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PaperBLAST

PaperBLAST Hits for SwissProt::Q96DC8 Enoyl-CoA hydratase domain-containing protein 3, mitochondrial (Homo sapiens (Human)) (303 a.a., MAAVAVLRAF...)

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Find functional residues: SitesBLAST

Search for conserved domains

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Compare to protein structures

Predict transmenbrane helices: Phobius

Predict protein localization: PSORTb

Find homologs in fast.genomics

Fitness BLAST: loading...

Found 250 similar proteins in the literature:

ECHD3_HUMAN / Q96DC8 Enoyl-CoA hydratase domain-containing protein 3, mitochondrial from Homo sapiens (Human) (see 2 papers)
NP_078969 enoyl-CoA hydratase domain-containing protein 3, mitochondrial precursor from Homo sapiens
100% identity, 100% coverage

Q3MIE0 Enoyl-CoA hydratase domain-containing protein 3, mitochondrial from Rattus norvegicus
82% identity, 99% coverage

LOC118271967 enoyl-CoA hydratase domain-containing protein 3, mitochondrial from Spodoptera frugiperda
52% identity, 82% coverage

XP_022822615 enoyl-CoA hydratase domain-containing protein 3, mitochondrial isoform X1 from Spodoptera litura
52% identity, 82% coverage

CG6984 uncharacterized protein from Drosophila melanogaster
45% identity, 83% coverage

MSMEG_1594 enoyl-CoA hydratase from Mycobacterium smegmatis str. MC2 155
45% identity, 86% coverage

H16_A0810 Enoyl-CoA hydratase/carnithine racemase from Ralstonia eutropha H16
42% identity, 85% coverage

A9762_11445 enoyl-CoA hydratase from Pandoraea sp. ISTKB
44% identity, 82% coverage

BTH_II1717 enoyl-CoA hydratase/isomerase family protein from Burkholderia thailandensis E264
44% identity, 85% coverage

D2SEQ2 Enoyl-CoA hydratase domain-containing protein 3, mitochondrial from Geodermatophilus obscurus (strain ATCC 25078 / DSM 43160 / JCM 3152 / CCUG 61914 / KCC A-0152 / KCTC 9177 / NBRC 13315 / NRRL B-3577 / G-20)
41% identity, 82% coverage

SPO2339, YP_167562 enoyl-CoA hydratase/isomerase family protein from Silicibacter pomeroyi DSS-3
SPO2339 enoyl-CoA hydratase-related protein from Ruegeria pomeroyi DSS-3
36% identity, 69% coverage

CDR20291_0731 3-hydroxybutyryl-CoA dehydratase (crotonase) from Clostridium difficile R20291
35% identity, 80% coverage

CD630_08000, CDR20291_0731 enoyl-CoA hydratase-related protein from Clostridioides difficile 630
35% identity, 80% coverage

Msed_0384 Enoyl-CoA hydratase/isomerase from Metallosphaera sedula DSM 5348
35% identity, 80% coverage

crt1 / A5N5C7 crotonase (EC 4.2.1.150) from Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680) (see paper)
34% identity, 82% coverage

AF0963 enoyl-CoA hydratase (fad-3) from Archaeoglobus fulgidus DSM 4304
32% identity, 83% coverage

TTE0544 Enoyl-CoA hydratase/carnithine racemase from Thermoanaerobacter tengcongensis MB4
36% identity, 81% coverage

MELS_1449 short-chain-enoyl-CoA hydratase from Megasphaera elsdenii DSM 20460
34% identity, 81% coverage

Cbei_4544 enoyl-CoA hydratase/isomerase from Clostridium beijerincki NCIMB 8052
34% identity, 82% coverage

ECHS1 / P30084 short-chain enoyl-CoA hydratase monomer (EC 4.2.1.17) from Homo sapiens (see 7 papers)
ECHM_HUMAN / P30084 Enoyl-CoA hydratase, mitochondrial; mECH; mECH1; Enoyl-CoA hydratase 1; ECHS1; Short-chain enoyl-CoA hydratase; SCEH; EC 4.2.1.17; EC 5.3.3.8 from Homo sapiens (Human) (see 6 papers)
P30084 enoyl-CoA hydratase (EC 4.2.1.17) from Homo sapiens (see 3 papers)
NP_004083 enoyl-CoA hydratase, mitochondrial from Homo sapiens
34% identity, 78% coverage

TGME49_317705 enoyl-CoA hydratase/isomerase family protein from Toxoplasma gondii ME49
32% identity, 65% coverage

ECHM_MOUSE / Q8BH95 Enoyl-CoA hydratase, mitochondrial; mECH; mECH1; Enoyl-CoA hydratase 1; ECHS1; Short-chain enoyl-CoA hydratase; SCEH; EC 4.2.1.17; EC 5.3.3.8 from Mus musculus (Mouse) (see paper)
NP_444349 enoyl-CoA hydratase, mitochondrial precursor from Mus musculus
34% identity, 78% coverage

2hw5C / P30084 The crystal structure of human enoyl-coenzyme a (coa) hydratase short chain 1, echs1
34% identity, 80% coverage

Msed_2001 / A4YI89 3-hydroxypropionyl-CoA dehydratase (EC 4.2.1.116) from Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2) (see 2 papers)
HPCD_METS5 / A4YI89 3-hydroxypropionyl-coenzyme A dehydratase; 3-hydroxypropionyl-CoA dehydratase; EC 4.2.1.116 from Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2) (see paper)
A4YI89 3-hydroxypropionyl-CoA dehydratase (EC 4.2.1.116) from Metallosphaera sedula (see 3 papers)
5zaiC / A4YI89 Crystal structure of 3-hydroxypropionyl-coa dehydratase from metallosphaera sedula (see paper)
WP_012021928 3-hydroxypropionyl-CoA dehydratase from Metallosphaera sedula
Msed_2001 Enoyl-CoA hydratase/isomerase from Metallosphaera sedula DSM 5348
32% identity, 79% coverage

Slip_2089 enoyl-CoA hydratase-related protein from Syntrophothermus lipocalidus DSM 12680
32% identity, 82% coverage

XP_001123353 probable enoyl-CoA hydratase, mitochondrial from Apis mellifera
31% identity, 80% coverage

CBO3202 3-hydroxybutyryl-CoA dehydratase from Clostridium botulinum A str. ATCC 3502
35% identity, 77% coverage

badK / O07453 BadK from Rhodopseudomonas palustris (see paper)
RPA0650 cyclohex-1-ene-1-carboxyl-CoA hydratase from Rhodopseudomonas palustris CGA009
32% identity, 85% coverage

CPF_0090 3-hydroxybutyryl-CoA dehydratase from Clostridium perfringens ATCC 13124
34% identity, 82% coverage

Q1ZXF1 Probable enoyl-CoA hydratase, mitochondrial from Dictyostelium discoideum
32% identity, 80% coverage

CPE0095 crotonase from Clostridium perfringens str. 13
34% identity, 82% coverage

ECHM_RAT / P14604 Enoyl-CoA hydratase, mitochondrial; mECH; mECH1; Enoyl-CoA hydratase 1; ECHS1; Short-chain enoyl-CoA hydratase; SCEH; EC 4.2.1.17; EC 5.3.3.8 from Rattus norvegicus (Rat) (see 6 papers)
P14604 enoyl-CoA hydratase (EC 4.2.1.17); DELTA3,5-DELTA2,4-dienoyl-CoA isomerase (EC 5.3.3.21) from Rattus norvegicus (see 6 papers)
NP_511178 enoyl-CoA hydratase, mitochondrial precursor from Rattus norvegicus
33% identity, 78% coverage

Dred_1781 Enoyl-CoA hydratase/isomerase from Desulfotomaculum reducens MI-1
33% identity, 80% coverage

RPPS3_06600 enoyl-CoA hydratase-related protein from Rhodopseudomonas palustris
32% identity, 85% coverage

1dubA / P14604 2-enoyl-coa hydratase, data collected at 100 k, ph 6.5 (see paper)
33% identity, 78% coverage

Ccar_22780, Ccar_RS22775 short-chain-enoyl-CoA hydratase from Clostridium carboxidivorans P7
32% identity, 84% coverage

RPYSC3_06760 enoyl-CoA hydratase-related protein from Rhodopseudomonas palustris
32% identity, 85% coverage

P34559 Probable enoyl-CoA hydratase, mitochondrial from Caenorhabditis elegans
32% identity, 79% coverage

U3J3G1 Enoyl-CoA hydratase, mitochondrial from Anas platyrhynchos platyrhynchos
33% identity, 91% coverage

GAH_01332 enoyl-CoA hydratase/isomerase family protein from Geoglobus ahangari
29% identity, 82% coverage

ECHS1 / Q58DM8 short chain enoyl-CoA hydratase subunit (EC 4.2.1.150) from Bos taurus (see 5 papers)
NP_001020377 enoyl-CoA hydratase, mitochondrial precursor from Bos taurus
32% identity, 78% coverage

DSY1709 hypothetical protein from Desulfitobacterium hafniense Y51
33% identity, 79% coverage

Rru_A3801 Enoyl-CoA hydratase/isomerase from Rhodospirillum rubrum ATCC 11170
30% identity, 80% coverage

AzCIB_1939 enoyl-CoA hydratase from Azoarcus sp. CIB
33% identity, 78% coverage

PG1079 enoyl-CoA hydratase/isomerase family protein from Porphyromonas gingivalis W83
35% identity, 81% coverage

CNI00240 enoyl-CoA hydratase from Cryptococcus neoformans var. neoformans JEC21
29% identity, 84% coverage

Nmar_1308 Enoyl-CoA hydratase/isomerase from Nitrosopumilus maritimus SCM1
35% identity, 80% coverage

CCNA_00006 enoyl-CoA hydratase from Caulobacter crescentus NA1000
CC0006 enoyl-CoA hydratase/isomerase family protein from Caulobacter crescentus CB15
31% identity, 81% coverage

crt / P52046 crotonase monomer (EC 4.2.1.74; EC 4.2.1.150) from Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787) (see 3 papers)
CRT_CLOAB / P52046 Short-chain-enoyl-CoA hydratase; 3-hydroxybutyryl-CoA dehydratase; Crotonase; EC 4.2.1.150 from Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / IAM 19013 / LMG 5710 / NBRC 13948 / NRRL B-527 / VKM B-1787 / 2291 / W) (see 2 papers)
P52046 short-chain-enoyl-CoA hydratase (EC 4.2.1.150) from Clostridium acetobutylicum (see paper)
crt 3-hydroxybutyryl-CoA dehydratase; EC 4.2.1.55 from Clostridium acetobutylicum (see paper)
CA_C2712 short-chain-enoyl-CoA hydratase from Clostridium acetobutylicum ATCC 824
CAC2712 Crotonase (3-hydroxybutyryl-COA dehydratase) from Clostridium acetobutylicum ATCC 824
34% identity, 78% coverage

PGN_1175 putative enoyl-CoA hydratase from Porphyromonas gingivalis ATCC 33277
35% identity, 81% coverage

acuK / C8YX87 acryloyl-CoA hydratase/3-hydroxypropanoyl-CoA hydrolase (EC 3.1.2.4; EC 4.2.1.116) from Halomonas sp. HTNK1 (see paper)
30% identity, 80% coverage

I6J59_05415 short-chain-enoyl-CoA hydratase from Butyricimonas virosa
33% identity, 80% coverage

Cspa_c04330 short-chain-enoyl-CoA hydratase from Clostridium saccharoperbutylacetonicum N1-4(HMT)
34% identity, 78% coverage

Saci_1109 3-hydroxybutyryl-CoA dehydrogenase from Sulfolobus acidocaldarius DSM 639
32% identity, 37% coverage

CNBH0240 hypothetical protein from Cryptococcus neoformans var. neoformans B-3501A
29% identity, 84% coverage

Q70IM9 Putative enoyl-CoA hydratase I from Pseudomonas sp. Y2
32% identity, 79% coverage

Cbei_2034 3-hydroxybutyryl-CoA dehydratase from Clostridium beijerincki NCIMB 8052
34% identity, 78% coverage

CNAG_04531 enoyl-CoA hydratase from Cryptococcus neoformans var. grubii H99
30% identity, 84% coverage

CIBE_0339, X276_25220 short-chain-enoyl-CoA hydratase from Clostridium beijerinckii NRRL B-598
34% identity, 78% coverage

CBY_3041 3-hydroxybutyryl-CoA dehydratase from Clostridium butyricum 5521
33% identity, 78% coverage

Clocel_2976 short-chain-enoyl-CoA hydratase from Clostridium cellulovorans 743B
32% identity, 80% coverage

PP_2217 enoyl-CoA hydratase/isomerase FadB1x from Pseudomonas putida KT2440
29% identity, 79% coverage

Dred_0401 Enoyl-CoA hydratase/isomerase from Desulfotomaculum reducens MI-1
35% identity, 79% coverage

MAP1017c EchA8_1 from Mycobacterium avium subsp. paratuberculosis str. k10
31% identity, 80% coverage

Q7JR58 Enoyl-CoA hydratase, mitochondrial from Drosophila melanogaster
31% identity, 80% coverage

AUO97_RS14195 enoyl-CoA hydratase-related protein from Acinetobacter baumannii
32% identity, 82% coverage

PFLU3030 putative phenylacetic acid degradation enoyl-CoA hydratase from Pseudomonas fluorescens SBW25
32% identity, 80% coverage

SMc01153 PROBABLE ENOYL COA HYDRATASE PROTEIN from Sinorhizobium meliloti 1021
31% identity, 80% coverage

TTHA1434 3-hydroxybutyryl-CoA dehydratase from Thermus thermophilus HB8
32% identity, 82% coverage

XP_008485588 enoyl-CoA hydratase domain-containing protein 3, mitochondrial-like from Diaphorina citri
49% identity, 40% coverage

A9762_23740 enoyl-CoA hydratase from Pandoraea sp. ISTKB
31% identity, 80% coverage

F502_06297 short-chain-enoyl-CoA hydratase from Clostridium pasteurianum DSM 525 = ATCC 6013
29% identity, 80% coverage

Rv1070c enoyl-CoA hydratase from Mycobacterium tuberculosis H37Rv
30% identity, 80% coverage

AR1Y2_1116 enoyl-CoA hydratase-related protein from Anaerostipes rhamnosivorans
32% identity, 78% coverage

3h81A / P9WNN9 Crystal structure of enoyl-coa hydratase from mycobacterium tuberculosis (see paper)
30% identity, 80% coverage

PFL_3064 enoyl-CoA hydratase/isomerase FadB1x from Pseudomonas fluorescens Pf-5
30% identity, 80% coverage

PHATRDRAFT_55192 hydratase enyol-coa hydratase from Phaeodactylum tricornutum CCAP 1055/1
32% identity, 82% coverage

Q9NEZ8 Enoyl-CoA hydratase, mitochondrial from Caenorhabditis elegans
30% identity, 80% coverage

Ccar_RS01400 short-chain-enoyl-CoA hydratase from Clostridium carboxidivorans P7
31% identity, 82% coverage

Swol_2031 3-hydroxybutyryl-CoA dehydratase from Syntrophomonas wolfei subsp. wolfei str. Goettingen
33% identity, 80% coverage

MAB_2058 Probable enoyl-CoA dehydratase/isomerase from Mycobacterium abscessus ATCC 19977
32% identity, 83% coverage

YdbR / b1393 putative 2,3-dehydroadipyl-CoA hydratase (EC 4.2.1.17) from Escherichia coli K-12 substr. MG1655 (see 7 papers)
PAAF_ECOLI / P76082 2,3-dehydroadipyl-CoA hydratase; Enoyl-CoA hydratase; EC 4.2.1.17 from Escherichia coli (strain K12) (see 4 papers)
P76082 enoyl-CoA hydratase (EC 4.2.1.17) from Escherichia coli (see paper)
NP_415911 putative 2,3-dehydroadipyl-CoA hydratase from Escherichia coli str. K-12 substr. MG1655
b1393 enoyl-CoA hydratase-isomerase from Escherichia coli str. K-12 substr. MG1655
32% identity, 79% coverage

echA mitochondrial enoyl-CoA hydratase from Emericella nidulans (see paper)
32% identity, 85% coverage

X276_16680 short-chain-enoyl-CoA hydratase from Clostridium beijerinckii NRRL B-598
33% identity, 78% coverage

FNP_0790 enoyl-CoA hydratase-related protein from Fusobacterium polymorphum ATCC 10953
32% identity, 82% coverage

GSU1377 3-hydroxybutyryl-CoA dehydratase from Geobacter sulfurreducens PCA
33% identity, 81% coverage

Bd1852 hypothetical protein from Bdellovibrio bacteriovorus HD100
33% identity, 80% coverage

ANACAC_03496 hypothetical protein from Anaerostipes caccae DSM 14662
31% identity, 78% coverage

XNRR2_0150 enoyl-CoA hydratase from Streptomyces albidoflavus
30% identity, 80% coverage

ELI_0538, KR505_10040 enoyl-CoA hydratase-related protein from Eubacterium callanderi
33% identity, 81% coverage

TRIVIDRAFT_87842 uncharacterized protein from Trichoderma virens Gv29-8
30% identity, 85% coverage

CRCH_SYNWW / Q0AVM1 Crotonyl-CoA hydratase; EC 4.2.1.150 from Syntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen) (see paper)
Swol_1936 3-hydroxybutyryl-CoA dehydratase from Syntrophomonas wolfei subsp. wolfei str. Goettingen
33% identity, 78% coverage

CD1057 3-hydroxybutyryl-CoA dehydratase from Clostridium difficile 630
CD630_10570, CDIF630erm_01197 enoyl-CoA hydratase-related protein from Clostridioides difficile 630
31% identity, 82% coverage

ferB2 / Q8RR26 feruloyl-CoA hydratase/lyase from Sphingomonas paucimobilis (see paper)
ferB2 / BAB86296.1 feruloyl-CoA hydratase/lyase from Sphingomonas paucimobilis (see paper)
30% identity, 80% coverage

BP0627 probable enoyl-CoA hydratase/isomerase from Bordetella pertussis Tohama I
33% identity, 81% coverage

BC4524 3-hydroxybutyryl-CoA dehydratase from Bacillus cereus ATCC 14579
30% identity, 83% coverage

acuH / Q5LWT8 acryloyl-CoA hydratase (EC 4.2.1.116) from Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (see 2 papers)
SPO0147, SPO_RS00755 enoyl-CoA hydratase from Ruegeria pomeroyi DSS-3
31% identity, 80% coverage

Saci_1134 hypothetical protein from Sulfolobus acidocaldarius DSM 639
32% identity, 37% coverage

A4U99_15055 enoyl-CoA hydratase-related protein from Flavonifractor plautii
30% identity, 78% coverage

AKT31_ALTAL / Q9P4U9 Enoyl-CoA hydratase AKT3-1; AF-toxin biosynthesis protein 3-1; EC 4.2.1.17 from Alternaria alternata (Alternaria rot fungus) (Torula alternata) (see 4 papers)
35% identity, 80% coverage

PNUC_RS08130 enoyl-CoA hydratase from Polynucleobacter asymbioticus QLW-P1DMWA-1
30% identity, 80% coverage

Psest_2437 Enoyl-CoA hydratase [valine degradation] (EC 4.2.1.17) from Pseudomonas stutzeri RCH2
30% identity, 80% coverage

Tneu_0541 3-hydroxyacyl-CoA dehydrogenase NAD-binding from Thermoproteus neutrophilus V24Sta
Tneu_0541 3-hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase family protein from Pyrobaculum neutrophilum V24Sta
32% identity, 37% coverage

Swol_0790 Enoyl-CoA hydratase/carnithine racemase from Syntrophomonas wolfei subsp. wolfei str. Goettingen
32% identity, 79% coverage

KPHS_23740 enoyl-CoA hydratase-isomerase from Klebsiella pneumoniae subsp. pneumoniae HS11286
32% identity, 80% coverage

FGSG_11295 hypothetical protein from Fusarium graminearum PH-1
31% identity, 83% coverage

H16_A3307 putative enoyl-CoA hydratase from Ralstonia eutropha H16
H16_A3307 enoyl-CoA hydratase from Cupriavidus necator H16
30% identity, 80% coverage

BP1026B_I0261 enoyl-CoA hydratase from Burkholderia pseudomallei 1026b
30% identity, 80% coverage

PA3591 probable enoyl-CoA hydratase/isomerase from Pseudomonas aeruginosa PAO1
Q9HY35 Probable enoyl-CoA hydratase/isomerase from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
31% identity, 81% coverage

WP_071879306 enoyl-CoA hydratase/isomerase family protein from Enterococcus silesiacus
30% identity, 81% coverage

TTX_1028 3-hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase family protein from Thermoproteus tenax Kra 1
32% identity, 36% coverage

SGRA_p0039 enoyl-CoA hydratase-related protein from Saprospira grandis str. Lewin
30% identity, 83% coverage

Q86YB7 Enoyl-CoA hydratase domain-containing protein 2, mitochondrial from Homo sapiens
30% identity, 93% coverage

BAB1_2185 Enoyl-CoA hydratase/isomerase from Brucella melitensis biovar Abortus 2308
32% identity, 82% coverage

D5RAC1 Enoyl-CoA hydratase/isomerase family protein from Fusobacterium nucleatum subsp. nucleatum (strain ATCC 23726 / VPI 4351)
FN1020 3-hydroxybutyryl-CoA dehydratase from Fusobacterium nucleatum subsp. nucleatum ATCC 25586
30% identity, 82% coverage

Afu2g10920 enoyl-CoA hydratase/isomerase family protein from Aspergillus fumigatus Af293
30% identity, 85% coverage

BPHYT_RS17335 2,3-dehydroadipyl-CoA hydratase / enoyl-CoA hydratase (EC 4.2.1.17) from Burkholderia phytofirmans PsJN
30% identity, 80% coverage

BB0763 enoyl CoA dehydratase/isomerase from Bordetella bronchiseptica RB50
30% identity, 81% coverage

AFT31_ALTAL / Q96VB3 Enoyl-CoA hydratase AFT3-1; AF-toxin biosynthesis protein 3-1; EC 4.2.1.17 from Alternaria alternata (Alternaria rot fungus) (Torula alternata) (see 3 papers)
34% identity, 80% coverage

BCAL0409 putative phenylacetic acid degradation enoyl-CoA hydratase PaaF from Burkholderia cenocepacia J2315
31% identity, 80% coverage

BB4614 putative enoyl-CoA hydratase from Bordetella bronchiseptica RB50
30% identity, 80% coverage

Msed_0399 / A4YDS4 crotonyl-CoA hydratase/(S)-3-hydroxybutyryl-CoA dehydrogenase (EC 1.1.1.35; EC 4.2.1.150) from Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2) (see 3 papers)
A4YDS4 3-hydroxybutyryl-CoA dehydrogenase (EC 1.1.1.157); 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35); short-chain-enoyl-CoA hydratase (EC 4.2.1.150) from Metallosphaera sedula (see 2 papers)
Msed_0399 3-hydroxyacyl-CoA dehydrogenase, NAD-binding from Metallosphaera sedula DSM 5348
31% identity, 37% coverage

AFUA_8G01210 enoyl-CoA hydratase/isomerase family protein from Aspergillus fumigatus Af293
30% identity, 80% coverage

BCE_4651 enoyl-CoA hydratase/isomerase family protein from Bacillus cereus ATCC 10987
30% identity, 77% coverage

BP3277 putative enoyl-CoA hydratase from Bordetella pertussis Tohama I
30% identity, 80% coverage

BA2551 enoyl-CoA hydratase/isomerase family protein from Bacillus anthracis str. Ames
33% identity, 80% coverage

BAS4420 enoyl-CoA hydratase/isomerase family protein from Bacillus anthracis str. Sterne
30% identity, 77% coverage

BMEI1945 enoyl-CoA hydratase from Brucella melitensis 16M
32% identity, 82% coverage

RHA1_RS22405 enoyl-CoA hydratase from Rhodococcus jostii RHA1
32% identity, 66% coverage

BAS3322 enoyl-CoA hydratase/isomerase family protein from Bacillus anthracis str. Sterne
30% identity, 80% coverage

SACE_3132 enoyl-CoA hydratase from Saccharopolyspora erythraea NRRL 2338
30% identity, 81% coverage

FP2_20590 enoyl-CoA hydratase-related protein from Faecalibacterium prausnitzii L2-6
30% identity, 79% coverage

PA14_38470 putative enoyl-CoA hydratase from Pseudomonas aeruginosa UCBPP-PA14
Q9I298 3-methylglutaconyl-CoA hydratase from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
PA2013 gamma-carboxygeranoyl-CoA hydratase, GnyH from Pseudomonas aeruginosa PAO1
27% identity, 82% coverage

An02g02820 uncharacterized protein from Aspergillus niger
31% identity, 85% coverage

GK2873 dihydroxynapthoic acid synthetase from Geobacillus kaustophilus HTA426
33% identity, 82% coverage

Q1D5U2 3-hydroxybutyryl-CoA dehydratase from Myxococcus xanthus (strain DK1622)
31% identity, 82% coverage

H281DRAFT_05725 2,3-dehydroadipyl-CoA hydratase / enoyl-CoA hydratase (EC 4.2.1.17) from Paraburkholderia bryophila 376MFSha3.1
29% identity, 80% coverage

H16_A0100 Enoyl-CoA hydratase/carnithine racemase from Ralstonia eutropha H16
29% identity, 77% coverage

Q9I393 Probable enoyl-CoA hydratase/isomerase from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
PA1629 probable enoyl-CoA hydratase/isomerase from Pseudomonas aeruginosa PAO1
31% identity, 79% coverage

D3RXI4 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35); 3-hydroxybutyryl-CoA dehydratase (EC 4.2.1.55) from Ferroglobus placidus (see paper)
31% identity, 36% coverage

YP_555851 enoyl-CoA hydratase from Burkholderia xenovorans LB400
31% identity, 79% coverage

FADB_BACSU / P94549 Probable enoyl-CoA hydratase; EC 4.2.1.17 from Bacillus subtilis (strain 168) (see paper)
BSU28540 enoyl-CoA hydratase from Bacillus subtilis subsp. subtilis str. 168
32% identity, 80% coverage

dcaE / AAL09093.1 DcaE from Acinetobacter baylyi (see 11 papers)
29% identity, 81% coverage

A1S_1111 p-hydroxycinnamoyl CoA hydratase/lyase from Acinetobacter baumannii ATCC 17978
30% identity, 80% coverage

UW3_RS0120745 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase PaaG from Pseudomonas donghuensis
32% identity, 79% coverage

H16_A1885 Enoyl-CoA hydratase/carnithine racemase from Ralstonia eutropha H16
32% identity, 82% coverage

MAP1197 EchA12_2 from Mycobacterium avium subsp. paratuberculosis str. k10
30% identity, 85% coverage

Gbem_0684 methylmalonyl-CoA decarboxylase from Geobacter bemidjiensis Bem
33% identity, 83% coverage

MSMEG_0335 enoyl-CoA hydratase/isomerase from Mycobacterium smegmatis str. MC2 155
31% identity, 81% coverage

ROI_08630 enoyl-CoA hydratase-related protein from Roseburia intestinalis M50/1
31% identity, 78% coverage

HI0968 naphthoate synthase (menB) from Haemophilus influenzae Rd KW20
32% identity, 82% coverage

Q5SLK3 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase (EC 5.3.3.18) from Thermus thermophilus (see paper)
30% identity, 80% coverage

MAB_0606c Probable enoyl-CoA hydratase EchA from Mycobacterium abscessus ATCC 19977
31% identity, 82% coverage

6slbAAA / H9ZNW0 6slbAAA (see paper)
30% identity, 80% coverage

BCG_1533 putative enoyl-CoA hydratase echA12 from Mycobacterium bovis BCG str. Pasteur 1173P2
30% identity, 85% coverage

PAAG_06309 enoyl-CoA hydratase from Paracoccidioides lutzii Pb01
30% identity, 85% coverage

AORI_1505 enoyl-CoA-hydratase DpgD from Amycolatopsis keratiniphila
32% identity, 81% coverage

H16_B0987 enoyl-CoA hydratase/isomerase family protein from Cupriavidus necator H16
H16_B0987 Enoyl-CoA hydratase/isomerase family protein from Ralstonia eutropha H16
31% identity, 80% coverage

A9762_11320 enoyl-CoA hydratase/isomerase family protein from Pandoraea sp. ISTKB
30% identity, 80% coverage

ACTT3_ALTAL / Q589W8 Enoyl-CoA hydratase ACTT3; ACT-toxin biosynthesis protein 3; EC 4.2.1.17 from Alternaria alternata (Alternaria rot fungus) (Torula alternata) (see 5 papers)
33% identity, 80% coverage

DEFDS_1835 3-hydroxybutyryl-CoA dehydratase from Deferribacter desulfuricans SSM1
31% identity, 81% coverage

H16_B0389 Enoyl-CoA hydratase from Ralstonia eutropha H16
H16_B0389 crotonase/enoyl-CoA hydratase family protein from Cupriavidus necator H16
35% identity, 60% coverage

NGR_c37150 enoyl-CoA hydratase from Sinorhizobium fredii NGR234
NGR_c37150 predicted enoyl-CoA hydratase/isomerase family protein from Rhizobium sp. NGR234
30% identity, 80% coverage

VF_1669 1,4-dihydroxy-2-naphthoyl-CoA synthase from Aliivibrio fischeri ES114
34% identity, 82% coverage

Q6CF43 YALI0B10406p from Yarrowia lipolytica (strain CLIB 122 / E 150)
30% identity, 70% coverage

H16_B1773 Enoyl-CoA hydratase/carnithine racemase from Ralstonia eutropha H16
29% identity, 81% coverage

VF_1669 dihydroxynaphthoic acid synthetase from Vibrio fischeri ES114
34% identity, 82% coverage

MENB_SALTY / Q7CQ56 1,4-dihydroxy-2-naphthoyl-CoA synthase; DHNA-CoA synthase; EC 4.1.3.36 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
31% identity, 82% coverage

paaF / Q845K2 2,3-dehydroadipyl-CoA hydratase (EC 4.2.1.17) from Pseudomonas sp. Y2 (see paper)
30% identity, 81% coverage

PP_3283 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase PaaG from Pseudomonas putida KT2440
PP3283 enoyl-CoA hydratase/isomerase PhaB from Pseudomonas putida KT2440
30% identity, 81% coverage

PADG_01209 uncharacterized protein from Paracoccidioides brasiliensis Pb18
C1G2P3 Enoyl-CoA hydratase from Paracoccidioides brasiliensis (strain Pb18)
30% identity, 82% coverage

VC1973 naphthoate synthase from Vibrio cholerae O1 biovar eltor str. N16961
34% identity, 82% coverage

AOC05_11215 enoyl-CoA hydratase from Arthrobacter alpinus
28% identity, 80% coverage

FQU82_01642 enoyl-CoA hydratase from Acinetobacter baumannii
28% identity, 79% coverage

Gmet_2071 Enoyl-CoA hydratase/isomerase from Geobacter metallireducens GS-15
Q39TX4 Enoyl-CoA hydratase/isomerase from Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)
31% identity, 81% coverage

S2475 dihydroxynaphtoic acid synthetase from Shigella flexneri 2a str. 2457T
SF5M90T_2274 1,4-dihydroxy-2-naphthoyl-CoA synthase from Shigella flexneri 5a str. M90T
31% identity, 82% coverage

VPARA_05530 enoyl-CoA hydratase/isomerase family protein from Variovorax paradoxus
32% identity, 81% coverage

G8E09_11740 enoyl-CoA hydratase from Acinetobacter pittii
28% identity, 79% coverage

MenB / b2262 1,4-dihydroxy-2-naphthoyl-CoA synthase (EC 4.1.3.36) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
menB / P0ABU0 1,4-dihydroxy-2-naphthoyl-CoA synthase (EC 4.1.3.36) from Escherichia coli (strain K12) (see 5 papers)
MENB_ECOLI / P0ABU0 1,4-dihydroxy-2-naphthoyl-CoA synthase; DHNA-CoA synthase; EC 4.1.3.36 from Escherichia coli (strain K12) (see 5 papers)
4i42A / P0ABU0 E.Coli. 1,4-dihydroxy-2-naphthoyl coenzyme a synthase (ecmenb) in complex with 1-hydroxy-2-naphthoyl-coa (see paper)
menB / GB|AAC75322.1 Naphthoate synthase; EC 4.1.3.36 from Escherichia coli (see 4 papers)
menB / AAA23682.1 DHNA synthase from Escherichia coli (see paper)
NP_416765 1,4-dihydroxy-2-naphthoyl-CoA synthase from Escherichia coli str. K-12 substr. MG1655
b2262 naphthoate synthase from Escherichia coli str. K-12 substr. MG1655
31% identity, 82% coverage

CG8778 uncharacterized protein from Drosophila melanogaster
29% identity, 90% coverage

Rv1472 enoyl-CoA hydratase from Mycobacterium tuberculosis H37Rv
MT1518 enoyl-CoA hydratase from Mycobacterium tuberculosis CDC1551
29% identity, 85% coverage

T1E_5590 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase PaaG from Pseudomonas putida DOT-T1E
30% identity, 81% coverage

PP_3284 enoyl-CoA hydratase/isomerase from Pseudomonas putida KT2440
30% identity, 80% coverage

BAB2_1046 Enoyl-CoA hydratase/isomerase from Brucella melitensis biovar Abortus 2308
32% identity, 82% coverage

bhn_I2225 enoyl-CoA hydratase-related protein from Butyrivibrio hungatei
28% identity, 80% coverage

F4JML5 methylglutaconyl-CoA hydratase (EC 4.2.1.18) from Arabidopsis thaliana (see paper)
28% identity, 81% coverage

BPSL3043 probable enoyl-CoA hydratase PaaG from Burkholderia pseudomallei K96243
29% identity, 80% coverage

EGO55_13545 enoyl-CoA hydratase/isomerase family protein from Caenibius tardaugens NBRC 16725
31% identity, 81% coverage

SSO1311 Enoyl CoA hydratase (paaF-3) from Sulfolobus solfataricus P2
29% identity, 86% coverage

Igni_1058 3-hydroxyacyl-CoA dehydrogenase, NAD-binding from Ignicoccus hospitalis KIN4/I
29% identity, 35% coverage

menB / P73495 naphthoyl-CoA synthase (EC 4.1.3.36) from Synechocystis sp. (strain PCC 6803 / Kazusa) (see paper)
P73495 1,4-dihydroxy-2-naphthoyl-CoA synthase (EC 4.1.3.36) from Synechocystis sp. (see 2 papers)
4i4zA / P73495 Synechocystis sp. Pcc 6803 1,4-dihydroxy-2-naphthoyl-coenzyme a synthase (menb) in complex with salicylyl-coa (see paper)
sll1127 naphthoate synthase from Synechocystis sp. PCC 6803
32% identity, 82% coverage

DPGD_AMYOR / G4V4T7 Enoyl-CoA-hydratase; EC 4.2.1.17 from Amycolatopsis orientalis (Nocardia orientalis) (see paper)
29% identity, 81% coverage

Saci_2208 3-hydroxybutyryl-CoA dehydrogenase from Sulfolobus acidocaldarius DSM 639
32% identity, 38% coverage

CBG09979 Protein CBG09979 from Caenorhabditis briggsae
32% identity, 71% coverage

H16_B0382 Enoyl-CoA hydratase from Ralstonia eutropha H16
27% identity, 81% coverage

F1NSS6 Enoyl-CoA hydratase domain containing 2 from Gallus gallus
29% identity, 81% coverage

ECI3_MOUSE / Q78JN3 Enoyl-CoA delta isomerase 3, peroxisomal; Delta(3),delta(2)-enoyl-CoA isomerase; D3,D2-enoyl-CoA isomerase; Dodecenoyl-CoA isomerase; EC 5.3.3.8 from Mus musculus (Mouse) (see paper)
Q78JN3 DELTA3-DELTA2-enoyl-CoA isomerase (EC 5.3.3.8) from Mus musculus (see paper)
NP_081223 enoyl-CoA delta isomerase 3, peroxisomal isoform 1 from Mus musculus
29% identity, 74% coverage

SYN_RS09150 enoyl-CoA hydratase/isomerase family protein from Syntrophus aciditrophicus SB
32% identity, 72% coverage

Gmet_2057 Enoyl-CoA hydratase/isomerase from Geobacter metallireducens GS-15
33% identity, 81% coverage

SS1G_00237 hypothetical protein from Sclerotinia sclerotiorum 1980 UF-70
27% identity, 86% coverage

AUO97_RS06660 enoyl-CoA hydratase from Acinetobacter baumannii
27% identity, 82% coverage

H16_A0179 enoyl-CoA hydratase/isomerase family protein from Cupriavidus necator H16
H16_A0179 Enoyl-CoA hydratase/carnithine racemase from Ralstonia eutropha H16
28% identity, 80% coverage

S5LPF1 Enoyl-CoA hydratase/aldolase (Fragment) from Streptomyces sp. V-1
30% identity, 85% coverage

FQU82_00193 enoyl-CoA hydratase from Acinetobacter baumannii
26% identity, 82% coverage

ST0048 254aa long hypothetical enoyl-CoA hydratase from Sulfolobus tokodaii str. 7
30% identity, 80% coverage

ScpB / b2919 methylmalonyl-CoA decarboxylase from Escherichia coli K-12 substr. MG1655 (see 5 papers)
scpB / P52045 methylmalonyl-CoA decarboxylase from Escherichia coli (strain K12) (see 4 papers)
SCPB_ECOLI / P52045 Methylmalonyl-CoA decarboxylase; MMCD; Transcarboxylase; EC 4.1.1.- from Escherichia coli (strain K12) (see 2 papers)
1ef9A / P52045 The crystal structure of methylmalonyl coa decarboxylase complexed with 2s-carboxypropyl coa (see paper)
b2919 putative enzyme from Escherichia coli str. K-12 substr. MG1655
32% identity, 77% coverage

AKT32_ALTAL / Q9P4U7 Enoyl-CoA hydratase AKT3-2; AK-toxin biosynthesis protein 3-2; EC 4.2.1.17 from Alternaria alternata (Alternaria rot fungus) (Torula alternata) (see 4 papers)
33% identity, 80% coverage

BMEII1021 ENOYL-COA HYDRATASE from Brucella melitensis 16M
29% identity, 85% coverage

STM0070 carnitine racemase from Salmonella typhimurium LT2
31% identity, 80% coverage

ECH_THET8 / Q5SKU3 Putative enoyl-CoA hydratase; TtECH; EC 4.2.1.17 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
29% identity, 79% coverage

2uzfA / Q5HH38 Crystal structure of staphylococcus aureus 1,4-dihydroxy-2-naphthoyl coa synthase (menb) in complex with acetoacetyl coa (see paper)
30% identity, 82% coverage

CA265_RS09125 Methylglutaconyl-CoA hydratase (EC 4.2.1.18) from Pedobacter sp. GW460-11-11-14-LB5
29% identity, 80% coverage

lpp0932 hypothetical protein from Legionella pneumophila str. Paris
30% identity, 80% coverage

Q816H9 1,4-dihydroxy-2-naphthoyl-CoA synthase from Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711)
BC4853 Naphthoate synthase from Bacillus cereus ATCC 14579
32% identity, 82% coverage

O34893 Putative enoyl-CoA hydratase/isomerase YngF from Bacillus subtilis (strain 168)
BSU18220 enoyl-CoA hydratase from Bacillus subtilis subsp. subtilis str. 168
29% identity, 79% coverage

YaaL / b0036 crotonobetainyl-CoA hydratase (EC 4.2.1.149) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
caiD / P31551 crotonobetainyl-CoA hydratase (EC 4.2.1.149) from Escherichia coli (strain K12) (see 2 papers)
CAID_ECOLI / P31551 Carnitinyl-CoA dehydratase; Crotonobetainyl-CoA hydratase; EC 4.2.1.149 from Escherichia coli (strain K12) (see paper)
P31551 crotonobetainyl-CoA hydratase (EC 4.2.1.149) from Escherichia coli (see 2 papers)
caiD carnitinyl-CoA dehydratase; EC 4.2.1.- from Escherichia coli K12 (see 5 papers)
b0036 crotonobetainyl CoA hydratase from Escherichia coli str. K-12 substr. MG1655
31% identity, 80% coverage

ECH20_RHOJR / Q0S7P8 (7aS)-7a-methyl-1,5-dioxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA hydrolase; HIEC-CoA hydrolase; EC 4.1.99.- from Rhodococcus jostii (strain RHA1) (see paper)
30% identity, 73% coverage

AWY96_RS24510 2,3-dehydroadipyl-CoA hydratase PaaF from Serratia plymuthica
32% identity, 80% coverage

SMc01641 PUTATIVE ENOYL-COA HYDRATASE PROTEIN from Sinorhizobium meliloti 1021
29% identity, 83% coverage

A1WF10 Short chain enoyl-CoA hydratase from Verminephrobacter eiseniae (strain EF01-2)
30% identity, 80% coverage

SPA0071 carnitine racemase from Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
SC0064 carnitine racemase from Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67
31% identity, 80% coverage

G8E09_11775 enoyl-CoA hydratase from Acinetobacter pittii
27% identity, 81% coverage

SERP0632 naphthoate synthase from Staphylococcus epidermidis RP62A
29% identity, 83% coverage

LIC_12495 enoyl-CoA hydratase-related protein from Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130
28% identity, 78% coverage

MENB_ARATH / Q8GYN9 1,4-dihydroxy-2-naphthoyl-CoA synthase, peroxisomal; DHNS; Enoyl-CoA hydratase/isomerase D; ECHID; Naphthoate synthase; EC 4.1.3.36 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
NP_176255 enoyl-CoA hydratase/isomerase D from Arabidopsis thaliana
AT1G60550 ECHID (ENOYL-COA HYDRATASE/ISOMERASE D); catalytic/ naphthoate synthase from Arabidopsis thaliana
30% identity, 73% coverage

blr3445 blr3445 from Bradyrhizobium japonicum USDA 110
32% identity, 81% coverage

GAH_00487 3-hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase family protein from Geoglobus ahangari
28% identity, 38% coverage

bamR / Q2LXU6 cyclohexa-1,5-dienecarbonyl-CoA hydratase monomer (EC 4.2.1.100) from Syntrophus aciditrophicus (strain SB) (see paper)
SYN_01653 putative enoyl-CoA hydratase from Syntrophus aciditrophicus SB
SYN_RS14220 enoyl-CoA hydratase/isomerase family protein from Syntrophus aciditrophicus SB
27% identity, 82% coverage

MENB_STAAC / Q5HH38 1,4-dihydroxy-2-naphthoyl-CoA synthase; DHNA-CoA synthase; EC 4.1.3.36 from Staphylococcus aureus (strain COL) (see 2 papers)
NWMN_0915 naphthoate synthase from Staphylococcus aureus subsp. aureus str. Newman
SAOUHSC_00985 enoyl-CoA hydratase/isomerase family protein, putative from Staphylococcus aureus subsp. aureus NCTC 8325
SAUSA300_0948 naphthoate synthase from Staphylococcus aureus subsp. aureus USA300_FPR3757
SACOL1054 naphthoate synthase from Staphylococcus aureus subsp. aureus COL
SAA6008_01000, SAPIG1043 1,4-dihydroxy-2-naphthoyl-CoA synthase from Staphylococcus aureus subsp. aureus str. JKD6008
29% identity, 82% coverage

DMB42_RS42710 enoyl-CoA-hydratase DpgD from Nonomuraea sp. WAC 01424
29% identity, 81% coverage

SA0898 naphthoate synthase from Staphylococcus aureus subsp. aureus N315
29% identity, 82% coverage

LOC118264501 methylglutaconyl-CoA hydratase, mitochondrial from Spodoptera frugiperda
26% identity, 79% coverage

H16_A3593 / Q0K5S0 enoyl-CoA hydratase (EC 4.2.1.17) from Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) (see paper)
H16_A3593 Enoyl-CoA hydratase from Ralstonia eutropha H16
28% identity, 81% coverage

EUBREC_1017 3-hydroxybutyryl-coA dehydratase from Eubacterium rectale ATCC 33656
30% identity, 83% coverage

bbsH / Q9KJE7 (2S)-2-[(R)-hydroxybenzyl]succinyl-CoA monomer (EC 4.2.1.180) from Thauera aromatica (see 2 papers)
BBSH_THAAR / Q9KJE7 (E)-benzylidenesuccinyl-CoA hydratase; EC 4.2.1.180 from Thauera aromatica (see 2 papers)
30% identity, 83% coverage

FRAAL4765 Putative enoyl-CoA hydratase from Frankia alni ACN14a
33% identity, 30% coverage

rrnAC0833 enoyl-CoA hydratase from Haloarcula marismortui ATCC 43049
31% identity, 81% coverage

ech / CAC18324.1 enoyl-CoA hydratase/aldolase from Amycolatopsis sp. HR167 (see paper)
29% identity, 85% coverage

Pf6N2E2_2193 Methylglutaconyl-CoA hydratase (EC 4.2.1.18) from Pseudomonas fluorescens FW300-N2E2
26% identity, 82% coverage

NP_001009275 enoyl-Coenzyme A delta isomerase 3 from Rattus norvegicus
28% identity, 69% coverage

SCO4930 enoyl-CoA hydratase from Streptomyces coelicolor A3(2)
30% identity, 81% coverage

SSO2017 Enoyl CoA hydratase (paaF-4) from Sulfolobus solfataricus P2
28% identity, 86% coverage

AO356_01590 Methylglutaconyl-CoA hydratase (EC 4.2.1.18) from Pseudomonas fluorescens FW300-N2C3
26% identity, 82% coverage

FN0271 Enoyl-CoA hydratase from Fusobacterium nucleatum subsp. nucleatum ATCC 25586
30% identity, 82% coverage

CTCNB1_RS06525 enoyl-CoA hydratase from Comamonas thiooxydans
30% identity, 67% coverage

CC1_14660 enoyl-CoA hydratase-related protein from Coprococcus catus GD/7
31% identity, 78% coverage

ANACAC_00255 hypothetical protein from Anaerostipes caccae DSM 14662
31% identity, 78% coverage

Fer4 / Q4PEN0 methylglutaconyl-CoA hydratase (EC 4.2.1.18) from Ustilago maydis (strain 521 / FGSC 9021) (see 2 papers)
FER4_USTMA / Q4PEN0 Enoyl-CoA isomerase/hydratase fer4; Fe-regulated protein 4; Ferrichrome A biosynthesis protein fer4; EC 4.2.1.17 from Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus) (see 2 papers)
UMAG_01433 uncharacterized protein from Ustilago maydis 521
28% identity, 83% coverage

BQ2027_MB3408 enoyl-CoA hydratase/isomerase family protein from Mycobacterium tuberculosis variant bovis AF2122/97
30% identity, 79% coverage

SGO_1700 enoyl-CoA hydratase/isomerase family protein from Streptococcus gordonii str. Challis substr. CH1
28% identity, 81% coverage

New Search

For advice on how to use these tools together, see Interactive tools for functional annotation of bacterial genomes.

Statistics

The PaperBLAST database links 784,739 different protein sequences to 1,253,012 scientific articles. Searches against EuropePMC were last performed on November 25 2024.

How It Works

PaperBLAST builds a database of protein sequences that are linked to scientific articles. These links come from automated text searches against the articles in EuropePMC and from manually-curated information from GeneRIF, UniProtKB/Swiss-Prot, BRENDA, CAZy (as made available by dbCAN), BioLiP, CharProtDB, MetaCyc, EcoCyc, TCDB, REBASE, the Fitness Browser, and a subset of the European Nucleotide Archive with the /experiment tag. Given this database and a protein sequence query, PaperBLAST uses protein-protein BLAST to find similar sequences with E < 0.001.

To build the database, we query EuropePMC with locus tags, with RefSeq protein identifiers, and with UniProt accessions. We obtain the locus tags from RefSeq or from MicrobesOnline. We use queries of the form "locus_tag AND genus_name" to try to ensure that the paper is actually discussing that gene. Because EuropePMC indexes most recent biomedical papers, even if they are not open access, some of the links may be to papers that you cannot read or that our computers cannot read. We query each of these identifiers that appears in the open access part of EuropePMC, as well as every locus tag that appears in the 500 most-referenced genomes, so that a gene may appear in the PaperBLAST results even though none of the papers that mention it are open access. We also incorporate text-mined links from EuropePMC that link open access articles to UniProt or RefSeq identifiers. (This yields some additional links because EuropePMC uses different heuristics for their text mining than we do.)

For every article that mentions a locus tag, a RefSeq protein identifier, or a UniProt accession, we try to select one or two snippets of text that refer to the protein. If we cannot get access to the full text, we try to select a snippet from the abstract, but unfortunately, unique identifiers such as locus tags are rarely provided in abstracts.

PaperBLAST also incorporates manually-curated protein functions:

Except for GeneRIF and ENA, the curated entries include a short curated description of the protein's function. For entries from BioLiP, the protein's function may not be known beyond binding to the ligand. Many of these entries also link to articles in PubMed.

For more information see the PaperBLAST paper (mSystems 2017) or the code. You can download PaperBLAST's database here.

Changes to PaperBLAST since the paper was written:

Many of these changes are described in Interactive tools for functional annotation of bacterial genomes.

Secrets

PaperBLAST cannot provide snippets for many of the papers that are published in non-open-access journals. This limitation applies even if the paper is marked as "free" on the publisher's web site and is available in PubmedCentral or EuropePMC. If a journal that you publish in is marked as "secret," please consider publishing elsewhere.

Omissions from the PaperBLAST Database

Many important articles are missing from PaperBLAST, either because the article's full text is not in EuropePMC (as for many older articles), or because the paper does not mention a protein identifier such as a locus tag, or because of PaperBLAST's heuristics. If you notice an article that characterizes a protein's function but is missing from PaperBLAST, please notify the curators at UniProt or add an entry to GeneRIF. Entries in either of these databases will eventually be incorporated into PaperBLAST. Note that to add an entry to UniProt, you will need to find the UniProt identifier for the protein. If the protein is not already in UniProt, you can ask them to create an entry. To add an entry to GeneRIF, you will need an NCBI Gene identifier, but unfortunately many prokaryotic proteins in RefSeq do not have corresponding Gene identifers.

References

PaperBLAST: Text-mining papers for information about homologs.
M. N. Price and A. P. Arkin (2017). mSystems, 10.1128/mSystems.00039-17.

Europe PMC in 2017.
M. Levchenko et al (2017). Nucleic Acids Research, 10.1093/nar/gkx1005.

Gene indexing: characterization and analysis of NLM's GeneRIFs.
J. A. Mitchell et al (2003). AMIA Annu Symp Proc 2003:460-464.

UniProt: the universal protein knowledgebase.
The UniProt Consortium (2016). Nucleic Acids Research, 10.1093/nar/gkw1099.

BRENDA in 2017: new perspectives and new tools in BRENDA.
S. Placzek et al (2017). Nucleic Acids Research, 10.1093/nar/gkw952.

The EcoCyc database: reflecting new knowledge about Escherichia coli K-12.
I. M. Keeseler et al (2016). Nucleic Acids Research, 10.1093/nar/gkw1003.

The MetaCyc database of metabolic pathways and enzymes.
R. Caspi et al (2018). Nucleic Acids Research, 10.1093/nar/gkx935.

CharProtDB: a database of experimentally characterized protein annotations.
R. Madupu et al (2012). Nucleic Acids Research, 10.1093/nar/gkr1133.

The carbohydrate-active enzymes database (CAZy) in 2013.
V. Lombard et al (2014). Nucleic Acids Research, 10.1093/nar/gkt1178.

The Transporter Classification Database (TCDB): recent advances
M. H. Saier, Jr. et al (2016). Nucleic Acids Research, 10.1093/nar/gkv1103.

REBASE - a database for DNA restriction and modification: enzymes, genes and genomes.
R. J. Roberts et al (2015). Nucleic Acids Research, 10.1093/nar/gku1046.

Deep annotation of protein function across diverse bacteria from mutant phenotypes.
M. N. Price et al (2016). bioRxiv, 10.1101/072470.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory