg G Amino acid biosynthesis and metabolism PA3167_serC_at PA3167 2.345 0.0396 3-phosphoserine aminotransferase ser C Amino acid biosynthesis and metabolism PA0904_lysC_at PA0904 2.337 0.00528 aspartate kinase...”
- Cystic fibrosis sputum supports growth and cues key aspects of Pseudomonas aeruginosa physiology
Palmer, Journal of bacteriology 2005 - “...biosynthesis PA0035 PA0036 PA0904 PA1326 PA3118 PA3120 PA3121 PA3525 PA3537 PA4588 PA4695 PA4696 PA5035 PA5036 Genea P. AERUGINOSA GROWTH IN CF SPUTUM VOL. 187,...”
- Transcriptome analysis of the ArgR regulon in Pseudomonas aeruginosa
Lu, Journal of bacteriology 2004 - “...PA5152 PA5153 PA5154 PA5155 PA5170 PA5171 PA5172 PA5173 PA3525 PA3537 PA3538 PA4588 PA4756 PA4757 PA4758 PA5035 PA5036 Gene name VOL. 186, 2004 TRANSCRIPTOME...”
- “...91 91 422 79 PA5152 PAO1 PAO501 123 44 677 56 PA3525 (argG) PAO1 PAO501 52 106 20 102 Glu Glu Arg fusion, pAG1 (Fig. 2), that covers the intergenic region...”
- Characterization of nutrient-induced dispersion in Pseudomonas aeruginosa PAO1 biofilm
Sauer, Journal of bacteriology 2004 - “...Gene product Gene ontology Fold changea PA5117 PA3531 PA3525 PA4442 PA0223 PA3635 PA3155 PA1838 PA1338 PA1553 PA4333 PA3621 PA1584 PA1609 PA3806 PA3722 PA1913...”
- Pseudomonas aeruginosa core metabolism exerts a widespread growth-independent control on virulence
Panayidou, Scientific reports 2020 - “...( thrC ) + 17 Arginine biosynthesis (pau00220) PA14_08480 ( argC ) + NT 18* PA14_18740 ( argG ) + NT 19 PA14_18610 ( argF ) NT + 20 Glycolysis/Gluconeogenesis (pau00010) PA14_66310 ( aceF ) + NT 21* PA14_66290 ( aceE ) + NT 22 Cysteine...”
- A global genomic approach uncovers novel components for twitching motility-mediated biofilm expansion in Pseudomonas aeruginosa
Nolan, Microbial genomics 2018 - “...PA14_04640 (downstream of pfpI ), PA14_50080 , PA14_50100 , PA14_50110 (downstream of fliG ) and PA14_18740 (downstream of motY ). Where there was more than one transposon mutant available in the PA14 mutant collection [ 47 ], the most N-terminal transposon insertion mutant was selected. The...”
- Pseudomonas aeruginosa Genomic Structure and Diversity
Klockgether, Frontiers in microbiology 2011 - “...family transcriptional regulator 1558205 A G PA14_18150 syn. acsL Putative acetyl-CoA synthetase 1612742 A G PA14_18740 syn. argG Argininosuccinate synthase 1640196 G T PA14_18985 P H Hypothetical protein 1640394 A G PA14_18985 F S Hypothetical protein 1880872 C G PA14_21690 A G lhr1 Putative ATP-dependent DNA...”
CHLNCDRAFT_52216 hypothetical protein from Chlorella variabilis
E1ZF33 argininosuccinate synthase from Chlorella variabilis
39% identity, 86% coverage
- Real-time iTRAQ-based proteome profiling revealed the central metabolism involved in nitrogen starvation induced lipid accumulation in microalgae
Rai, Scientific reports 2017 - “...bifunctional protein ArgJ, chloroplastic CHLNCDRAFT_135738 1.4070.55 NS 2.8772.32 5. E1ZF33 Putative uncharacterized protein (arginine biosynthesis) CHLNCDRAFT_52216 1 1.5630.96 1.7971.13 1.4460.64 6. E1ZEF2 Cysteine synthase CHLNCDRAFT_145435 3 1.3170.24 1.8040.03 2.0650.02 7. E1ZP71 3-isopropylmalate dehydrogenase CHLNCDRAFT_56307 1 1.1900.52 1.6260.75 1.4850.97 8. E1Z6E6 Peptidyl-prolyl cis-trans isomerase CHLNCDRAFT_29941 1 1.2240.47...”
- Real-time iTRAQ-based proteome profiling revealed the central metabolism involved in nitrogen starvation induced lipid accumulation in microalgae
Rai, Scientific reports 2017 - “...2.3140.32 1.8910.26 4. E1ZIW5 Arginine biosynthesis bifunctional protein ArgJ, chloroplastic CHLNCDRAFT_135738 1.4070.55 NS 2.8772.32 5. E1ZF33 Putative uncharacterized protein (arginine biosynthesis) CHLNCDRAFT_52216 1 1.5630.96 1.7971.13 1.4460.64 6. E1ZEF2 Cysteine synthase CHLNCDRAFT_145435 3 1.3170.24 1.8040.03 2.0650.02 7. E1ZP71 3-isopropylmalate dehydrogenase CHLNCDRAFT_56307 1 1.1900.52 1.6260.75 1.4850.97 8. E1Z6E6...”
- “...intracellular nitrogen homeostasis. 6 , 49 , 50 2 Amino acid biosynthesis 9 E1ZPZ3, E1Z4T9, E1ZF33, A0A087SJX6, A0A087SKJ2, E1ZEF2, E1ZIW5, E1Z357, E1ZP71 To maintain the overall intracellular levels of nitrogen, amino acid biosynthesis particularly of aspartate, glutamate and arginine is elevated. Accumulation of arginine is the...”
PITG_05374 argininosuccinate synthase from Phytophthora infestans T30-4
39% identity, 78% coverage
PP1088, PP_1088 argininosuccinate synthase from Pseudomonas putida KT2440
38% identity, 92% coverage
- Gene expression reprogramming of Pseudomonas alloputida in response to arginine through the transcriptional regulator ArgR
Molina-Henares, Microbiology (Reading, England) 2024 - “...dioxygenase subunit + PP_0326 soxG sarcosine oxidase subunit gamma + PP_0328 fdhA formaldehyde dehydrogenase + PP_1088 argG arginine synthesis + PP_1741 betX choline/betaine/carnitine transport + PP_2184 formate dehydrogenase subunit beta + PP_0103 cytochrome c oxidase subunit (aa3) PP_0711 ycaC-I putative hydrolase PP_0806 lapF adhesin PP_2359 putative...”
- UEG Week 2024 Poster Presentations
, United European gastroenterology journal 2024 - UEG Week 2023 Poster Presentations
, United European gastroenterology journal 2023 - Genome-Wide Analysis of Targets for Post-Transcriptional Regulation by Rsm Proteins in Pseudomonas putida
Huertas-Rosales, Frontiers in molecular biosciences 2021 - “...below). However, the inverse was true for two of the tested fusions, those corresponding to PP_1088 ( argG , involved in arginine synthesis; Ramos-Gonzlez et al., 2016 ) and PP_4482 (part of the gene cluster encoding the main arginine transporter and its regulator; Barrientos-Moreno et al.,...”
- Arginine as an environmental and metabolic cue for cyclic diguanylate signalling and biofilm formation in Pseudomonas putida
Barrientos-Moreno, Scientific reports 2020 - “...P. putida mt-2, cured of pWWO PRCC a argG Null mutant derivative of KT2440 in PP_1088 ( argG ) 10 argH Null mutant derivative of KT2440 in PP_0184 ( argH ) 10 argT Null mutant derivative of KT2440 in PP_4486 ( argT ) This work artJ...”
- Arginine Biosynthesis Modulates Pyoverdine Production and Release in Pseudomonas putida as Part of the Mechanism of Adaptation to Oxidative Stress
Barrientos-Moreno, Journal of bacteriology 2019 (secret) - Genetic Dissection of the Regulatory Network Associated with High c-di-GMP Levels in Pseudomonas putida KT2440
Ramos-González, Frontiers in microbiology 2016 - “...family cfcK-59 PP_0015 Putative GTP-binding protein (AAA+ ATPase domain) cfcK-66 d ++/- e +/- e PP_1088 ( argG ) Argininosuccinate synthase cfcK-71 + ++ + PP_4169 ( gpsA ) NAD(P)H-dependent glycerol-3-phosphate dehydrogenase cfcK-74 (2) - d ++ + PP_0184 ( argH ) Argininosuccinate lyase cfcK-77 +...”
- A two-component regulatory system integrates redox state and population density sensing in Pseudomonas putida
Fernández-Piñar, Journal of bacteriology 2008 - “...(glyA) PP_0323 (soxB) PP_0324 (soxD) PP_0325 (soxA) PP_1088 (argG) PP_1110 PP_1111 PP_1112 PP_1113 PP_1654 (cysM) PP_5029 (hutG) PP_5030 (hutI) PP_5032 (hutH)...”
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CPH89_RS16850 argininosuccinate synthase from Pseudomonas fluorescens
38% identity, 92% coverage
VZ55_RS10120 argininosuccinate synthase from Gluconobacter oxydans
39% identity, 95% coverage
ASSY_THET8 / P59846 Argininosuccinate synthase; Citrulline--aspartate ligase; EC 6.3.4.5 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see 2 papers)
TTHA0284 argininosuccinate synthetase from Thermus thermophilus HB8
41% identity, 91% coverage
- catalytic activity: L-citrulline + L-aspartate + ATP = 2-(N(omega)-L- arginino)succinate + AMP + diphosphate + H(+) (RHEA:10932)
subunit: Homotetramer. - Genome-wide comprehensive analysis of transcriptional regulation by ArgR in Thermus thermophilus
Iwanaga, Extremophiles : life under extreme conditions 2014 (PubMed)- “...was observed in a putative operon, including genes TTHA0284, TTHA0283, and TTHA0282 involved in arginine biosynthesis. The promoter of this operon, argG, was...”
- “...were extracted from the promoter regions of TTHA0255, TTHA0284, TTHA0612, TTHA1199, and TTHA1914, which were shown to contain ArgR-binding sites by ChAP-chip...”
VFMJ11_2416 argininosuccinate synthase from Vibrio fischeri MJ11
VFMJ11_2416 argininosuccinate synthase from Aliivibrio fischeri MJ11
39% identity, 91% coverage
PHYSODRAFT_485399 hypothetical protein from Phytophthora sojae
39% identity, 86% coverage
- Insights into the adaptive response of the plant-pathogenic oomycete Phytophthora capsici to the fungicide flumorph
Pang, Scientific reports 2016 - “...the biosynthesis of amino acids and proteins including argininosuccinate lyase 31 and the hypothetical protein PHYSODRAFT_485399 30 , which are involved in arginine biosynthesis; hypothetical protein PHYSODRAFT_471713 30 and 5-methlytetrahydropteroyltriglutamate-homocysteine methyltransferease 32 , which play a role in methionine biosynthesis; and cysteine synthase, which participates in...”
- “...protein PHYSODRAFT_326460 Amino acid metabolism 348684607 Hypothetical protein PHYSODRAFT_344705 Amino acid metabolism 348684064 Hypothetical protein PHYSODRAFT_485399 Amino acid metabolism 348683248 hypothetical protein PHYSODRAFT_349622 Amino acid metabolism 348683007 hypothetical protein PHYSODRAFT_284659 Amino acid metabolism 348675955 hypothetical protein PHYSODRAFT_354820 Amino acid metabolism 348675840 Hypothetical protein PHYSODRAFT_260724 Amino acid...”
VP2757 argininosuccinate synthase from Vibrio parahaemolyticus RIMD 2210633
39% identity, 93% coverage
- Transcriptome analysis of Vibrio parahaemolyticus in type III secretion system 1 inducing conditions
Nydam, Frontiers in cellular and infection microbiology 2014 - “...2.1 3.1 5.2 10.5 vp2756 Bifunctional argininosuccinate lyase/N-acetylglutamate synthase COG0165E 7.5 13.1 14.4 23.4 24.6 vp2757 Argininosuccinate synthase COG0137E 12.4 29.2 33.1 52.5 65.4 vp2758 Acetylglutamate kinase COG0548E 9.5 21.3 22.6 43.7 45.7 vp2910 Hypothetical protein COG4974L 2.0 4.8 6.7 11.6 15.1 vpa0035 Sodium/glutamate symporter COG0786E...”
- “...), N-acetylglutamate synthase ( vp2371 ), arginosuccinate lyase/N-acetylglutamate synthase ( vp2756 ), arginosuccinate synthase ( vp2757 ), and acetylglutamate kinase ( vp2758 ) (Xu et al., 2006 ). A gene encoding arginine transporter permease subunit ArtM ( vpa0639 ) was also upregulated, and has been shown...”
RL4515 putative argininosuccinate synthase from Rhizobium leguminosarum bv. viciae 3841
38% identity, 92% coverage
BAU10_13660 argininosuccinate synthase from Vibrio alginolyticus
39% identity, 93% coverage
BAB1_0071 Argininosuccinate synthase from Brucella melitensis biovar Abortus 2308
37% identity, 91% coverage
LHK_02172 AssY from Laribacter hongkongensis HLHK9
38% identity, 92% coverage
- General metabolism of Laribacter hongkongensis: a genome-wide analysis
Curreem, Cell & bioscience 2011 - “...intermediates enter Serine L-serine dehydratase LHK_02265 Pyruvate, ammonia TCA cycle or gluconeogenesis Aspartate Argininosuccinate synthase LHK_02172 Fumarate, oxaloacetate, ammonia, ATP TCA cycle Argininosuccinate lyase LHK_03122 L-aspartate oxidase LHK_00001 Aspartate aminotransferase LHK_01340 Glutamine Glutamine synthetase LHK_01876 -ketoglutarate, ammonia TCA cycle Glutamate dehydrogenase LHK_01886 Glycine Glycine cleavage system...”
7k5zA / Q5ZY78 Crystal structure of argininosuccinate synthase from legionella pneumophila philadelphia 1 in complex with anppnp and a substrate analogue arginine
39% identity, 89% coverage
- Ligands: phosphoaminophosphonic acid-adenylate ester; arginine (7k5zA)
Q92L73 Argininosuccinate synthase from Rhizobium meliloti (strain 1021)
SMc03826 argininosuccinate synthase from Sinorhizobium meliloti 1021
37% identity, 91% coverage
Gasu_30780 argininosuccinate synthase from Galdieria sulphuraria
38% identity, 93% coverage
ARG1 argininosuccinate synthase; EC 6.3.4.5 from Candida albicans (see paper)
40% identity, 80% coverage
- CharProtDB CGD description: Similar to argininosuccinate synthase; enzyme of arginine biosynthesis; increased transcription is observed upon benomyl treatment; regulated by Gcn4p, Rim101p; induced in response to amino acid starvation (3-aminotriazole treatment)
1j1zA / P59846 Crystal structure of thermus thermophilus hb8 argininosuccinate synthetase in complex with substrate (see paper)
40% identity, 91% coverage
- Ligands: adenosine-5'-triphosphate; citrulline; aspartic acid (1j1zA)
VC2642 argininosuccinate synthase from Vibrio cholerae O1 biovar eltor str. N16961
39% identity, 91% coverage
- Cross-Platform Transcriptomic Data Integration, Profiling, and Mining in Vibrio cholerae
Qin, Microbiology spectrum 2023 - “...most significantly downregulated at the overall transcriptome level were vc0488 , vc0063 , vc1704 , vc2642 , and vc0386 . vc0488 is annotated as TRAP transporter substrate-binding protein, and its function has not been reported. vc0063 is annotated as thiazole biosynthesis adenylyltransferase ThiF, which belongs to...”
- “...metR gene in E. coli and activates the methionine synthesis pathway together with metH . vc2642 is annotated as argininosuccinate synthase and is involved in the aspartate and citrulline metabolic cycle. vc0386 , annotated as phosphoadenylyl-sulfate reductase, appears to be involved in the regulation of bacterial...”
- Pyomelanin produced by Vibrio cholerae confers resistance to predation by Acanthamoeba castellanii
Noorian, FEMS microbiology ecology 2017 - “...trpA (tryptophan biosynthesis), gltD and VC2373 (glutamate biosynthesis), glnA (glutamine biosynthesis) argC , VC2617, VC2641, VC2642, VC2643, and VC2508 (arginine metabolism and biosynthesis), VC1704 (cysteine and methionine metabolism), VC0162, VC0031 and VC0028 (isoleucine biosynthesis) and VC0392, VCA0604 and VCA0605 (aminotransferases). The increase in metabolism and energy...”
PMI3239 argininosuccinate synthase from Proteus mirabilis HI4320
38% identity, 93% coverage
Q2Z0F6 argininosuccinate synthase (EC 6.3.4.5) from Agaricus bisporus (see paper)
39% identity, 89% coverage
plu4742 argininosuccinate synthase (citrulline-aspartate ligase) from Photorhabdus luminescens subsp. laumondii TTO1
38% identity, 91% coverage
A4X2R7 Argininosuccinate synthase from Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / JCM 13857 / NBRC 105044 / CNB-440)
39% identity, 91% coverage
EAMY_0145 Argininosuccinate synthase from Erwinia amylovora CFBP1430
38% identity, 91% coverage
argG / CAB95023.1 argininosuccinate synthetase from Moritella abyssi (see paper)
38% identity, 93% coverage
AT4G24830 arginosuccinate synthase family from Arabidopsis thaliana
B3H778 argininosuccinate synthase from Arabidopsis thaliana
39% identity, 85% coverage
- Comparative Proteomic and Metabonomic Profiling of Buds with Different Flowering Capabilities Reveal Novel Regulatory Mechanisms of Flowering in Apple
Wang, Plants (Basel, Switzerland) 2023 - “...(R)-mandelonitrile lyase 3 63.5 27.6 12 59.7 8.03 0.59 * 0.59 * 0.99 26 MD08G1219100 At4g24830 Argininosuccinate synthase 7.5 6.9 1 53.3 5.97 1.13 0.86 1.3 * 27 MD17G1264900 ASP1 Aspartate aminotransferase 8.1 9.5 2 46.9 7.37 0.69 * 0.77 * 0.9 28 MD10G1254300 CAAT1 Cationic...”
- Changes in annual transcriptome dynamics of a clone of Japanese cedar (Cryptomeria japonica D. Don) planted under different climate conditions
Nose, PloS one 2023 - “...synthase temp-0h 0.71 CUST_10056_PI429951308 reCj24708:----:isotig24560 AT3G12780 2.1E-50 PGK1 phosphoglycerate kinase 1 temp-60d 0.73 CUST_1587_PI429951308 reCj13430:----:isotig13285 AT4G24830 0.0 - arginosuccinate synthase family temp-0h 0.75 CUST_1081_PI429951308 reCj11634:MSWR:isotig11489 AT3G03780 0.0 MS2 methionine synthase 2 temp-0h 0.77 CUST_4912_PI429951308 reCj19509:MSWR:isotig19361 AT3G48560 0.0 CSR1 chlorsulfuron/imidazolinone resistant 1 temp-30d 0.85 CUST_8310_PI429951308 reCj22939:MSWR:isotig22791 AT2G36460...”
- New Insight into Aspartate Metabolic Pathways in Populus: Linking the Root Responsive Isoenzymes with Amino Acid Biosynthesis during Incompatible Interactions of Fusarium solani
Han, International journal of molecular sciences 2022 - “...poorly known in plants. The recent work demonstrated in Arabidopsis revealed that a single gene (At4G24830) encoded ASS was characterized in correlation to Arg cycling, but there were no visible effects on growth [ 89 ]. A genome-wide association study identified ASS as accounting for 7%...”
- Molecular mechanisms of resistance to Myzus persicae conferred by the peach Rm2 gene: A multi-omics view
Le, Frontiers in plant science 2022 - “...carbamoyltransferase Prupe_6G250400 AT2G37500 75 Yes -1.4 5.30E-03 ArgJ; Arginine biosynthesis bifunctional protein ArgJ, chloroplastic Prupe_5G153100 AT4G24830 79 Yes -2.9 5.90E-19 ASSY; Arginosuccinate synthase Prupe_3G092300 AT4G08900 30 No 2.2 8.70E-04 ARGAH1; Arginase 1 Prupe_2G076400 AT4G08870 68 No 6.8 3.50E-06 ARGAH2; Arginase 2 Prupe_5G019100 AT5G45380 79 Yes 2.0...”
- Gel-based proteomic map of Arabidopsis thaliana root plastids and mitochondria
Grabsztunowicz, BMC plant biology 2020 - “...kinase 92 Q9SCL7, At3g57560 Acetylornithine aminotransferase 62, 63 Q9M8M7, At1g80600 Argininosuccinate synthase 51, 52 Q9SZX3, At4g24830 ATP phosphoribosyltransferase 1 62 Q9S762, At1g58080 Bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase 30 Q9SQT8, At3g06350 Bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase 64, 66 Q9SIE1, At2g22250 Branched-chain-amino-acid aminotransferase 3 64, 66 Q9M401, At3g49680...”
- “...further used by ornithine transcarbamomylase (OTC, At1g75330, spot 85) to form citrulline. Argininosuccinate synthase (AS, At4g24830) detected in spot 51 and 52 converts L-citrulline to argininosuccinate that is the direct substrate for synthesis of L-arginine [ 25 ]. The branched-chain amino acids (BCAAs), namely L-isoleucine, L-valine...”
- Dual lysine and N-terminal acetyltransferases reveal the complexity underpinning protein acetylation
Bienvenut, Molecular systems biology 2020 - “...were affected in their NTA yield. The six major target proteins corresponded to AT2G24820 (TIC55), AT4G24830 (ASSY), AT3G54050 (F16P1), AT1G16080 (unknown protein), AT4G27440 (PORB), and AT1G03630 (PORC; Table 2 and Dataset EV4 ). Figure 5 Inactivation of GNAT 2 (NSI) unveils dual KA and NTA activity...”
- “...0.05 1.08 + 6 AT4G34290 Plastid Q9SYZ4 50 (Nt) 0.09 n.i . n.i . 7 AT4G24830 Plastid ASSY 75 (Nt) 0.31 n.i . + 8 AT3G54050 Plastid F16P1 61 (Nt); 323 (K) 0.32 0.97 + 1* AT1G01790 Plastid KEA1 168 (K) n.i . 0.02 + 2*...”
- A proteomic analysis of peanut seed at different stages of underground development to understand the changes of seed proteins
Li, PloS one 2020 - “...identified, including glutamine synthetase (GS2, XP_016197383.1), S-adenosylmethionine synthetase (SAM-2, XP_016205701.1 and MTO3, XP_015945019.1), argininosuccinate synthase (AT4G24830, XP_015961120.1) and 2-isopropylmalate synthase (IMS1, XP_020966519.1). 10.1371/journal.pone.0243132.g005 Fig 5 Protein-protein interaction networks of identified proteins. (Green and red indicate high expression at the early stage and late stage, respectively). Analysis...”
- Low CO2 induces urea cycle intermediate accumulation in Arabidopsis thaliana
Blume, PloS one 2019 - “...CAACAATGTGGCGGCTTCTCTC CGATGCCTGCTCAGTTGCAAG ArgAH1 AT4G08900 CGGCATTTGCACCTGGAGTGT TGCGGGTTGAACTCGACAACG ArgAH2 AT4G08870 CCTTGCGGTCCTTGCCAACTTC GCTGTTGTAGCTTTTGCTCCTCCTATG ASL AT5G10920 GCAGGACATCTTGATGCGACTACTC CCTTTTGAGACGCAAACTCCAACTAG ASSY AT4G24830 GGAAAAGGAAATGACCAGGTTCGG TCAATAGCATCTTCTCGGCCTTGG CARA AT3G27740 TGCACGAAGACACTTGCTGA CTGTGCTCAACACCCCGATA CLPD AT5G51070 CCGTCCAGAGTTGTTGAACCG CCACGAGCCTCGACTTCAAGTC DIN4 AT3G13450 GACACTCCTTTCCCTCTAGTGTTCG ATTCACAGTGGATCTGATTGCATCC dOAT AT5G46180 TGTCCCCGGTTTCAGCTTAC AGCCTCAGATCCATCTCGGA IMD AT5G14200/AT1G31180 CGATGCTTCTCAAGTATGGACTTGG CCATTTCCTTGCATCCCACCAG NAGS2 AT4G37670 GAAGGAACCCGTGATGCCAGAG GCTCGCAGTAACTCCTCATCAGTTC OTC AT1G75330 CAAAGGCAAAGCAAGCTGGA CGGCTTCATCCTTTTGACCC...”
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- Protein Profiling of Arabidopsis Roots Treated With Humic Substances: Insights Into the Metabolic and Interactome Networks
Roomi, Frontiers in plant science 2018 - “...Expressed protein 1.5 68.9 9 CH Q96522 AT4G30170 Peroxidase 45 1.5 71.1 17 EC, EM B3H778 AT4G24830 Argininosuccinate synthase 1.5 8.4 3 CH P42760 AT1G02930 Glutathione- S -transferase F6 1.5 52.9 6 CW, M, V, Q43725 AT3G59760 Cysteine synthase, mitochondrial 1.6 17.4 4 M, CH Q42338...”
Q4WHT0 argininosuccinate synthase from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293)
AFUA_2G04310 argininosuccinate synthase from Aspergillus fumigatus Af293
41% identity, 86% coverage
G4MTK2 argininosuccinate synthase from Pyricularia oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
38% identity, 96% coverage
- Evaluating Eucalyptus leaf colonization by Brasilonema octagenarum (Cyanobacteria, Scytonemataceae) using in planta experiments and genomics.
Alvarenga, PeerJ 2020 - “...IPMDH 3-isopropylmalate dehydrogenase + + + + + G4ML75 MET6 methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase + + + G4MTK2 MoARG1 arginine biosynthesis + + + + + G4MXC5 MoPRX1 peroxiredoxin peroxidase + + + + + G4N4N6 MoSFA1 S-(hydroxymethyl)glutathione dehydrogenase + + + + + G4NCL5 MGG_00383 hypothetical protein...”
- “...genomes and proteins deposited in PHI-base ( C5A9K4 , D4I307 , F5HCK8 , G4ML75 , G4MTK2 , Q4UTV7 , Q4UUL4 , Q8XSV8 , Q8Y0J2 and Q9C1T0 ) are likely to indicate enzymes with roles in primary metabolism ( Cooley et al., 1999 ; Namiki et al.,...”
CNAG_00930 argininosuccinate synthase from Cryptococcus neoformans var. grubii H99
40% identity, 88% coverage
CC0129 argininosuccinate synthase from Caulobacter crescentus CB15
37% identity, 92% coverage
S4V5K7 argininosuccinate synthase (EC 6.3.4.5) from Protopterus annectens (see paper)
36% identity, 90% coverage
TEL01S_RS01770 argininosuccinate synthase from Pseudothermotoga elfii DSM 9442 = NBRC 107921
35% identity, 92% coverage
- Adaptation Strategies to High Hydrostatic Pressures in Pseudothermotoga species Revealed by Transcriptional Analyses
Fenouil, Microorganisms 2023 - “...They include genes with locus tags TEL01S_RS00940 to TEL01S_RS00950, which encode a peptide/nickel transport system; TEL01S_RS01770 to TEL01S_RS01785, which are genes linked to the arginine biosynthesis pathway; TEL01S_RS03985 to TEL01S_RS03995, which encode a branched-chain amino acid transport system; TEL01S_RS03635, which encodes an aspartate kinase LysC; and...”
- “...* TEL01S_RS01780 argC ko00220:Arginine biosynthesis 0 1 1 TEL01S_RS01785 argJ ko00220:Arginine biosynthesis 0 1 1 TEL01S_RS01770 argG ko00220:Arginine biosynthesis|ko00250:Alanine, aspartate, and glutamate metabolism 0 1 1 TEL01S_RS01775 argH ko00220:Arginine biosynthesis|ko00250:Alanine, aspartate, and glutamate metabolism 0 1 1 TEL01S_RS04500 glnA ko00220:Arginine biosynthesis|ko00250:Alanine, aspartate, and glutamate metabolism 0...”
MUW98_RS20405 argininosuccinate synthase from Aeromonas hydrophila
37% identity, 92% coverage
Q6FWJ8 argininosuccinate synthase from Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)
38% identity, 92% coverage
ASSY_SCHPO / O94354 Argininosuccinate synthase; Citrulline--aspartate ligase; EC 6.3.4.5 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see 2 papers)
arg12 / RF|NP_595183.1 argininosuccinate synthase (predicted); EC 6.3.4.5 from Schizosaccharomyces pombe (see 2 papers)
SPBC428.05c argininosuccinate synthase (predicted) from Schizosaccharomyces pombe
40% identity, 87% coverage
An15g02340 uncharacterized protein from Aspergillus niger
38% identity, 91% coverage
B5Y3V3 argininosuccinate synthase from Phaeodactylum tricornutum (strain CCAP 1055/1)
36% identity, 89% coverage
AO090023000395 No description from Aspergillus oryzae RIB40
39% identity, 82% coverage
M7WMY0 argininosuccinate synthase from Rhodotorula toruloides (strain NP11)
37% identity, 91% coverage
NP_001004603 argininosuccinate synthase from Danio rerio
Q66I24 Argininosuccinate synthase from Danio rerio
35% identity, 96% coverage
- ASS1 deficiency is associated with impaired neuronal differentiation in zebrafish larvae.
Seidl, Molecular genetics and metabolism 2024 (PubMed)- GeneRIF: ASS1 deficiency is associated with impaired neuronal differentiation in zebrafish larvae.
- Dietary Creatine Supplementation in Gilthead Seabream (Sparus aurata): Comparative Proteomics Analysis on Fish Allergens, Muscle Quality, and Liver
Schrama, Frontiers in physiology 2018 - “...bruneus )] 12,510 15,857/9,797 5.03/4.8 9 48 0.006 0.0137 2.19 CTRL>CR8> CR2>CR5 Metabolic pathway 623 Q66I24 Argininosuccinate synthase OS Danio rerio 504 47,099/46,671 6.46/5.5 5 7 0.01 0.0112 1.32 CR5>CR2> CR8>CTRL 1,013 Q1MTI4 Triosephosphate isomerase A OS Danio rerio 2,170 26,836/26,776 4.72/4.7 6 25 0.002 0.0023...”
ASSY_RAT / P09034 Argininosuccinate synthase; Citrulline--aspartate ligase; EC 6.3.4.5 from Rattus norvegicus (Rat) (see paper)
XP_006233973 argininosuccinate synthase isoform X1 from Rattus norvegicus
36% identity, 93% coverage
- function: One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals (Probable). Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues (Probable). Indirectly, may be involved in the control of blood pressure (PubMed:19491403).
catalytic activity: L-citrulline + L-aspartate + ATP = 2-(N(omega)-L- arginino)succinate + AMP + diphosphate + H(+) (RHEA:10932)
subunit: Homotetramer. Interacts with NMRAL1. Interacts with CLOCK; in a circadian manner (By similarity). Forms tissue-specific complexes with ASL, SLC7A1, HSP90AA1 and nitric oxide synthase NOS1, NOS2 or NOS3; the complex regulates cell-autonomous L-arginine synthesis and citrulline recycling while channeling extracellular L-arginine to nitric oxide synthesis pathway (By similarity). - The Multienzyme Complex Nature of Dehydroepiandrosterone Sulfate Biosynthesis.
Tumilovich, International journal of molecular sciences 2024 - “...Sulfotransferase 1C1 P50237 3 18.4 Cyb5a Cytochrome b5, microsomal P00173 2 23.9 Ass1 Argininosuccinate synthase P09034 2 4.9 Aldob Fructose-bisphosphate aldolase B P00884 1 5.5 Rab7a Ras-related protein Rab-7a P09527 1 6.8 Cyp2d10 * Cytochrome P450 2D10 P12939 1 2.2 Cyp2d1 * Cytochrome P450 2D1 P10633...”
- Investigation into potential mechanisms of metabolic syndrome by integrative analysis of metabolomics and proteomics.
Chen, PloS one 2022 - “...oxidase 3 Oxidoreductase 1.253 0.0003 Asns P49088 Asparagine synthetase [glutamine-hydrolyzing] Amino-acid biosynthesis 0.597 0.0245 Ass1 P09034 Argininosuccinate synthase Amino-acid biosynthesis 1.378 0.0006 Bhmt O09171 Betainehomocysteine S-methyltransferase 1 Homocysteine metabolism. 1.314 0.0039 Cps1 P07756 Carbamoyl-phosphate synthase [ammonia] Urea cycle 1.29 0.0003 Cth P18757 Cystathionine gamma-lyase Cysteine biosynthesis...”
- Melatonin in preservation solutions prevents ischemic injury in rat kidneys.
Coskun, PloS one 2022 - “...Transketolase TKT_RAT Tkt P50137 Adenosine monophosphate-protein transferase FICD FICD_RAT Ficd Q6AY47 Argininosuccinate synthase ASSY_RAT Ass1 P09034 Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 ALKB3_RAT Alkbh3 Q5XIC8 Alcohol dehydrogenase [NADP(+)] AK1A1_RAT Akr1a1 P51635 Porphobilinogen deaminase HEM3_RAT Hmbs P19356 Isoaspartyl peptidase/L-asparaginase ASGL1_RAT Asrgl1 Q8VI04 Protein THEM6 THEM6_RAT Them6 Q5XIE1 Ras-related...”
- Integrative proteomics and metabolomics of Guizhou Miao Sour Soup affecting simple obese rats.
Yuan, Frontiers in nutrition 2022 - “...Got1 Down 0.672 0.0005016 Up 1.652 0.0044859 P12785 Fasn Down 0.531 0.0036612 Up 2.195 0.00184 P09034 Ass1 Down 0.686 0.0007396 Up 1.41 0.003824 Q499N5 Acsf2 Down 0.384 0.0127379 Up 2.508 0.0085134 P11497 Acaca Down 0.741 0.007918 Up 1.5 0.0033102 Q4KLP0 Dhtkd1 Down 0.519 2.454E-05 Up 1.786...”
- Modulation of the Liver Protein Carbonylome by the Combined Effect of Marine Omega-3 PUFAs and Grape Polyphenols Supplementation in Rats Fed an Obesogenic High Fat and High Sucrose Diet
Méndez, Marine drugs 2019 - “...Endoplasmic reticulum 45,112 45 24 (24) Q03248 Beta-ureidopropionase Upb1 Cytoplasm 44,042 28 12 (12) 13 P09034 Argininosuccinate synthase Ass1 Cytosol 46,496 54 48 (48) 14 P16617 Phosphoglycerate kinase 1 Pgk1 Cytoplasm 44,538 20 7 (7) P13437 3-ketoacyl-CoA thiolase mitochondrial Acaa2 Mitochondria 41,871 41 19 (19) 15...”
- Effects of Iron Oxide Nanoparticles (γ-Fe2O3) on Liver, Lung and Brain Proteomes following Sub-Acute Intranasal Exposure: A New Toxicological Assessment in Rat Model Using iTRAQ-Based Quantitative Proteomics.
Askri, International journal of molecular sciences 2019 - “...P04797 Glyceraldehyde-3-phosphate dehydrogenase P61206 ADP-ribosylation factor 3 D3ZFQ8 Cytochrome c-1 Arginine biosynthesis (P02728) 1 1.5% P09034 Argininosuccinate synthase Glycolysis (P00024) 2 3.1% P04797 Glyceraldehyde-3-phosphate dehydrogenase P12928 Pyruvate kinase Parkinson disease (P00049) 1 1.5% P63102 14-3-3 protein zeta/delta Plasminogen activating cascade (P00050) 1 1.5% P02680 Fibrinogen gamma...”
- Quantitative proteomic analysis of intracerebral hemorrhage in rats with a focus on brain energy metabolism.
Liu, Brain and behavior 2018 - “...55.38 26 Ca2 Carbonic anhydrase 2 1.32 D4A133 65.3 69.21 87 Atp6v1a Protein Atp6v1a 0.55 P09034 13.4 23.30 9 Ass1 Argininosuccinate synthase 0.59 P04177 10.48 12.45 7 Th Tyrosine 3monooxygenase 0.65 B5DEN4 34.63 64.46 37 RGD1562690 Llactate dehydrogenase 0.66 Q5XIH3 35.39 58.84 31 Ndufv1 NADH dehydrogenase...”
- Functional proteomic analysis of corticosteroid pharmacodynamics in rat liver: Relationship to hepatic stress, signaling, energy regulation, and drug metabolism.
Ayyar, Journal of proteomics 2017 - “...Recognition signal for the binding and internalization of LDL particles by the apoB/E receptor DOWN P09034 Ass1 Argininosuccinate synthase Blood pressure regulation; catalyzes the penultimate step of the arginine biosynthetic pathway UP P14173 Ddc Aromatic-L-amino-acid decarboxylase Decarboxylation of L-DOPA to dopamine, and L-5-hydroxytryptophan to serotonin UP...”
- More
- Argininosuccinate synthetase regulates hepatic AMPK linking protein catabolism and ureagenesis to hepatic lipid metabolism.
Madiraju, Proceedings of the National Academy of Sciences of the United States of America 2016 - GeneRIF: these studies demonstrate that increased amino acid flux can activate AMPK through increased AMP generated by ASS, thus providing a novel link between protein catabolism, ureagenesis, and hepatic lipid metabolism.
- Transient ischemia increases neuronal nitric oxide synthase, argininosuccinate synthetase and argininosuccinate lyase co-expression in rat striatal neurons.
Bizzoco, Experimental neurology 2007 (PubMed)- GeneRIF: 24 h after reperfusion, number of nNOS-positive neurons and tpercentage of those co-expressing ASS and ASL were significantly increased in the animals with a longer survival. 144 h after ischemia there was almost complete restore of these neurons.
- Activated microglia cells express argininosuccinate synthetase and argininosuccinate lyase in the rat brain after transient ischemia.
Bizzoco, Experimental neurology 2007 (PubMed)- GeneRIF: Local factors such as the NO produced by nNOS/ASS/ASL-positive neurons, could influence ASS/ASL-positive microglia cells avoiding or allowing the induction, in these cells, of iNOS.
- Effect of chronic renal failure on arginase and argininosuccinate synthetase expression.
Moradi, American journal of nephrology 2006 (PubMed)- GeneRIF: The latter, in turn, attenuates L-arg catabolism and urea production and, thereby, mitigates the fall in plasma L-arg.
- Argininosuccinate synthetase is reversibly inactivated by S-nitrosylation in vitro and in vivo.
Hao, The Journal of biological chemistry 2004 (PubMed)- GeneRIF: Argininosuccinate synthetase has a role in preventing autotoxicity from nitric oxide overproduction
ASSY_BOVIN / P14568 Argininosuccinate synthase; Citrulline--aspartate ligase; EC 6.3.4.5 from Bos taurus (Bovine) (see paper)
NP_776317 argininosuccinate synthase from Bos taurus
36% identity, 93% coverage
- function: One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues.
catalytic activity: L-citrulline + L-aspartate + ATP = 2-(N(omega)-L- arginino)succinate + AMP + diphosphate + H(+) (RHEA:10932)
subunit: Homotetramer. Interacts with NMRAL1. Interacts with CLOCK; in a circadian manner (By similarity). Forms tissue-specific complexes with ASL, SLC7A1, HSP90AA1 and nitric oxide synthase NOS1, NOS2 or NOS3; the complex regulates cell-autonomous L-arginine synthesis and citrulline recycling while channeling extracellular L-arginine to nitric oxide synthesis pathway (By similarity). - Characterization of paucibacillary ileal lesions in sheep with subclinical active infection by Mycobacterium avium subsp. paratuberculosis
Pisanu, Veterinary research 2018 - “...b 2.22 1.16 a Q2TBP0 PSMB7 Proteasome subunit beta type-7 1.64 a 2.10 1.30 a P14568 ASS1 Argininosuccinate synthase 1.40 a 2.05 1.09 b Q2TBU0 HP Haptoglobin 8.14 b 13.84 P00639 DNASE1 Deoxyribonuclease-1 3.97 b 1.57 b 6.48 P30922 CHI3L1 Chitinase-3-like protein 1 3.67 b 1.16...”
- Protein kinase Cα phosphorylates a novel argininosuccinate synthase site at serine 328 during calcium-dependent stimulation of endothelial nitric-oxide synthase in vascular endothelial cells.
Haines, The Journal of biological chemistry 2012 - GeneRIF: calcium-dependent phosphorylation of argininosuccinate synthase Ser-328 is mediated by PKCalpha
- Phosphorylation of argininosuccinate synthase by protein kinase A.
Corbin, Biochemical and biophysical research communications 2008 (PubMed)- GeneRIF: These results represent the first demonstration that vascular endothelial nitric oxide production can be regulated by dynamic argininosuccinate synthase phosphorylation.
- Tumor necrosis factor-alpha reduces argininosuccinate synthase expression and nitric oxide production in aortic endothelial cells.
Goodwin, American journal of physiology. Heart and circulatory physiology 2007 (PubMed)- GeneRIF: In endothelial cells TNF-alpha coordinately downregulates nitric oxide synthase (eNOS) and argininosuccinate synthase expression, resulting in a severely impaired citrulline-NO cycle.
- Regulation of endothelial argininosuccinate synthase expression and NO production by an upstream open reading frame.
Pendleton, The Journal of biological chemistry 2005 (PubMed)- GeneRIF: the function of the extended 5'-UTRs of AS mRNA was investigated
- Argininosuccinate synthase expression is required to maintain nitric oxide production and cell viability in aortic endothelial cells.
Goodwin, The Journal of biological chemistry 2004 (PubMed)- GeneRIF: dose-dependent reduction of ASS as a result of siRNA treatment corresponded to diminished capacity to produce NO, despite saturating levels of arginine in the medium; reduced expression of ASS resulted in loss of viability due to apoptosis
ASSY_MOUSE / P16460 Argininosuccinate synthase; Citrulline--aspartate ligase; EC 6.3.4.5 from Mus musculus (Mouse) (see 3 papers)
P16460 argininosuccinate synthase (EC 6.3.4.5) from Mus musculus (see 4 papers)
Q3UJ34 Argininosuccinate synthase from Mus musculus
NP_031520 argininosuccinate synthase from Mus musculus
36% identity, 93% coverage
- function: One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues.
catalytic activity: L-citrulline + L-aspartate + ATP = 2-(N(omega)-L- arginino)succinate + AMP + diphosphate + H(+) (RHEA:10932)
subunit: Homotetramer. Interacts with NMRAL1 (By similarity). Interacts with CLOCK; in a circadian manner (PubMed:28985504). Forms tissue- specific complexes with ASL, SLC7A1, HSP90AA1 and nitric oxide synthase NOS1, NOS2 or NOS3; the complex regulates cell-autonomous L-arginine synthesis and citrulline recycling while channeling extracellular L- arginine to nitric oxide synthesis pathway. - Mass spectrometry-based analysis of murine bronchoalveolar lavage fluid following respiratory exposure to 4,4'-methylene diphenyl diisocyanate aerosol
Hettick, Xenobiotica; the fate of foreign compounds in biological systems 2018 - “...Accession Description MW (Da) Fold change Up/down P33267 Cytochrome P450 2F2 55 913 +4.08 Up Q3UJ34 Argininosuccinate synthase 46 555 +4.36 Up P08113 Endoplasmin 92 418 +3.22 Up Q3U7H1 Napsin A 45 515 +2.95 Up Q8CGP7 Histone H2A 14 140 +2.89 Up Q64524 Histone H2B 13...”
- “...Accession Description MW (Da) Fold change Up/Down P33267 Cytochrome P450 2F2 55 913 +4.97 Up Q3UJ34 Argininosuccinate synthase 46 555 +4.36 Up P08113 Endoplasmin 92 418 +3.07 Up Q3U7H1 Napsin A 45 515 +2.91 Up Q64524 Histone H2B 13 984 +2.51 Up Q8CGP7 Histone H2A 14...”
- Multifactorial comparative proteomic study of cytochrome P450 2E1 function in chronic alcohol administration.
Wang, PloS one 2014 - “...Aass oxidation reduction 2.01 - Q7TSZ0 Heat shock protein 9 Hspa9 * chaperone 2.01 - Q3UJ34 Argininosuccinate synthase Ass1 ** oxidation reduction 1.95 - Q3UKT3 Putative uncharacterized protein Oat amino acid metabolism 1.87 - Q544B1 Aldehyde dehydrogenase 2 Aldh2 * alcohol metabolism 1.79 - Q546G4 Albumin...”
- Citrulline depletion by ASS1 is required for proinflammatory macrophage activation and immune responses.
Mao, Molecular cell 2022 (PubMed)- GeneRIF: Citrulline depletion by ASS1 is required for proinflammatory macrophage activation and immune responses.
- Epithelial argininosuccinate synthetase is dispensable for intestinal regeneration and tumorigenesis.
van, Cell death & disease 2021 - GeneRIF: Epithelial argininosuccinate synthetase is dispensable for intestinal regeneration and tumorigenesis.
- Argininosuccinate synthase 1 is an intrinsic Akt repressor transactivated by p53.
Miyamoto, Science advances 2017 - GeneRIF: findings uncover a new function of p53 in the regulation of Akt signaling and reveal how p53, ASS1, and Akt are interrelated to each other.
- CLOCK Acetylates ASS1 to Drive Circadian Rhythm of Ureagenesis.
Lin, Molecular cell 2017 (PubMed)- GeneRIF: ASS1 acetylation by CLOCK exhibits circadian oscillation in human cells and mouse liver, possibly caused by rhythmic interaction between CLOCK and ASS1, leading to the circadian regulation of ASS1 and ureagenesis.
- Ethanol plus the Jo2 Fas agonistic antibody-induced liver injury is attenuated in mice with partial ablation of argininosuccinate synthase.
Lu, Alcoholism, clinical and experimental research 2014 - GeneRIF: may contribute to liver injury by enhancing nitrosative stress
- Cyclic adenosine monophosphate-induced argininosuccinate synthase 1 expression is essential during mouse decidualization.
Huang, Molecular and cellular endocrinology 2014 (PubMed)- GeneRIF: cAMP-induced Ass1 expression is important in controlling the magnitude of decidualization through regulating L-Arg level.
- A transgenic approach to study argininosuccinate synthetase gene expression.
Shiue, Journal of biomedical science 2014 - GeneRIF: We demonstrate that the transgenic mouse system reported here has the merit of sensitivity and direct visualization advantage, and is ideal for annotating temporal and spatial expression profiles and the regulation mode of the ASS gene.
- Endothelial arginine resynthesis contributes to the maintenance of vasomotor function in male diabetic mice.
Chennupati, PloS one 2014 - GeneRIF: In diabetic mice, ablation of Ass resulted in diminished endothelium-derived nitric oxide-mediated vascular relaxation responses.
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- A Murine Model of Maternal Micronutrient Deficiencies and Gut Inflammatory Host-microbe Interactions in the Offspring.
Holani, Cellular and molecular gastroenterology and hepatology 2024 - “...2.94283621103085E-05 0.04543739109831640 Down-regulated P14824 Anxa6 0.601833921491811 1.46513193834636E-05 0.022973268793271000 Down-regulated P16110 Lgals3 0.8671999751166040 1.57784847876247E-05 0.02470910717742030 Up-regulated P16460 Ass1 1.273999972640000 2.8363554950416E-05 0.043821692398392800 Down-regulated P16858 Gapdh;Gm3839 0.49179961132435600 9.34289493363338E-06 0.014761773995140700 Up-regulated P17182 Eno1 0.4141117279066980 1.57279240854768E-05 0.024645657041942100 Up-regulated P17751 Tpi1 0.4769660851008110 1.0744454679598E-05 0.016944005029726100 Up-regulated P19324 Serpinh1 0.8716923425011680 1.47080155918761E-06 0.0023473992884634200 Down-regulated P22437...”
- Proteomic Analysis of Protective Effects of Dl-3-n-Butylphthalide against mpp + -Induced Toxicity via downregulating P53 pathway in N2A Cells
Zhao, Proteome science 2023 - “...of Lysosome-associated membrane glycoprotein 2 0.005181 P16546 Sptan1 \Spectrin alpha chain, non-erythrocytic 1 \"" 0.00011 P16460 Ass1 Argininosuccinate synthase 2.21E-06 P16110 Lgals3 Galectin-3 5.90E-05 P14901 Hmox1 Heme oxygenase 1 0.001048 P14873 Map1b Microtubule-associated protein 1B 3.11E-05 P14824 Anxa6 Annexin A6 0.000366 P13020 Gsn Gelsolin 0.00029 P11928...”
- Multi-omics reveals aging-related pathway in natural aging mouse liver.
Tang, Heliyon 2023 - “...(STY)]LIVEK_ (S488) 0.298876544065367 0.0271400442638472 A0A6I9LDE6 Hnrnpk HNRPK_MOUSE _DYDDMS[Phospho (STY)]PR_ (S283); (S259); (S260); (S284); 0.202655506175861 0.000274312680619401 P16460 Ass1 ASSY_MOUSE _QHGIPIPVT[Phospho (STY)]PK_ (T174) 1.58933648245381 0.007293343641764 P16460 Ass1 ASSY_MOUSE _Q[Gln->pyro-Glu]HGIPIPVT[Phospho (STY)]PK_ (T174) 0.527255982404853 0.0143278981421657 P16460 Ass1 ASSY_MOUSE _APNS[Phospho (STY)]PDVLEIEFK_ (S219) 0.409737640889429 0.000894758857725513 Fig. 7 Display pathways and PPI diagrams...”
- TMT-Based Quantitative Proteomic Analysis Reveals the Effect of Bone Marrow Derived Mesenchymal Stem Cell on Hair Follicle Regeneration
Zhang, Frontiers in pharmacology 2021 - “...Cntfr 2.207 1.66E-02 2.102 1.54E-02 Q9JMG1 Endothelial differentiation-related factor 1 Edf1 2.16 1.18E-02 1.908 2.87E-02 P16460 Argininosuccinate synthase Ass1 2.114 2.85E-03 1.958 9.77E-03 E9PVX6 Proliferation marker protein Ki-67 Mki67 2.091 3.10E-03 2.005 4.46E-03 C0HKG6 Ribonuclease T2-B Rnaset2b 2.081 3.82E-03 1.975 3.23E-02 Q02614 SAP30-binding protein Sap30bp 2.076...”
- Diminazene Aceturate Stabilizes Atherosclerotic Plaque and Attenuates Hepatic Steatosis in apoE-Knockout Mice by Influencing Macrophages Polarization and Taurine Biosynthesis.
Stachowicz, International journal of molecular sciences 2021 - “...2 1.16 Q91X83 Mat1a S-adenosylmethionine synthase isoform type-1 1.17 P05201 Got1 Aspartate aminotransferase, cytoplasmic 1.20 P16460 Ass1 Argininosuccinate synthase 1.22 P29758 Oat Ornithine aminotransferase, mitochondrial 1.25...”
- Diabetes Induced Alterations in Murine Vitreous Proteome Are Mitigated by IL-6 Trans-Signaling Inhibition.
Robinson, Investigative ophthalmology & visual science 2020 - “...18.59 0.0027 1.00 1.0000 P16546 Sptan1 Spectrin alpha chain, nonerythrocytic 1 18.20 0.0027 11.67 0.1065 P16460 Ass1 Argininosuccinate synthase 17.52 0.0027 15.24 0.0443 Q78ZA7 Nap1l4 Nucleosome assembly protein 1like 4 17.43 0.0027 13.73 0.0767 O35945 Aldh1a7 Aldehyde dehydrogenase, cytosolic 1 16.92 0.0050 1.00 1.0000 P01027 C3...”
- MS/MS in silico subtraction-based proteomic profiling as an approach to facilitate disease gene discovery: application to lens development and cataract.
Aryal, Human genetics 2020 - “...1-like 4 None found 68 Rpl13 P47963 60S ribosomal protein L13 None found 69 Ass1 P16460 Argininosuccinate synthase None found 70 Tpm3 P21107 Tropomyosin alpha-3 chain None found 71 Bpnt1 Q9Z0S1 3(2),5-bisphosphate nucleotidase 1 None found 72 Sumo2 P61957 Small ubiquitin-related modifier 2 (SUMO-2) None found...”
- Proteomic analysis of AQP11-null kidney: Proximal tubular type polycystic kidney disease.
Saito, Biochemistry and biophysics reports 2018 - “...0.48 0.54 0.17 0.42 0.09 Q9D964 Glycine amidinotransferase, mitochondrial Gatm 0.48 0.62 0.13 0.34 0.06 P16460 Argininosuccinate synthase Ass1 0.48 0.60 0.14 0.36 0.06 Q8BWT1 3-ketoacyl-CoA thiolase, mitochondrial Acaa2 0.49 0.57 0.13 0.42 0.07 O88338 Cadherin-16 Cdh16 0.50 0.55 0.12 0.46 0.07 These proteins were functionally...”
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XP_003353734 argininosuccinate synthase from Sus scrofa
36% identity, 93% coverage
ASS1 / P00966 Argininosuccinate synthase (EC 6.3.4.5) from Homo sapiens (see 7 papers)
ASSY_HUMAN / P00966 Argininosuccinate synthase; Citrulline--aspartate ligase; EC 6.3.4.5 from Homo sapiens (Human) (see 21 papers)
P00966 argininosuccinate synthase (EC 6.3.4.5) from Homo sapiens (see 9 papers)
NP_000041 argininosuccinate synthase from Homo sapiens
36% identity, 93% coverage
- function: One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues.
catalytic activity: L-citrulline + L-aspartate + ATP = 2-(N(omega)-L- arginino)succinate + AMP + diphosphate + H(+) (RHEA:10932)
subunit: Homotetramer (PubMed:18323623). Interacts with NMRAL1 (PubMed:17496144). Interacts with CLOCK; in a circadian manner (PubMed:28985504). Forms tissue-specific complexes with ASL, SLC7A1, HSP90AA1 and nitric oxide synthase NOS1, NOS2 or NOS3; the complex regulates cell-autonomous L-arginine synthesis and citrulline recycling while channeling extracellular L-arginine to nitric oxide synthesis pathway. - Proteomic Analysis Reveals Cadherin, Actin, and Focal Adhesion Molecule-Mediated Formation of Cervical Cancer Spheroids
Molika, Cells 2024 - “...P62081 1.674 0.044 20 SRRM2 Q9UQ35 1.569 0.026 21 VASP P50552 1.541 0.025 22 ASSY P00966 1.497 0.041 23 HS105 Q92598 1.265 0.046 24 ERF1 P62495 1.254 0.021 25 EHD2 Q9NZN4 1.225 0.050 26 GSHR P00390 1.128 0.047 27 IF4A3 P38919 1.124 0.026 28 HARS1 P12081...”
- Proteomic Profiling Identifies Candidate Diagnostic Biomarkers of Hydrosalpinx in Endometrial Fluid: A Pilot Study
Gonzalez-Martin, International journal of molecular sciences 2024 - “...shock 70 kDa protein 1B 0.014 2.33 Q08211 DHX9 ATP-dependent RNA helicase A 0.024 2.33 P00966 ASSY Argininosuccinate synthase 0.038 2.63 O14773 TPP1 Tripeptidyl-peptidase 1 0.020 2.63 O94760 DDAH1 N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 0.040 3.03 Q96TA1 NIBA2 Protein Niban 2 0.011 3.03 Q01995 TAGL Transgelin 0.010 3.13...”
- Proteomics of Serum Samples for the Exploration of the Pathological Mechanism of Obstetric Antiphospholipid Syndrome.
Zhang, Journal of proteome research 2024 - “...O00748 CES2 cocaine esterase (EC3.1.1.84) (carboxylesterase2) (CE-2) (hCE-2) (EC3.1.1.1) (methylumbelliferyl-acetate deacetylase2) (EC3.1.1.56) 12.3 2.1610 7 P00966 ASS1 argininosuccinate synthase (EC6.3.4.5) (citrulline-aspartate ligase) 1.06 2.2610 3 P13497 BMP1 bone morphogenetic protein1 (BMP-1) (EC3.4.24.19) (mammalian tolloid protein) (mTld) (procollagen C-proteinase) (PCP) 13.4 6.2710 7 O43529 CHST10 carbohydrate sulfotransferase...”
- Visualization of argininosuccinate synthetase by in silico analysis: novel insights into citrullinemia type I disorders.
Gu, Frontiers in molecular biosciences 2024 - “...of ASS1 gene 2.3.1 Protein modeling and analysis The protein sequence of ASS1 (accession number P00966) was harvested from UniProt ( https://www.uniprot.org/uniprotkb/P00966).SWISS - MODEL ( Waterhouse et al., 2018 ) and trRosetta ( Du Z et al., 2021 ) were utilized to obtain relatively accurate wild-type...”
- N-terminal proteoforms may engage in different protein complexes
Bogaert, Life science alliance 2023 - “...kinase Yes Yes AHCY P23526 Adenosylhomocysteinase Yes Yes ASNA1 O43681 ATPase ASNA1 Yes Yes ASS1 P00966 Argininosuccinate synthase Yes Yes BAG6 P46379 Large proline-rich protein BAG6 Yes Yes Yes BROX Q5VW32 BRO1 domaincontaining protein BROX Yes Yes CHMP1A Q9HD42 Charged multivesicular body protein 1a Yes Yes...”
- SAV-Pred: A Freely Available Web Application for the Prediction of Pathogenic Amino Acid Substitutions for Monogenic Hereditary Diseases Studied in Newborn Screening.
Zadorozhny, International journal of molecular sciences 2023 - “...P04424-1 9 29 288 326 7 9 0.850 0.853 ASS1 Homocystinuria Citrullinemia, type I 603470 P00966 10 25 162 197 13 6 0.787 0.792 BTD Biotinidase deficiency 609019 P43251-1 5 133 317 455 17 15 0.849 0.830 CFTR Cystic fibrosis 219700 P13569-1 56 350 697 1103...”
- Proteomic analysis of holocarboxylase synthetase deficient-MDA-MB-231 breast cancer cells revealed the biochemical changes associated with cell death, impaired growth signaling, and metabolism.
Sukjoi, Frontiers in molecular biosciences 2023 - “...1.1 1.5 1.5 Q9NQ25 SLAMF7 SLAM family member 7 2.0 3.4 2.5 5.8 Metabolic process P00966 ASS1 Argininosuccinate synthase 1 3.3 17.0 2.8 17.0 P04114 APOB Apolipoprotein B-100 1.0 1.5 1.3 2.7 P14618-2 PKM1 Isoform M1 of Pyruvate kinase PKM 1.1 2.7 1.7 7.6 P17900 GM2A...”
- Tissue-Based Proteomic Profiling in Patients with Hyperplasia and Endometrial Cancer
Akkour, Cells 2022 - “...Transketolase TKT_HUMAN 0.034 2.17 UP 48 1067 P17661 Desmin DESM_HUMAN 0.038 2.10 UP 49 313 P00966 Argininosuccinate synthase ASSY_HUMAN 0.04 2.03 DOWN 50 896 P17661 Desmin DESM_HUMAN 0.04 2.31 UP 51 231 P62937 Peptidyl-prolyl cis-trans isomerase A PPIA_HUMAN 0.042 2.12 DOWN 52 905 P04406 Glyceraldehyde-3-phosphate dehydrogenase...”
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- A pan-cancer analysis of the role of argininosuccinate synthase 1 in human tumors
Ding, Frontiers in oncology 2023 - “...data In this study, we explored the role of human ASS1 (NM_000050 for mRNA or NP_000041 for protein) in tumors. We first analyzed the expression of ASS1 in different tumors and non-tumor tissues. The TIMER2 database was used to analyze the expression of the ASS1 gene...”
- “...different tumors. Based on the CPTAC dataset, we analyzed the expression level of ASS1 phosphoprotein (NP_000041, T174, T219, Y113, and S115 sites) between normal tissue and primary tissue of selected tumors via the UALCAN. 3.5 Immune infiltration analysis data It is trusted that the tumor microenvironment...”
- Serum extracellular vesicle-derived ASS1 is a promising predictor for the occurrence of HEV-ALF.
Xiang, Journal of medical virology 2023 (PubMed)- GeneRIF: Serum extracellular vesicle-derived ASS1 is a promising predictor for the occurrence of HEV-ALF.
- BAP1 Loss Is Associated with Higher ASS1 Expression in Epithelioid Mesothelioma: Implications for Therapeutic Stratification.
Barnett, Molecular cancer research : MCR 2023 - GeneRIF: BAP1 Loss Is Associated with Higher ASS1 Expression in Epithelioid Mesothelioma: Implications for Therapeutic Stratification.
- Analysis of ASS1 gene in ten unrelated middle eastern families with citrullinemia type 1 identifies rare and novel variants.
Daou, Molecular genetics & genomic medicine 2023 - GeneRIF: Analysis of ASS1 gene in ten unrelated middle eastern families with citrullinemia type 1 identifies rare and novel variants.
- Downregulation of argininosuccinate synthase 1 (ASS1) is associated with hypoxia in placental development.
Fantone, Human cell 2023 (PubMed)- GeneRIF: Downregulation of argininosuccinate synthase 1 (ASS1) is associated with hypoxia in placental development.
- Polymorphic Variants of ASS1 Gene Related to Arginine Metabolism and the Risk of HCC.
Bibi, Protein and peptide letters 2023 (PubMed)- GeneRIF: Polymorphic Variants of ASS1 Gene Related to Arginine Metabolism and the Risk of HCC.
- [Clinical and ASS1 gene variant analysis of three Chinese pedigrees affected with Citrullinemia type I].
Dong, Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 2023 (PubMed)- GeneRIF: [Clinical and ASS1 gene variant analysis of three Chinese pedigrees affected with Citrullinemia type I].
- PGAM1 regulation of ASS1 contributes to the progression of breast cancer through the cAMP/AMPK/CEBPB pathway.
Liu, Molecular oncology 2022 - GeneRIF: PGAM1 regulation of ASS1 contributes to the progression of breast cancer through the cAMP/AMPK/CEBPB pathway.
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YOL058W Arg1p from Saccharomyces cerevisiae
38% identity, 91% coverage
- Differential requirements for Gcn5 and NuA4 HAT activities in the starvation-induced versus basal transcriptomes
Zheng, Nucleic acids research 2023 - “...YMR062C YMR251W-A YNL036W YNL104C YNL125C YNR069C YOL052C-A YOL058W YOR130C YOR230W YOR337W YPL135W YPL250C YPR036W-A YBR145W YBR218C YBR249C YCL030C YCR005C...”
- Waffle Method: A general and flexible approach for improving throughput in FIB-milling
Kelley, Nature communications 2022 - “...individually milled at shallow angles (<15). Yeast cells sample preparation The yeast strain Saccharomyces cerevisiae YOL058W was grown on solid YPD media at 30C. Cells were harvested from the plate and centrifuged in liquid YPD media for 4min at ~4,200 g at 4C. The cell pellet...”
- A consensus multi-view multi-objective gene selection approach for improved sample classification
Acharya, BMC bioinformatics 2020 - “...are co-expressed. The IDs of 10 selected genes in the reduced gene-space are YBL084C, YGR152C, YOL058W, YDR379W, YDR165W, YLR325C, YFL008W, YLR103C, YPL150W, YOL047C. Similar to Multiple tissues , with the original (2884 genes) as well as reduced gene expression Yeast data sets by different approaches, we...”
- Transcriptional profiling reveals molecular basis and novel genetic targets for improved resistance to multiple fermentation inhibitors in Saccharomyces cerevisiae
Chen, Biotechnology for biofuels 2016 - “...YJR139C, YKL001C, YKR080W, YLR058C, YLR142W , YLR180W, YLR231C, YLR303W, YMR169C , YMR189W, YMR300C, YNL135C, YNL160W, YOL058W, YOL086C, YOR184W, YOR375C YCL030C, YDR007W, YDR502C , YER091C , YGL245W, YGL256W , YJL200C, YJR016C, YLR142W , YMR169C , YMR250W YCL030C, YCR005C, YDL168W, YDL182W, YDR007W, YDR135C, YDR502C , YDR513W, YEL046C, YER043C,...”
- Global translational impacts of the loss of the tRNA modification t6A in yeast
Thiaville, Microbial cell (Graz, Austria) 2016 - “...function* YMR096W SNZ1 Protein involved in vitamin B6 biosynthesis* YNL104C LEU4 Alpha-isopropylmalate synthase (2-isopropylmalate synthase)* YOL058W ARG1 Arginosuccinate synthetase* & YOR130C ORT1 Ornithine transporter of the mitochondrial inner membrane* A discrete but not a global increase in translational ambiguity is observed in the t 6 A...”
- The Recent De Novo Origin of Protein C-Termini
Andreatta, Genome biology and evolution 2015 - “...Frameshift 2 Low Strong pH sensor; involved in cell wall biosynthesis and alkaline pH response YOL058W ARG1 S. cer 420 714 722 Deletion 3 Strong Strong Arginosuccinate synthetase activity; involved in the arginine biosynthesis pathway YOL086C ADH1 S. cer 349 7 18 Frameshift 2 Strong Strong...”
- “...additions have risen to high frequency. One extremely long addition (714 amino acids added to YOL058W) appeared to be the result of a 288 bp deletion that removed nine C-terminal amino acids, the ancestral stop codon and all of the 3-UTR. The deletion ended in the...”
- The mitochondrial quality control protein Yme1 is necessary to prevent defective mitophagy in a yeast model of Barth syndrome
Gaspard, The Journal of biological chemistry 2015 - “...ARG3 YJL088W CPA1 YOR303W CPA2 YJR109C ARG1 YOL058W Mitochondrial iron metabolism ISA2 GGC1 Mitochondrial iron metabolism FRE4 SIT1 Mitochondrial protein import...”
- setsApp for Cytoscape: Set operations for Cytoscape Nodes and Edges
Morris, F1000Research 2014 - “...If we name the resulting set GAL- we see that it contains a single gene: YOL058W (ARG1). In this data set of 331 genes, only this one gene is repressed for all three of the deleted GAL genes. In the absence of galactose when GAL80 is...”
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FOXG_13797 argininosuccinate synthase from Fusarium oxysporum f. sp. lycopersici 4287
35% identity, 85% coverage
ASSY_YEAST / P22768 Argininosuccinate synthase; Citrulline--aspartate ligase; EC 6.3.4.5 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 5 papers)
NP_014583 argininosuccinate synthase from Saccharomyces cerevisiae S288C
38% identity, 91% coverage
2nz2A / P00966 Crystal structure of human argininosuccinate synthase in complex with aspartate and citrulline (see paper)
36% identity, 92% coverage
- Ligands: aspartic acid; citrulline (2nz2A)
PADG_00888 argininosuccinate synthase from Paracoccidioides brasiliensis Pb18
39% identity, 88% coverage
- Molecular Interactions of the Copper Chaperone Atx1 of Paracoccidioides brasiliensis with Fungal Proteins Suggest a Crosstalk between Iron and Copper Homeostasis
de, Microorganisms 2023 - “...by using pull-down assays identified through LC-MS/MS. Accession a Description Score Sequence Coverage Peptides b PADG_00888 Argininosuccinate synthase 797.87 14.22 6 PADG_01886 Adenosylhomocysteinase 1375.59 27.52 14 PADG_04167 Aspartyl aminopeptidase 863.77 21.96 13 PADG_03449 Isopentenyl-diphosphate delta-isomerase 872.73 13.28 8 PADG_00221 Short-chain dehydrogenase 1357.70 21.4 9 PADG_05081 Aldehyde...”
- Molecular characterization of siderophore biosynthesis in Paracoccidioides brasiliensis
Silva, IMA fungus 2020 - “...as arginase (PADG_00637), ornithine aminotransferase (PADG_01328), glutamate-5-semialdehyde dehydrogenase (PADG_05337), NADP-specific glutamate dehydrogenase (PADG_04516), arginosuccinate synthase (PADG_00888), hydroxymethylglutaryl-CoA lyase (PADG_07031) and acetyl-CoA acetyltransferase (PADG_2751), which are related to the synthesis of ornithine, arginine and acetyl-CoA, respectively, were identified in the proteome. Notably, only SidA was down regulated...”
- “...1171.88 PADG_01328 Ornithine aminotransferase (461 aa) 6h 2299.86 PADG_01328 Ornithine aminotransferase (461 aa) 24h 1175.4 PADG_00888 Argininosuccinate synthase (416 aa) 6h 3507.13 PADG_00888 Argininosuccinate synthase (416 aa) 24h 4840.6 PADG_07031 Hydroxymethylglutaryl-CoA lyase (357 aa) 6h 2406.52 PADG_07031 Hydroxymethylglutaryl-CoA lyase (357 aa) 24h 2627.2 PADG_05337 Glutamate-5-semialdehyde dehydrogenase...”
LOC107453461 argininosuccinate synthase from Parasteatoda tepidariorum
37% identity, 91% coverage
FGSG_06098 argininosuccinate synthase from Fusarium graminearum PH-1
36% identity, 96% coverage
BPSL1721 putative argininosuccinate synthase from Burkholderia pseudomallei K96243
35% identity, 91% coverage
PAAG_07114 argininosuccinate synthase from Paracoccidioides lutzii Pb01
38% identity, 88% coverage
- Proteomic profile response of Paracoccidioides lutzii to the antifungal argentilactone
Prado, Frontiers in microbiology 2015 - “...Protein score Fold change METABOLISM Amino acid metabolism Acetolactate synthase PAAG_00221 849.43 0.726 Argininosuccinate synthase PAAG_07114 6934.38 0.522 Cobalamin-independent methionine synthase MetH/D PAAG_07626 2518.10 0.577 Isovaleryl-CoA dehydrogenase, mitochondrial PAAG_04102 953.65 0.811 NADP-specific glutamate dehydrogenase PAAG_07689 1723.70 0.600 Ornithine aminotransferase PAAG_06431 1262.54 0.684 Lysine decarboxylase-like protein PAAG_03537...”
E3JT53 argininosuccinate synthase from Puccinia graminis f. sp. tritici (strain CRL 75-36-700-3 / race SCCL)
36% identity, 90% coverage
HL033_04485 argininosuccinate synthase from Neoehrlichia mikurensis
37% identity, 86% coverage
PD0291 argininosuccinate synthase from Xylella fastidiosa Temecula1
36% identity, 92% coverage
ING2E5A_0737 argininosuccinate synthase from Petrimonas mucosa
35% identity, 90% coverage
XF0999 argininosuccinate synthase from Xylella fastidiosa 9a5c
35% identity, 92% coverage
- Xylella fastidiosa subsp. pauca Strains Fb7 and 9a5c from Citrus Display Differential Behavior, Secretome, and Plant Virulence
de, International journal of molecular sciences 2020 - “...main proteins identified with higher abundance in strain Fb7 by LC-MS/MS (XF0872; XF1742; XF2677; XF0156; XF0999; XF1516) were also investigated at the transcriptional level by RT-qPCR to verify the correlation between transcript levels and their protein products. Among the six protein-coding genes evaluated, five also presented...”
- “...3.59 10 5 11 42 XF1516 VII.F Adhesin XadA1 1.85 2.53 10 5 7 10 XF0999 II.A.1 Argininosuccinate synthase 1.71 1.52 10 6 10 31 XF1123 IV.A.2 Outer membrane protein 1.59 1.68 10 2 3 44 XF1744 IX Oxidoreductase 1.55 3.74 10 6 6 34 XF0619...”
Q0IFL5 Argininosuccinate synthase from Aedes aegypti
32% identity, 94% coverage
A0A401P304 Argininosuccinate synthase from Scyliorhinus torazame
33% identity, 94% coverage
- Mass Spectrometry Analysis of Shark Skin Proteins
Bachar-Wikstrom, International journal of molecular sciences 2023 - “...enzyme in the extracellular space of antigen presenting cells (APCs) during inflammation [ 94 ]. A0A401P304 Argininosuccinate synthase CCS This enzyme channels extracellular L-arginine to nitric oxide synthesis pathway during inflammation [ 52 ]. Q6EE48 Cathepsin B (fragment) SSCS See A0A401PTT0 A0A401PKI6 GDP-mannose 4,6- dehydratase CCS...”
- “...BPNT1 nucleotidase (fragment) A0A401SK27 Calumenin A0A411HEE0 Carbonic anhydrase A0A401RS85 Phosphotriesterase-related protein Accession Number Protein metabolism A0A401P304 Argininosuccinate synthase A0A401NVA0 Protein arginine deiminase K4G395 Serine/threonine protein phosphatase A0A401RW52 Dipeptidyl peptidase 1 A0A401P906 Dipeptidyl peptidase 1 A0A401PKX8 Cytosol aminopeptidase V9KUJ8 S-adenosylmethionine synthase A0A4W3JRE6 Adenosylhomocysteinase V9KVD7 Dimethylargininase (fragment) A0A401S0W3...”
PXO_00352 argininosuccinate synthase from Xanthomonas oryzae pv. oryzae PXO99A
35% identity, 93% coverage
ABZR86_RS08715 arginosuccinate synthetase (EC 6.3.4.5) from Dyella japonica UNC79MFTsu3.2
35% identity, 91% coverage
- mutant phenotype: Important for fitness in most defined media, except when arginine is provided. 35% identical to argininosuccinate synthase from Thermus thermophilus (P59846).
Smlt3301 putative argininosuccinate synthase from Stenotrophomonas maltophilia K279a
34% identity, 93% coverage
SPRG_19437 argininosuccinate synthase from Saprolegnia parasitica CBS 223.65
32% identity, 92% coverage
- Analysis of Saprolegnia parasitica Transcriptome following Treatment with Copper Sulfate
Hu, PloS one 2016 - “...In the metabolism-related biological pathways, the expression of certain genes (such as SPRG_05378, SPRG_01336, SPRG_00691, SPRG_19437, SPRG_17560, SPRG_13611, SPRG_08603, SPRG_09764, and SPRG_01617) were upregulated, while SPRG_11730, SPRG_04491, SPRG_10490, SPRG_12259, SPRG_04186, SPRG_18377, SPRG_18063, SPRG_06771, SPRG_16261, and SPRG_02541 genes were downregulated after copper sulfate treatment. These findings were...”
A0A0B4F537 argininosuccinate synthase (Fragment) from Metarhizium anisopliae (strain ARSEF 549)
32% identity, 90% coverage
BF9343_0461 argininosuccinate synthase from Bacteroides fragilis NCTC 9343
29% identity, 90% coverage
- Multi-omics approach for understanding the response of Bacteroides fragilis to carbapenems
Zholdybayeva, Heliyon 2024 - “...GntR family transcriptional regulator 5,11E+00 epimerase activity BF9343_0294 Aldose 1-epimerase (galM) 1,16E+00 argininosuccinate synthase activity BF9343_0461 argininosuccinate synthase 7,18E-01 protein tyrosine phosphatase activity BF9343_2868 Tyrosine specific protein phosphatases 4,83E+00 voltage-gated chloride channel activity BF9343_3575 Chloride channel protein (clcB) 1,78E+00 methyltransferase activity, BF9343_0858 SAM-dependent methyltransferase 1,21E+00 dipeptidase...”
- “...6 GOTERM BP Count P value Enrichment score GO:0044763single-organism cellular process: 4 0.0375 0.767 1 BF9343_0461 (argininosuccinate synthase (argG) 2 BF9343_0873 (O-acetylhomoserine synthase (mdeA_2) 3 BF9343_3455 (acyl-ACP thioesterase) 4 BF9343_3810 (putative transmembrane protein (BF9343_3810) GO:0019752carboxylic acid metabolic process 3 0.0544 0.767 BF9343_0461 (argininosuccinate synthase (argG) BF9343_3455...”
BT3760 arginosuccinate synthetase (EC 6.3.4.5) from Bacteroides thetaiotaomicron VPI-5482
BT3760 argininosuccinate synthase from Bacteroides thetaiotaomicron VPI-5482
28% identity, 91% coverage
- mutant phenotype: Important for fitness in most defined media, except when arginine is provided. 32% identical to argininosuccinate synthase from Leishmania (H9BG20).
- Functional genetics of human gut commensal Bacteroides thetaiotaomicron reveals metabolic requirements for growth across environments
Liu, Cell reports 2021 - “...involved in arginine biosynthesis (BT3759, homologous to argC in E. coli ; BT3733, argH ; BT3760, argG ; and BT3395, argB ). Furthermore, BT3761 was critical for growth on minimal media without amino acids, and its fitness defect was rescued through addition of arginine ( Figure...”
- GapMind: Automated Annotation of Amino Acid Biosynthesis
Price, mSystems 2020 - “...), which creates some uncertainty about its role. The final gap was argininosuccinate synthase (ArgH). BT3760 was identified as a moderate-confidence candidate because it is less than 40% identical to any characterized enzyme. Using the genetic data for B. thetaiotaomicron , we had previously identified that...”
An12g01280 uncharacterized protein from Aspergillus niger
30% identity, 81% coverage
HI1727 argininosuccinate synthetase (argG) from Haemophilus influenzae Rd KW20
28% identity, 77% coverage
5us8A / Q7VTJ9 2.15 angstrom resolution crystal structure of argininosuccinate synthase from bordetella pertussis
28% identity, 82% coverage
- Ligand: adenosine (5us8A)
BB1986 argininosuccinate synthase from Bordetella bronchiseptica RB50
27% identity, 82% coverage
LV28_16050 argininosuccinate synthase from Pandoraea pnomenusa
28% identity, 77% coverage
- Complete Genome Sequence Analysis of Pandoraea pnomenusa Type Strain DSM 16536(T) Isolated from a Cystic Fibrosis Patient
Lim, Frontiers in microbiology 2016 - “...imidazole glycerol phosphate synthase cyclase subunit (LV28_12510), translation elongation factor Tu (LV28_12945; LV28_13105), argininosuccinate synthase (LV28_16050), endonuclease III (LV28_23310), 3-isopropylmalate dehydrogenase (LV28_23930), 3-isopropylmalate dehydrogenase (LV28_23930), RNA-binding protein Hfq (LV28_24345), chorismate synthase (LV28_04475), acetolactate synthase large and small subunit (LV28_04625 and LV28_04620), and chemotaxis protein CheY (LV28_14025)....”
PPA2201 argininosuccinate synthase from Propionibacterium acnes KPA171202
28% identity, 76% coverage
- Comparative genomics and transcriptomics of Propionibacterium acnes
Brzuszkiewicz, PloS one 2011 - “...higher in stationary phase). By contrast, genes involved in arginine biosynthesis such as argininosuccinate synthase (PPA2201), converting aspartate and citrulline into argininosuccinate, and the cluster PPA1347-1350 were upregulated in the SP ( Figure 3 ). The latter encodes enzymes catalyzing the conversion of glutamate to ornithine....”
Sant_2433 argininosuccinate synthase from Sodalis praecaptivus
27% identity, 84% coverage
PFREUD_01460 argininosuccinate synthase from Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1
27% identity, 77% coverage
- A temporal-omic study of Propionibacterium freudenreichii CIRM-BIA1 adaptation strategies in conditions mimicking cheese ripening in the cold
Dalmasso, PloS one 2012 - “...dehydrogenase AA 4.3 7.3 6.8 6.6 3.00E-06 9.5 0.042 0.8 0.8 1.4 5.70E-05 36 argG PFREUD_01460 Argininosuccinate synthase AA 0.4 2.9 2.3 0.6 0.003 4.1 0.019 bkdA2 PFREUD_02200 Branched-chain -keto acid dehydrogenase AA 0.9 3.2 3 2.5 0.011 4.2 0.024 tyrB PFREUD_09460 Aspartate transaminase AA 0.9...”
- “...PCR (RT-qPCR). Gene Primer sequences Name Locus tag Forward Reverse ald PFREUD_00370 TGTTCACCTACCTGCACCTG GAGCTCAACCGTCTCGTAGG argG PFREUD_01460 GACCATCAACGGCAAGAAGT TCGTAGGCGATGAACAACAG argJ PFREUD_13980 GCATGTCCACGAACGACTC AACTGGTGTCCCAGGTTGAG aspA2 PFREUD_16330 TCCACGCGTACAGAAGAAGA CCGGACATCTGGAAGTTCTC bkdA2 PFREUD_02200 TCGCATTTCGTACACACTCC TTCGGCTCGAAGAAGATCAC cspB PFREUD_18210 GCGATGATGGAGGATTTGAT CGATCTTTGAGGCCTGACC cstA PFREUD_16500 CCTACACACCGGAGGAAGAG GGACCGTCCATTTGTTATGC dps PFREUD_02870 GACCTGGTCGTGAAGTCGAT GCTTGTTGATCAGCTCATGG eno1 PFREUD_17320 TACGAGTTCGAGGGCAAGTC AAACCAGCGGGTAGTCATTG...”
1kp3A / P0A6E4 Crystal structure of e. Coli argininosuccinate synthetase in complex with atp and citrulline (see paper)
26% identity, 86% coverage
- Ligands: adenosine-5'-triphosphate; citrulline (1kp3A)
SLIV_04065 argininosuccinate synthase from Streptomyces lividans TK24
SCO7036 argininosuccinate synthase from Streptomyces coelicolor A3(2)
27% identity, 76% coverage
- Enhanced protein secretion in reduced genome strains of Streptomyces lividans
Hamed, Microbial cell factories 2024 - “...argH ( SLIV_29875) , argC ( SLIV_29825 ), argJ ( SLIV_29830 ) and argG ( SLIV_04065 )]. These genes may play a key role in cell-wall biosynthesis, since glutamine derived from glutamate is a major component of peptidoglycan. Alternatively, one cannot exclude that arg biosynthesis is...”
- Functional connexion of bacterioferritin in antibiotic production and morphological differentiation in Streptomyces coelicolor
García-Martín, Microbial cell factories 2024 - “...SerA (SCO5515, only detected on day 3), for serine biosynthesis [ 150 ], and ArgG (SCO7036), for arginine biosynthesis [ 151 ]. Ribosome and DNA Eight ribosomal proteins, seven from 30S subunit (RpsD/SCO1505, RpsT/SCO2563, RpsR1/SCO3908, RpsL/SCO4659, RpsN1/SCO4715, RpsI/SCO4735, and RpsP/SCO5591) and one from 50S subunit (RpmB1/SCO5564),...”
- Mutational meltdown of putative microbial altruists in Streptomyces coelicolor colonies
Zhang, Nature communications 2022 - “...at least 322kb 21 , 22 and arginine auxotrophy, due to the loss of argG (SCO7036), corresponds to a deletion of at least 843kb 23 . In addition, we analyzed changes to resistance to three other antibiotics. As is evident in Fig. 2a , whereas the...”
- Antibiotic production in Streptomyces is organized by a division of labor through terminal genomic differentiation
Zhang, Science advances 2020 - “...discussed below, deletions to the right chromosome arm cause the loss of two loci, argG (SCO7036) and cmlR1 (SCO7526) /cmlR2 (SCO7662), that result in two easily scorable phenotypes: arginine auxotrophy and chloramphenicol susceptibility, respectively. Scoring these phenotypes allows rapid determination of the minimal size of the...”
- ArgR of Streptomyces coelicolor Is a Pleiotropic Transcriptional Regulator: Effect on the Transcriptome, Antibiotic Production, and Differentiation in Liquid Cultures
Botas, Frontiers in microbiology 2018 - “...CGCTGTATAGAAATTCAGAA 6550325 6550344 55 8.2 SCO5976 arcB Ornithine carbamoyltransferase AB.SCO5976_2 GTTCGTATAGACTTCCAGAA 6550345 6550364 35 9.6 SCO7036 a argG Argininosuccinate synthase AB.SCO7036_1 CTTTGCATGGTCATGCGTAA 7824734 7824753 18 17.2 SCO7036 argG Argininosuccinate synthase AB.SCO7036_2 TGATGCATACTCTTCCTATG 7824754 7824773 2 8.1 SCO7314 sigM Probable RNA polymerase sigma factor AB.SCO7314_0 ATCCGCATGCTCATAGAAAC 8120535...”
- Transcriptomic analysis of a classical model of carbon catabolite regulation in Streptomyces coelicolor
Romero-Rodríguez, BMC microbiology 2016 - “...SCO5976 arcB, StBAC16H6.11 Ornithine carbamoyltransferase [EC:2.1.3.3] SCO6266 ScbA protein SCO6268 Histidine kinase SCO6288 Regulatory protein SCO7036 argG, SC4G1.02 Argininosuccinate synthase [EC:6.3.4.5] SCO7262 Hypothetical protein SCO7530 Regulatory protein SCO7586 Oxidoreductase SCO7587 Integral membrane protein SCO7698 MerR-family transcriptional regulator Role of ScGlk in carbon catabolite repression As previously...”
- ArgR of Streptomyces coelicolor is a versatile regulator
Pérez-Redondo, PloS one 2012 - “...in three separate genes: argH (SCO1570), arcB (SCO5976, located in the arc cluster) and argG (SCO7036) ( Fig. 4 ). Genes involved in the formation of carbamoyl-phosphate ( carAB ) and required to form citrulline from ornithine will be considered in the next section. Our transcriptional...”
- “...cystathionine gamma-synthase 0.027 Down 6340 SCO6282 (a) cpkI enoyl-(acyl carrier protein) reductase 0.017 Down 6513 SCO7036 (a) argG argininosuccinate synthase 0.000 Up 6771 SCO7510 cypH peptidyl-prolyl cis-trans isomerase 0.009 Down 6317 SCO7511 gap2 glyceraldehyde 3-phosphate dehydrogenase 0.026 Down (1) spot identification number automatically generated from ImageMaster...”
- Role of an FtsK-like protein in genetic stability in Streptomyces coelicolor A3(2)
Wang, Journal of bacteriology 2007 - “...used to amplify a 693-bp fragment in argG (SCO7036) in PCR6. Fluorescence microscopy. A previously described method (27) was used with minor modification....”
- “...a segment 841 kb from the right end, in argG (SCO7036; PCR6). With very few exceptions, the absence of any one segment was associated with the absence of all...”
YPO1570 argininosuccinate synthase from Yersinia pestis CO92
Q8ZFV7 Argininosuccinate synthase from Yersinia pestis
YPTB1579 argininosuccinate synthase from Yersinia pseudotuberculosis IP 32953
29% identity, 62% coverage
FQU82_01177, HMPREF0010_02972 argininosuccinate synthase from Acinetobacter baumannii ATCC 19606 = CIP 70.34 = JCM 6841
29% identity, 61% coverage
- Transcriptomic analysis reveals the regulatory role of quorum sensing in the Acinetobacter baumannii ATCC 19606 via RNA-seq
Xiong, BMC microbiology 2022 - “...downregulated. Among the DEGs involved in the arginine biosynthesis, FQU82_00067 and FQU82_01752 were upregulated, whereas FQU82_01177, FQU82_02901, FQU82_01050 ( ureC ), FQU82_01049 ( ureB ), and FQU82_01048 ( ureA ) were downregulated. Arginine was one of the common amino acids required for protein synthesis in bacteria,...”
- Constraint-based modeling identifies new putative targets to fight colistin-resistant A. baumannii infections
Presta, Scientific reports 2017 - “...no no no yes HMPREF0010_02048 carbamoyl-phosphate synthase small subunit no yes no no no yes HMPREF0010_02972 argininosuccinate synthase no yes no no no yes HMPREF0010_03445 34-dihydroxy-2-butanone 4-phosphate synthase no yes no no no no HMPREF0010_00048 sugar kinase no yes no no no no HMPREF0010_02330 glutamine synthetase...”
- “...represent a suitable horizon in the field of colistin-coupled treatment. The four genes, named HMPREF0010_00949, HMPREF0010_02972 and HMPREF0010_03445, HMPREF0010_01216 respectively encode a malonate decarboxylase (epsilon subunit), an arginine succinate synthase, a 3-4-dihydroxy-2-butanone-4-phopsphate synthase and a quinolate synthase. Interestingly, malonate decarboxylase epsilon subunit has already been characterized...”
AB57_1152 argininosuccinate synthase from Acinetobacter baumannii AB0057
29% identity, 62% coverage
STM3290 argininosuccinate synthetase from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
26% identity, 73% coverage
- Transcriptomic Responses of Salmonella enterica Serovars Enteritidis in Sodium Hypochlorite
Wang, Frontiers in cellular and infection microbiology 2022 - “...STM0738 sucC -1.4 ADP-forming succinateCoA ligase subunit beta STM0739 sucD -1.2 succinateCoA ligase subunit alpha STM3290 argG -1.5 argininosuccinate synthetase STM0734 sdhA -3.2 succinate dehydrogenase flavoprotein subunit STM0733 sdhD -3.0 succinate dehydrogenase membrane anchor subunit STM0735 sdhB -2.8 succinate dehydrogenase iron-sulfur protein STM0732 sdhC -3.4 succinate...”
- Intraspecies variation in the emergence of hyperinfectious bacterial strains in nature
Heithoff, PLoS pathogens 2012 - “...Acetylglutamate kinase [91] . STM3468 argD 1.26 2.84 4.31 Bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein [91] . STM3290 argG 0.17 1.54 1.24 Arginosuccinate synthase [91] . STM4123 argH 0.20 1.53 2.10 Arginosuccinate lyase [91] . STM4469 argI 0.36 2.05 3.19 Ornithine transcarbamylase [91] . STM0887 artJ 0.78 1.76...”
STM3290.S argininosuccinate synthase from Salmonella typhimurium LT2
STM14_3973 argininosuccinate synthase from Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S
26% identity, 77% coverage
ArgG / b3172 argininosuccinate synthetase (EC 6.3.4.5) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
ASSY_ECOLI / P0A6E4 Argininosuccinate synthase; Citrulline--aspartate ligase; EC 6.3.4.5 from Escherichia coli (strain K12) (see 2 papers)
argG / RF|NP_417640 argininosuccinate synthase from Escherichia coli K12 (see paper)
NP_417640 argininosuccinate synthetase from Escherichia coli str. K-12 substr. MG1655
b3172 argininosuccinate synthase from Escherichia coli str. K-12 substr. MG1655
c3929 Argininosuccinate synthase from Escherichia coli CFT073
27% identity, 77% coverage
- catalytic activity: L-citrulline + L-aspartate + ATP = 2-(N(omega)-L- arginino)succinate + AMP + diphosphate + H(+) (RHEA:10932)
subunit: Homotetramer. - Biodistribution of 89Zr-DFO-labeled avian pathogenic Escherichia coli outer membrane vesicles by PET imaging in chickens
Li, Poultry science 2023 - “...wall/membrane/envelope biogenesis Cytoplasm 138 P0A9A6 FTSZ Cell cycle control, cell division, chromosome partitioning Cytoplasm 139 P0A6E4 ASSY Amino acid transport and metabolism Cytoplasm 140 P0A6E9 BIOD2 Coenzyme transport and metabolism Cytoplasm 141 P0A6Y8 DNAK Posttranslational modification, protein turnover, chaperones Cytoplasm 142 P0A8V6 FADR Transcription Cytoplasm 143...”
- Open Issues for Protein Function Assignment in Haloferax volcanii and Other Halophilic Archaea
Pfeiffer, Genes 2021 - “...yes 35% - P00966 [ 134 ] 8792870 human 2a HVO_0049 (cont.) yes 23% b3172 P0A6E4 [ 135 ] 10666579 E. coli 2a HVO_0048 argH yes 38% MMP0013 O74026 [ 136 ] 10220900 2a HVO_0008 lysC yes 32% BSU28470 P08495 [ 137 ] 15033471 2a HVO_2487...”
- Molecular analysis of an alternative N-glycosylation machinery by functional transfer from Actinobacillus pleuropneumoniae to Escherichia coli
Naegeli, The Journal of biological chemistry 2014 - “...protein P39180 Ag43 Antigen 43 P22259 P0A6E4 P37636 PCKA ArgG MdtE Phosphoenolpyruvate carboxykinase Argininosuccinate synthase Multidrug resistance protein...”
- The Escherichia coli proteome: past, present, and future prospects
Han, Microbiology and molecular biology reviews : MMBR 2006 - “...5.73/30,486 (5-6) 5.86/29,835 (5.5-6.7) ArgG P0A6E4 Argininosuccinate synthase 5.23/49,767.20 ArgI P04391 5.46/36,775.92 ArgS P11875 Ornithine...”
- Sequences of the genes encoding argininosuccinate synthetase in Escherichia coli and Saccharomyces cerevisiae: comparison with methanogenic archaebacteria and mammals.
Van, Gene 1990 (PubMed)- GeneRIF: N-terminus verified by Edman degradation on mature peptide
- A workflow for annotating the knowledge gaps in metabolic reconstructions using known and hypothetical reactions
Vayena, Proceedings of the National Academy of Sciences of the United States of America 2022 - “...N2-succinyl-L-ornithine (EC 3.5.3.-), which provided an alternative pathway to compensate for the knockout of argG (b3172). The second added gene, LacA (b0342), encodes the enzyme galactoside O-acetyltransferase, which catalyzes the transfer of an acetyl group from acetyl-CoA to the 6-hydroxyl of some galactopyranosides ( 27 )....”
- Open Issues for Protein Function Assignment in Haloferax volcanii and Other Halophilic Archaea
Pfeiffer, Genes 2021 - “...argG yes 35% - P00966 [ 134 ] 8792870 human 2a HVO_0049 (cont.) yes 23% b3172 P0A6E4 [ 135 ] 10666579 E. coli 2a HVO_0048 argH yes 38% MMP0013 O74026 [ 136 ] 10220900 2a HVO_0008 lysC yes 32% BSU28470 P08495 [ 137 ] 15033471 2a...”
- Complete Genome Sequence of ER2796, a DNA Methyltransferase-Deficient Strain of Escherichia coli K-12
Anton, PloS one 2015 - “...(G) E33stop ER2796_2821 (from internal start at aa 40) argG6 (Fs) argG6 1 frameshift argG (b3172) between 33045613304562 3317286 (C) 210447 ER2796_3265 (aa 1209 + 13 aa), and ER2796_3266 (from internal start at aa 221) rpsL104 missense rpsL (b3342) 3443238 (G) 3472313 (T) K88Q missense rpsL...”
- A system-level model for the microbial regulatory genome
Brooks, Molecular systems biology 2014 - “...MetR ArgR 512157;554056 b2913 b3941 0.932025 PurR MetR 512157 b3957 b3941 0.931565 ArgR MetR 512157;554056 b3172 b3829 0.930382 ArgR MetR 512157;554056 b2913 b3774 0.927776 PurR IlvY 512157;512477 b3941 b3774 0.927251 MetR IlvY 512157 b3960 b3941 0.921375 ArgR MetR 512157;554056 b3941 b3959 0.921282 MetR ArgR 512157;554056 EGRIN...”
- Global transcriptomic analysis of an engineered Escherichia coli strain lacking the phosphoenolpyruvate: carbohydrate phosphotransferase system during shikimic acid production in rich culture medium
Cortés-Tolalpa, Microbial cell factories 2014 - “...N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase Amino acid metabolism 21.9053 argE b3957 Acetylornithine deacetylase Amino acid metabolism 18.7485 argG b3172 Argininosuccinate synthase Amino acid metabolism 65.2192 argH b3960 Argininosuccinate lyase Amino acid metabolism 23.7859 argI b4254 Ornithine carbamoyltransferase chain I Amino acid metabolism 33.2672 carA b0032 Polypeptide: CarA Amino acid...”
- Gap-filling analysis of the iJO1366 Escherichia coli metabolic network reconstruction for discovery of metabolic functions
Orth, BMC systems biology 2012 - “...al. [ 10 ] cysD (b2752) only experimental growth under one condition, possible error argG (b3172) only experimental growth under one condition, possible error cysG (b3368) only experimental growth under one condition, possible error bioH (b3412) possibly biotin in media due to incomplete washing ilvE (b3770)...”
- “...identified thyA (b2827) none identified zupT (b3040) none identified folB (b3058) folX (b2303) 1.00E-4 argG (b3172) none identified folP (b3177) none identified yrbG (b3196) none identified kdsC (b3198) none identified argD (b3359) astC (b1748) 1.00E-146 gabT (b2662) 3.00E-64 puuE (b1302) 3.00E-54 patA (b3073) 4.00E-52 hemL (b0154)...”
- Genome-scale analysis to the impact of gene deletion on the metabolism of E. coli: constraint-based simulation approach
Xu, BMC bioinformatics 2009 - “...b0522, b0523 b2687 b0386 b2585 b1092 b0945, b1062 b2942 b2818 b3018 b1094 b1131, b1281 b3939 b3172 b4041 b2316 b2312, b2476 b4013 b3957 b4160 b2323 b2499, b2507 s0001 b3958 b3255 b2557, b2780 b3959 b3256 b3642, b4005 b3960 b4006, b4177 s0001 b4244, b4245 SS NSP CAC GSM TTPM...”
- Experimental and computational assessment of conditionally essential genes in Escherichia coli
Joyce, Journal of bacteriology 2006 - “...(b2423) argB (b3959); argC (b3958); argD (b3359); argG (b3172) aspC (b0928) ilvY (b3773); ilvE (b3770); lrp (b0889) aldA (b1415) coaA (b3974); coaE (b0103);...”
- More
- Substantial Extracellular Metabolic Differences Found Between Phylogenetically Closely Related Probiotic and Pathogenic Strains of Escherichia coli
van, Frontiers in microbiology 2019 - “...Identical amino acid sequences were also observed across these strains for enzymes EC 6.3.4.5 (ArgG c3929), EC 4.3.2.1 (ArgH c4919), EC 2.1.3.3 (ArgI c5353; c5348) & EC 3.5.1.16 (ArgE c4916). Thus, E. coli strains Nissle 1971, ABU87932 and NCTC12241/ATCC25922 share all indicated gene products whilst E....”
- Fitness of Escherichia coli during urinary tract infection requires gluconeogenesis and the TCA cycle
Alteri, PLoS pathogens 2009 - “...3.90E-07 UxuA c5402 mannonate dehydratase 3.76 7.20E-03 NanA c3979 N-acetylneuraminate lyase subunit 3.64 4.50E-06 ArgG c3929 argininosuccinate dehydrogenase 3.41 5.80E-03 FklB c5306 peptidyl-prolyl cis trans isomerase 3.38 6.00E-04 NanA c3979 N-acetylneuraminate lyase subunit 3.37 4.50E-06 AtpA c4660 ATP synthase subunit A 3.34 6.30E-05 XylA c4385 xylose...”
- “...YliJ c0923 hypothetical GST protein 2.61 4.00E-04 HisJ c2851 histidine-binding protein precursor 2.55 1.90E-04 ArgG c3929 argininosuccinate dehydrogenase 2.41 2.60E-02 OppA c1707 oligopeptide substrate-binding protein 2.39 7.80E-03 OppA c1707 oligopeptide substrate-binding protein 2.34 2.10E-04 SerA c3494 D-3-phosphoglycerate dehydrogenase 2.28 1.90E-05 YghU c3726 hypothetical GST-like protein 2.27...”
ECs4052 argininosuccinate synthetase from Escherichia coli O157:H7 str. Sakai
27% identity, 77% coverage
P59609 Argininosuccinate synthase from Shigella flexneri
27% identity, 77% coverage
A6TEJ0 Argininosuccinate synthase from Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
26% identity, 84% coverage
BPSL0298 argininosuccinate synthase from Burkholderia pseudomallei K96243
27% identity, 77% coverage
BCAM0746 argininosuccinate synthase from Burkholderia cenocepacia J2315
26% identity, 85% coverage
- The Essential Genome of Burkholderia cenocepacia H111
Higgins, Journal of bacteriology 2017 - “...essentiality of arginine biosynthesis, we constructed conditional BCAM0746 (arginosuccinate synthase gene) mutants in both strain backgrounds (Table 2). While...”
- “...2 Conditional lethal phenotype of the rhamnose-inducible BCAM0746 mutant. Undiluted cultures of mutants grew visibly on plates supplemented with either glucose...”
argG / BAC65286.1 argininosuccinate synthase from Burkholderia multivorans (see paper)
26% identity, 85% coverage
NGO1961 ArgG from Neisseria gonorrhoeae FA 1090
29% identity, 64% coverage
KPK_0542 argininosuccinate synthase from Klebsiella pneumoniae 342
26% identity, 84% coverage
NMB2129 argininosuccinate synthase from Neisseria meningitidis MC58
29% identity, 64% coverage
B7PA12 argininosuccinate synthase (Fragment) from Ixodes scapularis
35% identity, 29% coverage
HVO_0190 conserved hypothetical protein TIGR00268 from Haloferax volcanii DS2
30% identity, 35% coverage
D9S103 PP-loop domain protein from Thermosediminibacter oceani (strain ATCC BAA-1034 / DSM 16646 / JW/IW-1228P)
29% identity, 38% coverage
V5I554 GMP synthase (glutamine-hydrolyzing) (Fragment) from Ixodes ricinus
37% identity, 10% coverage
- Insight Into the Dynamics of the Ixodes ricinus Nymphal Midgut Proteome
Kozelková, Molecular & cellular proteomics : MCP 2023 - “...in fully fed nymphs. The most abundant chitin biosynthetic enzyme was Glutamine: fructose-6-phosphate aminotransferase (GFAT, V5I554) , which was detected in all nymphal stages. Other chitin synthetic enzymes, namely, Phosphoacetylglucosamine mutase (PAGM, A0A131Y3J1) , was identified in FF and molting (14AD and 4wAD) nymphs, and Chitin...”
- “...199 A0A0K8R3P7 JAP72505 3 4.5 - - 17.666 (0.137) - - + Glutamine-aminotransferase (GFAT) 2646 V5I554 JAB83808 61 91.7 21.532 (0.203) 21.929 (0.176) 22.919 (0.498) 21.950 (0.180) 21.744 (0.132) + Phosphoacetyl-glucosamine mutase 678 A0A131Y3J1 JAP72471 7 18.9 - - 16.496 (0.188) 16.641 (0.480) 17.274 (0.162) Chitin...”
GUAA_MOUSE / Q3THK7 GMP synthase [glutamine-hydrolyzing]; GMP synthetase; Glutamine amidotransferase; EC 6.3.5.2 from Mus musculus (Mouse) (see paper)
35% identity, 10% coverage
- function: Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate.
catalytic activity: XMP + L-glutamine + ATP + H2O = GMP + L-glutamate + AMP + diphosphate + 2 H(+) (RHEA:11680)
cofactor: Mg(2+)
subunit: Homodimer. - Mllt11 Regulates Migration and Neurite Outgrowth of Cortical Projection Neurons during Development
Stanton-Turcotte, The Journal of neuroscience : the official journal of the Society for Neuroscience 2022 - “...73.4 5 P20029 Endoplasmic reticulum chaperone BiP (Hspa5) 23.74 10 5 50 655 72.4 5 Q3THK7 GMP synthase [glutamine-hydrolyzing] (Gmps) 8.67 5 3 6 693 76.7 5 O08553 Dihydropyrimidinase-related protein 2 OS = Mus musculus OX = 10090 GN = Dpysl2 PE = 1 SV =...”
- Gel-based protease proteomics for identifying the novel calpain substrates in dopaminergic neuronal cell
Kim, The Journal of biological chemistry 2013 - “...Zfp-35 Zfp35 Plekha5 Map4k1 Hpk1 Q6PDS3 Q9R216 Q3THK7 O54984 Q8CJ19 Enzyme modulator Receptor Transferase Hydrolase Not classified Q8K3K8 Q8BTW8 P15620 E9Q6H8...”
- “...1 ATPase ASNA1 Optineurin Peripherin P97855 Q3THK7 Q60864 O54984 Q8K3K8 P15331 51,829/5.4 76,724/6.3 62,583/6.4 38,823/4.8 67,018/5.2 54,268/5.4 Foldd...”
- Temporal analysis of protein lysine acetylation during adipocyte differentiation.
Xu, Adipocyte 2013 - “...Yes C3d P63101 -43.4 4.73 27 143-3 zeta (tyrosine 3 monooxygenase) Yes Yes Yes C4d Q3THK7 -44.8 6.29 76.7 Glutamine amidotransfrase Yes Yes Yes C5d P17182 -43.1 6.37 47.1 Enolase 1 Yes Yes Yes C6d P63260 -756.5 5.31 41.8 Actin gamma cytoplasmic 1 (Actg1) Yes Yes...”
GUAA_RAT / Q4V7C6 GMP synthase [glutamine-hydrolyzing]; GMP synthetase; Glutamine amidotransferase; EC 6.3.5.2 from Rattus norvegicus (Rat) (see paper)
35% identity, 10% coverage
- function: Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate.
catalytic activity: XMP + L-glutamine + ATP + H2O = GMP + L-glutamate + AMP + diphosphate + 2 H(+) (RHEA:11680)
cofactor: Mg(2+)
subunit: Homodimer. - Prefrontal Cortex Cytosolic Proteome and Machine Learning-Based Predictors of Resilience toward Chronic Social Isolation in Rats.
Filipović, International journal of molecular sciences 2024 - “...0.000 1 0.58 P11598 Protein disulfide-isomerase A3 Pdia3 0.048 0.000 1 0.019 0.007 10 0.55 Q4V7C6 GMP synthase [glutamine-hydrolyzing] Gmps 0.048 0.000 1 1.31 Q62718 Neurotrimin Ntm 0.048 0.000 1 0.49 O35346 Focal adhesion kinase 1 Ptk2 0.048 0.000 1 0.016 0.004 19 1.29 F1LMZ8 26S...”
- Proteomic analysis of spinal cord tissue in a rat model of cancer-induced bone pain.
Yang, Frontiers in molecular neuroscience 2022 - “...Q6P7A2 Ube4a 9.4 3.2 Up P21707 Syt1 9.3 3.2 Up O35314 Chgb 8.7 3.1 Up Q4V7C6 Gmps 8.0 3.0 Up Q4AE70 Carm1 7.5 2.9 Up Q6MGD0 Cuta 7.4 2.9 Up Q99PF5 Khsrp 7.1 2.8 Up Q32PX7 Fubp1 7.1 2.8 Up Q62845 Cntn4 6.6 2.7 Up P53678...”
- The Proteome Profiles of the Cerebellum of Juvenile, Adult and Aged Rats--An Ontogenetic Study
Wille, International journal of molecular sciences 2015 - “...Cndp2 Cytosolic non-specific dipeptidase Cp - - up 0.0106 0.48 5 205 29 53,116 5.43 Q4V7C6 GUAA_RAT Gmps GMP synthase (glutamine-hydrolyzing) Cp up 0.0062 - - 0.52 5 130 17 77,507 6.21 P14882 PCCA_RAT Pcca Propionyl-CoA carboxylase alpha chain, mitochondrial Mmt down 0.0283 - - 2.14...”
- Proteomic analysis of INS-1 rat insulinoma cells: ER stress effects and the protective role of exenatide, a GLP-1 receptor agonist.
Kim, PloS one 2015 - “...SE P value Nucleobase , nucleoside , nucleotide and nucleic acid metabolic process D5 201 Q4V7C6 14 GMP synthase 76709 6.21 0.464 0.029 1.6E-05 D27 103 Q3SWU3 2 Heterogeneous nuclear ribonucleoprotein D-like 35272 9.14 0.710 0.007 6.2E-09 D30 165 Q3SWU3 5 Heterogeneous nuclear ribonucleoprotein D-like 35272...”
2e18A / O57921 Crystal structure of project ph0182 from pyrococcus horikoshii ot3
26% identity, 39% coverage
XP_011511565 GMP synthase [glutamine-hydrolyzing] isoform X1 from Homo sapiens
34% identity, 10% coverage
- Guanosine monophosphate synthase upregulation mediates cervical cancer progression by inhibiting the apoptosis of cervical cancer cells via the Stat3/P53 pathway.
Wang, International journal of oncology 2021 - GeneRIF: Guanosine monophosphate synthase upregulation mediates cervical cancer progression by inhibiting the apoptosis of cervical cancer cells via the Stat3/P53 pathway.
- The upregulated expression of RFC4 and GMPS mediated by DNA copy number alteration is associated with the early diagnosis and immune escape of ESCC based on a bioinformatic analysis.
Wang, Aging 2021 - GeneRIF: The upregulated expression of RFC4 and GMPS mediated by DNA copy number alteration is associated with the early diagnosis and immune escape of ESCC based on a bioinformatic analysis.
- Interactions of GMP with Human Glrx3 and with Saccharomyces cerevisiae Grx3 and Grx4 Converge in the Regulation of the Gcn2 Pathway.
Mechoud, Applied and environmental microbiology 2020 - GeneRIF: Interactions of GMP with Human Glrx3 and with Saccharomyces cerevisiae Grx3 and Grx4 Converge in the Regulation of the Gcn2 Pathway.
- Nonsynonymous Polymorphism in Guanine Monophosphate Synthetase Is a Risk Factor for Unfavorable Thiopurine Metabolite Ratios in Patients With Inflammatory Bowel Disease.
Roberts, Inflammatory bowel diseases 2018 (PubMed)- GeneRIF: The GMPS SNP rs61750370 may be a reliable risk factor for extreme 6MMP preferential metabolism in patients with inflammatory bowel disease
- Methylation and expression analyses of Pallister-Killian syndrome reveal partial dosage compensation of tetrasomy 12p and hypomethylation of gene-poor regions on 12p.
Davidsson, Epigenetics 2016 - GeneRIF: Three genes-ATP6V1G1 in 9q32, GMPS in 3q25.31, and TBX5 in 12q24.21-exhibited concomitant hypermethylation and decreased expression. The i(12p)-positive cells displayed global hypomethylation of gene-poor regions on 12p, a footprint previously associated with constitutional and acquired gains of whole chromosomes as well as with X-chromosome inactivation in females
- Nucleotide biosynthetic enzyme GMP synthase is a TRIM21-controlled relay of p53 stabilization.
Reddy, Molecular cell 2014 (PubMed)- GeneRIF: Cytoplasmic sequestration of GMPS requires ubiquitylation by TRIM21.
- Mechanism of USP7/HAUSP activation by its C-terminal ubiquitin-like domain and allosteric regulation by GMP-synthetase.
Faesen, Molecular cell 2011 (PubMed)- GeneRIF: analysis of USP7/HAUSP activation by its C-terminal ubiquitin-like domain and allosteric regulation by GMP-synthetase
- Human variation in alcohol response is influenced by variation in neuronal signaling genes.
Joslyn, Alcoholism, clinical and experimental research 2010 (PubMed)- GeneRIF: Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
- More
GUAA_HUMAN / P49915 GMP synthase [glutamine-hydrolyzing]; GMP synthetase; Glutamine amidotransferase; EC 6.3.5.2 from Homo sapiens (Human) (see 2 papers)
P49915 GMP synthase (glutamine-hydrolysing) (EC 6.3.5.2) from Homo sapiens (see paper)
34% identity, 10% coverage
- function: Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate.
catalytic activity: XMP + L-glutamine + ATP + H2O = GMP + L-glutamate + AMP + diphosphate + 2 H(+) (RHEA:11680)
cofactor: Mg(2+)
subunit: Homodimer. - Longitudinal Assessment of Nasopharyngeal Biomarkers Post-COVID-19: Unveiling Persistent Markers and Severity Correlations.
Redondo-Calvo, Journal of proteome research 2024 - “...MK03* mitogen-activated protein kinase3 1.53 1.32 MAPK3 P27361 GUAA GMP synthase [glutamine-hydrolyzing] 2.10 1.36 GMPS P49915 HSP7E heat shock 70kDa protein 14 1.82 1.40 HSPA14 Q0VDF9 CSK21 casein kinaseII subunit alpha 1.37 1.42 CSNK2A1 P68400 CSDE1 cold shock domain-containing protein E1 1.61 1.42 CSDE1 O75534 FUBP2...”
- IgGFc-binding protein and MUC2 mucin produced by colonic goblet-like cells spatially interact non-covalently and regulate wound healing.
Gorman, Frontiers in immunology 2023 - “...GRN Granulins P28799 -0.928264785 USP5 Ubiquitin carboxyl-terminal hydrolase 5 P45974 -0.924207262 GMPS GMP synthase [glutamine-hydrolyzing] P49915 -0.919369622 PLIN3 Perilipin-3 O60664 -0.916943251 EIF2S1 Eukaryotic translation initiation factor 2 subunit 1 P05198 -0.911071446 ACAA2 3-ketoacyl-CoA thiolase, mitochondrial P42765 -0.893276481 RAB11A Ras-related protein Rab-11A;Ras-related protein Rab-11B P62491 -0.879833883 SMARCE1...”
- PATHWAYS ASSOCIATED WITH POSITIVE SEPSIS SURVIVAL OUTCOMES IN AFRICAN AMERICAN/BLACK AND NON-HISPANIC WHITE PATIENTS WITH URINARY TRACT INFECTION.
Kapp, Shock (Augusta, Ga.) 2023 - “...transfer flavoprotein subunit <0.001 0.34 0.05 Q96AC1 FERMT2 Fermitin family homolog 2 0.018 0.46 0.09 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0.048 1.01 0.23 P42357 HAL Histidine ammonia-lyase <0.001 0.36 0.06 P044392 HLA-A Isoform 2 of HLA class I histocompatibility antigen, A chain <0.001 0.67 0.12 P09651...”
- Proteomic Signatures of Human Visceral and Subcutaneous Adipocytes
Hruska, The Journal of clinical endocrinology and metabolism 2022 - “...1-like protein GPD1L -3.05 1.53E-08 P20962 Parathymosin PTMS -3.12 3.39E-05 P15311 Ezrin EZR -3.13 6.70E-07 P49915 GMP synthase [glutamine-hydrolyzing] GMPS -3.21 9.14E-14 P16050 Arachidonate 15-lipoxygenase ALOX15 -3.30 2.20E-09 Q53EU6 Glycerol-3-phosphate acyltransferase 3 AGPAT9 -3.50 9.14E-14 P20774 Mimecan OGN -3.57 6.25E-06 Q5VT79 Annexin A8-like protein 2 ANXA8L2...”
- Proteome profiling of ductal carcinoma in situ.
Mosavi, Breast disease 2022 (PubMed) - Traditional Human Populations and Nonhuman Primates Show Parallel Gut Microbiome Adaptations to Analogous Ecological Conditions.
Sharma, mSystems 2020 - “...any other group, while wet season gorilla microbiomes showed greater abundances of GMP synthase ( P49915 ) ( Fig.3d ). FIG3 Xenobiotic-degrading capabilities in the gut microbiome of gorillas across two seasons of variable dietary intake and in humans under two different subsistence strategies. (a) Principal-coordinate...”
- “...4_2), multicopper oxidases (auxiliary activity, AA1), and GH96. This cluster also showed association with XDE P49915 (GMP synthase). In SN2, Collinsella aerofaciens , which showed the greatest abundance in the agriculturalists and the gorillas during the wet season, showed coabundance patterns with genes involved in styrene...”
- O-Acetylated Chemical Reporters of Glycosylation Can Display Metabolism-Dependent Background Labeling of Proteins but Are Generally Reliable Tools for the Identification of Glycoproteins.
Darabedian, Frontiers in chemistry 2020 - “...Protein PRRC2C Q9Y520 18 [K].TV C DAAEK.[G] Perilipin-3 O60664 19 [K].TVGVQGD C R.[S] GMP synthase P49915 20 [K].VA C AEEWQESR.[T] TIP41-liked protein O75663 21 [K].VVNEINIEDL C LTK.[A] CDGSH iron-sulfur domain-containing protein Q8N5K1 22 [M].A C ARPLISVYSEK.[G] 60S ribosomal protein L4 P36578 23 [M].A C GLVASNLNLKPGECLR.[V] Galectin-1...”
- A Proteomic Approach to Uncover Neuroprotective Mechanisms of Oleocanthal against Oxidative Stress.
Giusti, International journal of molecular sciences 2018 - “...(n) Unique Coverage (%) MW (th) pI (th) Metabolism 381 Guanosine 5-monophosphate synthase (glutamine-hydrolyzing) GMPS P49915 32 32 52 76,716 6.42 521 Pyruvate kinase PKM PKM P14618 36 6 59 57,937 7.96 559 Amidophosphoribosyltransferase PPAT Q06203 4 4 10 57,398 6.3 693 Gamma-enolase ENO2 P09104 13...”
- “...subunit 1 0.76 0.026 335 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0.67 0.018 381 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0.75 0.014 430 Q14195 DPYSL3 Dihydropyrimidinase-related protein 3 0.58 0.002 436 Q14195 DPYSL3 Dihydropyrimidinase-related protein 3 0.74 0.001 441 Q14195 DPYSL3 Dihydropyrimidinase-related protein 3 1.56 0.022...”
- More
Q53F90 GMP synthase (glutamine-hydrolyzing) (Fragment) from Homo sapiens
34% identity, 10% coverage
2vxoB / P49915 Human gmp synthetase in complex with xmp (see paper)
34% identity, 11% coverage
- Ligand: xanthosine-5'-monophosphate (2vxoB)
For advice on how to use these tools together, see
Interactive tools for functional annotation of bacterial genomes.
The PaperBLAST database links 789,361 different protein sequences to 1,256,019 scientific articles. Searches against EuropePMC were last performed on January 10 2025.
PaperBLAST builds a database of protein sequences that are linked
to scientific articles. These links come from automated text searches
against the articles in EuropePMC
and from manually-curated information from GeneRIF, UniProtKB/Swiss-Prot,
BRENDA,
CAZy (as made available by dbCAN),
BioLiP,
CharProtDB,
MetaCyc,
EcoCyc,
TCDB,
REBASE,
the Fitness Browser,
and a subset of the European Nucleotide Archive with the /experiment tag.
Given this database and a protein sequence query,
PaperBLAST uses protein-protein BLAST
to find similar sequences with E < 0.001.
To build the database, we query EuropePMC with locus tags, with RefSeq protein
identifiers, and with UniProt
accessions. We obtain the locus tags from RefSeq or from MicrobesOnline. We use
queries of the form "locus_tag AND genus_name" to try to ensure that
the paper is actually discussing that gene. Because EuropePMC indexes
most recent biomedical papers, even if they are not open access, some
of the links may be to papers that you cannot read or that our
computers cannot read. We query each of these identifiers that
appears in the open access part of EuropePMC, as well as every locus
tag that appears in the 500 most-referenced genomes, so that a gene
may appear in the PaperBLAST results even though none of the papers
that mention it are open access. We also incorporate text-mined links
from EuropePMC that link open access articles to UniProt or RefSeq
identifiers. (This yields some additional links because EuropePMC
uses different heuristics for their text mining than we do.)
For every article that mentions a locus tag, a RefSeq protein
identifier, or a UniProt accession, we try to select one or two
snippets of text that refer to the protein. If we cannot get access to
the full text, we try to select a snippet from the abstract, but
unfortunately, unique identifiers such as locus tags are rarely
provided in abstracts.
PaperBLAST also incorporates manually-curated protein functions:
- Proteins from NCBI's RefSeq are included if a
GeneRIF
entry links the gene to an article in
PubMed®.
GeneRIF also provides a short summary of the article's claim about the
protein, which is shown instead of a snippet.
- Proteins from Swiss-Prot (the curated part of UniProt)
are included if the curators
identified experimental evidence for the protein's function (evidence
code ECO:0000269). For these proteins, the fields of the Swiss-Prot entry that
describe the protein's function are shown (with bold headings).
- Proteins from BRENDA,
a curated database of enzymes, are included if they are linked to a paper in PubMed
and their full sequence is known.
- Every protein from the non-redundant subset of
BioLiP,
a database
of ligand-binding sites and catalytic residues in protein structures, is included. Since BioLiP itself
does not include descriptions of the proteins, those are taken from the
Protein Data Bank.
Descriptions from PDB rely on the original submitter of the
structure and cannot be updated by others, so they may be less reliable.
(For SitesBLAST and Sites on a Tree, we use a larger subset of BioLiP so that every
ligand is represented among a group of structures with similar sequences, but for
PaperBLAST, we use the non-redundant set provided by BioLiP.)
- Every protein from EcoCyc, a curated
database of the proteins in Escherichia coli K-12, is included, regardless
of whether they are characterized or not.
- Proteins from the MetaCyc metabolic pathway database
are included if they are linked to a paper in PubMed and their full sequence is known.
- Proteins from the Transport Classification Database (TCDB)
are included if they have known substrate(s), have reference(s),
and are not described as uncharacterized or putative.
(Some of the references are not visible on the PaperBLAST web site.)
- Every protein from CharProtDB,
a database of experimentally characterized protein annotations, is included.
- Proteins from the CAZy database of carbohydrate-active enzymes
are included if they are associated with an Enzyme Classification number.
Even though CAZy does not provide links from individual protein sequences to papers,
these should all be experimentally-characterized proteins.
- Proteins from the REBASE database
of restriction enzymes are included if they have known specificity.
- Every protein with an evidence-based reannotation (based on mutant phenotypes)
in the Fitness Browser is included.
- Sequence-specific transcription factors (including sigma factors and DNA-binding response regulators)
with experimentally-determined DNA binding sites from the
PRODORIC database of gene regulation in prokaryotes.
- Putative transcription factors from RegPrecise
that have manually-curated predictions for their binding sites. These predictions are based on
conserved putative regulatory sites across genomes that contain similar transcription factors,
so PaperBLAST clusters the TFs at 70% identity and retains just one member of each cluster.
- Coding sequence (CDS) features from the
European Nucleotide Archive (ENA)
are included if the /experiment tag is set (implying that there is experimental evidence for the annotation),
the nucleotide entry links to paper(s) in PubMed,
and the nucleotide entry is from the STD data class
(implying that these are targeted annotated sequences, not from shotgun sequencing).
Also, to filter out genes whose transcription or translation was detected, but whose function
was not studied, nucleotide entries or papers with more than 25 such proteins are excluded.
Descriptions from ENA rely on the original submitter of the
sequence and cannot be updated by others, so they may be less reliable.
Except for GeneRIF and ENA,
the curated entries include a short curated
description of the protein's function.
For entries from BioLiP, the protein's function may not be known beyond binding to the ligand.
Many of these entries also link to articles in PubMed.
For more information see the
PaperBLAST paper (mSystems 2017)
or the code.
You can download PaperBLAST's database here.
Changes to PaperBLAST since the paper was written:
- November 2023: incorporated PRODORIC and RegPrecise. Many PRODORIC entries were not linked to a protein sequence (no UniProt identifier), so we added this information.
- February 2023: BioLiP changed their download format. PaperBLAST now includes their non-redundant subset. SitesBLAST and Sites on a Tree use a larger non-redundant subset that ensures that every ligand is represented within each cluster. This should ensure that every binding site is represented.
- June 2022: incorporated some coding sequences from ENA with the /experiment tag.
- March 2022: incorporated BioLiP.
- April 2020: incorporated TCDB.
- April 2019: EuropePMC now returns table entries in their search results. This has expanded PaperBLAST's database, but most of the new entries are of low relevance, and the resulting snippets are often just lists of locus tags with annotations.
- February 2018: the alignment page reports the conservation of the hit's functional sites (if available from from Swiss-Prot or UniProt)
- January 2018: incorporated BRENDA.
- December 2017: incorporated MetaCyc, CharProtDB, CAZy, REBASE, and the reannotations from the Fitness Browser.
- September 2017: EuropePMC no longer returns some table entries in their search results. This has shrunk PaperBLAST's database, but has also reduced the number of low-relevance hits.
Many of these changes are described in Interactive tools for functional annotation of bacterial genomes.
PaperBLAST cannot provide snippets for many of the papers that are
published in non-open-access journals. This limitation applies even if
the paper is marked as "free" on the publisher's web site and is
available in PubmedCentral or EuropePMC. If a journal that you publish
in is marked as "secret," please consider publishing elsewhere.
Many important articles are missing from PaperBLAST, either because
the article's full text is not in EuropePMC (as for many older
articles), or because the paper does not mention a protein identifier such as a locus tag, or because of PaperBLAST's heuristics. If you notice an
article that characterizes a protein's function but is missing from
PaperBLAST, please notify the curators at UniProt
or add an entry to GeneRIF.
Entries in either of these databases will eventually be incorporated
into PaperBLAST. Note that to add an entry to UniProt, you will need
to find the UniProt identifier for the protein. If the protein is not
already in UniProt, you can ask them to create an entry. To add an
entry to GeneRIF, you will need an NCBI Gene identifier, but
unfortunately many prokaryotic proteins in RefSeq do not have
corresponding Gene identifers.
References
PaperBLAST: Text-mining papers for information about homologs.
M. N. Price and A. P. Arkin (2017). mSystems, 10.1128/mSystems.00039-17.
Europe PMC in 2017.
M. Levchenko et al (2017). Nucleic Acids Research, 10.1093/nar/gkx1005.
Gene indexing: characterization and analysis of NLM's GeneRIFs.
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by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory