PaperBLAST
PaperBLAST Hits for SwissProt::Q84DC3 NAD(P)-dependent benzaldehyde dehydrogenase; EC 1.2.1.28; EC 1.2.1.7 (Pseudomonas putida (Arthrobacter siderocapsulatus)) (436 a.a., MNYLSPAKID...)
Show query sequence
>SwissProt::Q84DC3 NAD(P)-dependent benzaldehyde dehydrogenase; EC 1.2.1.28; EC 1.2.1.7 (Pseudomonas putida (Arthrobacter siderocapsulatus))
MNYLSPAKIDSLFSAQKAYFATRATADVGFRKQSLERLKEAVINNKEALYSALAEDLGKP
KDVVDLAEIGAVLHEIDFALAHLDEWVAPVSVPSPDIIAPSECYVVQEPYGVTYIIGPFN
YPVNLTLTPLIGAIIGGNTCIIKPSETTPETSAVIEKIIAEAFAPEYVAVIQGGRDENSH
LLSLPFDFIFFTGSPNVGKVVMQAAAKHLTPVVLELGGKCPLIVLPDADLDQTVNQLMFG
KFINSGQTCIAPDYLYVHYSVKDALLERLVERVKTELPEINSTGKLVTERQVQRLVSLLE
ATQGQVLVGSQADVSKRALSATVVDGVEWNDPLMSEELFGPILPVLEFDSVRTAIDQVNK
HHPKPLAVYVFGKDMDVAKGIINQIQSGDAQVNGVMLHAFSPYLPFGGIGASGMGEYHGH
FSYLTFTHKKSVRIVP
Running BLASTp...
Found 253 similar proteins in the literature:
mdlD / Q84DC3 NADP+-benzaldehyde dehydrogenase (EC 1.2.1.96; EC 1.2.1.7) from Pseudomonas putida (see 2 papers)
MDLD_PSEPU / Q84DC3 NAD(P)-dependent benzaldehyde dehydrogenase; EC 1.2.1.28; EC 1.2.1.7 from Pseudomonas putida (Arthrobacter siderocapsulatus) (see paper)
Q84DC3 benzaldehyde dehydrogenase (NAD+) (EC 1.2.1.28); benzaldehyde dehydrogenase (NADP+) (EC 1.2.1.7) from Pseudomonas putida (see paper)
WP_016501743 NAD(P)-dependent benzaldehyde dehydrogenase MdlD from Pseudomonas sp. SDS3-8
100% identity, 100% coverage
- function: NAD or NADP-dependent benzaldehyde dehydrogenase that catalyzes the conversion of benzaldehyde into benzoate in the (R)- mandelate degradation pathway.
catalytic activity: benzaldehyde + NAD(+) + H2O = benzoate + NADH + 2 H(+) (RHEA:11840)
catalytic activity: benzaldehyde + NADP(+) + H2O = benzoate + NADPH + 2 H(+) (RHEA:21660) - Engineering of a chromogenic enzyme screening system based on an auxiliary indole-3-carboxylic acid monooxygenase
Časaitė, MicrobiologyOpen 2019 - “...pALDBS21 515 Phenylacetaldehyde dehydrogenase Alcaligenes faecalis WP_045929579 96 pALDBSal 436 NAD(P)dependent benzaldehyde dehydrogenase Pseudomonas putida WP_016501743 99 pALDGA1 483 Salicylaldehyde dehydrogenase Afipia massiliensis WP_046830129 91 pALDJU6 488 Phenylacetaldehyde dehydrogenase Pseudomonas sp. MIACH WP_053136087 96 pALDMO9 485 Aldehyde dehydrogenase Bacillus thermoamylovorans WP_041902008 82 pALDMO11 487 Benzaldehyde dehydrogenase...”
5ucdA / Q84DC3 Benzaldehyde dehydrogenase, a class 3 aldehyde dehydrogenase, with bound NADP+ and benzoate adduct (see paper)
100% identity, 100% coverage
- Ligand: nadp nicotinamide-adenine-dinucleotide phosphate (5ucdA)
dpgC / A3RJV6 benzaldehyde dehydrogenase (EC 1.2.1.28) from Stutzerimonas stutzeri (see paper)
86% identity, 100% coverage
aldH / A0A0H3KDU5 4,4'-diaponeurosporenal dehydrogenase from Staphylococcus aureus (strain Newman) (see paper)
DIALD_STAA8 / Q2FWX9 4,4'-diaponeurosporen-aldehyde dehydrogenase; 4,4'-diaponeurosporenal dehydrogenase; EC 1.2.1.- from Staphylococcus aureus (strain NCTC 8325 / PS 47) (see paper)
NWMN_1858 aldehyde dehydrogenase from Staphylococcus aureus subsp. aureus str. Newman
SAOUHSC_02142 aldehyde dehydrogenase, putative from Staphylococcus aureus subsp. aureus NCTC 8325
SACOL1984 aldehyde dehydrogenase from Staphylococcus aureus subsp. aureus COL
CH51_RS10975 aldehyde dehydrogenase from Staphylococcus aureus
44% identity, 92% coverage
- function: Involved in the biosynthesis of the yellow-orange carotenoid staphyloxanthin, which plays a role in the virulence via its protective function against oxidative stress. Catalyzes the oxidation of 4,4'- diaponeurosporen-4-al to yield 4,4'-diaponeurosporenoic acid.
catalytic activity: 4,4'-diaponeurosporenal + NAD(+) + H2O = 4,4'- diaponeurosporenoate + NADH + 2 H(+) (RHEA:42384)
disruption phenotype: Cells lacking this gene are unable to produce staphyloxanthin and cause accumulation of 4,4'- diaponeurosporen-4-al. - Functional expression and extension of staphylococcal staphyloxanthin biosynthetic pathway in Escherichia coli
Kim, The Journal of biological chemistry 2012 - “...aldH asd gapA gapB gbsA NWMN_2026 NWMN_0113 NWMN_1858 NWMN_1305 NWMN_0741 NWMN_1580 NWMN_2510 Not assigned Not assigned Carotenoid biosynthesis (this study)...”
- Redox sensing by a Rex-family repressor is involved in the regulation of anaerobic gene expression in Staphylococcus aureus
Pagels, Molecular microbiology 2010 - “...SAOUHSC_01839 TyrS 1 (1.4) 1.3 (3.2) 0.8 (1.8) 1.6 (1.8) 1.3 (0.8) SACOL1778 Tyrosyl-tRNA synthetase SAOUHSC_02142 AldA2 4.5 (1.1) 0.5 (0.8) 1.1 (1.1) 0.4 (0.7) 4 (1) SACOL1984 Aldehyde dehydrogenase SAOUHSC_02441 Asp23 1 0.8 (0.6) 3 (2.5) 0.9 (0.8) 3.4 (3.3) 0.9 (0.8) SACOL2173 Alkaline shock...”
- Global analysis of the Staphylococcus aureus response to mupirocin
Reiss, Antimicrobial agents and chemotherapy 2012 - “...min 30 min 60 min c2 SACOL1385 SACOL1673 SACOL1984 SACOL2097 AcnA AlaS AldA2 AtpA Aconitate hydratase Alanyl-tRNA synthetase Aldehyde dehydrogenase ATP synthase...”
- Redox sensing by a Rex-family repressor is involved in the regulation of anaerobic gene expression in Staphylococcus aureus
Pagels, Molecular microbiology 2010 - “...SACOL1778 Tyrosyl-tRNA synthetase SAOUHSC_02142 AldA2 4.5 (1.1) 0.5 (0.8) 1.1 (1.1) 0.4 (0.7) 4 (1) SACOL1984 Aldehyde dehydrogenase SAOUHSC_02441 Asp23 1 0.8 (0.6) 3 (2.5) 0.9 (0.8) 3.4 (3.3) 0.9 (0.8) SACOL2173 Alkaline shock protein 23 SAOUHSC_02561 UreC 1.9 (1.4) 2.3 (3) 2 (1.9) 1.2 (1.6)...”
- Influence of the two-component system SaeRS on global gene expression in two different Staphylococcus aureus strains
Rogasch, Journal of bacteriology 2006 - “...36.3/4.6 71.3/9.6 35.3/9.1 SACOL0452 SACOL2666 SACOL1984 SACOL2659 SACOL0209 SACOL0857 SACOL0908 SACOL0593 SACOL0842 SACOL1180 SACOL2117 SACOL1782 SACOL0838...”
- Staphylococcus aureus PhoU Homologs Regulate Persister Formation and Virulence
Shang, Frontiers in microbiology 2020 - “...2.02 ND CH51_RS01035 Formate acetyltransferase 0.37 0.52 0.12 CH51_RS01095 Acyl CoA:acetate/3-ketoacid CoA transferase 2.74 ND CH51_RS10975 Aldehyde dehydrogenase 2.84 ND CH51_RS14295 Lactate dehydrogenase 0.43 ND CH51_RS04930 CoA-disulfide reductase 2.32 ND CH51_RS09730 Acetate-CoA ligase 2.31 ND CH51_RS14750 Acetyl-CoA synthetase 2.17 1.91 0.61 Glycolysis/gluconeogenesis CH51_RS03355 Zinc-dependent alcohol dehydrogenase...”
Dhaf_2181 Aldehyde Dehydrogenase from Desulfitobacterium hafniense DCB-2
44% identity, 93% coverage
SAR2013 putative aldehyde dehydrogenase from Staphylococcus aureus subsp. aureus MRSA252
44% identity, 92% coverage
- Staphylococcus aureus nitric oxide synthase (saNOS) modulates aerobic respiratory metabolism and cell physiology
Mogen, Molecular microbiology 2017 - “...). In addition, several metabolic genes, including those associated with anaerobic metabolism/fermentation ( pfl, narG, SAR2013, SAR2210 , and ldh2 ), pyruvate and carbohydrate metabolism ( pyk , lac operon, nanA , fda , gap, and pgi ), amino acid metabolism ( SAR1143 , otc ,...”
SA1736 aldehyde dehydrogenase from Staphylococcus aureus subsp. aureus N315
44% identity, 92% coverage
RCF35_18825 aldehyde dehydrogenase from Bacillus velezensis
45% identity, 93% coverage
- Whole genome sequencing data of the submerged macrophytes growth promoting and aerobic denitrifying bacterium Bacillus velezensis NBNZ-0060
Chen, Data in brief 2024 - “...RCF35_12695 ( pyc ), RCF35_01945, RCF35_07080, RCF35_07085 ( bsdC ) indole-3-acetaldehyde dehydrogenase RCF35_04555, RCF35_14870, RCF35_08890, RCF35_18825 tryptamine pathway tryptophan decarboxylase RCF35_07465, RCF35_12695 ( pyc ), RCF35_01945, RCF35_07080, RCF35_07085 ( bsdC ) indole-3-acetaldehyde dehydrogenase RCF35_04555, RCF35_14870, RCF35_08890, RCF35_18825 indole-3-acetonitrile pathway nitrilase RCF35_09895 Others tryptophan acetyltransferase RCF35_03780 Table...”
HWX41_RS25615 aldehyde dehydrogenase from Bacillus paramycoides
43% identity, 92% coverage
- Genomic Analysis of Endophytic Bacillus cereus T4S and Its Plant Growth-Promoting Traits
Adeleke, Plants (Basel, Switzerland) 2021 - “...HWX41_RS18055 IAA production, IPA pathway dha S aldehyde dehydrogenase Dha S HWX41_RS06485 dha aldehyde dehydrogenase HWX41_RS25615 dha acetaldehyde dehydrogenase (acetylating) HWX41_RS13995 dha aldehyde dehydrogenase family protein HWX41_RS19325 dha aldehyde dehydrogenase family protein HWX41_RS06850 dha aldehyde dehydrogenase family protein HWX41_RS10480 dha aldehyde dehydrogenase family protein HWX41_RS13000 dha...”
V529_29500 aldehyde dehydrogenase from Bacillus velezensis SQR9
45% identity, 93% coverage
- Analysis and cloning of the synthetic pathway of the phytohormone indole-3-acetic acid in the plant-beneficial Bacillus amyloliquefaciens SQR9
Shao, Microbial cell factories 2015 - “...padC (V529_34370), yclB (V529_03390), yclC (V529_03400) IAAld dehydrogenase aldX (V529_39560), dhaS (V529_19360), yfmT (V529_06950), ywdH (V529_29500) IAM Trp mono-oxygenase Not detected IAM hydrolase Not detected TAM Trp decarboxylase ydaP (V529_04190), pycA (V529_14260), padC (V529_34370), yclB (V529_03390), yclC (V529_03400) Amine oxidase Not detected IAAld dehydrogenase aldX (V529_39560),...”
GBAA1296 aldehyde dehydrogenase from Bacillus anthracis str. 'Ames Ancestor'
46% identity, 93% coverage
BC1285 Aldehyde dehydrogenase (NAD(P)+) from Bacillus cereus ATCC 14579
45% identity, 93% coverage
HWX41_RS17590 aldehyde dehydrogenase from Bacillus paramycoides
45% identity, 93% coverage
- Genomic Analysis of Endophytic Bacillus cereus T4S and Its Plant Growth-Promoting Traits
Adeleke, Plants (Basel, Switzerland) 2021 - “...dehydrogenase family protein HWX41_RS13000 dha aldehyde dehydrogenase family protein HWX41_RS17225 dha aldehyde dehydrogenase family protein HWX41_RS17590 dha aldehyde dehydrogenase family protein HWX41_RS14005 CK biosynthesis and transformation mia A tRNA (adenosine(37)-N6)-dimethylallyltransferase Mia A HWX41_RS05835 Ammonia production nad E ammonia-dependent NAD(+) synthetase HWX41_RS14365 Key: NDnot determined. plants-10-01776-t006_Table 6...”
Cphy_3041 Aldehyde Dehydrogenase_ from Clostridium phytofermentans ISDg
42% identity, 92% coverage
Npun_F0840 aldehyde dehydrogenase from Nostoc punctiforme
43% identity, 93% coverage
- High Light Induced Alka(e)ne Biodegradation for Lipid and Redox Homeostasis in Cyanobacteria
Qiao, Frontiers in microbiology 2020 - “...QY8 E. coli BL21(DE3) with pET28a- Synpcc7942_0489 This study QY9 E. coli BL21(DE3) with pET28a- Npun_F0840 This study JZ8 E. coli BL21(DE3) with pET28a- Npun_R1711 Our laboratory JZ17 E. coli BL21(DE3) with pET28a- Synpcc7942_1593 Our laboratory Syn6803, Synechocystis sp. PCC 6803 Prof. Xudong Xu Syn7942, Synechococcus...”
- “...) and ALDH ( Synpcc7942_0489 ) from Syn7942, ADO ( Npun_R1711 ) and ALDH ( Npun_F0840 ) from Nos73102 were overexpressed in E. coli BL21(DE3) in LB medium with an N-terminal histidine tag in pET28a (Novagen, Germany). Protein expression was induced using 0.2 mM IPTG at...”
SE1603 aldehyde dehydrogenase from Staphylococcus epidermidis ATCC 12228
41% identity, 92% coverage
FQ085_01960 aldehyde dehydrogenase from Planococcus sp. ANT_H30
40% identity, 94% coverage
DCF50_p2406 aldehyde dehydrogenase from Dehalobacter sp. CF
42% identity, 94% coverage
alr3672 aldehyde dehydrogenase from Nostoc sp. PCC 7120
41% identity, 94% coverage
- Bioinformatic evaluation of L-arginine catabolic pathways in 24 cyanobacteria and transcriptional analysis of genes encoding enzymes of L-arginine catabolism in the cyanobacterium Synechocystis sp. PCC 6803
Schriek, BMC genomics 2007 - “...Gll2805 Nostoc sp. PCC 7120 Alr7169 Alr2310 Alr2398, Alr1080, All0396, Alr3265 Alr3771, All3556, Alr0540, All5022, Alr3672 Nostoc punctiforme PCC 73102 Npun02003735 Npun02002114 Npun02005728, Npun02001509, Npun02001164, Npun02002747 Npun02003702, Npun02002895, Npun02002692, Npun02005276 Anabaena variabilis ATCC 29413 n.d. Ava_0127 Ava_0214, Ava_3730, Ava_2839, Ava_4920 Ava_1554, Ava_3534, Ava_2942, Ava_2258, Ava_3615 N.d....”
Ava_3615 Aldehyde dehydrogenase from Anabaena variabilis ATCC 29413
41% identity, 94% coverage
- Bioinformatic evaluation of L-arginine catabolic pathways in 24 cyanobacteria and transcriptional analysis of genes encoding enzymes of L-arginine catabolism in the cyanobacterium Synechocystis sp. PCC 6803
Schriek, BMC genomics 2007 - “...Npun02005276 Anabaena variabilis ATCC 29413 n.d. Ava_0127 Ava_0214, Ava_3730, Ava_2839, Ava_4920 Ava_1554, Ava_3534, Ava_2942, Ava_2258, Ava_3615 N.d. = not detected. L-arginine decarboxylase pathway One or several genes encoding L-arginine decarboxylase-type enzymes, which catalyze the formation of agmatine from L-arginine, are present in all investigated cyanobacteria (Fig....”
CD2206 aldehyde dehydrogenase from Clostridium difficile 630
40% identity, 93% coverage
NP_504634 Aldehyde dehydrogenase from Caenorhabditis elegans
41% identity, 85% coverage
CwatDRAFT_1032 Aldehyde dehydrogenase from Crocosphaera watsonii WH 8501
42% identity, 92% coverage
- Bioinformatic evaluation of L-arginine catabolic pathways in 24 cyanobacteria and transcriptional analysis of genes encoding enzymes of L-arginine catabolism in the cyanobacterium Synechocystis sp. PCC 6803
Schriek, BMC genomics 2007 - “...n.d RS9917_11395 n.d RS9917_02641 Crocosphaera watsonii WH 8501 CwatDRAFT_1880 n.d n.d CwatDRAFT_4111 n.d CwatDRAFT_2611CwatDRAFT_0842 CwatDRAFT_0969 CwatDRAFT_1032 Trichodesmium erythraeum IMS 101 TeryDRAFT_0894, TeryDRAFT_0959, TeryDRAFT_0311 TeryDRAFT4567 n.d TeryDRAFT_0835 n.d TeryDRAFT_3296, TeryDRAFT_3923 Freshwater species Synechococcus elongatus sp. PCC 6301 Syc0823_d, Syc0510_c n.d SYC1703_c, SYC1643_d Syc1946_d, Syc1745_c n.d Syc1030_d Synechococcus...”
- “...RS9917_05240, RS9917_02041, RS9917_09251 RS9917_02641 Crocosphaera watsonii WH 8501 n.d. n.d. CwatDRAFT_5161, CwatDRAFT_2647 CwatDRAFT_0842, CwatDRAFT_0969, CwatDRAFT_0865, CwatDRAFT_1032 Trichodesmium erythraeum IMS 101 TeryDRAFT_0956 TeryDRAFT4567 TeryDRAFT_3251, TeryDRAFT_3173 TeryDRAFT_3296, TeryDRAFT_3923, TeryDRAFT_3248 Enzymes C1 C2 C3* C4** Freshwater species Synechococcus elongatus sp. PCC 6301 Syc0596_c, Syc1144_c n.d. Syc0599_c, Syc1466_c, Syc0881_c Syc1030_d...”
ABO_2709 aldehyde dehydrogenase (NAD) from Alcanivorax borkumensis SK2
41% identity, 87% coverage
Cbei_1953 aldehyde dehydrogenase from Clostridium beijerincki NCIMB 8052
38% identity, 92% coverage
- Sigma Factor Regulated Cellular Response in a Non-solvent Producing Clostridium beijerinckii Degenerated Strain: A Comparative Transcriptome Analysis
Zhang, Frontiers in microbiology 2017 - “...to -4.91, -20.78, -10.83 (solventogenesis), respectively. In DG-8052, there had several aldA copes (aldehyde dehydrogenase, Cbei_1953, Cbei_3832, Cbei_0674, and Cbei_2518), which probes were all down-regulated, especially Cbei_0674 (-50.64, -40.26) (Supplementary Table S5f ). In addition, acetoacetate decarboxylase (Cbei_3835, -23.22, -22.99) was greatly down-regulated as well. While...”
- Development of a gene knockout system using mobile group II introns (Targetron) and genetic disruption of acid production pathways in Clostridium beijerinckii
Wang, Applied and environmental microbiology 2013 - “...acidogenesis phase. dehydrogenase (Cbei_0727 and Cbei_1953), cysteine synthase (Cbei_4356, Cbei_0577, Cbei_0622, and Cbei_0630), and acetylornithine deacetylase...”
Syncc9605_0497 putative aldehyde dehydrogenase from Synechococcus sp. CC9605
41% identity, 93% coverage
- Bioinformatic evaluation of L-arginine catabolic pathways in 24 cyanobacteria and transcriptional analysis of genes encoding enzymes of L-arginine catabolism in the cyanobacterium Synechocystis sp. PCC 6803
Schriek, BMC genomics 2007 - “...PMN2A_1287 n.d PMN2A_0052 n.d PMN2A_1709 Synechococcus sp. CC 9605 Syncc9605_1621, Syncc9605_2513 Syncc9605_1082Syncc9605_2591 n.d Syncc9605_1134 n.d Syncc9605_0497 Synechococcus sp. CC 9902 Syncc9902_1380, Syncc9902_2172 Syncc9902_2230 n.d Syncc9902_1323 n.d Syncc9902_1838 Synechococcus sp. WH 8102 SYNW0944, SYNW2359 SYNW1412, SYNW2422 n.d SYNW1008 n.d SYNW_1956 Synechococcus sp. WH 7805 WH7805_04481, WH7805_10353 WH7805_09974...”
- “...NATL 2A PMN2A_1287 PMN2A_0867, PMN2A_1003 PMN2A_1709 Synechococcus sp. CC 9605 Syncc9605_1082, Syncc9605_2591 Syncc9605_0858, Syncc9605_2052, Syncc9605_0659 Syncc9605_0497 Synechococcus sp. CC 9902 Syncc9902_2230 Syncc9902_1534, Syncc9902_0620 Syncc9902_1838 Synechococcus sp. WH 8102 SYNW1412, SYNW2422 SYNW1634, SYNW0629 SYNW1956 Synechococcus sp. WH 7805 WH7805_06086, WH7805_09974 WH7805_05656, WH7805_12388, WH7805_13803 WH7805_06416 Synechococcus sp. WH...”
WH5701_06196 Putative aldehyde dehydrogenase from Synechococcus sp. WH 5701
42% identity, 84% coverage
- Bioinformatic evaluation of L-arginine catabolic pathways in 24 cyanobacteria and transcriptional analysis of genes encoding enzymes of L-arginine catabolism in the cyanobacterium Synechocystis sp. PCC 6803
Schriek, BMC genomics 2007 - “...WH7805_01902 n.d n.d Synechococcus sp. WH 5701 WH5701_04905, WH5701_10310 WH5701_03684, WH5701_03860 n.d WH5701_10020, WH5701_10155 n.d WH5701_06196 Synechococcus sp. RS 9917 RS9917_01007, RS9917_06495 RS9917_06190 n.d RS9917_11395 n.d RS9917_02641 Crocosphaera watsonii WH 8501 CwatDRAFT_1880 n.d n.d CwatDRAFT_4111 n.d CwatDRAFT_2611CwatDRAFT_0842 CwatDRAFT_0969 CwatDRAFT_1032 Trichodesmium erythraeum IMS 101 TeryDRAFT_0894, TeryDRAFT_0959, TeryDRAFT_0311...”
- “...7805 WH7805_06086, WH7805_09974 WH7805_05656, WH7805_12388, WH7805_13803 WH7805_06416 Synechococcus sp. WH 5701 WH5701_03684, WH5701_03860 WH5701_07406, WH5701_15376 WH5701_06196 Synechococcus sp. RS 9917 RS9917_06190 RS9917_02041, RS9917_05240 RS9917_02641 Crocosphaera watsonii WH 8501 n.d. CwatDRAFT_5161 CwatDRAFT_0865, CwatDRAFT_0842, CwatDRAFT_0969 Trichodesmium erythraeum IMS 101 TeryDRAFT_4567 TeryDRAFT_3251 TeryDRAFT_2672 TeryDRAFT_3296, TeryDRAFT_3923 Freshwater species Synechococcus elongatus...”
Syncc9902_1838 putative aldehyde dehydrogenase from Synechococcus sp. CC9902
42% identity, 89% coverage
- Bioinformatic evaluation of L-arginine catabolic pathways in 24 cyanobacteria and transcriptional analysis of genes encoding enzymes of L-arginine catabolism in the cyanobacterium Synechocystis sp. PCC 6803
Schriek, BMC genomics 2007 - “...Syncc9605_1082Syncc9605_2591 n.d Syncc9605_1134 n.d Syncc9605_0497 Synechococcus sp. CC 9902 Syncc9902_1380, Syncc9902_2172 Syncc9902_2230 n.d Syncc9902_1323 n.d Syncc9902_1838 Synechococcus sp. WH 8102 SYNW0944, SYNW2359 SYNW1412, SYNW2422 n.d SYNW1008 n.d SYNW_1956 Synechococcus sp. WH 7805 WH7805_04481, WH7805_10353 WH7805_09974 n.d WH7805_01902 n.d n.d Synechococcus sp. WH 5701 WH5701_04905, WH5701_10310 WH5701_03684,...”
- “...CC 9605 Syncc9605_1082, Syncc9605_2591 Syncc9605_0858, Syncc9605_2052, Syncc9605_0659 Syncc9605_0497 Synechococcus sp. CC 9902 Syncc9902_2230 Syncc9902_1534, Syncc9902_0620 Syncc9902_1838 Synechococcus sp. WH 8102 SYNW1412, SYNW2422 SYNW1634, SYNW0629 SYNW1956 Synechococcus sp. WH 7805 WH7805_06086, WH7805_09974 WH7805_05656, WH7805_12388, WH7805_13803 WH7805_06416 Synechococcus sp. WH 5701 WH5701_03684, WH5701_03860 WH5701_07406, WH5701_15376 WH5701_06196 Synechococcus sp....”
PMT0191 Putative aldehyde dehydrogenase from Prochlorococcus marinus str. MIT 9313
43% identity, 88% coverage
- Bioinformatic evaluation of L-arginine catabolic pathways in 24 cyanobacteria and transcriptional analysis of genes encoding enzymes of L-arginine catabolism in the cyanobacterium Synechocystis sp. PCC 6803
Schriek, BMC genomics 2007 - “...PMT9312_1779 n.d PMT9312_0615 n.d PMT9312_0337 Prochlorococcus marinus MIT 9313 PMT1066, PMT2150 PMT2214 n.d PMT0395 n.d PMT0191 Prochlorococcus marinus MED 4 PMM1084, PMM0045 PMM1686 n.d PMM0615 n.d PMM1215, PMM0331 Prochlorococcus marinus NATL 2A PMN2A_0665, PMN2A_1378 PMN2A_1287 n.d PMN2A_0052 n.d PMN2A_1709 Synechococcus sp. CC 9605 Syncc9605_1621, Syncc9605_2513 Syncc9605_1082Syncc9605_2591...”
- “...Prochlorococcus marinus MIT 9312 PMT9312_1779 PMT9312_1397, PMT9312_1565 PMT9312_0337 Prochlorococcus marinus MIT 9313 PMT2214 PMT0331, PMT1493 PMT0191 Prochlorococcus marinus MED 4 PMM1686 PMM1301, PMM1472 PMM0331 Prochlorococcus marinus NATL 2A PMN2A_1287 PMN2A_0867, PMN2A_1003 PMN2A_1709 Synechococcus sp. CC 9605 Syncc9605_1082, Syncc9605_2591 Syncc9605_0858, Syncc9605_2052, Syncc9605_0659 Syncc9605_0497 Synechococcus sp. CC 9902...”
WP_010873792 aldehyde dehydrogenase family protein from Synechocystis sp. PCC 6803
slr0091 aldehyde dehydrogenase from Synechocystis sp. PCC 6803
40% identity, 93% coverage
- Construction of a Stable and Temperature-Responsive Yeast Cell Factory for Crocetin Biosynthesis Using CRISPR-Cas9
Liu, Frontiers in bioengineering and biotechnology 2020 - “...; Costantina et al., 2018 ) from Synechocystis sp. PCC6803 ( syaldh ; accession number: WP_010873792 ) and C. sativus L. ( CsALDH ; accession number: MF596165.1 ) were codon optimized and synthesized by Tsingke Biotech ( Table S1 ). All these genes were cloned into...”
- Novel candidate genes for environmental stresses response in Synechocystis sp. PCC 6803 revealed by machine learning algorithms
Karimi-Fard, Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] 2024 (PubMed)- “...Seven candidate genes namely sll1862, slr0650, sll0760, slr0091, ssl3044, slr1285, and slr1687 were selected by both LASSO and SVM-RFE algorithms. RNA-seq...”
- “...slr1285, sll1862, slr1674, sll0760, slr1392, slr1687, sll1863, slr0650, slr0091, and ssl3044. The Fig. 3, shows that slr1285 is the most important gene selected...”
- Incorporation, fate, and turnover of free fatty acids in cyanobacteria
Kahn, FEMS microbiology reviews 2023 - “...synpcc7942_0489 encoding ALDH) (Kaiser et al. 2013 ), as well as in Synechocystis 6803 ( slr0091 encoding ALDH) (Trautmann et al. 2013 ). They were shown to utilize long-chain fatty aldehydes, as well as shorter-chain length FAs in Synechococcus 7942 (C8C12) (Kaiser et al. 2013 )....”
- “...occurring in Synechocystis 6803 cells. They observed, in engineered strains overexpressing Aar/Ado (but not the slr0091) grown under high-light, an increased amount of fatty-aldehyde and an accumulation of reactive oxygen species. The authors suggest that these changes are responsible for the concomitant cell bleaching that was...”
- High Light Induced Alka(e)ne Biodegradation for Lipid and Redox Homeostasis in Cyanobacteria
Qiao, Frontiers in microbiology 2020 - “...Aukema et al., 2013 ). In addition, an aldehyde dehydrogenase (ALDH, EC 1.2.1.5) encoded by slr0091 in Synechocystis sp. PCC 6803 (hereafter Syn6803) can convert aldehydes to the corresponding fatty acids. It was shown that the transcript level of ado increased notably, while transcript level of...”
- “...Williams, 1988 ) to generate the QY4 strain. On that basis, one additional copy of slr0091 ( aldh ) was integrated into the slr1556 site (a redundant D-lactate dehydrogenase homolog) ( Angermayr et al., 2016 ) of the QY4 strain to generate the QY7 strain (...”
- Photosynthetic Conversion of Carbon Dioxide to Oleochemicals by Cyanobacteria: Recent Advances and Future Perspectives
Wang, Frontiers in microbiology 2020 - “...cyanobacterial aldehyde dehydrogenases (AldE), namely Synpcc7942_0489 from Syn7942 ( Kaiser et al., 2013 ) and Slr0091 from Syn6803 ( Trautmann et al., 2013 ), were proven sufficient to oxidize fatty aldehyde precursors into fatty acids ( Figure 2 ). It is noteworthy that these two aldehyde...”
- “...13510 . 10.1038/s41598-018-31789-5 30201972 Trautmann D. Beyer P. Al-Babili S. ( 2013 ). The ORF slr0091 of Synechocystis sp. PCC6803 encodes a high-light induced aldehyde dehydrogenase converting apocarotenals and alkanals. FEBS J. 280 3685 3696 . 10.1111/febs.12361 23734995 Verma E. Chakraborty S. Tiwari B. Mishra A....”
- On the use of oxygenic photosynthesis for the sustainable production of commodity chemicals
Pérez, Physiologia plantarum 2019 - “...reductases and dehydrogenases from the genome of Synechocystis sp. PCC 6803 were targeted (slr0942, sll0990, slr0091 and slr1192). Their reading frames were verified in silico to contain an NADPHbinding motif and share homology with known reductases/dehydrogenases from cyanobacteria and chemotrophic bacteria. The results of this report...”
- “...with CRISPRi/dCas9 yielded a greater than 10fold repression of all targets, with the exception of slr0091 which only exhibited twofold repression. The latter was attributed to inefficient abrogation of RNA polymerase elongation, because of an unknown promotor; CRISPRi/dCas9directed repression is less effective the greater the distance...”
- Emerging Species and Genome Editing Tools: Future Prospects in Cyanobacterial Synthetic Biology
Gale, Microorganisms 2019 - “...slr0942 , sll0990 , and slr1192 , but more modest knock down of 50% for slr0091 . Thus, validation of gRNA(s) is important to ensure effective transcriptional repression, which can be time consuming. To achieve more robust and consistent down regulation, it may be advantageous to...”
- Deletion of sll1541 in Synechocystis sp. Strain PCC 6803 Allows Formation of a Far-Red-Shifted holo-Proteorhodopsin In Vivo
Chen, Applied and environmental microbiology 2018 - “...in vivo role of five genes (sll1541; slr1648; slr0091; slr1192; slr0574) 25 potentially involved in retinal metabolism in Synechocystis sp. PCC6803. With a gene...”
- “...Deletion of gene slr0574 (encoding CYP120A1), but 32 not of slr0091, nor of slr1192 - relative to the level in wild type Synechocystis - causes an increase in...”
- Regulatory Tools for Controlling Gene Expression in Cyanobacteria
Gordon, Advances in experimental medicine and biology 2018 - “...of four targets at the same time. Repression of one target in PCC 6803 ( slr0091 ) was only 2-fold whereas other targets were about 10-fold. This weak repression could have been because this gene is very weakly transcribed than the others, or because it is...”
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Synpcc7942_0489 aldehyde dehydrogenase from Synechococcus elongatus PCC 7942
42% identity, 93% coverage
- Incorporation, fate, and turnover of free fatty acids in cyanobacteria
Kahn, FEMS microbiology reviews 2023 - “...aldehyde precursors into FFAs has been reported by Kaiser and colleagues in Synechococcus 7942 ( synpcc7942_0489 encoding ALDH) (Kaiser et al. 2013 ), as well as in Synechocystis 6803 ( slr0091 encoding ALDH) (Trautmann et al. 2013 ). They were shown to utilize long-chain fatty aldehydes,...”
- High Light Induced Alka(e)ne Biodegradation for Lipid and Redox Homeostasis in Cyanobacteria
Qiao, Frontiers in microbiology 2020 - “...used in this work. Strains Genotype Source or study QY8 E. coli BL21(DE3) with pET28a- Synpcc7942_0489 This study QY9 E. coli BL21(DE3) with pET28a- Npun_F0840 This study JZ8 E. coli BL21(DE3) with pET28a- Npun_R1711 Our laboratory JZ17 E. coli BL21(DE3) with pET28a- Synpcc7942_1593 Our laboratory Syn6803,...”
- “...Expression and Purification of the Recombinant Proteins Aldehyde-deformylating oxygenase ( Synpcc7942_1593 ) and ALDH ( Synpcc7942_0489 ) from Syn7942, ADO ( Npun_R1711 ) and ALDH ( Npun_F0840 ) from Nos73102 were overexpressed in E. coli BL21(DE3) in LB medium with an N-terminal histidine tag in pET28a...”
- Photosynthetic Conversion of Carbon Dioxide to Oleochemicals by Cyanobacteria: Recent Advances and Future Perspectives
Wang, Frontiers in microbiology 2020 - “...for endogenous FFAs biosynthesis in Syn6803. Besides the lipase, two cyanobacterial aldehyde dehydrogenases (AldE), namely Synpcc7942_0489 from Syn7942 ( Kaiser et al., 2013 ) and Slr0091 from Syn6803 ( Trautmann et al., 2013 ), were proven sufficient to oxidize fatty aldehyde precursors into fatty acids (...”
- Bioinformatic evaluation of L-arginine catabolic pathways in 24 cyanobacteria and transcriptional analysis of genes encoding enzymes of L-arginine catabolism in the cyanobacterium Synechocystis sp. PCC 6803
Schriek, BMC genomics 2007 - “...n.d Syc1030_d Synechococcus elongatus sp. PCC 7942 Synpcc7942_0707, Synpcc7942_1037 n.d Synpcc79422402 Synpcc79422461 Synpcc79422145 Synpcc79422358 n.d Synpcc7942_0489 Synechococcus Yellowstone sp. JA-3-3-AB CYA_1002, CYA_0128 CYA_0859 n.d CYA_0558 n.d CYA_0364 Synechococcus Yellowstone sp. JA-2-3Ba (2-13) CYB_2779, CYB_0482 CYB_1744 n.d CYB_1181 n.d CYB_0715, CYB_1893 Thermosynechococcus elongatus BP-1 Tlr1866, Tll1807 n.d....”
- “...sp. PCC 6301 n.d. Syc0599_c, Syc1466_c Syc1030_d Synechococcus elongatus sp. PCC 7942 n.d. Synpcc7942_0943, Synpcc7942_0031 Synpcc7942_0489 Synechococcus Yellowstone sp. JA-3-3-AB CYA_0859 CYA_1537, CYA_0689 CYA_0364 Synechococcus Yellowstone sp. JA-2-3Ba (2-13) CYB_1744 CYB_1419, CYB_2128 CYB_0516, CYB_0715, CYB_1893 Thermosynechococcus elongatus BP-1 n.d. Tlr1328, Tlr0408, Tll1935 Tlr0416, Tlr0221 Synechocystis sp....”
Q7ZU10 Aldehyde dehydrogenase from Danio rerio
39% identity, 88% coverage
- Progressive Motor and Non-Motor Symptoms in Park7 Knockout Zebrafish
Chavali, International journal of molecular sciences 2023 - “...25.20 Complex I assembly A0A0R4IQ88 D-glutamate cyclase dglucy 0.0012 0.27 22.68 24.50 Metabolization od D-glutamate Q7ZU10 Aldehyde dehydrogenase aldh3b1 0.0135 0.47 17.71 18.61 B3DJF3 3-phosphoadenosine-5-phosphosulfate synthase papss1 0.0004 0.49 20.44 21.22 Chaperone activity A0A2R8RNM0 Mitochondrial import inner membrane translocase timm8a 0.0249 3.37 20.11 18.19 Mitochondrial transcriptional...”
RS9917_02641 Putative aldehyde dehydrogenase from Synechococcus sp. RS9917
40% identity, 86% coverage
- Bioinformatic evaluation of L-arginine catabolic pathways in 24 cyanobacteria and transcriptional analysis of genes encoding enzymes of L-arginine catabolism in the cyanobacterium Synechocystis sp. PCC 6803
Schriek, BMC genomics 2007 - “...n.d WH5701_10020, WH5701_10155 n.d WH5701_06196 Synechococcus sp. RS 9917 RS9917_01007, RS9917_06495 RS9917_06190 n.d RS9917_11395 n.d RS9917_02641 Crocosphaera watsonii WH 8501 CwatDRAFT_1880 n.d n.d CwatDRAFT_4111 n.d CwatDRAFT_2611CwatDRAFT_0842 CwatDRAFT_0969 CwatDRAFT_1032 Trichodesmium erythraeum IMS 101 TeryDRAFT_0894, TeryDRAFT_0959, TeryDRAFT_0311 TeryDRAFT4567 n.d TeryDRAFT_0835 n.d TeryDRAFT_3296, TeryDRAFT_3923 Freshwater species Synechococcus elongatus sp....”
- “...sp. WH 5701 WH5701_03684, WH5701_03860 WH5701_07406, WH5701_15376 WH5701_06196 Synechococcus sp. RS 9917 RS9917_06190 RS9917_02041, RS9917_05240 RS9917_02641 Crocosphaera watsonii WH 8501 n.d. CwatDRAFT_5161 CwatDRAFT_0865, CwatDRAFT_0842, CwatDRAFT_0969 Trichodesmium erythraeum IMS 101 TeryDRAFT_4567 TeryDRAFT_3251 TeryDRAFT_2672 TeryDRAFT_3296, TeryDRAFT_3923 Freshwater species Synechococcus elongatus sp. PCC 6301 n.d. Syc0599_c, Syc1466_c Syc1030_d Synechococcus...”
AL3B1_HUMAN / P43353 Aldehyde dehydrogenase family 3 member B1; Aldehyde dehydrogenase 7; Long-chain fatty aldehyde dehydrogenase; Medium-chain fatty aldehyde dehydrogenase; EC 1.2.1.28; EC 1.2.1.5; EC 1.2.1.7; EC 1.2.1.48 from Homo sapiens (Human) (see 2 papers)
P43353 aldehyde dehydrogenase [NAD(P)+] (EC 1.2.1.5) from Homo sapiens (see paper)
NP_001154945 aldehyde dehydrogenase family 3 member B1 isoform a from Homo sapiens
41% identity, 90% coverage
- function: Oxidizes medium and long chain saturated and unsaturated fatty aldehydes generated in the plasma membrane into non-toxic fatty acids (PubMed:17382292, PubMed:23721920). May have a protective role against the cytotoxicity induced by lipid peroxidation (PubMed:17382292). Short-chain fatty aldehydes are not good substrates (PubMed:17382292). Can use both NADP(+) and NAD(+) as electron acceptor in vitro, however in vivo preference will depend on their tissue levels (PubMed:17382292). Low activity towards acetaldehyde and 3,4- dihydroxyphenylacetaldehyde (PubMed:17382292, PubMed:23721920). Able to metabolize aromatic aldehydes such as benzaldehyde to their acid form (PubMed:17382292).
catalytic activity: an aldehyde + NADP(+) + H2O = a carboxylate + NADPH + 2 H(+) (RHEA:11888)
catalytic activity: an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+) (RHEA:16185)
catalytic activity: a long-chain fatty aldehyde + NAD(+) + H2O = a long-chain fatty acid + NADH + 2 H(+) (RHEA:10652)
catalytic activity: a medium-chain fatty aldehyde + NAD(+) + H2O = a medium-chain fatty acid + NADH + 2 H(+) (RHEA:69763)
catalytic activity: octanal + NAD(+) + H2O = octanoate + NADH + 2 H(+) (RHEA:44100)
catalytic activity: nonanal + NAD(+) + H2O = nonanoate + NADH + 2 H(+) (RHEA:69759)
catalytic activity: hexadecanoate + NADH + 2 H(+) = hexadecanal + NAD(+) + H2O (RHEA:33739)
catalytic activity: (2E)-octenal + NAD(+) + H2O = (2E)-octenoate + NADH + 2 H(+) (RHEA:59920)
catalytic activity: (E)-non-2-enal + NAD(+) + H2O = (E)-non-2-enoate + NADH + 2 H(+) (RHEA:69767)
catalytic activity: (E)-4-hydroxynon-2-enal + NAD(+) + H2O = (E)-4-hydroxynon-2- enoate + NADH + 2 H(+) (RHEA:67248)
catalytic activity: (2E)-hexadecenal + NAD(+) + H2O = (E)-hexadec-2-enoate + NADH + 2 H(+) (RHEA:36135)
catalytic activity: benzaldehyde + NAD(+) + H2O = benzoate + NADH + 2 H(+) (RHEA:11840)
catalytic activity: a medium-chain fatty aldehyde + NADP(+) + H2O = a medium-chain fatty acid + NADPH + 2 H(+) (RHEA:80815)
catalytic activity: hexanal + NADP(+) + H2O = hexanoate + NADPH + 2 H(+) (RHEA:59908)
catalytic activity: octanal + NADP(+) + H2O = octanoate + NADPH + 2 H(+) (RHEA:59904)
catalytic activity: nonanal + NADP(+) + H2O = nonanoate + NADPH + 2 H(+) (RHEA:80819)
catalytic activity: (2E)-octenal + NADP(+) + H2O = (2E)-octenoate + NADPH + 2 H(+) (RHEA:59916)
catalytic activity: (E)-non-2-enal + NADP(+) + H2O = (E)-non-2-enoate + NADPH + 2 H(+) (RHEA:60692)
catalytic activity: (E)-4-hydroxynon-2-enal + NADP(+) + H2O = (E)-4-hydroxynon-2- enoate + NADPH + 2 H(+) (RHEA:59912)
catalytic activity: benzaldehyde + NADP(+) + H2O = benzoate + NADPH + 2 H(+) (RHEA:21660) - A crucial active site network of titratable residues guides catalysis and NAD<sup>+</sup> binding in human succinic semialdehyde dehydrogenase
Cesaro, Protein science : a publication of the Protein Society 2025 (no snippet) - Analysis of the mechanism of curcumin against osteoarthritis using metabolomics and transcriptomics.
Deng, Naunyn-Schmiedeberg's archives of pharmacology 2024 - “...of osteoarthritis No Target Uniprot id Protein name 1 CBS P35520 Cystathionine beta-synthase 2 ALDH3B1 P43353 Aldehyde dehydrogenase family 3 member B1 3 AOC2 O75106 Retina-specific copper amine oxidase 4 CTH P32929 Cystathionine gamma-lyase 5 MAOA P21397 Amine oxidase [flavin-containing] A 6 PSAT1 Q9Y617 Phosphoserine aminotransferase...”
- Characterization of human oxidoreductases involved in aldehyde odorant metabolism.
Boichot, Scientific reports 2023 - “...Apoptosis-inducing Factor 2 Q9BRQ8 1 (2, 2, 0) Aldehyde dehydrogenase family 3 member B1 (ALDH3B1) P43353 3 (0, 3, 0) Glutaredoxin-1 P35754 2 (2, 1, 0) 3-Oxo-5-beta-steroid 4-dehydrogenase (AKR1D1) P51857 1 (2, 1, 0) Aldehyde dehydrogenase X, mitochondrial (ALDH1B1) P30837 3 (0, 2, 0) Aldehyde dehydrogenase...”
- Enhanced Anti-Cancer Effects of Conditioned Medium from Hypoxic Human Adult Dermal Fibroblasts on Cervical Cancer Cells.
Han, International journal of molecular sciences 2022 - “...P61158 ADRA2A 2 2.096 () P08913 ANXA6 2 2.433 () P08133 ALDH3B1 2 2.358 () P43353 COL3A1 2 2.315 (+) P02461 ADGRE1 2 2.042 () Q14246 HMGB1 2 2.070 () P09429 S100A6 2 2.027 () P06703 TFAP2A 2 2.465 () P05549 POU2F2 2 2.073 () P09086...”
- Salivaomics as a Potential Tool for Predicting Alzheimer's Disease During the Early Stages of Neurodegeneration
François, Journal of Alzheimer's disease : JAD 2021 - “...in MCI and AD groups. It is known that the members of this family (P51648, P43353, P30838) catalyze numerous reactions in glycolysis and tyrosine and phenylalanine associated pathways ( Fig.4A ). Energy pathways such as glycolysis, oxidative phosphorylation and citrate cycle are the most crucial metabolic...”
- Identification of potential biomarkers and immune cell infiltration in acute myocardial infarction (AMI) using bioinformatics strategy.
Xie, Bioengineered 2021 - “...0.049184985 0.037474274 I3WAC9, P01308, Q15599 hsa00982 Drug metabolism cytochrome P450 0.049184985 0.037474274 Q5JPC7, Q99518, A0A024R5D8, P43353 hsa04360 Axon guidance 0.049184985 0.037474274 Q8N8S7, P52803, O14786, Q68DN3, Q59F20, Q6AWA9 hsa04520 Adherens junction 0.049184985 0.037474274 O60716, Q6MZU1, Q07157, P28827 hsa00980 Metabolism of xenobiotics by cytochrome P450 0.049184985 0.037474274 Q16678,...”
- “...Tryptophan metabolism 0.049184985 0.037474274 Q16678, Q53TK1, P14902 hsa05204 Chemical carcinogenesis 0.049184985 0.037474274 Q16678, Q53TK1, A0A024R5D8, P43353 Figure 5. Functional enrichment of STEMI-related genes . Top 6 enriched GO terms in biological process (BP), cellular component (CC), and molecular function (MF) were depicted with bar plots (a,...”
- Anti-epileptic drug topiramate upregulates TGFβ1 and SOX9 expression in primary embryonic palatal mesenchyme cells: Implications for teratogenicity.
Rafi, PloS one 2021 - “...class A domain-containing protein 1 LDLRAD1 / LRP1 Q5T700 109 1.64 Aldehyde dehydrogenase 7 ALDH3B1 P43353 92 1.46 NADPH oxidase 5 NOX5 Q96PH1 282 1.46 Proto-oncogene tyrosine-protein kinase receptor Ret RET P07949 490 1.42 Cardiac troponin I TNNI3(cTnl) P19429 146 1.39 Transforming Growth Factor beta 1...”
- Molecular Profiling of Innate Immune Response Mechanisms in Ventilator-associated Pneumonia.
Pathak, Molecular & cellular proteomics : MCP 2020 - “...26.08 0.0080 P30043 Flavin reductase (NADPH) (BLVRB) 26.14 0.0092 P06727 Apolipoprotein A-IV (APOA4) 26.16 0.0129 P43353 Aldehyde dehydrogenase family 3 member B1 (ALDH3B1) 26.22 0.0010 P30041 Peroxiredoxin-6 (PRDX6) 26.31 0.0092 P07988 Pulmonary surfactant-associated protein B (SFTPB) 26.46 0.0330 Q13740 CD166 antigen (ALCAM) 26.52 0.0059 P19338 Nucleolin...”
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- Potential clinical significance of ALDH3B1 in auxiliary diagnosis of gastric cancer.
Tang, Biomarkers in medicine 2024 (PubMed)- GeneRIF: Potential clinical significance of ALDH3B1 in auxiliary diagnosis of gastric cancer.
- [ALDH3B1 expression is correlated with histopathology and long-term prognosis of gastric cancer].
Li, Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2022 - GeneRIF: [ALDH3B1 expression is correlated with histopathology and long-term prognosis of gastric cancer].
- Substrate specificity, plasma membrane localization, and lipid modification of the aldehyde dehydrogenase ALDH3B1.
Kitamura, Biochimica et biophysica acta 2013 (PubMed)- GeneRIF: the likely physiological function of ALDH3B1 is to oxidize lipid-derived aldehydes generated in the plasma membrane and not to be involved in the sphingolipid metabolism in the endoplasmic reticulum.
- New genetic associations detected in a host response study to hepatitis B vaccine.
Davila, Genes and immunity 2010 (PubMed)- GeneRIF: Observational study of gene-disease association. (HuGE Navigator)
- Molecular characterization, expression analysis, and role of ALDH3B1 in the cellular protection against oxidative stress.
Marchitti, Free radical biology & medicine 2010 - GeneRIF: protects cells from the damaging effects of oxidative stress
- Aldehyde dehydrogenase 3B1 (ALDH3B1): immunohistochemical tissue distribution and cellular-specific localization in normal and cancerous human tissues.
Marchitti, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2010 - GeneRIF: The specificity of ALDH3B1 distribution may prove to be directly related to the functional role of this enzyme in human tissues.
- Evidence of epistasis between the catechol-O-methyltransferase and aldehyde dehydrogenase 3B1 genes in paranoid schizophrenia.
Wang, Biological psychiatry 2009 (PubMed)- GeneRIF: These findings provided convincing evidence that epistasis between the catechol-O-methyltransferase and aldehyde dehydrogenase 3B1 genes plays an important role in the pathogenesis of schizophrenia
- GeneRIF: Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
- Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.
Saito, Journal of human genetics 2009 (PubMed)- GeneRIF: Observational study of gene-disease association. (HuGE Navigator)
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G7PP62 Aldehyde dehydrogenase from Macaca fascicularis
40% identity, 90% coverage
AL3A1_HUMAN / P30838 Aldehyde dehydrogenase, dimeric NADP-preferring; ALDHIII; Aldehyde dehydrogenase 3; Aldehyde dehydrogenase family 3 member A1; EC 1.2.1.5 from Homo sapiens (Human) (see 2 papers)
P30838 aldehyde dehydrogenase [NAD(P)+] (EC 1.2.1.5) from Homo sapiens (see 8 papers)
NP_000682 aldehyde dehydrogenase, dimeric NADP-preferring isoform 1 from Homo sapiens
38% identity, 95% coverage
- function: ALDHs play a major role in the detoxification of alcohol- derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (PubMed:1737758). Preferentially oxidizes aromatic aldehyde substrates (PubMed:1737758). Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity).
catalytic activity: an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+) (RHEA:16185)
catalytic activity: octanal + NAD(+) + H2O = octanoate + NADH + 2 H(+) (RHEA:44100)
subunit: Homodimer. - Proteomic Analysis Reveals Cadherin, Actin, and Focal Adhesion Molecule-Mediated Formation of Cervical Cancer Spheroids
Molika, Cells 2024 - “...Q14692 2.247 0.038 9 TOIP1 Q5JTV8 2.144 0.018 10 RL15 P61313 2.087 0.004 11 AL3A1 P30838 2.084 0.014 12 MBB1A Q9BQG0 1.995 0.041 13 CSN3 Q9UNS2 1.994 0.011 14 PRS6B P43686 1.969 0.003 15 ACTB P60709 1.880 0.022 16 MTAP Q13126 1.824 0.029 17 SIAS Q9NR45...”
- Novel approach to exploring protease activity and targets in HIV-associated obstructive lung disease using combined proteomic-peptidomic analysis.
Samorodnitsky, Respiratory research 2024 - “...P04406 65.3887 91.5802 0.0046 0.0414 Myosin-9 P35579 61.5678 88.5792 0.0046 0.0414 Aldehyde dehydrogenase, dimeric NADP-preferring P30838 61.6220 91.1401 0.0046 0.0414 Glutathione S-transferase P P09211 61.7737 91.1076 0.0054 0.0414 Vimentin P08670 78.8246 96.0831 0.0054 0.0414 Isoform A2 of Heterogeneous nuclear ribonucleoproteins A2/B1 P22626-2 66.1016 89.0858 0.0062 0.0425...”
- Characterization of human oxidoreductases involved in aldehyde odorant metabolism.
Boichot, Scientific reports 2023 - “...respectively) Retinal dehydrogenase 1 (ALDH1A1) P00352 59 (299, 212, 73) Aldehyde dehydrogenase, dimeric NADP-preferring (ALDH3A1) P30838 52 (248, 207, 30) Alcohol dehydrogenase class 4 mu/sigma chain (ADH7) P40394 35 (100, 77, 14) Alcohol dehydrogenase 1C (ADH1C or ADH3) P00326 29 (99, 74, 12) Peroxiredoxin-5, mitochondrial P30044...”
- “...production and purification The DNA sequences encoding human ALDH1A1 (UniProt code P00352), ALDH3A1 (UniProt code P30838), and AKR1B10 (UniProt code O60218) were optimized for expression in E. coli, and the sequence GC rate was modified to approximately 50%. They were subcloned into the pET24b, pET22b, and...”
- Systematic review and meta-analysis of mass spectrometry proteomics applied to ocular fluids to assess potential biomarkers of age-related macular degeneration.
Guo, BMC ophthalmology 2023 - “...ELISA Western Blot iTRAQ No/No AMD vs Controls: P05109; Q14118; P01876 P02763;P06727; P07451 ; P02788; P30838; P01042; P63261; P19823; P02647; P19652; P07225; P25311; P43652 P80748; P00338; P01024; P02750; P02760; P02675; P04196; P00734; P00747; P05546; P61626; P04406; P01775; P00751; P10451; P01023; P35749; P02774; P31025; P01861; P01772; Q9HCQ7;...”
- Proteins from toad's parotoid macroglands: do they play a role in gland functioning and chemical defence?
Kowalski, Frontiers in zoology 2023 - “...UV excision repair protein RAD23 homolog B DNA repair, cell response to IL-7 10, 11 P30838 206 50,685 6 5 Aldehyde dehydrogenase, dimeric NADP-preferring Lipid metabolism, xenobiotic metabolism 7 Q9CR51 204 13,808 4 9 V-type proton ATPase subunit G 1 Cell response to increased oxygen levels...”
- Saliva changes in composition associated to COVID-19: a preliminary study
Muñoz-Prieto, Scientific reports 2022 - “...Dunn test for multiple comparison Regulation in COVID-19 mild disease Log2 fold change P -value P30838 Aldehyde dehydrogenase, dimeric NADP-preferring 2 3-chloroallyl aldehyde dehydrogenase activity 0.01* 1.29 0.006** Down Q8N4F0 BPI fold-containing family B member 2 5 Lipid binding 0.003** 1.19 0.01* Down P29508 Serpin B3...”
- Proteomics Analysis of Gastric Cancer Patients with Diabetes Mellitus
Osório, Journal of clinical medicine 2021 - “...Protein S100-P P25815 S100P 1.837 5 Galectin-10 Q05315 CLC 1.771 7 Aldehyde dehydrogenase, dimeric NADP-preferring P30838 ALDH3A1 1.701 21 Caveolae-associated protein 3 E9PIE3 CAVIN3 1.691 8 Gastrokine-2 Q86XP6 GKN2 1.654 6 Eosinophil peroxidase P11678 EPX 1.629 15 Marginal zone B- and B1-cell-specific protein Q8WU39 MZB1 1.586...”
- Proteomic Characterization of Two Extracellular Vesicle Subtypes Isolated from Human Glioblastoma Stem Cell Secretome by Sequential Centrifugal Ultrafiltration
Di, Biomedicines 2021 - “...6.2461.59 0.0010 S153 FKBP4 Q02790 Peptidyl-prolyn cis-trans isomerase 50 29 48 5.3552.05 0.0073 S160 AL3A1 P30838 Aldehyde dehydrogenase, dimeric NADP-preferring 41 11 18 6.1150.76 0.0001 S168 HNRH1 P31943 Heterogeneous nuclear ribonucleo protein H1 119 28 54 5.8949.48 0.0022 S169 FKBP5 Q13451 Peptidyl-prolyn cis-trans isomerase 36 18...”
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- ALDH3A1 overexpression in OSCC inhibits inflammation via phospho-Ser727 at STAT3 in tumor-associated macrophages.
Wang, Oral diseases 2023 (PubMed)- GeneRIF: ALDH3A1 overexpression in OSCC inhibits inflammation via phospho-Ser727 at STAT3 in tumor-associated macrophages.
- Hypoxia-induced ALDH3A1 promotes the proliferation of non-small-cell lung cancer by regulating energy metabolism reprogramming.
Chen, Cell death & disease 2023 - GeneRIF: Hypoxia-induced ALDH3A1 promotes the proliferation of non-small-cell lung cancer by regulating energy metabolism reprogramming.
- Association with Corneal Remodeling Related Genes, ALDH3A1, LOX, and SPARC Genes Variations in Korean Keratoconus Patients.
Mok, Korean journal of ophthalmology : KJO 2021 - GeneRIF: Association with Corneal Remodeling Related Genes, ALDH3A1, LOX, and SPARC Genes Variations in Korean Keratoconus Patients.
- Aldehyde dehydrogenase 3A1 confers oxidative stress resistance accompanied by altered DNA damage response in human corneal epithelial cells.
Voulgaridou, Free radical biology & medicine 2020 (PubMed)- GeneRIF: Aldehyde dehydrogenase 3A1 confers oxidative stress resistance accompanied by altered DNA damage response in human corneal epithelial cells.
- Exosomes carrying ALDOA and ALDH3A1 from irradiated lung cancer cells enhance migration and invasion of recipients by accelerating glycolysis.
Wang, Molecular and cellular biochemistry 2020 (PubMed)- GeneRIF: Exosomes carrying ALDOA and ALDH3A1 from irradiated lung cancer cells enhance migration and invasion of recipients by accelerating glycolysis.
- Aldehyde dehydrogenase isoforms and inflammatory cell populations are differentially expressed in term human placentas affected by intrauterine growth restriction.
Chu, Placenta 2019 - GeneRIF: higher expression in fetal growth restriction-associated placentas but localized specifically to extravillous trophoblasts
- Gastric cancer depends on aldehyde dehydrogenase 3A1 for fatty acid oxidation.
Lee, Scientific reports 2019 - GeneRIF: Gastric cancer depends on aldehyde dehydrogenase 3A1 for fatty acid oxidation.
- Human aldehyde dehydrogenase 3A1 (ALDH3A1) exhibits chaperone-like function.
Voulgaridou, The international journal of biochemistry & cell biology 2017 (PubMed)- GeneRIF: ALDH3A1 appears to play an essential role in protecting cellular proteins against aggregation under stress conditions
- More
WH7805_06416 Putative aldehyde dehydrogenase from Synechococcus sp. WH 7805
39% identity, 85% coverage
- Bioinformatic evaluation of L-arginine catabolic pathways in 24 cyanobacteria and transcriptional analysis of genes encoding enzymes of L-arginine catabolism in the cyanobacterium Synechocystis sp. PCC 6803
Schriek, BMC genomics 2007 - “...8102 SYNW1412, SYNW2422 SYNW1634, SYNW0629 SYNW1956 Synechococcus sp. WH 7805 WH7805_06086, WH7805_09974 WH7805_05656, WH7805_12388, WH7805_13803 WH7805_06416 Synechococcus sp. WH 5701 WH5701_03684, WH5701_03860 WH5701_07406, WH5701_15376 WH5701_06196 Synechococcus sp. RS 9917 RS9917_06190 RS9917_02041, RS9917_05240 RS9917_02641 Crocosphaera watsonii WH 8501 n.d. CwatDRAFT_5161 CwatDRAFT_0865, CwatDRAFT_0842, CwatDRAFT_0969 Trichodesmium erythraeum IMS 101...”
- “...sp. WH 8102 n.d. SYNW1634, SYNW0629 SYNW1956 Synechococcus sp. WH 7805 n.d. WH7805_05656, WH7805_12388, WH7805_13803 WH7805_06416 Synechococcus sp. WH 5701 n.d. WH5701_07406, WH5701_15376 WH5701_06196 Synechococcus sp. RS 9917 n.d. RS9917_02041, RS9917_05240 RS9917_02641 Crocosphaera watsonii WH 8501 CwatDRAFT_0830 CwatDRAFT_5161 CwatDRAFT_0865, CwatDRAFT_0842, CwatDRAFT_0969 Trichodesmium erythraeum IMS 101 TeryDRAFT_2282...”
4l1oB / P30838 Crystal structure of human aldh3a1 with inhibitor 1-{[4-(1,3- benzodioxol-5-ylmethyl)piperazin-1-yl]methyl}-1h-indole-2,3-dione (see paper)
38% identity, 95% coverage
- Ligand: (3s)-1-{[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]methyl}-3-hydroxy-1,3-dihydro-2h-indol-2-one (4l1oB)
F1SDC7 Aldehyde dehydrogenase from Sus scrofa
41% identity, 77% coverage
Awo_c33720 aldehyde dehydrogenase from Acetobacterium woodii DSM 1030
37% identity, 93% coverage
alkH / P12693 aldehyde dehydrogenase (EC 1.2.1.3) from Pseudomonas oleovorans (see 3 papers)
ALDH_PSEOL / P12693 Aldehyde dehydrogenase; EC 1.2.1.3 from Pseudomonas oleovorans (see paper)
alkH / GB|CAB54053.1 aldehyde dehydrogenase from Pseudomonas oleovorans (see paper)
alkH / CAB54053.1 aldehyde dehydrogenase from Pseudomonas putida (see 6 papers)
40% identity, 88% coverage
PMN2A_1709 Putative aldehyde dehydrogenase from Prochlorococcus marinus str. NATL2A
40% identity, 90% coverage
- Heterotroph Interactions Alter Prochlorococcus Transcriptome Dynamics during Extended Periods of Darkness
Biller, mSystems 2018 - “..., murQ , pdhB , pgi , prkB , rpi , tpiA , truB , PMN2A_1709, PMN2A_1584 6.6E02 Generation of precursor metabolites and energy acnB , acoA , glpX , icd , lpd , ndhH , petC , petD , pgi , pdhB , prkB ,...”
- “..., ispG , lytB , pykF , tpiA 4.6E02 Sugar degradation deoC , pgi , PMN2A_1709 3.0E03 Enriched only in axenic cultures Alcohol biosynthesis degradation, glycerol degradation gldA , pykF , tpiA 1.5E02 CO 2 fixation glpX , prkB , rpi , tpiA 1.2E02 Fatty acid...”
- Bioinformatic evaluation of L-arginine catabolic pathways in 24 cyanobacteria and transcriptional analysis of genes encoding enzymes of L-arginine catabolism in the cyanobacterium Synechocystis sp. PCC 6803
Schriek, BMC genomics 2007 - “...n.d PMM0615 n.d PMM1215, PMM0331 Prochlorococcus marinus NATL 2A PMN2A_0665, PMN2A_1378 PMN2A_1287 n.d PMN2A_0052 n.d PMN2A_1709 Synechococcus sp. CC 9605 Syncc9605_1621, Syncc9605_2513 Syncc9605_1082Syncc9605_2591 n.d Syncc9605_1134 n.d Syncc9605_0497 Synechococcus sp. CC 9902 Syncc9902_1380, Syncc9902_2172 Syncc9902_2230 n.d Syncc9902_1323 n.d Syncc9902_1838 Synechococcus sp. WH 8102 SYNW0944, SYNW2359 SYNW1412, SYNW2422...”
- “...Prochlorococcus marinus MED 4 PMM1686 PMM1301, PMM1472 PMM0331 Prochlorococcus marinus NATL 2A PMN2A_1287 PMN2A_0867, PMN2A_1003 PMN2A_1709 Synechococcus sp. CC 9605 Syncc9605_1082, Syncc9605_2591 Syncc9605_0858, Syncc9605_2052, Syncc9605_0659 Syncc9605_0497 Synechococcus sp. CC 9902 Syncc9902_2230 Syncc9902_1534, Syncc9902_0620 Syncc9902_1838 Synechococcus sp. WH 8102 SYNW1412, SYNW2422 SYNW1634, SYNW0629 SYNW1956 Synechococcus sp. WH...”
XP_006532087 aldehyde dehydrogenase, dimeric NADP-preferring isoform X1 from Mus musculus
38% identity, 94% coverage
- Generation and characterization of Aldh3-Cre transgenic mice as a tool for conditional gene deletion in postnatal cornea.
Sunny, Scientific reports 2020 - GeneRIF: Generation and characterization of Aldh3-Cre transgenic mice as a tool for conditional gene deletion in postnatal cornea.
- Mutation of the gene encoding the circadian clock component PERIOD2 in oncogenic cells confers chemoresistance by up-regulating the Aldh3a1 gene.
Katamune, The Journal of biological chemistry 2019 - GeneRIF: This study found that oncogene-transformed embryonic fibroblasts prepared from Per2-mutant (Per2(m/m) ) mice, which are susceptible to both spontaneous and radiation-induced tumorigenesis, were resistant against common chemotherapeutic drugs and that this resistance is associated with up-regulation of the aldehyde dehydrogenase 3a1 (Aldh3a1) gene.
- Metabolic pharmacokinetics of early chronic alcohol consumption mediated by liver alcohol dehydrogenases 1 and 3 in mice.
Okuda, Journal of gastroenterology and hepatology 2018 (PubMed)- GeneRIF: It is responsible for systemic alcohol metabolism.
- Aldehyde dehydrogenase 3A1 activation prevents radiation-induced xerostomia by protecting salivary stem cells from toxic aldehydes.
Saiki, Proceedings of the National Academy of Sciences of the United States of America 2018 - GeneRIF: ALDH3A1 activation by d-limonene significantly reduced aldehyde accumulation in SSPCs.
- The Contribution of Alcohol Dehydrogenase 3 to the Development of Alcoholic Osteoporosis in Mice.
Okuda, Journal of Nippon Medical School = Nippon Ika Daigaku zasshi 2018 (PubMed)- GeneRIF: The alcohol dehydrogenase 3 (ADH3-/-) control mice exhibited increased activities of both osteoblasts and osteoclasts and lower bone masses than the WT control mice.
- Corneal haze phenotype in Aldh3a1-null mice: In vivo confocal microscopy and tissue imaging mass spectrometry.
Chen, Chemico-biological interactions 2017 (PubMed)- GeneRIF: The corneal phenotype of Aldh3a1 showed no differences were observed in lipid profiles from knockout relative to wild type mice; however, changes in protein profiles of acyl-CoA binding protein (m/z 9966) and histone H4.4 (m/z 11308) were found to be increased in the corneal epithelial layer of knockout mice.
- ALDH3A1 Plays a Functional Role in Maintenance of Corneal Epithelial Homeostasis.
Koppaka, PloS one 2016 - GeneRIF: ALDH3A1 has a role in the maintenance of corneal epithelial homeostasis by simultaneously modulating proliferation and differentiation through both enzymatic and non-enzymatic mechanisms
- Pharmacological recruitment of aldehyde dehydrogenase 3A1 (ALDH3A1) to assist ALDH2 in acetaldehyde and ethanol metabolism in vivo.
Chen, Proceedings of the National Academy of Sciences of the United States of America 2015 - GeneRIF: focused on ALDH3A1, which is enriched in the upper aerodigestive track, and identified Alda-89 as a small molecule that enables ALDH3A1 to metabolize acetaldehyde
- More
MAB_4605c Probable aldehyde dehydrogenase from Mycobacterium abscessus ATCC 19977
38% identity, 90% coverage
AL3B2_MOUSE / E9Q3E1 Aldehyde dehydrogenase family 3 member B2; Aldh3B2; Aldehyde dehydrogenase 8; Long-chain fatty aldehyde dehydrogenase; EC 1.2.1.3; EC 1.2.1.48 from Mus musculus (Mouse) (see paper)
E9Q3E1 long-chain-aldehyde dehydrogenase (EC 1.2.1.48) from Mus musculus (see paper)
NP_001170909 aldehyde dehydrogenase family 3 member B2 from Mus musculus
39% identity, 88% coverage
AL3A1_MOUSE / P47739 Aldehyde dehydrogenase, dimeric NADP-preferring; Aldehyde dehydrogenase 4; Aldehyde dehydrogenase family 3 member A1; Dioxin-inducible aldehyde dehydrogenase 3; EC 1.2.1.5 from Mus musculus (Mouse) (see 3 papers)
P47739 aldehyde dehydrogenase [NAD(P)+] (EC 1.2.1.5) from Mus musculus (see paper)
38% identity, 94% coverage
- function: ALDHs play a major role in the detoxification of alcohol- derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (PubMed:25286108). Preferentially oxidizes aromatic aldehyde substrates (PubMed:11784860). Comprises about 50 percent of corneal epithelial soluble proteins (PubMed:11784860). May play a role in preventing corneal damage caused by ultraviolet light (PubMed:10376761).
catalytic activity: an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+) (RHEA:16185)
catalytic activity: octanal + NAD(+) + H2O = octanoate + NADH + 2 H(+) (RHEA:44100)
subunit: Homodimer. - Proteomic Alterations in Retinal Müller Glial Cells Lacking Interleukin-6 Receptor: A Comprehensive Analysis.
Glass, Investigative ophthalmology & visual science 2024 - “...protein 4, mitochondrial 1.51 3.04 2.02 0.033 O88322 Nid2 Nidogen-2 1.34 2.64 1.98 0.022 Downregulated P47739 Aldh3a1 Aldehyde dehydrogenase, dimeric NADP-preferring 21.59 5.29 0.24 0.004 P51910 Apod Apolipoprotein D 5.57 1.58 0.28 0.028 Q07646 Mest Mesoderm-specific transcript protein 6.13 1.81 0.29 0.009 Q80YX1 Tnc Tenascin 11.47...”
- Redox Proteomic Profile of Tirapazamine-Resistant Murine Hepatoma Cells
Nemeikaitė-Čėnienė, International journal of molecular sciences 2023 - “...in RH1-Resistance Cells [ 36 ] 1 2 3 4 5 6 Upregulated 1 Aldh3a1 P47739 Aldehyde dehydrogenase, dimeric NADP-preferring 5.18 2 Aldh1a1 P24549 Retinaldehyde dehydrogenase 1 4.97 6.00 3 Adh7 Q64437 Alcohol dehydrogenase class 4 mu/sigma chain 4.80 1.16 4 Aldh3b1 Q3TX25 Aldehyde dehydrogenase family...”
- The Gut Microbial Metabolite Pyrogallol Is a More Potent Inducer of Nrf2-Associated Gene Expression Than Its Parent Compound Green Tea (-)-Epigallocatechin Gallate.
Liu, Nutrients 2022 - “...B. For instance, the FCs of Aldehyde dehydrogenase family 3, subfamily A1 (Aldh3a1, protein ID: P47739) in PG and t-BHQ treatments were 1.9 ( p < 0.001) and 2.5 ( p < 0.001), respectively, while they were 1.0 (all non-significant) in the other groups. The FCs...”
- miR-29a/b1 Regulates the Luteinizing Hormone Secretion and Affects Mouse Ovulation
Guo, Frontiers in endocrinology 2021 - “...1.32 G3X982 Aox3 Aldehyde oxidase 3 OS=Mus musculus GN=Aox3 PE=1 SV=1 147 kDa 0.0065 1.32 P47739 Aldh3a1 Aldehyde dehydrogenase, dimeric NADP-preferring OS=Mus musculus GN=Aldh3a1 PE=1 SV=2 50 kDa < 0.0001 1.31 Q9D164 Fxyd6 FXYD domain-containing ion transport regulator 6 OS=Mus musculus GN=Fxyd6 PE=1 SV=2 10 kDa...”
- Dataset on the comparative proteomic profiling of mouse saliva and serum from wild type versus the dystrophic mdx-4cv mouse model of dystrophinopathy
Murphy, Data in brief 2018 - “...Sulfhydryl oxidase 1 Qsox1 Q8VIG02 Isoform 2 of Zinc finger CCHC domain-containing protein 14 Zcchc14 P47739 Aldehyde dehydrogenase, dimeric NADP-preferring Aldh3a1 P10107 Annexin A1 Anxa1 E9Q3E1 Aldehyde dehydrogenase family 3 member B2 Aldh3b2 Q9R0M4 Podocalyxin Podxl P09041 Phosphoglycerate kinase 2 Pgk2 Q08189 Protein-glutamine gamma-glutamyltransferase E Tgm3...”
- Differences in the BAL proteome after Klebsiella pneumoniae infection in wild type and SP-A-/- mice.
Ali, Proteome science 2010 - “...dehydrogenase II P24549 RED 7-11 6 Aldehyde dehydrogenase, Dimeric NADP-preferring (EC 1.2.1.5) (ALDH class 3) P47739 RED 4-7 7 Alpha-1-antitrypsin 1-1 precursor (Serine protease inhibitor 1-1) P07758 DEF, PMM 4-7 8 Alpha-1-antitrypsin 1-6 precursor (Serine protease inhibitor 1-6) (Alpha-1 protease inhibitor) P81105 DEF, PMM 4-7 9...”
- “...dehydrogenase II P24549 -25.89 -9.53 6 Aldehyde dehydrogenase, Dimeric NADP-preferring (EC 1.2.1.5) (ALDH class 3) P47739 -4.45 -5.45 7 Alpha-1-antitrypsin 1-1 precursor (Serine protease inhibitor 1-1) P07758 11.73 13.19 8 Alpha-1-antitrypsin 1-6 precursor (Serine protease inhibitor 1-6) (Alpha-1 protease inhibitor) P81105 -1.97 -5.19 9 Alpha-fetoprotein P02772...”
AL3A1_RAT / P11883 Aldehyde dehydrogenase, dimeric NADP-preferring; Aldehyde dehydrogenase family 3 member A1; HTC-ALDH; Tumor-associated aldehyde dehydrogenase; EC 1.2.1.5 from Rattus norvegicus (Rat) (see paper)
NP_114178 aldehyde dehydrogenase, dimeric NADP-preferring from Rattus norvegicus
38% identity, 93% coverage
- function: ALDHs play a major role in the detoxification of alcohol- derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (PubMed:2831537). Preferentially oxidizes aromatic aldehyde substrates (PubMed:2831537). Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity).
catalytic activity: an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+) (RHEA:16185)
catalytic activity: octanal + NAD(+) + H2O = octanoate + NADH + 2 H(+) (RHEA:44100)
subunit: Homodimer - Differential Retinal Protein Expression in Primary and Secondary Retinal Ganglion Cell Degeneration Identified by Integrated SWATH and Target-Based Proteomics
Kwong, International journal of molecular sciences 2021 - “...Uniprot Protein Name FC L/R LogFC p -Value Upregulation M0R9G2 (P06238) Alpha-2-macroglobulin 3.02 1.59 0.00 P11883 Aldehyde dehydrogenase, dimeric NADP-preferring (EC 1.2.1.5) (Aldehyde dehydrogenase family 3 member A1) (HTC-ALDH) (Tumor-associated aldehyde dehydrogenase) 2.61 1.39 0.01 G3V836 Clusterin 2.33 1.22 0.00 P01048 T-kininogen 1 (Alpha-1-MAP) (Major acute...”
- Vitamin A cycle byproducts explain retinal damage and molecular changes thought to initiate retinal degeneration.
Zhang, Biology open 2021 - “...pathway (P02738) protein NDKA; the pentose phosphate pathway (P02762) protein TKT; the 5-hydroxytryptamine degradation pathway (P11883) protein AL3A1; and the pyruvate metabolism pathway (P02772) protein KPYM. Fig. 7. The vitamin A cycle byproduct, A2E, delivered intravitreally dysregulates protein synthesis. (A) Difference gel electrophoresis of proteins isolated...”
- Characterization of rat glutathione transferases in olfactory epithelium and mucus
Heydel, PloS one 2019 - “...the nasal mucus can potentially catalyze the biotransformation of these odorants. Interestingly, 3 aldehyde dehydrogenases (P11883, P13601 and P11884) and 2 alcohol dehydrogenases (P41682 and P51635) were identified. Aldehyde dehydrogenases were previously shown to be involved in the insect odorant metabolism [ 29 ]. Another enzyme,...”
- “...(0) Glutathione S-transferase M2 P08010 12 (15), 3 (3), 1 (1) Aldehyde dehydrogenase, dimeric NADP-preferring P11883 5 (9), 2 (3), 5 (7) Carbonic anhydrase 1 B0BNN3 3 (7), 6 (11), 0 (0) Sulfotransferase 1C1 P50237 8 (10), 2 (3), 0 (0) Peroxiredoxin-5 Q9R063 5 (5), 3...”
- SWATH label-free proteomics analyses revealed the roles of oxidative stress and antioxidant defensing system in sclerotia formation of Polyporus umbellatus.
Li, Scientific reports 2017 - “...phase, indicating its antioxidant activity. It was also note worthy that not all proteins (P08157, P11883, Q9P7K9 etc.) relating to NADPH and GSH generation were increased at the same time, implying the complexity of antioxidant system in cells. Another mechanism cell eliminating ROS is associated with...”
- Inactivation of cytosolic aldehyde dehydrogenase via S-nitrosylation in ethanol-exposed rat liver.
Moon, FEBS letters 2007 - High-throughput identification of IMCD proteins using LC-MS/MS.
Pisitkun, Physiological genomics 2006 - Different doxorubicin formulations affect plasma 4-hydroxy-2-nonenal and gene expression of aldehyde dehydrogenase 3A1 and thioredoxin reductase 2 in rat.
Hlaváčová, Physiological research 2015 (PubMed)- GeneRIF: Different doxorubicin formulations decreased liver expression of ALDH3A1.
- Decreased dopamine D(2) receptor function in cerebral cortex and brain stem: their role in hepatic ALDH regulation in ethanol treated rats.
George, Molecular and cellular biochemistry 2007 (PubMed)- GeneRIF: Decreased function of dopamine mediated through DA D(2) receptor in the cerebral cortex and brain stem enhanced the brain, plasma and liver ALDH activity in ethanol treated rats.
1ad3A / P11883 Class 3 aldehyde dehydrogenase complex with nicotinamide-adenine- dinucleotide (see paper)
38% identity, 95% coverage
- Ligand: nicotinamide-adenine-dinucleotide (1ad3A)
ALDH3A2 / P51648 fatty aldehyde dehydrogenase (EC 1.2.1.3; EC 1.2.1.94; EC 1.2.1.39) from Homo sapiens (see 10 papers)
AL3A2_HUMAN / P51648 Aldehyde dehydrogenase family 3 member A2; Aldehyde dehydrogenase 10; Fatty aldehyde dehydrogenase; Microsomal aldehyde dehydrogenase; EC 1.2.1.3; EC 1.2.1.94 from Homo sapiens (Human) (see 11 papers)
P51648 long-chain-aldehyde dehydrogenase (EC 1.2.1.48) from Homo sapiens (see paper)
40% identity, 86% coverage
- function: Catalyzes the oxidation of medium and long chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length (PubMed:18035827, PubMed:18182499, PubMed:22633490, PubMed:25047030, PubMed:9133646, PubMed:9662422). Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid (PubMed:22633490).
catalytic activity: an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+) (RHEA:16185)
catalytic activity: a fatty aldehyde + NAD(+) + H2O = a fatty acid + NADH + 2 H(+) (RHEA:49832)
catalytic activity: (2E)-hexadecenal + NAD(+) + H2O = (E)-hexadec-2-enoate + NADH + 2 H(+) (RHEA:36135)
catalytic activity: hexadecanoate + NADH + 2 H(+) = hexadecanal + NAD(+) + H2O (RHEA:33739)
catalytic activity: 22-oxodocosanoate + NAD(+) + H2O = docosanedioate + NADH + 2 H(+) (RHEA:39015)
catalytic activity: 2,6,10,14-tetramethylpentadecanal + NAD(+) + H2O = 2,6,10,14- tetramethylpentadecanoate + NADH + 2 H(+) (RHEA:44016)
catalytic activity: octadecanal + NAD(+) + H2O = octadecanoate + NADH + 2 H(+) (RHEA:44020)
catalytic activity: dodecanoate + NADH + 2 H(+) = dodecanal + NAD(+) + H2O (RHEA:44168)
catalytic activity: decanal + NAD(+) + H2O = decanoate + NADH + 2 H(+) (RHEA:44104)
catalytic activity: tetradecanal + NAD(+) + H2O = tetradecanoate + NADH + 2 H(+) (RHEA:44172)
catalytic activity: octanal + NAD(+) + H2O = octanoate + NADH + 2 H(+) (RHEA:44100)
catalytic activity: heptanal + NAD(+) + H2O = heptanoate + NADH + 2 H(+) (RHEA:44108)
catalytic activity: (2E,6E)-farnesal + NAD(+) + H2O = (2E,6E)-farnesoate + NADH + 2 H(+) (RHEA:24216)
subunit: Homodimer. - Molecular characterization of extracellular vesicles derived from follicular fluid of women with and without PCOS: integrating analysis of differential miRNAs and proteins reveals vital molecules involving in PCOS
Yang, Journal of assisted reproduction and genetics 2023 - “...Q15392 DHC24 Delta(24)-sterol reductase 0.607 0.96 0.004 Q13530 SERC3 Serine incorporator 3 0.606 0.96 0.014 P51648 AL3A2 Fatty aldehyde dehydrogenase 0.604 0.96 0.007 P21964 COMT Catechol O-methyltransferase 0.595 0.96 0.026 A0M8Q6 IGLC7 Immunoglobulin lambda constant 7 0.594 0.97 0.028 Q14764 MVP Major vault protein 0.587 0.96...”
- Bi-allelic variants of FILIP1 cause congenital myopathy, dysmorphism and neurological defects.
Roos, Brain : a journal of neurology 2023 - Ellagic Acid Triggers the Necrosis of Differentiated Human Enterocytes Exposed to 3-Nitro-Tyrosine: An MS-Based Proteomic Study
Díaz-Velasco, Antioxidants (Basel, Switzerland) 2022 - “...dehydrogenase ALDH3A2 2.96 10 5 2.08 Catalyzes the oxidation of aliphatic aldehydes to fatty acids P51648 Thioredoxin domain-containing protein 17 TXNDC17 3.91 10 6 2.19 Disulfide reductase with peroxidase activity Q9BRA2 Glycine dehydrogenase (decarboxylating), mitochondrial GLDC 2.17 10 5 2.23 Catalyzes the degradation of glycine P23378...”
- Salivaomics as a Potential Tool for Predicting Alzheimer's Disease During the Early Stages of Neurodegeneration
François, Journal of Alzheimer's disease : JAD 2021 - “...AD group compared with controls, which was associated with lower aldehyde dehydrogenase 3 (Uniprot ID P51648) (Log2FC=2.08) with respect to MCI (Log2FC=1.32). In tyrosine and phenylalanine metabolism, both tyrosine and phenylalanine accumulation were observed in the AD group but not in the control group. Significant accumulation...”
- “...activities in MCI and AD groups. It is known that the members of this family (P51648, P43353, P30838) catalyze numerous reactions in glycolysis and tyrosine and phenylalanine associated pathways ( Fig.4A ). Energy pathways such as glycolysis, oxidative phosphorylation and citrate cycle are the most crucial...”
- Interactome Analysis of the ER Stress Sensor Perk Uncovers Key Components of ER-Mitochondria Contact Sites and Ca2+ Signalling
Sassano, Contact (Thousand Oaks (Ventura County, Calif.)) 2021 - “...4 4 0 0 100% 0 Fatty aldehyde dehydrogenase OS=Homo sapiens OX=9606 GN=ALDH3A2 PE=1 SV=1 P51648 ALDH3A2 55 kDa 4 4 0 0 100% 0 Creatine kinase B-type OS=Homo sapiens OX=9606 GN=CKB PE=1 SV=1 P12277 CKB 43 kDa 4 4 0 0 100% 0 Syntaxin-5 OS=Homo...”
- Proteomic Analysis of Aqueous Humor Proteins in Association with Cataract Risks: Diabetes and Smoking.
Chang, Journal of clinical medicine 2021 - “...coli protein 2 P0DOX8 Immunoglobulin lambda-1 light chain P02768 Albumin B9A064 Immunoglobulin lambda-like polypeptide 5 P51648 Aldehyde dehydrogenase family 3 member A2 P24592 Insulin-like growth factor-binding protein 6 P02763 Alpha-1-acid glycoprotein 1 Q16270 Insulin-like growth factor-binding protein 7 P19652 Alpha-1-acid glycoprotein 2 Q14624 Inter-alpha-trypsin inhibitor heavy...”
- Highlighting Human Enzymes Active in Different Metabolic Pathways and Diseases: The Case Study of EC 1.2.3.1 and EC 2.3.1.9
Babbi, Biomedicines 2020 - “...(0) 1.2.1.47 (1) P05091 (12) -hsa00260 1O02 (homo 4-mer) 45 75 88/223; 16/41 (19/133; 4/25) P51648 (12) -hsa00260 4QGK (homo 2-mer) 91 107 82/238; 19/54 (20/139; 4/32) 1.2.1.94 (0) P30837 (12)-hsa00260 - 41 93 111/517; 1/1 2.3.1.9 13: hsa00071 hsa00072 hsa00280 hsa00310 hsa00380 hsa00620 hsa00630 hsa00640...”
- High-throughput, Label-Free Quantitative Proteomic Studies of the Anticancer Effects of Electrical Pulses with Turmeric Silver Nanoparticles: an in vitro Model Study
Mittal, Scientific reports 2020 - “...P05091 Aldehyde dehydrogenase, mitochondrial ALDH2 0.89 # 3.1E-04* 0.71 # 3.7E-03* 0.83 # 3.7E-03* 4 P51648 Aldehyde dehydrogenase family 3 member A2 ALDH3A2 4.93 # 2.4E-07* 4.93 # 2.4E-07* 0.97 # 9.7E-04* 5 P49189 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 5.28 # 3.5E-07* 5.28 # 3.5E-07* 0.36 1.3E-02* 6...”
- More
Q3UNF5 aldehyde dehydrogenase (NAD+) (EC 1.2.1.3) from Mus musculus (see paper)
37% identity, 94% coverage
B7ZN13 Aldehyde dehydrogenase from Mus musculus
37% identity, 94% coverage
AL3B3_MOUSE / J3QMK6 Aldehyde dehydrogenase family 3 member B3; EC 1.2.1.3 from Mus musculus (Mouse) (see paper)
J3QMK6 long-chain-aldehyde dehydrogenase (EC 1.2.1.48) from Mus musculus (see paper)
38% identity, 87% coverage
Q6PKA6 Aldehyde dehydrogenase, dimeric NADP-preferring (Fragment) from Homo sapiens
39% identity, 80% coverage
NM219_06200, NM220_06200 aldehyde dehydrogenase from Parvimonas micra
37% identity, 94% coverage
- Parvimonas micra can translocate from the subgingival sulcus of the human oral cavity to colorectal adenocarcinoma
Conde-Pérez, Molecular oncology 2024 - “...2193 24 NM219_06210 NM220_06210 MBL fold metallohydrolase* 810 24 NM219_06205 NM220_06205 Aldehyde dehydrogenase* 1362 24 NM219_06200 NM220_06200 Hypothetical protein 324 25 NM219_00070 NM220_00070 IS200/IS605 family transposase 459 25 NM219_00075 NM220_00075 Hypothetical protein 1104 25 NM219_00080 NM220_00080 DUF1307 domaincontaining protein 486 26 NM219_00915 NM220_00915 DUF1307 domaincontaining protein...”
- “...24 NM219_06210 NM220_06210 MBL fold metallohydrolase* 810 24 NM219_06205 NM220_06205 Aldehyde dehydrogenase* 1362 24 NM219_06200 NM220_06200 Hypothetical protein 324 25 NM219_00070 NM220_00070 IS200/IS605 family transposase 459 25 NM219_00075 NM220_00075 Hypothetical protein 1104 25 NM219_00080 NM220_00080 DUF1307 domaincontaining protein 486 26 NM219_00915 NM220_00915 DUF1307 domaincontaining protein 477...”
Q60HH8 Aldehyde dehydrogenase family 3 member A2 from Macaca fascicularis
39% identity, 86% coverage
M3W3M4 Aldehyde dehydrogenase from Felis catus
37% identity, 90% coverage
AL3B1_MOUSE / Q80VQ0 Aldehyde dehydrogenase family 3 member B1; Aldehyde dehydrogenase 7; Long-chain fatty aldehyde dehydrogenase; Medium-chain fatty aldehyde dehydrogenase; EC 1.2.1.28; EC 1.2.1.5; EC 1.2.1.7; EC 1.2.1.48 from Mus musculus (Mouse) (see 2 papers)
Q80VQ0 aldehyde dehydrogenase [NAD(P)+] (EC 1.2.1.5) from Mus musculus (see paper)
Q3TX25 Aldehyde dehydrogenase from Mus musculus
37% identity, 90% coverage
- function: Oxidizes medium and long chain saturated and unsaturated fatty aldehydes generated in the plasma membrane into non-toxic fatty acids (PubMed:17382292, PubMed:25286108). May have a protective role against the cytotoxicity induced by lipid peroxidation. Short-chain fatty aldehydes are not good substrates. Can use both NADP(+) and NAD(+) as electron acceptor in vitro, however in vivo preference will depend on their tissue levels. Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde. Able to metabolize aromatic aldehydes such as benzaldehyde to their acid form (By similarity).
catalytic activity: an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+) (RHEA:16185)
catalytic activity: a long-chain fatty aldehyde + NAD(+) + H2O = a long-chain fatty acid + NADH + 2 H(+) (RHEA:10652)
catalytic activity: a medium-chain fatty aldehyde + NAD(+) + H2O = a medium-chain fatty acid + NADH + 2 H(+) (RHEA:69763)
catalytic activity: octanal + NAD(+) + H2O = octanoate + NADH + 2 H(+) (RHEA:44100)
catalytic activity: nonanal + NAD(+) + H2O = nonanoate + NADH + 2 H(+) (RHEA:69759)
catalytic activity: hexadecanoate + NADH + 2 H(+) = hexadecanal + NAD(+) + H2O (RHEA:33739)
catalytic activity: (2E)-octenal + NAD(+) + H2O = (2E)-octenoate + NADH + 2 H(+) (RHEA:59920)
catalytic activity: (E)-non-2-enal + NAD(+) + H2O = (E)-non-2-enoate + NADH + 2 H(+) (RHEA:69767)
catalytic activity: (E)-4-hydroxynon-2-enal + NAD(+) + H2O = (E)-4-hydroxynon-2- enoate + NADH + 2 H(+) (RHEA:67248)
catalytic activity: (2E)-hexadecenal + NAD(+) + H2O = (E)-hexadec-2-enoate + NADH + 2 H(+) (RHEA:36135)
catalytic activity: benzaldehyde + NAD(+) + H2O = benzoate + NADH + 2 H(+) (RHEA:11840)
catalytic activity: an aldehyde + NADP(+) + H2O = a carboxylate + NADPH + 2 H(+) (RHEA:11888)
catalytic activity: a medium-chain fatty aldehyde + NADP(+) + H2O = a medium-chain fatty acid + NADPH + 2 H(+) (RHEA:80815)
catalytic activity: hexanal + NADP(+) + H2O = hexanoate + NADPH + 2 H(+) (RHEA:59908)
catalytic activity: octanal + NADP(+) + H2O = octanoate + NADPH + 2 H(+) (RHEA:59904)
catalytic activity: nonanal + NADP(+) + H2O = nonanoate + NADPH + 2 H(+) (RHEA:80819)
catalytic activity: (2E)-octenal + NADP(+) + H2O = (2E)-octenoate + NADPH + 2 H(+) (RHEA:59916)
catalytic activity: (E)-non-2-enal + NADP(+) + H2O = (E)-non-2-enoate + NADPH + 2 H(+) (RHEA:60692)
catalytic activity: (E)-4-hydroxynon-2-enal + NADP(+) + H2O = (E)-4-hydroxynon-2- enoate + NADPH + 2 H(+) (RHEA:59912)
catalytic activity: benzaldehyde + NADP(+) + H2O = benzoate + NADPH + 2 H(+) (RHEA:21660) - Redox Proteomic Profile of Tirapazamine-Resistant Murine Hepatoma Cells
Nemeikaitė-Čėnienė, International journal of molecular sciences 2023 - “...4.97 6.00 3 Adh7 Q64437 Alcohol dehydrogenase class 4 mu/sigma chain 4.80 1.16 4 Aldh3b1 Q3TX25 Aldehyde dehydrogenase family 3 member B1 3.43 5 Aldh1a7 B2RTL5 Aldehyde dehydrogenase family 1 3.42 5.16 6 Gsto1 O09131 Glutathione S-transferase omega-1 2.63 0.90 7 Cbr3 Q8K354 Carbonyl reductase (NADPH)...”
- “...Resistant Cells [ 36 ] 1 Aldh1a1 P24549 Retinaldehyde dehydrogenase 1 4.97 6.00 2 Aldh3b1 Q3TX25 Aldehyde dehydrogenase family 3 member B1 3.43 3 Gclc P97494 Glutamate-cysteine ligase catalytic subunit 3.40 4 Apoe P08226 Apolipoprotein E OS = Mus musculus 2.17 5 Cat P24270 Catalase 2.00...”
- The impact of abstinence from chronic alcohol consumption on the mouse striatal proteome: sex and subregion-specific differences
Duffus, Frontiers in pharmacology 2024 - “...1 0.0026 P28184 Metallothionein-3 0.0401 P56388 Cocaine- and amphetamine-regulated transcript protein 0.0147 P54227 Stathmin 0.0152 Q80VQ0 Aldehyde dehydrogenase family 3 member B1 0.0089 Q9DBR7 Protein phosphatase 1 regulatory subunit 12A 0.0439 D6REG4 Glyoxylate reductase/hydroxypyruvate reductase 0.0194 P61148 Fibroblast growth factor 1 0.0138 Q9CRD4 Dysbindin domain-containing protein...”
- Orally administered sodium nitrite prevents the increased α-1 adrenergic vasoconstriction induced by hypertension and promotes the S-nitrosylation of calcium/calmodulin-dependent protein kinase II.
Oliveira-Paula, Biochemical pharmacology 2023 - “...10 3 24.21 Q9WTK5 Nuclear factor NF-kappa-B p100 subunit Nfkb2 3.16 6.1 10 3 23.19 Q80VQ0 Aldehyde dehydrogenase family 3 member B1 Aldh3b1 3.29 9.8 10 3 21.90 Q9QX15 Calcium-activated chloride channel regulator 3A-1 Clca3a1 2.56 3.8 10 3 20.52 Q9CRB2 H/ACA ribonucleoprotein complex subunit 2...”
- Tandem mass tag-based quantitative proteomic analysis of effects of multiple sevoflurane exposures on the cerebral cortex of neonatal and adult mice.
Feng, Frontiers in neurology 2022 - Stat3-mediated alterations in lysosomal membrane protein composition.
Lloyd-Lewis, The Journal of biological chemistry 2018 - “...Mgst1 Microsomal glutathione S -transferase 1 Q8BU30 Iars IsoleucinetRNA ligase, cytoplasmic O70309 Itgb5 Integrin -5 Q80VQ0 Aldh3b1 Aldehyde dehydrogenase family 3 member B1 P35821 Ptpn1 Tyrosine-protein phosphatase non-receptor type 1 O70133 Dhx9 ATP-dependent RNA helicase A Q9DBG3 Ap2b1 AP-2 complex subunit P14901 Hmox1 Heme oxygenase 1...”
- Subproteomic profiling of sarcolemma from dystrophic mdx-4cv skeletal muscle.
Murphy, Data in brief 2018 - “...59.5 3.19E-04 6.3 P14869 Rplp0 60S acidic ribosomal protein P0 1 1 56.5 2.55E-04 6.3 Q80VQ0 Aldh3b1 Aldehyde dehydrogenase family 3 member B1 1 1 63.4 3.55E-06 6.0 P14429 H2-Q7 H-2 class I histocompatibility antigen, Q7 alpha chain 1 1 53.0 1.09E-03 6.0 Q8K396 Mnd1 Meiotic...”
- Label-Free Neuroproteomics of the Hippocampal-Accumbal Circuit Reveals Deficits in Neurotransmitter and Neuropeptide Signaling in Mice Lacking Ethanol-Sensitive Adenosine Transporter.
Oliveros, Journal of proteome research 2017 - “...10 2 Q3TYJ1 SLC18A3 solute carrier family 18 - A3 5-HT-R-signaling 2.01 2.7 10 5 Q80VQ0 ALDH3B1 aldehyde dehydrogenase 3 - B1 DA, Trp degradation 1.48 1.6 10 2 Q8BW75 MAOB monoamine oxidase B 5-HT-R-signaling, DA, Trp degradation 1.63 7.1 10 3 Q64133 MAOA monoamine oxidase...”
- Analysis of the membrane proteome of ciprofloxacin-resistant macrophages by stable isotope labeling with amino acids in cell culture (SILAC).
Caceres, PloS one 2013 - “...1.8 ni. 18 P70290 55 kDa erythrocyte membrane protein (p55) 1.12 0.005 10.1 1.02(0.06) 19 Q80VQ0 Aldehyde dehydrogenase 3B1 1.11 0.005 22.6 0.92(0.09) 20 Q7TPR4 Alpha-actinin-1 1.06 0.008 26.9 0.72(0.21) * 21 P17439 Glucosylceramidase precursor 1.05 0.008 15.1 0.19(0.73) 22 Q9CPN8 Insulin-like growth factor 2 mRNA-binding...”
XP_008297392 aldehyde dehydrogenase, dimeric NADP-preferring-like from Stegastes partitus
38% identity, 82% coverage
CRTNC_CYTFI / P0DPF0 4,4'-diapolycopene-4,4'-dial dehydrogenase; 4,4'-diapolycopene aldehyde oxidase; 4,4'-diapolycopene-4,4'-dial oxidase; 4,4'-diapolycopene-4,4'-dioate synthase; EC 1.2.99.10 from Cytobacillus firmus (Bacillus firmus) (see 2 papers)
P0DPF0 4,4'-diapolycopenoate synthase (EC 1.2.99.10) from Cytobacillus firmus (see paper)
38% identity, 93% coverage
- function: Involved in the biosynthesis of the major C30 carotenoid 4,4'-diapolycopene-4,4'-dioic acid, which protects B.firmus from peroxidative reactions (PubMed:22738026). Catalyzes the oxidation of 4,4'-diapolycopene-4,4'-dial to yield 4,4'-diapolycopene-4,4'-dioic aci (PubMed:25326460).
catalytic activity: all-trans-4,4'-diapolycopene-4,4'-dial + 2 A + 2 H2O = all- trans-4,4'-diapolycopene-4,4'-dioate + 2 AH2 + 2 H(+) (RHEA:42380)
Q53NG8 aldehyde dehydrogenase [NAD(P)+] (EC 1.2.1.5) from Oryza sativa (see paper)
40% identity, 87% coverage
I1QYB5 Aldehyde dehydrogenase from Oryza glaberrima
40% identity, 87% coverage
- Unraveling Massive Crocins Transport and Accumulation through Proteome and Microscopy Tools during the Development of Saffron Stigma.
Gómez-Gómez, International journal of molecular sciences 2017 - “...ADHComp3898 (accession number KU577905) (A0A061E1Z5, A0A0B2PSM8, Q8RVW2 and W9RMTS), ADHComp54788 (accession number KU577904) (A0A059BY89 and I1QYB5), ADHComp20158 (accession number KU577906) (K9N4H5) and ADHComp2946 (accession number KU577903) (A0A072TS23 and Q9LRI6), were identified. Phylogenetic analyses revealed that one ADH ( ADHComp54788 ) was closely related to carD ,...”
- “...34.1 6.4 91 1 3 9 A0A059BY89 Aldehyde dehydrogenase 13.2 7.7 85 3 3 4 I1QYB5 Aldehyde dehydrogenase 4.2 2.3 4 1 1 1 Q8VXP2 -Carotene hydroxylase 2.5 4.9 1 1 1 1 A0A075W695 Carotenoid cleavage dioxygenase 2 72.6 23.7 1 4 12 18 B7SNW1 Carotenoid...”
Pro0374 NAD-dependent aldehyde dehydrogenase from Prochlorococcus marinus str. SS120
37% identity, 90% coverage
Q5XI42 Aldehyde dehydrogenase family 3 member B1 from Rattus norvegicus
37% identity, 90% coverage
LOC100232483 LOW QUALITY PROTEIN: aldehyde dehydrogenase family 3 member B1 from Taeniopygia guttata
38% identity, 77% coverage
- Update on the aldehyde dehydrogenase gene (ALDH) superfamily
Jackson, Human genomics 2011 - “...gene ALDH3B1 508879 LOC508879 29 NC_007330.4 47,568,715 47,575,449 yes New gene ALDH3B4 Zebra finch 100232483 LOC100232483 5 NC_011469.1 7,960,933 7,967,624 yes Parent gene ALDH3B1 100229547 LOC100229547 5 NC_011469.1 7,968,165 7,973,465 yes New gene ALDH3B5 ALDH3B2 Rat 688800 ALDH3B2 1 NC_005100.2 206,549,529 206,553,424 yes Parent gene ALDH3B2...”
SYNW1956 putative aldehyde dehydrogenase from Synechococcus sp. WH 8102
42% identity, 90% coverage
- Computational prediction of the osmoregulation network in Synechococcus sp. WH8102
Mao, BMC genomics 2010 - “...PCC6803 b2741 38 SYNW1621 1 E. coli sll0306 RpoD SYNW0102 SYNW0101-0102 1 PCC6803 b0312 BetB SYNW1956 0.99 E. coli b0314 BetT SYNW0229 SYNW0229-0233 0.99 E. coli b4111 ProP SYNW2494 SYNW2494-2495 E. coli b2677 ProV SYNW1915 SYNW1915-1917 0.56 E. coli b2678 ProW SYNW1916 SYNW1915-1917 0.99 E. coli...”
- “...available; GsmT (SYNW1914) and SdmT (SYNW1913) are responsible for synthesizing betaine from glycine; and BetB (SYNW1956) are likely used to synthesize betaine from proline. In addition to the major osmolyte, SpsA (SYNW2520) and SpeA (SYNW2359) are two key enzymes in the sucrose synthesis pathway and arginine...”
- Bioinformatic evaluation of L-arginine catabolic pathways in 24 cyanobacteria and transcriptional analysis of genes encoding enzymes of L-arginine catabolism in the cyanobacterium Synechocystis sp. PCC 6803
Schriek, BMC genomics 2007 - “...sp. CC 9902 Syncc9902_2230 Syncc9902_1534, Syncc9902_0620 Syncc9902_1838 Synechococcus sp. WH 8102 SYNW1412, SYNW2422 SYNW1634, SYNW0629 SYNW1956 Synechococcus sp. WH 7805 WH7805_06086, WH7805_09974 WH7805_05656, WH7805_12388, WH7805_13803 WH7805_06416 Synechococcus sp. WH 5701 WH5701_03684, WH5701_03860 WH5701_07406, WH5701_15376 WH5701_06196 Synechococcus sp. RS 9917 RS9917_06190 RS9917_02041, RS9917_05240 RS9917_02641 Crocosphaera watsonii WH...”
- “...Synechococcus sp. CC 9902 n.d. Syncc9902_1534, Syncc9902_0620 Syncc9902_1838 Synechococcus sp. WH 8102 n.d. SYNW1634, SYNW0629 SYNW1956 Synechococcus sp. WH 7805 n.d. WH7805_05656, WH7805_12388, WH7805_13803 WH7805_06416 Synechococcus sp. WH 5701 n.d. WH5701_07406, WH5701_15376 WH5701_06196 Synechococcus sp. RS 9917 n.d. RS9917_02041, RS9917_05240 RS9917_02641 Crocosphaera watsonii WH 8501 CwatDRAFT_0830...”
ALDH3_BACSU / P46329 Putative aldehyde dehydrogenase AldX; EC 1.2.1.3 from Bacillus subtilis (strain 168) (see paper)
39% identity, 94% coverage
- catalytic activity: an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+) (RHEA:16185)
disruption phenotype: No effect on vanillin degradation.
R0JMW7 Aldehyde dehydrogenase family 3 member A2 (Fragment) from Anas platyrhynchos
37% identity, 91% coverage
Cthe_2238 aldehyde dehydrogenase from Clostridium thermocellum ATCC 27405
37% identity, 92% coverage
- Transcriptomic analysis of Clostridium thermocellum Populus hydrolysate-tolerant mutant strain shows increased cellular efficiency in response to Populus hydrolysate compared to the wild type strain
Linville, BMC microbiology 2014 - “...1.02 1.06 Cthe_1029 phosphate acetyltransferase 1.54 1.79 4.01 3.83 2.42 1.33 2.73 1.63 1.08 1.61 Cthe_2238 Aldehyde Dehydrogenase 1.06 1.04 1.81 1.29 1.20 1.36 1.36 1.02 2.30 1.83 Cthe_0101 iron-containing alcohol dehydrogenase 1.35 1.19 2.19 1.20 1.22 1.04 1.18 1.82 2.43 1.48 Cthe_0423 iron-containing alcohol dehydrogenase...”
- Clostridium thermocellum transcriptomic profiles after exposure to furfural or heat stress
Wilson, Biotechnology for biofuels 2013 - “...S1). Acetyl-CoA can be converted to acetylaldehyde by the action of aldehyde dehydrogenase encoded by Cthe_2238 [ 20 , 24 ] or the activity of a bifunctional alcohol/aldehyde dehydrogenase (Cthe_0423) [ 10 ]. The former gene was not differentially regulated after heat shock or furfural shock;...”
- Proteomic analysis of Clostridium thermocellum core metabolism: relative protein expression profiles and growth phase-dependent changes in protein expression
Rydzak, BMC microbiology 2012 - “...using a bi-functional acetaldehyde/alcohol dehydrogenase (Cthe_0423; adhE ), or indirectly via an NADH-dependant aldehyde dehydrogenase (Cthe_2238; aldH ) and a number of iron containing alcohol dehydrogenases (Cthe_0101, Cthe_0394, Cthe_2579; adh ). Expression of Cthe_2238 ( aldH ), Cthe_0394 ( adhY ), and Cthe_2579 ( adhZ )...”
- Linking genome content to biofuel production yields: a meta-analysis of major catabolic pathways among select H2 and ethanol-producing bacteria
Carere, BMC microbiology 2012 - “...Cphy_1421 Cphy_1416 Cphy_2463 Cphy_1428 Cphy_2463 Cphy_2418 Cphy_2642 Cphy_3041 C. thermocellum ATCC 27405 Cthe_1029 Cthe_1028 Cthe_0551 Cthe_2238 Cthe_0101 Cthe_0423 Cthe_0394 Cthe_2579 C. thermocellum DSM 4150 CtherDRAFT_2741 CtherDRAFT_2742 CtherDRAFT_2349 CtherDRAFT_1042 CtherDRAFT_0189 CtherDRAFT_1096 CtherDRAFT_0616 CtherDRAFT_2833 Ta. pseudethanolicus 39E Teth39_1296 Teth39_1295 Teth39_0220 Teth39_0206 Teth39_1597 Teth39_1979 G. thermoglucosidasius C56-YS93 Cthe_3862 Geoth_0875...”
CtherDRAFT_1042 Aldehyde Dehydrogenase_ from Clostridium thermocellum DSM 4150
37% identity, 92% coverage
E9QH31 Aldehyde dehydrogenase from Danio rerio
37% identity, 85% coverage
- Insights Into the Peroxisomal Protein Inventory of Zebrafish
Kamoshita, Frontiers in physiology 2022 - “...protein 1 with a potential role in dislocation/quality control of tail-anchored membrane proteins; Aldh3a2 (A0A2R8PW97, E9QH31), fatty aldehyde dehydrogenase; Far1/2 (A0A0R4ICF6/Q1L8Q4), fatty acyl-CoA reductase 1/2 (ether lipid biosynthesis); Mavs (F1REK4), mitochondrial antiviral signalling protein with a putative role in innate immune response; Trim37 (E7FBZ8), tripartite motif-containing...”
GRMZM2G060800 aldehyde dehydrogenase, dimeric NADP-preferring from Zea mays
38% identity, 87% coverage
LOC108996365 aldehyde dehydrogenase family 3 member H1-like from Juglans regia
37% identity, 78% coverage
- Integrated Transcriptomic and Proteomic Analysis of Nutritional Quality-Related Molecular Mechanisms in "Longjia", "Yangpao", and "Niangqing" Walnuts (<i>Juglans sigillata</i>)
Wang, International journal of molecular sciences 2024 - “...in the interaction network included XP_018810825.1, XP_018817132.1, XP_018822248.1, XP_018829218.1, XP_018835765.1, XP_018837796.2, XP_018845711.2, XP_035547799.1, LOC108981044, and LOC108996365 ( Figure 7 E,F). Furthermore, the interaction network diagram demonstrates a high degree of correlation among these proteins, suggesting the existence of a complex protein interaction network. These key nodes...”
- “...acetyltransferase NAGS1), XP_018837796.2 (argininosuccinate lyase), XP_018845711.2 (acetylglutamate kinase), XP_035547799.1 (arginase 1), LOC108981044 (malate dehydrogenase), and LOC108996365 (aldehyde dehydrogenase family 3 member H1-like). XP_018810825.1 (glutamate dehydrogenase 1), a pivotal player in glutamate metabolism, has been recognized as a primary ammonium assimilatory enzyme and potentially involved in nitrogen...”
SO3683 coniferyl aldehyde dehydrogenase from Shewanella oneidensis MR-1
36% identity, 89% coverage
V529_39560 aldehyde dehydrogenase family protein from Bacillus velezensis SQR9
38% identity, 98% coverage
- Auxin production and plant growth promotion by Microbacterium albopurpureum sp. nov. from the rhizoplane of leafless Chiloschista parishii Seidenf. orchid
Tsavkelova, Frontiers in plant science 2024 - “...Pyricularia oryzae 70-15 32%, 30% Indole-3-pyruvate decarboxylase WJL96591.1 P9WG37, Mycobacterium tuberculosis 56% Indole-3-acetaldehyde dehydrogenase WJL97005.1 V529_39560, Bacillus velezensis SQR9 33% Tryptamine Tryptophan decarboxylase No hits A7B1V0, Ruminococcus gnavus J7SZ64, Clostridium sporogenes Amine oxidase No hits P80695, Klebsiella oxytoca P46883, Escherichia coli YUCCA Pathway Flavin monooxygenase No...”
- Analysis and cloning of the synthetic pathway of the phytohormone indole-3-acetic acid in the plant-beneficial Bacillus amyloliquefaciens SQR9
Shao, Microbial cell factories 2015 - “...Indolepyruvate decarboxylase ydaP (V529_04190), pycA (V529_14260), padC (V529_34370), yclB (V529_03390), yclC (V529_03400) IAAld dehydrogenase aldX (V529_39560), dhaS (V529_19360), yfmT (V529_06950), ywdH (V529_29500) IAM Trp mono-oxygenase Not detected IAM hydrolase Not detected TAM Trp decarboxylase ydaP (V529_04190), pycA (V529_14260), padC (V529_34370), yclB (V529_03390), yclC (V529_03400) Amine oxidase...”
Saro_1197 aldehyde dehydrogenase from Novosphingobium aromaticivorans DSM 12444
37% identity, 95% coverage
- Catabolism of β-5 linked aromatics by Novosphingobium aromaticivorans
Metz, mBio 2024 - “...(FdhA, Saro_0995, Saro_3899) against a control. Graph B compares the activity of various ALDHs (Saro_1104, Saro_1197, Saro_2869, FerD) against a control. Using the same approach, we found that the cell extracts containing recombinant versions of the putative ALDHs FerD, Saro_1104, Saro_1197, and Saro_2869 can convert DC-L...”
- “...of DC-A, producing the aldehyde DC-L. We also identified four pyridine nucleotide-dependent ALDHs (FerD, Saro_1104, Saro_1197, and Saro_2869) that can oxidize the aldehyde side chain of DC-L to generate the carboxylic acid DC-C. These findings are consistent with RNA-Seq and RB-TnSeq data that indicate increased transcript...”
XP_001655923 aldehyde dehydrogenase, dimeric NADP-preferring isoform X12 from Aedes aegypti
36% identity, 84% coverage
RCF35_04555 aldehyde dehydrogenase family protein from Bacillus velezensis
38% identity, 98% coverage
- Whole genome sequencing data of the submerged macrophytes growth promoting and aerobic denitrifying bacterium Bacillus velezensis NBNZ-0060
Chen, Data in brief 2024 - “...indole-3-pyruvate decarboxylase RCF35_07465, RCF35_12695 ( pyc ), RCF35_01945, RCF35_07080, RCF35_07085 ( bsdC ) indole-3-acetaldehyde dehydrogenase RCF35_04555, RCF35_14870, RCF35_08890, RCF35_18825 tryptamine pathway tryptophan decarboxylase RCF35_07465, RCF35_12695 ( pyc ), RCF35_01945, RCF35_07080, RCF35_07085 ( bsdC ) indole-3-acetaldehyde dehydrogenase RCF35_04555, RCF35_14870, RCF35_08890, RCF35_18825 indole-3-acetonitrile pathway nitrilase RCF35_09895 Others tryptophan...”
LOC110770067 aldehyde dehydrogenase family 3 member H1-like from Prunus avium
36% identity, 78% coverage
- Application of proteomics to determine the mechanism of ozone on sweet cherries (Prunus avium L.) by time-series analysis
Zhao, Frontiers in plant science 2023 - “...kinase, cytosolic isozyme -0.67 LOC110752150 A0A6P5S4L3 glyceraldehyde-3-phosphate dehydrogenase, cytosolic-like -0.66 LOC110767662 A0A6P5THS0 phosphoglucomutase, chloroplastic -0.63 LOC110770067 A0A6P5TS82 aldehyde dehydrogenase family 3 member H1-like -0.80 Oxidative phosphorylation (pavi00190) LOC110758582 A0A6P5SGU2 V-type proton ATPase subunit H -1.03 LOC110770218 A0A6P5TSZ9 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial -1.17 LOC110766344...”
- “...LOC110753288 A0A6P5RYK4 lysophospholipid acyltransferase 1-like -1.26 LOC110766537 A0A6P5TEI1 aldo-keto reductase family 4 member C10-like -0.61 LOC110770067 A0A6P5TS82 aldehyde dehydrogenase family 3 member H1-like -0.80 LOC110771484 A0A6P5TWD0 1-acyl-sn-glycerol-3-phosphate acyltransferase 2 -1.61 LOC110760091 A0A6P5SUX0 D-glycerate 3-kinase, chloroplastic -0.73 Amino sugar and nucleotide sugar metabolism (pavi00520) LOC110771554 A0A6P5TXP5 glucose-1-phosphate...”
LOC127486773 aldehyde dehydrogenase family 3 member A2 from Oryctolagus cuniculus
38% identity, 91% coverage
- Transcriptomic Signatures of the Foetal Liver and Late Prenatal Development in Vitrified Rabbit Embryos
Vicente, Veterinary sciences 2024 - “...LOC127489097 (IFGGC1), LOC127489095 (IRGM1), UGT2B14, LOC100352702, LOC127491078 (MPST), and LOC127489092, and upregulated genes such as LOC127486773 (ALDH3A2), PLA2G4C, ERICH3, LOC103348263 (DERPC-like), LOC100338442 (EEF1AKMT1), LOC127489132 (COG8), LOC103347040, LOC100353617 (NR5A2-like), INHBE, and LOC100349068 (AP-1) were the top 10 exhibiting the greatest significant difference in expression (i.e., absolute FC...”
ALDH3-2 / Q16MV5 fatty aldehyde dehydrogenase 3 (EC 1.2.1.94) from Aedes aegypti (see paper)
Q16MV5 farnesal dehydrogenase (EC 1.2.1.94) from Aedes aegypti (see paper)
37% identity, 84% coverage
A0A5F9D390 Aldehyde dehydrogenase from Oryctolagus cuniculus
38% identity, 81% coverage
- Platelet-rich plasma promotes peripheral nerve regeneration after sciatic nerve injury
Wang, Neural regeneration research 2023 - “...chain 2 0.268081266 0.002029346 62854244 16850045.33 A0A5F9CV02 NFIA Nuclear factor 1 0.720929483 0.035980968 2512135.667 1811072.667 A0A5F9D390 ALDH3A2 Aldehyde dehydrogenase 0.574050367 0.032825781 800414.6667 459478.3333 A0A5F9DSK5 MECP2 Methyl-CpG-binding protein 2 0.777293892 0.021816219 1161047.333 902475 G1SD81 HK3 Hexokinase 0.520826636 0.04963183 61307421.33 31930538 G1SFZ8 UBQLN1 Ubiquilin 1 0.691693251 0.003030462 4741433.667...”
B1AV77 Aldehyde dehydrogenase from Mus musculus
39% identity, 84% coverage
AL3A2_MOUSE / P47740 Aldehyde dehydrogenase family 3 member A2; Aldehyde dehydrogenase 3; Fatty aldehyde dehydrogenase; EC 1.2.1.3; EC 1.2.1.94 from Mus musculus (Mouse) (see paper)
P47740 aldehyde dehydrogenase (NAD+) (EC 1.2.1.3) from Mus musculus (see paper)
39% identity, 85% coverage
- function: Catalyzes the oxidation of medium and long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length (PubMed:25286108). Responsible for conversion of the sphingosine 1- phosphate (S1P) degradation product hexadecenal to hexadecenoic acid (PubMed:25286108).
catalytic activity: an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+) (RHEA:16185)
catalytic activity: a fatty aldehyde + NAD(+) + H2O = a fatty acid + NADH + 2 H(+) (RHEA:49832)
catalytic activity: hexadecanoate + NADH + 2 H(+) = hexadecanal + NAD(+) + H2O (RHEA:33739)
catalytic activity: octanal + NAD(+) + H2O = octanoate + NADH + 2 H(+) (RHEA:44100)
catalytic activity: (2E)-hexadecenal + NAD(+) + H2O = (E)-hexadec-2-enoate + NADH + 2 H(+) (RHEA:36135)
catalytic activity: 22-oxodocosanoate + NAD(+) + H2O = docosanedioate + NADH + 2 H(+) (RHEA:39015)
catalytic activity: 2,6,10,14-tetramethylpentadecanal + NAD(+) + H2O = 2,6,10,14- tetramethylpentadecanoate + NADH + 2 H(+) (RHEA:44016)
catalytic activity: octadecanal + NAD(+) + H2O = octadecanoate + NADH + 2 H(+) (RHEA:44020)
catalytic activity: dodecanoate + NADH + 2 H(+) = dodecanal + NAD(+) + H2O (RHEA:44168)
catalytic activity: decanal + NAD(+) + H2O = decanoate + NADH + 2 H(+) (RHEA:44104)
catalytic activity: tetradecanal + NAD(+) + H2O = tetradecanoate + NADH + 2 H(+) (RHEA:44172)
catalytic activity: heptanal + NAD(+) + H2O = heptanoate + NADH + 2 H(+) (RHEA:44108)
catalytic activity: (2E,6E)-farnesal + NAD(+) + H2O = (2E,6E)-farnesoate + NADH + 2 H(+) (RHEA:24216)
subunit: Homodimer. - Preliminary proteomic analysis of mouse lung tissue treated with cyclophosphamide and Venetin-1
Czaplewska, Scientific reports 2024 - “...40S ribosomal protein S8 OS 0.1 P14148 DOWN Rpl7 60S ribosomal protein L7 OS 0.6 P47740 DOWN Aldh3a2 Ahd-3 Ahd3 Aldehyde dehydrogenase family 3 member A2 OS 0.5 P04919 DOWN Slc4a1 Ae1 Band 3 anion transport protein OS 0.5 Q8VCT4 DOWN Ces1d Ces1 Ces3 Carboxylesterase 1D...”
- Mass Spectrometric Profiling of Extraocular Muscle and Proteomic Adaptations in the mdx-4cv Model of Duchenne Muscular Dystrophy
Gargan, Life (Basel, Switzerland) 2021 - “...+5.93 P19536 Hydroxyacyl-coenzyme A dehydrogenase HADH 22 0.04369 +3.38 P17182 Alpha-enolase ENO1 19 0.04825 +3.13 P47740 Aldehyde dehydrogenase family 3 member A2 ALDH3A2 15 0.04301 +2.94 E9QNH7 Acyl-CoA-binding domain-containing protein 5 ACBD5 6 0.03134 +2.43 P07724 Albumin ALB 45 0.03520 +1.76 P19096 Fatty acid synthase FASN...”
- Adipocyte-Derived Extracellular Vesicles: State of the Art.
Rome, International journal of molecular sciences 2021 - “...acyltransferase, beta) Aifm2 Q8BUE4 apoptosis-inducing factor, mitochondrion-associated 2 Aldh2 P47738 aldehyde dehydrogenase 2, mitochondrial Aldh3a2 P47740 aldehyde dehydrogenase family 3, subfamily A2 Anxa1 P10107 annexin A1 Anxa6 P14824 annexin A6 Aoc3 O70423 amine oxidase, copper containing 3 Atp2a2 O55143 ATPase, Ca++ transporting, cardiac muscle, slow twitch...”
- Transcriptome analysis of genes and pathways associated with metabolism in Scylla paramamosain under different light intensities during indoor overwintering.
Li, BMC genomics 2020 - “...in both the LL and HL groups. In the LL group, fatty aldehyde dehydrogenase (ID: P47740) was the most down-regulated gene (0.31-fold), followed by alcohol dehydrogenase class-3 (ID: P79896, 0.38-fold) and hydroxyacyl-coenzyme A dehydrogenase (ID: Q16836; 0.44-fold) (Table 1 ). In the HL group, the three...”
- “...beta Q99JY0 0.4686 0.0035 Alcohol dehydrogenase class-3 P79896 0.3836 0.0010 0.4089 0.0005 Fatty aldehyde dehydrogenase P47740 0.3161 0.0193 Functional annotation Gene Ontology (GO) terms could be divided into three ontologies: cellular components, molecular function, and biological processes. In the LL group, 49 GO terms were assigned...”
- Mice depleted for Exchange Proteins Directly Activated by cAMP (Epac) exhibit irregular liver regeneration in response to partial hepatectomy.
Sivertsen, Scientific reports 2019 - “...A thioesterase 4 1.78, ns 1.95 Q9R0H0 Acox1 Peroxisomal acyl-coenzyme A oxidase 1 1.25 1.46 P47740 Aldh3a2 Fatty aldehyde dehydrogenase 1.48, ns 2.75 P52825 Cpt2 Carnitine O-palmitoyltransferase 2, mitochondrial 1.02, ns 1.24 P47934 Crat Carnitine O-acetyltransferase 1.59, ns 1.92 O88833 Cyp4a10 Cytochrome P450 4A10 2.01, ns...”
- Proteomic profiling of liver tissue from the mdx-4cv mouse model of Duchenne muscular dystrophy
Murphy, Clinical proteomics 2018 - “...P09813 Apoa2 Apolipoprotein A-II 2 9.5295 0.00130 6.98 P16045 Lgals1 Galectin-1 2 4.2800 0.00138 6.51 P47740 Aldh3a2 Fatty aldehyde dehydrogenase 7 24.1473 0.00055 6.02 P43883 Plin2 Perilipin-2 4 10.1732 0.02351 5.71 Q9DBE0 Csad Cysteine sulfinic acid decarboxylase 13 41.5240 0.00220 5.63 P13745 Gsta1 Glutathione S-transferase A1...”
- Subproteomic profiling of sarcolemma from dystrophic mdx-4cv skeletal muscle.
Murphy, Data in brief 2018 - “...3 80.5 2.01E-05 3.9 Q8BY89 Slc44a2 Choline transporter-like protein 2 2 2 54.5 7.41E-04 3.8 P47740 Aldh3a2 Fatty aldehyde dehydrogenase 2 2 101.6 2.89E-05 3.8 P22315 Fech Ferrochelatase, mitochondrial 2 2 3.6 2.79E-03 3.8 P80318 Cct3 T-complex protein 1 subunit gamma 2 2 65.6 4.94E-05 3.7...”
- Proteomic analysis of host brain components that bind to infectious particles in Creutzfeldt-Jakob disease.
Kipkorir, Proteomics 2015 - “...Eef1a2 1.438 2.710 0.108 0.000 12 P39053 DYN1_MOUSE Dynamin-1 Dnm1 1.325 2.505 0.533 0.024 13 P47740 AL3 A2_MOUSE Fatty aldehyde dehydrogenase Aldh3a2 1.268 2.408 0.065 0.000 14 P09055 ITB1_MOUSE Integrin beta-1 Itgb1 1.128 2.185 0.131 0.000 15 P55088 AQP4_MOUSE Aquaporin-4 Aqp4 1.092 2.132 0.079 0.000 16...”
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B1ATI0 Aldehyde dehydrogenase from Mus musculus
39% identity, 78% coverage
XP_006532094 aldehyde dehydrogenase family 3 member A2 isoform X2 from Mus musculus
39% identity, 85% coverage
BTH_I0192 coniferyl aldehyde dehydrogenase from Burkholderia thailandensis E264
38% identity, 91% coverage
G3V9W6 Aldehyde dehydrogenase family 3 member A2 from Rattus norvegicus
38% identity, 74% coverage
- Inflammation and apoptosis accelerate progression to irreversible atrophy in denervated intrinsic muscles of the hand compared with biceps: proteomic analysis of a rat model of obstetric brachial plexus palsy.
Yu, Neural regeneration research 2020 - “...P17764, Q9WVK7, Q9WVK3, P08503, P70584, P14604, Q5M9H2, Q63704 0.002 Pathways at 5 weeks Glycolysis/gluconeogenesis 29 G3V9W6 * , P25113 * , D3ZZN3, P07323, P30835, A0A0G2JZH8, Q6P9U7, E9PTN6, D4A5G8, Q9Z1N1, B1WBN9, P49432, E9PTV9, Q6P6R2, P08461, P27881, P09117, P16617, P42123, P48500, Q6P6G4, Q6P6V0, Q499Q4, M0R660, P16290, P15429, P11980,...”
- “...A0A0G2K9C8, A1L1M0, P10688, F1LLZ7, Q05962, Q9Z2L0, B3XZL8, F1LPJ2, Q304F3, Q64578 < 0.001 Pyruvate metabolism 20 G3V9W6 * , D3ZJH9, D3ZZN3, A0A0G2K4C6, A0A0G2JZH8, Q6P9U7, D4A5G8, B1WBN9, P17764, P49432, P35745, Q6P6R2, P08461, B0BN46, P14408, P42123, O88989, Q6P7Q4, P04636, P11980 < 0.001 a Expression of proteins was compared between...”
- Quantitative Proteomic Analysis Reveals Molecular Adaptations in the Hippocampal Synaptic Active Zone of Chronic Mild Stress-Unsusceptible Rats.
Zhou, The international journal of neuropsychopharmacology 2015 - “...0.53 0.54 Mitochondrial Q5HZW3 Aspartate beta-hydroxylase domain-containing protein 2 Asphd2 4 3 1.60 2.25 Metabolic G3V9W6 Aldehyde dehydrogenase Aldh3a2 4 6 1.65 1.36 Metabolic Q5XI31 GPI transamidase component PIG-S Pigs 4 3 1.23 Metabolic Q66HL0 5 nucleotidase, ecto Nt5e 8 8 1.47 Metabolic D3ZPU3 Estradiol 17-beta-dehydrogenase...”
XP_004502482 aldehyde dehydrogenase family 3 member H1-like isoform X1 from Cicer arietinum
36% identity, 86% coverage
- Aldehyde Dehydrogenase 3 Is an Expanded Gene Family with Potential Adaptive Roles in Chickpea
Carmona-Molero, Plants (Basel, Switzerland) 2021 - “...XM_004501904 15 XP_004501961 503 54.53 1 5.37 CaALDH3H2 LOC101510937 Ca5 44,008,221 44,002,223 - XM_004502425 11 XP_004502482 488 53.18 3 7.01 CaALDH3H4 LOC101511680 Ca5 44,024,284 44,016,817 - XM_004502428 10 XP_004502485 486 52.99 1 8.33 CaALDH18B2 LOC101490622 Ca6 1,317,458 1,311,762 - XM_012716567 21 XP_012572021 715 77.65 1 6.62...”
XP_006246591 aldehyde dehydrogenase family 3 member A2 isoform X1 from Rattus norvegicus
38% identity, 71% coverage
AL3A2_RAT / P30839 Aldehyde dehydrogenase family 3 member A2; Aldehyde dehydrogenase 4; Fatty aldehyde dehydrogenase; Microsomal aldehyde dehydrogenase; msALDH; EC 1.2.1.3; EC 1.2.1.94 from Rattus norvegicus (Rat) (see paper)
38% identity, 86% coverage
- function: Catalyzes the oxidation of medium and long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid (By similarity).
catalytic activity: an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+) (RHEA:16185)
catalytic activity: a fatty aldehyde + NAD(+) + H2O = a fatty acid + NADH + 2 H(+) (RHEA:49832)
catalytic activity: (2E)-hexadecenal + NAD(+) + H2O = (E)-hexadec-2-enoate + NADH + 2 H(+) (RHEA:36135)
catalytic activity: hexadecanoate + NADH + 2 H(+) = hexadecanal + NAD(+) + H2O (RHEA:33739)
catalytic activity: 22-oxodocosanoate + NAD(+) + H2O = docosanedioate + NADH + 2 H(+) (RHEA:39015)
catalytic activity: 2,6,10,14-tetramethylpentadecanal + NAD(+) + H2O = 2,6,10,14- tetramethylpentadecanoate + NADH + 2 H(+) (RHEA:44016)
catalytic activity: octadecanal + NAD(+) + H2O = octadecanoate + NADH + 2 H(+) (RHEA:44020)
catalytic activity: dodecanoate + NADH + 2 H(+) = dodecanal + NAD(+) + H2O (RHEA:44168)
catalytic activity: decanal + NAD(+) + H2O = decanoate + NADH + 2 H(+) (RHEA:44104)
catalytic activity: tetradecanal + NAD(+) + H2O = tetradecanoate + NADH + 2 H(+) (RHEA:44172)
catalytic activity: octanal + NAD(+) + H2O = octanoate + NADH + 2 H(+) (RHEA:44100)
catalytic activity: heptanal + NAD(+) + H2O = heptanoate + NADH + 2 H(+) (RHEA:44108)
catalytic activity: (2E,6E)-farnesal + NAD(+) + H2O = (2E,6E)-farnesoate + NADH + 2 H(+) (RHEA:24216)
subunit: Homodimer. - The Multienzyme Complex Nature of Dehydroepiandrosterone Sulfate Biosynthesis.
Tumilovich, International journal of molecular sciences 2024 - “...P29147 1 5.8 Pfkl ATP-dependent 6-phosphofructokinase, liver type P30835 1 1.2 Aldh3a2 Fatty aldehyde dehydrogenase P30839 1 1.9 Gnb2 * Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 P54313 1 4.1 Gnb4 * Guanine nucleotide-binding protein subunit beta-4 O35353 Sult1c2a * Sulfotransferase 1C2a Q9WUW9 1 3.7 Sult1c2 *...”
- The Influence of Lipid Microdomain Heterogeneity on Protein-Protein Interactions: Proteomic Analysis of Co-Immunoprecipitated Binding Partners of P450 1A2 and P450 3A in Rat Liver Microsomes
Reed, Drug metabolism and disposition: the biological fate of chemicals 2023 (secret) - Extracellular vesicles released by steatotic hepatocytes alter adipocyte metabolism
Mleczko, Journal of extracellular biology 2022 - “...mitochondrial RL32_RAT P62912 0.91 3.49E02 60S ribosomal protein L32 CALR_RAT P18418 0.93 1.95E02 Calreticulin AL3A2_RAT P30839 0.93 1.80E02 Fatty aldehyde dehydrogenase GNAI2_RAT P04897 0.96 1.36E02 Guanine nucleotidebinding protein G(i) subunit alpha2 HACL1_RAT Q8CHM7 0.99 6.17E03 2hydroxyacylCoA lyase 1 GRP78_RAT P06761 1.02 7.38E03 78kDa glucoseregulated protein GBLP_RAT...”
- Possible Role of Extracellular Vesicles in Hepatotoxicity of Acetaminophen.
Šrajer, International journal of molecular sciences 2022 - “..., 34 ] 07687 Epoxide hydrolase 1 6 20.88 Hepatocytes, Endothelial cells [ 23 ] P30839 Aldehyde dehydrogenase 6 17.77 Hepatocytes, Some non-parenchymal cells [ 23 ] P02793 Ferritin light chain 1 5 6.183 Hepatocytes Macrophages [ 35 ] P63259 Actin, cytoplasmatic 2 5 9.51 Ubiquitous...”
- Investigation on Intestinal Proteins and Drug Metabolizing Enzymes in Simulated Microgravity Rats by a Proteomics Method.
Liu, Molecules (Basel, Switzerland) 2020 - “...(HK2) 2.58 0.0214 P05708 Hexokinase-1 (HK1) 2.40 0.0031 P11884 mitochondrial Aldehyde dehydrogenase (ALDH2) 2.33 0.0005 P30839 Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 2.17 0.0005 P30835 ATP-dependent 6-phosphofructokinase, liver type (PFK) 0.49 0.0078 P00884 Fructose-bisphosphate aldolase B (ALDOB) 0.20 0.0002 P06757 Alcohol dehydrogenase 1 (ADH1) 0.12...”
- “...2.49 0.0001 P11884 mitochondrial Aldehyde dehydrogenase (ALDH2) 2.33 0.0005 Q66HG3 Beta-Ala-His dipeptidase (CNDP1) 2.33 0.0146 P30839 Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 2.17 0.0005 O35854 Mitochondrial branched-chain-amino-acid aminotransferase (BCAT2) 2.06 0.0042 Q5QE78 Aldehyde oxidase 2 (AOX2) 0.41 0.00002 molecules-25-04391-t003_Table 3 Table 3 Results of metabolic...”
- Functional proteomic analysis of corticosteroid pharmacodynamics in rat liver: Relationship to hepatic stress, signaling, energy regulation, and drug metabolism.
Ayyar, Journal of proteomics 2017 - “...P06757 Adh1 Alcohol dehydrogenase 1 Conversion of primary unbranched alcohols to their corresponding aldehydes UP P30839 Aldh3a2 Aldehyde dehydrogenase 4, microsomal Oxidation of long-chain aliphatic aldehydes to fatty acids UP/DOWN Q8BH00 Aldh8a1 Aldehyde dehydrogenase family 8 member A1 Converts 9-cis-retinal to 9-cis-retinoic acid UP Q66HF8 Aldh1b1...”
- Acetaminophen Induced Hepatotoxicity in Wistar Rats--A Proteomic Approach.
Ilavenil, Molecules (Basel, Switzerland) 2016 - “...27 3409 3,2-trans-enoyl-CoA isomerase, 32 35.5 6.6 P23965 28 M6 Cytochrome P450 54 60.7 6.8 P30839 29 5807 Growth factor receptor-bound protein 14 36 61.5 7.4 O88900 30 6710 Methionine aminopeptidases 2 49 53.2 7.8 P38062 31 1206 Trypsin I, anionic precursor 51 27.2 5.5 P00762...”
- “...2710 CYP2B3 28 24 54.8 6.3 P13107 30 M6 Cytochrome P450 30 24 60.7 6.8 P30839 31 8305 Kinesin heavy chain isoform 33 32 32 7802 (Pyruvate dehydrogenase (Lipoamide))-phosphatase 2 38 31 60 8.5 O88484 33 7602 Transforming growth factor beta 1 precursor 36 35 48.2...”
- The protein partners of GTP cyclohydrolase I in rat organs.
Du, PloS one 2012 - “...acid metabolism, Lipid metabolism P04904 Glutathione S-transferase alpha-3 Conjugation of reduced glutathione to hydrophobic electrophiles P30839 Fatty aldehyde dehydrogenase formaldehyde metabolic process, oxidation-reduction process, response to reactive oxygen species P63036 DnaJ homolog subfamily A member 1 DNA damage response, detection of DNA damage P16970 ATP-binding cassette...”
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XP_001655925 aldehyde dehydrogenase, dimeric NADP-preferring from Aedes aegypti
37% identity, 84% coverage
AL3H1_ARATH / Q70DU8 Aldehyde dehydrogenase family 3 member H1; AtALDH4; Ath-ALDH4; EC 1.2.1.3 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
Q70DU8 aldehyde dehydrogenase (NAD+) (EC 1.2.1.3) from Arabidopsis thaliana (see paper)
NP_175081 aldehyde dehydrogenase 3H1 from Arabidopsis thaliana
AT1G44170 ALDH3H1 (ALDEHYDE DEHYDROGENASE 3H1); 3-chloroallyl aldehyde dehydrogenase/ aldehyde dehydrogenase (NAD) from Arabidopsis thaliana
36% identity, 88% coverage
- function: Involved in oxidative stress tolerance by detoxifying reactive aldehydes derived from lipid peroxidation. Medium- to long- chain saturated aldehydes are preferred substrates, while the short- chain aldehyde propanal is a weak substrate. Is strictely NAD(+) specific.
catalytic activity: an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+) (RHEA:16185)
subunit: Homodimer and homomultimer.
disruption phenotype: Increased sensitivity to salt stress. - S-Nitrosation impairs activity of stress-inducible aldehyde dehydrogenases from Arabidopsis thaliana.
Stiti, Plant science : an international journal of experimental plant biology 2020 (PubMed)- GeneRIF: S-Nitrosation impairs activity of stress-inducible aldehyde dehydrogenases from Arabidopsis thaliana.
- Aldehyde dehydrogenase enzyme ALDH3H1 from Arabidopsis thaliana: Identification of amino acid residues critical for cofactor specificity.
Stiti, Biochimica et biophysica acta 2014 (PubMed)- GeneRIF: experiments suggest that residues occupying positions equivalent to 149, 178 and 200 constitute a group of amino acids in the ALDH3H1 protein determining cofactor affinity
- T-DNA insertion mutants reveal complex expression patterns of the aldehyde dehydrogenase 3H1 locus in Arabidopsis thaliana.
Missihoun, Journal of experimental botany 2012 - GeneRIF: ALDH3H1 locus generates at least five alternative transcript variants.
- Comparative gene expression profile analysis of ovules provides insights into Jatropha curcas L. ovule development
Xu, Scientific reports 2019 - “...YUCCA8 (Arabidopsis thaliana) Q9SVU0 1.504 c25692_g3 Aldehyde dehydrogenase family 3 member H1(ALDH3 H1) (Arabidopsis thaliana) Q70DU8 1.096 c14699_g1 Aldehyde dehydrogenase family 2 member B4(ALDH2 B4-1) , (Arabidopsis thaliana) Q9SU63 0.737 c20408_g1 Aldehyde dehydrogenase family 2 member B4(ALDH2 B4-2) , (Arabidopsis thaliana) Q9SU63 0.688 c29730_g3 Cytosolic sulfotransferase...”
- The chloroplast protein HCF164 is predicted to be associated with Coffea SH9 resistance factor against Hemileia vastatrix
Guerra-Guimarães, Scientific reports 2023 - “...Phosphoglycerate kinase (PGKP2, AT1G56190); Phosphoglycerate mutase (PGAM1, AT1G22170); Glyoxylate/hydroxypyruvate reductase (HPPR2, AT1G79870); Glyceraldehyde-3-phosphate dehydrogenases (ALDH3H1, AT1G44170; ALDH7B4; ALDH2B4, AT3G48000; ALDH2B7); Superoxide dismutase [CuZn] 1 and 2 (CSD; AT1G08830, AT2G28190); Peroxiredoxin II A, D and E (PRXII; AT1G65990, AT1G60740, AT3G52960) and 2-Cys-peroxiredoxin A and B (2CP; AT3G11630,...”
- Trans-cinnamaldehyde-related overproduction of benzoic acid and oxidative stress on Arabidopsis thaliana
López-González, Frontiers in plant science 2023 - “...AT1G23800 CATGAGGCTGGACTTCCTGA/ACCCGGTGAAAGCAACCTTA 112 2.000 ALDH2C4 AT3G24503 TGATATTGACAAAGCCGCCG/AGGATCACCAACGGTCCAAT 160 2.001 ALDH3F1 AT4G36250 TCGCGCCTACTCTGATTGAT/AGACGATGGAAGCTTGGACA 159 2.001 ALDH3H1 AT1G44170 TTTGGCCCTCTCCTTCCAAT/TGACTACTATGCCTCCAGCG 160 1.995 ALDH3I1 AT4G34240 TCACTGGTGGAGCAAGAGTT/GATCCTCCTAGCAGCCACTT 140 1.995 ALDH7B4 AT1G54100 TCAGAACGCCCTAACCACAT/CACCACACATGGCCGTAAAA 250 2.001 ALDH11A3 AT2G24270 CCGATAGCTTCCCCGGTAAT/GGAGGTTTGAGGACAAGGGA 163 1.995 ALDH22A1 AT3G66658 CTTTCTGAGGGCGAACGATG/CACCAAGGGGATGGAACTCT 97 2.000 Gene expression analyses were performed following the...”
- Divergent selection and climate adaptation fuel genomic differentiation between sister species of Sphagnum (peat moss)
Piatkowski, Annals of botany 2023 - “...Sphmag08G014600 AT5G10720 (HK5) Histidine kinase Yes AT1G44170 (ALDH3H1) Aldehyde dehydrogenase Yes AT3G49600 (UBP26) Ubiquitin-specific protease Yes AT3G30530...”
- Genomically Hardwired Regulation of Gene Activity Orchestrates Cellular Iron Homeostasis in Arabidopsis
Hsieh, RNA biology 2022 - “...ACO3, At2g05710; IAR4, At1g24180; MAB1, At5g50850; HOT5, At5g43940; ADH, At4g22110; ALDH2B7, At1g23800; ALDH2B4, At3g48000; ALDH3H1, At1g44170; PCK1, At4g37870; PPC1, At1g53310; IRT3, At1g60960; BGLU42, At5g36890; BTSL2, At1g18910; GRF11, At1g34760. Author contributions E.J.H. and W.S. designed the research; E.J.H. performed the experiments; E.J.H., W.D.L and W.S. analysed the...”
- 4D genetic networks reveal the genetic basis of metabolites and seed oil-related traits in 398 soybean RILs
Han, Biotechnology for biofuels and bioproducts 2022 - “...] GmALDH2 New mQTL-P8 6 Marker1993733, Marker2000797 0.55~ 0.32 2.87~4.51 3.06~5.77 Amino acid beta-Alanine Glyma06g12010 AT1G44170 gmx00410 Shin et al. [ 118 ] GmSD Known mQTL-P21 15 Marker12570, Marker12570 0.77~0.68 2.87~4.55 2.24~4.15 Ethanolamine Glyma15g05630 AT1G43710 gmx00340 Yunus et al. [ 119 ] GmFUS3 New mQTL-P22 16...”
- New Insights into the Chloroplast Outer Membrane Proteome and Associated Targeting Pathways
Fish, International journal of molecular sciences 2022 - “...* TIC236 At3g52230 OMP24 Homolog At3g63160 OEP6 Multi-Pass -Helical Proteins At1g12230 Transaldolase At1g34430 PDC E2 At1g44170 ALDH3H1 At1g54150 * E3 Ubiquitin-Protein Ligase SPL2 At1g59560 * E3 Ubiquitin-Protein Ligase SPL1 At1g63900 SP1 At1g64850 - At1g68680 - At1g77590 LACS9 At2g01320 WBC7 At2g11810 MGD3 At2g28900 OEP16-1 At2g34590 PDC E1...”
- De Novo Transcriptome Sequencing of Rough Lemon Leaves (Citrus jambhiri Lush.) in Response to Plenodomus tracheiphilus Infection
Russo, International journal of molecular sciences 2021 - “...AOS Allene oxide synthase AT5G42650 +9.59 67% 6 10 26 14701,29676 ALDH3H1 Aldehyde dehydrogenase 3H1 AT1G44170 +3.70 68% 3 10 6 Reactive oxygenGlutathione metabolism 14701,7488 GSTU19 Glutathione S-transferase TAU 19 AT1G78380 +7.58 70% 1 10 56 14701,35413 GSTU10 Glutathione S-transferase TAU 10 AT1G74590 +5.23 73% 1...”
- A sweet orange mutant impaired in carotenoid biosynthesis and reduced ABA levels results in altered molecular responses along peel ripening
Romero, Scientific reports 2019 - “...SYNTHASE 1) 0.22 0.85 1.18 aCL638Contig2 AT4G04020 PGL35 (PLASTOGLOBULIN 35) 1.08 0.18 1.06 * aCL5206Contig1 AT1G44170 ALDH3-H1 (ALDEHYDE DEHYDROGENASE 3 H1) 1.45 0.39 0.99 Defense response to fungus (GO:0009817; Level 6) aCL5483Contig1 AT3G21630 CERK1 (CHITIN ELICITOR RECEPTOR KINASE 1) 1.77 0.00 1.64 aC34202B10EF_c AT1G29340 PUB17 (PLANT...”
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M5XBG8 Aldehyde dehydrogenase from Prunus persica
36% identity, 84% coverage
- Proteome-wide identification and functional analysis of ubiquitinated proteins in peach leaves
Song, Scientific reports 2020 - “...photosynthesis, including two pyruvate kinases (M5W5K0 and M5WMV6, EC. 2.7.1.40), two aldehyde dehydrogenases (A0A251RFC2 and M5XBG8, EC. 1.2.1.3), two fructose-biphosphate aldolases (M5VYU7 and M5W2H9, EC. 4.1.2.13), two ribulose bisphosphate carboxylases (large chain, RUBISCO, E3W0K1 and M5XB14, EC. 4.1.1.39), one phosphoglycerate kinase (M5X0L9, EC. 2.7.2.3), one 6-phosphofructokinase...”
- “...in our current study are colored in red as follows: 2.7.1.40, M5W5K0 and M5WMV6; 1.2.1.3, M5XBG8; 4.1.2.13, M5VYU7 and M5W2H9; 4.1.1.39 E3W0K1 and M5XB14; 2.7.1.11, M5XC66; 1.2.1.12, M5XQ59; 1.1.1.37, M5Y9C1; 5.3.1.1 M5X2A0; 4.2.1.11 M5VPR4; 1.1.1.1 M5VJ94. Source: Kanehisa et al . 62 . Our proteomic investigation...”
GRMZM2G103546 aldehyde dehydrogenase, dimeric NADP-preferring from Zea mays
37% identity, 85% coverage
Q6C0L0 Aldehyde dehydrogenase from Yarrowia lipolytica (strain CLIB 122 / E 150)
37% identity, 79% coverage
Q54DG1 Aldehyde dehydrogenase family 3 comG from Dictyostelium discoideum
37% identity, 89% coverage
PA0366 probable aldehyde dehydrogenase from Pseudomonas aeruginosa PAO1
36% identity, 89% coverage
- Sulfate Ester Detergent Degradation in Pseudomonas aeruginosa Is Subject to both Positive and Negative Regulation
Panasia, Applied and environmental microbiology 2019 (secret) - LaoABCR, a Novel System for Oxidation of Long-Chain Alcohols Derived from SDS and Alkane Degradation in Pseudomonas aeruginosa
Panasia, Applied and environmental microbiology 2018 - “...(PA0364) & LaoB (PA0365) 1-dodecanal O aldehyde dehydrogenase LaoC (PA0366) O lauric acid OH acyl-CoA synthetase O lauroyl-CoA CoA S b laoA laoB laoC laoR...”
- “...bold. (b) Map of gene cluster laoABC (PA0364 to PA0366) and the adjacent gene laoR (PA0367) in P. aeruginosa strain PAO1. Shadings indicate the postulated...”
- Genomic and Functional Characterization of Environmental Strains of SDS-Degrading Pseudomonas spp., Providing a Source of New Sulfatases
Furmanczyk, Frontiers in microbiology 2018 - “...degradation of SDS were proposed, including the sdsA1 (coding alkylsulfatase) or putative dehydrogenases (PA0364 and PA0366) possibly responsible for further oxidation steps after the hydrolysis of SDS to dodecanol ( Klebensberger et al., 2009 ). These suggestions were recently confirmed by mutants analysis and resulted in...”
- Integrated whole-genome screening for Pseudomonas aeruginosa virulence genes using multiple disease models reveals that pathogenicity is host specific
Dubern, Environmental microbiology 2015 - “...Y PA0337 ptsP Transport of small molecules + + + (Feinbaum etal ., 2012 ) PA0366 Putative enzymes + + + PA0396 pilU Motility and attachment + + + Y PA0425 mexA Transport of small molecules + + + PA0534 pauB1 Carbon compound catabolism + +...”
- Genetic adaptation of Pseudomonas aeruginosa to the airways of cystic fibrosis patients is catalyzed by hypermutation
Mena, Journal of bacteriology 2008 - “...fleQ (PA1097), mexT (PA2492), nalD (PA3574), ampD (PA4522), PA0366, cyaB (PA3217), P1-001 (in a 45-kb genomic island), PA3817, pilB (PA4526), PA1333, PA3565,...”
- Genetic adaptation by Pseudomonas aeruginosa to the airways of cystic fibrosis patients
Smith, Proceedings of the National Academy of Sciences of the United States of America 2006 - “...*fleQ PA4462 PA1097 mexT PA2492 *nalD PA3574 *ampD PA4522 PA0366 *cyaB PA3217 P1-001 In 45-kb genomic island PA3817 pilB PA4526 PA1333 PA3565 PA2312 *anr PA1544...”
- A cystic fibrosis epidemic strain of Pseudomonas aeruginosa displays enhanced virulence and antimicrobial resistance
Salunkhe, Journal of bacteriology 2005 - “...PA0050 PA0059 PA0106 PA0107 PA0122 PA0143 PA0176 PA0355 PA0364 PA0366 PA0447 PA0567 PA0586 PA0588 PA0852 PA0996 PA0997 H2 O 2 LES431 1 vs LES400 4912 J....”
- Identification, timing, and signal specificity of Pseudomonas aeruginosa quorum-controlled genes: a transcriptome analysis
Schuster, Journal of bacteriology 2003 - “...PA0175 PA0176 PA0179 PA0198 PA0263 PA0355 PA0364 PA0365 PA0366 PA0534 PA0567 PA0572 PA0586 PA0852 PA0855 PA0996 PA0997 PA0998 PA0999 PA1000 PA1001 PA1002 PA1003...”
- More
aldh3H1 / CAE51203.1 putative aldehyde dehydrogenase, partial from Arabidopsis thaliana (see paper)
36% identity, 89% coverage
Maqu_3572 aldehyde dehydrogenase from Marinobacter aqueolei
36% identity, 88% coverage
C4QXC1 Aldehyde dehydrogenase from Komagataella phaffii (strain GS115 / ATCC 20864)
33% identity, 84% coverage
- Lipidome and proteome of lipid droplets from the methylotrophic yeast Pichia pastoris.
Ivashov, Biochimica et biophysica acta 2013 - “...synthetase Fat1p (49%) ER/LD/PM Long-chain fatty acid transport, very long chain fatty acid metabolic process C4QXC1 Putative fatty aldehyde dehydrogenase Hfd1p (43%) E/LD/M Cellular aldehyde metabolic process C4R2Z6 NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase Ayr1p (52%) ER/LD/C/M Phosphatidic acid biosynthetic process C4QW07 Steryl ester hydrolase, one of...”
LOC105159459 aldehyde dehydrogenase from Sesamum indicum
36% identity, 89% coverage
K2MRC3 Aldehyde dehydrogenase from Trypanosoma cruzi marinkellei
39% identity, 83% coverage
ALDH_CRAPL / Q8VXQ2 Aldehyde dehydrogenase; Cp-ALDH; EC 1.2.1.3 from Craterostigma plantagineum (Blue gem) (Torenia plantagineum) (see paper)
ALDH / CAC84900.1 aldehyde dehydrogenase from Craterostigma plantagineum (see paper)
36% identity, 87% coverage
- function: Oxidizes nonanal, propionaldehyde and acetaldehyde in vitro, in the following decreasing order of reactivity: nonanal, propionaldehyde, acetaldehyde.
catalytic activity: an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+) (RHEA:16185)
aldh3F1 / CAE48163.1 putative aldehyde dehydrogenase from Arabidopsis thaliana (see paper)
36% identity, 86% coverage
LOC101511680, XP_004502485 aldehyde dehydrogenase family 3 member H1-like from Cicer arietinum
35% identity, 87% coverage
- Aldehyde Dehydrogenase 3 Is an Expanded Gene Family with Potential Adaptive Roles in Chickpea
Carmona-Molero, Plants (Basel, Switzerland) 2021 - “...candidates to have undergone local gene duplications. We found two genes on chromosome 5 (LOC101510937, LOC101511680) and two genes on chromosome 8 (LOC101513875, LOC101514219) that met the criteria to form a cluster as described in Section 3.2 . These two pairs of genes are separated by...”
- “...showed a larger count number in inoculated plants ( Figure 4 ). Interestingly, LOC101515558 and LOC101511680 ( ALDH3H3 and ALDH3H4 , respectively), which are duplicated with LOC101510937 ( Figure S1 ), show a different expression pattern, as they are not differentially abundant in any condition. This...”
- “...XM_004502425 11 XP_004502482 488 53.18 3 7.01 CaALDH3H4 LOC101511680 Ca5 44,024,284 44,016,817 - XM_004502428 10 XP_004502485 486 52.99 1 8.33 CaALDH18B2 LOC101490622 Ca6 1,317,458 1,311,762 - XM_012716567 21 XP_012572021 715 77.65 1 6.62 CaALDH2C5 LOC101493969 Ca6 3,278,797 3,283,156 + XM_004503375 10 XP_004503432 480 52.33 1 6.44...”
AL3F1_ARATH / Q70E96 Aldehyde dehydrogenase family 3 member F1; EC 1.2.1.3 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
AT4G36250 ALDH3F1 (Aldehyde Dehydrogenase 3F1); 3-chloroallyl aldehyde dehydrogenase/ aldehyde dehydrogenase (NAD) from Arabidopsis thaliana
NP_195348 aldehyde dehydrogenase 3F1 from Arabidopsis thaliana
36% identity, 86% coverage
- catalytic activity: an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+) (RHEA:16185)
subunit: Homotetramer. - Mapping the Influence of Light Intensity on the Transgenerational Genetic Architecture of Arabidopsis thaliana
Mei, Current issues in molecular biology 2024 - “...A/A upstream_gene Serine acetyltransferase 3;2 AT4G36090 17079871 4 T/T synonymous Oxidoreductase, 2OG-Fe(II) oxygenase family protein AT4G36250 17151190 4 A/A synonymous Aldehyde dehydrogenase 3F1 AT4G36360 17183722 4 T/T upstream_gene Beta-galactosidase 3 Other AT2G14310 6070613 2 A/A upstream_gene Pseudo AT4G35660 16912804 4 T/T missense Selection/upkeep of intraepithelial T-cell...”
- Mitochondrial ATP Synthase beta-Subunit Affects Plastid Retrograde Signaling in Arabidopsis
Liu, International journal of molecular sciences 2024 - “...marker genes ( AT5G46710 , MZA15.12 , AT4G37910 , HSP70-9 , AT1G20950 , F9H16.6 , AT4G36250 , and ALDH3F1 ) involved in mitochondrial dysfunction, chloroplast ROS, and PAP signaling pathways ( Figure S5 ), which follow the same gene expression pattern as carbon metabolism genes (...”
- Single-cell RNA-sequencing profiles reveal the developmental landscape of the Manihot esculenta Crantz leaves
Zang, Plant physiology 2023 - “...to the work described in this paper: 4CL3 Gramene: AT1G65060 4CL3 Araport: AT1G65060 ALDH3F1 Gramene: AT4G36250 ALDH3F1 Araport: AT4G36250 gl3 Gramene: AT5G41315 gl3 Araport: AT5G41315 LHCA5 Gramene: AT1G45474 LHCA5 Araport: AT1G45474 vascular tissue AmiGo: PO:0009015 epidermal cell AmiGo: PO:0004013 mesophyll cell AmiGo: PO:0004006 GL2 Gramene: AT1G79840...”
- Trans-cinnamaldehyde-related overproduction of benzoic acid and oxidative stress on Arabidopsis thaliana
López-González, Frontiers in plant science 2023 - “...AT3G48000 GGCGAAGTCATTGCTCATGT/TGCCATTGTCCCATGTCTCT 199 2.001 ALDH2B7 AT1G23800 CATGAGGCTGGACTTCCTGA/ACCCGGTGAAAGCAACCTTA 112 2.000 ALDH2C4 AT3G24503 TGATATTGACAAAGCCGCCG/AGGATCACCAACGGTCCAAT 160 2.001 ALDH3F1 AT4G36250 TCGCGCCTACTCTGATTGAT/AGACGATGGAAGCTTGGACA 159 2.001 ALDH3H1 AT1G44170 TTTGGCCCTCTCCTTCCAAT/TGACTACTATGCCTCCAGCG 160 1.995 ALDH3I1 AT4G34240 TCACTGGTGGAGCAAGAGTT/GATCCTCCTAGCAGCCACTT 140 1.995 ALDH7B4 AT1G54100 TCAGAACGCCCTAACCACAT/CACCACACATGGCCGTAAAA 250 2.001 ALDH11A3 AT2G24270 CCGATAGCTTCCCCGGTAAT/GGAGGTTTGAGGACAAGGGA 163 1.995 ALDH22A1 AT3G66658 CTTTCTGAGGGCGAACGATG/CACCAAGGGGATGGAACTCT 97 2.000 Gene expression...”
- Aldehyde dehydrogenase ALDH3F1 involvement in flowering time regulation through histone acetylation modulation on FLOWERING LOCUS C
Xu, Journal of integrative plant biology 2020 (PubMed) (secret) - Time-resolved interaction proteomics of the GIGANTEA protein under diurnal cycles in Arabidopsis
Krahmer, FEBS letters 2019 - “...TPR4 2 2.70E05 6.80E04 15 Y n.d. AT2G18915 LKP2 18 3.4E05 7.4E04 13 Y 15/0 AT4G36250 ALDH3F1 2 4.13E05 8.30E04 12 n n.d. AT1G68050 FKF1 9 1.3E05 3.8E04 12 Y 15/0 AT5G54770 THI1 2 0.00051 0.0044 11 n n.d. AT5G22800 EMB86 3 6.33E05 0.0011 11 n...”
- Aldehyde Dehydrogenases Function in the Homeostasis of Pyridine Nucleotides in Arabidopsis thaliana
Missihoun, Scientific reports 2018 - “...in Missihoun et al . 47 . The single mutant KO76 (SALK_091250) for ALDH3F1 ( At4g36250 ) carries a T-DNA insertion in the fourth exon. Double mutants KO6/62 , KO6/76 , KO6/69 , and KO69/76 were obtained by crossing the corresponding homozygous single mutants. The second...”
- The modulation of acetic acid pathway genes in Arabidopsis improves survival under drought stress
Rasheed, Scientific reports 2018 - “...0.98 0.74 0.74 AT1G44170 ALDH3H1 Cytoplasm 1 0.93 0.75 0.62 0.75 1.24 1.28 1.29 1.20 AT4G36250 ALDH3F1 Cytoplasm 1 0.88 1.31 1.34 1.40 0.91 0.96 0.92 0.34 AT1G79440 ALDH5F1 Mitochondria 1 0.87 0.87 0.99 1.33 1.09 1.05 0.86 0.90 AT2G14170 ALDH6B2 Mitochondria 1 0.79 0.55 0.33...”
- More
- Aldehyde dehydrogenase ALDH3F1 involvement in flowering time regulation through histone acetylation modulation on FLOWERING LOCUS C.
Xu, Journal of integrative plant biology 2020 (PubMed)- GeneRIF: Aldehyde dehydrogenase ALDH3F1 involvement in flowering time regulation through histone acetylation modulation on FLOWERING LOCUS C.
- Comparative gene expression profile analysis of ovules provides insights into Jatropha curcas L. ovule development
Xu, Scientific reports 2019 - “...(Arabidopsis thaliana) Q9C9D0 1.383 0.884 c24704_g1 Aldehyde dehydrogenase family 3 member F1(ALDH3 F1) (Arabidopsis thaliana) Q70E96 0.625 c26913_g1 YUCCA2 (Arabidopsis thaliana) Q9SVQ1 2.025 c28407_g1 YUCCA4 (Arabidopsis thaliana) Q9LFM5 0.937 Gibberellins c15206_g1 Gibberellin 2-beta-dioxygenase 2 (Pisum sativum) Q9XHM5 2.105 2.100 c25340_g1 Ent-kaurene oxidase (Arabidopsis thaliana) Q93ZB2 0.749...”
LOC101515558, XP_004498346 aldehyde dehydrogenase family 3 member H1 from Cicer arietinum
36% identity, 86% coverage
- Aldehyde Dehydrogenase 3 Is an Expanded Gene Family with Potential Adaptive Roles in Chickpea
Carmona-Molero, Plants (Basel, Switzerland) 2021 - “...CaALDH3H2 ) showed a larger count number in inoculated plants ( Figure 4 ). Interestingly, LOC101515558 and LOC101511680 ( ALDH3H3 and ALDH3H4 , respectively), which are duplicated with LOC101510937 ( Figure S1 ), show a different expression pattern, as they are not differentially abundant in any...”
- “...any of the conditions are shown in orange color, whereas the duplicated genes LOC101511680 and LOC101515558 are shown in grey color. Figure 5 Gene expression levels of LOC101511819 in response to Fusarium oxysporum . Samples are a pair of NIL made of inoculated vs. control roots...”
- “...XM_012713409 20 XP_012568863 717 77.75 2 5.96 CaALDH3H3 LOC101515558 Ca4 38,313,842 38,325,387 + XM_004498289 10 XP_004498346 488 53.06 1 8.43 CaALDH10A8 LOC101507930 Ca5 39,963,842 39,971,506 + XM_004501904 15 XP_004501961 503 54.53 1 5.37 CaALDH3H2 LOC101510937 Ca5 44,008,221 44,002,223 - XM_004502425 11 XP_004502482 488 53.18 3 7.01...”
CTRG_05010 conserved hypothetical protein from Candida tropicalis MYA-3404
35% identity, 61% coverage
AFUA_4G13500, Afu4g13500 aldehyde dehydrogenase, putative from Aspergillus fumigatus Af293
36% identity, 82% coverage
- Screening of Chemical Libraries for New Antifungal Drugs against Aspergillus fumigatus Reveals Sphingolipids Are Involved in the Mechanism of Action of Miltefosine
Dos, mBio 2021 - “...AFUA_8g02590), cytochrome P450 enzymes (AFUA_3g03930, AFUA_4G03800, and AFUA_2G04290), cell division control protein (AFUA_2G17110), aldehyde dehydrogenase (AFUA_4G13500), and isocitrate lyase (AFUA_4G13510) were downregulated in the smiA strain compared to the wild-type strain ( Fig.6C ). Accordingly, the RNA-seq data were validated by performing real-time PCR on 3...”
- “...( www.yeastgenome.org ); (v) AFUA_4G03800, encoding a cytochrome P450 alkane hydroxylase ( www.fungidb.org ); (vi) AFUA_4G13500, encoding a homologue of S. cerevisiae Hfd1p, a dehydrogenase involved in ubiquinone and sphingolipid metabolism, converting hexadecenal to hexadecenoic acid in sphingosine 1-phosphate catabolism, the human homologue of ALDH3A2, mutated...”
- Conservation of nucleosome positions in duplicated and orthologous gene pairs
Nishida, TheScientificWorldJournal 2012 - “...AFUA_1G10780 0.673590566 YDR262W AFUA_8G05360 0.668577442 YJR160C AFUA_3G01700 0.655149877 YBL087C AFUA_2G03380 0.654275917 YDR120C AFUA_3G04200 0.653965099 YMR110C AFUA_4G13500 0.649573592 YDR479C AFUA_2G01510 0.649340576 YLR307W AFUA_4G09940 0.641152119 YLL050C AFUA_5G10570 0.636927762 YMR011W AFUA_2G11520 0.631877767 YGR149W AFUA_3G08240 0.627253467 YKL125W AFUA_1G02590 0.626251676 YDL247W AFUA_3G01700 0.621782331 YHR165C AFUA_2G03030 0.616638486 YLR355C AFUA_3G14490 0.615946987 YLR307W AFUA_3G07210...”
- Transcriptomic and proteomic analyses of the Aspergillus fumigatus hypoxia response using an oxygen-controlled fermenter
Barker, BMC genomics 2012 - “...encoding genes in A. fumigatus , Afu2g00720 and Afu7g01000 (NAD + ) and Afu4g08600 and Afu4g13500 (NAD(P) + ), so it is possible that these enzymes, and not AldA, are utilized under hypoxic conditions to metabolize ethanol. Afu4g08600 does show a gradual increase in transcript by...”
- “...24 hours in hypoxia when ethanol levels are assumed to be higher, whereas Afu7g01000 and Afu4g13500 transcripts are reduced, although not to the same degree as aldA (Additional file 5 ). A recent proteomics study indicated that Afu7g01000 is most probably the major aldehyde dehydrogenase involved...”
LOC101219569 aldehyde dehydrogenase family 3 member H1 from Cucumis sativus
36% identity, 87% coverage
XP_001335979 aldehyde dehydrogenase family 3 member A2 from Danio rerio
35% identity, 85% coverage
CYPRO_1155 aldehyde dehydrogenase family protein from Cyclonatronum proteinivorum
39% identity, 88% coverage
SPRG_08456 hypothetical protein from Saprolegnia parasitica CBS 223.65
37% identity, 80% coverage
- Characterizing the Mechanisms of Metalaxyl, Bronopol and Copper Sulfate against Saprolegnia parasitica Using Modern Transcriptomics
Wang, Genes 2022 - “...metabolic pathways. PPI network analysis screened out three important proteins, and their corresponding genes were SPRG_08456, SPRG_03679 and SPRG_10775. Our results indicate that three antimicrobials inhibit S. parasitica growth by affecting multiple biological functions, including protein synthesis, oxidative stress, lipid metabolism and energy metabolism. Additionally, the...”
- “...nodes, each representing 1 protein and connected by 100 edges ( Figure 6 ). SDRG_06419 (SPRG_08456), followed by SDRG_07258 (SPRG_03679), SDRG_01993 (SPRG_04185), SDRG_06022 (SPRG_10775) and SDRG_06773 (SPRG_05141) presented the highest scores for degree centrality (DC), indicating that they were the most important factors for the network....”
R4YMB5 Aldehyde dehydrogenase from Oleispira antarctica RB-8
36% identity, 89% coverage
LOC103938024 aldehyde dehydrogenase family 3 member F1-like from Pyrus x bretschneideri
34% identity, 88% coverage
XP_004503899 aldehyde dehydrogenase family 3 member H1-like isoform X1 from Cicer arietinum
36% identity, 76% coverage
- Aldehyde Dehydrogenase 3 Is an Expanded Gene Family with Potential Adaptive Roles in Chickpea
Carmona-Molero, Plants (Basel, Switzerland) 2021 - “...XM_004503375 10 XP_004503432 480 52.33 1 6.44 CaALDH3H1 LOC101505038 Ca6 6,829,385 6,835,166 + XM_004503842 12 XP_004503899 542 59.76 2 7.96 CaALDH6B2 LOC101490310 Ca6 15,177,302 15,170,648 - XM_004504810 19 XP_004504867 539 57.63 1 7.08 CaALDH18B1 LOC101512568 Ca6 44,541,903 44,527,947 - XM_027335197 21 XP_027190998 759 82.38 4 6.82...”
LOC21396538 aldehyde dehydrogenase family 3 member H1 from Morus notabilis
36% identity, 85% coverage
- Genome-Wide Identification of Candidate Genes Associated with Heat Stress in Mulberry (Morus alba L.)
Jin, Current issues in molecular biology 2023 - “...(LOC21397545), methylcrotonoyl-CoA carboxylase subunit alpha (LOC21385626), probable enoyl-CoA hydratase 1 (LOC21392597), aldehyde dehydrogenase family 3 (LOC21396538) and alanine--glyoxylate aminotransferase (LOC21404820). In plants, the catabolism of amino acids is extremely important in metabolic stress (e.g., when there are limited carbohydrates during prolonged darkness or any other stress)....”
Q6C5T1 Aldehyde dehydrogenase from Yarrowia lipolytica (strain CLIB 122 / E 150)
36% identity, 80% coverage
TOL_0223 coniferyl aldehyde dehydrogenase from Thalassolituus oleivorans MIL-1
34% identity, 89% coverage
SLG_20400 aldehyde dehydrogenase family protein from Sphingobium sp. SYK-6
36% identity, 81% coverage
- The Catabolic System of Acetovanillone and Acetosyringone in Sphingobium sp. Strain SYK-6 Useful for Upgrading Aromatic Compounds Obtained through Chemical Lignin Depolymerization
Higuchi, Applied and environmental microbiology 2022 (secret) - Roles of two glutathione S-transferases in the final step of the β-aryl ether cleavage pathway in Sphingobium sp. strain SYK-6
Higuchi, Scientific reports 2020 - “...LigE, and LigP, -etherases; LigG and LigQ, GSH-removing enzymes; HpvZ, HPV oxidase; ALDHs, aldehyde dehydrogenases; SLG_20400, vanilloyl acetaldehyde dehydrogenase. Abbreviations . GGE, guaiacylglycerol--guaiacyl ether; MPHPV, -(2-methoxyphenoxy)--hydroxypropiovanillone; GS-HPV, -glutathionyl--hydroxypropiovanillone; HPV, -hydroxypropiovanillone; GS , reduced glutathione; GSSG, oxidized glutathione. In this study, we identified the GS-HPV-converting GST genes...”
- Bacterial Catabolism of β-Hydroxypropiovanillone and β-Hydroxypropiosyringone Produced in the Reductive Cleavage of Arylglycerol-β-Aryl Ether in Lignin
Higuchi, Applied and environmental microbiology 2018 - “...analyses suggested that 36 multiple ALDH genes, including SLG_20400, contribute to the conversion of VAL. We 37 examined whether the genes encoding feruloyl-CoA...”
- “...370 SLG_07790, SLG_09510, SLG_11410, SLG_12800, SLG_18210, SLG_20400, 371 SLG_27910 (bzaA), SLG_27920 (bzaB), SLG_28150, SLG_31150, SLG_38120] were 372 used...”
Bcen_5677 aldehyde dehydrogenase from Burkholderia cenocepacia AU 1054
35% identity, 87% coverage
B0W47_16410 coniferyl aldehyde dehydrogenase from Komagataeibacter nataicola
34% identity, 91% coverage
- Complete genome sequence of the cellulose-producing strain Komagataeibacter nataicola RZS01
Zhang, Scientific reports 2017 - “...B0W47_01230, B0W47_02520, B0W47_10950 Glycerol dehydrogenase PQQ B0W47_01005, B0W47_01010 Alcohol dehydrogenase PQQ B0W47_13410 Aldehyde dehydrogenase PQQ B0W47_16410 2-Keto- d -gluconate dehydrogenase FAD B0W47_11030, B0W47_11035, B0W47_11040 Gluconate 2-dehydrogenase FAD B0W47_05395, B0W47_05400, B0W47_05405, B0W47_13405 Adaptation to extreme conditions K. nataicola RZS01 possesses the ability to tolerate low pH and...”
CCM_09155 fatty aldehyde dehydrogenase from Cordyceps militaris CM01
35% identity, 82% coverage
- Advancing Cordyceps militaris Industry: Gene Manipulation and Sustainable Biotechnological Strategies
Hu, Bioengineering (Basel, Switzerland) 2024 - “...transcriptome data of C. militaris 10 cultured under dark and light conditions, the CCM_06728 and CCM_09155 genes might be involved in the biosynthesis of carotenoids in C. militaris , and the absence of terpenoid synthase gene (Tns) in C. militaris led to a significant decrease in...”
- Light-Exposed Metabolic Responses of Cordyceps militaris through Transcriptome-Integrated Genome-Scale Modeling
Soommat, Biology 2024 - “...diphosphate (FPP) synthetase, were eventually responsible for enhanced carotenoid production, and rt_R0009 associated with the CCM_09155 gene encoding 4-apo-beta carotenal oxygenase (EC: 1.2.1.82) was involved in carotenoid biosynthesis. Moreover, several reactions in cordycepin biosynthesis were identified, such as cordycepin (CCM_04436 and CCM_04437) and the 3 amp...”
- Genome resequencing and transcriptome analysis reveal the molecular mechanism of albinism in Cordyceps militaris
Zhao, Frontiers in microbiology 2023 - “...FPKM values of 13 genes related to carotenoid biosynthesis including dioxygenase (CCM_06728), fatty aldehyde dehydrogenase (CCM_09155), geranylgeranyl pyrophosphate synthetase GGPPS (CCM_03697, CCM_03059, and CCM_06355), hydroxymethylglutaryl-CoA synthase (CCM_00310), farnesyl pyrophosphate synthetase (CCM_03203), 3-hydroxy-3-methylglutaryl-coenzyme A reductase (CCM_04994), acetyl-CoA acetyltransferase (CCM_05367 and CCM_07659), phosphomevalonate kinase (CCM_05380), mevalonate kinase (CCM_07937),...”
- “...expression in carotenoid biosynthesis and metabolism. (A) Heatmap analysis of dioxygenase (CCM_06728), fatty aldehyde dehydrogenase (CCM_09155), GGPP synthetase (CCM_03697, CCM_03059, and CCM_06355), hydroxymethylglutaryl-CoA synthase (CCM_00310), FPP synthetase (CCM_03203), 3-hydroxy-3-methylglutaryl-coenzyme A reductase (CCM_04994), acetyl-CoA acetyltransferase (CCM_05367), phosphomevalonate kinase (CCM_05380), acetyl-CoA acetyltransferase (CCM_07659), mevalonate kinase (CCM_07937), and diphosphomevalonate...”
- Cmcrf1, a Putative Zn2Cys6 Fungal Transcription Factor, Is Involved in Conidiation, Carotenoid Production, and Fruiting Body Development in Cordyceps militaris
He, Biology 2022 - “...genes ( CCM_00646 , CCM_08845 , CCM_01982 , CCM_04017 , CCM_03203 , CCM_06728 , and CCM_09155 ) by qRT-PCR. The expression levels of four genes ( CCM_01982 , CCM_03203 , CCM_06728 , and CCM_09155 ) were significantly down-regulated, while the expression levels of the other three...”
- Construction of Light-Responsive Gene Regulatory Network for Growth, Development and Secondary Metabolite Production in Cordyceps militaris
In-On, Biology 2022 - “...DEGs in this study (CCM_03697, CCM_03059, CCM_06355 geranylgeranyl diphosphate synthases, CCM_06728 carotenoid oxygenase 2 and CCM_09155 aldehyde dehydrogenase). Rather, it was identified that CCM_03203 FPP synthetase was up-regulated, while CCM_05579 geranylgeranyltransferase (GGTase) beta subunit was down-regulated. FPP synthetase catalyzes reactions that yield farnesyl pyrophosphate (FPP), a...”
- Biomass and Cordycepin Production by the Medicinal Mushroom Cordyceps militaris-A Review of Various Aspects and Recent Trends towards the Exploitation of a Valuable Fungus
Kontogiannatos, Journal of fungi (Basel, Switzerland) 2021 - “...differentially expressed DEGs between these two conditions; therefore, only two genes, i.e., CCM_06728 (CAO-2) and CCM_09155 (YLO-1), could be associated with the biosynthesis of carotenoids. Unexpectedly, the expression levels of these genes were not significantly different between mycelia exposed to light and darkness [ 84 ]....”
- Transcriptome Analysis of Cordyceps militaris Reveals Genes Associated With Carotenoid Synthesis and Identification of the Function of the Cmtns Gene
Lou, Frontiers in microbiology 2019 - “...Analysis To validate the quality of transcriptome data, five genes (CCM_04119, CCM_05246, CCM_06728, CCM_08263, and CCM_09155) were selected for qRT-PCR analysis using the elongation factor 1-alpha ( tef1 ) gene (GenBank: DQ070019) as the internal control gene ( Lian et al., 2014b ). Total RNA of...”
- “...pathway in the KEGG database, and the results showed that only the CCM_06728 (CAO-2) and CCM_09155 (YLO-1) genes were found to be involved in the biosynthesis of carotenoids ( Supplementary Figure S2 ). Unexpectedly, the expression levels of these two genes (CCM_06728 and CCM_09155) were not...”
WP_016502080 coniferyl aldehyde dehydrogenase from Pseudomonas sp. SDS3-8
36% identity, 90% coverage
- ALD5, PAD1, ATF1 and ATF2 facilitate the catabolism of coniferyl aldehyde, ferulic acid and p-coumaric acid in Saccharomyces cerevisiae
Adeboye, Scientific reports 2017 - “...of the ALD5, PAD1, ATF1, ATF2 and CALDH respectively are NP_010996, DAA12367, CAA99708, CAA97203 and WP_016502080 respectively. Selection criteria for genes of interest As, we have previously proposed a pathway for the conversion of coniferyl aldehyde, ferulic acid and p-coumaric acid 5 , we prospected for...”
LOC101491914, XP_004507095 aldehyde dehydrogenase family 3 member F1-like from Cicer arietinum
35% identity, 85% coverage
- Aldehyde Dehydrogenase 3 Is an Expanded Gene Family with Potential Adaptive Roles in Chickpea
Carmona-Molero, Plants (Basel, Switzerland) 2021 - “...count numbers, suggesting that they are expressed at very low levels in root tissues (LOC101497113, LOC101491914 and LOC101511819). Overall, the ALDH counts are highly correlated between non-inoculated and inoculated plants (R = 0.91). However, two genes were more abundant in a given condition: LOC101510843 ( CaALDH11A3...”
- “...7.08 CaALDH18B1 LOC101512568 Ca6 44,541,903 44,527,947 - XM_027335197 21 XP_027190998 759 82.38 4 6.82 CaALDH3F2 LOC101491914 Ca6 53,416,538 53,426,529 + XM_004507038 10 XP_004507095 488 54.56 1 9.22 CaALDH11A3 LOC101510843 Ca7 1,260,647 1,264,733 + XM_004507665 9 XP_004507722 496 52.81 1 6.53 CaALDH12A1 LOC101490107 Ca7 8,738,308 8,744,740 +...”
- “...XM_027335197 21 XP_027190998 759 82.38 4 6.82 CaALDH3F2 LOC101491914 Ca6 53,416,538 53,426,529 + XM_004507038 10 XP_004507095 488 54.56 1 9.22 CaALDH11A3 LOC101510843 Ca7 1,260,647 1,264,733 + XM_004507665 9 XP_004507722 496 52.81 1 6.53 CaALDH12A1 LOC101490107 Ca7 8,738,308 8,744,740 + XM_004508712 16 XP_004508769 553 61.30 1 6.17...”
SDRG_06419 hypothetical protein from Saprolegnia diclina VS20
35% identity, 83% coverage
Q583M9 Aldehyde dehydrogenase from Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
36% identity, 78% coverage
An01g09260 uncharacterized protein from Aspergillus niger
35% identity, 84% coverage
- The transcriptomic signature of RacA activation and inactivation provides new insights into the morphogenetic network of Aspergillus niger
Kwon, PloS one 2013 - “...Up/Down Closest S. cerevisiae ortholog (Phospho)lipid metabolism and signaling dehydrogenase involved in sphingosin 1-phosphate breakdown An01g09260 Hfd1 Lysophospholipase, synthesis of glycerophosphocholine An16g01880 plasma membrane flippase transporting sphingoid long chain bases An02g06440 Rsb1 glycerophosphocholine phosphodiesterase, synthesis of phosphocholine An18g03170 Gde1 lanosterol 14A-demethylase An11g02230 Erg11 C-14 sterol reductase,...”
- “...growth slows down basic cellular processes. In this context, it is interesting to note that An01g09260 predicted to break down sphingosin 1-phosphate (S1P) showed increased expression during apolar growth. S1P is a sphingolipid acting as second messenger in lower and higher eukaryotes regulating respiration, cell cycle...”
- Metabolic pathway reconstruction of eugenol to vanillin bioconversion in Aspergillus niger
Srivastava, Bioinformation 2010 - “...protein An09g01380 (gi|145241618|ref|XP_001393455.1 predicted as EhyB), hypothetical protein An15g01840 (gi|145250419|ref|XP_001396723.1 predicted as CalA), hypothetical protein An01g09260 (gi|145230075|ref|XP_001389346.1 predicted as CalB), hypothetical protein An14g05630 (gi|145249694|ref|XP_001401186.1 predicted as Fcs) and hypothetical protein An02g02820 (gi|145231906|ref|XP_001399422.1 predicted as Ech) predicted to be the pathways enzymes of target organism i.e., A....”
GRMZM2G155502 aldehyde dehydrogenase 3B1 from Zea mays
36% identity, 85% coverage
- Exogenous Serotonin (5-HT) Promotes Mesocotyl and Coleoptile Elongation in Maize Seedlings under Deep-Seeding Stress through Enhancing Auxin Accumulation and Inhibiting Lignin Formation
Zhao, International journal of molecular sciences 2023 - “..., GRMZM2G071021 , Zm00001d053904 , and Zm00001d053906 ) were upregulated, whereas another five genes ( GRMZM2G155502 , GRMZM2G103546 , GRMZM2G001898 , Zm00001D051754 , and Zm00001d038841 ) in the mesocotyl of W64A maize seedlings were downregulated at a 20 cm seeding depth [ 1 ]. These findings...”
- Aldehyde dehydrogenase (ALDH) superfamily in plants: gene nomenclature and comparative genomics
Brocker, Planta 2013 - “...100280692 ZmALDH3E1 NP_001147083.1 GRMZM2G169458 5 10 485 Jimenez-Lopez et al. 2010 ALDH3E2 100284774 ZmALDH3E2 NP_001151141.1 GRMZM2G155502 10 9 489 Jimenez-Lopez et al. 2010 ALDH3H1 100285809 ZmALDH3H1 NP_001152171.1 GRMZM2G103546 10 10 491 Jimenez-Lopez et al. 2010 ALDH3H2 100281700 ZmALDH3H2 NP_001148092.1 GRMZM2G060800 4 10 481 Jimenez-Lopez et al....”
LOC101497113, XP_004486968 aldehyde dehydrogenase family 3 member F1-like from Cicer arietinum
34% identity, 84% coverage
- Aldehyde Dehydrogenase 3 Is an Expanded Gene Family with Potential Adaptive Roles in Chickpea
Carmona-Molero, Plants (Basel, Switzerland) 2021 - “...ALDH count numbers, suggesting that they are expressed at very low levels in root tissues (LOC101497113, LOC101491914 and LOC101511819). Overall, the ALDH counts are highly correlated between non-inoculated and inoculated plants (R = 0.91). However, two genes were more abundant in a given condition: LOC101510843 (...”
- “...RNA ID Exons Protein ID Protein Length (aa) Molecular Weight Isoforms Number Isoelectric Point CaALDH3F1 LOC101497113 Ca1 11,135,019 11,130,555 - XM_004486911 10 XP_004486968 494 54.82 1 8.10 CaALDH22A1 LOC101512347 Ca1 17,180,053 17,171,549 - XM_004487701 14 XP_004487758 595 65.35 1 6.72 CaALDH7A1 LOC101513733 Ca1 23,039,421 23,046,624 +...”
- “...(aa) Molecular Weight Isoforms Number Isoelectric Point CaALDH3F1 LOC101497113 Ca1 11,135,019 11,130,555 - XM_004486911 10 XP_004486968 494 54.82 1 8.10 CaALDH22A1 LOC101512347 Ca1 17,180,053 17,171,549 - XM_004487701 14 XP_004487758 595 65.35 1 6.72 CaALDH7A1 LOC101513733 Ca1 23,039,421 23,046,624 + XM_012718791 15 XP_012574245 508 54.09 2 5.70...”
LOC21398387 aldehyde dehydrogenase family 3 member F1 from Morus notabilis
32% identity, 87% coverage
- Genome-Wide Identification of Candidate Genes Associated with Heat Stress in Mulberry (Morus alba L.)
Jin, Current issues in molecular biology 2023 - “...methylcrotonoyl-CoA carboxylase beta chain (LOC21410135), 2-oxoisovalerate dehydrogenase subunit beta 1 (LOC21388555), aldehyde dehydrogenase family 3 (LOC21398387), probable 3-hydroxybutyrate dehydrogenase (LOC21408668), branched-chain amino acid aminotransferase 1 (LOC21390509), isovaleryl-CoA dehydrogenase (LOC21397545), methylcrotonoyl-CoA carboxylase subunit alpha (LOC21385626), probable enoyl-CoA hydratase 1 (LOC21392597), aldehyde dehydrogenase family 3 (LOC21396538) and alanine--glyoxylate...”
LOC100185488 LOW QUALITY PROTEIN: aldehyde dehydrogenase, dimeric NADP-preferring-like from Ciona intestinalis
35% identity, 93% coverage
- ceRNA Network Regulation of TGF-β, WNT, FOXO, Hedgehog Pathways in the Pharynx of Ciona robusta
Vizzini, International journal of molecular sciences 2021 - “...(LOC100182579), transcript variant X1 XM_002128752.5 99.87% 11 ENSCING00000022279 Chromosome 3: 892,375893,636 Aldehyde dehydrogenase, dimeric NADP-preferring-like (LOC100185488) XM_009859599.3 99.76% 3 ENSCING00000019638 Chromosome 13: 1,743,1721,744,608 poly [ADP-ribose] polymerase 2 (LOC100178364) XM_002128271.4 100.00% 13 ENSCING00000009399 Chromosome 3: 3,711,8733,713,223 major facilitator superfamily domain-containing protein 10-like (LOC100182178) XM_009859732.3 99.85% 3 ENSCING00000006160...”
PP_5120 coniferyl aldehyde dehydrogenase from Pseudomonas putida KT2440
PP5120 conifer aldehyde dehydrogenase, putative from Pseudomonas putida KT2440
36% identity, 90% coverage
- Metabolic engineering of Pseudomonas putida for production of vanillylamine from lignin-derived substrates
Manfrão-Netto, Microbial biotechnology 2021 - “...increase the efficiency of vanillin biotransformation. In a previous proteomics study, the aldehyde dehydrogenases PP_3151, PP_5120 and PP_5258 showed an increased abundance in response to vanillin, representing possible targets to abolish the oxidation of vanillin into vanillic acid (Simon etal ., 2014 ). Wholecell bioconversion of...”
- A bacterial aromatic aldehyde dehydrogenase critical for the efficient catabolism of syringaldehyde
Kamimura, Scientific reports 2017 - “...In contrast, proteomic analyses indicated that the production of other ALDHs, PP_0545, PP_1948, PP_2680, PP_3151, PP_5120, and PP_5258, increased in response to VN. Additional disruption of PP_0545, PP_1948, and PP_2680 in vdh mutant enhanced productivity of VN from ferulate 23 . Another example of the involvement...”
- New transposon tools tailored for metabolic engineering of gram-negative microbial cell factories
Martínez-García, Frontiers in bioengineering and biotechnology 2014 - “...+ pykF , pyruvate kinase KT-K2-G2 ME-O 3,749,626 PP3313 Heat shock protein KT-K2-G3 ME-O 5,842,545 PP5120 + Conifer aldehyde dehydrogenase KT-K2-G4 ME-O 1,373,720 PP1199 Hypothetical protein KT-K2-S1 ME-O 2,904,080 PP2556 Chromate transporter KT-K2-S2 ME-O 5,347,381 PP4703 + Hypothetical protein KT-K2-S3 ME-O 1,542,387 PP1353 + Mechanosensitive ion...”
CARD_GIBF5 / F6IBC7 Beta-apo-4'-carotenal oxygenase; Beta-apo-4'-carotenal dehydrogenase; EC 1.2.1.82 from Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831) (Bakanae and foot rot disease fungus) (Fusarium fujikuroi) (see paper)
F6IBC7 beta-apo-4'-carotenal oxygenase (EC 1.2.1.82) from Fusarium fujikuroi (see paper)
FFUJ_07503 related to aldehyde dehydrogenase from Fusarium fujikuroi IMI 58289
35% identity, 80% coverage
- function: Beta-apo-4'-carotenal oxygenase involved in the last step of synthesis of neurosporaxanthin, a carboxylic apocarotenoid acting as an essential protective pigments and leading to orange pigmentation (PubMed:21749649). Converts the aldehyde beta-apo-4'-carotenal into neurosporaxanthin (PubMed:21749649). Is also able to use shorter apocarotenals as substrates (such as beta-apo-8'-carotenal (C30), beta- apo-10'-carotenal (C27), or the acyclic apocarotenal apo-8'-lycopenal (C30)), indicating wide substrate specificity (PubMed:21749649). Neurosporaxanthin is synthesized from geranyl-geranyl pyrophosphate (GGPP) through several enzymatic activities. Phytoene synthase activity performed by the bifunctional enzyme carAR first produces phytoene from geranyl-geranyl pyrophosphate (GGPP). The phytoene dehydrogenase carB then introduces 4 desaturations to lead to lycopene which is substrate of the carotene cyclase activity of carAR that leads to the production of gamma-carotene. CarB then performs a 5th desaturation reaction to yield torulene. Torulene is the substrate of the dioxidase carT that breaks the molecule, removing five carbon atoms to yield beta-apo-4'- carotenal, whereas the aldehyde dehydrogenase carD mediates the last step by converting beta-apo-4'-carotenal into neurosporaxanthin (Probable).
catalytic activity: 4'-apo-beta-carotenal + NAD(+) + H2O = neurosporaxanthin + NADH + 2 H(+) (RHEA:31515) - The carP lncRNA Is a carS-Related Regulatory Element with Broad Effects on the Fusarium fujikuroi Transcriptome
Pardo-Medina, Non-coding RNA 2021 - “...FFUJ_11803 ); 4: carO ( FFUJ_11804 ); 5: carT ( FFUJ_07962 ); 6: carD ( FFUJ_07503 ); 7: ggs1 ( FFUJ_07352 ); 8: carS ( FFUJ_08714 ). Figure 2 Effect of light in the transcriptomes of the wild type and the carP mutant. Venn diagrams show...”
J3QRD1 Aldehyde dehydrogenase family 3 member A2 from Homo sapiens
40% identity, 84% coverage
- Proteomics analyses for the global proteins in the brain tissues of different human prion diseases
Shi, Molecular & cellular proteomics : MCP 2015 - “...P01860, P01876, P01861, P01857, P01859, A9R9N8, P01877 8 Chloroalkane and chloroalkene degradation 0.0169 5 P30837, J3QRD1, P05091, E5RFU2, P11766 9 Fc gamma R-mediated phagocytosis 0.0212 24 Q9Y6W5, P59998, O15145, B3KR49, Q05193, E9PCV4, P07948, O00401, P01860, P01876, G3V1A4, P01861, P01857, P49418, P01859, G3V5P4, F5H1A8, P29966, P46109, P49006,...”
- “...G3V0I5, Q9Y6M9, Q9P0J0, O95299, O75251, G5E9P1, P56556, O95168 5 beta-Alanine metabolism 0.0483 13 Q99259, B4DE40, J3QRD1, P49419, P80404, P19623, B4DJE7, O95822, P40939, P30837, P30084, Q16853, Q6NVY1 G114V vs. Ctrl 1 Ribosome 0.0010 46 P47914, P62851, P05387, P62979, P62277, P39019, P05386, P62753, P30050, P46777, J3QS96, P25398, P35268,...”
- Down-regulation of Ras-related protein Rab 5C-dependent endocytosis and glycolysis in cisplatin-resistant ovarian cancer cell lines.
Jin, Molecular & cellular proteomics : MCP 2014
LOC101511819, XP_012573731 LOW QUALITY PROTEIN: aldehyde dehydrogenase family 3 member F1-like from Cicer arietinum
34% identity, 85% coverage
- Aldehyde Dehydrogenase 3 Is an Expanded Gene Family with Potential Adaptive Roles in Chickpea
Carmona-Molero, Plants (Basel, Switzerland) 2021 - “...suggesting that they are expressed at very low levels in root tissues (LOC101497113, LOC101491914 and LOC101511819). Overall, the ALDH counts are highly correlated between non-inoculated and inoculated plants (R = 0.91). However, two genes were more abundant in a given condition: LOC101510843 ( CaALDH11A3 ) was...”
- “...regulation of most of the ALDH candidates seems to be induced in our material, the LOC101511819 ( CaALDH3F3 ) is clearly upregulated in infected roots of the susceptible and resistant NILs at 24 and 72 hpi, respectively ( Figure 5 ). This is interesting because the...”
- “...XM_004508796 12 XP_004508853 536 58.58 3 7.57 CaALDH3F3 LOC101511819 Ca7 14,455,263 14,450,584 - XM_012718277 10 XP_012573731 488 54.13 1 7.99 CaALDH2B7 LOC101492709 Ca7 21,404,965 21,399,791 - XM_004509777 11 XP_004509834 539 58.04 1 6.58 CaALDH2C6 LOC101513875 Ca8 14,992,271 14,983,690 - XM_012719313 9 XP_012574767 498 44.10 1 5.55...”
VCA1067 aldehyde dehydrogenase from Vibrio cholerae O1 biovar eltor str. N16961
34% identity, 88% coverage
- Mining regulatory 5'UTRs from cDNA deep sequencing datasets
Livny, Nucleic acids research 2010 - “...46* VC2701 Thiol:disulfide interchange protein precursor Electron transport, protein thiol-disulfide exchange, cytochrome complex assembly 47 VCA1067 Aldehyde dehydrogenase Fermentation 48 VC0374 Glucose-6-phosphate isomerase Glycolysis 49 VCA0843 Glyceraldehyde-3-phosphate dehydrogenase Glycolysis 50 VC0986 Adenylate kinase Nucleobase, nucleoside and nucleotide interconversion 51 VCA0623 Transaldolase B Pentose-phosphate shunt 52 VCA0870...”
5nnoA / C9ZQX6 Structure of tbaldh3 complexed with NAD and an3057 aldehyde (see paper)
36% identity, 87% coverage
- Ligands: nicotinamide-adenine-dinucleotide; 4-[(1-oxidanyl-3~{h}-2,1-benzoxaborol-5-yl)oxy]benzaldehyde (5nnoA)
C9JMC5 Aldehyde dehydrogenase, dimeric NADP-preferring (Fragment) from Homo sapiens
37% identity, 84% coverage
- Salivary proteomics in bisphosphonate-related osteonecrosis of the jaw
Thumbigere-Math, Oral diseases 2015 - “...3 ATP synthase subunit alpha, mitochondrial 1.547 1.35E-04 P05546 4 Heparin cofactor 2 1.502 8.06E-09 C9JMC5 4 Aldehyde dehydrogenase 3 family, member A1 2.310 3.11E-15 P09211 2 Glutathione S-transferase P 2.123 5.46E-07 O60218 6 Aldo-keto reductase family 1 member B10 1.850 2.41E-09 P55786 4 Puromycin-sensitive aminopeptidase...”
- Quantitative proteomic analysis of the effect of fluoride on the acquired enamel pellicle.
Siqueira, PloS one 2012 - “...6-phosphogluconate dehydrogenase, decarboxylating Q5SX91 GDP dissociation inhibitor 2 (Fragment) Q5T8F0 Cathepsin L1 C9J8F3 Uncharacterized protein C9JMC5 Uncharacterized protein E7EQL7 Uncharacterized protein E9PFF2 Transketolase F5H0N0 Actin, gamma 1 F5H8B6 Proteinase 3 10.1371/journal.pone.0042204.g003 Figure 3 Venn diagram of AEP proteins identified in each group and across groups. Relative...”
MAV_5147 fatty aldehyde dehydrogenase from Mycobacterium avium 104
35% identity, 92% coverage
AL3I1_ARATH / Q8W033 Aldehyde dehydrogenase family 3 member I1, chloroplastic; AtALDH3; Ath-ALDH3; EC 1.2.1.3 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
Q8W033 glycolaldehyde dehydrogenase (EC 1.2.1.21); aldehyde dehydrogenase (NAD+) (EC 1.2.1.3) from Arabidopsis thaliana (see 2 papers)
NP_567962 aldehyde dehydrogenase 3I1 from Arabidopsis thaliana
AT4G34240 ALDH3I1 (ALDEHYDE DEHYDROGENASE 3I1; 3-chloroallyl aldehyde dehydrogenase/ aldehyde dehydrogenase (NAD) from Arabidopsis thaliana
35% identity, 76% coverage
- function: Involved in oxidative stress tolerance by detoxifying reactive aldehydes derived from lipid peroxidation. Medium- to long- chain saturated aldehydes are preferred substrates, while the short- chain aldehyde propanal is a weak substrate. Can use both NAD(+) and NADP(+), but the coenzyme preference is substrate dependent.
catalytic activity: an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+) (RHEA:16185)
subunit: Homodimer and homomultimer. - The phosphoproteome in regenerating protoplasts from Physcomitrella patens protonemata shows changes paralleling postembryonic development in higher plants
Wang, Journal of experimental botany 2014 - “...DQIGS#SVEST#IAK C13 40.1 8.87 NP_196027 Short-chain dehydrogenase/reductase (SDR) family protein Unknown FNHS#HT#PVCVITGAT#SGLGK C14 60.2 8.74 Q8W033 Aldehyde dehydrogenase family 3 member I1 Chloroplast LFS#EYLDNTT#IR C15 79.9 6.12 NP_566041 Transketolase, putative Chloroplast S#IGIDT#FGASAPAGK C16 45.8 5.12 NP_196694 Monooxygenase family protein Membrane S#SEPPVGSPT#GAGLGLDPQAR C17 52.3 5.6 Q9C7Z9 Serine...”
- Aldehyde Dehydrogenases Function in the Homeostasis of Pyridine Nucleotides in Arabidopsis thaliana.
Missihoun, Scientific reports 2018 - GeneRIF: a role of ALDHs as major contributors to the homeostasis of pyridine nucleotides in plants
- The role of Arabidopsis aldehyde dehydrogenase genes in response to high temperature and stress combinations.
Zhao, Journal of experimental botany 2017 - GeneRIF: ALDH3I1 and ALDH7B4 are strongly induced by heat stress. Higher levels of ALDH7B4 accumulated in response to dehydration-heat, heat-salt and wounding-heat combination stress than in response to single stressors.
- Over-expression of different aldehyde dehydrogenase genes in Arabidopsis thaliana confers tolerance to abiotic stress and protects plants against lipid peroxidation and oxidative stress.
Kotchoni, Plant, cell & environment 2006 (PubMed)- GeneRIF: Constitutive or stress-inducible expression of ALDH3I1 confers tolerance to osmotic and oxidative stress.
- Decoding Arabidopsis thaliana CPK/SnRK Superfamily Kinase Client Signaling Networks Using Peptide Library and Mass Spectrometry
Ahsan, Plants (Basel, Switzerland) 2024 - “...factor 1 (At2g38280), magnesium chelatase I2 (At5g45930), cell division cycle 48B (At3g53230), aldehyde dehydrogenase 3 (At4g34240), XAP5 circadian timekeeper (At2g21150), and POL-like 5 (At1g07630), were identified as clients for each of the kinases tested ( Figure 2 A). Overlapping client specificity among the kinase subfamilies was...”
- “...reductase 2 (At1g37130), CRKs (A3g49370, At1g49580), calcium-binding EF-hand family proteins (At1g21630, At1g20760), aldehyde dehydrogenase 3 (At4g34240), and BRI1 suppressors 1 like proteins (At4g03080, At1g08420). Together with these proteins, a number of transporters, including PIP2.8 (At2g16850), MSL10 (At5g12080), Metal transport protein 5 (At3g12100), Transmembrane amino acid transporter...”
- Selection and validation of reference genes for qRT-PCR normalization in dayflower (Commelina communis) based on the transcriptome profiling
Yang, BMC plant biology 2024 - “...phosphatase 2A-3 TCTCGAAGACGAAGAGAAGAGA /CACTTGAGTTCTGGCGAGTT 126 78 AT1G03980 PCS1 phytochelatin synthase 1 GTTCGGGAGACTGAACTGTATAA /CCGGGTTTCTCTAAAGAAGATGA 93 83 AT4G34240 ALDH113 aldehyde dehydrogenase 3I1 GAGGCGTTTAGAACTCGAAAGA /CGCATCCATGATCTCCTTCTC 105 81 AT2G28390 SAND SAND family protein AGATGTGCCTGTTGATTCTTC /CTGGACCACCAATGCTTACA 110 83 AT1G64470 UBQ3 Ubiquitin-like superfamily protein GCCTAGCAATCTGTTGTTTCAC /CGTTCTCCGTCTCGTCATTC 131 80 AT5G13080 WRKY WRKY DNA-binding...”
- Trans-cinnamaldehyde-related overproduction of benzoic acid and oxidative stress on Arabidopsis thaliana
López-González, Frontiers in plant science 2023 - “...AT3G24503 TGATATTGACAAAGCCGCCG/AGGATCACCAACGGTCCAAT 160 2.001 ALDH3F1 AT4G36250 TCGCGCCTACTCTGATTGAT/AGACGATGGAAGCTTGGACA 159 2.001 ALDH3H1 AT1G44170 TTTGGCCCTCTCCTTCCAAT/TGACTACTATGCCTCCAGCG 160 1.995 ALDH3I1 AT4G34240 TCACTGGTGGAGCAAGAGTT/GATCCTCCTAGCAGCCACTT 140 1.995 ALDH7B4 AT1G54100 TCAGAACGCCCTAACCACAT/CACCACACATGGCCGTAAAA 250 2.001 ALDH11A3 AT2G24270 CCGATAGCTTCCCCGGTAAT/GGAGGTTTGAGGACAAGGGA 163 1.995 ALDH22A1 AT3G66658 CTTTCTGAGGGCGAACGATG/CACCAAGGGGATGGAACTCT 97 2.000 Gene expression analyses were performed following the Minimum Information for publication of...”
- Bioenergetics of pollen tube growth in Arabidopsis thaliana revealed by ratiometric genetically encoded biosensors
Liu, Nature communications 2022 - “...Information Resource ( https://www.arabidopsis.org ) under the following accession numbers: NTT1 (At1g80300), NTT2 (At1g15500), ALDH3I1 (At4g34240), ALDH10A8 (At1g74920), ALDH2B7 (At1g23800), ALDH7B4 (At1g54100), FtsZ1 (At5g55280). Reporting summary Further information on research design is available in the Nature Portfolio Reporting Summary linked to this article. Supplementary information Supplementary...”
- Stress-related expression of the chloroplast EGY3 pseudoprotease and its possible impact on chloroplasts' proteome composition
Adamiec, Frontiers in plant science 2022 - “...the comparative C T method was used with the aldehyde dehydrogenase 3 ( ALDH3 , At4g34240 ) (for heat stress variant) and the cyclophilin 5 ( CYP5 , At2g29960 ; for high light stress) as the endogenous control. The amount of target normalized to an endogenous...”
- Iron insufficiency in floral buds impairs pollen development by disrupting tapetum function
Huang, The Plant journal : for cell and molecular biology 2021 - “...an alcohol dehydrogenase ( ADH , AT5G42250), an aldehyde dehydrogenase ( ALDH3 / ALDH3l1 , AT4G34240), acylCoA oxidase ( ACX2 , AT5G65110), and a 3ketoacylCoA thiolase ( KAT2 , AT2G33150), were involved in the fatty acid degradation pathway. ADH and ALDH are critical enzymes for generating...”
- “...fatty alcohol biosynthesis, which might facilitate fatty aciddegradation. The differential expression of MS2 , AT5G42250, AT4G34240, AT5G65110, AT5G48880, and AT2G33150 was confirmed by qPCR (Figure 4e ). The downregulation of genes involved in phenylpropanoid biosynthesis and upregulation of genes linked to fatty acid degradation suggests a...”
- Nitric oxide deficiency decreases C-repeat binding factor-dependent and -independent induction of cold acclimation
Costa-Broseta, Journal of experimental botany 2019 - “...A_84_P807853 2.580678 n.s.d. AT2G36530 ENO2 , LOS2 A_84_P23380 2.5109425 n.s.d. AT5G01540 LECRKA4.1 A_84_P11990 n.s.d. 1.9472115 AT4G34240 ALDH3 , ALDH3I1 A_84_P809296 n.s.d. 1.8705412 AT2G05520 ATGRP3 A_84_P531660 n.s.d. 1.4853065 AT4G21670 ATCPL1 , CPL1 , FRY2 A_84_P20725 1.7062953 n.s.d. AT5G63980 ALX8 , ATSAL1 , FRY1 A_84_P23165 1.6769094 n.s.d. AT3G50500...”
- Aldehyde Dehydrogenases Function in the Homeostasis of Pyridine Nucleotides in Arabidopsis thaliana
Missihoun, Scientific reports 2018 - “...KO6 (SALK_143309) for ALDH7B4 ( At1g54100 ) and KO62 (nos. 16843) 46 for ALDH3I1 ( At4g34240 ) were previously described 7 . Similarly, the single mutant KO69 (nos. 22184) 46 for ALDH3H1 ( At1g44170 ) was described and referred as 3h1-B in Missihoun et al ....”
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TTHERM_00530250 aldehyde dehydrogenase family protein from Tetrahymena thermophila SB210
36% identity, 85% coverage
- Mismatch Repair Protein Msh6Tt Is Necessary for Nuclear Division and Gametogenesis in Tetrahymena thermophila
Wang, International journal of molecular sciences 2023 - “...transglycosylase activity; and TTHERM_00418280, a metalloendopeptidase, is involved in proteolysis. TTHERM_00586710, TTHERM_00016060, TTHERM_00151470, TTHERM_00622710, and TTHERM_00530250 are proteins with oxidoreductase activity that are involved in redox processes. TTHERM_00849320 and TTHERM_00825210_RAB1C are factors involved in signaling regulated by small GTPases ( Figure 6 A). Furthermore, proteinprotein docking...”
LOC112001970 LOW QUALITY PROTEIN: aldehyde dehydrogenase family 3 member F1 from Quercus suber
33% identity, 85% coverage
- Transcriptomic and physiological responses of Quercus acutissima and Quercus palustris to drought stress and rewatering
Kim, Frontiers in plant science 2024 - “...whereas Q. palustris showed differential expression of genes encoding aldehyde dehydrogenase family 3 member F1-like (LOC112001970, LOC112010329, LOC112010330, LOC112010332, and LOC112010331), fructose-1,6-bisphosphatase, cytosolic protein (LOC112005255), alcohol dehydrogenase-like 2 isoform X1 (LOC112023924), alcohol dehydrogenase-like 2 (LOC112023922), which were significantly downregulated in both C vs. D comparisons. Downregulated...”
- “...state compared with that in the control. In Q. palustris , the glycolysis pathway-related genes, LOC112001970 and LOC112005255, were downregulated during drought, and showed partial recovery at R6d, indicating a tendency to remain downregulated compared with that in the control. LOC112020169 and LOC112020346 in the sucrose...”
Q6CGN3 Aldehyde dehydrogenase from Yarrowia lipolytica (strain CLIB 122 / E 150)
33% identity, 79% coverage
MT0155 aldehyde dehydrogenase, class 3 from Mycobacterium tuberculosis CDC1551
38% identity, 86% coverage
AL3B2_HUMAN / P48448 Aldehyde dehydrogenase family 3 member B2; ALDH3B2; Aldehyde dehydrogenase 8; Long-chain fatty aldehyde dehydrogenase; EC 1.2.1.3; EC 1.2.1.48 from Homo sapiens (Human) (see 2 papers)
NP_001026786 aldehyde dehydrogenase family 3 member B2 isoform a from Homo sapiens
39% identity, 76% coverage
- function: Oxidizes medium and long chain fatty aldehydes in lipid droplets into non-toxic fatty acids.
catalytic activity: an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+) (RHEA:16185)
catalytic activity: a long-chain fatty aldehyde + NAD(+) + H2O = a long-chain fatty acid + NADH + 2 H(+) (RHEA:10652)
catalytic activity: a medium-chain fatty aldehyde + NAD(+) + H2O = a medium-chain fatty acid + NADH + 2 H(+) (RHEA:69763)
catalytic activity: hexadecanoate + NADH + 2 H(+) = hexadecanal + NAD(+) + H2O (RHEA:33739)
catalytic activity: octanal + NAD(+) + H2O = octanoate + NADH + 2 H(+) (RHEA:44100) - Aldehyde dehydrogenase 3B2 promotes the proliferation and invasion of cholangiocarcinoma by increasing Integrin Beta 1 expression.
Wang, Cell death & disease 2021 - GeneRIF: Aldehyde dehydrogenase 3B2 promotes the proliferation and invasion of cholangiocarcinoma by increasing Integrin Beta 1 expression.
- Detection of ALDH3B2 in Human Placenta.
Michorowska, International journal of molecular sciences 2019 - GeneRIF: Despite premature stop codon in DNA and mRNA sequences, full-length ALDH3B2 was found. It can be formed as a result of premature stop codon readthrough, complex phenomenon enabling stop codon circumvention.
- New genetic associations detected in a host response study to hepatitis B vaccine.
Davila, Genes and immunity 2010 (PubMed)- GeneRIF: Observational study of gene-disease association. (HuGE Navigator)
- Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.
Saito, Journal of human genetics 2009 (PubMed)- GeneRIF: Observational study of gene-disease association. (HuGE Navigator)
- A crucial active site network of titratable residues guides catalysis and NAD<sup>+</sup> binding in human succinic semialdehyde dehydrogenase
Cesaro, Protein science : a publication of the Protein Society 2025 (no snippet) - Proteomic analysis of s-acylated proteins in human retinal pigment epithelial cells and the role of palmitoylation of Niemann-Pick type C1 protein in cholesterol transport
Li, Frontiers in aging neuroscience 2022 - “...member B2 OS = Homo sapiens GN = ALDH3B2 PE = 2 SV = 3 P48448 ALDH3B2 NPC * YVDDNC * DPQTVANR Aryl hydrocarbon receptor nuclear translocator 2 OS = Homo sapiens GN = ARNT2 PE = 1 SV = 2 Q9HBZ2 ARNT2 EQLC * TSENSMTGRILDLK...”
- Host-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles
Zhang, PLoS pathogens 2018 - “...H . sapiens ( Hs ALDH3A1, P30838;; Hs ALDH3A2, P51648;; Hs ALDH3B1, P43353;; Hs ALDH3B2, P48448). Secondary structure elements are indicated for Tb ALDH3A2 (colored by domain: blue, catalytic domain; red, NAD-binding domain; green, oligomerisation domain) and Hs ALDH3A2 (colored in grey, from pdb 4QGK). The...”
- Post-translational modifications of mitochondrial aldehyde dehydrogenase and biomedical implications.
Song, Journal of proteomics 2011 - “...PDYVLCSP 236 P43353 ALDH3B2 135 WFC Y FNA G QT C V A PDYVLCSP 155 P48448 ALDH4A1 320 RSA F EYG G QK C S A CSRLYVPH 340 P30038 ALDH5A1 312 ASK F RNT G QT C VCSNQFLVQR 332 P51649 ALDH6A1 289 GAA F GAA G...”
P96824 Aldehyde dehydrogenase from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
NP_214661 aldehyde dehydrogenase from Mycobacterium tuberculosis H37Rv
Rv0147 PROBABLE ALDEHYDE DEHYDROGENASE (NAD+) DEPENDENT from Mycobacterium tuberculosis H37Rv
38% identity, 83% coverage
- The unfoldase ClpC1 of Mycobacterium tuberculosis regulates the expression of a distinct subset of proteins having intrinsically disordered termini
Lunge, The Journal of biological chemistry 2020 (secret) - Cellular immune response in MDR-TB patients to different protein expression of MDR and susceptible Mycobacterium tuberculosis: Rv0147, a novel MDR-TB biomarker.
Hadizadeh, Immunologic research 2018 (PubMed)- GeneRIF: these results suggest that the purified protein, Rv0147, may stimulate Th1 type protective cytokine response in multidrug resistant tuberculosis patients but not in normal subjects
- Shotgun proteomic profiling of dormant, 'non-culturable' Mycobacterium tuberculosis
Nikitushkin, PloS one 2022 - “...was detected experimentally for M . smegmatis [ 55 ]). However, functioning aldehyde dehydrogenases ( Rv0147 , Rv2858c ) or glyoxylase ( Rv0577 ) detoxify these intermediates, ultimately to lactate. The further transformation of forming lactate by a quinone-dependent lactate dehydrogenase finally supplies the cells with...”
- Proteomics in Biomarker Discovery for Tuberculosis: Current Status and Future Perspectives
Guo, Frontiers in microbiology 2022 - “...2D-PAGE and MALDI-TOF/TOF MS Fu et al. (2012) Two isolated Mtb strains Rv0443, Rv0379, and Rv0147 Not available 2D-PAGE and MS Hadizadeh Tasbiti et al. (2021) Total 285 urine samples miR-625-3p, mannose-binding lectin 2, and inter--trypsin inhibitor H4 85.87% sensitivity and 87.50% specificity 2D-PAGE and MALDI-TOF/TOF...”
- “...expression and protein abundance in MDR Mycobacterium tuberculosis : novel protein candidates, Rv0443, Rv0379 and Rv0147 as TB potential diagnostic or therapeutic targets. Biotechnol. Rep. (Amst) 30 : e00641 . 10.1016/j.btre.2021.e00641 34189062 HaileMariam M. Eguez R. V. Singh H. Bekele S. Ameni G. Pieper R. (...”
- Comparing mRNA expression and protein abundance in MDR Mycobacterium tuberculosis: Novel protein candidates, Rv0443, Rv0379 and Rv0147 as TB potential diagnostic or therapeutic targets
Hadizadeh, Biotechnology reports (Amsterdam, Netherlands) 2021 - “...expression and protein abundance in MDR Mycobacterium tuberculosis : Novel protein candidates, Rv0443, Rv0379 and Rv0147 as TB potential diagnostic or therapeutic targets Hadizadeh Tasbiti Alireza hadi@pasteur.ac.ir a b Yari Shamsi sh_yari@pasteur.ac.ir a b * Siadat Seyed Davar siadat@pasteur.ac.ir a b Karimipoor Morteza mortezakarimi@pasteur.ac.ir c Badmasti...”
- “...proteins were made by the IEDB server. The result shows at least six protein spots (Rv0147, Rv3597c, Rv0379, Rv3699, Rv1392 and Rv0443) were differentially expressed in MDRTB isolates. However, difference in mRNA gene expression was not found in the six mRNA genes. 2DE-Western blot procedures indicated...”
- A Cas12a-based CRISPR interference system for multigene regulation in mycobacteria
Fleck, The Journal of biological chemistry 2021 - “...designed an array targeting the genes pknH , fadD2 , amiC , luxD , and rv0147 with two spacers for each genethe 5g array. To detect knockdown of all targeted genes and determine the efficiency of multigene knockdown, we analyzed the knockdown strains by qRT-PCR. All...”
- Protein-protein interaction of Rv0148 with Htdy and its predicted role towards drug resistance in Mycobacterium tuberculosis
Bhargavi, BMC microbiology 2020 - “...Rv2499c Rv2242 Htdx hatB fabD Rv0130 Rv3797 FadE9 fadE25 fadE10 fadE8 fadE20 FadE12 fadA FadA3 Rv0147 accD4 Rv3548c kasB Rv2228c mutT1 accD2 echA7 accD3 fadE13 Fig. 9 Interactome showing 220 genes interacting with Rv0148 Differential expression of htdy The interactome analysis predicted that htdy is also...”
- “...10 interacting partners such as Rv3538, Rv0149, mbtB , fas , fadB , aacA2 , Rv0147, Rv2228c, muT1 and htdy thus confirming our analysis. The predicted Htdy as an interacting partner of Rv0148 was further confirmed through far WB and pull-down assays. We generated gene knockout...”
- Cellular immune response in MDR-TB patients to different protein expression of MDR and susceptible Mycobacterium tuberculosis: Rv0147, a novel MDR-TB biomarker
Hadizadeh, Immunologic research 2018 (PubMed)- “...protein expression of MDR and susceptible Mycobacterium tuberculosis: Rv0147, a novel MDR-TB biomarker Alireza Hadizadeh Tasbiti 1 & Shamsi Yari 1 & Seyed Davar...”
- “...were stimulated by 55KDa protein fractions (Rv0147). The purified proteins identified by proteomic techniques (two-dimensional gel electrophoresis, mass...”
- T cell cytokine responses in peripheral blood mononuclear cells from patients with multidrug-resistant tuberculosis following stimulation with proteins purified from Mycobacterium tuberculosis MDR clinical isolates
Hadizadeh, International journal of mycobacteriology 2016 (PubMed)- “...(MDR)-TB patients against M. tuberculosis-purified proteins (Rv0147) as compared with healthy subjects.MethodsProteins were extracted by Triton X-114...”
- “...by stimulation with 10 g/mL of the protein candidate (Rv0147) for 72h. Culture supernatants were assayed for interleukin (IL)-10 and interferon (IFN)- by...”
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PMT9312_0337 putative aldehyde dehydrogenase from Prochlorococcus marinus str. MIT 9312
32% identity, 88% coverage
- Bioinformatic evaluation of L-arginine catabolic pathways in 24 cyanobacteria and transcriptional analysis of genes encoding enzymes of L-arginine catabolism in the cyanobacterium Synechocystis sp. PCC 6803
Schriek, BMC genomics 2007 - “...P9211_09067 n.d P9211_03592 n.d P9211_07012 Prochlorococcus marinus MIT 9312 PMT9312_1095, PMT9312_0046 PMT9312_1779 n.d PMT9312_0615 n.d PMT9312_0337 Prochlorococcus marinus MIT 9313 PMT1066, PMT2150 PMT2214 n.d PMT0395 n.d PMT0191 Prochlorococcus marinus MED 4 PMM1084, PMM0045 PMM1686 n.d PMM0615 n.d PMM1215, PMM0331 Prochlorococcus marinus NATL 2A PMN2A_0665, PMN2A_1378 PMN2A_1287...”
- “...marinus str. MIT 9211 P9211_09067 P9211_02002, P9211_10217 P9211_07012 Prochlorococcus marinus MIT 9312 PMT9312_1779 PMT9312_1397, PMT9312_1565 PMT9312_0337 Prochlorococcus marinus MIT 9313 PMT2214 PMT0331, PMT1493 PMT0191 Prochlorococcus marinus MED 4 PMM1686 PMM1301, PMM1472 PMM0331 Prochlorococcus marinus NATL 2A PMN2A_1287 PMN2A_0867, PMN2A_1003 PMN2A_1709 Synechococcus sp. CC 9605 Syncc9605_1082, Syncc9605_2591...”
ABO_0087 aldehyde dehydrogenase from Alcanivorax borkumensis SK2
34% identity, 89% coverage
- Differential protein expression during growth on linear versus branched alkanes in the obligate marine hydrocarbon-degrading bacterium Alcanivorax borkumensis SK2T
Gregson, Environmental microbiology 2019 - “...pristanol to pristanal. No aldehyde dehydrogenase was significantly differentially expressed during growth on pristane, but ABO_0087 was expressed on all substrates tested. The combination of these enzymes makes up a complete pathway for the terminal oxidation of branched alkanes (Fig. 3 B). Figure 3 Normalized spectral...”
- “...acid no aldehyde dehydrogenases were significantly differentially expressed during growth on pristane. An aldehyde dehydrogenase (ABO_0087) was expressed on all substrates tested meaning it may be constitutively expressed. Also, catalysis of sequential oxidation reactions is usual in cytochrome P450 reactions particularly with xenobiotics (Guengerich et al.,...”
XP_011394900 aldehyde dehydrogenase, variant from Neurospora crassa OR74A
34% identity, 83% coverage
Q6CG32 Aldehyde dehydrogenase from Yarrowia lipolytica (strain CLIB 122 / E 150)
34% identity, 80% coverage
YLO-1 / Q870P2 apo-4'-lycopenal dehydrogenase (EC 1.2.1.82) from Neurospora crassa (see paper)
CARD_NEUCR / Q1K615 Beta-apo-4'-carotenal oxygenase; Aldehyde dehydrogenase ylo-1; Beta-apo-4'-carotenal dehydrogenase; Yellow protein 1; EC 1.2.1.82 from Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) (see 3 papers)
Q1K615 beta-apo-4'-carotenal oxygenase (EC 1.2.1.82) from Neurospora crassa (see 3 papers)
34% identity, 80% coverage
- function: Beta-apo-4'-carotenal oxygenase involved in the last step of synthesis of neurosporaxanthin, a carboxylic apocarotenoid acting as an essential protective pigment and leading to orange pigmentation (PubMed:18627463, PubMed:18812228, PubMed:19007949). Converts the aldehyde beta-apo-4'-carotenal into neurosporaxanthin (PubMed:18627463, PubMed:18812228, PubMed:19007949). Neurosporaxanthin is synthesized from geranyl-geranyl pyrophosphate (GGPP) through several enzymatic activities. Phytoene synthase activity performed by the bifunctional enzyme al-2 first produces phytoene from geranyl-geranyl pyrophosphate (GGPP). The phytoene dehydrogenase al-1 then introduces 5 desaturations to lead to 3,4-didehydrolycopene via the intermediates phytofluene, zeta-carotene, neurosporene and lycopene. Al-2 cyclase activity then converts 3,4-didehydrolycopene into torulene. Al-2 can also convet lycopene into gamma-carotene which in turn is converted to beta- carotene by an additional al-2 cyclization reaction. Torulene is the substrate of the dioxidase cao-2 that breaks the molecule, removing five carbon atoms to yield beta-apo-4'-carotenal, whereas the aldehyde dehydrogenase ylo-1 mediates the last step by converting beta-apo-4'- carotenal into neurosporaxanthin (Probable).
catalytic activity: 4'-apo-beta-carotenal + NAD(+) + H2O = neurosporaxanthin + NADH + 2 H(+) (RHEA:31515)
H6S33_000904 uncharacterized protein from Morchella sextelata
38% identity, 85% coverage
- Comparative Transcriptome Profiles of the Response of Mycelia of the Genus Morchella to Temperature Stress: An Examination of Potential Resistance Mechanisms
Yue, Journal of fungi (Basel, Switzerland) 2024 - “...acid hydroxylase (H6S33_000109), mitochondrial dicarboxylate carrier protein (H6S33_000464), putative Fe-containing alcohol dehydrogenase (H6S33_000501), aldehyde dehydrogenase (H6S33_000904, H6S33_011849), oxidoreductase (H6S33_011977), and pyruvate decarboxylase (H6S33_012945). The functions of the genes in module II were related to the catabolic process of glucose with putative MFS monosaccharide transporter (H6S33_000450), alpha/beta-hydrolase...”
- “...acid hydroxylase (H6S33_000109), mitochondrial dicarboxylate carrier protein (H6S33_000464), putative Fe-containing alcohol dehydrogenase (H6S33_000501), aldehyde dehydrogenase (H6S33_000904, H6S33_011849), oxidoreductase (H6S33_011977), and pyruvate decarboxylase (H6S33_012945), were upregulated in Morchella mycelia ( Figure 5 A), indicating that high-temperature stress leads to excessive accumulation of ROS in mycelial cells. As...”
CtCNB1_1309 aldehyde dehydrogenase from Comamonas testosteroni CNB-2
CTCNB1_RS06680 coniferyl aldehyde dehydrogenase from Comamonas thiooxydans
34% identity, 89% coverage
- Delineation of Steroid-Degrading Microorganisms through Comparative Genomic Analysis
Bergstrand, mBio 2016 - “...conclusion which is further supported by our analysis. We further predict that genes CtCNB1_1308 , CtCNB1_1309 , CtCNB1_1310 , ORF6 , ORF7 , CtCNB1_1347 , and CtCNB1_1348 in strain CNB-2 are involved in cholate degradation but not in testosterone degradation, as they are conserved in Proteobacteria...”
- “...predicted to degrade both substrates but not in those predicted to degrade only testosterone. Accordingly, CtCNB1_1309 , CtCNB1_1347 , and CtCNB1_1348 are homologs of the cholate side chain degradation genes sad , sal , and shy , respectively, which were identified in Pseudomonas sp. strain Chol1...”
- Degradation of Bile Acids by Soil and Water Bacteria
Feller, Microorganisms 2021 - “...RHA1_RS28400 (CasD) absent Steroid aldolase C211_RS11205 (Sal1) CTCNB1_RS06875 absent absent Steroid aldehyde dehydrogenase C211_RS11010 (Sad) CTCNB1_RS06680 absent absent 2-hydroxy-CoA dehydrogenase absent absent RHA1_RS28410 absent Steroid thiolase absent absent RHA1_RS28390 (CasB) absent C3 side-chain degradation CoA-ligase C211_RS11185 (StdA2 *) CTCNB1_RS06820 RHA1_RS28425 (CasI) absent ACADs C211_RS11105 (Scd2A) CTCNB1_RS06815...”
HMPREF0010_01789 coniferyl aldehyde dehydrogenase from Acinetobacter baumannii ATCC 19606 = CIP 70.34 = JCM 6841
34% identity, 89% coverage
- Delineating the Plausible Molecular Vaccine Candidates and Drug Targets of Multidrug-Resistant Acinetobacter baumannii
Mujawar, Frontiers in cellular and infection microbiology 2019 - “...HMPREF0010_01461, and HMPREF0010_02576, were unique in having overlaps across CC, DC, and EC measures, while HMPREF0010_01789 from EC and three candidates from BC, namely, HMPREF0010_03553, HMPREF0010_01114, and HMPREF0010_00382, were unique. It is important to note that sorting of the whole genome proteins as per the four...”
- Polymyxin Resistance in Acinetobacter baumannii: Genetic Mutations and Transcriptomic Changes in Response to Clinically Relevant Dosage Regimens
Cheah, Scientific reports 2016 - “...Hypothetical protein 0.43 0.71 3.25E-05 ABBFA_000206 HMPREF0010_02442 51.7% Methyltransferase domain protein 0.83 1.45 6.02E-06 ABBFA_003085 HMPREF0010_01789 51.7% Coniferyl aldehyde dehydrogenase (CALDH) 1.23 1.60 3.22E-06 ABBFA_000998 HMPREF0010_02245 51.3% Phthalate dioxygenase reductase (PDR) 2.06 1.88 2.64E-06 Component 2 of the SPLS-DA model described gene expression profiles common to...”
- Colistin-resistant, lipopolysaccharide-deficient Acinetobacter baumannii responds to lipopolysaccharide loss through increased expression of genes involved in the synthesis and transport of lipoproteins, phospholipids, and poly-β-1,6-N-acetylglucosamine
Henry, Antimicrobial agents and chemotherapy 2012 - “...HMPREF0010_03598 HMPREF0010_00007 HMPREF0010_03239 HMPREF0010_01789 HMPREF0010_03533 HMPREF0010_03604 HMPREF0010_03298 HMPREF0010_01111 HMPREF0010_02865...”
Q6H627 aldehyde dehydrogenase [NAD(P)+] (EC 1.2.1.5) from Oryza sativa (see paper)
33% identity, 87% coverage
ABBFA_003085 Coniferyl aldehyde dehydrogenase(CALDH) from Acinetobacter baumannii AB307-0294
34% identity, 89% coverage
Q7XR89 aldehyde dehydrogenase [NAD(P)+] (EC 1.2.1.5) from Oryza sativa (see paper)
35% identity, 83% coverage
ACIAD0503 coniferyl aldehyde dehydrogenase (CALDH) from Acinetobacter sp. ADP1
33% identity, 89% coverage
Q0DZ46 aldehyde dehydrogenase [NAD(P)+] (EC 1.2.1.5) from Oryza sativa (see paper)
32% identity, 86% coverage
CC1849 coniferyl aldehyde dehydrogenase from Caulobacter crescentus CB15
34% identity, 88% coverage
PMM0331 Putative aldehyde dehydrogenase from Prochlorococcus marinus sp. MED4
33% identity, 89% coverage
- Bioinformatic evaluation of L-arginine catabolic pathways in 24 cyanobacteria and transcriptional analysis of genes encoding enzymes of L-arginine catabolism in the cyanobacterium Synechocystis sp. PCC 6803
Schriek, BMC genomics 2007 - “...n.d PMT0395 n.d PMT0191 Prochlorococcus marinus MED 4 PMM1084, PMM0045 PMM1686 n.d PMM0615 n.d PMM1215, PMM0331 Prochlorococcus marinus NATL 2A PMN2A_0665, PMN2A_1378 PMN2A_1287 n.d PMN2A_0052 n.d PMN2A_1709 Synechococcus sp. CC 9605 Syncc9605_1621, Syncc9605_2513 Syncc9605_1082Syncc9605_2591 n.d Syncc9605_1134 n.d Syncc9605_0497 Synechococcus sp. CC 9902 Syncc9902_1380, Syncc9902_2172 Syncc9902_2230 n.d...”
- “...Prochlorococcus marinus MIT 9313 PMT2214 PMT0331, PMT1493 PMT0191 Prochlorococcus marinus MED 4 PMM1686 PMM1301, PMM1472 PMM0331 Prochlorococcus marinus NATL 2A PMN2A_1287 PMN2A_0867, PMN2A_1003 PMN2A_1709 Synechococcus sp. CC 9605 Syncc9605_1082, Syncc9605_2591 Syncc9605_0858, Syncc9605_2052, Syncc9605_0659 Syncc9605_0497 Synechococcus sp. CC 9902 Syncc9902_2230 Syncc9902_1534, Syncc9902_0620 Syncc9902_1838 Synechococcus sp. WH 8102...”
A1S_0449 coniferyl aldehyde dehydrogenase (CALDH) from Acinetobacter baumannii ATCC 17978
36% identity, 85% coverage
LOC112010330 aldehyde dehydrogenase family 3 member F1 from Quercus suber
34% identity, 87% coverage
- Transcriptomic and physiological responses of Quercus acutissima and Quercus palustris to drought stress and rewatering
Kim, Frontiers in plant science 2024 - “...palustris showed differential expression of genes encoding aldehyde dehydrogenase family 3 member F1-like (LOC112001970, LOC112010329, LOC112010330, LOC112010332, and LOC112010331), fructose-1,6-bisphosphatase, cytosolic protein (LOC112005255), alcohol dehydrogenase-like 2 isoform X1 (LOC112023924), alcohol dehydrogenase-like 2 (LOC112023922), which were significantly downregulated in both C vs. D comparisons. Downregulated genes were...”
- “...yet completely escaped the stressed state. The aldehyde dehydrogenase family (LOC112010331, LOC112010332, LOC112001970, LOC112010329, and LOC112010330) of enzymes, along with the cofactor, NAD+ or NADP+, convert aldehydes into carboxylic acids, NADH, or NADPH ( Brocker etal., 2013 ). Compounds containing aldehyde functional groups are important intermediates...”
A9762_21150 coniferyl aldehyde dehydrogenase from Pandoraea sp. ISTKB
36% identity, 87% coverage
LOC112010332 LOW QUALITY PROTEIN: aldehyde dehydrogenase family 3 member F1 from Quercus suber
31% identity, 82% coverage
- Transcriptomic and physiological responses of Quercus acutissima and Quercus palustris to drought stress and rewatering
Kim, Frontiers in plant science 2024 - “...showed differential expression of genes encoding aldehyde dehydrogenase family 3 member F1-like (LOC112001970, LOC112010329, LOC112010330, LOC112010332, and LOC112010331), fructose-1,6-bisphosphatase, cytosolic protein (LOC112005255), alcohol dehydrogenase-like 2 isoform X1 (LOC112023924), alcohol dehydrogenase-like 2 (LOC112023922), which were significantly downregulated in both C vs. D comparisons. Downregulated genes were significantly...”
- “...the plant had not yet completely escaped the stressed state. The aldehyde dehydrogenase family (LOC112010331, LOC112010332, LOC112001970, LOC112010329, and LOC112010330) of enzymes, along with the cofactor, NAD+ or NADP+, convert aldehydes into carboxylic acids, NADH, or NADPH ( Brocker etal., 2013 ). Compounds containing aldehyde functional...”
PSHAa2139 putative aldehyde dehydrogenase from Pseudoalteromonas haloplanktis TAC125
32% identity, 91% coverage
RPA1687 putative aldehyde dehydrogenase from Rhodopseudomonas palustris CGA009
35% identity, 84% coverage
- Multidimensional optimization for accelerating light-powered biocatalysis in Rhodopseudomonas palustris
Zhang, Biotechnology for biofuels and bioproducts 2023 - “...represent the base strain, the mutant with RPA1206 deletion, and the mutant with RPA1206 , RPA1687 and RPA1725 deletions, respectively, containing CouBA-ADH2. c The effect of light exposure on the VA productions from different concentrations of FA incubating with the resting cells of RVA3 under dark-...”
- “...suggesting that there are other ALDHs involved in VAC formation. Next, we proceeded to delete RPA1687 (coniferyl aldehyde reductase) and RPA1725 (aldehyde reductase to phenolic acid) to further disrupt VAC formation from vanillin (Fig. S2a). Encouragingly, 5mM VA with~100% conversion was obtained in R. palustris RVA3...”
CALB_PSEUH / O86447 Coniferyl aldehyde dehydrogenase; CALDH; EC 1.2.1.68 from Pseudomonas sp. (strain HR199 / DSM 7063) (see 2 papers)
calB coniferyl-aldehyde dehydrogenase; EC 1.2.1.68 from Pseudomonas sp. HR199 (see paper)
32% identity, 89% coverage
- function: Catalyzes the NAD(+)-dependent oxidation of coniferyl aldehyde to ferulic acid and which is induced during growth with eugenol as the carbon source.
catalytic activity: (E)-coniferaldehyde + NADP(+) + H2O = (E)-ferulate + NADPH + 2 H(+) (RHEA:23964)
catalytic activity: (E)-coniferaldehyde + NAD(+) + H2O = (E)-ferulate + NADH + 2 H(+) (RHEA:23968)
subunit: Homodimer.
HFD1 / Q04458 fatty aldehyde dehydrogenase HFD1 (EC 1.2.1.3; EC 1.2.1.64) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 2 papers)
HFD1_YEAST / Q04458 Fatty aldehyde dehydrogenase HFD1; Hexadecenal dehydrogenase; EC 1.2.1.3; EC 1.2.1.64 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 9 papers)
YMR110C Hfd1p from Saccharomyces cerevisiae
32% identity, 81% coverage
- function: Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid (PubMed:22633490). Involved in coenzyme Q (CoQ) biosynthesis, catalyzing the last step in the tyrosine to 4-hydroxybenzoate (4-HB) pathway. Oxidizes 4-hydroxybenzaldehyde (4-Hbz) to 4-HB, the aromatic precursor for coenzyme Q (PubMed:27669165, PubMed:27693056).
catalytic activity: an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+) (RHEA:16185)
catalytic activity: hexadecanoate + NADH + 2 H(+) = hexadecanal + NAD(+) + H2O (RHEA:33739)
catalytic activity: 4-hydroxybenzaldehyde + NAD(+) + H2O = 4-hydroxybenzoate + NADH + 2 H(+) (RHEA:20305)
disruption phenotype: Results in coenzyme Q deficiency. - Fatty aldehyde dehydrogenase multigene family involved in the assimilation of n-alkanes in Yarrowia lipolytica
Iwama, The Journal of biological chemistry 2014 - “...Ald4p (P46367), Ald5p (P40047), and Hfd1p (Q04458) of S. cerevisiae, and YALI0E00264p (Q6C7J6), YALI0C03025p (Q6CD79), YALI0F04444p (Q6C2W9), YALI0D07942p...”
- Saccharomyces cerevisiae responds similarly to co-culture or to a fraction enriched in Metschnikowia pulcherrima extracellular vesicles
Mejias-Ortiz, Microbial biotechnology 2023 - “...only two of them, that are not an integral part of the pathway (YLR446W and YMR110C), appear downregulated. Although this pathway is labelled as Glycolysis/Gluconeogenesis the results indicate that mostly the glycolytic pathway is upregulated. Certainly, MDH2 (YOL126C) coding for the enzyme catalysing the first irreversible...”
- Heme, A Metabolic Sensor, Directly Regulates the Activity of the KDM4 Histone Demethylase Family and Their Interactions with Partner Proteins
Konduri, Cells 2020 - “...BAR domain protein TAF7, TAF7L, FECH + + HEM15 YOR176W 398365579 Ferrochelatase FECH + HFD1 YMR110C 6323757 Fatty aldehyde dehydrogenase ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2 + HSP42 YDR171W 6320376 Small heat-shock protein (sHSP) with chaperone activity INA22 YIR024C 6322215 Inner membrane assembly complex subunit 22 IPP1 YBR011C...”
- Lipid droplet dynamics in budding yeast
Wang, Cellular and molecular life sciences : CMLS 2015 - “...that localizes to early and late Golgi vesicles HFD1 YMR110C V V V LP/E/M Hexadecenal dehydrogenase HHF1/2 V N Histone H4 HOM3 YBR009C/ YNL030W YER052C V C...”
- High confidence proteomic analysis of yeast LDs identifies additional droplet proteins and reveals connections to dolichol synthesis and sterol acetylation
Currie, Journal of lipid research 2014 - “...A, B, G ( 69 ) YIR038C GTT1 Glutathione transferase B, G ( 22 ) YMR110C HFD1 Fatty aldehyde dehydrogenase B, G Current work YBR204C LDH1 Serine hydrolase, weak TG lipase activity G ( 70 ) ( 70 ) YML059C NTE1 Phospholipase B YDL193W NUS1 Putative...”
- Conservation of nucleosome positions in duplicated and orthologous gene pairs
Nishida, TheScientificWorldJournal 2012 - “...0.98321165 0.95995151 401540 + chr13 YMR078C 0.969392941 0.976546196 424727 chr13 YMR081C 0.981254312 0.956294421 431094 chr13 YMR110C 0.961424621 0.983151943 491991 chr13 YMR116C 0.977129849 0.989254306 500687 chr13 YMR137C 0.971971845 0.978526214 544962 chr13 YMR138W 0.978634859 0.963362392 545154 + chr13 YMR152W 0.958913422 0.961601086 563095 + chr13 YMR197C 0.960464224 0.981756931 659197...”
- “...YDR019C AFUA_1G10780 0.673590566 YDR262W AFUA_8G05360 0.668577442 YJR160C AFUA_3G01700 0.655149877 YBL087C AFUA_2G03380 0.654275917 YDR120C AFUA_3G04200 0.653965099 YMR110C AFUA_4G13500 0.649573592 YDR479C AFUA_2G01510 0.649340576 YLR307W AFUA_4G09940 0.641152119 YLL050C AFUA_5G10570 0.636927762 YMR011W AFUA_2G11520 0.631877767 YGR149W AFUA_3G08240 0.627253467 YKL125W AFUA_1G02590 0.626251676 YDL247W AFUA_3G01700 0.621782331 YHR165C AFUA_2G03030 0.616638486 YLR355C AFUA_3G14490 0.615946987 YLR307W...”
- YPR139c/LOA1 encodes a novel lysophosphatidic acid acyltransferase associated with lipid droplets and involved in TAG homeostasis
Ayciriex, Molecular biology of the cell 2012 - “...1.67 TGL1 YKL140w Sterol esterase TAG metabolism + 1.64 TDH3 YGR192c GAPDH Glycolysis 1.63 HFD1 YMR110c Putative fatty aldehyde dehydrogenase Cellular process + 1.33 TDH1 YJL052w GAPDH Glycolysis + 1.06 EHT1 YBR177c Medium-chain fatty acid ethyl ester synthase FA metabolism + 0.98 TGL4 YKR089c Lipase TAG...”
- Lipid particles/droplets of the yeast Saccharomyces cerevisiae revisited: lipidome meets proteome
Grillitsch, Biochimica et biophysica acta 2011 - “...GTT1 YIR038C 2 8 ER/M/PM Glutathione S-transferase GVP36 YIL041W 3 C/G BAR domain-containing protein HFD1 YMR110C 7 18 M/LP/End Putative fatty aldehyde dehydrogenase HSP12 YFL014W 6 C/PM/N Heat shock protein KAR2 YJL034W 9 ER ATPase LAP4 YKL103C 3 V Vacuolar aminopeptidase LDB16 YCL005W LP/M Unknown MSC1...”
- Construction and application of a protein and genetic interaction network (yeast interactome)
Stuart, Nucleic acids research 2009 - “...coenzyme A and oxaloacetate to citrate); rate-limiting TCA cycle enzyme YNR034W-A YNR034W-A 5.91 Hypothetical protein YMR110C HFD1 5.78 Putative fatty aldehyde dehydrogenase, located in the mitochondrial outer membrane and also in lipid particles YPR002W PDH1 5.55 Mitochondrial protein that participates in respiration, induced by diauxic shift...”
- More
CCM_02203 aldehyde dehydrogenase, putative from Cordyceps militaris CM01
34% identity, 71% coverage
- Metabolic comparison of aerial and submerged mycelia formed in the liquid surface culture of Cordyceps militaris
Suparmin, MicrobiologyOpen 2019 - “...result was shown by oxidoreductase (CCM_01934), followed by alcohol dehydrogenase (ADH; CCM_09633), aldehyde dehydrogenase (ALDH; CCM_02203), hexokinase (HK; CCM_06280), alcohol dehydrogenase (ADH; CCM_02484), succinate dehydrogenase (SDH; CCM_07146), glucose6phosphate1dehydrogenase (G6PDH; CCM_06983), 5nucleotidase (5NT; CCM_00622), and adenylate cyclase, putative (ADCY; CCM_02396) in the submerged mycelia. In contrast, in...”
- “...(CCM_01934) was the most strongly expressed, followed by alcohol dehydrogenase (ADH, CCM_09633), aldehyde dehydrogenase (ALDH; CCM_02203), hexokinase (HK; CCM_06280), alcohol dehydrogenase (ADH; CCM_02484), succinate dehydrogenase (SDH; CCM_07146), glucose6phosphate1dehydrogenase (G6PDH; CCM_06983), 5nucleotidase (5NT; CCM_00622), and adenylate cyclase, putative (ADCY; CCM_02396) at 12th day and maintained in the...”
WP_154716401 coniferyl aldehyde dehydrogenase from Sterolibacterium denitrificans
32% identity, 88% coverage
- ATP-dependent hydroxylation of an unactivated primary carbon with water
Jacoby, Nature communications 2020 - “...aldehyde to the C26 alcohol. Recently, a cholesterol induced gene was identified in S. denitrificans (WP_154716401) that was hypothesised to encode an aldehyde dehydrogenase (C26-ALDH) involved in cholesterol C26 oxidation 25 . We heterologously expressed this gene in E. coli , and extracts from cells producing...”
- “...control experiments no such conversions were observed in E. coli wild-type without the plasmid expressing WP_154716401. In the presence of MgATP and CoA, the DDO-26-carboxylate formed was further converted to DDO-26-CoA by the previously characterised AMP-forming C26-carboxylate CoA ligase activity 25 , thereby initiating -oxidation of...”
Q68D64 Aldehyde dehydrogenase family 3 member A2 (Fragment) from Homo sapiens
42% identity, 60% coverage
MSMEG_2242 coniferyl aldehyde dehydrogenase from Mycobacterium smegmatis str. MC2 155
33% identity, 85% coverage
- Genome-Wide Transcriptional Response of Mycobacterium smegmatis MC2155 to G-Quadruplex Ligands BRACO-19 and TMPyP4
Shitikov, Frontiers in microbiology 2022 - “...DEGs that are co-regulated by both compounds and harbor/neighbor PQSs include MSMEG_4727, MSMEG_1680, MSMEG_4689, MSMEG_3948, MSMEG_2242, MSMEG_3121, and MSMEG_2148 (contain PQSs on the template strand of the gene); MSMEG_1488, MSMEG_0868, MSMEG_6223, MSMEG_5397, and MSMEG_4202 (contain PQSs on the mRNA-like strand); MSMEG_6567 (contains one PQS on each...”
WP_099520946 aldehyde dehydrogenase family protein from Paenibacillus sp. BIHB 4019
32% identity, 89% coverage
BL1124 fatty aldehyde dehydrogenase from Bifidobacterium longum NCC2705
38% identity, 53% coverage
BBMN68_872 aldehyde dehydrogenase family protein from Bifidobacterium longum subsp. longum BBMN68
38% identity, 53% coverage
BLJ_0565 aldehyde dehydrogenase family protein from Bifidobacterium longum subsp. longum JDM301
37% identity, 53% coverage
Ga0061065_12214 coniferyl aldehyde dehydrogenase from Marinomonas fungiae
32% identity, 85% coverage
MSMEG_0889, MSMEI_0868 aldehyde dehydrogenase family protein from Mycolicibacterium smegmatis MC2 155
A0QQV4 Aldehyde dehydrogenase from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)
MSMEG_0889 succinic semialdehyde dehydrogenase from Mycobacterium smegmatis str. MC2 155
33% identity, 80% coverage
- Interactome Analysis Identifies MSMEI_3879 as a Substrate of Mycolicibacterium smegmatis ClpC1
Ogbonna, Microbiology spectrum 2023 - “...0.01 0.01 A0QSB2 MSMEG_1417, MSMEI_1382 Glyoxalase family protein 0.11 0.12 0.09 0.01 A0QQV4 gabD2 , MSMEG_0889, MSMEI_0868 Aldehyde dehydrogenase 0.14 0 0.11 0.03 A0R2L3 MSMEG_5155, MSMEI_5022 Nitroreductase 0.07 0.04 0.28 0.07 A0QYH8 MSMEG_3663, MSMEI_3576 Oxidoreductase 0.06 0.01 A0QSB9 mftD , lldD1 , MSMEG_1424, MSMEI_1389 FMN-dependent dehydrogenase...”
- “...ATP synthase subunit alpha ClpC1/P2 KD a 0.124 14.667 WT, EQ, NTD A0QQV4 gabD2 , MSMEG_0889, MSMEI_0868 Aldehyde dehydrogenase ClpC1/P2 KD a 0.123 15.417 WT, EQ, NTD, CORE A0QQQ1 sodC , MSMEG_0835, MSMEI_0816 Superoxide dismutase ClpC1/P2 KD a 0.100 6.500 WT, NTD, CORE A0R0T8 dnaJ2 ,...”
- “...0.01 A0QSB2 MSMEG_1417, MSMEI_1382 Glyoxalase family protein 0.11 0.12 0.09 0.01 A0QQV4 gabD2 , MSMEG_0889, MSMEI_0868 Aldehyde dehydrogenase 0.14 0 0.11 0.03 A0R2L3 MSMEG_5155, MSMEI_5022 Nitroreductase 0.07 0.04 0.28 0.07 A0QYH8 MSMEG_3663, MSMEI_3576 Oxidoreductase 0.06 0.01 A0QSB9 mftD , lldD1 , MSMEG_1424, MSMEI_1389 FMN-dependent dehydrogenase 0.02...”
- “...synthase subunit alpha ClpC1/P2 KD a 0.124 14.667 WT, EQ, NTD A0QQV4 gabD2 , MSMEG_0889, MSMEI_0868 Aldehyde dehydrogenase ClpC1/P2 KD a 0.123 15.417 WT, EQ, NTD, CORE A0QQQ1 sodC , MSMEG_0835, MSMEI_0816 Superoxide dismutase ClpC1/P2 KD a 0.100 6.500 WT, NTD, CORE A0R0T8 dnaJ2 , MSMEG_4504,...”
- The Benefits of Toxicity: M. smegmatis VapBC TA Module Is Induced by Tetracycline Exposure and Promotes Survival
Zamakhaev, Microorganisms 2023 - “...phenomenon was observed for gamma-aminobutyric acid shunt, i.e., succinate-semialdehyde dehydrogenase MSMEG_6452 was substituted by isoenzyme MSMEG_0889. The data on the abundance of proteins involved in amino acid metabolism under VapC overexpression demonstrated the decrease amidst synthase enzymes, such as tryptophan synthase MSMEG_3220, asparagine synthase MSMEG_2594, methionine...”
- “...step in the 4-aminobutyric acid pathway (we also detected the increased abundance of succinate-semialdehyde dehydrogenase MSMEG_0889 that is the component of this pathway) [ 56 ]. Additionally, the upregulation of glutamate decarboxylase MSMEG_1574 suggests a potential role in acid stress resistance [ 57 ]. Overall, our...”
- Interactome Analysis Identifies MSMEI_3879 as a Substrate of Mycolicibacterium smegmatis ClpC1
Ogbonna, Microbiology spectrum 2023 - “...diphosphate synthase (flavodoxin) 0.01 0.01 A0QSB2 MSMEG_1417, MSMEI_1382 Glyoxalase family protein 0.11 0.12 0.09 0.01 A0QQV4 gabD2 , MSMEG_0889, MSMEI_0868 Aldehyde dehydrogenase 0.14 0 0.11 0.03 A0R2L3 MSMEG_5155, MSMEI_5022 Nitroreductase 0.07 0.04 0.28 0.07 A0QYH8 MSMEG_3663, MSMEI_3576 Oxidoreductase 0.06 0.01 A0QSB9 mftD , lldD1 , MSMEG_1424,...”
- “..., MSMEG_4938, MSMEI_4811 ATP synthase subunit alpha ClpC1/P2 KD a 0.124 14.667 WT, EQ, NTD A0QQV4 gabD2 , MSMEG_0889, MSMEI_0868 Aldehyde dehydrogenase ClpC1/P2 KD a 0.123 15.417 WT, EQ, NTD, CORE A0QQQ1 sodC , MSMEG_0835, MSMEI_0816 Superoxide dismutase ClpC1/P2 KD a 0.100 6.500 WT, NTD, CORE...”
- Synthesis and Characterization of Novel 2-Acyl-3-trifluoromethylquinoxaline 1,4-Dioxides as Potential Antimicrobial Agents
Buravchenko, Pharmaceuticals (Basel, Switzerland) 2022 - “...smegmatis tfqR2 , in MSMEG_4863 (LLM class flavin-dependent oxidoreductase) in M. smegmatis tfqR4 , in MSMEG_0889 (succinate-semialdehyde dehydrogenase) in M. smegmatis tfqR6 , and in MSMEG_6440 (monooxygenase, flavin-binding family protein) in M. smegmatis tfqR7 . M. smegmatis tfqR1 harbored an SNP in MSMEG_1914, encoding the alternative...”
- “...as its mutation led to a higher level of resistance, as compared to those in MSMEG_0889 and MSMEG_6440. 3. Materials and Methods 3.1. Synthesis 3.1.1. Materials and General Methods NMR spectra of all synthesized compounds were recorded on a VXR-400 instrument (Varian, 3100 Hansen Way, Palo...”
- Biochemical and phenotypic characterisation of the Mycobacterium smegmatis transporter UspABC
Karlikowska, Cell surface (Amsterdam, Netherlands) 2021 - “...metabolism 1.8 MSMEG_2433 Rv2911 ( dacB2 ) D-alanyl-D-alanine carboxypeptidase Cell wall and cell processes 1.8 MSMEG_0889 succinic semialdehyde dehydrogenase Intermediary metabolism and respiration 1.7 MSMEG_5685 Rv0883c DNA-binding protein Information pathways 1.7 MSMEG_4976 isochorismatase hydrolase Intermediary metabolism and respiration 1.6 MSMEG_1410 Rv0687 carveol dehydrogenase Intermediary metabolism and...”
LOC107802760 aldehyde dehydrogenase family 3 member H1-like from Nicotiana tabacum
38% identity, 61% coverage
Afu8g02310 aldehyde dehydrogenase ALDH from Aspergillus fumigatus Af293
31% identity, 70% coverage
- Evolutionary Analysis of Sequence Divergence and Diversity of Duplicate Genes in Aspergillus fumigatus
Yang, Evolutionary bioinformatics online 2012 - “...0.62 [0.97, 1.91] Afu5g05640 4.22 [1.95, 1.07] Afu1g03150 0.56 [0.96, 1.83] Afu1g05720 1.93 [1.78, 0.69] Afu8g02310 0.54 [0.96, 1.85] Afu4g01550 2.63 [1.22, 0.78] Afu3g01610 0.52 [1.29, 2.15] Afu4g09300 1.02 [1.83, 1.46] Afu1g15120 0.50 [0.67, 1.48] Afu6g12910 1.98 [1.81, 0.62] Afu3g00450 0.49 [0.80, 1.61] Afu1g12460 2.33 [2.14,...”
LOC112010331 aldehyde dehydrogenase family 3 member F1 from Quercus suber
37% identity, 61% coverage
- Transcriptomic and physiological responses of Quercus acutissima and Quercus palustris to drought stress and rewatering
Kim, Frontiers in plant science 2024 - “...expression of genes encoding aldehyde dehydrogenase family 3 member F1-like (LOC112001970, LOC112010329, LOC112010330, LOC112010332, and LOC112010331), fructose-1,6-bisphosphatase, cytosolic protein (LOC112005255), alcohol dehydrogenase-like 2 isoform X1 (LOC112023924), alcohol dehydrogenase-like 2 (LOC112023922), which were significantly downregulated in both C vs. D comparisons. Downregulated genes were significantly upregulated in...”
- “...that the plant had not yet completely escaped the stressed state. The aldehyde dehydrogenase family (LOC112010331, LOC112010332, LOC112001970, LOC112010329, and LOC112010330) of enzymes, along with the cofactor, NAD+ or NADP+, convert aldehydes into carboxylic acids, NADH, or NADPH ( Brocker etal., 2013 ). Compounds containing aldehyde...”
WP_076384861 aldehyde dehydrogenase family protein from Pseudomonas sp. A214
32% identity, 85% coverage
XP_813115 aldehyde dehydrogenase, putative from Trypanosoma cruzi
30% identity, 75% coverage
- Subcellular proteomics of Trypanosoma cruzi reservosomes
Sant'Anna, Proteomics 2009 - “...matrix N 119 Succinyl-coa ligase [GDP-forming] beta-chain XP_818583 Tricarboxylic acid cycle N 120 Aldehyde dehydrogenase XP_813115 Oxidation of aldehydes N 121 ADP, ATP carrier protein 1 XP_819458 Mitochodria inner membrane, transport Y (3) (13) others 122 Glucose-regulated protein 78 XP_809817 Endoplasmic reticulum, protein folding N 123...”
AL221_ARATH / Q0WSF1 Aldehyde dehydrogenase 22A1; Novel aldehyde dehydrogenase family 22 member A1; EC 1.2.1.3 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
aldh22A1 / CAE48165.1 putative aldehyde dehydrogenase from Arabidopsis thaliana (see paper)
AT3G66658 ALDH22a1 (Aldehyde Dehydrogenase 22a1); 3-chloroallyl aldehyde dehydrogenase/ oxidoreductase from Arabidopsis thaliana
30% identity, 70% coverage
- catalytic activity: an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+) (RHEA:16185)
- Trans-cinnamaldehyde-related overproduction of benzoic acid and oxidative stress on Arabidopsis thaliana
López-González, Frontiers in plant science 2023 - “...AT4G34240 TCACTGGTGGAGCAAGAGTT/GATCCTCCTAGCAGCCACTT 140 1.995 ALDH7B4 AT1G54100 TCAGAACGCCCTAACCACAT/CACCACACATGGCCGTAAAA 250 2.001 ALDH11A3 AT2G24270 CCGATAGCTTCCCCGGTAAT/GGAGGTTTGAGGACAAGGGA 163 1.995 ALDH22A1 AT3G66658 CTTTCTGAGGGCGAACGATG/CACCAAGGGGATGGAACTCT 97 2.000 Gene expression analyses were performed following the Minimum Information for publication of Quantitative real-time PCR Experiments (MIQE) guidelines ( Bustin etal., 2009 ). The qPCR reactions were...”
- Development and Validation of Markers for the Fertility Restorer Gene Rf1 in Sunflower
Horn, International journal of molecular sciences 2019 - “...presence of the T-cytoplasm proved to be ALDH2B2 [ 29 , 30 ]. ALDH 22A1 (AT3G66658) has been well-characterized in Arabidopsis thaliana , where it showed a cytoplasmic localization and is apart from other tissues, also expressed in anthers [ 57 ]. The poly(A) polymerase 3...”
- The modulation of acetic acid pathway genes in Arabidopsis improves survival under drought stress
Rasheed, Scientific reports 2018 - “...0.78 0.81 0.74 AT5G62530 ALDH12A1 Mitochondria 1 0.95 0.75 1.07 1.83 0.89 1.13 0.94 1.63 AT3G66658 ALDH22A1 Cytoplasm 1 1.00 1.03 0.84 0.76 1.00 0.91 0.71 0.41 PDC Gene Family (4 members in Arabidopsis ) AT4G33070 PDC1 Cytoplasm 3 1.74 4.38 7.92 10.71 1.19 1.16 2.52...”
- Comparative study of the aldehyde dehydrogenase (ALDH) gene superfamily in the glycophyte Arabidopsis thaliana and Eutrema halophytes
Hou, Annals of botany 2015 - “...AT3G48170 AT2G24270 AT5G62530 AT2G39800 AT3G55610 AT3G66658 AtALDH10A9 AtALDH11A3 AtALDH12A1 AtALDH18B1 AtALDH18B2 AtALDH22A1 NP_190400.1 NP_001189589.1...”
- Analysis of miRNAs and their targets during adventitious shoot organogenesis of Acacia crassicarpa
Liu, PloS one 2014 - “...cycloidea andPCF transcription factor 3 AT3G33076 3 transposable element gene AT3G33084 3 transposable element gene AT3G66658 3 aldehyde dehydrogenase 22A1 AT4G22415 3 transposable element gene MIR390 AT2G38325 3 MIR390A; miRNA MIR393 AT3G62980 1 F-box/RNI-like superfamily protein AT4G03190 2 GRR1-like protein 1 MIR394 AT1G27340 1 Galactose oxidase/kelch...”
- Aldehyde dehydrogenase (ALDH) superfamily in plants: gene nomenclature and comparative genomics
Brocker, Planta 2013 - “...ALDH18B2 824727 P5CS2 NP_191120.2 AT3G55610 3 20 726 Family 22 ALDH22A1 819849 T8E24.4; T8E24_4 NP_974242.1 AT3G66658 3 14 596 Kirch et al. 2004 Exon and amino acid figures obtained from NCBI entries Table 4 Chlamydomonas reinhardtii ALDH superfamily: unified nomenclature and gene information Family Gene name...”
- Aldehyde Dehydrogenases in Arabidopsis thaliana: Biochemical Requirements, Metabolic Pathways, and Functional Analysis
Stiti, Frontiers in plant science 2011 - “...Deuschle et al. ( 2001 , 2004 ); Miller et al. ( 2009 ) ALDH22A1 At3g66658 Cytosol Plant specific ALDH Kirch et al. ( 2005 ), this review Data in bold refer to ALDHs that have been analyzed in our own laboratory . Molecular, Biochemical, and...”
- Versatile gene-specific sequence tags for Arabidopsis functional genomics: transcript profiling and reverse genetics applications
Hilson, Genome research 2004 - “...AT4G33950; AT5G01810; AT5G20250; AT5G25110 AT1G17290; AT3G30775; AT3G66658; AT4G33070; AT5G10860; AT5G17380 Cluster D. Down and late genes BP disaccharide...”
ald / Q4VKV0 4,4'-diapolycopenedial dehydrogenase (EC 1.2.99.10) from Methylomonas sp. (see 4 papers)
ALD_METSP / Q4VKV0 4,4'-diapolycopene aldehyde oxidase; 4,4'-diapolycopenedial dehydrogenase; 4,4'-diapolycopenoate synthase; EC 1.2.99.10 from Methylomonas sp. (see paper)
Q4VKV0 4,4'-diapolycopenoate synthase (EC 1.2.99.10) from Methylomonas sp. (see paper)
30% identity, 75% coverage
- function: Involved in the biosynthesis of C30 carotenoids. Catalyzes the oxidation of 4,4'-diapolycopene-4,4'-dial to yield 4,4'- diapolycopene-4,4'-dioic acid. Also able to catalyze the oxidation of 4,4'-diapolycopen-4-al to yield 4,4'-diapolycopen-4-oic acid.
catalytic activity: all-trans-4,4'-diapolycopen-4-al + A + H2O = all-trans-4,4'- diapolycopen-4-oate + AH2 + H(+) (RHEA:44716)
catalytic activity: all-trans-4,4'-diapolycopene-4,4'-dial + 2 A + 2 H2O = all- trans-4,4'-diapolycopene-4,4'-dioate + 2 AH2 + 2 H(+) (RHEA:42380)
disruption phenotype: Cells lacking this gene produce 4,4'- diapolycopene dialdehyde in addition to the 4,4'-diapophytoene precursor.
BADH1_ORYSJ / O24174 Betaine aldehyde dehydrogenase 1; OsBADH1; EC 1.2.1.8 from Oryza sativa subsp. japonica (Rice) (see 3 papers)
O24174 betaine-aldehyde dehydrogenase (EC 1.2.1.8) from Oryza sativa Japonica Group (see paper)
33% identity, 78% coverage
- function: Dehydrogenase that can use N-acetyl-gamma-aminobutyraldehyde (NAGABald), gamma-guanidinobutyraldehyde (GGBald), betaine aldehyde (Bet-ald), gamma-aminobutyraldehyde (GAB-ald), acetaldehyde, 4- aminobutylaldehyde (AB-ald), 3-aminopropionaldehyde (AP-ald), 4-N- trimethylaminobutyraldehyde (TMAB-ald) and 3-N- trimethylaminopropionaldehyde (TMAP-ald) as substrates. Catalyzes the oxidation of GAB-ald more efficiently than Bet-ald. May convert acetaldehyde into acetate, thus facilitating the production of acetyl- CoA in peroxisomes under anaerobic conditions.
catalytic activity: betaine aldehyde + NAD(+) + H2O = glycine betaine + NADH + 2 H(+) (RHEA:15305)
subunit: Homodimer. - Unique and Shared Proteome Responses of Rice Plants (Oryza sativa) to Individual Abiotic Stresses
Habibpourmehraban, International journal of molecular sciences 2022 - “...Figure 6 , agreed with the label-free shotgun proteomics results. These included Betaine aldehyde dehydrogenase (O24174), Fasciclin-like arabinogalactan protein 15 (Q7XIM4), t-SNARE coiled-coil homology domain-containing (Q8H5R6), and Anamorsin homolog 1 (Q7XQ97). Betaine aldehyde dehydrogenase protein was significantly reduced in abundance under drought and temperature stresses, and...”
- Pluronic F-68 Improves Callus Proliferation of Recalcitrant Rice Cultivar via Enhanced Carbon and Nitrogen Metabolism and Nutrients Uptake.
Kok, Frontiers in plant science 2021 - “...7 L-ascorbate peroxidase 1, cytosolic Q10N21 Amino Acid Biosynthesis 0.98254 8 Betaine aldehyde dehydrogenase 1 O24174 Amino Acid Biosynthesis 0.95400 9 Chitinase 2 Q7DNA1 Plant Defense 0.94951 10 60S ribosomal protein L37a-2 P0DKK2 Protein Biosynthesis 0.92619 11 Histone H3.3 Q0JCT1 Signaling and Cellular Process 0.85296 12...”
- RNASeq analysis of giant cane reveals the leaf transcriptome dynamics under long-term salt stress
Sicilia, BMC plant biology 2019 - “...5e-138 +17.324 14027.116788 Oryza sativa subsp . japonica Betaine aldehyde dehydrogenase 1 (BADH) (Swissprot ID: O24174) 85.80% 2e-94 +16.655 14027.196396 Oryza sativa Japonica Group Arginine decarboxylase 1 (ADC) (Nr ID: XP_015643038.1) 92.73% 1e-142 +18.455 Photosynthesis and photorespiration 14027.157747 Oryza sativa subsp. j aponica Group Ribulose bisphosphate...”
- Structural insights into betaine aldehyde dehydrogenase (BADH2) from Oryza sativa explored by modeling and simulations
Baicharoen, Scientific reports 2018 - “...rice quality and market price. Methods The sequence of BADH2 was obtained from Uniprot (Entry: O24174). A BLAST search based on the protein data bank revealed that the structures most similar to BADH2 was the 3-dimensional structure of aminoaldehyde dehydrogenase (AMADH) from Pisum sativum (PDB codes:...”
- Plant ALDH10 family: identifying critical residues for substrate specificity and trapping a thiohemiacetal intermediate
Kopečny, The Journal of biological chemistry 2013 - “...site-directed mutagenesis (17). Rice (OsAMADHs, UniProtKB numbers O24174 and Q84LK3) and barley enzymes (HvAMADHs, UniProtKB numbers Q94IC0 and Q94IC1) analyzed...”
- Distinct colonization patterns and cDNA-AFLP transcriptome profiles in compatible and incompatible interactions between melon and different races of Fusarium oxysporum f. sp. melonis.
Sestili, BMC genomics 2011 - “...0 0 0 0 0 0 2 0 0 0 2 P1409 TG-CA 305 -- O24174 Betaine aldehyde dehydrogenase (BADH). 2E-18 Response to stimulus 0 0 0 0 0 0 0 1 0 0 0 1 P1430 TA-CC 422 -- Q9S795 Betaine aldehyde dehydrogenase 1, chloroplast...”
R0KX92 Aldehyde dehydrogenase, mitochondrial (Fragment) from Anas platyrhynchos
30% identity, 88% coverage
Q38AY7 Aldehyde dehydrogenase, putative from Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
31% identity, 74% coverage
WP_019069277 aldehyde dehydrogenase from Streptomyces hokutonensis
35% identity, 66% coverage
WP_059082879 aldehyde dehydrogenase from Streptomyces scabiei
35% identity, 66% coverage
WP_055635242 aldehyde dehydrogenase from Streptomyces griseoruber
35% identity, 66% coverage
U3IM27 Aldehyde dehydrogenase, mitochondrial from Anas platyrhynchos platyrhynchos
30% identity, 94% coverage
- Effect of riboflavin deficiency on intestinal morphology, jejunum mucosa proteomics, and cecal microbiota of Pekin ducks
Xu, Animal nutrition (Zhongguo xu mu shou yi xue hui) 2023 - “...name Fold change P -value Glycolysis and gluconeogenesis U3I693 Acetyl-coenzyme A synthetase ACSS1 1.64 6.40E-04 U3IM27 Aldedh domain-containing protein ALDH1A2 2.17 2.55E-03 U3IKG5 Aldehyde dehydrogenase 9 family member A1 ALDH9A1 2.64 5.85E-05 B4Z854 Fructose-bisphosphate aldolase ALDOB 2.05 6.21E-04 U3IR48 Dihydrolipoyl dehydrogenase DLD 3.48 1.40E-05 U3J2H8 Fructose-bisphosphatase...”
- “...dehydrogenase family member 9 ACAD9 2.42 1.00E-04 R0LSV8 Electron transfer flavoprotein-ubiquinone oxidoreductase ETFDH 2.31 3.88E-05 U3IM27 Aldedh domain-containing protein ALDH2 2.17 2.55E-03 U3IKG5 Aldehyde dehydrogenase 9 family member A1 ALDH9A1 2.64 5.85E-05 U3I6S1 Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta HADHB 1.86 1.08E-06 R0LHP1 Hydroxyacyl-coenzyme A...”
- Integrated liver proteomics and metabolomics identify metabolic pathways affected by pantothenic acid deficiency in Pekin ducks
Tang, Animal nutrition (Zhongguo xu mu shou yi xue hui) 2022 - “...acetyltransferase component of pyruvate dehydrogenase complex PDHX 2.23 3.71E-05 U3J383 Phosphoglucomutase 1 PGM1 2.30 1.06E-07 U3IM27 Aldehyde dehydrogenase 2 family ALDH2 1.50 6.32E-06 U3IE74 Lactate dehydrogenase A LDHA 3.33 5.50E-12 U3IWS8 Hexokinase 2 HK2 2.56 2.22E-02 PPAR signaling pathway A0A0H3U2H5 Stearoyl-CoA desaturase1 SCD1 3.31 4.65E-05 R0LQQ0...”
- Hepatic Proteomic Analysis Reveals That Enhanced Carboxylic Acid Metabolism and Oxidoreduction Promote Muscle and Fat Deposition in Muscovy Duck
Yang, Animals : an open access journal from MDPI 2021 - “...1 7.1 16.6/8.9 93.0/7.4 22 U3IL97 Keratin 12 (KRT12) 123 6 8.4 49.9/5.0 75.0/6.7 23 U3IM27 Aldedh domain-containing protein 141 12 17.1 46.7/5.7 75.0/6.5 38 U3IM27 Aldedh domain-containing protein 314 22 19.9 46.7/5.7 75.0/6.9 24 A0A493TAD1 Eukaryotic translation initiation factor 5A (EIF5A2) 130 5 5.6 15.9/5.5...”
RHA1_RS29865 aldehyde dehydrogenase family protein from Rhodococcus jostii RHA1
32% identity, 79% coverage
- Characterization of key triacylglycerol biosynthesis processes in rhodococci
Amara, Scientific reports 2016 - “...there appears to be no direct homology of tadD in RHA1, three candidates were identified: RHA1_RS29865 , RHA1_RS27320 and RHA1_RS30680 17 . The RNA-seq data indicate that none of these genes were dysregulated under any of the studied conditions ( Table S3 ). Glyceroneogenesis Glyceroneogenesis ensures...”
HISP_04880 aldehyde dehydrogenase from Haloarcula hispanica N601
32% identity, 84% coverage
- Insights into gene regulation of the halovirus His2 infecting Haloarcula hispanica
Lee, MicrobiologyOpen 2020 - “...HISP_01730 METABOLISM Metabolism of cofactors and vitamins CTPdependent riboflavin kinase 0.055 0.401 0.235 0.111 M HISP_04880 METABOLISM Energy production and conversion NADdependent aldehyde dehydrogenases 0.109 0.687 0.769 1.566 M HISP_09835 METABOLISM Lipid transport and metabolism Acylcoenzyme A synthetases/AMP(fatty) acid ligases 1.323 0.339 0.337 1.324 M HISP_16785...”
WP_059211011 aldehyde dehydrogenase from Streptomyces canus
35% identity, 66% coverage
KW89_2719 aldehyde dehydrogenase family protein from Piscirickettsia salmonis
31% identity, 87% coverage
- Analysis of Piscirickettsia salmonis Metabolism Using Genome-Scale Reconstruction, Modeling, and Testing
Cortés, Frontiers in microbiology 2017 - “...AKP74768.1 Glycosyltransferase D6Z995.1| MSHA_SEGRD 30.2 clade G2 KW89_2115 ALA25581.1 Bifunctional acetaldehyde-CoA/alcohol dehydrogenase P0A9Q8.2| ADHE_ECO57 70 KW89_2719 ALA26181.1 Aldehyde dehydrogenase P33008.1| ALDH_PSESP 40 KW89_436 ALA23905.1 Tryptophan dioxygenase Q1CVR6.1| T23O_MYXXD 29 KW89_869 ALA24337.1 dCTP deaminase A4T0X9.1| DCD_MYCGI 32 KW89_2210 ALA25676.1 Cytidine deaminase P19079.1| CDD_BACSU 35 KW89_2962 ALA26421.1 Uncharacterized...”
WP_005473480 aldehyde dehydrogenase from Streptomyces bottropensis ATCC 25435
34% identity, 66% coverage
WP_057613570 aldehyde dehydrogenase from Streptomyces sp. Root369
34% identity, 66% coverage
ligV / A2PZP3 vanillin dehydrogenase monomer (EC 1.2.1.67) from Sphingomonas paucimobilis (see 2 papers)
A2PZP3 vanillin dehydrogenase (EC 1.2.1.67) from Sphingomonas paucimobilis (see paper)
G2IMC6 vanillin dehydrogenase (EC 1.2.1.67) from Sphingobium sp. SYK-6 (see paper)
31% identity, 84% coverage
BMEI0024 L-SORBOSONE DEHYDROGENASE, NAD(P) DEPENDENT from Brucella melitensis 16M
33% identity, 65% coverage
P27463 retinal dehydrogenase (EC 1.2.1.36) from Gallus gallus (see 2 papers)
30% identity, 84% coverage
- Metalloproteomic analysis of liver proteins isolated from broilers fed with different sources and levels of copper and manganese
Aparecida, Scientific reports 2024 - “...6.17/47,305.01 380.7553 High Cu/Mn SO 4 =Mn P07322 ENO3 Beta-enolase 7.28/47,196.08 247.165 High Cu/Mn (OH)Cl=Mn P27463 ALDH1A1 Retinal dehydrogenase 1 7.49/55,809.33 66.4081 10 O93344 ALDH1A2 Retinal dehydrogenase 2 5.87/56,731.99 66.4081 P51913 ENO1 Alpha-enolase 6.65/43,874 6.17/47,305.01 10,775.61 High Cu/Mn SO 4 =CuHigh Cu/Mn (OH)Cl=Cu O57391 ENO2 Gamma-enolase...”
- “...GLUD1 Glutamate dehydrogenase 1, mitochondrial 7.82/51,213 8.48/55,712.06 2828.28 High Cu/Mn SO 4 =Cu e Mn P27463 ALDH1A1 Retinal dehydrogenase 1 7.49/55,809.33 2341.783 P07341 ALDOB Fructose-bisphosphate aldolase B 8.81/39,295.78 299.201 High Cu/Mn (OH)Cl=Cu e Mn O93344 ALDH1A2 Retinal dehydrogenase 2 5.87/56,731.99 155.6904 26 Q5ZJF4 PRDX6 Peroxiredoxin-6 6.65/25,240...”
- Characterization of the Effects of Low-Sodium Salt Substitution on Sensory Quality, Protein Oxidation, and Hydrolysis of Air-Dried Chicken Meat and Its Molecular Mechanisms Based on Tandem Mass Tagging-Labeled Quantitative Proteomics.
Li, Foods (Basel, Switzerland) 2024 - “...transferase A0A3Q2TYR0 MYOZ3 Myozenin 3 E1C312 CAPN6 Calpain 6 A0A8V0YZK6 NMNAT1 Retinol binding protein 7 P27463 ALDH1A1 Aldehyde dehydrogenase 1A1 A0A8V1AEN9 DPP7 Dipeptidyl peptidase 7...”
- Effect of Dietary Betaine on Muscle Protein Deposition, Nucleic Acid and Amino Acid Contents, and Proteomes of Broilers
Chen, Animals : an open access journal from MDPI 2022 - “...1.337 0.046 A0A3Q2U578 Histone H3 N/A 1.205 0.019 A0A1D5NY17 Transmembrane protein 182 TMEM182 1.223 0.033 P27463 Retinal dehydrogenase 1 ALDH1A1 1.502 0.050 P25324 Thiosulfate sulfurtransferase TST 1.259 0.017 Q90579 Anion exchange protein N/A 1.649 0.016 Q5F3G6 PHD finger protein 20-like protein 1 PHF20L1 1.538 0.007 Q8QGU2...”
- Reconstruction of insect hormone pathways in an aquatic firefly, Sclerotia aquatilis (Coleoptera: Lampyridae), using RNA-seq.
Chanchay, PeerJ 2019 - “...O94788 1 0 0 0 P20000 1 0 0 0 P51648 1 0 0 0 P27463 1 0 0 1 K10718 JHAMT 29 Q9NBX5 1 18 9 1 Q9TYP1 1 0 0 0 Q54XD0 1 0 2 0 Q91WU5 1 0 0 0 A2APY7 1 1...”
AL1A1_RABIT / Q8MI17 Aldehyde dehydrogenase 1A1; 3-deoxyglucosone dehydrogenase; ALDH-E1; ALHDII; Aldehyde dehydrogenase family 1 member A1; Aldehyde dehydrogenase, cytosolic; Retinal dehydrogenase 1; RALDH 1; RalDH1; EC 1.2.1.19; EC 1.2.1.28; EC 1.2.1.3; EC 1.2.1.36 from Oryctolagus cuniculus (Rabbit) (see paper)
30% identity, 86% coverage
- function: Cytosolic dehydrogenase that catalyzes the irreversible oxidation of a wide range of aldehydes to their corresponding carboxylic acid (PubMed:12941160). Functions downstream of retinol dehydrogenases and catalyzes the oxidation of retinaldehyde into retinoic acid, the second step in the oxidation of retinol/vitamin A into retinoic acid. This pathway is crucial to control the levels of retinol and retinoic acid, two important molecules which excess can be teratogenic and cytotoxic (By similarity). Also oxidizes aldehydes resulting from lipid peroxidation like (E)-4-hydroxynon-2-enal/HNE, malonaldehyde and hexanal that form protein adducts and are highly cytotoxic. By participating for instance to the clearance of (E)-4- hydroxynon-2-enal/HNE in the lens epithelium prevents the formation of HNE-protein adducts and lens opacification (PubMed:12941160). Functions also downstream of fructosamine-3-kinase in the fructosamine degradation pathway by catalyzing the oxidation of 3-deoxyglucosone, the carbohydrate product of fructosamine 3-phosphate decomposition, which is itself a potent glycating agent that may react with lysine and arginine side-chains of proteins (By similarity). Has also an aminobutyraldehyde dehydrogenase activity and is probably part of an alternative pathway for the biosynthesis of GABA/4-aminobutanoate in midbrain, thereby playing a role in GABAergic synaptic transmission (By similarity).
catalytic activity: an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+) (RHEA:16185)
catalytic activity: all-trans-retinal + NAD(+) + H2O = all-trans-retinoate + NADH + 2 H(+) (RHEA:42080)
catalytic activity: 9-cis-retinal + NAD(+) + H2O = 9-cis-retinoate + NADH + 2 H(+) (RHEA:42084)
catalytic activity: 11-cis-retinal + NAD(+) + H2O = 11-cis-retinoate + NADH + 2 H(+) (RHEA:47132)
catalytic activity: 13-cis-retinal + NAD(+) + H2O = 13-cis-retinoate + NADH + 2 H(+) (RHEA:67332)
catalytic activity: (E)-4-hydroxynon-2-enal + NAD(+) + H2O = (E)-4-hydroxynon-2- enoate + NADH + 2 H(+) (RHEA:67248)
catalytic activity: malonaldehyde + NAD(+) + H2O = 3-oxopropanoate + NADH + 2 H(+) (RHEA:67252)
catalytic activity: hexanal + NAD(+) + H2O = hexanoate + NADH + 2 H(+) (RHEA:67276)
catalytic activity: propanal + NAD(+) + H2O = propanoate + NADH + 2 H(+) (RHEA:67256)
catalytic activity: 3-deoxyglucosone + NAD(+) + H2O = 2-dehydro-3-deoxy-D- gluconate + NADH + 2 H(+) (RHEA:67244)
catalytic activity: acetaldehyde + NAD(+) + H2O = acetate + NADH + 2 H(+) (RHEA:25294)
catalytic activity: benzaldehyde + NAD(+) + H2O = benzoate + NADH + 2 H(+) (RHEA:11840)
catalytic activity: 4-aminobutanal + NAD(+) + H2O = 4-aminobutanoate + NADH + 2 H(+) (RHEA:19105)
subunit: Homotetramer (By similarity). Interacts with PRMT3; the interaction is direct, inhibits ALDH1A1 aldehyde dehydrogenase activity and is independent of the methyltransferase activity of PRMT3 (By similarity).
Q9DD46 retinal dehydrogenase (EC 1.2.1.36) from Gallus gallus (see paper)
NP_990000 aldehyde dehydrogenase family 1 member A3 from Gallus gallus
30% identity, 83% coverage
- The transcriptome of metamorphosing flatfish
Alves, BMC genomics 2016 - “...Thyroid hormone binding Cathepsin H CTSH B2D1T2 Sus scrofa lchead_rep_c18375 lcst_c35788 Retinaldehyde dehydrogenase 3 ALDH6 Q9DD46 Gallus gallus lchead_c4855 lcst_c276 Estrogen receptor alpha - Q2PUG8 Hippoglossus hippoglossus lchead_c11863 Thyroid hormone receptor activity Farnesoid X activated receptor - Q8SPF5 Oryctolagus cuniculus lchead_c38827 Nuclear receptor subfamily 1, group...”
- Raldh3 gene expression pattern in the developing chicken inner ear.
Sánchez-Guardado, The Journal of comparative neurology 2009 (PubMed)- GeneRIF: results showed that Raldh3 expression was the only Raldh gene detected in the developing chick inner ear, where it appears as early as stage 18; during inner ear morphogenesis, Raldh3 expression was predominantly observed in the endolymphatic system
WP_037697438 aldehyde dehydrogenase from Streptomyces scabiei
34% identity, 66% coverage
Q0QHK6 1-pyrroline-5-carboxylate dehydrogenase 2 from Glossina morsitans morsitans
33% identity, 63% coverage
Tery_2599 Aldehyde dehydrogenase (NAD+) from Trichodesmium erythraeum IMS101
31% identity, 82% coverage
WP_062046703 aldehyde dehydrogenase from Streptomyces canus
34% identity, 66% coverage
Q1LBV2 Aldehyde dehydrogenase from Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34)
29% identity, 89% coverage
Q6TH48 Aldehyde dehydrogenase, mitochondrial from Danio rerio
31% identity, 79% coverage
- Comparative genomics, molecular evolution and computational modeling of ALDH1B1 and ALDH2
Jackson, Chemico-biological interactions 2013 - “...13 (ve) 24,853 56,563 na 117 75 68 64 Zebrafish Danio rerio 2b NM_213301 AY398308 Q6TH48 516 5:72,465,28272,486,769 13 (ve) 21,488 56,550 na 117 75 68 64 Zebrafish Danio rerio 2c CAM13323 BX510999 Q7SXU3 516 5:72,441,57672,461,572 13 (ve) 19,997 56,483 na 118 76 69 65 na:...”
- Molecular phenotype of zebrafish ovarian follicle by serial analysis of gene expression and proteomic profiling, and comparison with the transcriptomes of other animals
Knoll-Gellida, BMC genomics 2006 - “...dismutase [Cu-Zn] O73872 22 CATGTCTGAGCTGA 4 AY398308 Dr.4751 aldh2 Mitochondrial aldehyde dehydrogenase 2 family [aldh2l] Q6TH48, Q6NWJ9 10, 11 CATGAACCACTCAA 4 BC050953 Dr.7644 cct2 Chaperonin containing TCP1, subunit 2 (Beta) Q6PBW6 V CATGACACAAAATA 4 BQ263267 Dr.25009 vg1 Vitellogenin 1 Q8JH36, Q8JH37, Q90YN8 I-XI, 17, 1017, 2124...”
CwatDRAFT_0842 Aldehyde dehydrogenase (NAD+) from Crocosphaera watsonii WH 8501
30% identity, 82% coverage
- Bioinformatic evaluation of L-arginine catabolic pathways in 24 cyanobacteria and transcriptional analysis of genes encoding enzymes of L-arginine catabolism in the cyanobacterium Synechocystis sp. PCC 6803
Schriek, BMC genomics 2007 - “...Synechococcus sp. RS 9917 RS9917_06190 RS9917_02041, RS9917_05240 RS9917_02641 Crocosphaera watsonii WH 8501 n.d. CwatDRAFT_5161 CwatDRAFT_0865, CwatDRAFT_0842, CwatDRAFT_0969 Trichodesmium erythraeum IMS 101 TeryDRAFT_4567 TeryDRAFT_3251 TeryDRAFT_2672 TeryDRAFT_3296, TeryDRAFT_3923 Freshwater species Synechococcus elongatus sp. PCC 6301 n.d. Syc0599_c, Syc1466_c Syc1030_d Synechococcus elongatus sp. PCC 7942 n.d. Synpcc7942_0943, Synpcc7942_0031 Synpcc7942_0489...”
- “...Synechococcus sp. RS 9917 n.d. RS9917_02041, RS9917_05240 RS9917_02641 Crocosphaera watsonii WH 8501 CwatDRAFT_0830 CwatDRAFT_5161 CwatDRAFT_0865, CwatDRAFT_0842, CwatDRAFT_0969 Trichodesmium erythraeum IMS 101 TeryDRAFT_2282 TeryDRAFT_3251 TeryDRAFT_2672 TeryDRAFT_3296, TeryDRAFT_3923 Freshwater species Synechococcus elongatus sp. PCC 6301 n.d. Syc0599_c, Syc1466_c Syc1030_d Synechococcus elongatus sp. PCC 7942 n.d. Synpcc7942_0943, Synpcc7942_0031 Synpcc7942_0489...”
AL1A3_MOUSE / Q9JHW9 Retinaldehyde dehydrogenase 3; RALDH-3; RalDH3; Aldehyde dehydrogenase 6; Aldehyde dehydrogenase family 1 member A3; Aldh1a3; EC 1.2.1.36 from Mus musculus (Mouse) (see 7 papers)
Q9JHW9 retinal dehydrogenase (EC 1.2.1.36); aldehyde dehydrogenase [NAD(P)+] (EC 1.2.1.5) from Mus musculus (see 4 papers)
Q3UIA4 Aldehyde dehydrogenase from Mus musculus
NP_444310 retinaldehyde dehydrogenase 3 from Mus musculus
31% identity, 79% coverage
- function: Catalyzes the NAD-dependent oxidation of aldehyde substrates, such as all-trans-retinal and all-trans-13,14-dihydroretinal, to their corresponding carboxylic acids, all-trans-retinoate and all-trans- 13,14-dihydroretinoate, respectively (PubMed:11013254, PubMed:11044606, PubMed:14623956, PubMed:15911617). High specificity for all-trans- retinal as substrate, can also accept acetaldehyde as substrate in vitro but with lower affinity (By similarity). Required for the biosynthesis of normal levels of retinoate in the embryonic ocular and nasal regions; a critical lipid in the embryonic development of the eye and the nasal region (PubMed:14623956).
catalytic activity: retinal + NAD(+) + H2O = retinoate + NADH + 2 H(+) (RHEA:16177)
catalytic activity: all-trans-retinal + NAD(+) + H2O = all-trans-retinoate + NADH + 2 H(+) (RHEA:42080)
catalytic activity: all-trans-13,14-dihydroretinal + NAD(+) + H2O = all-trans- 13,14-dihydroretinoate + NADH + 2 H(+) (RHEA:75119)
subunit: Homotetramer.
disruption phenotype: Mutant mice are born at the expected Mendelian rate, but all die within 10 hours after birth (PubMed:14623956, PubMed:23536097). Lethality is due to respiratory distress, caused by choanal atresia, i.e. the lack of communication between the nasal and oral cavities. Mutant embryos at 11.5 dpc lack detectable retinoic acid in the ventral retina, nasal epithelium and in the nasolacrimal groove. At 14.5 dpc mutant embryos display shortening of the ventral retina associated with lens rotation and persistence of the retrolenticular membrane, indicative of retinoic acid deficiency. Still, at 18.5 dpc the ventral retina appears normal. Embryos at 18.5 dpc lack Harderian glands, and display multiple malformations in the nasal region, including choanal atresia, lack of maxillary sinuses and nasolacrimal ducts (PubMed:14623956). Oral gavage of pregnant females with retinoic acid prevents choanal atresia and other malformations of the nasal region (PubMed:14623956, PubMed:23536097). Females that were fed retinoic acid give birth to pups with malformations of the inner ear vestibular organ, causing repetitive circling behavior with head tilting (PubMed:23536097). Likewise, mice display impaired ability in crossing a beam without slipping and an impaired ability to swim (PubMed:23536097). - The biochemical effects of carotenoids in orange carrots on the colonic proteome in a mouse model of diet-induced obesity
Balbuena, Frontiers in nutrition 2024 - “...dehydrogenase 2 ALDH1A2 Q62148 177.9 177.8 234.4 207.8 1.00 1.32 1.17 0.89 Aldehyde dehydrogenase ALDH1A3 Q3UIA4 33.6 38.8 46.6 39.4 1.16 1.20 1.02 0.85 Retinoid X receptor beta RXRB Q3TWJ1 361.6 359.4 375.1 358.0 0.99 1.04 1.00 0.95 Retinol dehydrogenase 14 (All-trans and 9-cis) RDH14 Q569U9...”
- ALDH1A1 and ALDH1A3 paralogues of aldehyde dehydrogenase 1 control myogenic differentiation of skeletal muscle satellite cells by retinoic acid-dependent and -independent mechanisms.
Steingruber, Cell and tissue research 2023 (PubMed)- GeneRIF: ALDH1A1 and ALDH1A3 paralogues of aldehyde dehydrogenase 1 control myogenic differentiation of skeletal muscle satellite cells by retinoic acid-dependent and -independent mechanisms.
- microRNA-483 Protects Pancreatic β-Cells by Targeting ALDH1A3.
Wang, Endocrinology 2021 - GeneRIF: microRNA-483 Protects Pancreatic beta-Cells by Targeting ALDH1A3.
- ALDH1A3 Coordinates Metabolism With Gene Regulation in Pulmonary Arterial Hypertension.
Li, Circulation 2021 - GeneRIF: ALDH1A3 Coordinates Metabolism With Gene Regulation in Pulmonary Arterial Hypertension.
- CHD7 represses the retinoic acid synthesis enzyme ALDH1A3 during inner ear development.
Yao, JCI insight 2018 - GeneRIF: Study using human SH-SY5Y neuroblastoma and 293T cells and transgenic mouse model show that CHD7 directly regulates expression of retinoic acid synthetic enzyme ALDH1A3. Results indicate that ALDH1A3 acts with CHD7 in a common genetic pathway to regulate inner ear development, providing insights for exploration of the pathogenic mechanisms underlying CHARGE syndrome.
- Aldehyde dehydrogenase 1a3 defines a subset of failing pancreatic β cells in diabetic mice.
Kim-Muller, Nature communications 2016 - GeneRIF: Study in diabetic mice reports the discovery of ALDH1A3 isoform as a biomarker of dysfunctional beta cells.
- Sam68 promotes self-renewal and glycolytic metabolism in mouse neural progenitor cells by modulating Aldh1a3 pre-mRNA 3'-end processing.
La, eLife 2016 - GeneRIF: This study identifies Sam68 as a key regulator of neural progenitor cell self-renewal and establishes a novel link between modulation of ALDH1A3 expression and maintenance of high glycolytic metabolism in the developing cortex.
- Expression of aldehyde dehydrogenase family 1, member A3 in glycogen trophoblast cells of the murine placenta.
Outhwaite, Placenta 2015 (PubMed)- GeneRIF: Data suggest that expression of Aldh1a3/Raldh3 in placenta plays role in differentiation/placentation of glycogen trophoblast cells (junctional zone cells) via production of a local source of retinoic acid.
- Whole-Exome Sequencing in a South American Cohort Links ALDH1A3, FOXN1 and Retinoic Acid Regulation Pathways to Autism Spectrum Disorders.
Moreno-Ramos, PloS one 2015 - GeneRIF: Chromatin immunoprecipitation assay using RarB as the immunoprecipitation target suggests retinoic acid regulation of Aldh1a3 and Foxn1 in mice.
- More
- Effects of Doxorubicin on Extracellular Matrix Regulation in Primary Cardiac Fibroblasts from Mice.
Skaggs, BMC research notes 2023 - “...Q64695 Endothelial protein C receptor 3.3 P13597-2 Isoform 2 of Intercellular adhesion molecule 1 2.5 Q9JHW9 Aldehyde dehydrogenase family 1 member A3 2.4 P48999 Arachidonate 5-lipoxygenase 2.0 P16125 L-lactate dehydrogenase B chain 2.0 Q9CRC6 BLOC-1-related complex subunit 7 1.9 Q62433 Protein NDRG1 1.8 Q5I2A0 Serine protease...”
- Pressure Cycling Technology Assisted Mass Spectrometric Quantification of Gingival Tissue Reveals Proteome Dynamics during the Initiation and Progression of Inflammatory Periodontal Disease.
Bao, Proteomics 2020 - “...2.09E-05 6.76E-03 P31725 Protein S100-A9 18 5.18 1.05E-04 9.45E-03 P08071 Lactotransferrin 17 4.86 9.88E-04 3.01E-02 Q9JHW9 Aldehyde dehydrogenase family 1 member A3 7 4.5 8.42E-04 2.77E-02 P27005 Protein S100-A8 5 4.47 2.96E-04 1.65E-02 P51437 Cathelicidin antimicrobial peptide 2 4.33 1.11E-04 9.45E-03 O08692 Neutrophilic granule protein 9...”
7a6qA / P47895 Crystal structure of human aldehyde dehydrogenase 1a3 in complex with selective nr6 inhibitor compound (see paper)
30% identity, 83% coverage
- Ligands: nicotinamide-adenine-dinucleotide; 3-(2-phenylimidazo[1,2-a]pyridin-6-yl)benzenecarbonitrile (7a6qA)
NP_695212 retinaldehyde dehydrogenase 3 from Rattus norvegicus
30% identity, 79% coverage
Q8K4D8 retinal dehydrogenase (EC 1.2.1.36) from Rattus norvegicus (see paper)
30% identity, 79% coverage
ALDH1A3 / P47895 retinal dehydrogenase 3 (EC 1.2.1.36) from Homo sapiens (see 3 papers)
AL1A3_HUMAN / P47895 Retinaldehyde dehydrogenase 3; RALDH-3; RalDH3; Aldehyde dehydrogenase 6; Aldehyde dehydrogenase family 1 member A3; ALDH1A3; EC 1.2.1.36 from Homo sapiens (Human) (see 9 papers)
P47895 retinal dehydrogenase (EC 1.2.1.36); aldehyde dehydrogenase [NAD(P)+] (EC 1.2.1.5) from Homo sapiens (see 6 papers)
NP_000684 retinaldehyde dehydrogenase 3 isoform 1 from Homo sapiens
30% identity, 79% coverage
- function: Catalyzes the NAD-dependent oxidation of aldehyde substrates, such as all-trans-retinal and all-trans-13,14-dihydroretinal, to their corresponding carboxylic acids, all-trans-retinoate and all-trans- 13,14-dihydroretinoate, respectively (By similarity) (PubMed:27759097). High specificity for all-trans-retinal as substrate, can also accept acetaldehyde as substrate in vitro but with lower affinity (PubMed:27759097). Required for the biosynthesis of normal levels of retinoate in the embryonic ocular and nasal regions; a critical lipid in the embryonic development of the eye and the nasal region (By similarity).
catalytic activity: all-trans-retinal + NAD(+) + H2O = all-trans-retinoate + NADH + 2 H(+) (RHEA:42080)
catalytic activity: retinal + NAD(+) + H2O = retinoate + NADH + 2 H(+) (RHEA:16177)
catalytic activity: all-trans-13,14-dihydroretinal + NAD(+) + H2O = all-trans- 13,14-dihydroretinoate + NADH + 2 H(+) (RHEA:75119)
subunit: Homotetramer. - Integrative Proteomics and Phosphoproteomics Profiling of Symptomatic Accessory Navicular Bone Based on Tandem Mass Tag Technology
Liu, International journal of general medicine 2024 - “...Q9BXX0 0.012466 1.9785209 up EMILIN-2 OS=Homo sapiens (EMILIN2) O95865 0.049441 1.9330814 up Dimethylaminohydrolase 2 (DDAH2) P47895 0.0429335 1.8887229 up Aldehyde dehydrogenase family 1 member A3 (ALDH1A3) A0A7I2V440 0.0317217 1.8025379 up Cathepsin B OS=Homo sapiens (CTSB) Q13797 0.0173361 1.7639402 up Integrin alpha-9 OS=Homo sapiens (ITGA9) P22897 0.0126703...”
- Involvement of ribosomal protein L17 and Y-box binding protein 1 in the assembly of hepatitis C virus potentially via their interaction with the 3' untranslated region of the viral genome.
Liu, Journal of virology 2024 - Thrombospondin 1 Mediates Autophagy Upon Inhibition of the Rho-Associated Protein Kinase Inhibitor.
Catral, Cells 2024 - “...ID Fold Change p -Value 1 Q8NFJ5 Retinoic acid-induced protein 3 GPRC5A 2.199 <0.001 2 P47895 Retinaldehyde dehydrogenase 3 ALDH1A3 2.196 <0.001 3 P37059 17-beta-hydroxysteroid dehydrogenase type 2 HSD17B2 1.922 <0.001 4 Q8IZV5 Retinol dehydrogenase 10 RDH10 1.852 0.010 5 Q92597 Protein NDRG1 NDRG1 1.612 <0.001...”
- ALDH1A3-acetaldehyde metabolism potentiates transcriptional heterogeneity in melanoma.
Lu, Cell reports 2024 - “...sequences of yeast ALD6 (UniProt: P54115 ) and ACS2 (UniProt: P52910) and human ALDH1A3 (UniProt: P47895) and ACSS2 (UniProt: Q9NR19) were retrieved. 121 Disordered N-termini of the human proteins, the first 24 residues of each, were removed to facilitate complex prediction. AlphaFold-Multimer 76 predictions were performed...”
- Characterization of human oxidoreductases involved in aldehyde odorant metabolism.
Boichot, Scientific reports 2023 - “...1) Dihydropteridine reductase P09417 7 (8, 7, 0) Aldehyde dehydrogenase family 1 member A3 (ALDH1A3) P47895 10 (5, 9, 0) Carbonyl reductase [NADPH] 3 O75828 8 (5, 5, 0) 25-Hydroxycholesterol 7-alpha-hydroxylase O75881 4 (3, 7, 0) Aflatoxin B1 aldehyde reductase member 2 (AKR7A2) O43488 6 (3,...”
- LHPP Inhibits the Viability, Migration, and Proliferation of PDAC Cells and Significantly Affects the Expression of SDC1 and S100p.
Xia, Technology in cancer research & treatment 2023 - “...2.131E-03 0.624 1.319E-02 P23229 ITGA6 0.452 3.015E-06 0.988 5.703E-01 P25815 S100P 0.990 7.654E-01 0.661 4.669E-04 P47895 ALDH1A3 0.360 8.545E-08 1.132 1.747E-03 P78504 JAG1 1.008 7.458E-01 1.848 1.091E-05 Q00534 CDK6 0.769 4.082E-04 1.382 9.703E-05 Q14258 TRIM25 0.722 1.178E-03 0.650 4.520E-04 Q6PIU2 NCEH1 0.869 2.592E-04 0.575 1.116E-05 Q96LJ7...”
- Zika Virus Infection of Sertoli Cells Alters Protein Expression Involved in Activated Immune and Antiviral Response Pathways, Carbohydrate Metabolism and Cardiovascular Disease
Rashid, Viruses 2022 - “...2.1 10 4 Q96LM1 LINC00615 Putative uncharacterized protein encoded by LINC00615 2.56 3.0 10 3 P47895 ALDH1A3 Aldehyde dehydrogenase family 1 member A3 2.50 3.4 10 5 3.86 9.7 10 5 1.38 2.9 10 2 P20592 MX2 Interferon-induced GTP-binding protein Mx2 2.48 9.3 10 5 2.98...”
- Quantitative proteomic analysis of aberrant expressed lysine acetylation in gastrointestinal stromal tumors
Wang, Clinical proteomics 2021 - “...P47756 F-actin-capping protein subunit beta OS=Homo sapiens OX=9606 GN=CAPZB PE=1 SV=4 235 1.399 Up 0.022458 P47895 Aldehyde dehydrogenase family 1 member A3 OS=Homo sapiens OX=9606 GN=ALDH1A3 PE=1 SV=2 373 2.773 Up 0.0454 P48163 NADP-dependent malic enzyme OS=Homo sapiens OX=9606 GN=ME1 PE=1 SV=1 60 0.731 Down 0.02706...”
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- METTL3-mediated ALDH m6A methylation regulates the malignant behavior of BMI1+ HNSCC stem cells.
Chen, Oral diseases 2024 (PubMed)- GeneRIF: METTL3-mediated ALDH m[6]A methylation regulates the malignant behavior of BMI1[+] HNSCC stem cells.
- ALDH1A3 promotes invasion and metastasis in triple-negative breast cancer by regulating the plasminogen activation pathway.
Bharadwaj, Molecular oncology 2024 - GeneRIF: ALDH1A3 promotes invasion and metastasis in triple-negative breast cancer by regulating the plasminogen activation pathway.
- ALDH1A3 is the switch that determines the balance of ALDH+ and CD24-CD44+ cancer stem cells, EMT-MET, and glucose metabolism in breast cancer.
Fernando, Oncogene 2024 - GeneRIF: ALDH1A3 is the switch that determines the balance of ALDH[+] and CD24[-]CD44[+] cancer stem cells, EMT-MET, and glucose metabolism in breast cancer.
- MiR-320b aberrant expression enhances the radioresistance of human glioma via upregulated expression of ALDH1A3.
Mao, Aging 2023 - GeneRIF: MiR-320b aberrant expression enhances the radioresistance of human glioma via upregulated expression of ALDH1A3.
- Clinical and genetic analysis further delineates the phenotypic spectrum of ALDH1A3-related anophthalmia and microphthalmia.
Kesim, European journal of human genetics : EJHG 2023 - GeneRIF: Clinical and genetic analysis further delineates the phenotypic spectrum of ALDH1A3-related anophthalmia and microphthalmia.
- Enhanced Sensitivity to ALDH1A3-Dependent Ferroptosis in TMZ-Resistant Glioblastoma Cells.
Wu, Cells 2023 - GeneRIF: Enhanced Sensitivity to ALDH1A3-Dependent Ferroptosis in TMZ-Resistant Glioblastoma Cells.
- Structural and biochemical evidence that ATP inhibits the cancer biomarker human aldehyde dehydrogenase 1A3.
Castellví, Communications biology 2022 - GeneRIF: Structural and biochemical evidence that ATP inhibits the cancer biomarker human aldehyde dehydrogenase 1A3.
- Lactic acidosis promotes aggressive features of cholangiocarcinoma cells via upregulating ALDH1A3 expression through EGFR axis.
Thamrongwaranggoon, Life sciences 2022 (PubMed)- GeneRIF: Lactic acidosis promotes aggressive features of cholangiocarcinoma cells via upregulating ALDH1A3 expression through EGFR axis.
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SXYL_00108 NAD-dependent succinate-semialdehyde dehydrogenase from Staphylococcus xylosus
30% identity, 89% coverage
- Adaptation of Staphylococcus xylosus to Nutrients and Osmotic Stress in a Salted Meat Model
Vermassen, Frontiers in microbiology 2016 - “...29.3 12.9 SXYL_00106 Short-chain dehydrogenase 41.3 29.4 13.9 SXYL_00107 glnA2 Glutamine synthetase 41.7 29.2 15.7 SXYL_00108 Aldehyde dehydrogenase 41.3 29.5 15.4 RESPONSE TO OSMOTIC STRESS SXYL_01536 mscL Large-conductance mechanosensitive channel 0.3 0.2 0.3 Synthesis and accumulation of osmoprotectant SXYL_00488-91 opuCABCD Glycine betaine/carnitine/choline ABC transporter 24.8 *...”
U3IF86 Aldehyde dehydrogenase from Anas platyrhynchos platyrhynchos
30% identity, 83% coverage
Q28EU7 Aldehyde dehydrogenase, mitochondrial from Xenopus tropicalis
30% identity, 78% coverage
- Comparative genomics, molecular evolution and computational modeling of ALDH1B1 and ALDH2
Jackson, Chemico-biological interactions 2013 - “...13 (+ve) 12,479 57,706 na 132 81 69 65 Frog Xenopus tropicalis 2 NM_001004907 CR762336 Q28EU7 521 GL172947:177,785195,692 ^ 13 (+ve) 17,908 57,146 na 125 83 73 69 Zebrafish Danio rerio 2a XP_002662252 a AF260121 Q8QGQ2 516 5:72,536,56572,561,417 13 (ve) 24,853 56,563 na 117 75 68...”
A9EEP5 Aldehyde dehydrogenase family 1 subfamily A3 from Rattus norvegicus
30% identity, 79% coverage
SSDH2_SCHPO / Q9UTM8 Putative succinate-semialdehyde dehydrogenase C139.05 [NADP(+)]; SSDH; EC 1.2.1.16 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
SPAC139.05 succinate-semialdehyde dehydrogenase (predicted) from Schizosaccharomyces pombe
29% identity, 82% coverage
- catalytic activity: succinate semialdehyde + NAD(+) + H2O = succinate + NADH + 2 H(+) (RHEA:13217)
catalytic activity: succinate semialdehyde + NADP(+) + H2O = succinate + NADPH + 2 H(+) (RHEA:13213) - Genetic controls of DNA damage avoidance in response to acetaldehyde in fission yeast
Noguchi, Cell cycle (Georgetown, Tex.) 2017 - “...These are: SPCC550.10 (39% identity, 57% similarity), SPAC139.05 (37% identity, 54% similarity), SPAC1002.12c (36% identity, 53% similarity). SPAC139.05 and...”
- Conserved and Diverged Functions of the Calcineurin-Activated Prz1 Transcription Factor in Fission Yeast
Chatfield-Reed, Genetics 2016 - “...term P -value Gene list Small-molecule catabolic process (GO:0044282) 3.0e 4 SPAC2F3.05c, car1 + , SPAC139.05, SPAC4H3.08, gut2 + , gpd3 + , atd1 + , tms1 + , SPCC1223.09, eno102 + Ion transmembrane transport (GO:0034220) 4.7e 4 gti1 + , tgp1 + , pho1 +...”
- Mfc1 is a novel forespore membrane copper transporter in meiotic and sporulating cells
Beaudoin, The Journal of biological chemistry 2011 - “...SPAC3G9.11c SPAC977.16c SPAC57A7.09 SPAC3G9.13c SPAC139.05 SPAC27D7.10c SPBC1198.01 SPBC1711.08 SPCC364.07 SPAC750.01 SPAC589.02c SPBC119.03 SPAC1B3.03c...”
- Genomic binding profiling of the fission yeast stress-activated MAPK Sty1 and the bZIP transcriptional activator Atf1 in response to H2O2
Eshaghi, PloS one 2010 - “...protein 4 4 SPBC365.12c|ish1 LEA domain protein 5 5 SPAC637.03 conserved fungal protein 6 6 SPAC139.05 succinate-semialdehyde dehydrogenase 7 7 SPAC2F3.05c xylose and arabinose reductase 8 8 SPBC725.03 conserved fungal protein 9 9 SPAC19D5.01|pyp2 tyrosine phosphatase 10 10 SPBC660.05 conserved fungal protein 11 11 SPAC3G6.07 unknown...”
- Expression profiling of S. pombe acetyltransferase mutants identifies redundant pathways of gene regulation
Nugent, BMC genomics 2010 - “...SPAC4H3.03c 2.14 0.000486057 grt1 3.04 7.61E-08 mel1 4.43 2.62E-15 SPAPB15E9.02c 2.17 3.00E-08 SPCC338.18 3.04 7.26E-07 SPAC139.05 4.49 1.53E-09 SPCC794.01c 2.18 0.042343035 SPBPB2B2.18 3.05 1.46E-05 SPCPB16A4.06c 4.53 1.21E-11 SPAC1F8.02c 2.18 3.57E-07 SPCC1322.07c 3.10 9.51E-09 SPBC1289.14 4.61 8.12E-16 SPBC4.01 2.20 9.35E-05 SPCC757.03c 3.11 2.10E-09 ght3 4.72 0.001973142 SPBPB8B6.02c...”
- Global expression changes resulting from loss of telomeric DNA in fission yeast
Mandell, Genome biology 2005 - “...+ Transcription SPBPB21E7.04c Amino acid/derivative metabolism* SPCC1840.12 Transporter* SPBC119.03 Amino acid/derivative metabolism* cta3 + Transporter SPAC139.05 Amino acid metabolism* SPBP4G3.03 Unknown/hypothetical SPBC359.02 Amino acid metabolism* SPBC660.05 Unknown/hypothetical SPACUNK4.17 Carbohydrate metabolism* SPAC25H1.01c Unknown/hypothetical SPBC24C6.09c Carbohydrate metabolism* SPAC29A4.12c Unknown/hypothetical SPAC3G9.11c Carbohydrate metabolism* SPBC19C7.04c Unknown/hypothetical SPAC4H3.03c Carbohydrate metabolism* SPAC15E1.02c...”
- Global gene expression of fission yeast in response to cisplatin
Gatti, Cellular and molecular life sciences : CMLS 2004 - “...similarity to transketolase; putative phosphotransacetylase SPAC139.05 probable succinate semialdehyde dehydrogenase SPAC19G12.09 putative aldose reductase...”
- Global transcriptional responses of fission yeast to environmental stress
Chen, Molecular biology of the cell 2003 - “...SPAC26F1.07 SPBC215.11C SPAC19G12.09 SPAC2F3.05C SPAC22A12.17C SPAC139.05 Signaling and transcriptional ptc4 pyp2 ptc1 SPBC20F10.10 SPCC1322.08 SPAC1E11.03...”
- “...14, January 2003 dehydrogenase encoded by the CESR gene SPAC139.05. A role for this enzyme in the response to stress has been suggested in S. cerevisiae...”
ACIAD1725 hydroxybenzaldehyde dehydrogenase from Acinetobacter sp. ADP1
33% identity, 68% coverage
Smp_022960 putative aldehyde dehydrogenase from Schistosoma mansoni
30% identity, 82% coverage
- The genome of the blood fluke Schistosoma mansoni
Berriman, Nature 2009 - “...Smp_016780 1 tubulin alpha chain, putative Vinblastine A , Colchicine A , Vincristine A , Smp_022960 aldehyde dehydrogenase, putative Disulfiram B Smp_026560 calmodulin, putative Bepridil C Smp_030730 1 tubulin beta chain, putative Colchicine A , Vinblastine A , Vincristine A , Albendazole B , Mebendazole B...”
SPAC9E9.09c aldehyde dehydrogenase from Schizosaccharomyces pombe
O14293 Putative aldehyde dehydrogenase-like protein C9E9.09c from Schizosaccharomyces pombe (strain 972 / ATCC 24843)
31% identity, 80% coverage
- Posttranslational Arginylation Enzyme Arginyltransferase1 Shows Genetic Interactions With Specific Cellular Pathways in vivo
Wiley, Frontiers in physiology 2020 - “...CIA machinery protein Mms19 MET18 MMS19 imt2 SPCC4F11.04c 0.000041484 4.09906 Mannosyltransferase Imt2 CSH1, SUR1 atd1 SPAC9E9.09c 0.000043798 4.08647 Aldehyde dehydrogenase (predicted) ALD5, ALD4, ALD6 ALDH1A2, ALDH1A1, ALDH2, ALDH1B1, ALDH1A3 crf1 SPAC22H10.11c 0.000048624 4.06214 Transcriptional corepressor for ribosomal proteins via TOR signaling pathway Crf1 (predicted) CRF1, IFH1...”
- Genetic controls of DNA damage avoidance in response to acetaldehyde in fission yeast
Noguchi, Cell cycle (Georgetown, Tex.) 2017 - “...the major enzyme required for acetaldehyde detoxification.30 The SPAC9E9.09c protein, which consists of 503 amino acids, showed 55% identity and 72% similarity...”
- “...to ALDH2, the 3 most similar proteins, SPAC9E9.09c, SPAC922.07c, and SPCC550.10 were designated atd1, atd2, and atd3 (putative AceTaldehyde Dehydrogenase),...”
- A metabolic strategy to enhance long-term survival by Phx1 through stationary phase-specific pyruvate decarboxylases in fission yeast
Kim, Aging 2014 - “...metabolism 19 agl1, inv1, SPAC1039.11c, cyc1, cit1, aco1, SPAC3A11.07, SPAC26H5.09c, SPAC3C7.13c, zwf1, SPAC4G9.12, SPACUNK4.10, gut2, SPAC9E9.09c, psd2, tms1, erg25, SPCC191.05c, SPBC800.11 response to stress 12 rds1, tos4, SPBC660.05, SPBC1271.08c, SPCC1739.08c, hri1, SPACUNK4.15, SPAC27D7.11c, sod1, srx1, SPAC11D3.16c, alo1 conjugation / meiosis 13 ste7, mfm1, rgs1, isp4, mei2,...”
- Genome-wide characterization of the phosphate starvation response in Schizosaccharomyces pombe
Carter-O'Connell, BMC genomics 2012 - “...]. Pho7 binding is significantly enriched in the promoters of pho1 + , SPBC8E4.01c, SPBC1271.09, SPAC9E9.09C, SPBPB2B2.05, and SPCC330.06c in no-Pi conditions (Figure 2 ). In the case of pho1 + , SPBC8E4.01c, SPAC9E9.09C, and SPBPB2B2.05 there is enrichment of Pho7 even in high-Pi conditions (when...”
- “...to total counts for each chromosome. Magnified ChIP-Seq profiles for pho1 + , SPBC8E4.01c, SPBC1271.09, SPAC9E9.09c, SPBPB2B.05, and SPCC330.06c are shown. Mock samples lacking the TAP epitope (black) were treated identically to experimental samples. Coordinates are relative to the initial ATG, with gene products identified by...”
- Activation of AP-1-dependent transcription by a truncated translation initiation factor
Jenkins, Eukaryotic cell 2005 - “...SPBC16A3.02c SPAC26F1.04c SPAC5H10.05c SPAC513.06c SPAC186.03 SPAC9E9.09c SPBC4F6.16c SPBC115.03 SPAC1952.08c SPAC1782.01 itt1 pdf1 SPBC725.01 Putative...”
- Proteasome regulation of petite-negativity in fission yeast.
Amberg, bioRxiv : the preprint server for biology 2024 - “...aat1 0.57 0.018 plasma membrane amino acid transmembrane transporter Aat1 P87048 mts4 0.56 0.003 mts4 O14293 SPAC9E9.09c 0.55 0.006 aldehyde dehydrogenase Q9US42 urg3 0.54 0.008 Q9C1W3 erg1 0.53 0.008 squalene monooxygenase Erg1 Q9HDX2 SPAPB1A11.03 0.51 0.026 FMN-dependent alpha-hydroxy acid dehydrogenase P22189 cta3 0.51 0.011 P-type ATPase,...”
ZP_01726360 aldehyde dehydrogenase from Cyanothece sp. CCY 0110
30% identity, 82% coverage
XP_623084 aldehyde dehydrogenase, mitochondrial from Apis mellifera
34% identity, 65% coverage
AL1A1_MOUSE / P24549 Aldehyde dehydrogenase 1A1; 3-deoxyglucosone dehydrogenase; ALDH-E1; ALHDII; Aldehyde dehydrogenase family 1 member A1; Aldehyde dehydrogenase, cytosolic; Retinal dehydrogenase 1; RALDH 1; RalDH1; EC 1.2.1.19; EC 1.2.1.28; EC 1.2.1.3; EC 1.2.1.36 from Mus musculus (Mouse) (see 4 papers)
P24549 retinal dehydrogenase (EC 1.2.1.36) from Mus musculus (see 3 papers)
NP_038495 aldehyde dehydrogenase 1A1 from Mus musculus
31% identity, 85% coverage
- function: Cytosolic dehydrogenase that catalyzes the irreversible oxidation of a wide range of aldehydes to their corresponding carboxylic acid (PubMed:12851412). Functions downstream of retinol dehydrogenases and catalyzes the oxidation of retinaldehyde into retinoic acid, the second step in the oxidation of retinol/vitamin A into retinoic acid (PubMed:12851412). This pathway is crucial to control the levels of retinol and retinoic acid, two important molecules which excess can be teratogenic and cytotoxic (Probable). Also oxidizes aldehydes resulting from lipid peroxidation like (E)-4- hydroxynon-2-enal/HNE, malonaldehyde and hexanal that form protein adducts and are highly cytotoxic. By participating for instance to the clearance of (E)-4-hydroxynon-2-enal/HNE in the lens epithelium prevents the formation of HNE-protein adducts and lens opacification (PubMed:17567582). Functions also downstream of fructosamine-3-kinase in the fructosamine degradation pathway by catalyzing the oxidation of 3-deoxyglucosone, the carbohydrate product of fructosamine 3-phosphate decomposition, which is itself a potent glycating agent that may react with lysine and arginine side-chains of proteins (By similarity). Has also an aminobutyraldehyde dehydrogenase activity and is probably part of an alternative pathway for the biosynthesis of GABA/4-aminobutanoate in midbrain, thereby playing a role in GABAergic synaptic transmission (PubMed:26430123).
catalytic activity: an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+) (RHEA:16185)
catalytic activity: all-trans-retinal + NAD(+) + H2O = all-trans-retinoate + NADH + 2 H(+) (RHEA:42080)
catalytic activity: 9-cis-retinal + NAD(+) + H2O = 9-cis-retinoate + NADH + 2 H(+) (RHEA:42084)
catalytic activity: 11-cis-retinal + NAD(+) + H2O = 11-cis-retinoate + NADH + 2 H(+) (RHEA:47132)
catalytic activity: 13-cis-retinal + NAD(+) + H2O = 13-cis-retinoate + NADH + 2 H(+) (RHEA:67332)
catalytic activity: 4-aminobutanal + NAD(+) + H2O = 4-aminobutanoate + NADH + 2 H(+) (RHEA:19105)
catalytic activity: 3-deoxyglucosone + NAD(+) + H2O = 2-dehydro-3-deoxy-D- gluconate + NADH + 2 H(+) (RHEA:67244)
catalytic activity: (E)-4-hydroxynon-2-enal + NAD(+) + H2O = (E)-4-hydroxynon-2- enoate + NADH + 2 H(+) (RHEA:67248)
catalytic activity: malonaldehyde + NAD(+) + H2O = 3-oxopropanoate + NADH + 2 H(+) (RHEA:67252)
catalytic activity: hexanal + NAD(+) + H2O = hexanoate + NADH + 2 H(+) (RHEA:67276)
catalytic activity: propanal + NAD(+) + H2O = propanoate + NADH + 2 H(+) (RHEA:67256)
catalytic activity: acetaldehyde + NAD(+) + H2O = acetate + NADH + 2 H(+) (RHEA:25294)
catalytic activity: benzaldehyde + NAD(+) + H2O = benzoate + NADH + 2 H(+) (RHEA:11840)
subunit: Homotetramer (By similarity). Interacts with PRMT3; the interaction is direct, inhibits ALDH1A1 aldehyde dehydrogenase activity and is independent of the methyltransferase activity of PRMT3 (By similarity).
disruption phenotype: Mice lacking Aldh1a1, obtained at the expected Mendelian ratio, are viable and fertile without obvious defects in growth or survival (PubMed:12851412). However, they are more sensitive to retinol toxicity and are less efficient at metabolizing excess retinol to retinoic acid/RA (PubMed:12851412). An excess of retinol leads to the accumulation of retinaldehyde in these mice (PubMed:12851412). Enhanced alcohol consumption and preference is also observed in knockout mice (PubMed:26430123). A consistent lenticular opacification is also detected in old mice (PubMed:17567582). - Autism patient-derived SHANK2BY29X mutation affects the development of ALDH1A1 negative dopamine neuron.
Lai, Molecular psychiatry 2024 - GeneRIF: Autism patient-derived SHANK2B[Y29X] mutation affects the development of ALDH1A1 negative dopamine neuron.
- ALDH1A1 and ALDH1A3 paralogues of aldehyde dehydrogenase 1 control myogenic differentiation of skeletal muscle satellite cells by retinoic acid-dependent and -independent mechanisms.
Steingruber, Cell and tissue research 2023 (PubMed)- GeneRIF: ALDH1A1 and ALDH1A3 paralogues of aldehyde dehydrogenase 1 control myogenic differentiation of skeletal muscle satellite cells by retinoic acid-dependent and -independent mechanisms.
- Global Deletion of ALDH1A1 and ALDH1A2 Genes Does Not Affect Viability but Blocks Spermatogenesis.
Topping, Frontiers in endocrinology 2022 - GeneRIF: Global Deletion of ALDH1A1 and ALDH1A2 Genes Does Not Affect Viability but Blocks Spermatogenesis.
- ALDH1A1 overexpression in melanoma cells promotes tumor angiogenesis by activating the IL‑8/Notch signaling cascade.
Ciccone, International journal of molecular medicine 2022 - GeneRIF: ALDH1A1 overexpression in melanoma cells promotes tumor angiogenesis by activating the IL8/Notch signaling cascade.
- Fli1 deficiency suppresses RALDH1 activity of dermal dendritic cells and related induction of regulatory T cells: a possible role in scleroderma.
Miura, Arthritis research & therapy 2021 - GeneRIF: Fli1 deficiency suppresses RALDH1 activity of dermal dendritic cells and related induction of regulatory T cells: a possible role in scleroderma.
- Inhibition of 15-PGDH causes Kras-driven tumor expansion through prostaglandin E2-ALDH1 signaling in the pancreas.
Arima, Oncogene 2019 (PubMed)- GeneRIF: Finally, ATRA replacement suppressed 15-PGDH inhibition-induced tumor progression in KC mice, and ATRA treatment attenuated Aldh1 activity in tumor cells isolated from the pancreas of 15-Pgdh(-/-) KC mice. These findings provide evidence that 15-PGDH inhibition enhances KRAS-driven tumor progression via ATRA depletion in the pancreas. Therefore, ATRA replacement could be a potential strategy for PDAC treatment.
- ALDH1A1 regulates postsynaptic μ-opioid receptor expression in dorsal striatal projection neurons and mitigates dyskinesia through transsynaptic retinoic acid signaling.
Pan, Scientific reports 2019 - GeneRIF: ALDH1A1 regulates postsynaptic mu-opioid receptor expression in dorsal striatal projection neurons and mitigates dyskinesia through transsynaptic retinoic acid signaling.
- A novel reporter construct for screening small molecule inhibitors that specifically target self-renewing cancer cells.
Shanmugam, Experimental cell research 2019 (PubMed)- GeneRIF: A reporter construct for self-renewing cancer stem cells (CSCs), based on ALDH1A1 expression. Oral cancer cells harboring ALDH1A1-DsRed2 were used to screen inhibitors that target CSCs.
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- Proteomics Analysis Provides Insights into the Role of Lipid Metabolism in T2DM-Related Sarcopenia.
Wu, ACS omega 2024 - “...value Upregulated Q99L88 -1-syntrophin Sntb1 11.098 0.000832 Q8R2Y2 cell surface glycoprotein MUC18 Mcam 6.072 0.023704 P24549 retinal dehydrogenase 1 Aldh1a1 4.657 0.002246 Q9R0H0 peroxisomal acyl-coenzyme A oxidase 1 Acox1 4.016 0.000247 P09541 myosin light chain 4 Myl4 3.793 0.000435 Q9D6M3 mitochondrial@2022 glutamate carrier 1 Slc25a22 3.599...”
- Proteomic Analysis Identifies Multiple Mechanisms of 5-Fluorouracil-Induced Gut Mucositis in Mice.
Ivanov, Cancers 2024 - “...kDa subunit, mitochondrial Q91VD9 Ndufs1 2.3 Protein ETHE1, mitochondrial Q9DCM0 Ethe1 6.0 Retinal dehydrogenase 1 P24549 Aldh1a1 2.2 Sulfide:quinone oxidoreductase, mitochondrial Q9R112 Sqor 5.2 UDP-glucose 6-dehydrogenase O70475 Ugdh 12.5 UDP-glucuronosyltransferase 1-7C Q6ZQM8 Ugt1a7 2.4 Proteins up-regulated in the ileum 4-aminobutyrate aminotransferase, mitochondrial P61922 Abat 4.7 Amiloride-sensitive...”
- A Murine Model of Maternal Micronutrient Deficiencies and Gut Inflammatory Host-microbe Interactions in the Offspring.
Holani, Cellular and molecular gastroenterology and hepatology 2024 - “...4.05621400904059E-06 0.005889622741126940 Up-regulated P12787 Cox5a 0.8836041756435050 9.14052870878679E-06 0.013235485570323300 Up-regulated P24270 Cat 1.693930533094730 3.22382719790435E-09 4.7422498081173E-06 Down-regulated P24549 Aldh1a1 1.0447106634966300 1.41518172923822E-05 0.020406920535615200 Down-regulated P28271 Aco1 0.7917686970933590 3.45645356990867E-05 0.04946185058539300 Down-regulated P28843 Dpp4 0.9711436627995890 1.62290410551764E-05 0.023321131996288500 Down-regulated P29758 Oat 0.9232173792610570 4.47535539220895E-06 0.0064892653187029700 Down-regulated P34884 Mif 0.8806908186675840 3.43356753663742E-05 0.0491686871246479 Up-regulated P34914...”
- Redox Proteomic Profile of Tirapazamine-Resistant Murine Hepatoma Cells
Nemeikaitė-Čėnienė, International journal of molecular sciences 2023 - “...3 4 5 6 Upregulated 1 Aldh3a1 P47739 Aldehyde dehydrogenase, dimeric NADP-preferring 5.18 2 Aldh1a1 P24549 Retinaldehyde dehydrogenase 1 4.97 6.00 3 Adh7 Q64437 Alcohol dehydrogenase class 4 mu/sigma chain 4.80 1.16 4 Aldh3b1 Q3TX25 Aldehyde dehydrogenase family 3 member B1 3.43 5 Aldh1a7 B2RTL5 Aldehyde...”
- “...Change in TPZ-Resistant Cells Fold Change in RH1- Resistant Cells [ 36 ] 1 Aldh1a1 P24549 Retinaldehyde dehydrogenase 1 4.97 6.00 2 Aldh3b1 Q3TX25 Aldehyde dehydrogenase family 3 member B1 3.43 3 Gclc P97494 Glutamate-cysteine ligase catalytic subunit 3.40 4 Apoe P08226 Apolipoprotein E OS =...”
- Proteomic profiling of retina and retinal pigment epithelium combined embryonic tissue to facilitate ocular disease gene discovery.
Aryal, Human genetics 2023 - “...Gene Name Uniprot Accession Primary Protein Name Associated Retina or Eye Defects References 1 Aldh1a1 P24549 Retinal dehydrogenase 1 (RALDH 1; RalDH1) Expressed throughout development in dorsal retina; Choroidal hypoplasia in mice ( Fan et al. 2003 ; Goto et al. 2018 ; Duester 2022 )...”
- Decreased Klotho Expression Causes Accelerated Decline of Male Fecundity through Oxidative Injury in Murine Testis.
Wang, Antioxidants (Basel, Switzerland) 2023 - “...1 1.254 B2RTL5; O35945 Ttr Transthyretin 1.140 Q5M9K1; P07309; Q9D6A4 Aldh1a1 Retinal dehydrogenase 1 1.110 P24549 Aldh1b1 Aldehyde dehydrogenase X, mitochondrial 0.844 Q9CZS1 Tpi1 Triosephosphate isomerase 0.679 P17751; P17751-2; H7BXC3 Aldh2 Aldehyde dehydrogenase, mitochondrial 0.610 Q544B1; Q3UJW1; Q3U9J7; P47738; A0A0G2JEU1; Q3U6I3; Q3TVM2 MCODE_4 PPAR signaling pathway...”
- Peptidyl arginine deiminase inhibition alleviates angiotensin II-induced fibrosis.
Ijichi, American journal of translational research 2023 - Proteomic profiling of retina and retinal pigment epithelium combined embryonic tissue to facilitate ocular disease gene discovery.
Aryal, Research square 2023 - “...Gene Name Uniprot Accession Primary Protein Name Associated Retina or Eye Defects Reference 1 Aldh1a1 P24549 Retinal dehydrogenase 1 (RALDH 1; RalDH1) Expressed throughout development in dorsal retina; Choroidal hypoplasia in mice* ( Fan et al. 2003 ; Goto et al. 2018 ; Duester 2022 )...”
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A1S_1110 hydroxybenzaldehyde dehydrogenase from Acinetobacter baumannii ATCC 17978
33% identity, 75% coverage
- Transcriptome profiling in imipenem-selected Acinetobacter baumannii
Chang, BMC genomics 2014 - “...transfer protein A1S_0671 7.89 6.92 Protein tyrosine phosphatase CoA synthase/hydratase/lyase A1S_1109 -0.77 -3.66 Feruloyl-CoA synthase A1S_1110 -0.48 -3.48 Hydroxybenzaldehyde dehydrogenase A1S_1111 -0.41 -4.66 P-hydroxycinnamoyl CoA hydratase/lyase A1S_1112 -0.53 -3.19 Putative 3-hydroxyphenylpropionic transporter MhpT Lipase A1S_1121 4.63 2.24 Lipase/esterase A1S_1122 3.36 0.67 Putative short-chain dehydrogenase A1S_1123 2.77...”
B5X2T3 Aldehyde dehydrogenase, mitochondrial from Salmo salar
30% identity, 79% coverage
XP_002295797 betaine aldehyde dehydrogenase from Thalassiosira pseudonana CCMP1335
30% identity, 80% coverage
praB / C4TP02 2-hydroxymuconate-6-semialdehyde dehydrogenase (EC 1.2.1.85) from Paenibacillus sp. JJ-1b (see paper)
praB / BAH79100.1 2-hydroxymuconate-6-semialdehyde dehydrogenase from Paenibacillus sp. JJ-1b (see paper)
27% identity, 88% coverage
NF2_RS14385 aldehyde dehydrogenase family protein from Nocardia farcinica NBRC 15532
31% identity, 82% coverage
- Characterization of Latex-Clearing Protein and Aldehyde Dehydrogenases Involved in the Utilization of poly(cis-1,4-isoprene) by Nocardia farcinica NBRC 15532
Suzuki, Microorganisms 2022 - “...degradation of oligo-isoprene aldehydes. Based on the enzymatic activity of the ALDH candidates, NF2_RS14000 and NF2_RS14385 may be involved in the degradation of oligo-isoprene aldehydes. Analysis of the reaction products revealed that these ALDHs oxidized tri- to penta-isoprene aldehydes, which were generated by the reaction of...”
- “...in Figure 3 , significant degradation activities were observed for two gene products, NF2_RS14000 and NF2_RS14385. The specific activities of NF2_RS14000 and NF2_RS14385 were 1.2 and 3.9 mU/mg, respectively. These specific activities were comparable to that of GPOL_c02580 (2.1 mU/mg) of strain VH2. Other ALDH candidates,...”
NP_956784 aldehyde dehydrogenase 2 family member, tandem duplicate 1 from Danio rerio
Q7SXU3 Aldehyde dehydrogenase, mitochondrial from Danio rerio
31% identity, 79% coverage
- Accumulation of acetaldehyde in aldh2.1-/- zebrafish causes increased retinal angiogenesis and impaired glucose metabolism.
Wohlfart, Redox biology 2022 - GeneRIF: Accumulation of acetaldehyde in aldh2.1(-/-) zebrafish causes increased retinal angiogenesis and impaired glucose metabolism.
- Comparative genomics, molecular evolution and computational modeling of ALDH1B1 and ALDH2
Jackson, Chemico-biological interactions 2013 - “...13 (ve) 21,488 56,550 na 117 75 68 64 Zebrafish Danio rerio 2c CAM13323 BX510999 Q7SXU3 516 5:72,441,57672,461,572 13 (ve) 19,997 56,483 na 118 76 69 65 na: not available. Gene expression levels for ALDH2 genes are taken from [ 20 ]; Note the presence of...”
MAA_02517 aldehyde dehydrogenase from Metarhizium robertsii ARSEF 23
30% identity, 82% coverage
WP_056264373 aldehyde dehydrogenase from Hydrogenophaga sp. Root209
32% identity, 68% coverage
Q4WPA5 Aldehyde dehydrogenase, putative from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293)
Afu4g08600 aldehyde dehydrogenase, putative from Aspergillus fumigatus Af293
30% identity, 73% coverage
- Identifying Potential Molecular Targets in Fungi Based on (Dis)Similarities in Binding Site Architecture with Proteins of the Human Pharmacolome
Bedoya-Cardona, Molecules (Basel, Switzerland) 2023 - “...Q4WWH7 76 A0A2H0ZYL6 77 G8BAQ2 76 Q5KKP1 77 A0A0D2XNJ1 77 Succinate dehydrogenase P51649 F0U4T1 72.2 Q4WPA5 78 Q6FVP8 81 G8B862 78 Q5K8N2 81 A0A0D2Y168 88 CFTR P13569 F0ULL9 72 Q4WIK7 74 Q6FWS5 79 Q5KL35 78 DPDE4 Q07343 F0UHN7 71.4 FADK 2 Q14289 F0UKJ3 70.8 Q4X028 76...”
- Transcript levels of the Aspergillus fumigatus Cdc42 module, polarisome, and septin genes show little change from dormancy to polarity establishment
Oda, Medical mycology 2017 - “...Afu3g08710 Afu1g14930 Afu6g03050 Afu2g13210 Afu5g03230 Afu4g08600 Afu2g05560 Afu3g11030 Afu2g10420 integral membrane protein, putative antigenic thaumatin...”
- Transcriptomic and proteomic analyses of the Aspergillus fumigatus hypoxia response using an oxygen-controlled fermenter
Barker, BMC genomics 2012 - “...aldehyde dehydrogenase encoding genes in A. fumigatus , Afu2g00720 and Afu7g01000 (NAD + ) and Afu4g08600 and Afu4g13500 (NAD(P) + ), so it is possible that these enzymes, and not AldA, are utilized under hypoxic conditions to metabolize ethanol. Afu4g08600 does show a gradual increase in...”
Bphyt_4023 Aldehyde Dehydrogenase from Burkholderia phytofirmans PsJN
32% identity, 75% coverage
XP_002939310 aldehyde dehydrogenase family 1 member A3 from Xenopus tropicalis
30% identity, 84% coverage
HD73_0368 NADP-dependent succinate-semialdehyde dehydrogenase from Bacillus thuringiensis serovar kurstaki str. HD73
31% identity, 83% coverage
- Identification of metabolism pathways directly regulated by sigma(54) factor in Bacillus thuringiensis
Peng, Frontiers in microbiology 2015 - “...Annotation Fold-change HD73_0366 4-aminobutyrate aminotransferase 9.165 HD73_0367 Sensory box sigma-54 dependent DNA-binding response regulator 2.860 HD73_0368 Succinic semialdehyde dehydrogenase 2.410 HD73_0369 Quaternary ammonium compound-resistance protein 2.377 HD73_0560 Biotin carboxyl carrier protein - HD73_0561 Hypothetical protein - HD73_0562 Amino-acid permease rocC - HD73_1024 Proline racemase 62.621 HD73_1025...”
NCU03415 aldehyde dehydrogenase from Neurospora crassa OR74A
32% identity, 83% coverage
- L-Carnitine Production Through Biosensor-Guided Construction of the Neurospora crassa Biosynthesis Pathway in Escherichia coli
Kugler, Frontiers in bioengineering and biotechnology 2021 - “...N. crassa . TMABADH.1S and TMABADH.1 were derived from NCU00378, and TMABADH.2 was derived from NCU03415. pECXT99A was used as the empty vector control (EV). Means of three replicates are shown. Error bars were calculated by error analysis from the standard deviations of the enzyme assays...”
- Identification and manipulation of Neurospora crassa genes involved in sensitivity to furfural
Feldman, Biotechnology for biofuels 2019 - “...or downregulated when exposed to furfural. Five putative aldehyde dehydrogenase genes met these criteria: NCU03076, NCU03415, NCU09648, NCU00936 and NCU00378. The phenotypic consequences of exposing strains carrying a deletion of each of these predicted aldehyde dehydrogenase genes to 60mM furfural were assessed: one mutant, NCU00378, previously...”
- “...crassa [ 48 ]. Strains carrying deletions of the other identified aldehyde dehydrogenase genes (NCU03076, NCU03415, NCU09648 or NCU00936) did not show a growth phenotype that differed from the wild-type strain when exposed to furfural. The AHD-2 protein is the closest homolog of the mitochondrial aldehyde...”
- Cold Shock as a Screen for Genes Involved in Cold Acclimatization in Neurospora crassa
Watters, G3 (Bethesda, Md.) 2018 - “...Factors NCU04899 17402 dense tricarboxylic acid-15 tca-15 E. coli CS Orth Catalytic Activity Metabolic Process NCU03415 12921 fail aldehyde dehydrogenase CBS-3 E. coli CS Orth NCU11289 23565 fail aldo-keto reductase E. coli CS Orth Catalytic Activity/transporter Activity NCU00097 11110 fail BEAK-1 bek-1 Transc Factors NCU02017 11108...”
- Characterization of indole-3-pyruvic acid pathway-mediated biosynthesis of auxin in Neurospora crassa
Sardar, PloS one 2018 - “...used for bioinformatics as well as for experimental studies were aro-8 (NCU09116), cfp (NCU02193), cbs-3 (NCU03415), ahd-3 (NCU09648), ahd-2 (NCU00378) and mox-2 (NCU03755). Site-specific binding of enzymes to their respective cofactors is essential to determine their active states. The ligand binding sites for the group of...”
- Modulation of Circadian Gene Expression and Metabolic Compensation by the RCO-1 Corepressor of Neurospora crassa
Olivares-Yañez, Genetics 2016 - “...NCU00629 NCU01227 NCU01528 NCU02139 NCU02713 NCU03317 NCU03415 NCU04851 NCU04866 NCU05855 NCU07027 NCU07442 NCU09873 NCU10007 NCU11201 NCU06660 NCU07649...”
- BEM46 shows eisosomal localization and association with tryptophan-derived auxin pathway in Neurospora crassa
Kollath-Leiß, Eukaryotic cell 2014 - “...in N. crassa: NCU09166.7 (tam1), NCU02397.7 (ipd), and NCU03415 (iad1) (see Fig. S3 in the supplemental material). Regulation of transcription of the auxin...”
- The functions of grainy head-like proteins in animals and fungi and the evolution of apical extracellular barriers
Paré, PloS one 2012 - “...important in fungal pea-pathogens for detoxifying host defensive chemicals [58] ; the aldehyde dehydrogenase gene (NCU03415), which encodes a broadly acting detoxification and metabolic enzyme; the genes catalase-3 (NCU00355) (another verified component of the cell wall [46] ) and NAD(P) transhydrogenase (NCU01140), which encode enzymes known...”
- “...following genes: NCU04883 chitinase 1 ; NCU04850 exo-beta-1,3-glucanase ; NCU07787 cerato-platanin ; NCU10051 flavohemoglobin ; NCU03415 aldehyde dehydrogenase ; NCU07821 dimethylaniline monooxygenase ; NCU04533 abundant perithecial protein ; NCU07610 taurine dioxygenase ; NCU07819 alpha-ketoglutarate-dependent taurine dioxygenase ; and NCU07232 heat shock protein 30 . Primer sequences...”
- Differential impact of nutrition on developmental and metabolic gene expression during fruiting body development in Neurospora crassa
Wang, Fungal genetics and biology : FG & B 2012 - “...exoglucanase I precursor (NCU07340), two 60S ribosomal proteins (NCU05804, 00706) and an aldehyde dehydrogenase (NAD+, NCU03415) were significantly down-regulated during late development in SCM samples ( Table S5 ). 3.3. Transcriptional profiling of N. crassa on SCM Growing on SCM, expression patterns for well measured genes...”
- More
P81178 Aldehyde dehydrogenase, mitochondrial from Mesocricetus auratus
29% identity, 86% coverage
NP_001124747 aldehyde dehydrogenase, mitochondrial precursor from Pongo abelii
Q5RF00 Aldehyde dehydrogenase, mitochondrial from Pongo abelii
29% identity, 82% coverage
- Comparative genomics, molecular evolution and computational modeling of ALDH1B1 and ALDH2
Jackson, Chemico-biological interactions 2013 - “...12:112,226,948112,248,403 13 (+ve) * 21,456 56,283 na 124 99 72 68 Orangutan Pongo abelii 2 NP_001124747 na Q5RF00 517 12:113,595,100113,634,788 13 (+ve) 39,689 56,381 na 125 99 72 68 Gibbon Nomascus leucogenys 2 XP_003274503 a na na 517 GL397363:46,368133,282 13 (+ve) 86,915 56,333 na 125 99...”
- Comparative genomics, molecular evolution and computational modeling of ALDH1B1 and ALDH2
Jackson, Chemico-biological interactions 2013 - “...(+ve) * 21,456 56,283 na 124 99 72 68 Orangutan Pongo abelii 2 NP_001124747 na Q5RF00 517 12:113,595,100113,634,788 13 (+ve) 39,689 56,381 na 125 99 72 68 Gibbon Nomascus leucogenys 2 XP_003274503 a na na 517 GL397363:46,368133,282 13 (+ve) 86,915 56,333 na 125 99 71 67...”
HWX41_RS06850 aldehyde dehydrogenase family protein from Bacillus paramycoides
33% identity, 68% coverage
- Genomic Analysis of Endophytic Bacillus cereus T4S and Its Plant Growth-Promoting Traits
Adeleke, Plants (Basel, Switzerland) 2021 - “...acetaldehyde dehydrogenase (acetylating) HWX41_RS13995 dha aldehyde dehydrogenase family protein HWX41_RS19325 dha aldehyde dehydrogenase family protein HWX41_RS06850 dha aldehyde dehydrogenase family protein HWX41_RS10480 dha aldehyde dehydrogenase family protein HWX41_RS13000 dha aldehyde dehydrogenase family protein HWX41_RS17225 dha aldehyde dehydrogenase family protein HWX41_RS17590 dha aldehyde dehydrogenase family protein HWX41_RS14005...”
Q94IC0 betaine-aldehyde dehydrogenase (EC 1.2.1.8) from Hordeum vulgare (see paper)
33% identity, 76% coverage
ALDH2 / P05091 mitochondrial aldehyde dehydrogenase subunit (EC 1.2.1.3; EC 1.2.1.39) from Homo sapiens (see 14 papers)
ALDH2_HUMAN / P05091 Aldehyde dehydrogenase, mitochondrial; ALDH class 2; ALDH-E2; ALDHI; EC 1.2.1.3 from Homo sapiens (Human) (see 3 papers)
P05091 aldehyde dehydrogenase (NAD+) (EC 1.2.1.3) from Homo sapiens (see 13 papers)
NP_000681 aldehyde dehydrogenase, mitochondrial isoform 1 precursor from Homo sapiens
29% identity, 82% coverage
- function: Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage.
catalytic activity: an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+) (RHEA:16185)
subunit: Homotetramer - Potential candidates from a functional food <i>Zanthoxyli Pericarpium</i> (Sichuan pepper) for the management of hyperuricemia: high-through virtual screening, network pharmacology and dynamics simulations
Chen, Frontiers in endocrinology 2024 (no snippet) - Identification of inhibitors from a functional food-based plant Perillae Folium against hyperuricemia via metabolomics profiling, network pharmacology and all-atom molecular dynamics simulations
Wu, Frontiers in endocrinology 2024 - “...ZH02 P08254 MMP3 Intersected target -2151.6 -6.56 ZH03 P21397 MAOA Intersected target -2128.7 -6.49 ZH04 P05091 ALDH2 Intersected target -1975.6 -6.02 ZH05 P45983 MAPK8 Intersected target -2037.3 -6.21 ZH06 Q14790 CASP8 Intersected target -1903.8 -5.8 ZH07 P37231 PPARG Intersected target -1907.6 -5.82 ZH08 Q04206 RELA Intersected...”
- Exploring the effective compounds and potential mechanisms of Shengxian Decoction against coronary heart disease by UPLC-Q-TOF/MS and network pharmacology analysis
Zhou, Heliyon 2024 - “...Gamma-aminobutyric acid type B receptor subunit 1 Q9UBS5 GABBR1 2 0 T95 Aldehyde dehydrogenase, mitochondrial P05091 ALDH2 3 0 T96 Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO 1 0 3.4 C-T-D network construction and CI analysis A C-T-D network was constructed by the Cytoscape 3.8.2 software to facilitate...”
- Novel Genetic and Biochemical Insights into the Spectrum of NEFL-Associated Phenotypes.
Della, Journal of neuromuscular diseases 2024 - “...mitochondrial (CH60_HUMAN) 1.80 0.002 P49821 4 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (NDUV1_HUMAN) 1.79 0.016 P05091 3 Aldehyde dehydrogenase, mitochondrial (ALDH2_HUMAN) 1.79 0.015 P30048 6 Thioredoxin-dependent peroxide reductase, mitochondrial (PRDX3_HUMAN) 1.75 0.013 P00505 17 Aspartate aminotransferase, mitochondrial (AATM_HUMAN) 1.66 0.001 P10412 7 Histone H1.4 (H14_HUMAN) 1.65...”
- UHPLC-Q-Orbitrap HRMS and network analysis to explore the mechanisms of QiShenYiQi dripping pill for treating myocardial infarction.
Liu, Frontiers in pharmacology 2024 - “...receptor A3 4 0.031645643 2.814814815 0.355263158 P04278 SHBG Sex hormone-binding globulin 4 0.031516462 3.055555556 0.327272727 P05091 ALDH2 Aldehyde dehydrogenase 3 0.028014476 3.018518519 0.331288344 P23219 PTGS1 Prostaglandin G/H synthase 1 3 0.050091814 2.685185185 0.372413793 P30542 ADORA1 Adenosine receptor A1 3 0.018871537 2.981481481 0.335403727 P35354 PTGS2 Prostaglandin G/H...”
- Impact of a Functional Dairy Powder and Its Primary Component on the Growth of Pathogenic and Probiotic Gut Bacteria and Human Coronavirus 229E.
Dang, International journal of molecular sciences 2024 - “...motif-containing protein_ mitochondrial 1.09 P12109 COL6A1 Collagen alpha-1chain 1.07 Q12841 FSTL1 Follistatin-related protein 1 1.07 P05091 ALDH2 Aldehyde dehydrogenase_ mitochondrial 1.05 P29966 MARCKS Myristoylated alanine-rich C-kinase substrate 1.05 P06756 ITGAV Integrin alpha V 1.04 Q13308 PTK7 Inactive tyrosine-protein kinase 7 1.04 Q9Y570 PPME1 Protein phosphatase methylesterase...”
- Comparative Proteomic Analysis of Type 2 Diabetic versus Non-Diabetic Vitreous Fluids.
Alanazi, Life (Basel, Switzerland) 2024 - “...Adhesion G protein-coupled receptor B3 ADGRB3 0.015424 4 O60333 Kinesin-like protein KIF1B KIF1B 0.045349 5 P05091 Aldehyde dehydrogenase, mitochondrial ALDH2 0.002538 6 P27487 Dipeptidyl peptidase 4 DPP4 0.049516 7 Q3LXA3 Triokinase/FMN cyclase TKFC 0.034098 8 Q86YR5 G-protein-signaling modulator 1 GPSM1 0.048014 9 Q9UL18 Protein argonaute-1 AGO1...”
- Comparative Proteomic Analysis of Endolymphatic Sac Luminal Fluid in Patients with Meniere's Disease and Controls.
Zhang, Journal of inflammation research 2024 - “...4 P00491 Purine nucleoside phosphorylase PNP 8 4 P62328 Thymosin beta 4 Tmsb4x 7 4 P05091 Aldehyde dehydrogenase 2 ALDH2 6 4 Table 2 A Total of 8 Proteins Were Solely Identified in at Least 7 Out of the 8 Endolymphatic Sac Luminal Fluid Samples of...”
- More
- ALDH2: Essential Mediator for the Remote Ischemic Conditioning Strategy to Reduce Myocardial Ischemia/Reperfusion Injury.
Zhu, Journal of cardiovascular translational research 2024 (PubMed)- GeneRIF: ALDH2: Essential Mediator for the Remote Ischemic Conditioning Strategy to Reduce Myocardial Ischemia/Reperfusion Injury.
- Changes of neurofilament light chain in patients with alcohol dependence following withdrawal and the genetic effect from ALDH2 Polymorphism.
Huang, European archives of psychiatry and clinical neuroscience 2024 - GeneRIF: Changes of neurofilament light chain in patients with alcohol dependence following withdrawal and the genetic effect from ALDH2 Polymorphism.
- Activation of mitochondrial aldehyde dehydrogenase 2 promotes hair growth in human hair follicles.
Lee, Journal of advanced research 2024 - GeneRIF: Activation of mitochondrial aldehyde dehydrogenase 2 promotes hair growth in human hair follicles.
- ALDH2 deficiency exacerbates MCD-diet induced MASLD by modulating bile acid metabolism.
Luo, Free radical biology & medicine 2024 (PubMed)- GeneRIF: ALDH2 deficiency exacerbates MCD-diet induced MASLD by modulating bile acid metabolism.
- Aldehyde Dehydrogenase 2 (ALDH2) rs671 Polymorphism is a Predictor of Pulmonary Hypertension Due to Left Heart Disease.
Tang, Heart, lung & circulation 2024 (PubMed)- GeneRIF: Aldehyde Dehydrogenase 2 (ALDH2) rs671 Polymorphism is a Predictor of Pulmonary Hypertension Due to Left Heart Disease.
- ALDH2 is a novel biomarker and exerts an inhibitory effect on melanoma.
Lei, Scientific reports 2024 - GeneRIF: ALDH2 is a novel biomarker and exerts an inhibitory effect on melanoma.
- Exploring patterns of alcohol use and alcohol use disorder among Asian Americans with a finer lens.
Zhang, Drug and alcohol dependence 2024 (PubMed)- GeneRIF: Exploring patterns of alcohol use and alcohol use disorder among Asian Americans with a finer lens.
- Research Progress on the Correlation between Acetaldehyde Dehydrogenase 2 and Hepatocellular Carcinoma Development.
Yang, The Journal of pharmacology and experimental therapeutics 2024 (PubMed)- GeneRIF: Research Progress on the Correlation between Acetaldehyde Dehydrogenase 2 and Hepatocellular Carcinoma Development.
- More
Q6C2W9 YALI0F04444p from Yarrowia lipolytica (strain CLIB 122 / E 150)
31% identity, 78% coverage
- Proteomic Study of Response to Copper, Cadmium, and Chrome Ion Stress in Yarrowia lipolytica Strains Isolated from Andean Mine Tailings in Peru
Sánchez-Rojas, Microorganisms 2022 - “...modulated upon chromium treatment, such as glycerol-3-phosphate dehydrogenase (Q6CEQ0), isocitrate dehydrogenase [NAD] (Q6CA33), aldehyde dehydrogenase (Q6C2W9), and HSPs. As already reported, Cr +6 can affect the structure and degradation of proteins, as well as DNA, lipids, and other supramolecular biological compounds due to the oxidizing effect...”
- Fatty aldehyde dehydrogenase multigene family involved in the assimilation of n-alkanes in Yarrowia lipolytica
Iwama, The Journal of biological chemistry 2014 - “...and YALI0E00264p (Q6C7J6), YALI0C03025p (Q6CD79), YALI0F04444p (Q6C2W9), YALI0D07942p (Q6C9V7), Hfd1p (Q6C0L0), Hfd2p (Q6C5T1), Hfd3p (Q6CGN3), and Hfd4p...”
Rmet_5544 aldehyde dehydrogenase from Ralstonia metallidurans CH34
31% identity, 67% coverage
Q53FB6 Aldehyde dehydrogenase, mitochondrial (Fragment) from Homo sapiens
29% identity, 82% coverage
Q3UJW1 Aldehyde dehydrogenase, mitochondrial from Mus musculus
29% identity, 82% coverage
For advice on how to use these tools together, see
Interactive tools for functional annotation of bacterial genomes.
The PaperBLAST database links 789,361 different protein sequences to 1,256,019 scientific articles. Searches against EuropePMC were last performed on January 10 2025.
PaperBLAST builds a database of protein sequences that are linked
to scientific articles. These links come from automated text searches
against the articles in EuropePMC
and from manually-curated information from GeneRIF, UniProtKB/Swiss-Prot,
BRENDA,
CAZy (as made available by dbCAN),
BioLiP,
CharProtDB,
MetaCyc,
EcoCyc,
TCDB,
REBASE,
the Fitness Browser,
and a subset of the European Nucleotide Archive with the /experiment tag.
Given this database and a protein sequence query,
PaperBLAST uses protein-protein BLAST
to find similar sequences with E < 0.001.
To build the database, we query EuropePMC with locus tags, with RefSeq protein
identifiers, and with UniProt
accessions. We obtain the locus tags from RefSeq or from MicrobesOnline. We use
queries of the form "locus_tag AND genus_name" to try to ensure that
the paper is actually discussing that gene. Because EuropePMC indexes
most recent biomedical papers, even if they are not open access, some
of the links may be to papers that you cannot read or that our
computers cannot read. We query each of these identifiers that
appears in the open access part of EuropePMC, as well as every locus
tag that appears in the 500 most-referenced genomes, so that a gene
may appear in the PaperBLAST results even though none of the papers
that mention it are open access. We also incorporate text-mined links
from EuropePMC that link open access articles to UniProt or RefSeq
identifiers. (This yields some additional links because EuropePMC
uses different heuristics for their text mining than we do.)
For every article that mentions a locus tag, a RefSeq protein
identifier, or a UniProt accession, we try to select one or two
snippets of text that refer to the protein. If we cannot get access to
the full text, we try to select a snippet from the abstract, but
unfortunately, unique identifiers such as locus tags are rarely
provided in abstracts.
PaperBLAST also incorporates manually-curated protein functions:
- Proteins from NCBI's RefSeq are included if a
GeneRIF
entry links the gene to an article in
PubMed®.
GeneRIF also provides a short summary of the article's claim about the
protein, which is shown instead of a snippet.
- Proteins from Swiss-Prot (the curated part of UniProt)
are included if the curators
identified experimental evidence for the protein's function (evidence
code ECO:0000269). For these proteins, the fields of the Swiss-Prot entry that
describe the protein's function are shown (with bold headings).
- Proteins from BRENDA,
a curated database of enzymes, are included if they are linked to a paper in PubMed
and their full sequence is known.
- Every protein from the non-redundant subset of
BioLiP,
a database
of ligand-binding sites and catalytic residues in protein structures, is included. Since BioLiP itself
does not include descriptions of the proteins, those are taken from the
Protein Data Bank.
Descriptions from PDB rely on the original submitter of the
structure and cannot be updated by others, so they may be less reliable.
(For SitesBLAST and Sites on a Tree, we use a larger subset of BioLiP so that every
ligand is represented among a group of structures with similar sequences, but for
PaperBLAST, we use the non-redundant set provided by BioLiP.)
- Every protein from EcoCyc, a curated
database of the proteins in Escherichia coli K-12, is included, regardless
of whether they are characterized or not.
- Proteins from the MetaCyc metabolic pathway database
are included if they are linked to a paper in PubMed and their full sequence is known.
- Proteins from the Transport Classification Database (TCDB)
are included if they have known substrate(s), have reference(s),
and are not described as uncharacterized or putative.
(Some of the references are not visible on the PaperBLAST web site.)
- Every protein from CharProtDB,
a database of experimentally characterized protein annotations, is included.
- Proteins from the CAZy database of carbohydrate-active enzymes
are included if they are associated with an Enzyme Classification number.
Even though CAZy does not provide links from individual protein sequences to papers,
these should all be experimentally-characterized proteins.
- Proteins from the REBASE database
of restriction enzymes are included if they have known specificity.
- Every protein with an evidence-based reannotation (based on mutant phenotypes)
in the Fitness Browser is included.
- Sequence-specific transcription factors (including sigma factors and DNA-binding response regulators)
with experimentally-determined DNA binding sites from the
PRODORIC database of gene regulation in prokaryotes.
- Putative transcription factors from RegPrecise
that have manually-curated predictions for their binding sites. These predictions are based on
conserved putative regulatory sites across genomes that contain similar transcription factors,
so PaperBLAST clusters the TFs at 70% identity and retains just one member of each cluster.
- Coding sequence (CDS) features from the
European Nucleotide Archive (ENA)
are included if the /experiment tag is set (implying that there is experimental evidence for the annotation),
the nucleotide entry links to paper(s) in PubMed,
and the nucleotide entry is from the STD data class
(implying that these are targeted annotated sequences, not from shotgun sequencing).
Also, to filter out genes whose transcription or translation was detected, but whose function
was not studied, nucleotide entries or papers with more than 25 such proteins are excluded.
Descriptions from ENA rely on the original submitter of the
sequence and cannot be updated by others, so they may be less reliable.
Except for GeneRIF and ENA,
the curated entries include a short curated
description of the protein's function.
For entries from BioLiP, the protein's function may not be known beyond binding to the ligand.
Many of these entries also link to articles in PubMed.
For more information see the
PaperBLAST paper (mSystems 2017)
or the code.
You can download PaperBLAST's database here.
Changes to PaperBLAST since the paper was written:
- November 2023: incorporated PRODORIC and RegPrecise. Many PRODORIC entries were not linked to a protein sequence (no UniProt identifier), so we added this information.
- February 2023: BioLiP changed their download format. PaperBLAST now includes their non-redundant subset. SitesBLAST and Sites on a Tree use a larger non-redundant subset that ensures that every ligand is represented within each cluster. This should ensure that every binding site is represented.
- June 2022: incorporated some coding sequences from ENA with the /experiment tag.
- March 2022: incorporated BioLiP.
- April 2020: incorporated TCDB.
- April 2019: EuropePMC now returns table entries in their search results. This has expanded PaperBLAST's database, but most of the new entries are of low relevance, and the resulting snippets are often just lists of locus tags with annotations.
- February 2018: the alignment page reports the conservation of the hit's functional sites (if available from from Swiss-Prot or UniProt)
- January 2018: incorporated BRENDA.
- December 2017: incorporated MetaCyc, CharProtDB, CAZy, REBASE, and the reannotations from the Fitness Browser.
- September 2017: EuropePMC no longer returns some table entries in their search results. This has shrunk PaperBLAST's database, but has also reduced the number of low-relevance hits.
Many of these changes are described in Interactive tools for functional annotation of bacterial genomes.
PaperBLAST cannot provide snippets for many of the papers that are
published in non-open-access journals. This limitation applies even if
the paper is marked as "free" on the publisher's web site and is
available in PubmedCentral or EuropePMC. If a journal that you publish
in is marked as "secret," please consider publishing elsewhere.
Many important articles are missing from PaperBLAST, either because
the article's full text is not in EuropePMC (as for many older
articles), or because the paper does not mention a protein identifier such as a locus tag, or because of PaperBLAST's heuristics. If you notice an
article that characterizes a protein's function but is missing from
PaperBLAST, please notify the curators at UniProt
or add an entry to GeneRIF.
Entries in either of these databases will eventually be incorporated
into PaperBLAST. Note that to add an entry to UniProt, you will need
to find the UniProt identifier for the protein. If the protein is not
already in UniProt, you can ask them to create an entry. To add an
entry to GeneRIF, you will need an NCBI Gene identifier, but
unfortunately many prokaryotic proteins in RefSeq do not have
corresponding Gene identifers.
References
PaperBLAST: Text-mining papers for information about homologs.
M. N. Price and A. P. Arkin (2017). mSystems, 10.1128/mSystems.00039-17.
Europe PMC in 2017.
M. Levchenko et al (2017). Nucleic Acids Research, 10.1093/nar/gkx1005.
Gene indexing: characterization and analysis of NLM's GeneRIFs.
J. A. Mitchell et al (2003). AMIA Annu Symp Proc 2003:460-464.
UniProt: the universal protein knowledgebase.
The UniProt Consortium (2016). Nucleic Acids Research, 10.1093/nar/gkw1099.
BRENDA in 2017: new perspectives and new tools in BRENDA.
S. Placzek et al (2017). Nucleic Acids Research, 10.1093/nar/gkw952.
The EcoCyc database: reflecting new knowledge about Escherichia coli K-12.
I. M. Keeseler et al (2016). Nucleic Acids Research, 10.1093/nar/gkw1003.
The MetaCyc database of metabolic pathways and enzymes.
R. Caspi et al (2018). Nucleic Acids Research, 10.1093/nar/gkx935.
CharProtDB: a database of experimentally characterized protein annotations.
R. Madupu et al (2012). Nucleic Acids Research, 10.1093/nar/gkr1133.
The carbohydrate-active enzymes database (CAZy) in 2013.
V. Lombard et al (2014). Nucleic Acids Research, 10.1093/nar/gkt1178.
The Transporter Classification Database (TCDB): recent advances
M. H. Saier, Jr. et al (2016). Nucleic Acids Research, 10.1093/nar/gkv1103.
REBASE - a database for DNA restriction and modification: enzymes, genes and genomes.
R. J. Roberts et al (2015). Nucleic Acids Research, 10.1093/nar/gku1046.
Deep annotation of protein function across diverse bacteria from mutant phenotypes.
M. N. Price et al (2016). bioRxiv, 10.1101/072470.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory