PaperBLAST
PaperBLAST Hits for SwissProt::Q5XDV5 Probable ABC transporter ATP-binding protein M6_Spy0273 (Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)) (256 a.a., MSILEINNLH...)
Show query sequence
>SwissProt::Q5XDV5 Probable ABC transporter ATP-binding protein M6_Spy0273 (Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394))
MSILEINNLHVSIEGKEILKGVNLTLKTGEVAAIMGPNGTGKSTLSAAIMGNPNYEVTQG
QILLDGVNILDLEVDERARLGLFLAMQYPSEIPGITNAEFMRAAMNAGKADEDKISVRDF
ITKLDEKMALLGMKEEMAERYLNEGFSGGEKKRNEILQLLMLEPKFALLDEIDSGLDIDA
LKVVSKGVNEMRGKDFGAMIITHYQRLLNYITPDLVHVMMDGRIVLSGDAALATRLEKEG
YAGIAQDLGIEYKEES
Running BLASTp...
Found 280 similar proteins in the literature:
Y273_STRP6 / Q5XDV5 Probable ABC transporter ATP-binding protein M6_Spy0273 from Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)
Spy49_0242 Iron-sulfur cluster assembly ATPase protein SufC from Streptococcus pyogenes NZ131
SPy0285 putative ABC transporter (ATP-binding protein) from Streptococcus pyogenes M1 GAS
100% identity, 100% coverage
- Identification of novel growth phase- and media-dependent small non-coding RNAs in Streptococcus pyogenes M49 using intergenic tiling arrays
Patenge, BMC genomics 2012 - “...sRNASpy490238 248530 248579 49 + Spy49_0238 bacA a 6 sRNASpy490241 251595 251644 49 + rgpG Spy49_0242 a 7 sRNASpy490305 318826 318910 84 + Spy49_0305 Spy49_0306 23S-methyl b 8 sRNASpy490306 319622 319776 154 + Spy49_0306 Spy49_0307 FMN RNA319780 [ 20 ] b 9 sRNASpy490348 362857 362906 49...”
- Point mutations within the streptococcal regulator of virulence (Srv) alter protein-DNA interactions and Srv function
Doern, Microbiology (Reading, England) 2008 - “...Fig. 3a ) ( Reid et al. , 2004 ). These targets are designated spy0044, spy0285, spy0714 and slr and are located upstream of their corresponding genes spy0044 (zinc-containing dehydrogenase), spy0285 (ATP-binding protein), spy0714 (zinc-binding protein AdcA) and slr (streptococcal leucine-rich protein). In previous work, real-time...”
- “...A values that were 5.90 and 3.10 fold higher than that of rSrv bound to spy0285 ( Fig. 5 ). Taken together, these data further support the hypothesis that the Srv HTH is a mediator of DNA interaction. Complementation with srv in trans restores wild-type SpeB...”
- Identification of srv, a PrfA-like regulator of group A streptococcus that influences virulence
Reid, Infection and immunity 2004 - “...L. monocytogenes high-affinity zinc binding lipoprotein (43); SPy0285, ATP binding protein (207); SPy0044, zinc-containing dehydrogenase (113); and SPy 0714,...”
- “...differences between the transcript levels of the slr, spy2007, spy0285, spy0044, and spy0714 genes may be more pronounced. To investigate if the absence of Srv...”
spyM18_0273 putative ABC transporter (ATP-binding protein) from Streptococcus pyogenes MGAS8232
100% identity, 100% coverage
WP_000114500 Fe-S cluster assembly ATPase SufC from Streptococcus agalactiae GB00640
89% identity, 100% coverage
- Adaptive response of neonatal sepsis-derived Group B Streptococcus to bilirubin
Hansen, Scientific reports 2018 - “...2627 Ornithine carbamoyltransferase (WP_000793622, arcB1) 193 42 1.341 0.024 3028 Iron ABC transporter ATP-binding protein (WP_000114500, no RefSeq gene ID) 151 35 1.217 0.032 10 significant proteins from across three GBS isolates were selected and identified by LC-MS and MUDPIT database. Gene ontology analysis was performed...”
SPD_0762 FeS assembly ATPase SufC from Streptococcus pneumoniae D39
86% identity, 100% coverage
SSA_1956 ABC-type Fe-S cluster assembly transporter, ATPase component, putative from Streptococcus sanguinis SK36
86% identity, 100% coverage
T303_02075 Fe-S cluster assembly ATPase SufC from Streptococcus thermophilus ASCC 1275
85% identity, 100% coverage
stu0164 ABC transporter ATP binding protein from Streptococcus thermophilus LMG 18311
85% identity, 96% coverage
EF2394 ABC transporter, ATP-binding protein from Enterococcus faecalis V583
EF_2394, OG1RF_11829 Fe-S cluster assembly ATPase SufC from Enterococcus faecalis V583
81% identity, 100% coverage
- Genes Contributing to the Unique Biology and Intrinsic Antibiotic Resistance of Enterococcus faecalis
Gilmore, mBio 2020 - “...100 O SAW_02255 EF2393 Important ABC Fe FeS assembly protein SufD 0.022 100 O SAW_02256 EF2394 Important ABC Fe FeS assembly ATPase SufC 0.011 100 O SAW_02382 EF2562 Potentially Important C Mo UE Flavodoxin 0.048 100 C SAW_02383 EF2563 Potentially Critical C Mo Se UE YqeB...”
- Oxidative stress enhances the expression of sulfur assimilation genes: preliminary insights on the Enterococcus faecalis iron-sulfur cluster machinery regulation
Riboldi, Memorias do Instituto Oswaldo Cruz 2014 - “...and/or oligo-dT primers (Invitrogen). E. faecalis V583 reference sequences for primer design for sufC (GenBank EF2394), sufD (EF2393), sufS (EF2392), sufU (EF2391), sufB (EF2390), kat (EF1597), fur (EF1525), oxyR (EF2958), 23S rRNA (EF23SD), elongation factor for transporter RNA ( tuf ) (EF0201), RNA polymerase beta chain...”
- Structural studies of the Enterococcus faecalis SufU [Fe-S] cluster protein
Riboldi, BMC biochemistry 2009 - “...protein, involved in donation of the sulfur molecule to the [Fe-S] cluster formation; EF3293 and EF2394 encoding SufD and SufC orthologue proteins, which presented 22% and 52% identity with the E. coli proteins, respectively. Once the phylogenetic analysis enabled the verification of high conservation and similarity...”
- Transcriptional response of Enterococcus faecalis V583 to erythromycin
Aakra, Antimicrobial agents and chemotherapy 2005 - “...EF1492 EF1673 EF1720 EF1759 EF2049 EF2050 EF2074 EF2081 EF2394 EF2647 EF2769 EF2959 EF2960 EF3106 EF3107 EF3108 EF3109 EF3110 EF3277 EF0452 EF0453 EF0678 EF0877...”
- ClpP participates in stress tolerance, biofilm formation, antimicrobial tolerance, and virulence of Enterococcus faecalis
Zheng, BMC microbiology 2020 - “...) 2,5-diketo-D-gluconate reductase 1.212 AEA94423.1 ( OG1RF_11736 ) group 2 glycosyl transferase 1.211 AEA94516.1 ( OG1RF_11829, sufC ) ABC superfamily ATP binding cassette transporter, ABC protein 1.208 AEA93609.1 ( OG1RF_10922 ) hypothetical protein 1.204 AEA93584.1 ( OG1RF_10897 ) glutamine ABC superfamily ATP binding cassette transporter, binding...”
- The Enterococcus faecalis exoproteome: identification and temporal regulation by Fsr
Shankar, PloS one 2012 - “...30.32/4.89 3/4 16 7a Hypothetical protein (EF_1470) 14.62/5.61 5/26 38 8a ABC transporter, ATP-binding protein (EF_2394) 28.40/4.73 9/13 37 9a Glycine betaine/carnitine/choline ABC transporter (EF_0863) 34.72/5.14 16/21 41 10a Fructose-bisphosphate aldolase class II, Fba (EF_1167) 31.02/4.86 7/14 26 11a Adenylate kinase (EF_0228) 24.25/5.05 9/15 36 12a...”
LLKF_1966 SUF system FeS cluster assembly protein ATP-dependent transporter SufC from Lactococcus lactis subsp. lactis KF147
78% identity, 100% coverage
- Strain-Dependent Transcriptome Signatures for Robustness in Lactococcus lactis
Dijkstra, PloS one 2016 - “...negative 0.3 LLKF_0540 uvrB excinuclease ABC subunit B positive 2.4 LLKF_1295 hypothetical protein negative 0.5 LLKF_1966 sufC SUF system FeS cluster assembly protein ATP-dependent transporter SufC positive 11.5 LLKF_0052 cysD O-acetyl-L-homoserine sulfhydrolase/O-acetyl-L-serine sulfhydrolase positive 1.8 LLKF_0904 yjaF hypothetical protein positive 5.6 LLKF_0162 ybhA 5-formyltetrahydrofolate cyclo-ligase negative...”
CG42_RS12665 Fe-S cluster assembly ATPase SufC from Listeria monocytogenes
lmo2415 similar to ABC transporter, ATP-binding protein from Listeria monocytogenes EGD-e
74% identity, 94% coverage
- Whole Genome and Core Genome Multilocus Sequence Typing and Single Nucleotide Polymorphism Analyses of Listeria monocytogenes Isolates Associated with an Outbreak Linked to Cheese, United States, 2013
Chen, Applied and environmental microbiology 2017 - “...A G Yes CG42_RS11530, xylose isomerase, lmo2160 2532881 C C A No W W L CG42_RS12665, glutamate decarboxylase, lmo2434 a The reported SNP position, protein ID, and putative functions are based on the complete and annotated chromosome of isolate CFSAN010068 (GenBank accession number NZ_CP014250.1 ). All...”
- “...17 17 122 Xylose isomerase, d CG42_RS11530 lmo2434 15 or 129 15 117 Glutamate decarboxylase, CG42_RS12665 a The locus was included in the wgMLST scheme but not in the cgMLST scheme. b In the BioNumerics allele database, numbers to designate the same alleles for CDC users...”
- Comparison of Surface Proteomes of Adherence Variants of Listeria Monocytogenes Using LC-MS/MS for Identification of Potential Surface Adhesins
Tiong, Pathogens (Basel, Switzerland) 2016 - “...and nucleic acids 2.3 --- >10 --- 23 lmo2156 lmo2156 Unknown 5.1 --- --- 24 lmo2415 * ,1 lmo2415 Transport/binding proteins and lipoproteins 1.2 --- >10 --- 25 lmo2505 1 spl Cell wall 1.1 --- 26 lmo2525 * ,1 mbl Cell wall 1.1 --- 10 ---...”
- An update on the transport and metabolism of iron in Listeria monocytogenes: the role of proteins involved in pathogenicity
Lechowicz, Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2015 - “...the sole pathway for the biosynthesis of FeS clusters and is encoded by lmo2411 - lmo2415 genes which are homologues for sufCDSUB present in other Gram-positive genera (Riboldi et al. 2009 ). Fe 2+ ions present in the cell participate also indirectly in the regulation of...”
- Identification of a peptide-pheromone that enhances Listeria monocytogenes escape from host cell vacuoles
Xayarath, PLoS pathogens 2015 - “...52.30 35 Lmo0554 Oxidoreductase 11 45.00 43 Lmo2416 Lipoprotein SecA 4 21.20 40 Group 11 Lmo2415 FeS Assembly ATPase SufC 12 55.20 29 Lmo9211 Ctcgeneral stress protein SecA2 9 62.80 23 Lmo1474 Heat shock protein GrpE 5 64.40 22 Lmo1571 6-phosphofructokinase SecA2 5 30.40 32 Lmo0223...”
- Listeria monocytogenes {sigma}B has a small core regulon and a conserved role in virulence but makes differential contributions to stress tolerance across a diverse collection of strains
Oliver, Applied and environmental microbiology 2010 - “...lmo2208 lmo2216 lmo2217 lmo2223 lmo2232 lmo2240 lmo2397 lmo2415 lmo2507 lmo2547 lmo2633 lmo2660 lmo2664 lmo2665 lmo2666 lmo2667 lmo2668 lmo2758 lmo2791...”
SERP0496 FeS assembly ATPase SufC from Staphylococcus epidermidis RP62A
72% identity, 97% coverage
OENOO_57011 ABC transporter, ATP-binding protein from Oenococcus oeni ATCC BAA-1163
72% identity, 98% coverage
- A partial proteome reference map of the wine lactic acid bacterium Oenococcus oeni ATCC BAA-1163
Mohedano, Open biology 2014 - “...ABC transporter (OENOO_65021). In addition, we identified subunits of the ABC transporters associated with iron (OENOO_57011 and OENOO_57012), cobalt (OENOO_44010) and phosphate (OENOO_58021, OENOO_58023 and OENOO_58024) metabolism. We detected three proteins, namely UTP-glucose-1-phosphate uridylyltransferase (OENOO_59028), dTDP glucose 4,6-dehydratase (OENOO_59030) and dTDP-4-dehydrorhamnose reductase (OENOO_59032), whose coding genes...”
BSU32710 sulfur mobilizing ABC protein, ATPase from Bacillus subtilis subsp. subtilis str. 168
P80866 Vegetative protein 296 from Bacillus subtilis (strain 168)
72% identity, 96% coverage
SAOUHSC_00847 ABC transporter, ATP-binding protein, putative from Staphylococcus aureus subsp. aureus NCTC 8325
Q2FZY7 ABC transporter, ATP-binding protein, putative from Staphylococcus aureus (strain NCTC 8325 / PS 47)
SA0774 hypothetical protein from Staphylococcus aureus subsp. aureus N315
NP_371366, SAV0842 ABC transporter ATP-binding protein homolog from Staphylococcus aureus subsp. aureus Mu50
SAUSA300_0818 FeS assembly ATPase SufC from Staphylococcus aureus subsp. aureus USA300_FPR3757
SACOL0914 FeS assembly ATPase SufC from Staphylococcus aureus subsp. aureus COL
71% identity, 97% coverage
- Genomic and Long-Term Transcriptomic Imprints Related to the Daptomycin Mechanism of Action Occurring in Daptomycin- and Methicillin-Resistant Staphylococcus aureus Under Daptomycin Exposure
Cafiso, Frontiers in microbiology 2020 - “...porphobilinogen-deaminase hem C related to the nitrogen-compound metabolism; in SAOUHSC_02396 Cof-like hydrolase, SAOUHSC_01055 inositol-monophosphatase, and SAOUHSC_00847 ABC transporter involved in the metabolism of phosphate-containing compounds; in SAOUHSC_00861 lipoyl-synthase lip A for the coenzyme and cofactor metabolism; and in the molybdenum cofactor biosynthesis moa A. With regard...”
- Integrated Multi-omics, Virtual Screening and Molecular Docking Analysis of Methicillin-Resistant Staphylococcus aureus USA300 for the Identification of Potential Therapeutic Targets: An In-Silico Approach
Rahman, International journal of peptide research and therapeutics 2021 - “...synthase (folC) 38 P0A0J0 RNA polymerase sigma factor SigA (sigA) 12 P0A040 Glutamine synthetase(glnA) 39 Q2FZY7 Fe-S cluster assembly ATPase SufC (sufC) 13 A8Z4T2 60kDa chaperonin GroEL (groL) 40 Q2FJ01 Teichoic acids export ATP-binding protein TagH (tagH) 14 Q5HJZ0 DNA gyrase subunit A (gyrA) 41 Q2G041...”
- The effect of skin fatty acids on Staphylococcus aureus
Neumann, Archives of microbiology 2015 - “...0.50 SA0707 Hypothetical protein 3.06 SA0730 Pgm Phosphoglyceromutase 0.30 SA0755 Organic hydroperoxide resistance protein-like 2.34 SA0774 Hypothetical protein 0.34 SA0793 DltA d -alanine-poly(phosphoribitol) ligase subunit 1 0.40 SA0842 FabH FabH, 3-oxoacyl-(acyl carrier protein) synthase homologue 0.40 SA0843 Fab 3-oxoacyl-synthase 0.44 SA0869 FabI Enoyl-(acyl carrier protein) reductase...”
- An RpoB mutation confers dual heteroresistance to daptomycin and vancomycin in Staphylococcus aureus
Cui, Antimicrobial agents and chemotherapy 2010 - “...0.48 0.65 0.44 0.43 Nitrogen metabolism SA0008 SA0171 SA0774 SA0775 SA0776 SA0777 SA0778 SA0779 SA0819 SA1241 SA1310 Gene hutH fdh sufB gudB Phylloquinone...”
- Proteome Analyses of Staphylococcus aureus Biofilm at Elevated Levels of NaCl
Islam, Clinical microbiology (Los Angeles, Calif.) 2015 - “...5.0/43 60 NP_371297 912 ABC transporter ATP-binding protein/SAV0842 Post-translational modification, protein turnover 216 4.7/28 76 NP_371366 955 3-oxoacyl-(acyl-carrier protein) reductase/fabG Fatty acid biosynthesis 220 5.5/26 69 NP_371755 967 Hypothetical protein/SAV1067 Nucleotide transport and metabolism 120 4.6/10 98 NP_371591 1014 Universal stress protein family/SAV1710 Cellular processes and...”
- Oxidative stress is intrinsic to staphylococcal adaptation to fatty acid synthesis antibiotics
Wongdontree, iScience 2024 - “...Strains USA300 (WT) or mutant derivatives katA SAUSA300_1232, perR SAUSA300_1842, or sufD intergenic between sufC (SAUSA300_0818) and sufD (SAUSA300_0819), at position 898566, 17 , 18 are used. b Oxidizing agents were added only to SerFA precultures: H 2 O 2 , 0.5mM; phenazine-methosulfate (PMS), 20 (n=...”
- “...Nebraska Library https://doi.org/10.1128/mBio.00537-12 Transposon insertions in USA300 FPR3757 SAUSA300_0658 ( ccpE ) position 898566 between SAUSA300_0818 ( sufC ) and SAUSA300_0819 ( sufD ) SAUSA300_1232 ( katA ) SAUSA300_1542 ( hrcA ) SAUSA300_1708 ( rot ) SAUSA300_1797 ( xdrA ) SAUSA300_1842 ( perR ) SAUSA300_2037 (...”
- Virulence and Metabolism
Richardson, Microbiology spectrum 2019 (secret) - Aureolib - a proteome signature library: towards an understanding of staphylococcus aureus pathophysiology
Fuchs, PloS one 2013 - “...present study revealed an increased expression of all members of the SACOL0917 encoding operon ( SACOL0914 , SACOL0915 , SACOL0916 , SACOL0917 , and SACOL0918 ) ( http://www.aureolib.de/?m10 ), demonstrating the power of this integrative approach. In B. subtilis , a homologous system is involved in...”
- A defect in menadione biosynthesis induces global changes in gene expression in Staphylococcus aureus
Kohler, Journal of bacteriology 2008 - “...protein; SACOL0660, alcohol dehydrogenase, zinc containing; SACOL0914, FeS assembly ATPase SufC; SACOL0916, cysteine desulfurase, SufS subfamily; SACOL0931,...”
BC4983 ABC transporter ATP-binding protein from Bacillus cereus ATCC 14579
71% identity, 96% coverage
- The PlcR virulence regulon of Bacillus cereus
Gohar, PloS one 2008 - “...microarray analysis, either at t 0 (BC4986) or at t 2 (BC0069, BC1736, BC3520, BC4982, BC4983). 10.1371/journal.pone.0002793.g001 Figure 1 plcR-wt expression ratios as determined by microarray experiments. Ratios of expression between the wildtype strain and the delta plcR strain as determined by microarrays. The log2 of...”
lp_1468 ABC transporter, ATP-binding protein from Lactobacillus plantarum WCFS1
69% identity, 95% coverage
Dgeo_0474 FeS assembly ATPase SufC from Deinococcus geothermalis DSM 11300
60% identity, 95% coverage
DR2107 ABC transporter, ATP-binding protein, Ycf16 family from Deinococcus radiodurans R1
59% identity, 95% coverage
TTHA1838 SufC protein (ATP-binding protein) from Thermus thermophilus HB8
61% identity, 97% coverage
- Determination and Dissection of DNA-Binding Specificity for the Thermus thermophilus HB8 Transcriptional Regulator TTHB099
Moncja, International journal of molecular sciences 2020 - “...Histidine Kinase +0.369 2.46 10 1 S TTHA1836 Isocitrate lyase +4.423 1.52 10 4 1 TTHA1838 SufC protein, ATP-binding protein 2.465 1.06 10 3 2 TTHA1839 SufB protein, membrane protein 2.593 9.53 10 4 3 TTHA1840 SufD protein, membrane protein 2.630 6.25 10 4 4 TTHA1841...”
- Lysine propionylation is a prevalent post-translational modification in Thermus thermophilus
Okanishi, Molecular & cellular proteomics : MCP 2014 - “...TTHA0593 TTHA1300 TTHA1482 TTHA1625 TTHA1635 TTHA1714 TTHA1838 TTHA1840 TTHB162 TTHB190 Transcription TTHA0008 TTHA0101 TTHA0248 TTHA0701 TTHA1664 TTHA1812...”
- “...TTHA1028, Spot Nos. 180 and 181; TTHA1535, Spot No. 47; TTHA1838, Spot No. 150; TTHA1839, Spot Nos. 24 and 25; TTHA1840, Spot Nos. 60 and 61. DISCUSSION Lysine...”
2d2fA / Q5SH92 Crystal structure of atypical cytoplasmic abc-atpase sufc from thermus thermophilus hb8 (see paper)
61% identity, 96% coverage
- Ligands: magnesium ion; adenosine-5'-diphosphate (2d2fA)
PG0258 ABC transporter, ATP-binding protein from Porphyromonas gingivalis W83
55% identity, 96% coverage
- Role of sodium in the RprY-dependent stress response in Porphyromonas gingivalis
Krishnan, PloS one 2013 - “...0.65 0.0806 8 1.91 0.0041 8 PG0209 Formate-nitrite transporter 3.71 0.0004 12 3.39 0.0241 11 PG0258 ABC transporter, ATP-binding protein 1.78 0.0028 12 3.94 0.0000 12 PG0275 Thioredoxin family protein 1.71 0.0049 12 4.09 0.0000 12 PG0432 NOL1-NOP2-sun family protein 2.82 0.0517 12 3.58 0.0001 12...”
- Oxidative stress induces phosphorylation of the ABC transporter, ATP-binding protein, in Porphyromonas gingivalis
Toyoda, Journal of oral science 2010 (PubMed)- “...in phosphorylation of the ABC transporter, ATP-binding protein (PG0258). Since the ABC transporter family is known to be involved in lipopolysaccharide (LPS)...”
- “...successfully identified as the ABC transporter, ATPbinding protein (PG0258), with a high probability score. Matched peptides are shown in Fig. 3C. Since the ABC...”
- Adaptation of Porphyromonas gingivalis to microaerophilic conditions involves increased consumption of formate and reduced utilization of lactate
Lewis, Microbiology (Reading, England) 2009 - “...24 24 24 PG2009 PG1042 PG0299 PG0090 PG1542 PG0258 PG0095 PG0720 PG0993 PG1501 PG1505 PG0017 PG0620 PG0273 PG1540 PG1089 PG0740 PG1036 PG1638 0.701519 0.689485...”
- Porphyromonas gingivalis genes involved in community development with Streptococcus gordonii
Simionato, Infection and immunity 2006 - “...F R CTCAATGACATCGCAGGCAAGG AGCCGCCGTAGCAGGATTTG 150 PG0258 F R GCGAGAGAAGCGTGCCATTGTG TTTACCCCGCCTGCTACGATGC 195 PG0273 F R CCCTCACGATACTCCGCAAATC...”
- “...California, Berkeley PG0026 PG0047 PG0064 PG0082 PG0083 PG0104 PG0258 PG0273 PG0275 PG0432 PG0434 PG0491 PG0514 PG0548 PG0620 PG0665 PG0686 PG0699 PG0707 PG0788...”
PGN_0358 putative ABC transporter ATP-binding protein from Porphyromonas gingivalis ATCC 33277
55% identity, 96% coverage
- Insights into Dynamic Polymicrobial Synergy Revealed by Time-Coursed RNA-Seq
Hendrickson, Frontiers in microbiology 2017 - “...PGN_0937 PGN_1639 PGN_1326 PGN_0273 PGN_0937 PGN_0927 PGN_0183 fimC PGN_0931 PGN_1535 PGN_1507 PGN_1816 PGN_1534 PGN_0778 porT PGN_0358 sufC PGN_0043 PGN_1238 PGN_0185 fimE PGN_0932 PGN_1817 PGN_1204 PGN_0043 PGN_0180 fimA PGN_0458 PGN_0937 PGN_1903 PGN_0423 PGN_1460 PGN_1687 PGN_0982 PGN_1817 PGN_0752 PGN_0826 PGN_2009 PGN_0928 PGN_1210 PGN_1752 PGN_0778 porT PGN_0856 PGN_1534 PGN_0928...”
- “...PGN_1424 PGN_0549 PGN_1823 PGN_0778 porT PGN_0927 PGN_0855 PGN_0412 PGN_1821 PGN_0043 PGN_0982 PGN_1705 PGN_1674 PGN_1673 PGN_0336 PGN_0358 sufC PGN_0928 PGN_1505 PGN_1837 PGN_1211 PGN_1988 PGN_0380 PGN_1461 PGN_1906 hagC PGN_1376 PGN_1480 PGN_0739 PGN_1402 PGN_1904 hagB PGN_1340 PGN_0972 TPR motif PGN_0569 PGN_2050 PGN_0185 fimE PGN_1903 PGN_0172 PGN_1423 PGN_1673 PGN_0580 PGN_1413...”
AMUC_RS02675 Fe-S cluster assembly ATPase SufC from Akkermansia muciniphila ATCC BAA-835
57% identity, 93% coverage
- The effect of bile acids on the growth and global gene expression profiles in Akkermansia muciniphila
Hagi, Applied microbiology and biotechnology 2020 - “...WP_012419539.1 AMUC_RS02010 0.735 1.06E48 gene400 Hypothetical protein WP_042447573.1 AMUC_RS05195 0.716 2.85E13 gene1037 Hypothetical protein WP_051729423.1 AMUC_RS02675 0.716 3.12E25 gene533 Fe-S cluster assembly ATPase SufC WP_035196050.1 AMUC_RS11880 0.704 1.29E10 gene875 Hypothetical protein WP_052294442.1 AMUC_RS05795 0.701 1.23E12 gene1153 23S rRNA (guanosine(2251)-2-O)-methyltransferase RlmB WP_012420121.1 AMUC_RS09135 0.692 2.57E17 gene1819 Recombinase...”
cg1762 Iron-regulated ABC transporter ATPase subunit from Corynebacterium glutamicum ATCC 13032
55% identity, 94% coverage
- Functional Genomics Uncovers Pleiotropic Role of Rhomboids in Corynebacterium glutamicum
Luenenschloss, Frontiers in microbiology 2022 - “...at 30 and 40C. Subunits of an ABC-type transport system involved in Fe-S cluster assembly (Cg1762 and Cg1763) were more abundant in the MF at 30 and 40C. Thus, elevated proteolysis seems to occur in the deletion strain. Inorganic Ion Transport and Metabolism Apparently, ferric ion...”
- Characterization of the dicarboxylate transporter DctA in Corynebacterium glutamicum
Youn, Journal of bacteriology 2009 - “...(corrin/ porphyrin) methyltransferase cg1589 Putative secreted protein cg1762 Iron-regulated ABC transporter; ATPase subunit cg1770 DNA or RNA helicase of...”
- Acetohydroxyacid synthase, a novel target for improvement of L-lysine production by Corynebacterium glutamicum
Blombach, Applied and environmental microbiology 2009 - “...repressor Iron metabolism cg0771 cg0924 cg0926 cg0927 cg0928 cg1762 cg1763 0.34 0.20 0.39 0.29 0.37 0.46 0.35 sufC sufD cg1764 0.35 sufB cg2445 cg3404...”
- Functional genomics of pH homeostasis in Corynebacterium glutamicum revealed novel links between pH response, oxidative stress, iron homeostasis and methionine synthesis
Follmann, BMC genomics 2009 - “...0 0.44 1.47 2.3 2.0 3.2 -0.4 - - - - - SufR, SigM 24 cg1762 x sufC Suf related ABC-type transporter, ATPase component 0 0.81 1.51 3.7 3.4 4.6 3.4 4.4 4.1 0.1 2.9 2.1 SufR, SigM 25 cg1764 x sufB Suf related ABC-type transporter...”
- The extracytoplasmic function-type sigma factor SigM of Corynebacterium glutamicum ATCC 13032 is involved in transcription of disulfide stress-related genes
Nakunst, Journal of bacteriology 2007 - “...California, Berkeley Disulfide stress-related genes cg1765 cg1764 cg1763 cg1762 cg1761 cg1760 cg1759 cg3299 cg3422 cg3423 cg3424 m valuea Gene VOL. 189, 2007...”
FTL_1229 ABC transporter, ATP-binding protein from Francisella tularensis subsp. holarctica
FTH_1206 ABC superfamily ATP binding cassette transporter, ABC protein from Francisella tularensis subsp. holarctica OSU18
56% identity, 95% coverage
- Elucidation of a mechanism of oxidative stress regulation in Francisella tularensis live vaccine strain
Ma, Molecular microbiology 2016 - “...G family protein (FTL_0768), the transcription factor NusA (FTL_1810), the ABC transporter ATP binding protein (FTL_1229) and Sigma 54 modulation protein (FTL_1179) ( Fig. 6B ). A number of hypothetical proteins, ribosomal proteins, and proteins involved in metabolism were also produced at higher levels in the...”
- Hfq, a novel pleiotropic regulator of virulence-associated genes in Francisella tularensis
Meibom, Infection and immunity 2009 - “...FTL_1106 FTL_1108 FTL_1174 FTL_1177 FTL_1190 FTL_1228 FTL_1229 FTL_1230 FTL_1261 FTL_1262 FTL_1266 FTL_1267 FTL_1271 FTL_1273 FTL_1274 FTL_1275 FTL_1276...”
- Multimethodological approach to identification of glycoproteins from the proteome of Francisella tularensis, an intracellular microorganism
Balonova, Journal of proteome research 2010 - “...and 1 protein was recognized by PNA. An overlap of 4 proteins, namely FTH_1293, FTH_1598, FTH_1206, and FTH_1721, isolated by more than one lectin was observed. Moreover, the multiply-charged variants of the proteins FTH_1293, FTH_0159, FTH_0539, FTH_1598, FTH_1112, FTH_0311, FTH_0941, and FTH_1167 were detected, suggesting the...”
- “...5.78 2 - cyt - 13 FTH_0738 SNA 24.6 5.61 0 - ? - 14 FTH_1206 SNA 27.4 5.80 1 - ? - 15,16 FTH_1598 SNA MAA DSA 36.1 6.48 2 DRN 193 NT ? - 17 FTH_1855 SNA 33.7 5.46 2 - ? SPI 18,29...”
CE_RS08390 Fe-S cluster assembly ATPase SufC from Corynebacterium efficiens YS-314
55% identity, 94% coverage
MAB_2747c Probable conserved ABC transporter, ATP-binding protein from Mycobacterium abscessus ATCC 19977
55% identity, 97% coverage
Bd0187 Iron-regulated ABC transporter ATPase subunit SufC from Bdellovibrio bacteriovorus HD100
55% identity, 94% coverage
XAC2936 ABC transporter ATP-binding protein from Xanthomonas axonopodis pv. citri str. 306
57% identity, 93% coverage
DIP1293 Putative ABC transport system, ATP-binding subunit from Corynebacterium diphtheriae NCTC 13129
54% identity, 94% coverage
A9WT29 FeS assembly ATPase from Renibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235)
56% identity, 94% coverage
P51241 Probable ATP-dependent transporter ycf16 from Porphyra purpurea
55% identity, 95% coverage
SMc00531 PUTATIVE ABC TRANSPORTER ATP-BINDING PROTEIN from Sinorhizobium meliloti 1021
55% identity, 95% coverage
- Role of the regulatory gene rirA in the transcriptional response of Sinorhizobium meliloti to iron limitation
Chao, Applied and environmental microbiology 2005 - “...For instance, a cluster of genes (SMc00530, SMc00531, SMc00532, SMc00533, SMc00302, and SMc00301), including a putative nifS gene, was derepressed in...”
- “...annotation showed that the products of SMc00301, SMc00530, SMc00531, SMc00532, and SMc00533 exhibited homology to the E. coli SufA, SufB, SufC, SufD, and SufS...”
Teth39_0116 FeS assembly ATPase SufC from Thermoanaerobacter ethanolicus ATCC 33223
55% identity, 94% coverage
Q82UN3 Iron-regulated ABC transporter ATPase subunit SufC from Nitrosomonas europaea (strain ATCC 19718 / CIP 103999 / KCTC 2705 / NBRC 14298)
54% identity, 92% coverage
- Metabolic and Proteomic Responses to Salinity in Synthetic Nitrifying Communities of Nitrosomonas spp. and Nitrobacter spp
Ilgrande, Frontiers in microbiology 2018 - “...Proteins with a lower abundance were identified as a iron-regulated ABC transporter ATPase subunit SufC (Q82UN3, 1.6 times lower), a TonB-dependent receptor protein (Q82WN2, 1.8 times lower) and an acriflavin resistance protein:Heavy metal efflux pump CzcA (Q820R6, 1.9 times lower). In addition to the regulation of...”
- “...Several proteins associated to inorganic ion exchange (Protein ID: Q82TE6, Q82T81, Q82VH5, Q820R6, A0A136MUM4, Q82WN2, Q82UN3) were found to be significantly different at 30 mS cm -1 , indicating that the N. europaea deploys a different regulation of the ion and solutes exchange with its environment...”
slr0075 ABC transporter subunit from Synechocystis sp. PCC 6803
56% identity, 94% coverage
- Iron-Sulfur Cluster Biogenesis and Iron Homeostasis in Cyanobacteria
Gao, Frontiers in microbiology 2020 - “...Fe-S cluster assembly scaffold Lethal Balasubramanian et al., 2006 ; Zang et al., 2017 SufC slr0075 Fe-S cluster assembly component, provide energy Lethal Balasubramanian et al., 2006 ; Zang et al., 2017 SufD slr0076 Fe-S cluster assembly component Lethal Balasubramanian et al., 2006 ; Zang et...”
- Regulation of Iron Homeostasis and Use in Chloroplasts
Kroh, International journal of molecular sciences 2020 - “...AT4G04770 Cre15.g643600.t1.2 [ 128 ] slr0074 [ 128 ] SUFC AT3G10670 Cre07.g339700.t1.2 [ 128 ] slr0075 [ 128 ] SUFD AT5G44316 Cre12.g513950.t1.2 * [ 128 ] slr0076 [ 128 ] SUFS AT1G08490 Cre12.g525650.t1.2 [ 128 ] slr0077 [ 128 ] SUFE AT4G26500 Cre06.g309717.t1.1 [ 128 ]...”
- Finding novel relationships with integrated gene-gene association network analysis of Synechocystis sp. PCC 6803 using species-independent text-mining
Kreula, PeerJ 2018 - “...cluster metabolism sll0088 sufR hypothetical protein (transcriptional regulator, suf ) slr0074 sufB ABC transporter subunit slr0075 sufC ABC transporter ATP-binding protein slr0076 sufD hypothetical protein (FeS assembly protein) slr0077 sufS/nifS cysteine desulfurase slr1417 sufA hypothetical protein YCF57 (FeS assembly protein) Alkane biosynthesis sll0209 aar acyl-ACP reductase...”
- Comparative analysis of the primary transcriptome of Synechocystis sp. PCC 6803
Kopf, DNA research : an international journal for rapid publication of reports on genes and genomes 2014 - “...substrate-binding protein TU288 ga 26,880 8.4 slr1295 Iron transport protein TU3030 ga 59,402 8.3 slr0074, slr0075, slr0076, slr0077 ABC transporter subunit | ABC transporter ATP-binding protein | HP | cysteine desulphurase TU19 g 3,311 8.3 slr1316 Iron(III) dicitrate ABC transporter permease TU3083 ga 5,331 6.7 sll0477,...”
- Global transcriptional profiles of the copper responses in the cyanobacterium Synechocystis sp. PCC 6803
Giner-Lamia, PloS one 2014 - “...Probable ABC transporter, periplasmic binding protein Fe-S cluster response slr0077 sufS 14.92 Probable cysteine desulfurase slr0075 sufC 13.11 ABC transporter ATP-binding protein slr0076 sufD 11.16 slr0074 sufB 9.28 ABC transporter unit sll0088 sufR 8.41 slr1419 sufE 3.98 slr1846 grxC 3.25 Glutaredoxin C sll1112 aroQ 4.82 3-dehydroquinate...”
- Genome analysis of Chlamydomonas reinhardtii reveals the existence of multiple, compartmentalized iron-sulfur protein assembly machineries of different evolutionary origins
Godman, Genetics 2008 - “...Isu1, -2 S. cerevisiae Isa1, -2 Slr1417 Slr0074 Slr0075 Slr0076 Slr1419 Slr0387 Synechocystis IscA IscU IscS E. coli Orthologs of Fe-S cluster assembly proteins...”
- Regulatory roles for IscA and SufA in iron homeostasis and redox stress responses in the cyanobacterium Synechococcus sp. strain PCC 7002
Balasubramanian, Journal of bacteriology 2006 - “...SufC SufD SufS SufE sll0088 slr1417 slr0074 slr0075 slr0076 slr0077 slr1419 Regulatory repressor Assembly scaffold ABC transporter? ATPase? Iron mobilization?...”
- Response to oxidative stress involves a novel peroxiredoxin gene in the unicellular cyanobacterium Synechocystis sp. PCC 6803
Kobayashi, Plant & cell physiology 2004 (PubMed)- “...by DNA microarray. The ORFs sll1621, slr1738, slr0074, slr0075, and slr0589 were significantly induced by treatment of methyl viologen for 15 min commonly under...”
- “...many other genes including slr0589 but not slr0074 or slr0075 were derepressed to lesser extent in the mutant. Genetic disruption of sll1621, which encodes a...”
- More
MAE_RS10060 Fe-S cluster assembly ATPase SufC from Microcystis aeruginosa NIES-843
56% identity, 93% coverage
- FurA-Dependent Microcystin Synthesis under Copper Stress in Microcystis aeruginosa
Chen, Microorganisms 2020 - “...protein 1.3806 10 13 MAE_RS21970 4Fe-4S ferredoxin 1.6106 10 8 MAE_RS24290 zinc/iron-chelating domain-containing protein 0.0035634 MAE_RS10060 ABC transporter ATP-binding protein 0.0020487 MAE_RS15100 glycine cleavage system protein T 0.0011042 Iron MAE_RS00530 ferredoxin 0.0002315 MAE_RS00890 ferredoxin 0.00014744 MAE_RS06385 ferredoxin 1.1706 10 8 MAE_RS04240 ferrochelatase 0.00043992 MAE_RS05555 ferredoxin--NADP(+) reductase...”
RLV_4846 Fe-S cluster assembly ATPase SufC from Rhizobium leguminosarum bv. viciae
55% identity, 95% coverage
SYNW0320 ABC transporter, ATP-binding component from Synechococcus sp. WH 8102
51% identity, 82% coverage
AFA2_00636 Fe-S cluster assembly ATPase SufC from Alcaligenes faecalis subsp. faecalis NBRC 13111
52% identity, 97% coverage
Mb1498 PROBABLE CONSERVED ATP-BINDING PROTEIN ABC TRANSPORTER from Mycobacterium bovis AF2122/97
Rv1463 PROBABLE CONSERVED ATP-BINDING PROTEIN ABC TRANSPORTER from Mycobacterium tuberculosis H37Rv
54% identity, 91% coverage
- Comparing recombinant MPB70/SahH and native 20-kDa protein for detecting bovine tuberculosis using ELISA
Cho, The Journal of veterinary medical science 2020 - “...in a previous study [ 20 ]. The ELISA sensitivities of PC (MPB83, MPB70, Rv2650c, Mb1498, SerS), DID38 (MPB70, MPB83), and DID65 (MPB70, PstS1, CFP10) were 90.5%, 85.1%, and 81.1%, respectively, and the specificities were 98.1%, 99.1%, and 98.2%, respectively, in a previous study [ 23...”
- Transcriptomic responses to antibiotic exposure in <i>Mycobacterium tuberculosis</i>
Poonawala, Antimicrobial agents and chemotherapy 2024 (secret) - Genome mining of Mycobacterium tuberculosis: targeting SufD as a novel drug candidate through in silico characterization and inhibitor screening
Gorityala, Frontiers in microbiology 2024 - “...named suf operon. This operon encodes seven contiguous genes Rv1460 (sufR), Rv1461 (sufB), Rv1462 (sufD), Rv1463 (sufC), Rv1464 (sufS), Rv1465 (sufU), and Rv1466 (sufT) ( Huet et al., 2005 ; Pandey et al., 2018 ). FeS cluster assembly occurs in two main stages: First, assembly of...”
- “...necessary for FeS cluster assembly ( Rv1461, Rv1462 ) and ATP binding ABC transporter ( Rv1463 ). Previous research has demonstrated SufDs pivotal role in iron acquisition in E. coli ( Saini et al., 2010 ). Building on these findings, we propose the hypothesis that in...”
- B Cell and Antibody Responses in Bovine Tuberculosis
Klepp, Antibodies (Basel, Switzerland) 2024 - “...subsequently yielded higher sensitivity (90.5%) by using a higher number of antigens (MPB70, MPB83, Rv2650c, Rv1463, and Rv3834c) [ 73 ] ( Table S1 ). Another version of this platform includes the detection of IgM against the fusion protein MPB70-MPB83 and IgG against the fusion protein...”
- Mycobacterium tuberculosis Gene Expression Associated With Fluoroquinolone Resistance and Efflux Pump Inhibition
van, The Journal of infectious diseases 2023 - “...Rv0655 [transport], Rv3610c [secretion], Rv3102c [transport], and Rv1463 [transport]) had significantly increased gene expression in the MIC fold change >2...”
- “...Rv3610c +1.24 .59 +2.07 <.001 Rv3102c +1.09 .93 +1.96 <.001 Rv1463 -1.13 .88 +1.74 .01 Rv2416c -1.49 .17 -1.75 .01 Rv0929 -1.59 .05 -1.63 .03 Most of the...”
- Transcriptomic profile of the most successful Mycobacterium tuberculosis strain in Aragon, the MtZ strain, during exponential and stationary growth phases
Comín, Microbiology spectrum 2023 - “...them with an unknown substrate, as Rv1435c , Rv1218c , efpA , mmpL10 , and Rv1463 , were also upregulated. Finally, in addition to those already described, other transcriptional regulators ( Rv2612c , Rv3093c , Rv0474 , Rv0196 , ethR , Rv1219c , and Rv3413c )...”
- The role of thioredoxin proteins in Mycobacterium tuberculosis probed by proteome-wide target profiling
Sugandhi, Biochemistry and biophysics reports 2023 - “...we found that Rv1465 was captured exclusively by TrxB Whereas, TrxC captured Rv1461, Rv1462 and Rv1463, which together serve as scaffold for synthesis of FeS cluster. Here both the thioredoxins displayed the specificity for their targets despite having similar modes of action. The present study suggests...”
- Structural and Biochemical Characterization of Mycobacterium tuberculosis Zinc SufU-SufS Complex
Elchennawi, Biomolecules 2023 - “...with homology to the SUF system, Rv1460( sufR ), Rv1461( sufB ), Rv1462( sufD ), Rv1463( sufC ), Rv1464( sufS ), Rv1465( sufU ), and Rv1466( sufT ) ( Figure 1 ) [ 6 , 7 ]. Among these genes, Rv1464 is predicted to be a...”
- In Silico Approach for Phytocompound-Based Drug Designing to Fight Efflux Pump-Mediated Multidrug-Resistant Mycobacterium tuberculosis
Biswas, Applied biochemistry and biotechnology 2021 - “...the bacterium [ 27 ]. Rv3000 is also a putative efflux pump [ 28 ]. Rv1463 is an efflux pump of this family but the drugs extruded are still undetermined [ 29 ]. Rv1686c and Rv1687c are also reported to belong to this family but the...”
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LIMLP_14580 Fe-S cluster assembly ATPase SufC from Leptospira interrogans serovar Manilae
54% identity, 95% coverage
XF1475 ABC transporter ATP-binding protein from Xylella fastidiosa 9a5c
53% identity, 87% coverage
MLUT_RS17270 Fe-S cluster assembly ATPase SufC from Micrococcus luteus NCTC 2665
C5CBR0 Iron-regulated ABC transporter ATPase subunit SufC from Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / CCM 169 / CCUG 5858 / IAM 1056 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230)
55% identity, 95% coverage
RERY_39460 Fe-S cluster assembly ATPase SufC from Rhodococcus erythropolis
52% identity, 92% coverage
- Genome and Proteome Analysis of Rhodococcus erythropolis MI2: Elucidation of the 4,4´-Dithiodibutyric Acid Catabolism
Khairy, PloS one 2016 - “...tag RERY_53750 showed an expression level of 2.4 in the exponential phase and the other (RERY_39460) was expressed by a ratio of 1.9 in the stationary phase. The genome of R . erythropolis strain MI2 harbours 137 putative genes coding for proteins with an ATP-binding domain...”
- “...wild type strain LSSE8-1 [ 55 ]. Accordingly, the two ABC transporter components (RERY_53750 and RERY_39460) identified in this study could be involved in the transport of DTDB into the cell, but this is speculative and requires further experiments. Cleavage of DTDB The initial enzymatic reaction...”
YPTB2312 putative ATP-dependent transporter from Yersinia pseudotuberculosis IP 32953
52% identity, 95% coverage
MSMEG_3124 FeS assembly ATPase SufC from Mycobacterium smegmatis str. MC2 155
MSMEG_3124 Fe-S cluster assembly ATPase SufC from Mycolicibacterium smegmatis MC2 155
53% identity, 96% coverage
SEN1674 putative ABC transport ATP-binding subunit from Salmonella enterica subsp. enterica serovar Enteritidis str. P125109
52% identity, 95% coverage
A0T0E5 Iron-sulfur cluster formation ABC transporter ATP-binding subunit from Phaeodactylum tricornutum (strain CCAP 1055/1)
52% identity, 93% coverage
STM1371 putative ABC superfamily (atp_bind) transport protein from Salmonella typhimurium LT2
52% identity, 95% coverage
DW34_RS14455 Fe-S cluster assembly ATPase SufC from Yersinia pestis YN1683
YPO2402 putative ATP-dependent transporter from Yersinia pestis CO92
y1936 cysteine desulfurase ATPase component from Yersinia pestis KIM
52% identity, 95% coverage
KPNJ2_02281 Fe-S cluster assembly ATPase SufC from Klebsiella pneumoniae 30684/NJST258_2
52% identity, 95% coverage
A7MF61 ABC transporter domain-containing protein from Cronobacter sakazakii (strain ATCC BAA-894)
51% identity, 95% coverage
FRAAL4560 Transport protein associated with Fe-S cluster assembly; ATP-binding component from Frankia alni ACN14a
54% identity, 92% coverage
- The Proteogenome of Symbiotic Frankia alni in Alnus glutinosa Nodules
Pujic, Microorganisms 2022 - “...K A 0.000 WP_011604517.1 FRAAL3370 fklB Peptidylprolyl cistrans isomerase FklB 4.80 O A 0.003 WP_041939534.1 FRAAL4560 sufC FeS cluster assembly ATPase SufC 4.62 O A 0.004 WP_011603306.1 FRAAL2141 ruvB Holliday junction DNA helicase RuvB 4.60 L A 0.000 WP_011605202.1 FRAAL4072 pks Polyketide synthase 4.56 Q f...”
AM1_1223 FeS assembly ATPase SufC from Acaryochloris marina MBIC11017
50% identity, 94% coverage
- The Complex Transcriptional Response of Acaryochloris marina to Different Oxygen Levels
Hernández-Prieto, G3 (Bethesda, Md.) 2017 - “...synthetic pathway, was significantly reduced under microoxic conditions. Another group of genes ( AM1_1222 , AM1_1223 , and AM1_1224 ) in which expression was reduced under microoxic conditions, was the operon (SufBCD) coding for the proteins involved in the assembly of iron-sulfur clusters ( Shen et...”
- “...2 16 2 2.50 0.00 AM1_1222 FeS assembly protein, SufD 123 17 273 2.78 1.14 AM1_1223 FeS assembly ATPase, SufC 416 80 2067 2.36 2.31 AM1_1224 FeS assembly protein, SufB 177 30 745 2.52 2.07 AM1_5239 Copper/Zinc superoxide dismutase, SodCC 38 100 27 1.37 0.48 AM1_2962...”
Atu1823 ABC transporter, nucleotide binding/ATPase protein from Agrobacterium tumefaciens str. C58 (Cereon)
54% identity, 95% coverage
PMM0072 ABC transporter, ATP binding component from Prochlorococcus marinus sp. MED4
53% identity, 92% coverage
Bbr_0909 Fe-S cluster assembly ATPase SufC from Bifidobacterium breve UCC2003
53% identity, 93% coverage
- The essential genomic landscape of the commensal Bifidobacterium breve UCC2003
Ruiz, Scientific reports 2017 - “...clusters ( IscS, IscU, sufB, sufC, fdx , represented by locus tags Bbr_0910, Bbr_0911, Bbr_0907, Bbr_0909, Bbr_1664), which have not been previously characterized in bifidobacteria, were also found essential in our analysis. The corresponding protein complexes are known to sense oxygen and metal availability and regulate...”
MAP1189 hypothetical protein from Mycobacterium avium subsp. paratuberculosis str. k10
51% identity, 95% coverage
CCNA_01938 ATP-dependent transporter sufC from Caulobacter crescentus NA1000
CC_1862 ABC transporter, ATP-binding protein from Caulobacter crescentus CB15
56% identity, 93% coverage
- Global transcriptional response of Caulobacter crescentus to iron availability
da, BMC genomics 2013 - “...system protein 5.50 CC_1860 CCNA_01936 Cysteine desulfurase/Selenocysteine lyase 7.58 CC_1861 CCNA_01937 SufD protein 5.90 CC_1862 CCNA_01938 ATP-dependent transporter sufC 7.89 CC_1863 CCNA_01939 ADP-ribosylglycohydrolase 8.30 CC_1864 CCNA_01940 ABC transporter-associated protein sufB 7.81 CC_1865 CCNA_01941 Cysteine desulfhydrase/Selenocysteine lyase 7.09 CC_1866 b CCNA_01942 Rrf2 family transcriptional regulator 7.98 Oxidative...”
- Global transcriptional response of Caulobacter crescentus to iron availability
da, BMC genomics 2013 - “...SUF system protein 5.50 CC_1860 CCNA_01936 Cysteine desulfurase/Selenocysteine lyase 7.58 CC_1861 CCNA_01937 SufD protein 5.90 CC_1862 CCNA_01938 ATP-dependent transporter sufC 7.89 CC_1863 CCNA_01939 ADP-ribosylglycohydrolase 8.30 CC_1864 CCNA_01940 ABC transporter-associated protein sufB 7.81 CC_1865 CCNA_01941 Cysteine desulfhydrase/Selenocysteine lyase 7.09 CC_1866 b CCNA_01942 Rrf2 family transcriptional regulator 7.98...”
ECs2389 putative ATP-binding component of a transport system from Escherichia coli O157:H7 str. Sakai
52% identity, 95% coverage
ML0595 putative ABC transporter ATP-binding protein from Mycobacterium leprae TN
51% identity, 95% coverage
- Mycobacterium leprae Transcriptome During In Vivo Growth and Ex Vivo Stationary Phases
Ojo, Frontiers in cellular and infection microbiology 2021 - “...96 hr in axenic medium along with multiple ATP-binding cassette (ABC) transporters like rfbE (ML0114c), ML0595, ML0848 and ML1113c. Amino Acid Metabolism The gene expression profile of M. leprae in the MFP demonstrated that genes associated with amino acid biosynthesis pathways are transcriptionally active and quite...”
BL0870 probable ATP binding protein of ABC transporter from Bifidobacterium longum NCC2705
53% identity, 93% coverage
YnhD / b1682 Fe-S cluster scaffold complex subunit SufC from Escherichia coli K-12 substr. MG1655 (see 25 papers)
SUFC_ECOLI / P77499 Probable ATP-dependent transporter SufC from Escherichia coli (strain K12) (see 3 papers)
NP_416197 Fe-S cluster scaffold complex subunit SufC from Escherichia coli str. K-12 substr. MG1655
b1682 cysteine desulfurase ATPase component from Escherichia coli str. K-12 substr. MG1655
WP_000948863 Fe-S cluster assembly ATPase SufC from Escherichia coli
52% identity, 95% coverage
- function: Has low ATPase activity. The SufBCD complex acts synergistically with SufE to stimulate the cysteine desulfurase activity of SufS. The SufBCD complex contributes to the assembly or repair of oxygen-labile iron-sulfur clusters under oxidative stress. May facilitate iron uptake from extracellular iron chelators under iron limitation.
subunit: Part of the SufBCD complex that contains SufB, SufC and SufD. Interacts directly with SufB and SufD. Interacts with SufA (PubMed:19810706). - The Pneumococcal Protein SufC Binds to Host Plasminogen and Promotes Its Conversion into Plasmin
Yasui, Microorganisms 2023 - “...AAK33355 85.9 94.1 0.0 Staphylococcus aureus RF122 CAI80462 75.8 88.3 0.0 Escherichia coli K-12 MG1655 NP_416197 52.2 70.9 0.8...”
- SufD and SufC ATPase activity are required for iron acquisition during in vivo Fe-S cluster formation on SufB.
Saini, Biochemistry 2010 - GeneRIF: SufB, SufC, and SufD, coexpressed with the SufS-SufE sulfur transfer pair, purify as two distinct complexes (SufBC(2)D and SufB(2)C(2)) that contain Fe-S clusters and FADH(2)
- Ahp deficiency-induced redox imbalance leads to metabolic alterations in E.coli
Liu, Redox biology 2023 - “...2.63 10.64 P77667 Protein SufA 1.73 3.39 P77522 FeS cluster assembly protein SufB 1.65 5.00 P77499 Probable ATP-dependent transporter SufC 1.56 6.04 P77689 FeS cluster assembly protein SufD 1.54 6.31 P76194 Cysteine desulfuration protein SufE 1.57 1.49 P77444 Cysteine desulfurase 1.45 4.24 P0ABT2 DNA protection during...”
- A Sinorhizobium meliloti RpoH-Regulated Gene Is Involved in Iron-Sulfur Protein Metabolism and Effective Plant Symbiosis under Intrinsic Iron Limitation
Sasaki, Journal of bacteriology 2016 - “...(59%; CAC46314 and P77522) and SufC (58%; CAC46313 and P77499) between these organisms. Since SufD was shown to contribute to iron acquisition by the scaffold...”
- The Escherichia coli proteome: past, present, and future prospects
Han, Microbiology and molecular biology reviews : MMBR 2006 - “...6.16/31,613 5.73/29,525 (5-6) 5.86/28,860 (5.5-6.7) SufC P77499 Probable ATP-dependent transporter 4.84/27,582.37 Essential for replication of the chromosomes...”
- The two-component system histidine kinase EnvZ contributes to Avian pathogenic Escherichia coli pathogenicity by regulating biofilm formation and stress responses
Fu, Poultry science 2023 - “...receptor protein 2.81 b1683 sufB FeS cluster assembly protein SufB; component of SufBCD complex 2.47 b1682 sufC FeS cluster assembly ATP-binding protein; component of SufBCD complex, ATP-binding component of ABC superfamily 2.46 b1681 sufD FeS cluster scaffold complex subunit SufD 2.28 b1680 sufS L-cysteine desulfurase 1.84...”
- Medium-Chain-Length Fatty Acid Catabolism in Cupriavidus necator H16: Transcriptome Sequencing Reveals Differences from Long-Chain-Length Fatty Acid β-Oxidation and Involvement of Several Homologous Genes
Strittmatter, Applied and environmental microbiology 2023 (secret) - Ferric Citrate Uptake Is a Virulence Factor in Uropathogenic Escherichia coli
Frick-Cheng, mBio 2022 - “...5.9 b2674 phoH Phosphate starvation-inducible protein 4.1 b1020 sufC Fe-S cluster assembly ATP-binding protein 4.0 b1682 sufD Fe-S cluster assembly protein 4.1 b1681 sufE Cysteine desulfuration protein 3.8 b1679 sufS Selenocysteine lyase 4.1 b1680 tyrA Chorismate mutase 3.7 b2600 ybdZ Enterobactin biosynthesis protein 6.1 b4511 ybgS...”
- Global transcriptomic responses of Escherichia coli K-12 to volatile organic compounds
Yung, Scientific reports 2016 - “...1.14 0.33 0.16 0.71 Component of SufBCD Fe-S cluster assembly scaffold SUF b cp dms b1682 sufC 1.77 0.99 1.97 1.11 1.30 0.42 0.67 0.92 SufBCD Fe-S cluster assembly scaffold protein SUF b chp cp dma dms nmp t b1683 sufB 2.71 1.54 3.12 1.87 2.02...”
- The sulfur carrier protein TusA has a pleiotropic role in Escherichia coli that also affects molybdenum cofactor biosynthesis
Dahl, The Journal of biological chemistry 2013 - “...subunit FeS cluster biosynthesis b2527 b2528 b1679 b1680 b1681 b1682 b1683 b1684 hscB iscA sufE sufS sufD sufC sufB sufA Molecular chaperone for IscU FeS...”
- 18th Congress of the European Hematology Association, Stockholm, Sweden, June 13–16, 2013
, Haematologica 2013 - Remaining flexible in old alliances: functional plasticity in constrained mutualisms
Wernegreen, DNA and cell biology 2009 - “...secondary pathway of iron-sulfur cluster assembly sufC (ynhD) b1682 Bpen371 Bfl360 WGLp359 - - - Component of SufBCD complex sufD (ynhC) b1681 Bpen372 Bfl361...”
- Effect of RyhB small RNA on global iron use in Escherichia coli
Massé, Journal of bacteriology 2005 - “...exbB bfrc bfd feoA feoB sodA fecE b1019 b1679 b1680 b1681 b1682 b1683 b1684 b2211 b3005 b3006 b3336 b3337 b3408 b3409 b3908 b4287 1.3 1.9 7.1 2.4 2.3 3.2 1.4...”
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- Pathways of Iron and Sulfur Acquisition, Cofactor Assembly, Destination, and Storage in Diverse Archaeal Methanogens and Alkanotrophs
Johnson, Journal of bacteriology 2021 - “...10e5 (Data Set S3). Searches included queries of subunits SufB ( WP_000089364 ), SufC ( WP_000948863 ), SufD ( WP_000907979 ), SufS ( WP_000577988 ), SufU ( WP_000331707 ), SufE ( WP_001196530 ), and SufA ( WP_000367160 ) from E. coli or SufB ( AAM04369 ),...”
BMEI1041 ABC TRANSPORTER ATP-BINDING PROTEIN from Brucella melitensis 16M
53% identity, 86% coverage
- Comparative Transcriptome Analysis of Artificially Induced Rough-Mutant Brucella Strain RM57 and Its Parent Strain Brucella melitensis M1981
Peng, Frontiers in veterinary science 2019 - “...parent strain M1981 ( Figure 6 ). Among these, the highest ranked upregulated genes included BMEI1041 , BMEII0642 , BMEII1003 , BMEI1040 , BMEII0987 , BMEII0105 , BMEI1362 , BMEII0988 , BMEII0353 , and BMEII0321 while BMEI0427 , BMEI1313 , BMEI0877 , BMEII0948 , BMEII0759 ,...”
- Ontology-based Brucella vaccine literature indexing and systematic analysis of gene-vaccine association network
Hur, BMC immunology 2011 - “...putative 2 1 (0) U (2.00) BMEII1047 groES co-chaperonin GroES 1 1 (0) C (9.97) BMEI1041 sufC ABC transporter, ATP-binding protein 6 3 (2) C (9.97) BMEI2001 dnaJ chaperone protein DnaJ 1 1 (0) C (9.97) BMEI1330 htrA serine protease 7 6 (3) V P (9.76)...”
- ATP-Binding Cassette Systems of Brucella
Jenner, Comparative and functional genomics 2009 - “...ISB (ABCX) Iron/sulphur centre biogenesis CYTP BMEI1042 BruAb10940 BR0933 ISB (ABCX) Iron/sulphur centre biogenesis ABC BMEI1041 BruAb10942 BR0932 32 ISVH Iron-siderophores, VB12 and Hemin import ABC BMEI0660 BruAb11342 BR1344 BOV_1302 BCAN_A1371 ISVH Iron-siderophores, VB12 and Hemin import IM BMEI0659 BruAb11343 BR1345 BOV_1304 BCAN_A1372 ISVH Iron-siderophores, VB12...”
- “...CYTP BMEI1040 + + 31 ISB (ABCX) Iron/sulphur centre biogenesis CYTP BMEI1042 + + ABC BMEI1041 + + ABC BMEI0964 + + + 36 MKL Involved in toluene tolerance IM BMEI0965, ttg2B + + + SS BMEI0963, ttg2C + + + IM BMEII0087 + + +...”
BAB1_0949 ATP/GTP-binding site motif A (P-loop):ABC transporter:AAA ATPase from Brucella melitensis biovar Abortus 2308
53% identity, 95% coverage
BR0932 ABC transporter, ATP-binding protein from Brucella suis 1330
53% identity, 95% coverage
- ATP-Binding Cassette Systems of Brucella
Jenner, Comparative and functional genomics 2009 - “...Iron/sulphur centre biogenesis CYTP BMEI1042 BruAb10940 BR0933 ISB (ABCX) Iron/sulphur centre biogenesis ABC BMEI1041 BruAb10942 BR0932 32 ISVH Iron-siderophores, VB12 and Hemin import ABC BMEI0660 BruAb11342 BR1344 BOV_1302 BCAN_A1371 ISVH Iron-siderophores, VB12 and Hemin import IM BMEI0659 BruAb11343 BR1345 BOV_1304 BCAN_A1372 ISVH Iron-siderophores, VB12 and Hemin...”
GM298_13625 Fe-S cluster assembly ATPase SufC from Enterobacter sp. HSTU-ASh6
50% identity, 95% coverage
HVO_0859 FeS assembly ATPase SufC from Haloferax volcanii DS2
D4GUK6 Fe-S cluster assembly complex ATPase SufC from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)
46% identity, 82% coverage
- Proteomic analysis of Haloferax volcanii reveals salinity-mediated regulation of the stress response protein PspA
Bidle, Microbiology (Reading, England) 2008 - “...S7 HVO_0354 316 6 2.1 (rpsG) FeS assembly ATPase HVO_0859 439 8 2.1 (sufC) Protein of unknown HVO_1173 75 2 2.1 function, DUF127 Dihydroxyacetone kinase...”
- Genetic and proteomic analyses of a proteasome-activating nucleotidase A mutant of the haloarchaeon Haloferax volcanii
Kirkland, Journal of bacteriology 2008 - “...HVO_0581 HVO_0024 HVO_0350 HVO_0348 HVO_0861 HVO_0806 HVO_2941 HVO_0859 HVO_2700 HVO_0359 VOL. 190, 2008 ARCHAEL PROTEASE-ACTIVATING NUCLEOTIDASE A MUTANT 201...”
- Methionine Sulfoxide Reductase A (MsrA) and Its Function in Ubiquitin-Like Protein Modification in Archaea
Fu, mBio 2017 - “...chaperones 21 ND 3264 ND 8.524 K108, K169, K172, K180, K182 ( 19 ) sufC D4GUK6 Fe-S cluster assembly ATPase SufC arCOG04236 [O] posttranslational modification, protein turnover, and chaperones 33 ND 1.92.4 ND 9.014 D4GYM2 Ferritin related (IPR012347) arCOG04687 [S] function unknown 21 ND 2.43.8 ND...”
DJ66_RS00825 Fe-S cluster assembly ATPase SufC from Candidatus Liberibacter solanacearum
52% identity, 96% coverage
RSP_0437 Suf C, ATPase from Rhodobacter sphaeroides 2.4.1
55% identity, 95% coverage
- IscR of Rhodobacter sphaeroides functions as repressor of genes for iron-sulfur metabolism and represents a new type of iron-sulfur-binding protein
Remes, MicrobiologyOpen 2015 - “...in Rhodobacter sphaeroides as determined by microarray analysis RSP no. Gene log 2 FC Description RSP_0437 sufC 0.68 Suf C, ATPase RSP_0439 0.67 Hypothetical protein RSP_0440 sufB 0.67 Putative SufB RSP_0442 iscS 1.00 Putative aminotransferase RSP_0443 iscR 1.15 Rrf2 family transcriptional regulator RSP_0920 exbB 1.98 Biopolymer...”
- The sRNA SorY confers resistance during photooxidative stress by affecting a metabolite transporter in Rhodobacter sphaeroides
Adnan, RNA biology 2015 - “...DctP subunit bind prot 0.65 17.61 39 75 44 7 RSP_2401 putative 6-aminohexanoate-cyclic-dimer hydrolase 0.65 RSP_0437 sufC Suf C, ATPase 0.65 12.66 42 52 558 568 RSP_0843 Conserved protein containing sulfotransfer domain 0.62 RSP_0432 hypothetical protein 0.61 12.43 3 35 10 28 RSP_0433 hypothetical protein 0.61...”
- Role of oxygen and the OxyR protein in the response to iron limitation in Rhodobacter sphaeroides
Remes, BMC genomics 2014 - “...0.03 -0.57 -0.13 Cluster VI RSP_0434 sufD , iron-regulated ABC transporter 3.40 -1.47*** 0.40 0.69 RSP_0437 sufC, iron-regulated ABC transporter 1.75 -0.83*** -1.35 -0.66 RSP_0439 hypothetical protein 1.49 -0.76** -0.72 -0.38 RSP_0440 sufB , iron-regulated ABC transporter 2.60 -1.04* 0.01 0.44 RSP_0443 iscR, iron sulfur cluster...”
- Role of the Irr protein in the regulation of iron metabolism in Rhodobacter sphaeroides
Peuser, PloS one 2012 - “...0.70 0.90 1.01 Bacterioferritin Iron utilization RSP_0434 sufD 1.48 2.60 4.32 2.46 Fe-S cluster assembly/repair RSP_0437 sufC 1.46 2.42 4.22 1.93 Fe-S cluster assembly/repair RSP_0439 1.50 2.86 3.42 1.81 Hypothetical protein RSP_0440 sufB 1.72 2.74 3.69 1.63 Fe-S cluster assembly/repair RSP_0442 (0.74) 1.39 (3.92) 1.56 Putative...”
Hlac_0176 FeS assembly ATPase SufC from Halorubrum lacusprofundi ATCC 49239
47% identity, 81% coverage
- Morphological and proteomic analysis of biofilms from the Antarctic archaeon, Halorubrum lacusprofundi
Liao, Scientific reports 2016 - “...cysteine biosynthesis protein CysK (Hlac_1763), proteins involved in the assembly of iron-sulfur (FeS) clusters (Hlac_0175, Hlac_0176), chromosomal protein MC1 (Hlac_0021), and a predicted DNA helicase (Hlac_3022), and the lower abundance of catalase/peroxidase (HPI; Hlac_1548). Proteins that decreased in biofilms were mainly involved in protein synthesis and...”
- “...dehydrogenase, zinc-dependent 2.3 2.5 Oxidative stress Hlac_0175 FeS assembly protein SufB 1.3 ns 1.6 ns Hlac_0176 FeS assembly ATPase SufC 1.3 ns 1.5 ns Hlac_1548 catalase/peroxidase (HPI) 0.61 ns 0.50 0.50 Hlac_1677 alkyl hydroperoxide reductase (Ahp)/peroxiredoxin 1.5 ns 1.7 ns Hlac_1763 cysteine synthase A (CysK) 1.5...”
O83620 ABC transporter, ATP-binding protein from Treponema pallidum (strain Nichols)
TP0611 ABC transporter, ATP-binding protein from Treponema pallidum subsp. pallidum str. Nichols
52% identity, 94% coverage
ZMO0425 FeS assembly ATPase SufC from Zymomonas mobilis subsp. mobilis ZM4
52% identity, 93% coverage
- Model-driven analysis of mutant fitness experiments improves genome-scale metabolic models of Zymomonas mobilis ZM4
Ong, PLoS computational biology 2020 - “...MEOHtrpp_r , OGMEACPD_f , OGMEACPR_f, OGMEACPS_f, OPMEACPD_f, OPMEACPR_f, OPMEACPS_f, PMEACPE_f , S2FE2SR_f 13 ZMO0094, ZMO0423, ZMO0425, ZMO0426, ZMO0427, ZMO1067, ZMO1146, ZMO1222, ZMO1278, ZMO1692, ZMO1915, ZMO1917, ZMO1918, Biotin biosynthesis Modules with average cofitness scores below the significance threshold M45 0.497 5 E4PD_f , OHPBAT_f, PDX5PS_f, PERD_f ,...”
- Proteomic and metabolomic analysis of the cellular biomarkers related to inhibitors tolerance in Zymomonas mobilis ZM4
Chang, Biotechnology for biofuels 2018 - “...proteins involved in electron transfer, in redox and non-redox catalysis, and in gene regulation. SufC ZMO0425 and SufBD ZMO0426, which constitute the SufBCD complex that can contribute to the assembly or repair of oxygen-labile FeS clusters under oxidative stress and the uptake of iron from extracellular...”
CAC3288 Iron-regulated ABC transporter ATPase subunit (SufC), VEG296 B.subtilis ortholog from Clostridium acetobutylicum ATCC 824
50% identity, 94% coverage
- The role of PerR in O2-affected gene expression of Clostridium acetobutylicum
Hillmann, Journal of bacteriology 2009 - “...which could support the induced Suf and Nif machinery (CAC3288 to CAC3292) in the biogenesis of Fe-S clusters. Under the same conditions, a large operon...”
- “...CAC1856 CAC3276 CAC3277 CAC3358 CAC3499 Protein turnover/repair CAC1857 CAC3288 bcp fprA1 sodC trxA trxB bsaA1 bsaA2 bsaA3 nror fprA2 dfx sod rbr1 rd rbr2...”
- The transcriptional program underlying the physiology of clostridial sporulation
Jones, Genome biology 2008 - “...CAC2634, the iron permease CAC0788, feoA , feoB , fhuC , and two iron-regulated transporters (CAC3288, CAC3290), which is consistent with the earlier, more limited data [ 7 ]. Significantly, iron-limitation has been found to promote solventogenesis [ 20 ]. Solventogenesis, clostridial form, stress proteins, and...”
HQ_RS03630 ABC transporter ATP-binding protein from Haloquadratum walsbyi DSM 16790
44% identity, 80% coverage
- Differences in gene expression patterns between cultured and natural Haloquadratum walsbyi ecotypes
Rosselli, Frontiers in microbiology 2022 - “...subunit H HQ_RS09370 878 rpl29 50S ribosomal protein L29 HQ_RS05300 866 - ISH9-type transposase ISHwa1 HQ_RS03630 847 sufC Fe-S cluster assembly ATPase SufC HQ_RS08655 780 - CopG domain protein HQ_RS03635 767 sufB1 SufB domain protein HQ_RS09925 759 rps13 30S ribosomal protein S13 HQ_RS13890 755 tssA2 Thiosulfate...”
- “...population of Hqr. walsbyi HBSQ001. Gene ID TPM gene Annotation HQ_RS01075 2,380 - Uncharacterized protein HQ_RS03630 847 sufC Fe-S cluster assembly ATPase SufC HQ_RS00075 689 bop1 Bacteriorhodopsin I HQ_RS03640 601 sufB2 SufB domain protein HQ_RS03765 419 glpK Glycerol kinase HQ_RS03635 767 sufB1 SufB domain protein HQ_RS12175...”
CD16_RS04765, CLIBASIA_RS04720 Fe-S cluster assembly ATPase SufC from Candidatus Liberibacter asiaticus
CLIBASIA_04810 ABC transporter, nucleotide binding/ATPase protein from Candidatus Liberibacter asiaticus str. psy62
50% identity, 96% coverage
- Differential expression of "Candidatus Liberibacter solanacearum" genes and prophage loci in different life stages of potato psyllid
Saberi, Scientific reports 2024 - “...Liberibacter unique protein CLIBASIA_04540 DJ66_RS00995 2.00E62 AZch11 Tyrosine/serine phosphatase CLIBASIA_03975 DJ66_RS05455 2.00E74 AZch12 ABC transporter/ATPase CLIBASIA_RS04720 DJ66_RS00825 9.00E145 AZch13 Disulfide bond formation protein CLIBASIA_RS01775 DJ66_RS04250 1.00E100 AZch15 recA CLIBASIA_RS00350 DJ66_RS05900 0.00 AZch16 16S rRNA CLIBASIA_RS03560 DJ66_RS00260 0.00 Locus Predicted function/annotation wDi homolog f wBc homolog g...”
- A Significantly High Abundance of "Candidatus Liberibacter asiaticus" in Citrus Fruit Pith: in planta Transcriptome and Anatomical Analyses
Fang, Frontiers in microbiology 2021 - “...( Supplementary Table 1 ), including five ABC transporter genes (CD16_RS00210, CD16_RS00215, CD16_RS02450, CD16_RS03160, and CD16_RS04765), one glycine betaine transporter gene (CD16_RS01075), and four genes involved in the efflux pumps system (CD16_RS00510, CD16_RS03560, CD16_RS04390, and CD16_RS05425) ( Supplementary Table 1 ). The expression of genes involved...”
- Global gene expression changes in Candidatus Liberibacter asiaticus during the transmission in distinct hosts between plant and insect
Yan, Molecular plant pathology 2013 (secret) - The ABC transporters in Candidatus Liberibacter asiaticus
Li, Proteins 2012 - “...49 26 CLIBASIA_01350 PF00664 (CL0241) CLIBASIA_01355 (PP), CLIBASIA_04145 (OM) Type I protein secretion III(s) ISB CLIBASIA_04810 SufC E. coli 5e 72 56 N/A N/A N/A Fe-S assembly II ART CLIBASIA_00790 ChvD A. tumefaciens 0 77 N/A N/A N/A Virulence gene regulation II ART CLIBASIA_05125 Uup E....”
X276_17610 Fe-S cluster assembly ATPase SufC from Clostridium beijerinckii NRRL B-598
49% identity, 97% coverage
Cbei_1848 FeS assembly ATPase SufC from Clostridium beijerincki NCIMB 8052
49% identity, 97% coverage
- Transcriptional analysis of Clostridium beijerinckii NCIMB 8052 to elucidate role of furfural stress during acetone butanol ethanol fermentation
Zhang, Biotechnology for biofuels 2013 - “...furfural treatment is the iron-sulfur cluster. The expression of genes encoding iron-sulfur cluster assembly proteins (Cbei_1848, Cbei_1849, Cbei_1850, Cbei_1851 and Cbei_1852) increased by up to fivefold (Figure 1 A and Additional file 1 : Table S4A); these genes are classified into the cofactor biosynthetic process (GO:0051188)...”
- “...during solventogenesis (Figure 1 A and Additional file 1 : Table S4C), and those genes (Cbei_1848, Cbei_1849, Cbei_1850, Cbei_1851 and Cbei_1852) were up-regulated in furfural-challenged cultures by up to 54-fold compared to no more than fivefold during acidogenesis (Figure 1 A and Additional file 1 :...”
AB6I_ARATH / Q9CAF5 ABC transporter I family member 6, chloroplastic; ABC transporter ABCI.6; AtABCI6; ABC transporter ATPase; Non-intrinsic ABC protein 7; AtNAP7; Plastid SufC-like protein from Arabidopsis thaliana (Mouse-ear cress) (see paper)
AT3G10670 non-intrinsic ABC protein 7 from Arabidopsis thaliana
49% identity, 72% coverage
- function: Essential protein. Required during embryo development, especially at early stages. Involved in chloroplast differentiation.
subunit: Interacts with NAP6. - Identification of quantitative trait loci (QTLs) regulating leaf SPAD value and trichome density in mungbean (Vigna radiata L.) using genotyping-by-sequencing (GBS) approach
Kumari, PeerJ 2024 - “...digital gene expression analysis revealed that the genes AT4G25080, AT4G23940, AT5G08130, AT4G21440, AT5G47530, AT4G32360, AT2G43950, AT3G10670, AT4G18260, AT5G66940, AT1G18620 and AT5G64470 which are the orthologs of VRADIO7G29860, VRADIO7G29450, VRADIO7G17780, VRADIO7G15650, VRADI07G26610, VRADI07G28430, VRADI07G27460, VRADI07G29130, VRADI07G09390, VRADI07G10060, VRADI07G17620, and VRADI07G14170, respectively; displayed highest expression in various plant...”
- Transcriptomic and iTRAQ-Based Quantitative Proteomic Analyses of inap CMS in Brassica napus L
Wang, Plants (Basel, Switzerland) 2022 - “...2, chloroplastic 1.31 0.0001 AT3G07630 BnaC03g36730D ABC transporter I family member 6, chloroplastic 1.29 0.0458 AT3G10670 Anther and pollen development BnaAnng09150D Protein SHI RELATED SEQUENCE 5 0.74 0.0462 AT1G75520 BnaC05g00110D Squamosa promoter-binding-like protein 8 0.72 0.0031 AT4G39400 BnaC01g09870D Piriformospora indica-insensitive protein 2 0.56 0.0012 AT1G13230 BnaA07g08200D...”
- The DnaJ proteins DJA6 and DJA5 are essential for chloroplast iron-sulfur cluster biogenesis
Zhang, The EMBO journal 2021 (secret) - Occurrence, Evolution and Specificities of Iron-Sulfur Proteins and Maturation Factors in Chloroplasts from Algae
Przybyla-Toscano, International journal of molecular sciences 2021 - “...) SUFB Cre15.g643600 Scaffold protein complex At4g04770 ( SUFB ) SUFC Cre07.g339700 Scaffold protein complex At3g10670 ( SUFC ) SUFD Cre12.g513950 Scaffold protein complex At1g32500 ( SUFD ) GRX3 Cre07.g325743 Transfer protein, involved in Fe-S cluster trafficking At3g54900 ( GRXS14 ) GRX6 Cre01.g047800 At2g38270 ( GRXS16...”
- Regulation of Iron Homeostasis and Use in Chloroplasts
Kroh, International journal of molecular sciences 2020 - “...WP_010873853 Suf FeS assembly SUFB AT4G04770 Cre15.g643600.t1.2 [ 128 ] slr0074 [ 128 ] SUFC AT3G10670 Cre07.g339700.t1.2 [ 128 ] slr0075 [ 128 ] SUFD AT5G44316 Cre12.g513950.t1.2 * [ 128 ] slr0076 [ 128 ] SUFS AT1G08490 Cre12.g525650.t1.2 [ 128 ] slr0077 [ 128 ] SUFE...”
- Identifying Early Warning Signals for the Sudden Transition from Mild to Severe Tobacco Etch Disease by Dynamical Network Biomarkers
Tarazona, Viruses 2019 - “...DNB-175 is composed by genes At4g04770 ( NUCLEOSOME ASSEMBLY PROTEIN 1 , NAP1 ) and At3g10670 ( ABC TRANSPORTER I FAMILY MEMBER 6 , ABCI6 ). Both proteins belong to the ATP-binding cassette (ABC) superfamily [ 61 ]. NAP1 acts as histone chaperone functioning in cell...”
- Assembly and Transfer of Iron-Sulfur Clusters in the Plastid
Lu, Frontiers in plant science 2018 - “...; Wollers et al., 2010 ; Hu et al., 2017a , b Scaffold complex SufC At3g10670 ATPase activity; complements E. coli SufC mutant Embryo lethal Xu and Mller, 2004 ; Saini et al., 2010 ; Wollers et al., 2010 ; Hu et al., 2017a Scaffold complex...”
- Post-Transcriptional Coordination of the Arabidopsis Iron Deficiency Response is Partially Dependent on the E3 Ligases RING DOMAIN LIGASE1 (RGLG1) and RING DOMAIN LIGASE2 (RGLG2)
Pan, Molecular & cellular proteomics : MCP 2015 - “...At1g28060 At5g20320 At5g22880 At5g01770 At1g32500 At3g10670 At5g57030 At4g31560 At5g51720 At1g55140 At1g44446 At4g14890 At1g59760 At3g55460 At5g09230 At1g31280...”
- More
Bfl360 probable ATP-dependent transporter sufC from Candidatus Blochmannia floridanus
49% identity, 95% coverage
SAR11_0740 FeS assembly ATPase SufC from Candidatus Pelagibacter ubique HTCC1062
52% identity, 95% coverage
SUFC_PLAF7 / Q8ILW0 Iron-sulfur cluster assembly protein SufC; PfSufC; EC 3.6.1.- from Plasmodium falciparum (isolate 3D7) (see 4 papers)
PF3D7_1413500, XP_001348306 FeS assembly ATPase SufC from Plasmodium falciparum 3D7
45% identity, 71% coverage
- function: Participates in the sulfur mobilization (SUF) pathway for iron-sulfur (Fe-S) cluster biogenesis (PubMed:28695709). As part of a complex consisting of SufB-SufC(2)-SufD, involved in assembly of [4Fe- 4S] clusters (PubMed:28695709). Exhibits ATPase activity (PubMed:21722645, PubMed:28695709).
catalytic activity: ATP + H2O = ADP + phosphate + H(+) (RHEA:13065)
subunit: Component of a complex composed of SufB, SufC and SufD in a stoichiometric ratio of 1:2:1 (PubMed:28695709). Interacts with SufB (PubMed:21722645). Interacts with SufD; the interaction enhances the ATPase activity of SufC (PubMed:28695709).
disruption phenotype: Parasites require exogenously provided mevalonate for survival (PubMed:37166116). No significant effects on apicoplast morphology (PubMed:37166116). - The Plasmodium falciparum apicoplast cysteine desulfurase provides sulfur for both iron-sulfur cluster assembly and tRNA modification
Swift, eLife 2023 - “...Charan et al., 2017 ). SufB (PF3D7_API04700) is encoded by the apicoplast genome, while SufC (PF3D7_1413500) and SufD (PF3D7_1103400) are encoded by the nuclear genome. Dominant negative experiments with SufC suggested that the complex is essential for parasite survival ( Gisselberg et al., 2013 ), however,...”
- “...or reference Identifiers Additional information Gene ( Plasmodium falciparum ) SufC PlasmoDB ( https://plasmodb.org ) PF3D7_1413500 P. falciparum SufC gene Gene ( P. falciparum ) SufD PlasmoDB ( https://plasmodb.org ) PF3D7_1103400 P. falciparum SufD gene Gene ( P. falciparum ) SufE PlasmoDB ( https://plasmodb.org ) PF3D7_0206100...”
- Experimental Genetics of Plasmodium berghei NFU in the Apicoplast Iron-Sulfur Cluster Biogenesis Pathway
Haussig, PloS one 2013 - “...(99%) 0.9862 SUFB Sulfur mobilization scaffold protein PBANKA_API0012 PFC10_API0012 SUFC Sulfur mobilization scaffold protein PBANKA_102920 PF3D7_1413500 No SP 0/++ mito (91%) 0.5104 SUFD Sulfur mobilization, complexed withSUFB & C PBANKA_094350 PF3D7_1103400 ApicoTP ++/++ non-mito (99%) 0.5501 SUFE Desulfurase activator and sulfidetransferase PBANKA_030380 PF3D7_0206100 ApicoTP ++/++ non-mito...”
- The suf iron-sulfur cluster synthesis pathway is required for apicoplast maintenance in malaria parasites
Gisselberg, PLoS pathogens 2013 - “...Cysteine desulfurase partner SufE (PF3D7_0206100) .977 api api Non-mito (99) Scaffold SufB (PFC10_API0012) b SufC (PF3D7_1413500) .862 api Not api Mito (91) SufD (PF3D7_1103400) .93 api api Non-mito (99) Transfer SufU (PF3D7_0921400) .972 api api Non-mito (99) SufA (PF3D7_0522700) .951 api api Non-mito (99) Isc Cysteine...”
- “...[68] . The resulting transfection vector, pLN-TP-ACP-mCh, encodes mCherry instead of GFP. Constucts SufE(C154S), SufC (PF3D7_1413500) and SufC(K140A) were synthezised (GeneArt) with flanking Avr II and Bsi WI sites and inserted into a pLN plasmid modified to have a carboxy-terminal single HA tag, generating pLN-SufE(C154S)-HA, pLN-SufC-HA...”
- Interaction between sulphur mobilisation proteins SufB and SufC: evidence for an iron-sulphur cluster biogenesis pathway in the apicoplast of Plasmodium falciparum.
Kumar, International journal for parasitology 2011 (PubMed)- GeneRIF: SufB interact with SufC in the apicoplast.
SUFC_PLABA / A0A509AN56 Iron-sulfur cluster assembly protein SufC; EC 3.6.1.- from Plasmodium berghei (strain Anka) (see paper)
PBANKA_102920 ABC transporter I family member 1 from Plasmodium berghei ANKA
43% identity, 68% coverage
- function: Participates in the sulfur mobilization (SUF) pathway for iron-sulfur (Fe-S) cluster biogenesis. As part of a complex consisting of SufB-SufC(2)-SufD, involved in assembly of [4Fe-4S] clusters. Exhibits ATPase activity.
catalytic activity: ATP + H2O = ADP + phosphate + H(+) (RHEA:13065)
subunit: Component of a complex composed of SufB, SufC and SufD in a stoichiometric ratio of 1:2:1. Interacts with SufB. Interacts with SufD; the interaction enhances the ATPase activity of SufC.
disruption phenotype: Repeated attempts to isolate gene deletion mutant failed, suggesting an essential role of the gene during asexual blood stage growth. - Identification of vital and dispensable sulfur utilization factors in the Plasmodium apicoplast
Haussig, PloS one 2014 - “...). In marked contrast, we were unable to generate recombinant gene deletion parasites for SUFC (PBANKA_102920), SUFD (PBANKA_094350), SUFE (PBANKA_030380), or SUFS (PBANKA_061430) in four independent transfection experiments. In a single transfection experiment targeting SUFS , we observed integration-positive PCR products. Repeated attempts to isolate gene...”
- Experimental Genetics of Plasmodium berghei NFU in the Apicoplast Iron-Sulfur Cluster Biogenesis Pathway
Haussig, PloS one 2013 - “...non-mito (99%) 0.9862 SUFB Sulfur mobilization scaffold protein PBANKA_API0012 PFC10_API0012 SUFC Sulfur mobilization scaffold protein PBANKA_102920 PF3D7_1413500 No SP 0/++ mito (91%) 0.5104 SUFD Sulfur mobilization, complexed withSUFB & C PBANKA_094350 PF3D7_1103400 ApicoTP ++/++ non-mito (99%) 0.5501 SUFE Desulfurase activator and sulfidetransferase PBANKA_030380 PF3D7_0206100 ApicoTP ++/++...”
ST1201 248aa long hypothetical ABC transporter ATP-binding protein from Sulfolobus tokodaii str. 7
45% identity, 96% coverage
TGME49_025800 iron-sulfur assembly ATPase from Toxoplasma gondii ME49
46% identity, 47% coverage
TM1368 ABC transporter, ATP-binding protein from Thermotoga maritima MSB8
48% identity, 94% coverage
- The genus Thermotoga: recent developments
Frock, Environmental technology 2010 - “...in response to oxidative stress [ 42 ]. Other genes upregulated by oxygen exposure include TM1368, which encodes a protein involved in iron-sulfur cluster assembly and repair, as well as TM0755. The recombinant protein encoded by TM0755 was characterized as a rubredoxin oxygen oxidoreductase. This enzyme...”
- Whole-genome expression profiling of Thermotoga maritima in response to growth on sugars in a chemostat
Nguyen, Journal of bacteriology 2004 - “...atoms from cysteine to iron-sulfur clusters (Suf, TM1368 to TM1371), thiamine (ThiH), biotin (biotin synthetase, TM1269), and methionine (cystathionine...”
- Transcriptional analysis of biofilm formation processes in the anaerobic, hyperthermophilic bacterium Thermotoga maritima
Pysz, Applied and environmental microbiology 2004 - “...10.0 15.4 6.6 8.6 9.3 Iron-sulfur cluster assemblya TM1368 SufC homolog, similar to ABC ATP-binding components SufB homolog, similar to ABC permease components...”
- “...identifiable in T. maritima. The proteins encoded by sufC (TM1368) and sufB (TM1369) have been shown to interact in T. maritima cells (80); despite the lack of...”
CTLon_0054 ABC transporter ATP-binding protein from Chlamydia trachomatis L2b/UCH-1/proctitis
41% identity, 93% coverage
- Editorial: Community series - innovative approaches in diagnosis of emerging/re-emerging infectious diseases, volume II
Foster, Frontiers in microbiology 2023 - “...improve the specificity of Ch. trachomatis genotyping in Madrid. Martinez-Garcia et al. selected four genes, CTLon_0054, CTLon_0087, CTLon_0243, and CTLon_0301 , in addition to ompA , to complete the genotype analysis of Ch. trachomatis . In silico and experimental studies were performed to compare the previously...”
- Specific high-resolution scheme to improve understanding of the spatio-temporal dispersion of lymphogranuloma venereum epidemic
Martínez-García, Frontiers in microbiology 2022 - “...LGV epidemic in Madrid, Spain. Methods Four genes were selected according to their diversity index (CTLon_0054, CTLon_0087, CTLon_0243 and CTLon_0301) for use in combination with ompA . In silico and experimental studies were performed to compare the previously described multilocus sequence typing (MLST) schemes with our...”
- “...Ramn y Cajal (reference no. 012/17). In the first round, fragments of the selected genes (CTLon_0054, CTLon_0087, CTLon_0243 and CTLon_0301) together with the corresponding genes to MLST of Klint et al. (2007) , were amplified and sequenced in 28/68 samples to compare the discrimination power between...”
PAP_02345 Fe-S cluster assembly ATPase SufC from Palaeococcus pacificus DY20341
44% identity, 97% coverage
PF1287 putative ABC transporter (ATP-binding protein) from Pyrococcus furiosus DSM 3638
40% identity, 96% coverage
TON_0530 ABC-type transport system involved in Fe-S cluster assembly, ATPase component from Thermococcus onnurineus NA1
45% identity, 97% coverage
- Metabolic Adaptation to Sulfur of Hyperthermophilic Palaeococcus pacificus DY20341T from Deep-Sea Hydrothermal Sediments
Zeng, International journal of molecular sciences 2020 - “...encoding genes of ironsulfur cluster biogenesis were also upregulated including SipA (TON_0919), SipB (TON_0916), SufC (TON_0530), SufBD-related proteins (TON_0531 and TON_0849-0850), and the FeS cluster carrier protein Mrp/Nbp35 family ATP-binding protein (TON_1843) [ 10 ]. In Pa. pacificus , ABC-type iron (III)-siderophore transporter (PAP_06035-06040) and ferrous...”
- Proteomic Insights into Sulfur Metabolism in the Hydrogen-Producing Hyperthermophilic Archaeon Thermococcus onnurineus NA1
Moon, International journal of molecular sciences 2015 - “...Y Y Y Y ABC-type transport system involved in FeS cluster assembly, ATPase component (SufC) TON_0530 Y 0.92 0.85 Y 0.40 0.41 ABC-type transport system involved in FeS cluster assembly (SufBD) TON_0531 0.74 0.84 Y 0.27 0.35 Y Hypothetical protein TON_0849 (SufBD-domain containing protein) TON_0849 4.26...”
- “...in iron-sulfur cluster biogenesis were also found to be up-regulated to some extent, including SufC (TON_0530), SufBD-related proteins (TON_0531 and TON_0849-0850), and FeS cluster carrier protein Mrp/Nbp35 family ATP-binding protein (TON_1843). Such archaeal Suf proteins constitute the iron sulfur cluster assembly machinery [ 2 ]. These...”
BP1026B_I0955 Fe-S cluster assembly ATPase SufC from Burkholderia pseudomallei 1026b
38% identity, 94% coverage
- Identification of a PadR-type regulator essential for intracellular pathogenesis of Burkholderia pseudomallei
McMillan, Scientific reports 2021 - “...that are highly regulated by BP1026B_II1198 with a log 2 FC2 or-2 (Fig. 4 a). BP1026B_I0955 and BP1026B_I0956 are significantly up-regulated by BP1026B_II1198 with log 2 FCs of 2.16 and 2.03, respectively (Fig. 4 a). These genes encode putative SufC and SufB subunits of the SufBCD...”
- “...genes and pathways are important for Bp intracellular survival (Fig. 4 b,c). Transposon mutants of BP1026B_I0955, BP1026B_I1775, and BP1026B_II1506 showed the greatest decrease in intracellular survival, replicating at 61.7%, 59.3%, and 63.2% of wildtype, respectively (Fig. 4 b,c). Finally, the SCO1/SenC family protein, BP1026B_II1579, replicates at...”
- Transient In Vivo Resistance Mechanisms of Burkholderia pseudomallei to Ceftazidime and Molecular Markers for Monitoring Treatment Response
Cummings, PLoS neglected tropical diseases 2017 - “...can be found at BioProject/NCBI under submission SUB863226. qRT-PCR validation Three genes (BP1026B_II2144, BP1026B_II0025, and BP1026B_I0955) that were up or down regulated in both in vitro and in vivo ceftazidime treated conditions were selected and subjected to qRT-PCR to validate the normalized data generated from RNA-Seq...”
CAB052 Fe-S cluster assembly ATPase SufC from Chlamydia abortus S26/3
39% identity, 93% coverage
- Perceptions and Experiences of Returning Self-collected Specimens for HIV, Bacterial STI and Potential PrEP Adherence Testing among Sexual Minority Men in the United States
Sharma, AIDS and behavior 2023 - “...for me to actually get the amount that was necessary in the actual collection tube. CAB052, 31 years, non-Hispanic Black, returned all. Study Experiences with Self-collecting a Pharyngeal Swab Several participants found the process of self-collecting a pharyngeal swab as part of our study to be...”
- “...so just gotta get through it. It wasnt painful. Its not the most comfortable experience. CAB052, 31 years, non-Hispanic Black, returned all. One participant also commented that the prospect of self-collecting a rectal swab made him feel emotionally uncomfortable. Yeah, I didnt like the rectal swab,...”
MTBMA_c15330 Fe-S cluster assembly ATPase SufC from Methanothermobacter marburgensis str. Marburg
38% identity, 97% coverage
- More than 200 genes required for methane formation from H₂ and CO₂ and energy conservation are present in Methanothermobacter marburgensis and Methanothermobacter thermautotrophicus
Kaster, Archaea (Vancouver, B.C.) 2011 - “...in the genomes of M. marburgensis (MTBMA_c00690 + 00700, MTBMA_c10830 + 10840, MTBMA_c14760 + 14770, MTBMA_c15330 + 15340, MTBMA_c17570 + 17580) and M. thermautotrophicus (MTH1486 + 1487, MTH695 + 696, MTH1093 + 1094, MTH1149 + 1150, MTH1370 + 1371). 15.2. Cobalt Cobalt ions are required for...”
MTH1149 ABC transporter subunit Ycf16 from Methanothermobacter thermautotrophicus str. Delta H
37% identity, 97% coverage
MJ0035 ABC transporter subunit from Methanocaldococcus jannaschii DSM 2661
37% identity, 89% coverage
- Messenger RNA processing in Methanocaldococcus (Methanococcus) jannaschii
Zhang, RNA (New York, N.Y.) 2009 - “...MJ0217, inside the MJ0218 gene. Operons surveyed: (A) MJ0035- alignments to examine the sequences 34, iron-sulfur cluster assembly proteins SufC and SufB; (B)...”
- “...4.2- and 2.6-fold more abundant than their preceding genes (MJ0035 and MJ0113, respectively). It is also expected that the genes in a polycistronic mRNA will be...”
MMP1168 ABC transporter ATP-binding protein from Methanococcus maripaludis S2
36% identity, 93% coverage
D7DT53 ABC transporter related protein from Methanococcus voltae (strain ATCC BAA-1334 / A3)
34% identity, 93% coverage
- Proteomic Analysis of Methanococcus voltae Grown in the Presence of Mineral and Nonmineral Sources of Iron and Sulfur
Steward, Microbiology spectrum 2022 - “...Sulfur metabolism SufBD D7DT52 1.193220 1.089336 Phosphoadenosine phosphosulfate reductase D7DRD1 0.067645 0.209334 3.09454 0.0017082 SufC D7DT53 0.567117 0.401460 TCA cycle Thiamine pyrophosphate protein domain protein TPP-binding D7DUC1 1.46105 1.59608 Pyruvate flavodoxin/ferredoxin oxidoreductase domain D7DUC2 3.43884 5.41021 Acetyl-CoA carboxylase, biotin carboxylase D7DR99 0.47494 1.20170 2.53024 5.63E05 Pyruvate...”
- “...0.06359 0.01663 3.8233 0.0023623 ABC transporter-related protein D7DR50 0.23008 0.55915 2.43019 0.0003957 ABC transporter-related protein D7DT53 21.68802 15.94546 Formate/nitrite transporter D7DTM1 1.57738 1.21316 Substrate-binding region of ABC-type glycine betaine transport system D7DRC3 0.52625 0.38597 ABC transporter-related protein D7DUU7 0.10431 0.27874 2.67215 0.0057287 Glycine betaine/ l -proline...”
TM1417 ABC transporter, ATP-binding protein from Thermotoga maritima MSB8
34% identity, 90% coverage
SSO0925 ABC transporter from Sulfolobus solfataricus P2
44% identity, 59% coverage
H375_1050 LPS export ABC transporter ATP-binding protein from Rickettsia prowazekii str. Breinl
32% identity, 95% coverage
- Transcriptional profiling of Rickettsia prowazekii coding and non-coding transcripts during in vitro host-pathogen and vector-pathogen interactions
Schroeder, Ticks and tick-borne diseases 2017 - “...on four genes, namely, H375_9040 and H375_7520 (upregulated during infection of HMECs), and H375_8480 and H375_1050 (highly expressed during infection of AAE2 cells). As temperature shifts are known to alter rickettsial gene expression, total RNA preparations from HMECs infected with R. prowazekii at either 37C or...”
- “...Interestingly, H375_9040 and H375_7520 were highly expressed during the infection of HMECs, whereas H375_8480 and H375_1050 were up-regulated during tick cell infection ( Figure 1 ). Quantitative RT-PCR based analysis of these genes exhibited an overall pattern of expression consistent with the RNA-Seq data, although some...”
CLP_2159 ABC transporter ATP-binding protein from Clostridium butyricum E4 str. BoNT E BL5262
36% identity, 81% coverage
Avin_12800 LPS transport protein LptB from Azotobacter vinelandii AvOP
29% identity, 95% coverage
PP0953 ABC transporter, ATP-binding protein, putative from Pseudomonas putida KT2440
29% identity, 95% coverage
NGO1605 putative ABC transporter, ATP-binding protein from Neisseria gonorrhoeae FA 1090
30% identity, 89% coverage
LOAG_00381 hypothetical protein from Loa loa
35% identity, 15% coverage
- ABC-B transporter genes in Dirofilaria immitis
Bourguinat, International journal for parasitology. Drugs and drug resistance 2016 - “...Cel-PGP-3 WP:CE03818 AAX82635.1 AAX82635.1 Cel-PGP-C CAA46191.1 AAD49436.1 AAD49436.1 Cel-PGP-4a WP:CE44238 Cel-PGP-4b WP:CE03308 L.loa Cel-PGP-5a WP:CE43003 LOAG_00381 EFO28095.2 Cel-PGP-5b WP:CE43182 LOAG_03722 XP_003139307 Cel-PGP-6a WP:CE40818 Cel-PGP-6b WP:CE40819 D.immitis Cel-PGP-6c WP:CE46295 nDi2.2.scaf00004 Genbank: KP296255 Cel-PGP-7 WP:CE36668 nDi2.2.scaf00046 Genbank: KP296249 Cel-PGP-8 WP:CE31624 nDi2.2.scaf00048 Genbank: KP296245 Cel-PGP-9 WP:CE15714 Cel-PGP-10 WP:CE40807 Cel-PGP-11...”
E6MYT4 ABC-type lipopolysaccharide transporter (EC 7.5.2.5) from Neisseria meningitidis serogroup B / serotype 15 (see 2 papers)
NMB0356 ABC transporter, ATP-binding protein from Neisseria meningitidis MC58
30% identity, 89% coverage
- Transcriptional profiling of Neisseria meningitidis interacting with human epithelial cells in a long-term in vitro colonization model
Hey, Infection and immunity 2013 - “...transport (34) were not differentially expressed, except for lptB (NMB0356), which was marginally upregulated at 24 h and 96 h (see the data at http:...”
- The LptD chaperone LptE is not directly involved in lipopolysaccharide transport in Neisseria meningitidis
Bos, The Journal of biological chemistry 2011 - “...genes correspond to locus tags NMB0354, NMB0355, and NMB0356, respectively, in the genome sequence of strain MC58. As explained above, the neisserial homolog of...”
- Virulence determinants, drug resistance and mobile genetic elements of Laribacter hongkongensis: a genome-wide analysis
Lau, Cell & bioscience 2011 - “...Lipopolysaccharide export ABC transporter ATP-binding protein of LptBFGC export complex lptB b3201 LHK_02024 CV3331 NGO1605 NMB0356 Lipopolysaccharide export ABC permease of LptBFGC export complex lptF b4261 LHK_01413 CV2915 NGO1228 NMB1570 Lipopolysaccharide export ABC permease of LptBFGC export complex lptG b4262 LHK_01412 CV2916 NGO1229 NMB1571 LPS assembly...”
ELZ14_04750 LPS export ABC transporter ATP-binding protein from Pseudomonas brassicacearum
28% identity, 95% coverage
- Genetic Potential of the Biocontrol Agent Pseudomonas brassicacearum (Formerly P. trivialis) 3Re2-7 Unraveled by Genome Sequencing and Mining, Comparative Genomics and Transcriptomics
Nelkner, Genes 2019 - “...the biosynthesis of various bacterial cell envelope components, that is, lipopolysaccharides (LPS) (ELZ14_02690, ELZ14_02695, ELZ14_02715, ELZ14_04750, ELZ14_04755, ELZ14_04760, ELZ14_20190). LPS can serve as a barrier to many antibiotics and changes in lipid composition may enable microorganisms to maintain outer membrane functions while facing environmental fluctuations. Interestingly,...”
Q0PAK5 ABC-transporter ATP-binding protein from Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Cj0669 ABC-transporter ATP-binding protein from Campylobacter jejuni subsp. jejuni NCTC 11168
32% identity, 99% coverage
- Rapid identification of novel immunodominant proteins and characterization of a specific linear epitope of Campylobacter jejuni
Hoppe, PloS one 2013 - “...BLASTed and subsequently aligned according to a BLOSUM62 matrix. As a reference sequence TLIKELKRLGI of Q0PAK5, the protein encoded by cj0669 from C. jejuni NCTC 11168 was used. The dots indicate an agreement to the reference, while differences are given by the one letter amino acid...”
- Rapid identification of novel immunodominant proteins and characterization of a specific linear epitope of Campylobacter jejuni
Hoppe, PloS one 2013 - “...immunodominant character by microarrays and ELISA. Subsequently, seven proteins were selected for epitope mapping. For cj0669 and cj0920c linear epitopes were identified. For cj0669, specificity assays revealed a specific linear epitope site. Consequently, an eleven amino acid residue sequence TLIKELKRLGI was analyzed via alanine scan, which...”
- “...these proteins for epitope mapping and succeeded in identifying linear epitopes for two proteins, namely cj0669 and cj0920c not described before. Furthermore, assays were performed to assess specificity of the binding as well as investigating the relevance of the amino acid residues involved via alanine scanning....”
- Characterization of genetically matched isolates of Campylobacter jejuni reveals that mutations in genes involved in flagellar biosynthesis alter the organism's virulence potential
Malik-Kale, Applied and environmental microbiology 2007 - “...fliR, fliY, flgR, flgS, rpoN, Cj0667, Cj0668, and Cj0669) were PCR amplified using KOD DNA polymerase (Novagen, San Diego, CA) and sequenced using gene-specific...”
- “...flhB, metA, rpoN, Cj1514, Cj0667, Cj0668, and Cj0669) was determined by real-time quantitative reverse transcription-PCR (RT-PCR). cDNA was synthesized using...”
A0A071L2Z5 ABC-type lipopolysaccharide transporter (EC 7.5.2.5) from Pseudomonas aeruginosa (see paper)
TC 3.A.1.152.1 / Q9HVV6 Probable ATP-binding component of ABC transporter, component of LPS export system, LptF (M), LptG (M) and LptB (C) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
PA4461 probable ATP-binding component of ABC transporter from Pseudomonas aeruginosa PAO1
28% identity, 95% coverage
- substrates: lipopolysaccharide
tcdb comment: This system is also listed in TCDB under TC#1.B.42.1.2 as part of a multicomponent system. The entire system is described in detail there. LptB2FG extracts LPSs from the IM and transports them to the outer membrane.Luo et al. 2017 reported the crystal structure of nucleotide-free LptB2FG from P. aeruginosa. It shows that LPS transport proteins LptF and LptG each contain a TM domain (TMD), a periplasmic beta-jellyroll-like domain and a coupling helix that interacts with LptB on the cytoplasmic side. The LptF and LptG TMDs form a large outward-facing V-shaped cavity in the IM. Mutational analyses suggested that LPS may enter the central cavity laterally, via the interface of the TMD domains of LptF and LptG, and is expelled into the beta-jellyroll-like domains upon ATP binding and hydrolysis by LptB. These studies suggest a mechanism for LPS extraction by LptB2FG that is distinct from those of classical ABC transporters that transport substrates across the IM (Luo et al. 2017). LptB2FG extracts LPS from the periplasmic face of the IM through a pair of lateral gates and then powers transperiplasmic transport to the OM through a slide formed by either of the periplasmic domains of LptF or LptG, LptC, LptA and the N-terminal domain of LptD. The structural and functional studies of the seven lipopolysaccharide transport proteins provide a platform to explore the unusual mechanisms of LPS extraction, transport and insertion from the inner membrane to the outer membrane (Dong et al. 2017). LptB2 binds novobiocin which stimulates its export activity and renders the membrane more impermeable to novobiocin (Luo et al. 2017 reported the crystal structure of nucleotide-free LptB2FG from P. aeruginosa. It shows that LPS transport proteins LptF and LptG each contain a TM domain (TMD), a periplasmic beta-jellyroll-like domain and a coupling helix that interacts with LptB on the cytoplasmic side. The LptF and LptG TMDs form a large outward-facing V-shaped cavity in the IM. Mutational analyses suggested that LPS may enter the central cavity laterally, via the interface of the TMD domains of LptF and LptG, and is expelled into the beta-jellyroll-like domains upon ATP binding and hydrolysis by LptB. These studies suggest a mechanism for LPS extraction by LptB2FG that is distinct from those of classical ABC transporters that transport substrates across the IM (Luo et al. 2017). LptB2FG extracts LPS from the periplasmic face of the IM through a pair of lateral gates and then powers transperiplasmic transport to the OM through a slide formed by either of the periplasmic domains of LptF or LptG, LptC, LptA and the N-terminal domain of LptD. The structural and functional studies of the seven lipopolysaccharide transport proteins provide a platform to explore the unusual mechanisms of LPS extraction, transport and insertion from the inner membrane to the outer membrane (Dong et al. 2017). LptB2 binds novobiocin which stimulates its export activity and renders the membrane more impermeable to novobiocin (Luo et al. 2017). LptB2FG extracts LPS from the periplasmic face of the IM through a pair of lateral gates and then powers transperiplasmic transport to the OM through a slide formed by either of the periplasmic domains of LptF or LptG, LptC, LptA and the N-terminal domain of LptD. The structural and functional studies of the seven lipopolysaccharide transport proteins provide a platform to explore the unusual mechanisms of LPS extraction, transport and insertion from the inner membrane to the outer membrane (Dong et al. 2017). LptB2 binds novobiocin which stimulates its export activity and renders the membrane more impermeable to novobiocin (May et al. 2017) - Protein-to-mRNA ratios are conserved between Pseudomonas aeruginosa strains
Kwon, Journal of proteome research 2014 - “...2.6 7.2 614.0 662.0 conserved hypothetical protein PA4438 31.1 12.6 731.5 780.0 conserved hypothetical protein PA4461 18.0 7.8 2341.0 2603.0 probable ATP-binding component of ABC transporter PA4557| lytB 2.2 5.8 382.0 420.0 LytB protein PA4837 0.0 3.9 63.0 65.0 probable outer membrane protein precursor PA5013| ilvE...”
- Analysis of Pseudomonas aeruginosa cell envelope proteome by capture of surface-exposed proteins on activated magnetic nanoparticles
Vecchietti, PloS one 2012 - “...Peptidase M41 2 IM,2 msbA PA4997 Lipid A export protein MsbA ABC transporter 2 IM,2 PA4461 Putative ABC transporter ABC transporter 3 IM,2 zipA PA1528 Cell division protein ZipA ZipA 2 IM,3 ppiD PA1805 Peptidyl-prolyl cis-trans isomerase D 2 IM,3 - P,1 secG PA4747 Protein-export protein...”
- Toxicogenomic response of Pseudomonas aeruginosa to ortho-phenylphenol
Nde, BMC genomics 2008 - “...molecules PA0295_at PA0295 2.643 0.0147 probable periplasmic polyamine binding protein Transport of small molecules PA4461_at PA4461 2.24 0.00116 probable ATP-binding component of ABC transporter Transport of small molecules PA5503_at PA5503 2.229 0.000446 probable ATP-binding component of ABC transporter Transport of small molecules PA4450_murA_at PA4450 2.855 0.00044...”
- “...(PA5217), probable periplasmic polyamine binding protein (PA0295) and probable ATP binding component of ABC transporters (PA4461, PA5503) were also upregulated in this group. These findings possibly imply that membrane components of P. aeruginosa were altered and that activated and or facilitated transport of ions, sugars, amino...”
- Pseudomonas 2007
Goldberg, Journal of bacteriology 2008 - “...four proteins that interact with FimX: PA0020, PA3670, PA4461, and FlhF. Overexpression of PA3670 (GldG), an ABC transporter, led to complete suppression of...”
- Negative control of quorum sensing by RpoN (sigma54) in Pseudomonas aeruginosa PAO1
Heurlier, Journal of bacteriology 2003 - “...pRP1-rpoN (kindly provided by Y. Itoh), containing genes PA4461 and rpoN, into pBBR1MCS (Fig. 1). Plasmid pME3836 was constructed by PCR-amplifying a 744-bp...”
- “...Tcr pBBR1MCS with 3.1-kb BamHI-HindIII insert including genes PA4461 and rpoN from pRP1-rpoN; Cmr pME3087 carrying 1.2-kb KpnI-BamHI insert with a deletion in...”
LHK_02024 probable ABC transporter, ATP-binding protein from Laribacter hongkongensis HLHK9
30% identity, 90% coverage
BCAL0814 ABC transporter ATP-binding protein from Burkholderia cenocepacia J2315
32% identity, 88% coverage
PSPTO_4452 ABC transporter, ATP-binding protein from Pseudomonas syringae pv. tomato str. DC3000
27% identity, 95% coverage
PPUBIRD1_3895 ABC transporter ATP-binding protein from Pseudomonas putida BIRD-1
32% identity, 70% coverage
NP_879529 ABC transporter from Bordetella pertussis Tohama I
BP0697 LPS export ABC transporter ATP-binding protein from Bordetella pertussis Tohama I
30% identity, 84% coverage
HI1148 ABC transporter, ATP-binding protein from Haemophilus influenzae Rd KW20
31% identity, 80% coverage
H16_A0388 ABC-type transporter, ATPase component: HAAT family from Ralstonia eutropha H16
29% identity, 85% coverage
SYNW1112 possible ABC transporter, ATP-binding component from Synechococcus sp. WH 8102
29% identity, 89% coverage
- A suppression subtractive hybridization approach reveals niche-specific genes that may be involved in predator avoidance in marine Synechococcus isolates
Jones, Applied and environmental microbiology 2006 - “...NP_897205 NP_896979 NP_896450 NP_898542 NP_898568 SYNW1112 SYNW0886 SYNW0355 SYNW2453 SYNW2479 NP_897305 NP_897365 SYNW1212 SYNW1270 NP_896965 NP_897416...”
- Mapping of orthologous genes in the context of biological pathways: An application of integer programming
Mao, Proceedings of the National Academy of Sciences of the United States of America 2006 - “...is predicted as the ortholog of phnC. In addition, SYNW1112 and SYNW0173 are mapped to tagH and pstB2, respectively, of B. subtilis, all of which were...”
- Computational inference and experimental validation of the nitrogen assimilation regulatory network in cyanobacterium Synechococcus sp. WH 8102
Su, Nucleic acids research 2006 - “...To name few such cases, the urea transporter subunits SYNW2438-2441 (UrtEDCB) form a complex with SYNW1112 (putative ABC transporter), SYNW0320 (putative ABC transporter) and SYNW2480 (putative ABC transporter); and synw0320 and synw2480 were down- and up-regulated by ammonium, respectively ( Figure 2C ). The urease subunits...”
Q3Y5V5 MDR efflux pump ABC3 from Pyricularia grisea
31% identity, 17% coverage
AMK58_21070 LPS export ABC transporter ATP-binding protein from Azospirillum brasilense
30% identity, 79% coverage
BPSL0534 ABC transporter system, ATP-binding protein from Burkholderia pseudomallei K96243
32% identity, 88% coverage
- Biofilm Signaling, Composition and Regulation in Burkholderia pseudomallei
Nyanasegran, Journal of microbiology and biotechnology 2023 - “...and responsible for hydrolysis of Kdo 8-phosphate to Kdo was found located in the operon bpsl0534 - bpsl0538 [ 54 , 95 ]. In this operon, bpsl0534 and bpsl0536 encode the lipopolysaccharide export system ATP-binding proteins (ABC transporter), while bpsl0535 and bpsl0536 were annotated to encode...”
SO0742 iron(III) ABC transporter, ATP-binding protein from Shewanella oneidensis MR-1
29% identity, 66% coverage
SP_RS04030 amino acid ABC transporter ATP-binding protein from Streptococcus pneumoniae TIGR4
31% identity, 89% coverage
- Streptococcus pneumoniae metal homeostasis alters cellular metabolism
Burcham, Metallomics : integrated biometal science 2020 - “...iron ABC-transporter 1.3 GapN SP_RS05545 glyceraldehyde-3-phosphate dehydrogenase ArgR 1.7 ArcB SP_RS10960 ornithine carbamoyltransferase 5.3 ArtM SP_RS04030 ABC-type arginine transport system CtsR 1.4 ClpE SP_RS04015 ATP-dependent Clp protease 11.1 ClpL SP_RS01650 ATP-dependent Clp protease ATP-binding subunit Unknown 10.0 PyrK SP_RS04775 dihydroorotate dehydrogenase electron transfer subunit, oxidoreductase 10.0...”
CIBE_5584 ABC transporter ATP-binding protein from Clostridium beijerinckii
35% identity, 62% coverage
LBJ_RS07965 LPS export ABC transporter ATP-binding protein from Leptospira borgpetersenii serovar Hardjo-bovis str. JB197
29% identity, 89% coverage
- Distinct transcriptional profiles of Leptospira borgpetersenii serovar Hardjo strains JB197 and HB203 cultured at different temperatures
Putz, PLoS neglected tropical diseases 2021 - “...0.04 1.32 0.95 -1.33 Genes not contained in the rfb region but pertaining to LPS LBJ_RS07965 LPS export ABC transporter ATP-binding protein 0.03 -1.17 0.99 1.00 0.50 -1.07 5.56E-3 -1.29 LBJ_RS07975 LPS export ABC transporter periplasmic protein LptC 4.63E-3 -1.27 1.00 1.00 0.66 1.06 0.06 -1.23...”
- “...rfb locus, but annotated as having a function related to LPS were identified; these included LBJ_RS07965 (annotated as encoding an LPS export ABC transporter ATP-binding protein), LBJ_RS07975 (annotated as encoding the LPS export ABC transported periplasmic protein LptC protein), LBJ_RS08415 (annotated as encoding an O-antigen ligase...”
TP0786 ABC transporter, ATP-binding protein, putative from Treponema pallidum subsp. pallidum str. Nichols
TPANIC_0786 LPS export ABC transporter ATP-binding protein from Treponema pallidum subsp. pallidum str. Nichols
28% identity, 89% coverage
- Structural Modeling of the Treponema pallidum Outer Membrane Protein Repertoire: a Road Map for Deconvolution of Syphilis Pathogenesis and Development of a Syphilis Vaccine
Hawley, Journal of bacteriology 2021 - “...Phyre2 LptC; Vibrio cholerae ; 6MJP 18 TP0785 Phyre2 LptA; E. coli ; 2R1A 18 TP0786 Phyre2 LptB; Burkholderia phymatum ; 4WBS 50 TP0883 Phyre2 LptF; Vibrio cholerae ; 6MJP 15 TP0884 Phyre2 LptG; Vibrio cholerae ; 6MJP 17 8-stranded -barrels TP0126 Phyre2, SWISS-MODEL OmpW; E....”
- “...47 ) was used to build the initial 3D structural model of T. pallidum LptB (TP0786), LptF (TP0883), LptG (TP0884), LptC (TP0784), and LptA (TP0785) orthologs. Next, the crystal structure of Vibrio cholerae LptB 2 FGC (PDB accession number 6MJP ) ( 150 ) was applied...”
- The Treponema pallidum Outer Membrane
Radolf, Current topics in microbiology and immunology 2018 - “...yet unidentified cargo reaches the outer leaflet of the CM, TP0883 (LptF), TP0884 (LptG), and TP0786 (LptB) form an ATP-dependent machine that pushes it toward LptC and then across the periplasmic bridge. What could be the cargo for this system in an organism lacking LPS? One...”
- Characterizing the Syphilis-Causing Treponema pallidum ssp. pallidum Proteome Using Complementary Mass Spectrometry
Osbak, PLoS neglected tropical diseases 2016 - “...( S4 Table ), including TprG (TP0317), TprH (TP0610), ABC superfamily ATP binding cassette transporter (TP0786), flagellar hook length control protein FliK (TP0729) and two TolC-like proteins (TP0967 and TP0968). Of the 49/116 reported membrane proteins that could be designated to a COG category, two categories...”
- Comparison of transcriptional profiles of Treponema pallidum during experimental infection of rabbits and in vitro culture: Highly similar, yet different
De, PLoS pathogens 2021 - “...protein Hypothetical protein 150 70 -1.05 5.68E-07 TPANIC_0339 rluA2 RNA binding* 100 45 -1.05 .002 TPANIC_0786 lptB Transport and binding proteins; Unknown substrate 462 218 -1.03 2.58E-12 TPANIC_0301 ABC transporter permease Transmembrane transport* 157 72 -1.01 .001 TPANIC_0336 comE Cellular processes; Transformation 278 132 -1.01 6.43E-06...”
- “...vitro environment: TPANIC_0140 (K + transport protein NtpJ), TPANIC_0840 (major facilitator subfamily [MFS] transporter protein), TPANIC_0786 (ABC transporter ATP binding protein), and TPANIC_0301 (ABC transporter permease). Differences in gene transcripts related to metabolism in T . pallidum cultured in rabbits versus in vitro The transcript levels...”
BC343_09585 LPS export ABC transporter ATP-binding protein from Mucilaginibacter pedocola
29% identity, 88% coverage
SPD_0720 amino acid ABC transporter, ATP-binding protein from Streptococcus pneumoniae D39
DQM66_RS03875 amino acid ABC transporter ATP-binding protein from Streptococcus pneumoniae
30% identity, 89% coverage
RA0C_1993 LPS export ABC transporter ATP-binding protein from Riemerella anatipestifer ATCC 11845 = DSM 15868
30% identity, 88% coverage
- Role of LptD in Resistance to Glutaraldehyde and Pathogenicity in Riemerella anatipestifer
Huang, Frontiers in microbiology 2019 - “...ATCC11845 for homologs of Lpt proteins revealed that LptA, LptB, LptD, LptF, and LptG (RA0C_1913, RA0C_1993, RA0C_1121, RA0C_0335, and RA0C_1496) exhibit 42, 53.78, 48, 19.96, and 30.56% identity to previously identified proteins in E. coli , respectively. Homologs of LptC and LptE were not identified through...”
mll3197 ABC transporter ATP-binding protein (in rpoN upstream) from Mesorhizobium loti MAFF303099
29% identity, 81% coverage
lmo0848 similar to amino acid ABC transporter, ATP-binding protein from Listeria monocytogenes EGD-e
LMRG_02271 glutamine ABC transporter, ATP-binding protein from Listeria monocytogenes 10403S
31% identity, 90% coverage
- Acid shock of Listeria monocytogenes at low environmental temperatures induces prfA, epithelial cell invasion, and lethality towards Caenorhabditis elegans
Neuhaus, BMC genomics 2013 - “...at 37C. These genes include purA , inlH , lmo0540/lmo2229/lmo2754 encoding penicillin-binding proteins, flaA , lmo0848 encoding an ABC transporter, dal , clpE , racE , lpd , bilEA , zurR , zurM , lapB , mprF , gtcA , and ami (Additional files 1 and...”
- Listeria monocytogenes grown at 7° C shows reduced acid survival and an altered transcriptional response to acid shock compared to L. monocytogenes grown at 37° C
Ivy, Applied and environmental microbiology 2012 - “...lmo0683 lmo0806 lmo0808 lmo0809 lmo0810 lmo0811 lmo0847 lmo0848 lmo1041 lmo1046 lmo1089 (tagD) Similar to protein gp35 from bacteriophage A118 Similar to...”
- Global transcriptional analysis of spontaneous sakacin P-resistant mutant strains of Listeria monocytogenes during growth on different sugars
Tessema, PloS one 2011 - “...7 lmo0784 ( mpoA ) mannose-specific PTS component IIA 1.5 10 6 2.1 10 9 lmo0848 amino acid ABC transporter, ATP-binding protein 0.6 10 4 0.7 10 6 lmo1251 regulator of the Fnr CRP family (including PrfA) 1.4 10 7 1.4 10 6 lmo1254 alpha, alpha-phosphotrehalase...”
- “...3 lmo0847 glutamine ABC transporter (binding and transport protein) 0.7 10 5 1.0 10 5 lmo0848 amino acid ABC transporter, ATP-binding protein 0.7 10 5 0.9 10 4 lmo1007 unknown 0.7 10 4 0.7 10 3 lmo1251 regulator of the Fnr CRP family (including PrfA) 2.0...”
- CcpC-dependent regulation of citB and lmo0847 in Listeria monocytogenes
Kim, Journal of bacteriology 2006 - “...the C-terminal region. lmo0847 and the immediate downstream gene (lmo0848), which is highly similar to genes for ATP-binding proteins, seem to be organized in a...”
- L-glutamine Induces Expression of Listeria monocytogenes Virulence Genes
Haber, PLoS pathogens 2017 - “...the first gene of a two-gene operon ( Fig 1A ), the second of which, LMRG_02271 , contains all of the canonical motifs of a nucleotide-binding domain (NBD) of an ABC transporter ( S1 Fig ). Since both genes together are predicted to consist a functional...”
- “...fully abolish L-glutamine binding ( Fig 2C ). Collectively, these results suggest that LMRG_02270 and LMRG_02271 form a high-affinity L-glutamine-specific import system in L . monocytogenes . In accordance with the nomenclature used in other bacteria [ 36 ], [ 38 ], the gene encoding the...”
- Metabolic Genetic Screens Reveal Multidimensional Regulation of Virulence Gene Expression in Listeria monocytogenes and an Aminopeptidase That Is Critical for PrfA Protein Activation
Friedman, Infection and immunity 2017 - “...transport proteins exhibiting distinctive mutant phenotypes include LMRG_02271, representing a glutamine ABC transporter exhibiting a low response in LBM (22),...”
HZ99_RS26135 ABC transporter ATP-binding protein from Pseudomonas fluorescens
29% identity, 70% coverage
- Combined Transcriptome and Proteome Analysis of RpoS Regulon Reveals Its Role in Spoilage Potential of Pseudomonas fluorescens
Liu, Frontiers in microbiology 2019 - “...SpeA 0.397 (4.55E-04) 0.821 (1.61E-02) Down/Down HZ99_RS22590 WP_038446180.1 Glu/Leu/Phe/Val dehydrogenase 0.083 (2.60E-10) 0.293 (3.62E-04) Down/Down HZ99_RS26135 WP_038447234.1 Spermidine/putrescine ABC transporter ATP-binding protein 0.163 (3.69E-04) Down/ HZ99_RS26140 WP_029292823.1 ABC-type spermidine/putrescine transport system, permease component II 0.169 (1.39E-02) Down/ HZ99_RS26155 WP_038447240.1 Spermidine/putrescine-binding periplasmic protein 0.110 (1.70E-02) 0.461 (8.83E-03)...”
AL01_00410 ABC transporter ATP-binding protein from Bombella intestini
31% identity, 85% coverage
AO090009000651 No description from Aspergillus oryzae RIB40
32% identity, 16% coverage
An17g01770 uncharacterized protein from Aspergillus niger
29% identity, 19% coverage
Dtur_1053 ABC transporter related from Dictyoglomus turgidum DSM 6724
32% identity, 79% coverage
MDR2_TRIRC / F2T1C4 ABC multidrug transporter MDR2; Multidrug resistance protein 2 from Trichophyton rubrum (strain ATCC MYA-4607 / CBS 118892) (Athlete's foot fungus) (see 3 papers)
TERG_08613 uncharacterized protein from Trichophyton rubrum CBS 118892
31% identity, 17% coverage
- function: ABC-type efflux transporter involved in the modulation susceptibility to itraconazole.
catalytic activity: itraconazole(in) + ATP + H2O = itraconazole(out) + ADP + phosphate + H(+) (RHEA:33503)
disruption phenotype: Impairs the resistance to itraconazole of the azole-resistant strain TIMM20092. - Trichophyton rubrum Azole Resistance Mediated by a New ABC Transporter, TruMDR3
Monod, Antimicrobial agents and chemotherapy 2019 - “..., TERG_02508 (TruMDR1) 71.5, 1,085; 50.8, 1,404 AFUA_5G06070 mdr1/abcA VRC induced 16622700 ( 22 ) TERG_08613 (TruMDR2) , TERG_08693, TERG_00402, TERG_08751, TERG_04952 (TruMDR5) , TERG_08591 68.5, 1,318; 50.1, 1,032; 49.1, 434; 41.7, 1,349; 40.7, 995; 38.7, 1,349 AFUA_6G03470 fmpD Fumipyrrole 25582336 ( 78 ) TERG_08613 (TruMDR2)...”
- “...ability to provide resistance to azoles ( Table 3 ). Four candidates, encoded by TERG_02508, TERG_08613, TERG_02186, and TERG_04952, were able to render the yeasts resistant to one or several azoles. TERG_02508 and TERG_08613 correspond to TruMDR1 and TruMDR2, respectively, which were previously reported ( 10...”
- The Transcriptional Profile of Trichophyton rubrum Co-Cultured with Human Keratinocytes Shows New Insights about Gene Modulation by Terbinafine
Petrucelli, Pathogens (Basel, Switzerland) 2019 - “...selected for validation: genes involved in ergosterol biosynthesis (TERG_01703; TERG_05717), MFS and ABC transporters (TERG_02822; TERG_08613), genes involved in T. rubrum metabolism and nutrient transport (TERG_08278; TERG_02609; TERG_06106; TERG_02542), and some potential antifungal targets that were also modulated in the presence of the drug (TERG_03223; TERG_08480;...”
- “...Fold Change: 1.89), TERG_05575 (Log 2 Fold Change: 1.54), TERG_06679 (Log 2 Fold Change: 1.95), TERG_08613 (Log 2 Fold Change: 1.63), and TERG_08751 (Log 2 Fold Change: 2.07). The modulation of these genes might be associated with the efflux of this allylamine and with resistance of...”
- Trans-chalcone activity against Trichophyton rubrum relies on an interplay between signaling pathways related to cell wall integrity and fatty acid metabolism
Bitencourt, BMC genomics 2019 - “...Phospholipase a2 F: 5- GCCACGAGGATACGACTTTAT-3 R:5- ATCAACCTTCTTGCGGTAGTC-3 106 TERG_02134 Indoleamine-dioxygenase F:5- CTGCAGCGTATGCCAATAAAG-3 R:5- GAGCAGTGAGATCAGGTAACTC-3 103 TERG_08613 Tru MDR2 F: 5- GCACTGATCTGCAGCTCGACC-3 R:5 CCAACGTCATCCTCCCAGAC-3 91 TERG_00832 CMGC/MAPK protein kinase (Erk1) F: 5- CTTGAAGCCCGGTAACCTATT-3 R: 5- CGGTCATATATCCAGCGTTCTC 3 113 TERG_07904 *Beta-tubulin F: 5- AACATGATGGCTGCCACTGA-3 R: 5 - AAGATGGCAGAGCAGGTAAGGT-3...”
- RNA-sequencing analysis of Trichophyton rubrum transcriptome in response to sublethal doses of acriflavine
Persinoti, BMC genomics 2014 - “...transporter TERG_00820 -1.06 -1.49 -2.30 MFS multidrug resistance transporter TERG_08130 -1.29 -1.70 -1.77 ABC transporter TERG_08613 -1.09 -1.70 -2.14 Multidrug resistance protein Mdr2 TERG_00955 -1.66 -1.79 -2.29 ABC efflux transporter TERG_05153 -1.48 -1.89 -2.37 MFS transporter TERG_00402 -1.60 -2.10 -2.25 Multidrug resistance protein TERG_06161 -2.42 -2.26...”
- “...1.77 2.45 3.35 2.80 3.24 TERG_06053 Catalase (peroxisomal catalase) 6.09 1.01 7.13 4.26 6.49 4.43 TERG_08613 Multidrug resistance protein Mdr2 -1.09 -0.85 -1.70 -1.34 -2.14 -1.70 TERG_07801 ABC multidrug transporter Mdr4 -0.69 0.91 2.6 1.63 3.13 2.30 Isocitrate lyase (ICL) activity ICL specific activity, measured in...”
RSP_2696 ABC transporter, fused ATPase and inner membrane subunits from Rhodobacter sphaeroides 2.4.1
32% identity, 37% coverage
- Convergence of the transcriptional responses to heat shock and singlet oxygen stresses
Dufour, PLoS genetics 2012 - “...Amino acids, peptides and amines RSP_1564 Cations and iron carrying compounds RSP_2542, RSP_2891 Unknown substrate RSP_2696, RSP_2897 DNA metabolism DNA replication, recombination, and repair RSP_1074, RSP_2815, RSP_4199 Purine ribonucleotide biosynthesis RSP_2454 Cellular processes Adaptations to atypical conditions RSP_4198 Detoxification RSP_0890, RSP_1058 Central intermediary metabolism Other RSP_1196,...”
gbs0120 Unknown from Streptococcus agalactiae NEM316
30% identity, 81% coverage
- Visualization of the role of host heme on the virulence of the heme auxotroph Streptococcus agalactiae
Joubert, Scientific reports 2017 - “...the hostile host environment. Results Role of hrtBA in controlling GBS heme toxicity GBS0119 and GBS0120 showed respectively 30% and 45% amino acid identity with HrtB and HrtA of S. aureus 17 . In GBS, the operon comprises 2 additional genes, gbs0121 and gbs0122 ( Fig....”
- “.... Schematic representation of the hrtBAhssRS operon in S.agalactiae (NEM316). HrtB (gbs0119 ) and hrtA (gbs0120 ) encode a permease and an ATPase, respectively while hssS (gbs0122 ) and hssR (gbs0121 ) encode the sensor histidine kinase and response regulator of a two-component system. ( B...”
- Two coregulated efflux transporters modulate intracellular heme and protoporphyrin IX availability in Streptococcus agalactiae
Fernandez, PLoS pathogens 2010 - “...in S. aureus and shown to be involved in heme toxicity [37] . Gbs0119 and Gbs0120 showed 45% and 29% identity with HrtB and HrtA of S. aureus respectively. We used Northern blot experiments ( Fig. 5A ) and a lacZ promoter fusion, P gbs0119 -lacZ...”
- “...provokes accrued heme sensitivity [28] , [27] . The S. agalactiae hrtAB homologous system ( gbs0120 gbs0119 ) is likely to have a similar role in limiting heme toxicity. In contrast, the pef regulon is activated by PPIX, and at heme concentrations that do not induce...”
LGAS_1844 Cytochrome bd biosynthesis ABC-type transporter, ATPase and permease component from Lactobacillus gasseri ATCC 33323
29% identity, 39% coverage
- Heme and menaquinone induced electron transport in lactic acid bacteria
Brooijmans, Microbial cell factories 2009 - “...ATCC 334 LSEI_2205 LSEI_0012 b LSEI_2204 LSEI_2203 LSEI_2202 Lactobacillus gasseri ATCC 33323 LGAS_1841 LGAS_1842 LGAS_1843 LGAS_1844 Lactobacillus johnsonii NCC 533 LJ1810 LJ1811 LJ1812 (2e-116) LJ1813 (5e-110) Lactobacillus plantarum WCFS1 lp_1125 lp_1126 lp_1128 lp_1129 Lactobacillus reuteri 100-23 e Lr_0600 e Lr_0599 e Lr_0598 (3e-140) e Lr_0597(3e-120) Lactobacillus...”
C4R9D9 Multidrug resistance protein from Komagataella phaffii (strain GS115 / ATCC 20864)
F2QQK6 Plasma membrane ATP-binding cassette transporter required for the export of a-factor from Komagataella phaffii (strain ATCC 76273 / CBS 7435 / CECT 11047 / NRRL Y-11430 / Wegner 21-1)
33% identity, 16% coverage
LIC10580 ABC transporter, atp-binding protein from Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130
32% identity, 36% coverage
XP_623564 multidrug resistance protein homolog 49 isoform X1 from Apis mellifera
30% identity, 18% coverage
SP_0709 amino acid ABC transporter, ATP-binding protein from Streptococcus pneumoniae TIGR4
30% identity, 89% coverage
ATRD_EMENI / Q5BAY0 ABC multidrug transporter atrD from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) (see 2 papers)
31% identity, 17% coverage
- function: Pleiotropic ABC efflux transporter involved in the protection of the cells against a wide range of toxic compounds (PubMed:10954082). Confers resistance to the azole fenarimol via efflux transport (PubMed:10954082). May also be involved in the secretion of penicillin (PubMed:10954082).
disruption phenotype: Leads to the cellular accumulation of fenarimol (PubMed:10954082). Leads to increased susceptibility to cycloheximide, the cyclosporin derivative PSC 833, nigericin and valinomycin (PubMed:10954082).
ATRD_EMEND / Q9Y8G1 ABC multidrug transporter atrD from Emericella nidulans (Aspergillus nidulans) (see 2 papers)
atrD ABC-transporter from Emericella nidulans (see paper)
31% identity, 17% coverage
- function: Pleiotropic ABC efflux transporter involved in the protection of the cells against a wide range of toxic compounds (PubMed:10954082). Confers resistance to the azole fenarimol via efflux transport (PubMed:10954082). May also be involved in the secretion of penicillin (PubMed:10954082).
disruption phenotype: Leads to the cellular accumulation of fenarimol (PubMed:10954082). Leads to increased susceptibility to cycloheximide, the cyclosporin derivative PSC 833, nigericin and valinomycin (PubMed:10954082). - CharProtDB Description: Putative ATP-binding cassette (ABC) transporter of the P-glycoprotein cluster; plays a role in protection against cytotoxic agents, in antibiotic secretion and in the efflux of the azole-related fungicide fenarimol; Source:AspGD
LSA0272 Putative multidrug ABC exporter, ATP-binding and membrane-spanning/permease subunits from Lactobacillus sakei subsp. sakei 23K
29% identity, 36% coverage
- Global transcriptome response in Lactobacillus sakei during growth on ribose
McLeod, BMC microbiology 2011 - “...ABC exporter, membrane-spanning/permease subunit -0.7 LSA0271 lsa0271 Putative multidrug ABC exporter, ATP-binding subunit -0.7 -0.6 LSA0272 lsa0272 Putative multidrug ABC exporter, ATP-binding and membrane-spanning/permease subunits -0.6 -0.6 LSA0308 lsa0308 Putative drug:H(+) antiporter -0.7 LSA0376 lsa0376 Putative transport protein 0.7 LSA0420 lsa0420 Putative drug:H(+) antiporter (N-terminal fragment),...”
BB0466 ABC transporter, ATP-binding protein from Borrelia burgdorferi B31
28% identity, 79% coverage
- Identification of a novel transport system in Borrelia burgdorferi that links the inner and outer membranes
Bowen, Pathogens and disease 2023 - “...of LptD (Kenedy et al. 2016 ). Pukter et al. ( 2015 ) identified BB0465, BB0466, BB0807/BB0808, and BB0838 as orthologs to LptA, LptB, LptF/LptG, and LptD, respectively. Here, we describe the identification of B. burgdorferi protein BB0464, an ortholog to LptC, and provide evidence that...”
- “...of the LPT system in B. burgdorferi (consisting of proteins encoded by ORFs bb0464, bb0465, bb0466, bb0807, bb0808 , and bb0838 ) and empirically determined that these proteins interact as would be expected of an LPT system. While the presence of a putative LPS transport system...”
- A Borrelia burgdorferi LptD homolog is required for flipping of surface lipoproteins through the spirochetal outer membrane
He, Molecular microbiology 2023 - “...( Tatusov et al. , 2000 ) identified B. burgdorferi homologs for LptA (BB0465), LptB (BB0466), LptF (BB0807) and LptG (BB0808), but no clear LptC homolog. In other bacterial systems, LptC is often encoded within the same locus as LptA and LptB in a lptCAB operon...”
- “...short N-terminal -helix following four disordered tether residues after the predicted N-terminal cysteine. The LptB (BB0466) model predictably assumed the structural fold of an ABC transporter ATPase (pLDDT 92.8). The LptF (BB0807) model showed six transmembrane helixes, with the third helix uniquely extending into the periplasm...”
- Rrp1, a cyclic-di-GMP-producing response regulator, is an important regulator of Borrelia burgdorferi core cellular functions
Rogers, Molecular microbiology 2009 - “...236 0.0343 Narasimhan et al . (2002) BB0451 chromate transport protein, putative TP 63.0 0.0475 BB0466 ABC transporter, ATP-binding protein TP 12.4 0.0404 BB0475 lipoprotein, putative CE 4.66 0.0231 BB0530 hypothetical protein U 7.66 0.0172 BB0531 hypothetical protein U 11.0 0.0387 BB0553 hypothetical protein U 6.61...”
YP_001168064 ABC transporter related from Rhodobacter sphaeroides ATCC 17025
31% identity, 37% coverage
DOFOFD_07020 LPS export ABC transporter ATP-binding protein from Sorlinia euscelidii
30% identity, 83% coverage
- <i>Sorlinia euscelidii</i> gen. nov., sp. nov., a novel acetic acid bacterium isolated from the leafhopper <i>Euscelidius variegatus</i> (<i>Hemiptera</i>: <i>Cicadellidae</i>)
Marasco, International journal of systematic and evolutionary microbiology 2024 - “...; DOFOFD_00600-30), lipoprotein transport ( lolCDE ; DOFOFD_11015-20), lipopolysaccharides transport ( lptBFG ; DOFOFD_06240-50, DOFOFD_10815-20, DOFOFD_07020), haem transport ( ccmABC excluding ccmD ; DOFOFD_05470-75, DOFOFD_06305) and phospholipid transport ( mlCDEF excluding mlB ; DOFOFD_10665-75, DOFOFD_03940-45, DOFOFD_01105, DOFOFD_07810, DOFOFD_00795, DOFOFD_04945). Several genes related to exopolysaccharide biosynthesis (...”
AL01_00180 LPS export ABC transporter ATP-binding protein from Bombella intestini
30% identity, 85% coverage
- Whole-Genome Sequence Analysis of Bombella intestini LMG 28161T, a Novel Acetic Acid Bacterium Isolated from the Crop of a Red-Tailed Bumble Bee, Bombus lapidarius
Li, PloS one 2016 - “...AL01_07895, AL01_01955, AL01_02560, AL01_04765, AL01_08515 ABC transporter substrate-binding protein AL01_03865 ABC transporter ATP-binding protein AL01_06795, AL01_00180, AL01_00230, AL01_01625, AL01_01630, AL01_01950 Multidrug ABC transporter AL01_08210, AL01_08950 Multidrug ABC transporter substrate-binding protein AL01_02460 Multidrug ABC transporter ATPase AL01_05575 Peptide ABC transporter permease AL01_07685 Amino acid ABC transporter permease...”
MGYG_04329 leptomycin B resistance protein pmd1 from Nannizzia gypsea CBS 118893
31% identity, 17% coverage
B488_13000 LPS export ABC transporter ATP-binding protein from Liberibacter crescens BT-1
29% identity, 86% coverage
PXO_02228 ABC transporter ATP-binding protein from Xanthomonas oryzae pv. oryzae PXO99A
29% identity, 83% coverage
Clocel_4224 peptidase domain-containing ABC transporter from Clostridium cellulovorans 743B
27% identity, 32% coverage
- Novel LanT associated lantibiotic clusters identified by genome database mining
Singh, PloS one 2014 - “...Herpetosiphon aurantiacus DSM 785 YP_001546505.1 Haur_3741 38 Unknown DUF4135 a 34 Clostridium cellulovorans 743B YP_003845649.1 Clocel_4224 35 [18] LanM 35 Ktedonobacter racemifer DSM 44963 ZP_06966373.1 Krac_11031 37 Unknown LanM 36 Streptomyces roseosporus NRRL 15998 ZP_06586195.1 SSGG_04023 37 Unknown LanM 37 Streptomyces roseosporus NRRL 11379 ZP_04710453.1 SrosN1_010100020975...”
CpecA_0283, CpecF_0282 LPS export ABC transporter ATP-binding protein from Chlamydia pecorum DBDeUG
27% identity, 95% coverage
- Comparative genomics of koala, cattle and sheep strains of Chlamydia pecorum
Bachmann, BMC genomics 2014 - “...are under positive selection, including one of the putative Type III effectors (locus tags: CpecG_0280, CpecA_0283, CpecF_0282) and two conserved hypothetical proteins (see Additional file 2 ). Within the koala C. pecorum strains themselves, all the genes in this region are under purifying selection with mostly...”
- “...under positive selection, including one of the putative Type III effectors (locus tags: CpecG_0280, CpecA_0283, CpecF_0282) and two conserved hypothetical proteins (see Additional file 2 ). Within the koala C. pecorum strains themselves, all the genes in this region are under purifying selection with mostly synonymous...”
TTHERM_00240450 ABC transporter family protein from Tetrahymena thermophila SB210
31% identity, 16% coverage
MDR2_TRIIM / A0A059JJ46 ABC multidrug transporter MDR2; Multidrug resistance protein 2 from Trichophyton interdigitale (strain MR816) (see 4 papers)
30% identity, 17% coverage
- function: Pleiotropic ABC efflux transporter that may be involved in the modulation susceptibility to a wide range of unrelated cytotoxic compounds, including terbinafine, 4-nitroquinoline N-oxide, and ethidium bromide (PubMed:16849730). May play a role in pathogenicity (PubMed:19141731).
catalytic activity: itraconazole(in) + ATP + H2O = itraconazole(out) + ADP + phosphate + H(+) (RHEA:33503)
disruption phenotype: Leads to increased sensitivity to terbinafine, 4- nitroquinoline N-oxide, and ethidium bromide (PubMed:16849730). Leads to a reduction in infecting activity, characterized by low growth on human nails (PubMed:19141731). Impairs the MDR4 induction when the fungus is challenged with amphotericin B or terbinafine (PubMed:27121717).
AKL23_RS07400 amino acid ABC transporter ATP-binding protein from Streptococcus thermophilus
31% identity, 79% coverage
- Technological and Genomic Analysis of Roles of the Cell-Envelope Protease PrtS in Yoghurt Starter Development
Tian, International journal of molecular sciences 2018 - “...transporter substrate-binding protein A9497_01795 A9497_01800 A9497_09175 AKL23_RS05340 AKL23_RS05345 AKL23_RS03035 ABC transporter permease A9497_03790 A9497_09180 AKL23_RS03040 AKL23_RS07400 ABC transporter ATP-binding protein Methionine A9497_07635 AKL23_RS01505 ABC transporter ATP-binding protein A9497_07640 AKL23_RS01510 ABC transporter permease Polar amino acid A9497_03800 AKL23_RS07410 ABC transporter permease Serine/threonine A9497_07645 AKL23_RS01515 Transporter SstT Threonine...”
FN0695 ABC transporter ATP-binding protein from Fusobacterium nucleatum subsp. nucleatum ATCC 25586
27% identity, 89% coverage
- Proteomics of Fusobacterium nucleatum within a model developing oral microbial community
Hendrickson, MicrobiologyOpen 2014 - “...FN0332, FN0341, FN0352, FN0375, FN0376, FN0377, FN0397, FN0398, FN0399, FN0400, FN0450, FN0598, FN0658, FN0660, FN0685, FN0695, FN0793, FN0800, FN0801, FN0827, FN0828, FN1022, FN1080, FN1086, FN1135, FN1136, FN1166, FN1167, FN1187, FN1190, FN1198, FN1256, FN1301, FN1348, FN1349, FN1352, FN1353, FN1354, FN1362, FN1363, FN1398, FN1420, FN1432, FN1480, FN1525, FN1701,...”
- “...FN1898, FN1989, FN2008, FN2009, FN2102, FN2105, FN2106. 2 Covers FN0130, FN0236, FN0450, FN0598, FN0658, FN0660, FN0695, FN0827, FN0828, FN1080, FN1301, FN1348, FN1349, FN1352, FN1353, FN1354, FN1701,FN2102. 3 Covers FN0660, FN0793, FN0800, FN0801, FN1187, FN1398, FN1432, FN1801. 4 Covers FN0192, FN0396, FN0397, FN0399, FN0400, FN0998, FN1111, FN1359,...”
TC 3.A.1.201.20 / I7LXH0 12 TMS multidrug resistance transprter of 1318 aas, AbcB15 (Xiong et al. 2010) is the probable exporter of dichlorodiphenyltrichloroethane (DDT). Expression is induced by treatment with DDT, and this transporter appears to be responsible for DDT tolerance by pumping it out of the cell from Tetrahymena thermophila (strain SB210)
31% identity, 16% coverage
- substrates: Dichlorodiphenyltrichloroethane, drugs
ABCB5_HUMAN / Q2M3G0 ATP-binding cassette sub-family B member 5; ABCB5 P-gp; P-glycoprotein ABCB5; EC 7.6.2.2 from Homo sapiens (Human) (see 11 papers)
Q2M3G0 ABC-type xenobiotic transporter (EC 7.6.2.2) from Homo sapiens (see 2 papers)
NP_001157413 ATP-binding cassette sub-family B member 5 isoform 1 from Homo sapiens
31% identity, 16% coverage
- function: Energy-dependent efflux transporter responsible for decreased drug accumulation in multidrug-resistant cells (PubMed:12960149, PubMed:15205344, PubMed:15899824, PubMed:22306008). Specifically present in limbal stem cells, where it plays a key role in corneal development and repair (By similarity).
catalytic activity: daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+) (RHEA:33147) - Evaluation of ABCB5 immunostained epithelial stem cells in oral squamous cell carcinoma, inflammatory gingival hyperplasia and normal mucosa.
Aadithi, Biotechnic & histochemistry : official publication of the Biological Stain Commission 2024 (PubMed)- GeneRIF: Evaluation of ABCB5 immunostained epithelial stem cells in oral squamous cell carcinoma, inflammatory gingival hyperplasia and normal mucosa.
- Identification of two novel heterodimeric ABC transporters in melanoma: ABCB5β/B6 and ABCB5β/B9.
Gerard, The Journal of biological chemistry 2024 - GeneRIF: Identification of two novel heterodimeric ABC transporters in melanoma: ABCB5beta/B6 and ABCB5beta/B9.
- Islet Co-Expression of CD133 and ABCB5 in Human Retinoblastoma Specimens.
Zschoche, Klinische Monatsblatter fur Augenheilkunde 2023 (PubMed)- GeneRIF: Islet Co-Expression of CD133 and ABCB5 in Human Retinoblastoma Specimens.
- ABCB5+ mesenchymal stromal cells facilitate complete and durable wound closure in recessive dystrophic epidermolysis bullosa.
Dieter, Cytotherapy 2023 - GeneRIF: ABCB5[+] mesenchymal stromal cells facilitate complete and durable wound closure in recessive dystrophic epidermolysis bullosa.
- Changes in Expression and Function of Placental and Intestinal P-gp and BCRP Transporters during Pregnancy.
Szatmári, International journal of molecular sciences 2023 - GeneRIF: Changes in Expression and Function of Placental and Intestinal P-gp and BCRP Transporters during Pregnancy.
- Consecutive dosing of UVB irradiation induces loss of ABCB5 expression and activation of EMT and fibrosis proteins in limbal epithelial cells similar to pterygium epithelium.
Domdey, Stem cell research 2022 - GeneRIF: Consecutive dosing of UVB irradiation induces loss of ABCB5 expression and activation of EMT and fibrosis proteins in limbal epithelial cells similar to pterygium epithelium.
- IS THERE A CLINICAL PATHOLOGICAL CORRELATION OF COLORECTAL ADENOCARCINOMA WITH THE IMMUNOHISTOCHEMICAL EXPRESSION OF OPN AND ABCB5?
Castoldi, Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery 2021 - GeneRIF: IS THERE A CLINICAL PATHOLOGICAL CORRELATION OF COLORECTAL ADENOCARCINOMA WITH THE IMMUNOHISTOCHEMICAL EXPRESSION OF OPN AND ABCB5?
- Wnt/IL-1β/IL-8 autocrine circuitries control chemoresistance in mesothelioma initiating cells by inducing ABCB5.
Milosevic, International journal of cancer 2020 (PubMed)- GeneRIF: ABCB5 may represent a new target to chemosensitize MPM IC and a potential biomarker to predict the response to the first-line chemotherapy in malignant pleural mesothelioma patients
- More
- PGP-14 establishes a polar lipid permeability barrier within the C. elegans pharyngeal cuticle.
Kamal, PLoS genetics 2023 - “...sequences were downloaded from Uniprot and are as follows: Human ABCB1(aka MDR1)(P08183), ABCB4(aka MDR3)(P21439), ABCB5 (Q2M3G0), ABCB11 (BSEP)(O95342), and C . elegans PGP-2 (G5EDF9), PGP-9 (G5EG58), PGP-12 (Q19733), PGP-13 (Q19734), PGP-14 (G5EG61). Black underline indicates the alpha-helixes that are the presumptive PGP-14 transmembrane domains as predicted...”
- “...PGP-10 (Q18824), PGP-11 (Q19015), PGP-12 (Q19733), PGP-13 (Q19734), PGP-14 (G5EG61), ABCB1(aka MDR1)(P08183), ABCB4(aka MDR3)(P21439), ABCB5 (Q2M3G0), and ABCB11 (BSEP)(O95342). In the alignment, red letters represent small and hydrophobic residues, blue letters represent acidic residues, magenta letters indicate basic residues, and green letters represent hydroxyl, sulfhydryl and...”
- Uncovering the mechanism of the effects of Paeoniae Radix Alba on iron-deficiency anaemia through a network pharmacology-based strategy
Ye, BMC complementary medicine and therapies 2020 - “...acid binding 14 O95342 ABCB11 ATP binding cassette subfamily B member 11 hydrolase; protease 15 Q2M3G0 ABCB5 ATP binding cassettesubfamily B member 5 hydrolase; protease 16 P22303 ACHE Acetylcholinesterase hydrolase; protease 17 P03956 MMP1 matrix metallopeptidase 1 hydrolase; protease 18 P00734 F2 coagulation factor II, thrombin...”
- THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Transporters
Alexander, British journal of pharmacology 2017 - “...of cholesterol gallstones [ 251 ]. Nomenclature ABCB5 ABCB6 ABCB7 ABCB8 HGNC, UniProt ABCB5 , Q2M3G0 ABCB6 , Q9NP58 ABCB7 , O75027 ABCB8 , Q9NUT2 Common abreviation MTABC3 ABC7 MABC1 Comments A drug efflux transporter that has been shown to identify cancer stemlike cells in diverse...”
- The Concise Guide to PHARMACOLOGY 2015/16: Transporters
Alexander, British journal of pharmacology 2015 - “...UniProt ABCB1 , P08183 TAP1 , Q03518 TAP2 , Q03519 ABCB4 , P21439 ABCB5 , Q2M3G0 Comments Responsible for the cellular export of many therapeutic drugs. The mouse and rat have two Abcb1 genes (gene names; Abcb1a and Abcb1b) while the human has only the one...”
- Biological pathways modulated by antipsychotics in the blood plasma of schizophrenia patients and their association to a clinical response.
Martins-de-Souza, NPJ schizophrenia 2015 - “...5.344 2 Zinc finger protein 215 Reg. nucleic acid metab DNA binding protein DNA binding Q2M3G0 ABCB5_HUMAN ABCB5 31 90,173 64.78 Up 1.559 2 ATP-binding cassette sub-family B member 5 Transport Integral membrane protein Transporter activity Q86UQ4 ABCAD_HUMAN ABCA13 70 580,604 12.73 Up 5.368 2 ATP-binding...”
- ABCB5 is a limbal stem cell gene required for corneal development and repair.
Ksander, Nature 2014 - “...human scFv phage display library for selection of binders to biotin-peg2-ABCB5 peptide (RFGAYLIQAGRMTPEG; UniProt accession Q2M3G0), followed by sequence analysis and human IgG1 conversion. The monoclonal antibody 3B9 binds to human ABCB5 peptide (RFGAYLIQAGRMT PEG; UniProt accession Q2M3G0) and mouse Abcb5 peptide (RFGAYLIQAGRM MPEG; UniProt accession...”
- The Concise Guide to PHARMACOLOGY 2013/14: transporters
Alexander, British journal of pharmacology 2013 - “...Transports phosphatidylcholine from intracellular to extracellular face of the hepatocyte canalicular membrane 13 ABCB5 ABCB5, Q2M3G0 Multidrug resistance protein in, and marker of, melanoma cells 17 ABCB6 MTABC3 ABCB6, Q9NP58 Putative mitochondrial porphyrin transporter 11 ; other subcellular localizations are possible, such as the plasma membrane,...”
- Identification of tubulins as substrates of serine protease HtrA1 by mixture-based oriented peptide library screening.
Chien, Journal of cellular biochemistry 2009 - “...IAP1 (Q13489) KRT12 (Q99456) CEACAM19 (Q7Z692) MDR3 (P21439) 11/11 IAP2 (Q13490) KRT13 (P13646) FAK1(Q05397) ABCB5 (Q2M3G0) 11/11 IAP3 (P98170) KRT14 (P02533) FAK2(Q14289) ABCB6 (Q9NP58) 8/14 LIVIN (Q96CA5) KRT15 (P19012) ICAM1 (P05362) ABCB7 (O75027) 10/11 SIVA (O15304) TUBA (alpha) ICAM3 (P32942) ABCB8 (Q9NUT2) 9/14 TAIP2 (Q8WYN3) TUBB...”
TC 3.A.1.201.13 / Q2M3G0 Plasma membrane AbcB5, of 812 aas and 6 TMSs, mediates resistance of tumor cells to doxorubicin and other drugs including taxanes and anthracyclines (Kawanobe et al. 2012) by catalyzing efflux of these drugs from Homo sapiens (see 8 papers)
31% identity, 25% coverage
- substrates: Rhodamine, doxorubicin, drugs
tcdb comment: Expression in metastatic melanoma cells is affected by nano-TiO2 exposure, which as a sunscreen ingredient, may play a role in metastatic melanoma progression (Zdravkovic et al. 2019)
MDR2_TRIEC / F2PRR1 ABC multidrug transporter MDR2; Multidrug resistance protein 2 from Trichophyton equinum (strain ATCC MYA-4606 / CBS 127.97) (Horse ringworm fungus) (see paper)
MDR2_TRIT1 / F2RP52 ABC multidrug transporter MDR2; Multidrug resistance protein 2 from Trichophyton tonsurans (strain CBS 112818) (Scalp ringworm fungus) (see paper)
30% identity, 17% coverage
- function: Pleiotropic ABC efflux transporter that may be involved in the modulation susceptibility to a wide range of unrelated cytotoxic compounds.
catalytic activity: itraconazole(in) + ATP + H2O = itraconazole(out) + ADP + phosphate + H(+) (RHEA:33503) - function: Pleiotropic ABC efflux transporter that may be involved in the modulation susceptibility to a wide range of unrelated cytotoxic compounds.
catalytic activity: itraconazole(in) + ATP + H2O = itraconazole(out) + ADP + phosphate + H(+) (RHEA:33503)
lp_3040 ABC transporter, ATP-binding protein from Lactobacillus plantarum WCFS1
29% identity, 38% coverage
SACOL1915 amino acid ABC transporter, ATP-binding protein from Staphylococcus aureus subsp. aureus COL
SA1674 glutamate ABC transporter ATP-binding protein from Staphylococcus aureus subsp. aureus N315
SAOUHSC_01990 amino acid ABC transporter, ATP-binding protein, putative from Staphylococcus aureus subsp. aureus NCTC 8325
SAUSA300_1807 amino acid ABC transporter, ATP-binding protein from Staphylococcus aureus subsp. aureus USA300_FPR3757
NWMN_1749 glutamine transport ATP-binding protein from Staphylococcus aureus subsp. aureus str. Newman
31% identity, 89% coverage
- A new oxidative sensing and regulation pathway mediated by the MgrA homologue SarZ in Staphylococcus aureus
Chen, Molecular microbiology 2009 - “...Acetyl-CoA carboxylase, accC homologue SACOL1847 3.8 Conserved hypothetical protein SACOL1849 2.3 - Conserved hypothetical protein SACOL1915 4.1 Glutamate ABC transporter SACOL1916 3.8 Amino acid ABC transporter SACOL2461 3.7 + Conserved hypothetical protein SACOL2579 3.6 Phytone dehydrogenase SACOL2585 4.0 -2.0 pfoS/R like regulatory protein SACOL2619 3.1 -2.4...”
- Sulfide Homeostasis and Nitroxyl Intersect via Formation of Reactive Sulfur Species in Staphylococcus aureus
Peng, mSphere 2017 - “...3.4 Hypothetical (fibrinogen binding) NWMN_1070 SA1004 6.9 Hypothetical (fibrinogen binding) NWMN_1352 SA1275 5.0 Hypothetical NWMN_1749 SA1674 tcyC 1.8 e 7.1 ABC transporter: cystine (ATPase) e + Down NWMN_1750 SA1675 tycB 1.6 e 6.7 ABC transporter: cystine (permease) e + Down NWMN_1751 SA1676 tycA 1.2 e 4.8...”
- “...acid permease NWMN_1348 SA1271 ilvA 12.9 Threonine dehydratase NWMN_1349 SA1272 ald 22.8 Alanine dehydrogenase NWMN_1749 SA1674 3.9 Glutamine transport NWMN_1850 SA1728 nadE 3.8 NAD synthetase (glutamine or ammonia dependent) NWMN_1872 SA1751 map 5.4 MHC class II analog protein NWMN_2268 SA2156 12.7 l -Lactate permease 2 NWMN_2301...”
- Overexpression of genes of the cell wall stimulon in clinical isolates of Staphylococcus aureus exhibiting vancomycin-intermediate- S. aureus-type resistance to vancomycin
McAleese, Journal of bacteriology 2006 - “...SA1602 SA0010 SA0178 SA0179 SA0180 SA0821 SA0822 SA1272 SA1674 SA1675 SA2135 SA2255 SA2425 SA2427 SA2428 SA0668 SA0199 SA0200 SA0847 SA2251 SA2252 SA2253 SA2254...”
- Spontaneous formation of MXene-oxidized sono/chemo-dynamic sonosensitizer/nanocatalyst for antibacteria and bone-tissue regeneration
Yu, Journal of nanobiotechnology 2023 - “...were upregulated, which were related to carbohydrate metabolism. In addition, the expression of genes (SAOUHSC_02137, SAOUHSC_01990 and SAOUHSC_01991) associated with cell membrane transport proteins was decreased. Importantly, the expression of genes (rpsS, inf-3, mutL, rplC and rpmG) associated with protein synthesis was also reduced. This may...”
- Clemastine Inhibits the Biofilm and Hemolytic of Staphylococcus aureus through the GdpP Protein
Shang, Microbiology spectrum 2022 - “...SAOUHSC_02003 0.49 Putative multidrug export ATP-binding/permease protein SAOUHSC_02003 PhnC 0.17 Phphonates import ATP-binding protein PhnC SAOUHSC_01990 0.10 Amino acid ABC transporter, ATP-binding protein, putative SAOUHSC_02397 0.14 ABC transporter, ATP-binding protein, putative Iron metabolism IsdA 4.69 Iron-regulated surface determinant protein A IsdF 6.92 Iron-regulated surface determinant protein...”
- Functional analysis of the EsaB component of the Staphylococcus aureus Type VII secretion system
Casabona, Microbiology (Reading, England) 2017 - “...SAOUHSC_02941 nrdG 4.9 Anaerobic ribonucleotide reductase activating protein ns SAOUHSC_00717 saeP 4.7 Putative lipoprotein 1.4 SAOUHSC_01990 glnQ 4.6 Glutamine transport ATP-binding protein ns SAOUHSC_02557 yut 4.5 Putative urea transporter ns SAOUHSC_01949 epiP 4.4 Intracellular serine protease ns SAOUHSC_00120 capG 4.4 UDP-N-acetylglucosamine 2-epimerase ns SAOUHSC_01952 bsaB 4.4...”
- The Staphylococcus aureus KdpDE two-component system couples extracellular K+ sensing and Agr signaling to infection programming
Xue, Infection and immunity 2011 - “...genes SAOUHSC_01385 SAOUHSC_01386 SAOUHSC_02311 SAOUHSC_02310 SAOUHSC_01990 SAOUHSC_00636 SAOUHSC_00637 SAOUHSC_02661 PstB product phosphate ABC transporter...”
- The Staphylococcus aureus GGDEF domain-containing protein, GdpS, influences protein A gene expression in a cyclic diguanylic acid-independent manner
Shang, Infection and immunity 2009 - “...SAOUHSC_00009 SAOUHSC_02552 SAOUHSC_02558 SAOUHSC_02561 SAOUHSC_01990 SAOUHSC_02711 SAOUHSC_02712 SAOUHSC_02713 SAOUHSC_02714 SAOUHSC_02715 SAOUHSC_02716...”
- Identification of the main glutamine and glutamate transporters in Staphylococcus aureus and their impact on c-di-AMP production
Zeden, Molecular microbiology 2020 - “...transport in other bacteria (SchuurmanWolters & Poolman, 2005 ). S. aureus contains a glnPQ (SAUSA300_1808 SAUSA300_1807) operon with glnP coding for a substratebinding domainpermease fusion protein and glnQ coding for the cytoplasmic nucleotidebinding ATPase domain. The results from a previous study suggested that this transporter functions...”
- Sulfide Homeostasis and Nitroxyl Intersect via Formation of Reactive Sulfur Species in Staphylococcus aureus
Peng, mSphere 2017 - “...SA1003 3.4 Hypothetical (fibrinogen binding) NWMN_1070 SA1004 6.9 Hypothetical (fibrinogen binding) NWMN_1352 SA1275 5.0 Hypothetical NWMN_1749 SA1674 tcyC 1.8 e 7.1 ABC transporter: cystine (ATPase) e + Down NWMN_1750 SA1675 tycB 1.6 e 6.7 ABC transporter: cystine (permease) e + Down NWMN_1751 SA1676 tycA 1.2 e...”
- “...addition, the expression levels of genes encoding methionine (NWMN_0246 to NWMN_0428) and cystine (NWMN_0374 and NWMN_1749 to NWMN_1751) ABC transporters and an operon (NWMN_1951 to NWMN_1952) encoding a TusA-like sulfurtransferase and a putative thiosulfate importer are also repressed ( 3 ). Loss of cymR in a...”
- Inactivation of the Ecs ABC transporter of Staphylococcus aureus attenuates virulence by altering composition and function of bacterial wall
Jonsson, PloS one 2010 - “...permease 0.5 NWMN_1540 preprotein translocase YajC subunit 2.7 NWMN_1728 ABC transporter ATP-binding protein 2.2 7.0 NWMN_1749 amino acid ABC transporter ATP-binding protein 3.1 NWMN_1763 ABC transporter ATP-binding protein 2.1 NWMN_1867 ABC transporter ATP-binding protein 1.8 NWMN_1950 ammonium transporter 0.4 NWMN_2050 cation efflux 0.5 0.5 NWMN_2076 FecCD...”
- CodY in Staphylococcus aureus: a regulatory link between metabolism and virulence gene expression
Pohl, Journal of bacteriology 2009 - “...NWMN_1308 NWMN_1311 NWMN_1348 NWMN_1616 NWMN_1617 NWMN_1749 NWMN_1750 NWMN_1960 NWMN_1961 NWMN_1962 NWMN_1963 NWMN_1964 NWMN_1965 NWMN_1966 NWMN_2347 NWMN_2500...”
PSPTO_3882 polyamine ABC transporter, ATP-binding protein, putative from Pseudomonas syringae pv. tomato str. DC3000
29% identity, 70% coverage
- Identification of Indole-3-Acetic Acid-Regulated Genes in Pseudomonas syringae pv. tomato Strain DC3000
Djami-Tchatchou, Journal of bacteriology 2022 (secret) - Predicting genome-scale Arabidopsis-Pseudomonas syringae interactome using domain and interolog-based approaches
Sahu, BMC bioinformatics 2014 - “...also several effectors with more than 40 predicted PPIs. These are PSPTO_4497, PSPTO_1482, PSPTO_4868, PSPTO_4602, PSPTO_3882, PSPTO_0405, PSPTO_1492, PSPTO_4093, PSPTO_1949, PSPTO_4776, PSPTO_3130, PSPTO_3900, PSPTO_5014 and PSPTO_4090. In contrast to these hub proteins, several effectors are predicted to interact with very few proteins. These hub proteins play...”
4ymuJ / Q8RCC2 Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
Q8RCC2 ABC-type polar amino acid transport system, ATPase component from Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4)
30% identity, 87% coverage
SPD_0616 amino acid ABC transporter, ATP-binding protein from Streptococcus pneumoniae D39
DQM66_RS03315 amino acid ABC transporter ATP-binding protein from Streptococcus pneumoniae
29% identity, 89% coverage
- The five homologous CiaR-controlled Ccn sRNAs of Streptococcus pneumoniae modulate Zn-resistance
De, PLoS pathogens 2024 - “...5.65 SPD_0503 bglA-2 6-phospho--glucosidase 2.57 4.79 SPD_0615 glnH3 degenerate glutamine ABC transporter subunit 11.6 4.05 SPD_0616 glnQ3 glutamine ABC transporter subunit 8.90 3.07 SPD_0617 glnP3b glutamine ABC transporter subunit 11.1 3.63 SPD_0618 glnP3a glutamine ABC transporter subunit 11.8 2.98 SPD_0775 acetyltransferase 3.29 2.71 SPD_1045 degenerate DUF3884...”
- “...SPD_0537 putative Zn-dependent protease 2.07 2.21 SPD_0615 glnH3 degenerate glutamine ABC transporter subunit 11.6 18.0 SPD_0616 glnQ3 glutamine ABC transporter subunit 8.90 16.8 SPD_0617 glnP3b glutamine ABC transporter subunit 11.1 15.8 SPD_0618 glnP3a glutamine ABC transporter subunit 11.8 15.1 SPD_0681 hypothetical protein 2.82 5.45 SPD_0701 ciaR...”
- Deletion of the Zinc Transporter Lipoprotein AdcAII Causes Hyperencapsulation of Streptococcus pneumoniae Associated with Distinct Alleles of the Type I Restriction-Modification System
Durmort, mBio 2020 - “...transporter, ATP-binding protein 1.76 1.77 1.11 SPD_0615 ABC transporter substrate binding protein 1.51 2.25 1.25 SPD_0616 glnQ Amino acid ABC transporter ATPase 1.56 2.38 1.13 SPD_0617 glnP Amino acid ABC transporter permease 1.76 2.64 1.25 SPD_0618 glnP Amino acid ABC transporter permease 1.71 2.51 1.20 SPD_0851...”
- Cysteine-Mediated Gene Expression and Characterization of the CmbR Regulon in Streptococcus pneumoniae
Afzal, Frontiers in microbiology 2016 - “...transporter, amino acid-binding protein, putative, GshT 4.8 spd_0615 ABC transporter substrate-binding protein, authentic truncation 3.2 spd_0616 Amino acid ABC transporter, ATP-binding protein 1.9 spd_0617 Amino acid ABC transporter, permease protein 2.0 spd_0618 Amino acid ABC transporter, permease protein 1.6 spd_1073 O -acetylhomoserine aminocarboxypropyltransferase/cysteine synthase 1.6 spd_1074...”
- Ni2+-Dependent and PsaR-Mediated Regulation of the Virulence Genes pcpA, psaBCA, and prtA in Streptococcus pneumoniae
Manzoor, PloS one 2015 - “...CDM with 0.3 mM Ni 2+ . Gene tag a Function b Ratio c P-value spd_0616 Amino acid ABC transporter, ATP-binding protein -4.40 1.32E-05 spd_0617 Amino acid ABC transporter, permease protein -5.99 7.46E-07 spd_0618 Amino acid ABC transporter, permease protein -6.19 4.27E-07 spd_0558 Cell wall-associated serine...”
- Influence of Streptococcus pneumoniae Within-Strain Population Diversity on Virulence and Pathogenesis
Jacques, Microbiology spectrum 2023 - “...factor G 319145 A454V DQM66_RS01735 Sugar transferase 342683 A109V pbp1a Penicillin-binding protein PBP1A 638380 I218V DQM66_RS03315 Amino acid ABC transporter ATP-binding protein 735779 V86I DQM66_RS03875 Amino acid ABC transporter ATP-binding protein 753387 G437D DQM66_RS03985 ABC transporter ATP-binding protein 962360 R85C rpmA 50S ribosomal protein L27 1632521...”
plu4040 Probable ABC transporter ATP-binding protein yhbG from Photorhabdus luminescens subsp. laumondii TTO1
28% identity, 80% coverage
Atu3744 ABC transporter, nucleotide binding/ATPase protein from Agrobacterium tumefaciens str. C58 (Cereon)
A9CFL3 ABC transporter, nucleotide binding/ATPase protein from Agrobacterium fabrum (strain C58 / ATCC 33970)
30% identity, 36% coverage
- Agrobacterium tumefaciens Type IV and Type VI Secretion Systems Reside in Detergent-Resistant Membranes
Czolkoss, Frontiers in microbiology 2021 - “...atu1034 A9CJK6 Signal peptidase I DRM only 0.002 Atu3773 atu3773 A9CFM6 Unknown DRM only 0.234 Atu3744 (MsbA) atu3744 A9CFL3 ABC transporter, nucleotide binding/ATPase protein DRM only 0.037 LptD atu1106 A9CJH2 LPS-assembly protein LptD DRM only 0.076 Atu2749 (LptE) atu2749 A9CHE8 LPS-assembly lipoprotein LptE DRM only 0.088...”
- “...to the outer leaflet of the outer membrane ( Okuda et al., 2016 ). MsbA (Atu3744) belongs to the A. tumefaciens DRM proteome in complex and minimal medium ( Table 1 and Supplementary Table 3 ). Interestingly, each of the Lpt proteins spanning the inner membrane...”
- Agrobacterium tumefaciens Type IV and Type VI Secretion Systems Reside in Detergent-Resistant Membranes
Czolkoss, Frontiers in microbiology 2021 - “...peptidase I DRM only 0.002 Atu3773 atu3773 A9CFM6 Unknown DRM only 0.234 Atu3744 (MsbA) atu3744 A9CFL3 ABC transporter, nucleotide binding/ATPase protein DRM only 0.037 LptD atu1106 A9CJH2 LPS-assembly protein LptD DRM only 0.076 Atu2749 (LptE) atu2749 A9CHE8 LPS-assembly lipoprotein LptE DRM only 0.088 Atu3203 atu3203 Q7CRV9...”
NGR_c00180 LPS export ABC transporter ATP-binding protein from Sinorhizobium fredii NGR234
29% identity, 81% coverage
XP_008260013 ATP-dependent translocase ABCB1 isoform X3 from Oryctolagus cuniculus
30% identity, 16% coverage
NGR_c00180 predicted ABC transporter, ATP-binding protein from Rhizobium sp. NGR234
29% identity, 80% coverage
MDR1_ASPFU / Q4WTT9 ABC multidrug transporter mdr1 from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata) (see 5 papers)
AFUA_5G06070 ABC multidrug transporter Mdr1 from Aspergillus fumigatus Af293
31% identity, 16% coverage
- function: Pleiotropic ABC efflux transporter that may be involved in A.fumigatus adaptation to azoles such as vorizonazole.
catalytic activity: voriconazole(in) + ATP + H2O = voriconazole(out) + ADP + phosphate + H(+) (RHEA:61912) - Identifying Potential Molecular Targets in Fungi Based on (Dis)Similarities in Binding Site Architecture with Proteins of the Human Pharmacolome
Bedoya-Cardona, Molecules (Basel, Switzerland) 2023 - “...Q4WHZ1 97 A0A1D8PD39 100 G8B666 100 Q5KEN6 93 A0A0D2XPE5 97 P-glycoprotein 1 P08183 F0UGI7 93 Q4WTT9 87 Q5KN49 87 A0A0D2XVG0 80 IMP dehydrogenase 2 P12268 F0UKI1 93 Q4WHZ9 93 Q59Q46 97 G8B7I7 97 Q5KP44 97 A0A0D2XAA8 93 FPP synthase P14324 F0UP55 91 Q4WEB8 91 A0A1D8PH78 91...”
- Genome-Wide Association Analysis for Triazole Resistance in Aspergillus fumigatus
Fan, Pathogens (Basel, Switzerland) 2021 - “...~1.00 ~2.00>20.00 [ 25 , 38 ] atrF (AFUA_6G04360) 31.7 NA [ 25 ] mdr1 (AFUA_5G06070) ~5.00 ~2.005.00 [ 25 , 38 ] mdr4 (AFUA_1G12690) ~4.70 NA [ 25 ] AFUA_5G02260 ABC multidrug transporter, putative ~4.90 NA [ 25 ] AFUA_2G11580 MFS multidrug transporter, putative 14.2...”
- Differentially Regulated Transcription Factors and ABC Transporters in a Mitochondrial Dynamics Mutant Can Alter Azole Susceptibility of Aspergillus fumigatus
Sturm, Frontiers in microbiology 2020 - “...mdd5 tetOn (AFUA_6G12160), mdd6 tetOn (AFUA_4G06880), abc1 tetOn (AFUA_3G01400), mdr1 tetOn ( abc2 tetOn ; AFUA_5G06070), abc3 tetOn (AFUA_6G08020), abc4 tetOn (AFUA_4G14130), abc5 tetOn (AFUA_6G03080), abc6 tetOn (AFUA_5G10510), and abc7 tetOn (AFUA_3G07300) were constructed by inserting a doxycycline-inducible promoter cassette (oliC-tetOn; pJW128) before the coding regions...”
- “...mutants of the differentially regulated ABC transporters ( Figure 3D and Supplementary Table S14 ). AFUA_5G06070 ( abc2 ) was already denominated mdr1 in current genome databases, and the respective name was used for consistency. To this end, a well-established doxycycline-inducible Tet-On promoter system was applied...”
- Trichophyton rubrum Azole Resistance Mediated by a New ABC Transporter, TruMDR3
Monod, Antimicrobial agents and chemotherapy 2019 - “...in the three pathogenic fungi used for identification ( Table 2 ). A. fumigatus mdr1/abcA (AFUA_5G06070) alone led to the identification of six different potential transporters of T. rubrum . TABLE 2 Identification of potential T. rubrum ABC transporters involved in azole resistance Locus name by...”
- “...76 ), 23796749 ( 77 ) TERG_02186 (TruMDR3) , TERG_02508 (TruMDR1) 71.5, 1,085; 50.8, 1,404 AFUA_5G06070 mdr1/abcA VRC induced 16622700 ( 22 ) TERG_08613 (TruMDR2) , TERG_08693, TERG_00402, TERG_08751, TERG_04952 (TruMDR5) , TERG_08591 68.5, 1,318; 50.1, 1,032; 49.1, 434; 41.7, 1,349; 40.7, 995; 38.7, 1,349 AFUA_6G03470...”
- Mitochondrial Complex I Is a Global Regulator of Secondary Metabolism, Virulence and Azole Sensitivity in Fungi
Bromley, PloS one 2016 (no snippet) - A proteomic approach to investigating gene cluster expression and secondary metabolite functionality in Aspergillus fumigatus
Owens, PloS one 2014 - “...+ -ATPase (AFUA_3G07640), an amino acid permease (Gap1) (AFUA_7G04290) and two ABC transporters (AFUA_1G14330 and AFUA_5G06070). One protein, a small oligopeptide transporter (OPT family) (AFUA_2G15240) was detected with 14 putative transmembrane regions and a GRAVY score of 0.276. Annotations were available for 89.37%, 86.47% and 49.27%...”
- Heptahelical receptors GprC and GprD of Aspergillus fumigatus Are essential regulators of colony growth, hyphal morphogenesis, and virulence
Gehrke, Applied and environmental microbiology 2010 - “...AFUA_3G01580 AFUA_5G11245 AFUA_1G10370 AFUA_5G14810 AFUA_5G06070 AFUA_4G09060 AFUA_5G13710 AFUA_3G11070 -Glucosidase C6 transcription factor Methionine...”
TC 3.A.1.201.10 / B0Y3B6 Mdr1; resistance to Cilofungin and other drugs from Aspergillus fumigatus (strain CEA10 / CBS 144.89 / FGSC A1163) (see paper)
31% identity, 16% coverage
XAC2971 ABC transporter ATP-binding protein from Xanthomonas axonopodis pv. citri str. 306
29% identity, 83% coverage
PF1654 similar to ABC transporter (ATP-binding protein) from Pyrococcus furiosus DSM 3638
32% identity, 37% coverage
lptB / O25417 lipopolysaccharide transport system ATP-binding protein LptB (EC 7.5.2.5) from Helicobacter pylori (strain ATCC 700392 / 26695) (see paper)
HPG27_671 ABC transporter. ATP-binding protein from Helicobacter pylori G27
HP0715 ABC transporter, ATP-binding protein from Helicobacter pylori 26695
HPG27_RS03465, HPYLSS1_00622 LPS export ABC transporter ATP-binding protein from Helicobacter pylori G27
29% identity, 90% coverage
- Genetic requirements and transcriptomics of Helicobacter pylori biofilm formation on abiotic and biotic surfaces
Hathroubi, NPJ biofilms and microbiomes 2020 - “...D 3.57 HPG27_1059 Hypothetical protein 3.53 HPG27_335 Hypothetical protein 3.39 HPG27_269 LysA, diaminopimelate decarboxylase 3.29 HPG27_671 LptB, ABC transporter 3.26 HPG27_506 CagB, cag island protein B 3.18 HPG27_271 Hypothetical protein 3.17 HPG27_442 m5 C methyltransferase 3.15 HPG27_834 Hypothetical protein 3.13 HPG27_669 Hypothetical protein 3.06 HPG27_1331 Hypothetical...”
- Identification of an Essential LolD-Like Protein in Helicobacter pylori
McClain, Journal of bacteriology 2023 (secret) - Helicobacter pylori Modulates Heptose Metabolite Biosynthesis and Heptose-Dependent Innate Immune Host Cell Activation by Multiple Mechanisms
Hauke, Microbiology spectrum 2023 - “...) 333.82 1.77 3.42 4.91E10 HP0603 80.49 1.86 3.64 2.29E03 HP0629 54.18 0.95 1.94 8.87E05 HP0715 556.56 1.71 3.27 0 HP0751 ( flaG ) 1,284.04 2.40 5.29 0 HP0752 ( fliD ) 688.1 1.59 3.01 0 HP0753 ( fliS ) 270.58 0.87 1.82 4.53E04 HP0754 125.88...”
- AI-2 Induces Urease Expression Through Downregulation of Orphan Response Regulator HP1021 in Helicobacter pylori
Yang, Frontiers in medicine 2022 - “...1.8017 HPt01 tRNA-Glu 1.8654 HP0107 Cysteine synthetase CysK 1.8681 HP0714 RNA polymerase factor sigma-54 1.869 HP0715 ABC transporter ATP-binding protein 1.9132 HP0039 Pseudogene 1.9381 HP1080 Restriction endonuclease 1.9476 HP1051 Hypothetical protein 1.9653 HP0998 IS605 family transposase TnpA 1.9908 HP0603 Hypothetical protein 2.0065 HP0682 Hypothetical protein 2.0177...”
- High-Salt Conditions Alter Transcription of Helicobacter pylori Genes Encoding Outer Membrane Proteins
Loh, Infection and immunity 2018 - “...HPB8_1146 HPB8_1238 HP0601 HP0630 HP0641 HP0641 HP0642 HP0715 HP0719/720 HP0731 HP0733 HP0751 HP0802 HP0807 HP0808 HP0812 HP0815 HP0851 HP0474 HP0472 HP0463...”
- The Helicobacter pylori J99 jhp0106 Gene, under the Control of the CsrA/RpoN Regulatory System, Modulates Flagella Formation and Motility
Kao, Frontiers in microbiology 2017 - “...** /2.28 jhp0529 ( tonB ) HP0582 Siderophore-mediated iron transport protein 3.22 *** /3.24 jhp0653 HP0715 ABC transporter, ATP-binding protein 3.22 *** /3.72 jhp0743 ( fecA ) HP0807 Iron (III) dicitrate transport protein 1.75 ns /3.37 CELL SURFACE STRUCTURE jhp0373 ( lpxC ) HP1052 UDP-3-O-hydroxymyristoyl 2.72...”
- Structural and functional aspects of the Helicobacter pylori secretome
Zanotti, World journal of gastroenterology 2014 - “...biogenesis complex components Label HP0785 HP0787 HP1568 HP0715 HP1569 HP1216 HP1546 HP0362 HP1498 HP1082 HP0655 HP1378 HP0786 HP1300 HP1203 HP1255 HP1550...”
- Outer membrane biogenesis in Escherichia coli, Neisseria meningitidis, and Helicobacter pylori: paradigm deviations in H. pylori
Liechti, Frontiers in cellular and infection microbiology 2012 - “...lolE 4e 25 24%/49% Integral membrane protein Lpt COMPLEX HP1568 lptA *** *** Periplasmic chaperone HP0715 lptB 3e 90 55%/75% IM ABC transporter domain HP1569 lptC ns. ns. IM associated lipoprotein HP1216 lptD 2e 08 26%/49% OM LPS transport protein HP1546 lptE ns. ns. OM associated...”
- “...the integral membrane proteins MsbA, LptB, and LptD (Table 1 ). The encoding genes (HP1082, HP0715, and HP1215/1216, respectively) are present in all sequenced H. pylori isolates available (strains 26695, J99, HPAG1) as well as Helicobacter acinonychis and Campylobacter jejuni and are highly conserved when compared...”
- pH-regulated gene expression of the gastric pathogen Helicobacter pylori
Merrell, Infection and immunity 2003 - “...Unknown function TIGR ASTRA HP0471 HP1339 HP1340 HP0876 HP0715 HP1432 JHP0423 JHP1258 JHP1259 JHP0810 JHP0653 JHP1321 HP1465 JHP1358 HP1038 HP0695 HP0722 HP0638...”
- More
- Phillygenin Inhibits Helicobacter pylori by Preventing Biofilm Formation and Inducing ATP Leakage
Li, Frontiers in microbiology 2022 - “...LTAsynthasefamilyprotein The sulfuric ester hydrolase activity flagellinA HPG27_RS02925 4.0196 FlagellinA The two-component system/Flagellar assembly lptB HPG27_RS03465 5.3738 LPSexportABCtransporterATP-bindingprotein The ABC transporters Discussion Helicobacter pylori is a cause for the occurrence of various intestinal and extra-intestinal diseases and severe drug resistance (Sugano et al., 2015 ; Okuda...”
- Helicobacter pylori Biofilm Involves a Multigene Stress-Biased Response, Including a Structural Role for Flagella
Hathroubi, mBio 2018 - “...2.14 fliD (HPYLSS1_00585) Flagellar hook-associated protein 2 2 lpxB (HPYLSS1_00467) Lipid A-disaccharide synthase 3.06 lptB (HPYLSS1_00622) Lipopolysaccharide export system ATP-binding 2.54 mltD (HPYLSS1_01517) Membrane-bound lytic murein transglycosylase D precursor 2 pgdA (HPYLSS1_00299) Peptidoglycan deacetylase 2.1 HPYLSS1_00450 Membrane protein 3.78 HPYLSS1_01378 Outer membrane protein homD 3.26 HPYLSS1_01113...”
XP_004079446 ATP-binding cassette sub-family B member 8, mitochondrial from Oryzias latipes
32% identity, 33% coverage
7qkrA / F2QQK6 Cryo-em structure of abc transporter ste6-2p from pichia pastoris with verapamil at 3.2 a resolution (see paper)
33% identity, 18% coverage
- Ligands: dexverapamil; phosphoaminophosphonic acid-adenylate ester; (3beta,14beta,17beta,25r)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en (7qkrA)
XP_006779228 multidrug resistance protein 1 from Myotis davidii
32% identity, 18% coverage
Q835Z8 Spermidine/putrescine ABC transporter, ATP-binding protein from Enterococcus faecalis (strain ATCC 700802 / V583)
27% identity, 73% coverage
- Gliotoxin-mediated bacterial growth inhibition is caused by specific metal ion depletion
Downes, Scientific reports 2023 - “...ATPase 0.938649 0.0166494 17 29.1 Q838Y5 Spermidine/putrescine ABC transporter, ATP-binding protein 0.935763 0.0242974 2 6.9 Q835Z8 Cold shock protein CspC 0.826335 0.0414736 4 80.3 Q833G3 Cellulose biosynthesis cyclic di-GMP-binding regulatory protein BcsB 0.809572 0.0170368 12 23 Q837F4 DUF2187 domain-containing protein 0.75339 0.0432523 3 63.8 Q835R0 Segregation...”
lptB / Q2YP14 lipopolysaccharide transport system ATP-binding protein (EC 7.5.2.5) from Brucella abortus (strain 2308) (see paper)
BCAN_A0162 Probable ABC transporter ATP-binding protein in ntrA/rpoN 5'region from Brucella canis ATCC 23365
BMEI1790 ABC TRANSPORTER ATP-BINDING PROTEIN from Brucella melitensis 16M
28% identity, 79% coverage
- ATP-Binding Cassette Systems of Brucella
Jenner, Comparative and functional genomics 2009 - “...BOV_1063 BCAN_A1124 97 YHBG Possible LPS transport to outer membrane ABC BMEI1790 BruAb10153 BR157 BOV_0152 BCAN_A0162 YHBG Possible LPS transport to outer membrane SS BMEI1791 BruAb10152 BR156 BOV_0151 BCAN_A0161 ABC: ATP-Binding Cassette; IM: Inner membrane protein; BP: Binding protein; IM-ABC: Inner membrane protein-ATP binding cassette fusion;...”
- ATP-Binding Cassette Systems of Brucella
Jenner, Comparative and functional genomics 2009 - “...BMEI0878 BruAb1110, UvrA UvrA BOV_1063 BCAN_A1124 97 YHBG Possible LPS transport to outer membrane ABC BMEI1790 BruAb10153 BR157 BOV_0152 BCAN_A0162 YHBG Possible LPS transport to outer membrane SS BMEI1791 BruAb10152 BR156 BOV_0151 BCAN_A0161 ABC: ATP-Binding Cassette; IM: Inner membrane protein; BP: Binding protein; IM-ABC: Inner membrane...”
TC 3.A.1.201.12 / B2WTH9 California mussel ABCB/MDR multixenobiotic resistance efflux pump from Mytilus californianus (see paper)
30% identity, 17% coverage
LLNZ_01800 ABC transporter ATP-binding protein from Lactococcus cremoris subsp. cremoris NZ9000
31% identity, 43% coverage
ZMO0275 ABC transporter related protein from Zymomonas mobilis subsp. mobilis ZM4
28% identity, 87% coverage
BOV_0152 ABC transporter, ATP-binding protein from Brucella ovis ATCC 25840
28% identity, 86% coverage
- ATP-Binding Cassette Systems of Brucella
Jenner, Comparative and functional genomics 2009 - “...UvrA BOV_1063 BCAN_A1124 97 YHBG Possible LPS transport to outer membrane ABC BMEI1790 BruAb10153 BR157 BOV_0152 BCAN_A0162 YHBG Possible LPS transport to outer membrane SS BMEI1791 BruAb10152 BR156 BOV_0151 BCAN_A0161 ABC: ATP-Binding Cassette; IM: Inner membrane protein; BP: Binding protein; IM-ABC: Inner membrane protein-ATP binding cassette...”
Athe_1109 ABC transporter related from Anaerocellum thermophilum DSM 6725
Athe_1109 ABC transporter ATP-binding protein from Caldicellulosiruptor bescii DSM 6725
31% identity, 66% coverage
cg2939 ABC-type dipeptide/oligopeptide/nickel transport system, fused permease and ATPase components from Corynebacterium glutamicum ATCC 13032
28% identity, 34% coverage
V089_02512 SAV1866 family putative multidrug efflux ABC transporter from Staphylococcus aureus GD2010-115
31% identity, 40% coverage
- An Educational Bioinformatics Project to Improve Genome Annotation
Amatore, Frontiers in microbiology 2020 - “...HPs with lesser similarity (W538_02582 from S. aureus VET0261R, W475_02351 from S. aureus VET0166R, and V089_02512 from S. aureus GD2010-115). We noted that AUH26_00140 was not included in the UniProt knowledgebase. The 592-amino acid sequence for AUH26_00140 is below: >OLC18526.1 hypothetical protein AUH26_00140 [ Candidatus Rokubacteria...”
HP1171 glutamine ABC transporter, ATP-binding protein (glnQ) from Helicobacter pylori 26695
28% identity, 84% coverage
- Identification of an Essential LolD-Like Protein in Helicobacter pylori
McClain, Journal of bacteriology 2023 (secret) - Delineation of the pH-Responsive Regulon Controlled by the Helicobacter pylori ArsRS Two-Component System
Loh, Infection and immunity 2021 (secret) - Discovery of novel mutations for clarithromycin resistance in Helicobacter pylori by using next-generation sequencing
Binh, The Journal of antimicrobial chemotherapy 2014 - “...On the other hand, one point mutation (A571G) in hp1171, which encodes a glutamine ABC transporter ATP-binding protein, was found in strain 26695-1CH. A 3 bp...”
- “...mutations in six genes (hp0190, kefB, acrB, infB, hp1171 and rpl22) outside the 23S rRNA genes were involved in clarithromycin resistance, we performed natural...”
- pH-regulated gene expression of the gastric pathogen Helicobacter pylori
Merrell, Infection and immunity 2003 - “...HP0278 JHP0403 JHP0263 HP0550 HP1203 HP0123 HP1019 HP1171 HP1172 JHP0497 JHP1126 JHP0113 JHP0405 JHP1098 JHP1099 JHP0110 JHP1247 JHP1113 JHP0349 JHP0205 JHP1100...”
W475_02351 SAV1866 family putative multidrug efflux ABC transporter from Staphylococcus aureus VET0166R
31% identity, 39% coverage
- An Educational Bioinformatics Project to Improve Genome Annotation
Amatore, Frontiers in microbiology 2020 - “...10 142 ) over three other HPs with lesser similarity (W538_02582 from S. aureus VET0261R, W475_02351 from S. aureus VET0166R, and V089_02512 from S. aureus GD2010-115). We noted that AUH26_00140 was not included in the UniProt knowledgebase. The 592-amino acid sequence for AUH26_00140 is below: >OLC18526.1...”
Ssal_01465 ABC transporter ATP-binding protein from Streptococcus salivarius 57.I
32% identity, 68% coverage
YEJF_AGRFC / A9CKL2 Peptidoglycan transport ATP-binding protein YejF; EC 7.4.2.- from Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58)) (see paper)
Atu0190 ABC transporter, nucleotide binding/ATPase protein (peptide) from Agrobacterium tumefaciens str. C58 (Cereon)
27% identity, 40% coverage
- function: Part of the ABC transporter complex YejBEF-YepA involved in the uptake of muropeptides, the breakdown products of cell wall peptidoglycan (PubMed:36566216). The import of muropeptides into the cell enables peptidoglycan recycling, which is vital for cell wall integrity in this bacterium (PubMed:36566216). Is also probably part of the ABC transporter complex YejABEF, which is likely involved in broad- spectrum peptide import (Probable). Responsible for energy coupling to the transport system (Probable).
subunit: The complex is composed of one ATP-binding protein (YejF), two transmembrane proteins (YejB and YejE) and a solute-binding protein (YepA or YejA).
disruption phenotype: The deletion mutant is hypersensitive to ampicillin, in a manner only partly dependent on the beta-lactamase AmpC (PubMed:36566216). Deletion of the yejABEF operon leads to the accumulation of anhydromuramyl tri-, tetra- and pentapeptides in large quantities in the extracellular milieu (PubMed:36566216). The yejABEF mutant displays cell swelling and lysis as well as a severe growth defect (PubMed:36566216). - Peptidoglycan recycling mediated by an ABC transporter in the plant pathogen Agrobacterium tumefaciens
Gilmore, Nature communications 2022 - “...consisting of two membrane-spanning proteins yejB and yejE (Atu0188 and Atu0189) and an ATPase yejF (Atu0190). Interestingly, these genes form an operon with a periplasmic SBP, yejA (Atu0187) which was not affected in Tn insertions under Fosfomycin treatment. Instead, our screen identified an alternative peptide-binding SBP...”
BL105A_0547 amino acid ABC transporter ATP-binding protein from Bifidobacterium longum
29% identity, 77% coverage
- Application of Recombinase-Based In Vivo Expression Technology to Bifidobacterium longum subsp. longum for Identification of Genes Induced in the Gastrointestinal Tract of Mice
Koguchi, Microorganisms 2020 - “...analysis to verify in vivo-specific expression: BL105A_0130 (presumable pilin subunit for Tad-pili), BL105A_0467 (putative adhesin), BL105A_0547 (ATPase of the ABC transporter), BL105A_1291 (serine protease inhibitor), BL105A_1293 (galactoside transport protein), BL105A_1294 (glycoside hydrolase family 32 -fructofuranosidase), BL105A_1798 (putative glycosyltransferase), and BL105A_1894 (raffinose transport system permease protein). Among...”
- “...BL105A_1291, and BL105A_1293) showed significantly increased expression in the cecum, but the other three genes (BL105A_0547, BL105A_1798, and BL105A_1894) did not ( Figure 4 ). Although this inconsistency might be attributed to that different mice were used between these two assays, there are some other possible...”
W538_02582 SAV1866 family putative multidrug efflux ABC transporter from Staphylococcus aureus VET0261R
31% identity, 38% coverage
- An Educational Bioinformatics Project to Improve Genome Annotation
Amatore, Frontiers in microbiology 2020 - “...identity, E -value = 6.0 10 142 ) over three other HPs with lesser similarity (W538_02582 from S. aureus VET0261R, W475_02351 from S. aureus VET0166R, and V089_02512 from S. aureus GD2010-115). We noted that AUH26_00140 was not included in the UniProt knowledgebase. The 592-amino acid sequence...”
Y1866_STAAM / Q99T13 Putative multidrug export ATP-binding/permease protein SAV1866; EC 7.6.2.- from Staphylococcus aureus (strain Mu50 / ATCC 700699) (see paper)
Q99T13 ABC-type xenobiotic transporter (EC 7.6.2.2) from Staphylococcus aureus (see paper)
TC 3.A.1.106.2 / Q2G2M9 The homodimeric Sav1866 multidrug exporter (transports doxorubicin, verapamil, ethidium, tetraphenylphosphonium, vinblastine and the fluorescent dye, Hoechst 33342; 3-D structure known at 3 Å resolution; Dawson and Locher, 2006; Velamakanni et al., 2008) The empty site opens by rotation of the nucleotide-binding domain whereas the ATP-bound site remains occluded (Jones and George, 2011). Conformational changes induced by ATP-binding and hydrolysis have been proposed (Becker et al. 2010; Oliveira et al., 2011). The alternating access mechanism and the flippase activity of this ABC exporter has been shown to be lipid-dependent (Becker et al. 2010; Oliveira et al., 2011). The alternating access mechanism and the flippase activity of this ABC exporter has been shown to be lipid-dependent from Staphylococcus aureus (strain NCTC 8325)
2hydA / Q99T13 Multidrug abc transporter sav1866 (see paper)
SAOUHSC_02003 ABC transporter, ATP-binding/permease protein, putative from Staphylococcus aureus subsp. aureus NCTC 8325
SAAV_1916 toxin exporting ABC transporter, permease from Staphylococcus aureus subsp. aureus ED98
SAV1866 ABC transporter homolog from Staphylococcus aureus subsp. aureus Mu50
NWMN_1758 ABC transporter ATP-binding protein from Staphylococcus aureus subsp. aureus str. Newman
SACOL1924 toxin exporting ABC transporter, permease/ATP-binding protein, putative from Staphylococcus aureus subsp. aureus COL
31% identity, 38% coverage
- function: May be involved in multidrug export. Transmembrane domains (TMD) form a pore in the cell membrane and the ATP-binding domain (NBD) is responsible for energy generation.
subunit: Homodimer. - substrates: Hoechst 3342, doxorubicin, ethidium, tetraphenylphosphonium, verapamil, vinblastine
- Ligand: adenosine-5'-diphosphate (2hydA)
- Exploring the targetome of IsrR, an iron-regulated sRNA controlling the synthesis of iron-containing proteins in Staphylococcus aureus
Ganske, Frontiers in microbiology 2024 - “...FadE (SAOUHSC_00198) exp: 1.2 (1.0e+00) stat: 1.5 (6.5e04) exp: 1.6 (2.1e01) stat: 2.1 (7.4e15) X SAOUHSC_02003 exp: 2.2 (6.4e04) stat: 15.7 (4.8e07) exp: 2.4 (6.9e02) stat: 3.3 (6.6e08) X SAOUHSC_02760 exp: 1.5 (2.6e01) stat: 2.0 (2.3e06) exp: 1.7 (1.1e01) stat: 1.9 (2.0e10) X HemA (SAOUHSC_01776) exp:...”
- Clemastine Inhibits the Biofilm and Hemolytic of Staphylococcus aureus through the GdpP Protein
Shang, Microbiology spectrum 2022 - “...UreE UreC 0.42 Urease subunit alpha UreG 0.50 Urease accessory protein UreG ATP binding protein SAOUHSC_02003 0.49 Putative multidrug export ATP-binding/permease protein SAOUHSC_02003 PhnC 0.17 Phphonates import ATP-binding protein PhnC SAOUHSC_01990 0.10 Amino acid ABC transporter, ATP-binding protein, putative SAOUHSC_02397 0.14 ABC transporter, ATP-binding protein, putative...”
- Pseudomonas aeruginosa PA14 Enhances the Efficacy of Norfloxacin against Staphylococcus aureus Newman Biofilms
Orazi, Journal of bacteriology 2020 (secret) - 'Ca. Liberibacter asiaticus' proteins orthologous with pSymA-encoded proteins of Sinorhizobium meliloti: hypothetical roles in plant host interaction
Kuykendall, PloS one 2012 - “...binding/ATPase, was homologous with Q2G2M9 (4.00E-088), a putative multi-drug export ATP-binding/permease protein of Staphylococcus aureus, SAOUHSC_02003. Like YP_003065157, YP_003065330 aligns best with nodI NP_435718.1 (2.00E-021) encoded by pSymA . Ca . Liberibacter asiaticus YP_003065113, orthologous to pSymA-encoded protein NP_435856.2 (E=5e-33), a serine protease DO protease, has...”
- “...was homologous to Q2G2M9 (4.00E-88), annotated as a putative multi-drug export ATP-binding/permease protein, Staphylococcus aureus SAOUHSC_02003. YP_003065330 aligns best with nodI NP_435718.1 (2.00E-021) encoded by pSymA . Thus these proteins at the least share similar structural motifs. Genes encoding type IV pili may have evolved from...”
- The putative drug efflux systems of the Bacillus cereus group
Hassan, PloS one 2017 - “...The Lipid Exporter (LipidE) Family BC0509 * 100.0 Sav1866 of Staphylococcus aureus Multidrug resistance MC Q2G2M9 3.A.1.106.2 (0); Q8G7R7 3.A.1.106.3 (1e-120); Q9WYC4 3.A.1.135.5 (4e-120) BC0870 * 100.0 YheI of Bacillus subtilis Multidrug resistance MC O07550 3.A.1.106.8 (0); P77265 3. A.1.106.13 (1e-162); A7VN01 3.A.1.106. 5 (2e-154) BC0871...”
- “...3.A.1.106.13 (0); A7VN01 3.A.1.106.5 (0) BC5182 * 97.0 Sav1866 of Staphylococcus aureus Multidrug resistance MC Q2G2M9 3.A.1.106.2 (8e-127); Q8G7R7 3.A.1.106.3 (5e-112); Q9WYC4 3.A.1.135.5 (4e-111) 3.A.1.117: The Drug Exporter-2 (DrugE2) Family BC1955 94.7 BmrA of Bacillus subtilis Multidrug resistance MC O06967 3.A.1.117.3 (0); P97046 3.A.1.117.1 (5e-162); O32748...”
- Bioinformatic analyses of integral membrane transport proteins encoded within the genome of the planctomycetes species, Rhodopirellula baltica.
Paparoditis, Biochimica et biophysica acta 2014 - “...Q7UP62 6 3.A.1.105.3 Q70J76 6 multiple drugs dideacetyl- chromomycin, chromomycin and mithramycin Q7UJF6 6 3.A.1.106.2 Q2G2M9 5 multiple drugs doxorubicin, verapamil, ethidium, tetraphenylphosphoni um, vinblastine and the fluorescent dye Q7ULL7 6 3.A.1.106.2 Q2G2M9 5 multiple drugs doxorubicin, verapamil, ethidium, tetraphenylphosphoni um, vinblastine and the fluorescent dye...”
- 'Ca. Liberibacter asiaticus' proteins orthologous with pSymA-encoded proteins of Sinorhizobium meliloti: hypothetical roles in plant host interaction
Kuykendall, PloS one 2012 - “...Database ( http://www.tcdb.org/ ), YP_003065330, annotated as an ABC-type transporter nucleotide binding/ATPase, was homologous with Q2G2M9 (4.00E-088), a putative multi-drug export ATP-binding/permease protein of Staphylococcus aureus, SAOUHSC_02003. Like YP_003065157, YP_003065330 aligns best with nodI NP_435718.1 (2.00E-021) encoded by pSymA . Ca . Liberibacter asiaticus YP_003065113, orthologous...”
- “...YP_003065330, annotated as an ABC-type transporter with nucleotide binding and ATPase domains was homologous to Q2G2M9 (4.00E-88), annotated as a putative multi-drug export ATP-binding/permease protein, Staphylococcus aureus SAOUHSC_02003. YP_003065330 aligns best with nodI NP_435718.1 (2.00E-021) encoded by pSymA . Thus these proteins at the least share...”
- The Nucleotide-Free State of the Multidrug Resistance ABC Transporter LmrA: Sulfhydryl Cross-Linking Supports a Constant Contact, Head-to-Tail Configuration of the Nucleotide-Binding Domains.
Jones, PloS one 2015 - “...sequences were: LmrA ( L . lactis , Q9CHL8); Sav1866 ( S . aureus , Q99T13); MsbA ( E . coli , P60752); ABCB1 ( H . sapiens , P08183). An automatic CLUSTAL sequence alignment was made of LmrA with Sav1866, V . cholerae MsbA and...”
- Prediction of drug-ABC-transporter interaction--Recent advances and future challenges.
Montanari, Advanced drug delivery reviews 2015 - “...) 3.8 Open-in 2007 Dawson and Locher [ 68 ] 2ONJ S. aureus SAV1866 (Uniprot: Q99T13 ) 3.4 Open-out 2006 Dawson and Locher [ 69 ] 2HYD S. aureus SAV1866 (Uniprot: Q99T13 ) 3.0 Open-out 2007 Ward et al . [ 70 ] 3B5Y , 3B5Z...”
- Localization of putative binding sites for cyclic guanosine monophosphate and the anti-cancer drug 5-fluoro-2'-deoxyuridine-5'-monophosphate on ABCC11 in silico models
Honorat, BMC structural biology 2013 - “...Sequence alignments Primary sequences of human ABCC11 (Q96J66), mouse ABCB1 (P21447) and S. aureus Sav1866 (Q99T13) were downloaded from the Swiss-prot database. Multiple sequence alignment of amino acid sequences was carried out using ClustalW 2.0. Taking in account TM predictions automatically carried out by softwares, sequence...”
- The human transporter associated with antigen processing: molecular models to describe peptide binding competent states.
Corradi, The Journal of biological chemistry 2012 - “...V. cholera, Escherichia coli and Salmonella typhimurium MsbA (UniProtKB access codes P21447 , Q9NRK6 , Q99T13 , Q9KQW9 , P60752 , and P63359 respectively), the sequence of rat TAP1 and TAP2 as well as the sequence of the heterodimeric ABC transporter TM0287/TM0288 from Thermotoga maritima were...”
- “...TAP2, Q03519 ; Rattus , TAP1, P36370 ; Rattus , TAP2, P36372 ; Sav1866 , Q99T13 (PDB access code 2HYD ); MsbA Vibrio cholerae (Msba_VibCh), Q9KQW9 (PDB access code 3B5X ); MsbA E. coli (MsbA_EColi), P60752 (PDB access code 3B5W ); MsbA S. typhimurium (MsbA SalTy),...”
- Recognition of sulfonylurea receptor (ABCC8/9) ligands by the multidrug resistance transporter P-glycoprotein (ABCB1): functional similarities based on common structural features between two multispecific ABC proteins
Bessadok, The Journal of biological chemistry 2011 - “...42 human and 2 bacterial, Sav1866 (accession number Q99T13) and MsbA (accession number A1A9J1), transmembrane ABC proteins were used for a phylogenetic...”
- Structural arrangement of the transmission interface in the antigen ABC transport complex TAP
Oancea, Proceedings of the National Academy of Sciences of the United States of America 2009 - “...MDL1 (ABCB1); P63359, S. typhimurium MsbA; and Q99T13, S. aureus Sav1866]. 1To whom the correspondence should be addressed. E-mail: tampe@em.uni-frankfurt.de....”
- “...P08183, human MDL1 (ABCB1); P63359, S. typhimurium MsbA; and Q99T13, S. aureus Sav1866] derived by using ClustalW2 is shown. Coupling helices 1 and 2, the...”
- Molecular model of the outward facing state of the human P-glycoprotein (ABCB1), and comparison to a model of the human MRP5 (ABCC5)
Ravna, Theoretical biology & medical modelling 2007 - “...accession number Q9BX80 ), human ABCC4 (SWISS-PROT accession number O15439 ), Sav1866 (SWISS-PROT accession number Q99T13 ), Vibrio cholerae MsbA (SWISS-PROT accession number Q9KQW9 ) and Escherichia coli MsbA (SWISS-PROT accession number P60752 ). The alignments were used as a basis, and adjusted in ICM for...”
- Comparative virulence studies and transcriptome analysis of Staphylococcus aureus strains isolated from animals
Iqbal, Scientific reports 2016 - “...protein were also among DEGs. Genes involved in drug resistance mechanisms including ermC , and SAAV_1916 were upregulated. In addition, genes essential for bacterial survival such cysK , trxA , prop , SAAV_0149, SAAV_0833, SAAV_1344, SAAV_1732, SAAV_2243 and SAAV_2452 were up-regulated in differential gene expression. Furthermore,...”
- “...in the MRSA1679a test strain. Verification by RT-qPCR Nine genes ( blaZ , ermC , SAAV_1916, sarA , sdrE , icaA , eno , thyA and ureF ) encoding proteins related to the resistance and virulence mechanism of S. aureus were selected for validation of RNA-seq...”
- The Petri dish under the ice: permafrost pathogens and their impact on global healthcare and antibiotic resistance
Saleem, Annals of medicine and surgery (2012) 2024 - “...baumannii, and Janibacter melonis, 394 Most prevalent: AGly, Bla, Flq, rpoB2, EF-Tu, novA, parY and sav1866, Multidrug Efflux type. Achromobacter species: acquired resistance to fluoroquinolones. S.epidermidis and S.capitis were resistant to methicillin. The Paenibacillus provencensis isolate: resistant to all tested beta lactams N/A N/A N/A N/A...”
- Evaluation of Antibiotic Resistance Mechanisms in Gram-Positive Bacteria
Rajput, Antibiotics (Basel, Switzerland) 2024 - A Comparative Phenotypic and Genomic Analysis of Methicillin-Resistant Staphylococcus aureus ST45 Isolates From Cellulitis and Osteomyelitis in Taiwan
Peng, The Journal of infectious diseases 2024 - “...including norA , norB , norC , lmrS , mdeA , sdrM , mepA , sav1866 , abcA , and sepA [ 30 ] were also analyzed. Among them, specific substitution (G470V) in MdeA was detected only in OM-MRSA strains ( Figure 2 and Supplementary Table...”
- Comparative genome analyses of Staphylococcus aureus from platelet concentrates reveal rearrangements involving loss of type VII secretion genes
Ighem, Access microbiology 2024 - “...( parC parE, gyrA, gyrB, norA, norB ), SMR ( sepA ), ABC efflux ( sav1866 ) and MATE (multidrug and toxic compound extrusion) efflux ( mepR, mepA ) were present in all strains. Likewise, genes conferring resistance to methicillin ( mecA ), fosfomycin ( glpT,...”
- Resistome, mobilome, and virulome explored in clinical isolates derived from acne patients in Egypt: unveiling unique traits of an emerging coagulase-negative Staphylococcus pathogen
Amer, Frontiers in cellular and infection microbiology 2024 - “...(3) 0.955 (86) sdrM , FosBx1 , mdeA , qacJ , lnuA , gyrB , sav1866 , vgaA 48AF mecA , blaZ , norA , fusB , norC , sepA , sdrM , vanT , dfrC , mdeA , qacJ , gyrB blaZ , fosB ,...”
- Effect of folA gene in human breast milk-derived Limosilactobacillus reuteri on its folate biosynthesis
Jiang, Frontiers in microbiology 2024 - “...analysis technology, the crystal structures of several ABC transport proteins have been successfully analyzed, including Sav1866 multidrug outward transport protein from Staphylococcus aureus , ModBCA MoO4/WO4 inward transport protein from Archaeoglobus fulgidus, and BtuCD vitamin B12 inward transport protein from Escherichia coli ( Hollenstein et al.,...”
- The Alternating Access Mechanism in Mammalian Multidrug Resistance Transporters and Their Bacterial Homologs
Badiee, Membranes 2023 - “...resistance proteins such as MRP1 and Pgp (MDR1), as well as bacterial counterparts such as Sav1866 and lipid flippase MsbA. By exploring the structural and functional features of these MDR proteins, we shed light on the roles of their nucleotide-binding domains (NBDs) and transmembrane domains (TMDs)...”
- “...the transport process. Notably, while the structures of NBDs in prokaryotic ABC proteins, such as Sav1866, MsbA, and mammalian Pgp, are identical, MRP1 exhibits distinct characteristics in its NBDs. Our review also emphasizes the importance of two ATP molecules for the formation of an interface between...”
- Virtual screening and antimicrobial evaluation for identification of natural compounds as the prospective inhibitors of antibacterial drug resistance targets in Staphylococcus aureus
Sharma, Fitoterapia 2023 (PubMed)- “...like -Lactamase, Penicillin Binding Protein 2a (PBP2a), Dihydrofolate reductase (DHFR), DNA gyrase, Multidrug ABC transporter SAV1866, Undecaprenyl diphosphate synthase (UPPS), etc. Thymol, eugenol, gallic acid, l-ascorbic acid, curcumin, berberine and quercetin were identified as potential molecules based on their docking score, binding interactions. These molecules were...”
- More
- Essential Fitness Repertoire of Staphylococcus aureus during Co-infection with Acinetobacter baumannii In Vivo
Li, mSystems 2022 - “...the transportation of diverse substrates. Note that 5 genes with unknown substrate specificity, including NWMN_1203, NWMN_1758, NWMN_0251, NWMN_0654, NWMN_2340, were not drawn in the diagram. Validation of candidate fitness factors required in type-specific infection. To verify the accuracy of the genome-scale Tn-seq analyses, 3 individual genes,...”
- Molecular co-localization of multiple drugs in a nanoscopic delivery vehicle for potential synergistic remediation of multi-drug resistant bacteria
Banerjee, Scientific reports 2022 - “...bacteria 75 Table 5 Effect of antituberculosis drug Rifampicin (RF) on MRSA. Compound Mode Activity SACOL1924 Direct Potential multi-drug exporting ABC transporter permease/ATP-binding protein 76 SACOL2252 Direct AcrB/AcrD/AcrF family protein and part of multidrug resistance pumps 77 Mdr- SACOL0700, SACOL2430, SACOL2431 Direct ABC transporter ATP-binding protein/permease...”
- Changes in the Staphylococcus aureus transcriptome during early adaptation to the lung
Chaffin, PloS one 2012 - “...systems were upregulated in vivo. The greatest increase was seen in toxin export gene msbA (SACOL1924, 7.3 fold) and the trans-membrane efflux pump gene, sbtA (4 and 10 fold higher in vivo after 30 compared to stationary phase or fresh LB samples). Also significantly higher were...”
- Staphylococcus aureus HrtA is an ATPase required for protection against heme toxicity and prevention of a transcriptional heme stress response
Stauff, Journal of bacteriology 2008 - “...NWMN_1503 SACOL0857 3.7 20.4 SACOL1168 SACOL1169 32.3 29.3 SACOL1924 2.4 SACOL2511 SACOL2584 4.8 23.7 SACOL0137 11.5 cap5B SACOL0138 11.2 cap5C SACOL0143 8.3...”
DVU0105 glutamine ABC transporter, ATP-binding protein from Desulfovibrio vulgaris Hildenborough
28% identity, 79% coverage
- High-throughput isolation and characterization of untagged membrane protein complexes: outer membrane complexes of Desulfovibrio vulgaris
Walian, Journal of proteome research 2012 - “...fadD, long-chain-fatty-acid--CoA ligase DVU0062 RND efflux system, outer membrane protein,NodT family DVU1455 conserved hypothetical protein DVU0105 glnQ, glutamine ABC transporter, ATP-binding protein DVU1537 lipoprotein, putative DVU0133 hypothetical protein DVU1582 hypothetical protein DVU0263 tmcA, Transmembrane complex, tetraheme cytochrome c3 DVU1648 lipoprotein, putative DVU0264 tmcB, Transmembrane complex, ferredoxin,...”
- Energetic consequences of nitrite stress in Desulfovibrio vulgaris Hildenborough, inferred from global transcriptional analysis
He, Applied and environmental microbiology 2006 - “...2017 by University of California, Berkeley DVU0095 DVU0105 DVU0106 DVU0107 DVU0388 DVU0624 DVU0625 DVU0751 DVU0752 DVU0966 DVU0967 DVU0968 DVU1026 DVU1237...”
- Global analysis of heat shock response in Desulfovibrio vulgaris Hildenborough
Chhabra, Journal of bacteriology 2006 - “..."Signature" genes from D. vulgarisa Description Log2R DVU0105 DVU0162 DVU0305 DVU0386 DVU0402 DVU0403 DVU0405 DVU0456 DVU0846 DVU0847 DVU0849 DVU0850 DVU1067...”
azo2266 probable glutamine transport ATP-binding protein from Azoarcus sp. BH72
29% identity, 89% coverage
SO_3665 ABC transporter, ATP-binding/permease protein, putative from Shewanella oneidensis MR-1
32% identity, 37% coverage
bgla_2g29570 ABC transporter ATP-binding protein from Burkholderia gladioli BSR3
31% identity, 41% coverage
WP_124781844 SAV1866 family putative multidrug efflux ABC transporter from Staphylococcus aureus
32% identity, 38% coverage
- Comparison of Antibiotic Resistance Mechanisms in Antibiotic-Producing and Pathogenic Bacteria
Ogawara, Molecules (Basel, Switzerland) 2019 - “...aminoglycoside-related transporters constituting of 16 members. The similarity values Es between SAV1866 in Staphylococcus aureus (WP_124781844) and one of those in sub-cluster C4 range from 4.6e-06 ( S. hygroscopicus Hyg28, ABC42565) to 4.5e-70 ( S. tenebrasius AprW, CAF33030). The other sub-clusters contain ABC permeases such as...”
- “...The cluster B are ABC transporter components with low similarity to SAV1866 in S. aureus (WP_124781844) ( Figure S5 ). The cluster D includes 9 MFS members. The nine members in the cluster D and 2 members in the cluster A ( M. olivasterospora ForV, CAF31538...”
EAMY_0863 putative ABC transport system, ATP-binding component from Erwinia amylovora CFBP1430
31% identity, 90% coverage
Q7RVS1 Multidrug resistance protein MDR from Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
NCU07546 multidrug resistance protein MDR from Neurospora crassa OR74A
29% identity, 17% coverage
- Do mitochondria use efflux pumps to protect their ribosomes from antibiotics?
Islam, Microbiology (Reading, England) 2023 - “...(accession no., e-value)* Arabidopsis thaliana (accession no., e-value)* Homo sapiens (accession no., e-value)* Reference NCU07546 Q7RVS1 ABC P97998, 4.1E^80 Q9SYI2, 3.2E^267 P08183, 4.0E^298 [ 79 ] MDR3 , NCU09975 V5IP78 ABC P97998, 8.0E^63 Q9FHF1, 3.9E^225 P08183, 8.4E^237 [ 79 ] ATM1, NCU05029 Q7RX59 ABC P97998, 5.2E^58...”
- Do mitochondria use efflux pumps to protect their ribosomes from antibiotics?
Islam, Microbiology (Reading, England) 2023 - “...protein kinase inhibitor [ 80 ]. Transcription of both MDR-3 and the ABC transporter gene NCU07546 is induced in the presence of (thio)xanthones, compounds with anti-cancer properties [ 81 ], suggesting that they could be involved in a response to toxins. Large-scale screens for drug sensitivity...”
- “...albicans (accession no., e-value)* Arabidopsis thaliana (accession no., e-value)* Homo sapiens (accession no., e-value)* Reference NCU07546 Q7RVS1 ABC P97998, 4.1E^80 Q9SYI2, 3.2E^267 P08183, 4.0E^298 [ 79 ] MDR3 , NCU09975 V5IP78 ABC P97998, 8.0E^63 Q9FHF1, 3.9E^225 P08183, 8.4E^237 [ 79 ] ATM1, NCU05029 Q7RX59 ABC P97998,...”
- The pH Signaling Transcription Factor PAC-3 Regulates Metabolic and Developmental Processes in Pathogenic Fungi
Martins, Frontiers in microbiology 2019 - “...for transporter proteins, specifically the ABC drug exporter AtrF (NCU08056), the multidrug resistance protein MDR (NCU07546), a major facilitator superfamily transporter (NCU06847), the MFS monocarboxylate transporter (NCU05089), and the MFS multidrug transporter (NCU06860). In high Pi conditions we observed significantly more induced genes than repressed, in...”
- Transcription profiling of the Neurospora crassa response to a group of synthetic (thio)xanthones and a natural acetophenone
Pedro, Genomics data 2015 - “...the tested (thio)xanthone derivatives), we also observed that NCU05591 (induced by TX129, TX34 and XP13), NCU07546 and NCU09975 (induced by TX34 and XP13) and NCU04161 (induced by XP13) were induced by more than one of the compounds ( Fig.3 B). Thus, our data indicate that NCU09830,...”
- “...while CDR4 is an important mediator of resistance to azole drugs [28] . NCU09975 and NCU07546 are ABC transporters that belong to the multidrug resistance (MDR) subfamily. NCU09975 encodes ABC-3, an ABC transporter that performs the efflux of staurosporine in N. crassa [29] , [30] ....”
- CZT-1 is a novel transcription factor controlling cell death and natural drug resistance in Neurospora crassa
Gonçalves, G3 (Bethesda, Md.) 2014 - “...these genes in czt-1 cells ( Figure 7A and File S5 ), including NCU02544, NCU03591, NCU07546, NCU08056/ atrf , NCU10009/ atrf-2 , NCU07276, and NCU09975/ abc3 . The latter gene plays a crucial role during the response of N. crassa to staurosporine since we observed that...”
- “...other ABC transporter genes are induced. These include NCU05591/ cdr4 ( Figure 7B , ii), NCU07546 ( Figure 7B , iii), and NCU08382 ( Figure 7B , iv). CDR4 was shown to be involved in resistance to azoles in Neurospora ( Zhang et al. 2012 )....”
- Isolation and Characterization of the Colletotrichum acutatum ABC Transporter CaABC1
Kim, The plant pathology journal 2014 - “...genes homologous to CaABC1 in other organisms have different roles. For example, a homologous gene NCU07546 in Neurospora crassa was up-regulated in the death-inducer staurosporine ( Fernandes et al., 2011 ), and C47A10.1 in Caenorhabditis elegans was induced in exposure to cadmium. In addition, future studies...”
- Global gene expression and focused knockout analysis reveals genes associated with fungal fruiting body development in Neurospora crassa
Wang, Eukaryotic cell 2014 - “...kex2 (NCU03219), ste13 (NCU02515), ram2 (NCU03632), ste6 (NCU07546), ste14 (NCU00034), ste24 (NCU03637), and axl1 (NCU00481), showed moderate correlation with...”
- Modulation of fungal sensitivity to staurosporine by targeting proteins identified by transcriptional profiling
Fernandes, Fungal genetics and biology : FG & B 2011 - “...when N. crassa cells are exposed to STS ( Fig. 1C ). The expression of NCU07546 , a paralog of NCU09975 ( Fig. S2A ) was used as control, and showed similar expression levels in the presence or absence of STS. Because specific mutants of respiratory...”
- “...(lower panel). (C) Quantification by RT-PCR of relative expression levels of the genes encoding ABC3, NCU07546 and NCU09141 performed in the wild type strain (wt) and the complex I mutants (nuo51 and nuo78) following 5-hour germination and 30 minutes incubation in the absence (black bars) or...”
TON_0243 ABC-type cobalt transport system, ATPase component from Thermococcus onnurineus NA1
29% identity, 85% coverage
HMPREF1014_04858 peptidase domain-containing ABC transporter from Bacillus sp. 7_6_55CFAA_CT2
30% identity, 29% coverage
- Novel LanT associated lantibiotic clusters identified by genome database mining
Singh, PloS one 2014 - “...5 Bacillus cereus ATCC 4342 ZP_04287173.1 bcere0010_52930 50 Unknown LanM 6 Bacillus sp. 7_6_55CFAA_CT2 ZP_09359395.1 HMPREF1014_04858 52 Unknown LanM 7 Bacillus licheniformis DSM 13= ATCC 14580 YP_081202.1 BL00929 50 Lichenicidin LanM 8 Geobacillus sp. G11MC16 ZP_03149641 G11MC16DRAFT_3400 47 G_sp_G11MC16 LanM 9. Geobacillus thermodenitrificans NG80-2 YP_001126158.1 GTNG_2061...”
- “...(HMPREF1014_04862) was also found next to the three hypothetical proteins, besides the bifunctional LanT homolog (HMPREF1014_04858). Bacillus mojavensis RO-H-1 Analysis of draft genome sequence of B. mojavensis revealed a lantibiotic biosynthetic cluster ( Fig. 6 ) comprising of two identical putative precursor peptides (BmojR_010100015733 and 38)...”
IRTA_MYCT3 / G7CBF5 Mycobactin import ATP-binding/permease protein IrtA; EC 7.2.2.- from Mycolicibacterium thermoresistibile (strain ATCC 19527 / DSM 44167 / CIP 105390 / JCM 6362 / NCTC 10409 / 316) (Mycobacterium thermoresistibile) (see paper)
30% identity, 24% coverage
- function: Part of the ABC transporter complex IrtAB involved in the import of iron-bound mycobactin (Fe-MBT) and carboxymycobactin (Fe- cMBT) (PubMed:32296173). Has a preference for Fe-MBT over Fe-cMBT (PubMed:32296173). Mycobactins are then reduced by the siderophore interaction domain to facilitate iron release in the bacterial cell (PubMed:32296173). Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation (PubMed:32296173).
cofactor: FAD
subunit: Forms a heterodimer with IrtB.
ECs0887 ATP-binding component of glutamine high-affinity transport system from Escherichia coli O157:H7 str. Sakai
29% identity, 90% coverage
SAK_RS04085 ATP-binding cassette domain-containing protein from Streptococcus agalactiae A909
30% identity, 79% coverage
- Nitric Oxide Production and Effects in Group B Streptococcus Chorioamnionitis
Keith, Pathogens (Basel, Switzerland) 2022 - “...LFC Mean LFC SAK_RS04090 W903_RS03770 inner membrane protein YBBM-related iron transporter (fetB) 3.19 4.23 3.71 SAK_RS04085 W903_RS03765 hypothetical protein 3.02 4.18 3.60 SAK_RS07535 W903_RS07235 membrane component of amino acid ABC transporter 3.22 3.47 3.34 SAK_RS07540 W903_RS07240 hypothetical protein 3.22 3.30 3.26 SAK_RS06865 W903_RS06570 5-nucleotidase-related 3.16 3.34...”
LJ1813 ABC transporter ATPase and permease components from Lactobacillus johnsonii NCC 533
30% identity, 37% coverage
- Heme and menaquinone induced electron transport in lactic acid bacteria
Brooijmans, Microbial cell factories 2009 - “...gasseri ATCC 33323 LGAS_1841 LGAS_1842 LGAS_1843 LGAS_1844 Lactobacillus johnsonii NCC 533 LJ1810 LJ1811 LJ1812 (2e-116) LJ1813 (5e-110) Lactobacillus plantarum WCFS1 lp_1125 lp_1126 lp_1128 lp_1129 Lactobacillus reuteri 100-23 e Lr_0600 e Lr_0599 e Lr_0598 (3e-140) e Lr_0597(3e-120) Lactobacillus reuteri F275 Lreu_0505 Lreu_0506 Lreu_0507 (1e-136) Lreu_0508 (6e-121) Lactobacillus...”
LOC100810510 ABC transporter B family member 25 from Glycine max
31% identity, 33% coverage
Amuc_0672 ABC transporter related from Akkermansia muciniphila ATCC BAA-835
29% identity, 80% coverage
- Omics-based analysis of <i>Akkermansia muciniphila</i> cultivation in food-grade media
Geerlings, Microbiome research reports 2024 - “...Amuc_0221 and Amuc_0037), as well as peptide, aliphatic sulfonate, nitrate/sulfonate/bicarbonate, cobalt and manganese ABC transporters (Amuc_0672, AMUC_1297, Amuc_0408, Amuc_1198, Amuc_1199, Amuc_0056, Amuc_1380 and Amuc_1186) with an increase > 5-fold. In addition, genes involved in oxygen stress response were found to be higher in soy medium including...”
SE1540 glutamate ABC transporter ATP-binding protein from Staphylococcus epidermidis ATCC 12228
31% identity, 89% coverage
lptB / Q7CPN9 LPS export ABC transporter ATP-binding protein (EC 7.5.2.5) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 9 papers)
28% identity, 80% coverage
SMc02357 PUTATIVE HIGH-AFFINITY BRANCHED-CHAIN AMINO ACID TRANSPORT ATP-BINDING ABC TRANSPORTER PROTEIN from Sinorhizobium meliloti 1021
31% identity, 89% coverage
- Legume NCRs and nodule-specific defensins of actinorhizal plants-Do they share a common origin?
Salgado, PloS one 2022 - “...SMc01242 (signal peptide DUF1775 domain containing protein), SMc01800 (cytochrome C oxidase assembly protein subunit 15), SMc02357 (high affinity ABC transporter for branched-chain amino acids, ATP-binding protein), SMc02255 ( qtxA/cydA , encoding Cytochrome d ubiquinol oxidase subunit I) and SMb21487 ( cyoA , encoding cytochrome o ubiquinol...”
- “...enhanced in response to treatment with DgDef1SPCTPP (p<0.005). It is interesting that the expression of SMc02357 and of SMc01800 was also enhanced tendentiously, though below the level for statistical significance (p = 0.11), as the uptake of branched chain amino acids is a bacteroid feature due...”
ECH_0085 ABC transporter, ATP-binding protein from Ehrlichia chaffeensis str. Arkansas
29% identity, 88% coverage
G1XU57 ABC transporter domain-containing protein from Arthrobotrys oligospora (strain ATCC 24927 / CBS 115.81 / DSM 1491)
29% identity, 22% coverage
DA471_RS01675 amino acid ABC transporter ATP-binding protein from Staphylococcus aureus
31% identity, 88% coverage
ZP_03149641 ABC transporter-related protein from Geobacillus sp. G11MC16
31% identity, 30% coverage
- Novel LanT associated lantibiotic clusters identified by genome database mining
Singh, PloS one 2014 - “...Bacillus licheniformis DSM 13= ATCC 14580 YP_081202.1 BL00929 50 Lichenicidin LanM 8 Geobacillus sp. G11MC16 ZP_03149641 G11MC16DRAFT_3400 47 G_sp_G11MC16 LanM 9. Geobacillus thermodenitrificans NG80-2 YP_001126158.1 GTNG_2061 47 Geobacillin LanM 10. Bacillus cereus Rock 13 ZP_04248716.1 bcere0017_56490 46 Unknown LanM 11. Bacillus mojavensis RO-H-1 ZP_10514325.1 BmojR_010100015748 46...”
TAGA_DICDI / Q9GTN7 Serine protease/ABC transporter B family protein tagA; EC 3.4.21.- from Dictyostelium discoideum (Social amoeba) (see 3 papers)
DDB_G0293002 ABC transporter B family protein from Dictyostelium discoideum AX4
28% identity, 12% coverage
- function: Required for a general cell fate determination at the onset of development. Required for the specification of an initial population of prespore cells in which tagA is expressed. Required for normal SDF-2 signaling during spore encapsulation.
disruption phenotype: TagA mutant aggregates elaborate multiple prestalk cell regions during development and produce spores asynchronously and with low viability. They produce about twice as many prestalk cells as the wild type as judged by a prestalk cell reporter construct. When mixed with wild-type cells, tagA-cells become overrepresented in the prestalk cell population, suggesting that this phenotype is cell-autonomous. - Comparative genome and transcriptome analyses of the social amoeba Acytostelium subglobosum that accomplishes multicellular development without germ-soma differentiation
Urushihara, BMC genomics 2015 - “...A. subglobosum lineage a Gene b Product Mutant information c Involved in cell fate-determination tagA (DDB_G0293002) ABC transporter B family protein, serine protease Multiple tips in mound (partial KO); Aberrant fruiting body morphology (KO) Involved in stalk-cell diversification rtaA* (DDB_G0271852) Lipid-translocating exporter family protein Expressed in...”
PSCT_04355 phosphate ABC transporter ATP-binding protein from Pseudomonas sp. SCT
28% identity, 80% coverage
- Genomic Analysis of Pseudomonas sp. Strain SCT, an Iodate-Reducing Bacterium Isolated from Marine Sediment, Reveals a Possible Use for Bioremediation
Harada, G3 (Bethesda, Md.) 2019 - “...are not SCT strain-specific, although the flanking genes yjlD -CDS -oprD-ubiG-pstS1-pstC-pstA-pstB (locus_tag range: PSCT_04348 to PSCT_04355) are SCT strain-specific. Bacterial uptake of phosphate occurs via Pi-specific transport (Pst) systems, which are multi-subunit ABC transporters encoded by a four-gene operon, pstSCAB ( Gebhard et al. 2009 )....”
- “...strain-specific. The SCT strain-specific pstSCAB operon (contig accession number: BDJA01000012; locus_tag: PSCT_04352, PSCT_04353, PSCT_04354, and PSCT_04355) is flanked by ubiG , which encodes ubiquinone biosynthesis O-methyltransferase also annotated as arsenite methyltransferase [EC:2.1.1.137] (KEGG: K07755). Another pstSCAB operon (contig accession number: BDJA01000001; locus_tag: PSCT_00287, PSCT_00288, PSCT_00289, and...”
YP_001126158 Lantibiotic mersacidin transporter system from Geobacillus thermodenitrificans NG80-2
GTNG_2061 peptidase domain-containing ABC transporter from Geobacillus thermodenitrificans NG80-2
31% identity, 30% coverage
- Lantibiotics from Geobacillus thermodenitrificans
Garg, Proceedings of the National Academy of Sciences of the United States of America 2012 - “...produced by Bacillus sp. HILY85/54728 (accession numbers YP_001126158 and YP_001126159). Both clusters have also been noted in bioinformatic genome mining...”
- Novel LanT associated lantibiotic clusters identified by genome database mining
Singh, PloS one 2014 - “...LanM 8 Geobacillus sp. G11MC16 ZP_03149641 G11MC16DRAFT_3400 47 G_sp_G11MC16 LanM 9. Geobacillus thermodenitrificans NG80-2 YP_001126158.1 GTNG_2061 47 Geobacillin LanM 10. Bacillus cereus Rock 13 ZP_04248716.1 bcere0017_56490 46 Unknown LanM 11. Bacillus mojavensis RO-H-1 ZP_10514325.1 BmojR_010100015748 46 Unknown LanM 12. Bacillus cereus VD166 ZP_17620816.1 IK9_05143 45 Unknown...”
HD0586 putative ABC transporter ATP-binding protein from Haemophilus ducreyi 35000HP
27% identity, 80% coverage
- Haemophilus ducreyi RpoE and CpxRA appear to play distinct yet complementary roles in regulation of envelope-related functions
Gangaiah, Journal of bacteriology 2014 - “...gcp fabZ galE rmlBc glmMc ftsH HD0552 HD0553 HD0586 Outer membrane protein assembly and insertion D15/bamA smpA/bamE lppc lolA Peptidoglycan metabolism murA...”
- “...lgtB, waaF, glmM, galE, ftsH, HD0552, HD0553, and HD0586), OMP assembly and insertion (D15/ bamA, smpA/bamE, lpp, and lolA), peptidoglycan metabolism 4022...”
W903_RS03765 ATP-binding cassette domain-containing protein from Streptococcus agalactiae CNCTC 10/84
30% identity, 79% coverage
- Nitric Oxide Production and Effects in Group B Streptococcus Chorioamnionitis
Keith, Pathogens (Basel, Switzerland) 2022 - “...Mean LFC SAK_RS04090 W903_RS03770 inner membrane protein YBBM-related iron transporter (fetB) 3.19 4.23 3.71 SAK_RS04085 W903_RS03765 hypothetical protein 3.02 4.18 3.60 SAK_RS07535 W903_RS07235 membrane component of amino acid ABC transporter 3.22 3.47 3.34 SAK_RS07540 W903_RS07240 hypothetical protein 3.22 3.30 3.26 SAK_RS06865 W903_RS06570 5-nucleotidase-related 3.16 3.34 3.25...”
A9497_03790 amino acid ABC transporter ATP-binding protein from Streptococcus thermophilus
32% identity, 79% coverage
- Technological and Genomic Analysis of Roles of the Cell-Envelope Protease PrtS in Yoghurt Starter Development
Tian, International journal of molecular sciences 2018 - “...AKL23_RS00860 AKL23_RS05335 ABC transporter substrate-binding protein A9497_01795 A9497_01800 A9497_09175 AKL23_RS05340 AKL23_RS05345 AKL23_RS03035 ABC transporter permease A9497_03790 A9497_09180 AKL23_RS03040 AKL23_RS07400 ABC transporter ATP-binding protein Methionine A9497_07635 AKL23_RS01505 ABC transporter ATP-binding protein A9497_07640 AKL23_RS01510 ABC transporter permease Polar amino acid A9497_03800 AKL23_RS07410 ABC transporter permease Serine/threonine A9497_07645 AKL23_RS01515...”
Bbr_0166 dipeptide/oligopeptide/nickel ABC transporter permease/ATP-binding protein from Bifidobacterium breve UCC2003
28% identity, 34% coverage
AAA66477.1 SMDR2 from Schistosoma mansoni (see paper)
31% identity, 17% coverage
XF1409 ABC transporter ATP-binding protein from Xylella fastidiosa 9a5c
29% identity, 75% coverage
TC 3.A.1.3.25 / Q9CES4 Glutamine ABC transporter ATP-binding protein, component of Glutamine transporter, GlnQP. Takes up glutamine, asparagine and glutamate which compete for each other for binding both substrate and the transmembrane protein constituent of the system (Fulyani et al. 2015). Tandem substrate binding domains (SBDs) differ in substrate specificity and affinity, allowing cells to efficiently accumulate different amino acids via a single ABC transporter. Analysis revealed the roles of individual residues in determining the substrate affinity from Lactococcus lactis subsp. lactis (strain IL1403)
30% identity, 78% coverage
- substrates: Asparagine, Glutamine, glutamate
BOV_A0500 ABC transporter ATP-binding protein from Brucella ovis ATCC 25840
29% identity, 66% coverage
- Identification of Brucella ovis exclusive genes in field isolates from Argentina
Alvarez, Veterinary journal (London, England : 1997) 2016 (PubMed)- “...10.1016/j.tvjl.2015.12.005 Elsevier Ltd Fig. 1 Presence of the BOV_A0500 (a) and BOV_0198 (b) genes in Brucella spp. Agarose gel showing the PCR...”
- The predicted ABC transporter AbcEDCBA is required for type IV secretion system expression and lysosomal evasion by Brucella ovis
Silva, PloS one 2014 - “...sequence to sequences available at the NCBI protein database (BLASTx). Two proteins encoded by abcA (BOV_A0500) and abcB (BOV_A0501), which were deleted in the abcBA mutant strain, are predicted to be ATPases of ABC systems, with conserved Walker A and B motifs. Therefore, deletion of abcA...”
- ATP-Binding Cassette Systems of Brucella
Jenner, Comparative and functional genomics 2009 - “...Dipeptide import IM BMEII0286 BruAb20951 BRA1008 BOV_A0502 BCAN_B1030 OPN Dipeptide import ABC BMEII0287 BruAb20948 BRA1011 BOV_A0500 BCAN_B1029 OPN Dipeptide import ABC BMEII0288 BruAb20949 BRA1010 BOV_A0501 BCAN_B1028 70 OPN Nickel import BP BMEII0487 BruAb20428 BRA0804 BOV_A0754 BCAN_B0818, NikA OPN Nickel import IM BMEII0488, nikB BruAb20429, nikB BRA0802,...”
VVMO6_04162 ABC transporter ATP-binding protein from Vibrio vulnificus MO6-24/O
31% identity, 39% coverage
- MARTX Toxin-Stimulated Interplay between Human Cells and Vibrio vulnificus
Kim, mSphere 2020 - “...manganese transporter 11 TMS (VVMO6_01834), superoxide dismutase (VVMO6_00202), and microcin C ABC transporter ATP-binding protein (VVMO6_04162). Notably, a number of pilus-related genes, namely, the MshA pilin gene (VVMO6_03886) and the Tad1 pilin biogenesis locus genes (VVMO6_01213, VVMO6_01204, VVMO6_01205, and VVMO6_01211), were significantly (at least 2.4-fold) more...”
GlnQ / b0809 L-glutamine ABC transporter ATP binding subunit (EC 7.4.2.1) from Escherichia coli K-12 substr. MG1655 (see 2 papers)
GlnQ / P10346 L-glutamine ABC transporter ATP binding subunit (EC 7.4.2.1) from Escherichia coli (strain K12) (see paper)
GLNQ_ECOLI / P10346 Glutamine transport ATP-binding protein GlnQ from Escherichia coli (strain K12) (see paper)
TC 3.A.1.3.2 / P10346 GlnQ aka B0809, component of Three component ABC L-glutamine porter. The basal ATPase activity (ATP hydrolysis in the absence of substrate) is mainly caused by the docking of the closed-unliganded state of GlnH onto the transporter domain of GlnPQ. Unlike glutamine, arginine binds both GlnH domains, but does not trigger their closing. Comparison of the ATPase activity in nanodiscs with glutamine transport in proteoliposomes suggested that the stoichiometry of ATP per substrate is close to two from Escherichia coli (see 5 papers)
glnQ / GB|ABB65374.1 glutamine ABC transporter, ATP-binding protein GlnQ from Escherichia coli K12 (see 5 papers)
b0809 glutamine ABC transporter ATP-binding protein from Escherichia coli str. K-12 substr. MG1655
NP_415330 L-glutamine ABC transporter ATP binding subunit from Escherichia coli str. K-12 substr. MG1655
30% identity, 79% coverage
- function: Part of the binding-protein-dependent transport system for glutamine. Probably responsible for energy coupling to the transport system
subunit: Heterotetramer with 2 subunits of GlnQ and 2 subunits of GlnP. - substrates: Glutamine
- Metabolic shift of Escherichia coli under salt stress in the presence of glycine betaine
Metris, Applied and environmental microbiology 2014 - “...Putative selenate reductase b1241 b1241 b4260 b3556 b2414 b0031 b2095 b2095 b0809 b3213 b2579 b1237 b1237 b3671 2 5 2 2 4.5 4.5 2 4.5 2 4.5 2 2 2 4.5 4.5...”
- Physiological studies of Escherichia coli strain MG1655: growth defects and apparent cross-regulation of gene expression
Soupene, Journal of bacteriology 2003 - “...all strains include glnK-amtB (b0450 to b0451), glnHPQ (b0809 to b0811), potFGHI (b0854 to b0857), ycdGHIJKLM (b1006 to b1012), ydcSTUVW (b1440 to b1444),...”
- Ligand-free open-closed transitions of periplasmic binding proteins: the case of glutamine-binding protein.
Bermejo, Biochemistry 2010 - GeneRIF: Similar to other peripheral periplasmic binding proteins, a significant open-closed conformational change is observed upon ligand binding of glutamine-binding protein.
- The Role of Propionate-Induced Rearrangement of Membrane Proteins in the Formation of the Virulent Phenotype of Crohn's Disease-Associated Adherent-Invasive Escherichia coli
Pobeguts, International journal of molecular sciences 2024 - “...0.52 P02930 Outer membrane protein TolC 2.84 0.37 P69797 Mannose transprter ManX 153 2.31 0.30 P10346 glutamine ABC transporter ATP-binding protein GlnQ 91 3.05 0.40 Biosynthesis and binding of the siderophore enterobactin P0ADI4 Enterochelin synthase component B EntB 179 4.45 0.58 P10378 Enterochelin synthase component E...”
- “...Outer membrane protein Fadl 80 3.14 0.47 P02930 Outer membrane protein TolC 55 2.82 0.33 P10346 glutamine ABC transporter ATP-binding protein GlnQ 91 2.17 0.17 Biosynthesis and binding of the siderophore enterobactin P0ADI4 Enterochelin synthase component B EntB 124 6.89 0.55 P10378 Enterochelin synthase component E...”
- Biodistribution of 89Zr-DFO-labeled avian pathogenic Escherichia coli outer membrane vesicles by PET imaging in chickens
Li, Poultry science 2023 - “...Cell inner membrane 390 P0AA53 QMCA Posttranslational modification, protein turnover, chaperones Cell inner membrane 391 P10346 GLNQ Amino acid transport and metabolism Cell inner membrane 392 P0AC23 FOCA Inorganic ion transport and metabolism Cell inner membrane 393 P27434 RODZ Function unknown Cell inner membrane 394 P0ACB4...”
- The Escherichia coli proteome: past, present, and future prospects
Han, Microbiology and molecular biology reviews : MMBR 2006 - “...2--Continued Protein nameb Accession no.b P0AC55 GlnQ P10346 GlnS pI/MW Theoreticalc Experimentald Nitrogen regulatory protein P-II 2 Glutamine transport...”
- Proteome of Salmonella typhimurium SL1344: identification of novel abundant cell envelope proteins and assignment to a two-dimensional reference map
Qi, Journal of bacteriology 1996 - “...5.78 26,657 40 (MIEFKNVXKHFG) 6.37 26,540 GlnQ protein (P10346) 6.08 26,731 41 (XEL[P/G]VVXT) 42 (XEKKYIVALDQGTTS) 5.77 5.47 48,030 52,070 No matches Glycerol...”
- Glucitol induction in Bacillus subtilis is mediated by a regulatory factor, GutR
Ye, Journal of bacteriology 1994 - “...229 164 96 60 83 X Rb gut P03002 P23914 P10346 P00568 P01112 P02990 hhhhD A FIG. 3. Comparison of the putative helix-turn-helix (A) and nucleotide binding (B)...”
jhp0653 putative abc transporter, ATP-binding protein from Helicobacter pylori J99
28% identity, 90% coverage
GBAA_1933 ABC transporter ATP-binding protein from Bacillus anthracis str. 'Ames Ancestor'
27% identity, 92% coverage
- BrnQ-Type Branched-Chain Amino Acid Transporters Influence Bacillus anthracis Growth and Virulence
Dutta, mBio 2022 - “...facilitator superfamily (MFS) ( 18 , 48 ). The genome also contains five genes, GBAA_1931, GBAA_1933, GBAA_1934, GBAA_1935, and GBAA_1936, predicted to be ABC transporters for BCAAs as well as another gene, GBAA_0818, that is similar to bcaP , an amino acid permease gene that is...”
- “...BrnQ1 or other uncharacterized non-BrnQ-type transporters. The B. anthracis genome sequence indicates a locus, GBAA_1931, GBAA_1933, GBAA_1934, GBAA_1935, and GBAA_1936, predicted to encode a BCAA-associated ABC transporter. Major leucine transporters have not been identified in other Bacillus species. However, a putative BCAA permease of B. subtilis...”
JHW33_RS01275 glutamine ABC transporter ATP-binding protein GlnQ from Rahnella aceris
28% identity, 89% coverage
RL3547 putative ATP-binding component of ABC transporter protein from Rhizobium leguminosarum bv. viciae 3841
30% identity, 70% coverage
BCAL3101 ABC transporter ATP-binding protein from Burkholderia cenocepacia J2315
29% identity, 80% coverage
NP_001265699 ATP-dependent translocase ABCB1 from Cavia porcellus
31% identity, 18% coverage
CT653 ABC Transporter ATPase from Chlamydia trachomatis D/UW-3/CX
27% identity, 95% coverage
- Predicting phenotype and emerging strains among Chlamydia trachomatis infections
Dean, Emerging infectious diseases 2009 - “...mdhC CT376 FmdhC GGAGATGTTTTTGGCCTTGATTGT 519 RmdhC CGATTACTGCACTACCACGACTCT pdhA CT245 FpdhA CTACAGAAGCCCGAGTTTTT 549 RpdhA CTGTTTGTTGCATGTGGTGATAAG yhbG CT653 FyhbG TCAAGTCAATGCAGGAGAAAT 504 RyhbG GATAGTGTTGACGTACCATAGGAT pykF CT332 FpykF ATCTTATCGCTGCTTCGTT 525 RpykF cagcaataatagggagata lysS CT781 FlysS GAAGGAATCGATAGAACGCATAAT 576 RlysS ATACGCCGCATAACAGGGAAAAAC leuS CT209 FleuS TCCCTTGGTCGATCTCCTCAC 519 RleuS GGGCATCGCAAAAACGTAAATAGT Allelic profiles and concatenated...”
PGP1_CAEEL / P34712 Multidrug resistance protein pgp-1; P-glycoprotein A; P-glycoprotein-related protein 1; EC 7.6.2.2 from Caenorhabditis elegans (see paper)
P34712 ABC-type xenobiotic transporter (EC 7.6.2.2) from Caenorhabditis elegans (see paper)
TC 3.A.1.201.14 / P34712 P-glycoprotein-1 MDR exporter from Caenorhabditis elegans
30% identity, 16% coverage
- function: Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells
catalytic activity: ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2. - substrates: Ivermectin, drugs, xenobiotics
tcdb comment: Transports multiple drugs, cancer chemotherapy agents, cancer unrelated compounds and many xenobiotics including ivermectin (Ardelli 2013). The crystal structure at 3.4 A resolution is available (Jin et al. 2012). It has 4,000x higher affinity for actinomycin D in the membrane bilayers than in detergent. A "ball and socket joint" and salt bridges similar to ABC importers suggested that both types of systems, importers and exporters, use the same mechanism to interconnect ATP hydrolysis with transport and achieve alternating access of the substrate binding site to the two sides of the membrane - αCharges: partial atomic charges for AlphaFold structures in high quality
Schindler, Nucleic acids research 2023 - “...domain ( 24 ). We used a P-glycoprotein structure model from Caenorhabditis elegans (UniProt ID P34712). Visualising the charges (Figure 2 ) computed by Charges demonstrates the differences in charge distribution between the transmembrane parts and extracellular/intracellular ones. Figure 2. Structure of P-glycoprotein from Caenorhabditis elegans...”
- PGP-14 establishes a polar lipid permeability barrier within the C. elegans pharyngeal cuticle
Kamal, PLoS genetics 2023 - “...interaction with bile salt [ 79 ]. The Uniprot entries used are as follows: PGP-1 (P34712), PGP-2 (G5EDF9), PGP-3 (P34713), PGP-4 (Q20331), PGP-5 (Q17645), PGP-6 (Q22656), PGP-7 (Q22655), PGP-8 (G5EG03), PGP-9 (G5EG58), PGP-10 (Q18824), PGP-11 (Q19015), PGP-12 (Q19733), PGP-13 (Q19734), PGP-14 (G5EG61), ABCB1(aka MDR1)(P08183), ABCB4(aka MDR3)(P21439),...”
- RNA-Sequencing of Heterorhabditis nematodes to identify factors involved in symbiosis with Photorhabdus bacteria.
Bhat, BMC genomics 2022 - “...28. SMAD3 (P84022) 68. GLO-3 (Q24JJ8) Transcription factors Transmembrane transporters 29. daf-16 (O16850) 69. pgp-1 (P34712) 30. elt-2 (Q10655) 70. pgp-3 (P34713) 31. pnr (P52168) 71. SLC17A5 (Q9NRA2) 32. fos-1 (G5ECG2) 72. aqp-10 (Q09369) 33. TFEB (P19484) 73. AQP3 (Q08DE6) 34. PAX5 (Q02548) Mucosa associated protein...”
- Prediction of drug-ABC-transporter interaction--Recent advances and future challenges.
Montanari, Advanced drug delivery reviews 2015 - “...a State 2012 Jin et al . [ 64 ] 4F4C C. elegans Pgp-1 (Uniprot: P34712 ) 3.4 Open-in 2012 Shintre et al . [ 62 ] 3ZDQ , 4AYT , 4AYX , 4AYW H. sapiens ABC transporter 10 protein (Uniprot: Q9NRK6 ) 2.85 Open-in 2009...”
ABCB1 / P08183 ATP-dependent translocase ABCB1 (EC 7.6.2.2) from Homo sapiens (see 39 papers)
MDR1_HUMAN / P08183 ATP-dependent translocase ABCB1; ATP-binding cassette sub-family B member 1; Multidrug resistance protein 1; P-glycoprotein 1; Phospholipid transporter ABCB1; CD243 antigen; EC 7.6.2.2; EC 7.6.2.1 from Homo sapiens (Human) (see 8 papers)
P08183 ABC-type xenobiotic transporter (EC 7.6.2.2); ABC-type glutathione-S-conjugate transporter (EC 7.6.2.3) from Homo sapiens (see 10 papers)
TC 3.A.1.201.1 / P08183 Broad specificity multidrug resistance (MDR1; MDR-1; Pgp; P-gp; ABCB1; P-glycoprotein) efflux pump. It exports organic cations and amphiphilic compounds of unrelated chemical structure from Homo sapiens (Human) (see 19 papers)
NP_000918 ATP-dependent translocase ABCB1 isoform 2 from Homo sapiens
33% identity, 18% coverage
- function: Translocates drugs and phospholipids across the membrane (PubMed:2897240, PubMed:35970996, PubMed:8898203, PubMed:9038218). Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D- glucosylceramides and sphingomyelins (PubMed:8898203). Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug- resistant cells (PubMed:2897240, PubMed:35970996, PubMed:9038218).
catalytic activity: ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2.
catalytic activity: ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.
catalytic activity: a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ADP + phosphate + H(+) (RHEA:36439)
catalytic activity: a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ADP + phosphate + H(+) (RHEA:38583)
catalytic activity: a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ATP + H2O = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ADP + phosphate + H(+) (RHEA:38943)
catalytic activity: a sphingomyelin(in) + ATP + H2O = a sphingomyelin(out) + ADP + phosphate + H(+) (RHEA:38903)
subunit: Interacts with PSMB5. Finds in a complex with ABCB1, TFPI2 and PPP2R3C; leading to the dephosphorylation of ABCB1. - substrates: Berberine, anphiphilic compouds, anti-viral agents, antibiotics, calcein M, cancer chemotheraputic agents, depressants, detergents, emetics, histamines, hypertensive drugs, immunosuppressants, long-chain fatty acids, lopinavir, organic cations, peptides, phospholipids, protease inhibitors, sterols, synthetic tetramethylrosamine analogues
tcdb comment: These include: antibiotics, anti-viral agents, cancer chemotheraputic agents, hypertensives, depressants, histamines, emetics, and the protease inhibitor, lopinavir. Pgp also exports immunosuppressants, detergents, long-chain fatty acids, HIV protease inhibitors, synthetic tetramethylrosamine analogues, calcein M, etc.); it is also a peptide efflux pump, and peptide inhibitors have been designed (Tarasova et al. 2005). It is also a phospholipid (e.g., phosphatidyl serine), cholesterol and sterol flippase. It binds and probably transports inhibitors and agonists of SUR (3.A.1.208.4) (Bessadok et al., 2011). The 3-d structure has been determined (Aller et al., 2009). It can pump from the cytoplasmic leaflet to either the outer leaflet or the outer medium (Katzir et al., 2010). The inhibitor,5''-fluorosulfonylbenzoyl 5''-adenosine, an ATP analogue, interacts with both drug-substrate- and nucleotide-binding sites (Ohnuma et al., 2011). Inhibited by sildenafil (Shi et al., 2011), verapamil, indomethacin, probenecid, cetirizine (He et al. 2010), and lapatinib derivatives (Sodani et al., 2012), several of which are also substrates.HG-829 is a potent non-competitive inhibitor (Caceres et al., 2012). Berberine, palmatine, jateorhizine, cetirizine and coptisine are all P-gp substrates, and cyclosporin A and verapamil are potent inhibitors (He et al. 2010; Zhang et al., 2011). Transports clarithromycin (CAM), a macrolide antibiotic used to treat lung infections, more effectively than azithromycin (AZM) or telithromycin (TEL) (Togami et al. 2012). Nucleotides, lipids and drugs bind synergistically to the pump (Marcoux et al. 2013). Fluorescent substrates have been identified (Strouse et al. 2013). The central cavity undergoes alternating access during ATP hydrolysis (van Wonderen et al. 2014). Structural data suggest that signals are transduced through intracellular loops of the TMSs that slot into grooves on the NBDs. The Q loops at the base of these grooves are required to couple drug binding to the ATP catalytic cycle of drug export (Zolnerciks et al. 2014). Ocotillol analogues are strong competitive inhibitors (Zhang et al. 2015). Durmus et al. 2015 have reviewed PGP transport of cancer chemotheraputic agents. ABCB1 variants modulate therapeutic responses to modafinil and may partly explain pharmacoresistance in Narcolepse type 1 (NT1) patients (Moresco et al. 2016). Many inhibitors have been identified (Hemmer et al. 2015). The open-and-close motion of the protein alters the surface topology of P-gp within the drug-binding pocket, explaining its polyspecificity (Esser et al. 2016). The ATP- and substrate-coupled conformational cycle of the mouse Pgp transporter have been defined, showing that the energy released by ATP hydrolysis is harnessed in the NBDs in a two-stroke cycle (Verhalen et al. 2017). Rilpivirine inhibits MDR1- and BCRP-mediated efflux of abacavir and increases its transmembrane transport (Reznicek et al. 2017). It transports Huerzine A in the brain, a drug that is used for the treatment of Alzheimer's disease (Li et al. 2017). AbcB1 acts in concert with ABCA1, ABCG2 and ABCG4 to efflux amyloid-β peptide (Aβ) from the brain across the blood-brain barrier (BBB) (Kuai et al. 2018).The structure has been determined withthe ABCB1 inhibitor, zosuquidar, bound. This structure reveals the transporter in an occluded conformation with a central, enclosed, inhibitor-binding pocket lined by residues from all TMSs. The pocket spans almost the entire width of the lipid membrane and is occupied exclusively by two closely interacting zosuquidar molecules (Alam et al. 2018). Iit is also inhibited by dacomitinib (Fan et al. 2018). Moreover, Kim and Chen 2018 presented the structure of human P-glycoprotein in the outward-facing conformation, determined by cryo-electron microscopy at 3.4-Å resolution. The two nucleotide-binding domains form a closed dimer occluding two ATP molecules. The drug-binding cavity observed in the inward-facing structures is reorientated toward the extracellular space and is compressed to preclude substrate binding. This observation indicates that ATP binding, not hydrolysis, promotes substrate release (Kim and Chen 2018). P-gp also transports opioid peptides (Ganapathy and Miyauchi 2005). MDR1 has been quantified in primary human renal cell carcinoma cells and corresponding normal tissue, and down-regulation or expression loss was documented in tumor tissues, corroborating its importance in drug resistance and efficacy (Poetz et al. 2018). Regarding the conformational transitions, first the transition is driven by the NBDs, then transmitted to the cytoplasmic parts of TMSs, and finally to the periplasmic parts. The trajectories show that besides the translational motions, the NBDs undergo a rotation movement (Zhang et al. 2018). Isoxanthohumol is a substrate and competitive inhibitor which reverses ABCB1-mediated doxorubicin resistance (Liu et al. 2017). Tariquidar is a potent inhibitor, even when taken orally (Matzneller et al. 2018). Combined oral administration of the ovarian hormones, ethinyl estradiol and progesterone, significantly lowered both MDR-1 mRNA and MDR-1 protein in the ovary (Brayboy et al. 2018). Its expression in immune cells plays a protective role from xenobiotics and toxins (Bossennec et al. 2018). Oxypeucedanin reverses P-gp-mediated drug transport by inhibition of P-gp activity and P-gp protein expression as well as downregulation of P-gp mRNA levels (Dong et al. 2018). Alam et al. 2019determined the 3.5-Å cryo-EM structure of substrate-bound human ABCB1 reconstituted in lipidic nanodiscs, revealing a single molecule of the chemotherapeutic compound paclitaxel (Taxol) bound in a central, occluded pocket. A second structure of inhibited, human-mouse chimeric ABCB1 revealed two molecules of zosuquidar occupying the same drug-binding pocket. Minor structural differences between substrate- and inhibitor-bound ABCB1 sites are amplified toward the nucleotide-binding domains (NBDs), revealing how the plasticity of the drug-binding site controls the dynamics of the ATP-hydrolyzing NBDs. Ordered cholesterol and phospholipid molecules suggest how the membrane modulates the conformational changes associated with drug binding and transport (Alam et al. 2019). The TMS4/6 cleft may be an energetically favorable entrance gate for ligand entry into the binding pocket of P-gp (Xing et al. 2019). The epigallocatechin gallate derivative Y6 reverses drug resistance mediated by ABCB1 (Wen et al. 2019). Substrate-induced acceleration of ATP hydrolysis correlates with stabilization of a high-energy, post-ATP hydrolysis state characterized by structurally asymmetric nucleotide-binding sites, but this state is destabilized in the substrate-free cycle and by high-affinity inhibitors in favor of structurally symmetric nucleotide binding sites (Dastvan et al. 2019). It transports temozolomide (TMZ) which is used as a treatment of glioblasomas (Malmström et al. 2019). Unconventional cholesterol translocation on the surface of Pgp provides a secondary transport model for the known flippase activity of ABC exporters of cholesterol (Thangapandian et al. 2020). An in silico multiclass classification model capable of predicting the probability of a compound to interact with P-gp has been developed using a counter-propagation artificial neural network (CP ANN) based on a set of 2D molecular descriptors, as well as an extensive dataset of 2512 compounds (1178 P-gp inhibitors, 477 P-gp substrates and 857 P-gp non-active compounds) (Mora Lagares et al. 2019). Jervine is a natural teratogenic compound isolated from Veratrum californicum.Liu et al. 2019 showed that jervine sensitizes the anti-proliferation effect of doxorubicin (DOX) and that the synergistic mechanism was related to the intracellular accumulation of DOX via modulating ABCB1 transport. Jervine did not affect the expression of ABCB1 in mRNA or protein levels. However, jervine increased the ATPase activity of ABCB1 and probably served as a substrate of ABCB1. Jervine binds to a closed ABCB1 conformation and blocks drug entrance to the central binding site at the transmembrane domain (Liu et al. 2019). 6-Triazolyl-substituted sulfocoumarins inhibit P-gp (Podolski-Renić et al. 2019). ATP binding causes the conformational change to the outward-facing state, and ATP hydrolysis and subsequent release of γ-phosphate from both NBDs allow the outward-facing state to return to the original inward-facing state (Futamata et al. 2020). Replacing the eleven native tryptophans by directed evolution produces an active P-glycoprotein with site-specific, non-conservative substitutions (Swartz et al. 2020). ABCB1 polymorphisms alter P-gp-mediated drug (sunitinib) sensitivities - Association of variants in the ABCB1, CYP2C19 and CYP2C9 genes for Juvenile Myoclonic Epilepsy.
Jara-Prado, Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2024 (PubMed)- GeneRIF: Association of variants in the ABCB1, CYP2C19 and CYP2C9 genes for Juvenile Myoclonic Epilepsy.
- Intestinal P-gp activity is reduced in postmenopausal women under breast cancer therapy.
Ximenez, Clinical and translational science 2024 - GeneRIF: Intestinal P-gp activity is reduced in postmenopausal women under breast cancer therapy.
- The association of ABCB1 gene polymorphism with clinical response to carbamazepine monotherapy in patients with epilepsy.
Rashid, Molecular biology reports 2024 (PubMed)- GeneRIF: The association of ABCB1 gene polymorphism with clinical response to carbamazepine monotherapy in patients with epilepsy.
- Exploring the dynamics of the ABCB1 membrane transporter P-glycoprotein in the presence of ATP and active/non-active compounds through molecular dynamics simulations.
Mora, Toxicology 2024 (PubMed)- GeneRIF: Exploring the dynamics of the ABCB1 membrane transporter P-glycoprotein in the presence of ATP and active/non-active compounds through molecular dynamics simulations.
- The Effect of Platelet Activity, ABCB1 Genetic Polymorphism, and Renal Function on the Development of Ticagrelor-Related Dyspnea in Patients with Acute Coronary Syndrome.
Tamakauskas, Drug design, development and therapy 2024 - GeneRIF: The Effect of Platelet Activity, ABCB1 Genetic Polymorphism, and Renal Function on the Development of Ticagrelor-Related Dyspnea in Patients with Acute Coronary Syndrome.
- Population pharmacokinetics of lenalidomide in Chinese patients with influence of genetic polymorphisms of ABCB1.
Liang, Scientific reports 2024 - GeneRIF: Population pharmacokinetics of lenalidomide in Chinese patients with influence of genetic polymorphisms of ABCB1.
- NAT10-mediated mRNA N4-acetylcytidine modification of MDR1 and BCRP promotes breast cancer progression.
Zhao, Thoracic cancer 2024 - GeneRIF: NAT10-mediated mRNA N4-acetylcytidine modification of MDR1 and BCRP promotes breast cancer progression.
- Influence of GPRC5A-Regulated ABCB1 Expression on Lung Adenocarcinoma Proliferation.
Li, Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih 2024 (PubMed)- GeneRIF: Influence of GPRC5A-Regulated ABCB1 Expression on Lung Adenocarcinoma Proliferation.
- More
- Integrating Network Pharmacology, Molecular Docking and Experimental Validation to Explore the Pharmacological Mechanisms of Quercetin Against Diabetic Wound
Zhang, International journal of medical sciences 2024 - “...repairing. No. Gene Uniprot ID No. Gene Uniprot ID No. Gene Uniprot ID 1 ABCB1 P08183 31 DPP4 P27487 61 MYLK Q15746 2 ABCC1 P33527 32 DRD4 P21917 62 NCOA1 Q15788 3 ABCG2 Q9UNQ0 33 EGFR P00533 63 NOS3 P29474 4 ACHE P22303 34 ESR1 P03372...”
- Naringin and temozolomide combination suppressed the growth of glioblastoma cells by promoting cell apoptosis: network pharmacology, in-vitro assays and metabolomics based study
Bisht, Frontiers in pharmacology 2024 - “...polymerase-1 (PARP1) P17706 T-cell protein-tyrosine phosphatase (PTPN2) P09382 Galectin-1 (LGALS1) P00918 Carbonic anhydrase II (CA2) P08183 P-glycoprotein 1 (by homology) (ABCB1) P03372 Estrogen receptor alpha (ESR1) Q92731 Estrogen receptor beta (ESR2) O14746 Telomerase reverse transcriptase (TERT) P15121 Aldose reductase (AKR1B1) Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 (TDP1) P25101...”
- Evodiamine inhibits proliferation and induces apoptosis of nasopharyngeal carcinoma cells via the SRC/ERBB2-mediated MAPK/ERK signaling pathway.
Liu, Journal of translational medicine 2024 - “...amyloid A4 protein APP P05067 16 Cyclin-dependent kinase 4 CDK4 P11802 17 P-glycoprotein 1 ABCB1 P08183 18 Rho-associated protein kinase 1 ROCK1 Q13464 19 Matrix metalloproteinase 1 MMP1 P03956 20 Carnitine O-palmitoyltransferase 1, liver isoform CPT1A P50416 21 Cytochrome P450 19A1 CYP19A1 P11511 22 Interleukin-8 CXCL8...”
- Genetic Signatures for Distinguishing Chemo-Sensitive from Chemo-Resistant Responders in Prostate Cancer Patients.
Gumenku, Current issues in molecular biology 2024 - “...on 19 November 2023) [ 21 ]. For ABCB1, amino acid sequences of the protein (P08183) were sourced from the Universal Protein Resource (UniProt) ( https://www.uniprot.org/ accessed on 15 November 2023) and modeled using the Swiss Model online tools ( https://swissmodel.expasy.org/ accessed on 15 November 2023)....”
- Proteomic Dynamics of Multidrug Resistance Mechanisms in Lucena 1 Cell Line.
Beraldo-Neto, Cells 2024 - “...such as drug resistance. The main finding of these data is the protein Translocase ABCB1 (P08183), which is an ATP-dependent efflux pump responsible for eliminating substances, including chemotherapeutic drugs, in multiresistant cells [ 18 , 19 ]. In order to understand the distinctive metabolic dynamics of...”
- “...147.82 19 1 Actin, gamma-enteric smooth muscle P62736 147.82 19 1 Actin, aortic smooth muscle P08183 147.56 29 23 ATP-dependent translocase ABCB1 Q8N257 130.83 18 1 Histone H2B type 3-B Q02952 126.10 13 13 A-kinase anchor protein 12 P09960 125.99 19 18 Leukotriene A-4 hydrolase Q6FI13...”
- Computational Analysis of Lenalidomide and Pomalidomide Enantiomers' Binding Interactions With Prostaglandin (PG)-Protein: Implications for Inflammatory Activity in Cancer.
Tiwari, Cureus 2024 - “...human Pg protein was obtained from the FASTA sequences from the Uniport database with id P08183. The reference protein (PDB 3G60) was selected with the inhibitor for homology modeling and active sites were demonstrated in the Ramachandran Plot (Figure 1 ). FASTA sequences from the Uniport...”
- Isolation method of brain microvessels from small frozen human brain tissue for blood-brain barrier protein expression analysis.
Ogata, Fluids and barriers of the CNS 2024 - “...transporter ABCA9 Q8IUA7 Detected only in Bcap - ABCG2 (BCRP) Q9UNQ0 117 4.94E-05 ABCB1 (MDR1) P08183 112 1.38E-06 SLC transporter SLC12A7 (KCC4) Q9Y666 Detected only in Bcap - SLC19A1 (FLOT1) P41440 Detected only in Bcap - SLC38A5 (SNAT5) Q8WUX1 Detected only in Bcap - SLC6A12 P48065...”
- Network Pharmacology and Bioinformatics Analysis to Identify the Molecular Targets and its Biological Mechanisms of Sciadopitysin against Glioblastoma.
Lian, Journal of Cancer 2024 - “...cassette sub-family G member 2 MCL1 Q07820 Induced myeloid leukemia cell differentiation protein Mcl-1 ABCB1 P08183 ATP-dependent translocase ABCB1 AKR1B1 P15121 Aldo-keto reductase family 1 member B1 PRKCB P05771 Protein kinase C beta type CYP19A1 P11511 Cytochrome P450 19A1 NOX4 Q9NPH5 NADPH oxidase 4 KDM1A O60341...”
- More
O46605 Multidrug resistance p-glycoprotein from Canis lupus familiaris
33% identity, 18% coverage
SGO_0983 amino acid transport protein SP0709 from Streptococcus gordonii str. Challis substr. CH1
29% identity, 89% coverage
ABCB1 / RF|NP_000918.2 multidrug resistance protein 1 from Homo sapiens
33% identity, 18% coverage
Q9X196 Spermidine/putrescine import ATP-binding protein PotA from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
35% identity, 47% coverage
FPV33_RS17200 glutamine ABC transporter ATP-binding protein GlnQ from Klebsiella aerogenes
29% identity, 91% coverage
TC_RS00120 LPS export ABC transporter ATP-binding protein from Chlamydia muridarum str. Nigg
TC0023 ABC transporter, ATP-binding protein from Chlamydia muridarum Nigg
27% identity, 95% coverage
4f4cA / P34712 The crystal structure of the multi-drug transporter (see paper)
30% identity, 17% coverage
- Ligand: undecyl 4-o-alpha-d-glucopyranosyl-1-thio-beta-d-glucopyranoside (4f4cA)
XP_005806663 ATP-binding cassette sub-family B member 9 from Xiphophorus maculatus
30% identity, 27% coverage
For advice on how to use these tools together, see
Interactive tools for functional annotation of bacterial genomes.
The PaperBLAST database links 789,361 different protein sequences to 1,256,019 scientific articles. Searches against EuropePMC were last performed on January 10 2025.
PaperBLAST builds a database of protein sequences that are linked
to scientific articles. These links come from automated text searches
against the articles in EuropePMC
and from manually-curated information from GeneRIF, UniProtKB/Swiss-Prot,
BRENDA,
CAZy (as made available by dbCAN),
BioLiP,
CharProtDB,
MetaCyc,
EcoCyc,
TCDB,
REBASE,
the Fitness Browser,
and a subset of the European Nucleotide Archive with the /experiment tag.
Given this database and a protein sequence query,
PaperBLAST uses protein-protein BLAST
to find similar sequences with E < 0.001.
To build the database, we query EuropePMC with locus tags, with RefSeq protein
identifiers, and with UniProt
accessions. We obtain the locus tags from RefSeq or from MicrobesOnline. We use
queries of the form "locus_tag AND genus_name" to try to ensure that
the paper is actually discussing that gene. Because EuropePMC indexes
most recent biomedical papers, even if they are not open access, some
of the links may be to papers that you cannot read or that our
computers cannot read. We query each of these identifiers that
appears in the open access part of EuropePMC, as well as every locus
tag that appears in the 500 most-referenced genomes, so that a gene
may appear in the PaperBLAST results even though none of the papers
that mention it are open access. We also incorporate text-mined links
from EuropePMC that link open access articles to UniProt or RefSeq
identifiers. (This yields some additional links because EuropePMC
uses different heuristics for their text mining than we do.)
For every article that mentions a locus tag, a RefSeq protein
identifier, or a UniProt accession, we try to select one or two
snippets of text that refer to the protein. If we cannot get access to
the full text, we try to select a snippet from the abstract, but
unfortunately, unique identifiers such as locus tags are rarely
provided in abstracts.
PaperBLAST also incorporates manually-curated protein functions:
- Proteins from NCBI's RefSeq are included if a
GeneRIF
entry links the gene to an article in
PubMed®.
GeneRIF also provides a short summary of the article's claim about the
protein, which is shown instead of a snippet.
- Proteins from Swiss-Prot (the curated part of UniProt)
are included if the curators
identified experimental evidence for the protein's function (evidence
code ECO:0000269). For these proteins, the fields of the Swiss-Prot entry that
describe the protein's function are shown (with bold headings).
- Proteins from BRENDA,
a curated database of enzymes, are included if they are linked to a paper in PubMed
and their full sequence is known.
- Every protein from the non-redundant subset of
BioLiP,
a database
of ligand-binding sites and catalytic residues in protein structures, is included. Since BioLiP itself
does not include descriptions of the proteins, those are taken from the
Protein Data Bank.
Descriptions from PDB rely on the original submitter of the
structure and cannot be updated by others, so they may be less reliable.
(For SitesBLAST and Sites on a Tree, we use a larger subset of BioLiP so that every
ligand is represented among a group of structures with similar sequences, but for
PaperBLAST, we use the non-redundant set provided by BioLiP.)
- Every protein from EcoCyc, a curated
database of the proteins in Escherichia coli K-12, is included, regardless
of whether they are characterized or not.
- Proteins from the MetaCyc metabolic pathway database
are included if they are linked to a paper in PubMed and their full sequence is known.
- Proteins from the Transport Classification Database (TCDB)
are included if they have known substrate(s), have reference(s),
and are not described as uncharacterized or putative.
(Some of the references are not visible on the PaperBLAST web site.)
- Every protein from CharProtDB,
a database of experimentally characterized protein annotations, is included.
- Proteins from the CAZy database of carbohydrate-active enzymes
are included if they are associated with an Enzyme Classification number.
Even though CAZy does not provide links from individual protein sequences to papers,
these should all be experimentally-characterized proteins.
- Proteins from the REBASE database
of restriction enzymes are included if they have known specificity.
- Every protein with an evidence-based reannotation (based on mutant phenotypes)
in the Fitness Browser is included.
- Sequence-specific transcription factors (including sigma factors and DNA-binding response regulators)
with experimentally-determined DNA binding sites from the
PRODORIC database of gene regulation in prokaryotes.
- Putative transcription factors from RegPrecise
that have manually-curated predictions for their binding sites. These predictions are based on
conserved putative regulatory sites across genomes that contain similar transcription factors,
so PaperBLAST clusters the TFs at 70% identity and retains just one member of each cluster.
- Coding sequence (CDS) features from the
European Nucleotide Archive (ENA)
are included if the /experiment tag is set (implying that there is experimental evidence for the annotation),
the nucleotide entry links to paper(s) in PubMed,
and the nucleotide entry is from the STD data class
(implying that these are targeted annotated sequences, not from shotgun sequencing).
Also, to filter out genes whose transcription or translation was detected, but whose function
was not studied, nucleotide entries or papers with more than 25 such proteins are excluded.
Descriptions from ENA rely on the original submitter of the
sequence and cannot be updated by others, so they may be less reliable.
Except for GeneRIF and ENA,
the curated entries include a short curated
description of the protein's function.
For entries from BioLiP, the protein's function may not be known beyond binding to the ligand.
Many of these entries also link to articles in PubMed.
For more information see the
PaperBLAST paper (mSystems 2017)
or the code.
You can download PaperBLAST's database here.
Changes to PaperBLAST since the paper was written:
- November 2023: incorporated PRODORIC and RegPrecise. Many PRODORIC entries were not linked to a protein sequence (no UniProt identifier), so we added this information.
- February 2023: BioLiP changed their download format. PaperBLAST now includes their non-redundant subset. SitesBLAST and Sites on a Tree use a larger non-redundant subset that ensures that every ligand is represented within each cluster. This should ensure that every binding site is represented.
- June 2022: incorporated some coding sequences from ENA with the /experiment tag.
- March 2022: incorporated BioLiP.
- April 2020: incorporated TCDB.
- April 2019: EuropePMC now returns table entries in their search results. This has expanded PaperBLAST's database, but most of the new entries are of low relevance, and the resulting snippets are often just lists of locus tags with annotations.
- February 2018: the alignment page reports the conservation of the hit's functional sites (if available from from Swiss-Prot or UniProt)
- January 2018: incorporated BRENDA.
- December 2017: incorporated MetaCyc, CharProtDB, CAZy, REBASE, and the reannotations from the Fitness Browser.
- September 2017: EuropePMC no longer returns some table entries in their search results. This has shrunk PaperBLAST's database, but has also reduced the number of low-relevance hits.
Many of these changes are described in Interactive tools for functional annotation of bacterial genomes.
PaperBLAST cannot provide snippets for many of the papers that are
published in non-open-access journals. This limitation applies even if
the paper is marked as "free" on the publisher's web site and is
available in PubmedCentral or EuropePMC. If a journal that you publish
in is marked as "secret," please consider publishing elsewhere.
Many important articles are missing from PaperBLAST, either because
the article's full text is not in EuropePMC (as for many older
articles), or because the paper does not mention a protein identifier such as a locus tag, or because of PaperBLAST's heuristics. If you notice an
article that characterizes a protein's function but is missing from
PaperBLAST, please notify the curators at UniProt
or add an entry to GeneRIF.
Entries in either of these databases will eventually be incorporated
into PaperBLAST. Note that to add an entry to UniProt, you will need
to find the UniProt identifier for the protein. If the protein is not
already in UniProt, you can ask them to create an entry. To add an
entry to GeneRIF, you will need an NCBI Gene identifier, but
unfortunately many prokaryotic proteins in RefSeq do not have
corresponding Gene identifers.
References
PaperBLAST: Text-mining papers for information about homologs.
M. N. Price and A. P. Arkin (2017). mSystems, 10.1128/mSystems.00039-17.
Europe PMC in 2017.
M. Levchenko et al (2017). Nucleic Acids Research, 10.1093/nar/gkx1005.
Gene indexing: characterization and analysis of NLM's GeneRIFs.
J. A. Mitchell et al (2003). AMIA Annu Symp Proc 2003:460-464.
UniProt: the universal protein knowledgebase.
The UniProt Consortium (2016). Nucleic Acids Research, 10.1093/nar/gkw1099.
BRENDA in 2017: new perspectives and new tools in BRENDA.
S. Placzek et al (2017). Nucleic Acids Research, 10.1093/nar/gkw952.
The EcoCyc database: reflecting new knowledge about Escherichia coli K-12.
I. M. Keeseler et al (2016). Nucleic Acids Research, 10.1093/nar/gkw1003.
The MetaCyc database of metabolic pathways and enzymes.
R. Caspi et al (2018). Nucleic Acids Research, 10.1093/nar/gkx935.
CharProtDB: a database of experimentally characterized protein annotations.
R. Madupu et al (2012). Nucleic Acids Research, 10.1093/nar/gkr1133.
The carbohydrate-active enzymes database (CAZy) in 2013.
V. Lombard et al (2014). Nucleic Acids Research, 10.1093/nar/gkt1178.
The Transporter Classification Database (TCDB): recent advances
M. H. Saier, Jr. et al (2016). Nucleic Acids Research, 10.1093/nar/gkv1103.
REBASE - a database for DNA restriction and modification: enzymes, genes and genomes.
R. J. Roberts et al (2015). Nucleic Acids Research, 10.1093/nar/gku1046.
Deep annotation of protein function across diverse bacteria from mutant phenotypes.
M. N. Price et al (2016). bioRxiv, 10.1101/072470.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory