PaperBLAST
PaperBLAST Hits for TCDB::P46333 Probable metabolite transport protein CsbC (Bacillus subtilis (strain 168)) (461 a.a., MKKDTRKYMI...)
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>TCDB::P46333 Probable metabolite transport protein CsbC (Bacillus subtilis (strain 168))
MKKDTRKYMIYFFGALGGLLYGYDTGVISGALLFINNDIPLTTLTEGLVVSMLLLGAIFG
SALSGTCSDRWGRRKVVFVLSIIFIIGALACAFSQTIGMLIASRVILGLAVGGSTALVPV
YLSEMAPTKIRGTLGTMNNLMIVTGILLAYIVNYLFTPFEAWRWMVGLAAVPAVLLLIGI
AFMPESPRWLVKRGSEEEARRIMNITHDPKDIEMELAEMKQGEAEKKETTLGVLKAKWIR
PMLLIGVGLAIFQQAVGINTVIYYAPTIFTKAGLGTSASALGTMGIGILNVIMCITAMIL
IDRVGRKKLLIWGSVGITLSLAALSGVLLTLGLSASTAWMTVVFLGVYIVFYQATWGPVV
WVLMPELFPSKARGAATGFTTLVLSAANLIVSLVFPLMLSAMGIAWVFMVFSVICLLSFF
FAFYMVPETKGKSLEEIEASLKKRFKKKKSTQNQVLNERTL
Running BLASTp...
Found 252 similar proteins in the literature:
TC 2.A.1.1.106 / P46333 Probable metabolite transport protein CsbC from Bacillus subtilis (strain 168) (see 3 papers)
100% identity, 100% coverage
- substrates: Metabolites
- Major facilitator superfamily
Pao, Microbiology and molecular biology reviews : MMBR 1998 - “...P09830 P45598 P37021 P21906 P15729 U29579 X86780 P09098 P31578 P54723 U66480 P46333 P42417 P37514 SP SP SP SP SP GB GB SP SP SP GB SP SP SP Ar Sulfolobus...”
BSU35830 putative carbohydrate transporter from Bacillus subtilis subsp. subtilis str. 168
50% identity, 98% coverage
- Secondary structural entropy in RNA switch (Riboswitch) identification
Manzourolajdad, BMC bioinformatics 2015 - “...-55.60 - 0.4600 123.0559998 - 0.3600 899 yxeF BSU39570 0.8090547919 200 nt 3688648 3688847 reverse BSU35830 ywtG -3786 -49.93 - 0.3300 120.9260025 - 0.3550 199 yvyI BSU35790 0.8084035516 200 nt 1668788 1668987 reverse BSU15960 ylqB -2279 -51.60 - 0.4050 122.7809982 - 0.4150 13099 rpmB BSU15820 0.8080439568...”
SE0247 bicyclomycin resistance protein TcaB from Staphylococcus epidermidis ATCC 12228
54% identity, 95% coverage
GLCP_STAES / A0A0H2VG78 Glucose transporter GlcP; Glucose/H(+) symporter from Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200) (see paper)
SERP_RS11465 sugar porter family MFS transporter from Staphylococcus epidermidis RP62A
54% identity, 95% coverage
DV527_RS12535 sugar porter family MFS transporter from Staphylococcus saprophyticus
55% identity, 96% coverage
DV527_RS02780 sugar porter family MFS transporter from Staphylococcus saprophyticus
53% identity, 98% coverage
XYLT_LEVBR / O52733 D-xylose transporter; D-xylose-proton symporter from Levilactobacillus brevis (Lactobacillus brevis) (see paper)
TC 2.A.1.1.41 / O52733 The D-xylose:H+ symporter, XylT (Km=220 μM; inhibited competitively by 6-deoxyglucose (Ki=220 μM), but not by other sugars tested) from Lactobacillus brevis
48% identity, 96% coverage
- function: Uptake of D-xylose across the boundary membrane with the concomitant transport of protons into the cell (symport system). Transport is driven by the proton motive force generated by either malolactic fermentation or by the metabolism of D-glucose.
- substrates: Xylose
- Proton-coupled sugar transport in the prototypical major facilitator superfamily protein XylE.
Wisedchaisri, Nature communications 2014 - “...accession number in parentheses: Escherichia coli XylE (P0AGF4); Lactobacillus brevis D -xylose/H + symporter XylT (O52733); Escherichia coli galactose permease GalP (P0AEP1); Escherichia coli arabinose permease AraE (P0AE24); Bacillus subtilis myo-inositol/H + transporter IolT (O34718); Arabidopsis thaliana inositol/H + symporter INT1 (Q8VZR6); Arabidopsis thaliana hexose/H +...”
Cbei_0109 sugar transporter from Clostridium beijerincki NCIMB 8052
45% identity, 97% coverage
- CRISPR-Cas technology a new era in genomic engineering
Parsaeimehr, Biotechnology reports (Amsterdam, Netherlands) 2022 - “...the solvent production in C. beijerinckii the genes ctfAB, cbei_3833/3834, and xylR, cbei_2385, and xylT, cbei_0109 responsible for the organic acids re-assimilation and pentose utilization, were edited using the introduced CRISPR-Cas system. As a result, the genome engineered Clostridia was able to decompose 83.2g/L of deshelled...”
- Enhanced solvent production by metabolic engineering of a twin-clostridial consortium
Wen, Metabolic engineering 2017 (PubMed)- “...and pentose utilization (xylR, cbei_2385 and xylT, cbei_0109) were engineered in C. beijerinckii to enhance solvent production. The engineered twin-clostridia...”
- “...by inactivating xylR ( cbei_2385 )and overexpressing xylT ( cbei_0109 ) to promote pentose utilization. Fig. 1 Fig. 2 A CRISPRi system was adapted to repress...”
- Reconstruction of xylose utilization pathway and regulons in Firmicutes
Gu, BMC genomics 2010 - “...related protein Clostridium , C. saccharolyticus XylB CAC2612 Xylulokinase Xylulokinase (with CAC1344) Bacilli, Clostridia XylT Cbei_0109 Xylose H + -symporter Sugar transporter Clostridium , Lactobacillales XylR CAC3673 Xylose regulator XylR regulator (with CAC0933 ) Bacilli, Clostridia XynT CAC3451 Xyloside Na + (H + ) - symporter...”
X276_26120 sugar porter family MFS transporter from Clostridium beijerinckii NRRL B-598
45% identity, 97% coverage
LLKF_1623 D-xylose-proton symporter from Lactococcus lactis subsp. lactis KF147
47% identity, 97% coverage
HAH_5129 sugar porter family MFS transporter from Haloarcula hispanica ATCC 33960
43% identity, 97% coverage
- A conserved transcription factor controls gluconeogenesis via distinct targets in hypersaline-adapted archaea with diverse metabolic capabilities
Hackley, PLoS genetics 2024 - “...4 * 92.46 yes promoter HAH_4332 gdh glucose dehydrogenase 5 * 85.71 5.96 yes promoter HAH_5129 4.72 sugar porter family MFS transporter 6 * 49.84 4.46 yes promoter promoter HAH_1365 HAH_1366 porA flavodoxin reductase family I pyruvate:ferredoxin oxidoreductase 7 * 47.56 yes promoter HAH_0887 cysK -1.36...”
- “...5 , hypergeometric test). Notably, the second largest peak is located in the promoter of HAH_5129, a sugar major facilitator superfamily (MFS) transporter (PF00083, e-value < 3.0 10 123 ), highlighting this gene as a candidate for the primary glucose transporter in Har. hispanica . Computational...”
E4NW64 MFS transporter, sugar porter family from Halogeometricum borinquense (strain ATCC 700274 / DSM 11551 / JCM 10706 / KCTC 4070 / PR3)
45% identity, 92% coverage
LEUM_0128 D-xylose proton-symporter from Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293
41% identity, 92% coverage
- Glycosyltransferases Expression Changes in Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 Grown on Different Carbon Sources
Vallejo-García, Foods (Basel, Switzerland) 2023 - “...one up-regulated membrane transporter when using fructose (LEUM_0853) and a different one up-regulated in xylose (LEUM_0128). These findings indicate that fructose and xylose enter the cell through membrane symporters from the MFS. As expected, genes related to xylose transport and metabolism are highly up-regulated when Ln....”
- “...xylose as CS ( Figure 3 ). These genes correspond to the xylose symporter xylT (LEUM_0128, LOG 2 FC = 4.8), the xylose-isomerase xylA (LEUM_0130, LOG 2 FC = 5.9), the xylulokinase xylB (LEUM_0131, LOG 2 FC = 4.3). It is most probable than xylA and...”
DB43_AL00090 sugar porter family MFS transporter from Parachlamydia acanthamoebae
43% identity, 94% coverage
- A Genomic and Transcriptomic Overview of MATE, ABC, and MFS Transporters in Citrus sinensis Interaction with Xanthomonas citri subsp. citri
Julião, Plants (Basel, Switzerland) 2020 - “...MAFFT version 7.4 [ 81 ], with standard parameters. The outgroup sequences AK812_OLP99436, AK812_OLP95568, and DB43_AL00090, were retrieved from HMMER Ensembl Genomes. The best-of-fit model LG+G+F [ 82 ] was estimated for both ABC and MFS datasets, while WAG+G+F [ 83 ] for the MATE dataset...”
- “...Citrus spp. identified in the citrus reference transcriptome. Numbers above the branches represent bootstrap values. DB43_AL00090 was used as outgroup ( Parachlamydia acanthamoebae , gene ywtG, putative metabolite transport protein YwtG), Figure S3: Maximum likelihood tree of MFS amino acid sequences expressed by Citrus spp. identified...”
LEGAS_1062 sugar porter family MFS transporter from Leuconostoc gasicomitatum LMG 18811
41% identity, 92% coverage
- Complete genome sequence of Leuconostoc gelidum subsp. gasicomitatum KG16-1, isolated from vacuum-packaged vegetable sausages
Andreevskaya, Standards in genomic sciences 2016 - “...strains. In addition, KG16-1 was lacking the ortholog of another xylose transporter xylT (e.g. gene LEGAS_1062 in LMG 18811 T ), which was present in other strains. D- Ala --D- Ala ligase gene ddl (LEKG_0342) contained Phe 261 in its active site, which indicates a resistance...”
- “...biofilm formation genes icaB and icaA (LEGAS_1065, LEGAS_1067); collagen-binding protein cna (LEGAS_1063); xylose-proton symporter xylT (LEGAS_1062); mucus-binding protein (LEGAS_0414); accessory Sec system genes secY2, asp1, asp2, asp3, secA2, nss, gtfA, gtfB, asp4 (LEKG_0540-0548); fused glutamate racemase/NTP pyrophosphatase (LEKG_0672) a Phylogenetic analysis (Figure S1 of Additional file...”
XNR_0140 sugar porter family MFS transporter from Streptomyces albidoflavus
41% identity, 95% coverage
- Insights into naturally minimised Streptomyces albus J1074 genome
Zaburannyi, BMC genomics 2014 - “...36 ]. Genes are present for efflux proteins for daunorubicin (XNR_2457-58, XNR_4042-43), camphor (XNR_2486-87), bicyclomycin (XNR_0140), tetracycline (XNR_3352) and one putative macrolide glycosyltransferase (XNR_4394). S. albus contains two genes for tryptophanyl-tRNA synthetase: XNR_3910 and XNR_3513, of which the latter is an ortholog of indolmycin-resistant Trp-synthetase from...”
LEUM_0853 D-xylose proton-symporter from Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293
42% identity, 95% coverage
F9ULF8 Myo-inositol (And similar sugars) transporter,major facilitator superfamily (MFS) from Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
40% identity, 94% coverage
TC 2.A.1.1.116 / C4B4V9 Arabinose/xylose transporter, AraE from Corynebacterium glutamicum
41% identity, 92% coverage
- substrates: Arabinose, Xylose
Cbei_4545 sugar transporter from Clostridium beijerincki NCIMB 8052
39% identity, 96% coverage
Lreu_0479 sugar porter family MFS transporter from Limosilactobacillus reuteri subsp. reuteri
Lreu_0479 sugar transporter from Lactobacillus reuteri DSM 20016
39% identity, 96% coverage
CAC1345 D-xylose-proton symporter from Clostridium acetobutylicum ATCC 824
CA_C1345 sugar porter family MFS transporter from Clostridium acetobutylicum ATCC 824
39% identity, 98% coverage
- Valorisation of xylose to renewable fuels and chemicals, an essential step in augmenting the commercial viability of lignocellulosic biorefineries
Narisetty, Sustainable energy & fuels 2021 - “...Along with XI, XK ( XylB , CAC2612), a xylose proton symporter ( XylT , CAC1345), and a transcriptional regulator ( XylR , CAC3673) were also sequenced and characterized. The C. acetobutylicum strains are well known to utilize a broad range of monosaccharides, disaccharides, starches, and...”
- Biochemical routes for uptake and conversion of xylose by microorganisms
Zhao, Biotechnology for biofuels 2020 - “...are not detected in the chromosome of C. acetobutylicum , and only several genes (CAC1339, CAC1345, CAC1530, CAC3422 and CAC3451) encoding sugar-proton symporters are identified [ 20 , 21 ]. These above symporter genes are distributed in the different parts of the chromosome, and located relatively...”
- Sugar uptake by the solventogenic clostridia
Mitchell, World journal of microbiology & biotechnology 2016 - “...C. acetobutylicum and C. beijerinckii. Three symporters in C. acetobutylicum , encoded by cac1339 , cac1345 and cac3451 , have been shown to be induced under conditions in which xylose is being used as a substrate (Grimmler et al. 2010 ; Servinsky et al. 2010 )....”
- “...al. 2012 ). It is therefore possible that the putative transporters encoded by cac1339 and cac1345 ( xylT ) are involved in uptake of both pentose sugars, but this has yet to be examined. Furthermore, expression of genes cac1529 and cac1530 encoding, respectively, a putative arabinosidase...”
- Bacterial xylanases: biology to biotechnology
Chakdar, 3 Biotech 2016 - “..., the xylose utilization pathway also includes a xylulokinase (XylB, CAC2612), a xylose proton-symporter (XylT, CAC1345), and a transcriptional regulator (XylR, CAC3673). xyn D and xyn T along with xyl genes are under transcriptional control of XylR. Bacteria are endowed with varying xylanolytic activity with distinct...”
- Ribulokinase and transcriptional regulation of arabinose metabolism in Clostridium acetobutylicum
Zhang, Journal of bacteriology 2012 - “...and CAC1346), araD (CAC1341), and araE (CAC1339 and CAC1345) genes in the araR-inactivated mutant were elevated more than 17-fold compared to that of the...”
- “...for two putative arabinose protonsymporters (CAC1339 and CAC1345), which are considered to be responsible for arabinose uptake. Our previous genetic mutagenesis...”
- Pleiotropic functions of catabolite control protein CcpA in Butanol-producing Clostridium acetobutylicum
Ren, BMC genomics 2012 - “...product Change fold (824ccpA/824WT) Middle exponential phase (M) Stationary phase (S) Microarray qRT-PCR* Microarray qRT-PCR* CAC1345 xylT l -arabinose-proton symporter 71.6 92.522.55 147.39 326.54176.86 CAC2612 xylB Xylulose kinase 26.9 20.44.00 17.9 21.210.02 CAC1348 tkt1 Transketolase 5.6 4.420.23 7.9 6.40.21 CAC1941 abrB1941 Stationary/sporulation gene regulator 5.1 89.177.31...”
- “...most of the genes necessary for l -arabinose uptake and metabolism, including araE1/araE2 (CAC1339 and CAC1345, encoding l -arabinose-proton symporter), araA1/araA2 (CAC1342 and CAC1346, encoding l -arabinose isomerase), araK (CAC1344, encoding ribulokinase) [ 44 ], araD (CAC1341, encoding l -ribulose-5-phosphate 4-epimerase), epi (CAC1349, encoding aldose 1-epimerase)...”
- Confirmation and elimination of xylose metabolism bottlenecks in glucose phosphoenolpyruvate-dependent phosphotransferase system-deficient Clostridium acetobutylicum for simultaneous utilization of glucose, xylose, and arabinose
Xiao, Applied and environmental microbiology 2011 - “...overcome by co-overexpression of the D-xylose proton-symporter (cac1345), D-xylose isomerase (cac2610), and xylulokinase (cac2612). As a result, an engineered...”
- “...promoter Derived from pIMP1-Pthl, with xylT gene (cac1345) expressing cassette added Derived from pIMP1-Pthl, with xylA gene (cac2610) expressing cassette added...”
- Reconstruction of xylose utilization pathway and regulons in Firmicutes
Gu, BMC genomics 2010 - “...acetobutylicum the xylose utilization pathway also includes a xylulokinase (XylB, CAC2612), a xylose proton-symporter (XylT, CAC1345), and a transcriptional regulator (XylR, CAC3673). The predicted functions of these genes in C. acetobutylicum were experimentally confirmed through a combination of genetic and biochemical techniques. We conclusively showed that...”
- “...of Bacilli/Clostridia have been annotated as xylose proton-symporter in the public databases ( e.g . CAC1345 of C. acetobutylicum ). In this study XylT was tentatively identified in more species such as C. beijerinckii . This functional assignment is supported by the conserved co-localization on the...”
- Alleviation of Carbon Catabolite Repression through araR and xylR Inactivation in Clostridium acetobutylicum DSM 792
Delarouzée, Applied and environmental microbiology 2023 (secret) - Harnessing lignocellulosic biomass for butanol production through clostridia for sustainable waste management: recent advances and perspectives
Palaniswamy, Frontiers in bioengineering and biotechnology 2023 - “...inactivating araR ( Clocel_1253 ) and xylR ( Clocel_0594 ) along with overexpressing xylT ( CA_C1345 ). The resulting strain could produce 4.96g/L of butanol from alkali-extracted corn cobs ( Wen et al., 2020 ). The bacterium C. tyrobutyricum ATCC 25755 was engineered by overexpressing the...”
- Production of butanol from lignocellulosic biomass: recent advances, challenges, and prospects
Guo, RSC advances 2022 - “...carbon flux from butyrate and acetate toward butyryl-CoA. Xylose metabolism was engineered by overexpressing xylT (CA_C1345) and inactivating xylR (Clocel_0594) and araR (Clocel_1253), and final production of butanol was increased to 4.96 g L 1 directly from alkali-extracted corncobs. 161 4.3 A strategy for engineering physiological...”
- Metabolic Engineering of Clostridium cellulovorans to Improve Butanol Production by Consolidated Bioprocessing
Wen, ACS synthetic biology 2020 (PubMed)- “...engineering was implemented by inactivating xylR (Clocel_0594) and araR (Clocel_1253), as well as overexpressing xylT (CA_C1345), which is expected to supply additional carbon and reducing power for CoA and butanol synthesis pathways. The final engineered strain produced 4.96 g/L of n-butanol from alkali extracted corn cobs...”
P54723 Putative metabolite transport protein YfiG from Bacillus subtilis (strain 168)
37% identity, 92% coverage
- Major facilitator superfamily
Pao, Microbiology and molecular biology reviews : MMBR 1998 - “...439 451 P09830 P45598 P37021 P21906 P15729 U29579 X86780 P09098 P31578 P54723 U66480 P46333 P42417 P37514 SP SP SP SP SP GB GB SP SP SP GB SP SP SP Ar...”
IOLT_BACSU / O34718 Major myo-inositol transporter IolT from Bacillus subtilis (strain 168) (see paper)
TC 2.A.1.1.26 / O34718 Major myoinositol:H+ symporter, IolT from Bacillus subtilis (see 3 papers)
37% identity, 93% coverage
- function: Major myo-inositol uptake transporter.
- substrates: myo-inositol
- Proton-coupled sugar transport in the prototypical major facilitator superfamily protein XylE
Wisedchaisri, Nature communications 2014 - “...permease GalP (P0AEP1); Escherichia coli arabinose permease AraE (P0AE24); Bacillus subtilis myo-inositol/H + transporter IolT (O34718); Arabidopsis thaliana inositol/H + symporter INT1 (Q8VZR6); Arabidopsis thaliana hexose/H + symporter STP1 (P23586); Parachlorella kessleri hexose/H + symporter HUP1 (P15686); Homo sapiens facilitated glucose transporter GLUT12 (Q8TD20); Homo sapiens...”
SXYL_00126 sugar porter family MFS transporter from Staphylococcus xylosus
40% identity, 94% coverage
HGB56_08960 sugar porter family MFS transporter from Lactiplantibacillus plantarum
41% identity, 92% coverage
- The Carbohydrate Metabolism of Lactiplantibacillus plantarum
Cui, International journal of molecular sciences 2021 - “...4-epimerase ( araD , HGB56_08950), L-ribulokinase ( araB , HGB56_08955), arabinose transporter ( araP , HGB56_08960), transcription regulator ( araR , HGB56_08965, GntR family), and hypothetical protein (HGB56_08935). The strains WCFS1, LP-F1, JDM1, 5-2, SN35N, K25, ST-III, CAUH2, J26, and LZ95 possess the gene cluster (...”
TC 2.A.1.1.42 / Q8G3X1 The D-glucose:H+ symporter, GlcP (glucose uptake is inhibited by 2-deoxyglucose, mannose and galactose) from Bifidobacterium longum (see paper)
BL1631 D-Glucose-proton symporter from Bifidobacterium longum NCC2705
41% identity, 84% coverage
- substrates: D-glucose, H+
- The Pleiotropic Effects of Carbohydrate-Mediated Growth Rate Modifications in Bifidobacterium longum NCC 2705
Duboux, Microorganisms 2023 - “...(bifid-shunt). It revealed that growth on glucose induced the expression of glucose import systems ( Bl1631 (MFS) and BL1633 (part of PTS)), enzymes involved in glucose-6-phosphate conversion ( BL1631 ; 6PGL ), pyruvate and acetate formation ( BL0707 ( pgk ) and BL1124 ( aldH )),...”
- “...malE )), channeling of galactose and glucose into the bifid-shunt ( BL1630 ( pgm ), BL1631 ( pgm ), BL0279 ( pgi )). Notably, two of the MalR1 target loci were induced when the strain was grown on glucose, i.e., genes involved in metabolization of amylose...”
- Preferential sugar utilization by bifidobacterial species
Murakami, Microbiome research reports 2023 - “...we investigated the homolog distribution of the glcP , ptsG , and licT gene cluster (BL1631, BL1632, and BL1633 in B. longum NCC2705), which are reportedly involved in the preferential utilization of lactose in NCC2705 [ 20 ] . Of the 40 isolates, 12 strains had...”
- Carbohydrate-controlled serine protease inhibitor (serpin) production in Bifidobacterium longum subsp. longum
Duboux, Scientific reports 2021 - “...glucose in the environment. In B. longum NCC 2705, the glucose/mannose transporter protein (encoded by BL1631; glcP) is involved in galactose import 8 . This protein was demonstrated to have the highest specificity for glucose followed by mannose and galactose 23 , which could explain why...”
- “...to have a higher affinity to the Major Facilitator Superfamily (MFS) transport protein glcP protein (BL1631). As well, presence of glucose in the cell has been previously shown to inhibit the production of the ATP-binding cassette transporters (ABC) encoded by the genes located in the operon...”
- Lactose-over-glucose preference in Bifidobacterium longum NCC2705: glcP, encoding a glucose transporter, is subject to lactose repression
Parche, Journal of bacteriology 2006 - “...Gene Accession number Primer pair BL1631 ( glcP) AAN25419 BL1631-F1, GCAACGCCTTCAAAGTGCTT BL1631-R1, TGCACCTGGGTCTGATCCA AAN25418 BL1630-F1, TCAAGCGTGTGCCCTACGA...”
- “...repressed by lactose and probably induced by glucose. BL1631 expression is mediated by lactose. Comparative analysis of gene expression using genome-wide DNA...”
BBMN68_1664 sugar porter family MFS transporter from Bifidobacterium longum subsp. longum BBMN68
41% identity, 84% coverage
- Mechanism analysis of acid tolerance response of bifidobacterium longum subsp. longum BBMN 68 by gene expression profile using RNA-sequencing
Jin, PloS one 2012 - “...major facilitator superfamily proteins (MFS), which allow glucose to be symported with H + . BBMN68_1664 encoding the D-glucose-H + symporter (GlcP), one member of the putative permeases of the MFS in BBMN68, was found to have been upregulated by 2.17 fold ( Table S2 )....”
- Complete genome sequence of Bifidobacterium longum subsp. longum BBMN68, a new strain from a healthy chinese centenarian
Hao, Journal of bacteriology 2011 - “...(BBMN68_1004, BBMN68_1297) and sugar efflux (BBMN68_78, BBMN68_188, BBMN68_1664, BBMN68_1684) were found in the genome. A gene encoding a serine protease...”
CTK_C04350 sugar porter family MFS transporter from Clostridium tyrobutyricum
38% identity, 95% coverage
F7308_1395 sugar porter family MFS transporter from Francisella salina
37% identity, 93% coverage
- Genetic diversity within the genus Francisella as revealed by comparative analyses of the genomes of two North American isolates from environmental sources
Siddaramappa, BMC genomics 2012 - “...213 aa, 37%, 4e-34 F7308_1394 (471 aa) Glucuronate isomerase (UxaC) Sde_1272, 471 aa, 51%, 3e-140 F7308_1395 (463 aa) D-xylose-proton symporter (XylT) CBUD_1731, 463 aa, 43%, 3e-91 F7308_1396 (325 aa) Inositol oxygenase 56727 Miox, 285 aa, 37%, 3e-47 Lactose metabolism 4 Fphi_0309 (655 aa) Beta-galactosidase BMD_1886, 651...”
PPYC1_19055 sugar porter family MFS transporter from Paenibacillus polymyxa
39% identity, 91% coverage
- Transcriptome Profiles Reveal the Growth-Promoting Mechanisms of Paenibacillus polymyxa YC0136 on Tobacco (Nicotiana tabacum L.)
Liu, Frontiers in microbiology 2020 - “...interaction. Four genes involved in ABC transport were down-regulated by 1.542.60 times. Two genes ( PPYC1_19055 and PPYC1_22815 ) involved in MFS transfer were down-regulated by 1.67 times and 4.69 times, respectively. These benefit the growth of strain YC0136 by absorbing nutrients. TABLE 5 Effects of...”
- “...transporter permease PPYC1_02025 1.54 Amino acid ABC transporter substrate-binding protein PPYC1_01710 1.58 ABC transporter permease PPYC1_19055 1.67 araE MFS transporter PPYC1_00995 1.72 PTS sugar transporter subunit IIB PPYC1_13110 2.04 znuB Metal ABC transporter permease PPYC1_13115 2.6 znuC Metal ABC transporter ATP-binding protein PPYC1_00515 3.13 smr QacE...”
TC 2.A.1.1.53 / Q8NTX0 Myo-Inositol uptake porter, IolT1 (Km=0.2mM) from Corynebacterium glutamicum (Brevibacterium flavum) (see paper)
NCgl0178 sugar porter family MFS transporter from Corynebacterium glutamicum ATCC 13032
cg0223 metabolite transport protein from Corynebacterium glutamicum ATCC 13032
36% identity, 90% coverage
- substrates: glucose, myo-inositol
tcdb comment: Can also transport D-glucose (Ikeda et al. 2011) - A Futile Metabolic Cycle of Fatty Acyl-CoA Hydrolysis and Resynthesis in Corynebacterium glutamicum and Its Disruption Leading to Fatty Acid Production
Ikeda, Applied and environmental microbiology 2021 - “...and WTfasRtesA, respectively, were used as host strains to replace the chromosomal iolT1 gene (Cgl0181, NCgl0178), which is expressed under the control of its native myo -inositol-inducible promoter ( 43 ), with the tesA gene. For this gene replacement, plasmid pCPiolT1-tesA was constructed as follows. The...”
- Complex regulation of the phosphoenolpyruvate carboxykinase gene pck and characterization of its GntR-type regulator IolR as a repressor of myo-inositol utilization genes in Corynebacterium glutamicum
Klaffl, Journal of bacteriology 2013 - “...NCgl0159 NCgl0160 NCgl0161 NCgl0162 NCgl0163 NCgl0164 NCgl0167 NCgl0178 NCgl0900 NCgl1353 NCgl1650 iolC cg2560 cg2732 cg3096 cg3107 cg3169 cg3195 cg3216...”
- Characterization of myo-inositol utilization by Corynebacterium glutamicum: the stimulon, identification of transporters, and influence on L-lysine formation
Krings, Journal of bacteriology 2006 - “...NCgl0161 NCgl0162 NCgl0163 NCgl0164 NCgl0167 NCgl0168 NCgl0178 NCgl0697 NCgl0916 NCgl0933 NCgl1368 NCgl1917 NCgl2477 NCgl2865 NCgl2894 NCgl2904 NCgl2951...”
- HrrSA orchestrates a systemic response to heme and determines prioritization of terminal cytochrome oxidase expression
Keppel, Nucleic acids research 2020 - “...EIIGlc of PTS 70 1.6 1.1 0.1 cg2091 ppgG Polyphosphate glucokinase 199 266 0.2 0.8 cg0223 iolT1 Myo-Inositol transporter 1, alternative glucose uptake system 73 2.0 1.0 0.7 Signal transduction cg0986 amtR Master regulator of nitrogen control, repressor, TetR-family 366 1.8 0.3 0.1 Cg2461 benR Transcriptional...”
- Identifying the Growth Modulon of Corynebacterium glutamicum
Haas, Frontiers in microbiology 2019 - “...and ptsI (cg2117), encoding the glucose uptake system as well as the gene encoding iolT1 (cg0223) which has been shown to also enable glucose uptake. Genes ppgk (cg2091) and cg2932 , which encode glucokinases were also in cluster 1. Interestingly, gpmA (cg0482) and pgm (cg2800) were...”
- Impact of CO2/HCO3- Availability on Anaplerotic Flux in Pyruvate Dehydrogenase Complex-Deficient Corynebacterium glutamicum Strains
Krüger, Journal of bacteriology 2019 (secret) - Complex regulation of the phosphoenolpyruvate carboxykinase gene pck and characterization of its GntR-type regulator IolR as a repressor of myo-inositol utilization genes in Corynebacterium glutamicum
Klaffl, Journal of bacteriology 2013 - “...cg0202 cg0203 cg0204 cg0205 cg0206 cg0207 cg0210 cg0223 cg1069 cg1595 cg1935 NCgl0155 NCgl0156 NCgl0157 NCgl0158 NCgl0159 NCgl0160 NCgl0161 NCgl0162 NCgl0163...”
- “...likely cotranscribed as an operon. The iolT1 gene (cg0223) encoding myo-inositol transporter 1 is located further downstream in a divergent orientation. The...”
- Phosphotransferase system-independent glucose utilization in corynebacterium glutamicum by inositol permeases and glucokinases
Lindner, Applied and environmental microbiology 2011 - “...(cg2121) and ppgK (cg2091) In-frame deletions of iolT1 (cg0223) and iolT2 (cg3387) In-frame deletions of iolT1 (cg0223), iolT2 (cg3387), and hpr (cg2121)...”
- “...Derived from pEKEx3, for regulated expression of iolT1 (cg0223) of C. glutamicum Derived from pEKEx3, for regulated expression of iolT2 (cg3387) of C....”
AFE_2312, AFE_RS10630 sugar porter family MFS transporter from Acidithiobacillus ferrooxidans ATCC 23270
38% identity, 95% coverage
- Characterize the Growth and Metabolism of <i>Acidithiobacillus ferrooxidans</i> under Electroautotrophic and Chemoautotrophic Conditions
Wang, Microorganisms 2024 - “...protein 1.66 novel0005 - MULTISPECIES: ferredoxin family protein 1.57 AFE_RS09710 AFE_RS09710 ABC-2 transporter permease 1.49 AFE_RS10630 AFE_RS10630 sugar porter family MFS transporter 1.28 AFE_RS13730 AFE_RS13730 peptide ABC transporter substrate-binding protein 1.19...”
- Enhancement Mechanism of Stibnite Dissolution Mediated by Acidithiobacillus ferrooxidans under Extremely Acidic Condition
Wang, International journal of molecular sciences 2022 - “...AFE_1652 (encoding oxidoreductase alpha subunit), AFE_1651 (encoding 3-hydroxyisobutyrate dehydrogenase family protein), AFE_1589 (encoding DNA-damage-inducible protein), AFE_2312 (encoding Major facilitator superfamily (MFS) transporter), AFE_1636 (encoding hypothetical protein). These up-regulated genes are mainly annotated as the function of metabolic process, cellular process, binding, catalytic activity, transporter activity, molecular...”
- “...transfer in the biotransformation of Sb (III) in the presence of trace iron. In addition, AFE_2312 is very similar to xylose and galactose proton symporters, which is proposed to be related to the MFS transporter superfamily contributing to the carbohydrate transporter of the outer membrane [...”
ETAE_2966 sugar transporter from Edwardsiella tarda EIB202
37% identity, 91% coverage
lpp0488 hypothetical protein from Legionella pneumophila str. Paris
38% identity, 95% coverage
lpg0421 D-xylose (galactose, arabinose)-proton symporter from Legionella pneumophila subsp. pneumophila str. Philadelphia 1
38% identity, 95% coverage
- Mammalian Solute Carrier (SLC)-like transporters of Legionella pneumophila
Best, Scientific reports 2018 - “...sequence from the human SLC2 and SLC5 family, we identified two putative SLC-like glucose transporters, lpg0421 (33%/50%) and lpg1653 (30%/48%) (Table 1 ). Structural modeling of these proteins was done using the Iterative Threading Assembly Refinement (I-TASSER) server, which is a bioinformatics algorithm for predicting three-dimensional...”
- “...SLCs. Amino acid identity (BLAST) Amino acid similarity (BLAST) Putative substrates Representative SLC, TM-score LstA (Lpg0421) 33% 50% Glucose and other monosaccharides SLC2a1 (0.903) LstB (Lpg1653) 30% 48% Glucose and other monosaccharides SLC2a1 (0.922) LstC (Lpg0026) 37% 56% Cationic amino acids (arginine, lysine, ornithine) SLC7a1 (0.953)...”
- Metabolism of the vacuolar pathogen Legionella and implications for virulence
Manske, Frontiers in cellular and infection microbiology 2014 - “...uptake of sugars have not been studied in molecular detail at present. The gene ywtG (lpg0421) is conserved among L. pneumophila and L. longbeachae , and annotated as a putative D-xylose (galactose, arabinose)-proton symporter (Cazalet et al., 2004 , 2010 ). However, arabinose appears to be...”
APA386B_1333 sugar porter family MFS transporter from Acetobacter pasteurianus 386B
36% identity, 89% coverage
CH1034_220103 sugar porter family MFS transporter from Klebsiella pneumoniae
36% identity, 94% coverage
CAC1339 Possible sugar-proton symporter from Clostridium acetobutylicum ATCC 824
CA_C1339 sugar porter family MFS transporter from Clostridium acetobutylicum ATCC 824
36% identity, 96% coverage
- Biochemical routes for uptake and conversion of xylose by microorganisms
Zhao, Biotechnology for biofuels 2020 - “...transporter are not detected in the chromosome of C. acetobutylicum , and only several genes (CAC1339, CAC1345, CAC1530, CAC3422 and CAC3451) encoding sugar-proton symporters are identified [ 20 , 21 ]. These above symporter genes are distributed in the different parts of the chromosome, and located...”
- Development of an inducible transposon system for efficient random mutagenesis in Clostridium acetobutylicum
Zhang, FEMS microbiology letters 2016 - “...Minton ( 2015 ) pMTL82254-Pcac1339 Clostridium modular plasmid with catP reporter expressed by promoter of cac1339, pBP1 (Gram + origin), ColE1+ tra (Gram origin), Em r This study pMTL82254-Pcac1344 Clostridium modular plasmid with catP reporter expressed by promoter of cac1344, pBP1 (Gram + origin), ColE1+ tra...”
- “...pBP1 with pCB102 replicon This study pMTL-YG3 Derived from pMTL-YG0 by introducing the promoter of cac1339 to express the transposase Himar1 C9 This study a hsdR , host-specific restriction deficient; mcr , methylcytosine-specific restriction abolished; recA1 , homologous recombination abolished; endA1 , endonucleases abolished; Spe r...”
- Sugar uptake by the solventogenic clostridia
Mitchell, World journal of microbiology & biotechnology 2016 - “...in both C. acetobutylicum and C. beijerinckii. Three symporters in C. acetobutylicum , encoded by cac1339 , cac1345 and cac3451 , have been shown to be induced under conditions in which xylose is being used as a substrate (Grimmler et al. 2010 ; Servinsky et al....”
- “...al. 2015 ). In the case of arabinose, a gene cluster in C. acetobutylicum ( cac1339 cac1349 ) has been shown to be under control of a putative AraR regulator, and some of the genes in this region including cac1339 were found to be induced by...”
- Ribulokinase and transcriptional regulation of arabinose metabolism in Clostridium acetobutylicum
Zhang, Journal of bacteriology 2012 - “...araA (CAC1342 and CAC1346), araD (CAC1341), and araE (CAC1339 and CAC1345) genes in the araR-inactivated mutant were elevated more than 17-fold compared to that...”
- “...poorly explored family (Y. Zhang, personal communication). The CAC1339 to -1349 gene cluster in the C. acetobutylicum genome includes genes for two AraA...”
- Pleiotropic functions of catabolite control protein CcpA in Butanol-producing Clostridium acetobutylicum
Ren, BMC genomics 2012 - “...cluster contains most of the genes necessary for l -arabinose uptake and metabolism, including araE1/araE2 (CAC1339 and CAC1345, encoding l -arabinose-proton symporter), araA1/araA2 (CAC1342 and CAC1346, encoding l -arabinose isomerase), araK (CAC1344, encoding ribulokinase) [ 44 ], araD (CAC1341, encoding l -ribulose-5-phosphate 4-epimerase), epi (CAC1349, encoding...”
- Confirmation and elimination of xylose metabolism bottlenecks in glucose phosphoenolpyruvate-dependent phosphotransferase system-deficient Clostridium acetobutylicum for simultaneous utilization of glucose, xylose, and arabinose
Xiao, Applied and environmental microbiology 2011 - “...isomerase; xylB (cac2612), xylulokinase; araE (cac1339), L-arabinose transporter; araA (cac1342, cac1346), L-arabinose isomerase; araB (cac1344?),...”
- “...Only putative D-xylose and undefined sugar symporters (cac1339, cac3422, and cac1345) were observed. In general, symporters exhibit much lower affinity for...”
- Alleviation of Carbon Catabolite Repression through araR and xylR Inactivation in Clostridium acetobutylicum DSM 792
Delarouzée, Applied and environmental microbiology 2023 (secret) - Arabinose-Induced Catabolite Repression as a Mechanism for Pentose Hierarchy Control in Clostridium acetobutylicum ATCC 824
Servinsky, mSystems 2018 - “...( 14 , 19 ). Rodionov et al. identified AraR (CA_C1340) binding sites upstream of CA_C1339, CA_C1340, the predicted CA_C1341-CA_C1342 operon, CA_C1343, the predicted CA_C1344-CA_C1349 operon, and the predicted CA_C1529-CA_C1530 operon ( 28 ). The binding of AraR to these sites was confirmed by EMSA, and...”
- “...on arabinose than in xylose or glucose cultures ( 9 ). One notable exception is CA_C1339, a proposed xylose importer gene, which has a unique transcription profile with high mRNA levels in cells grown on xylose, moderate levels for those on arabinose, and extremely low levels...”
C5965_09300 sugar porter family MFS transporter from Cronobacter sakazakii
37% identity, 98% coverage
D9T18_05400 sugar porter family MFS transporter from Pseudoalteromonas agarivorans
34% identity, 89% coverage
- Pan-Genomic and Transcriptomic Analyses of Marine Pseudoalteromonas agarivorans Hao 2018 Revealed Its Genomic and Metabolic Features
Jv, Marine drugs 2022 - “...shown in Table 2 , the expression levels of genes encoding sugar transporters (D9T18_18920 and D9T18_05400) at 2 h were higher than those at 24 h. Monosaccharides need to be converted into corresponding nucleotide sugars before they can be used to synthesize EPS. Upon analysis of...”
- “...Annotation Locus Tag 2 h_RPKM 24 h_RPKM glucose/galactose MFS transporter D9T18_18920 210.32 90.40 MFS transporter D9T18_05400 150.59 42.61 marinedrugs-20-00248-t003_Table 3 Table 3 Gene expression related to nucleotide sugar synthesis. Annotation Locus Tag 2 h_RPKM 24 h_RPKM UDP-glucuronate-epimerase D9T18_02060 188.19 45.88 dTDP-4-dehydrorhamnose 3,5-epimerase D9T18_02110 657.00 66.08 dTDP-4-dehydrorhamnose...”
XAC1777 MFS transporter from Xanthomonas axonopodis pv. citri str. 306
34% identity, 88% coverage
INT1_ARATH / Q8VZR6 Inositol transporter 1 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
TC 2.A.1.1.66 / Q8VZR6 The tonoplast H+:Inositol symporter 1, Int1 (mediates efflux from the tonoplast to the cytoplasm (Schneider et al., 2008) (most similar to 2.A.1.1.63 and 2.A.1.1.62) from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
int1 / CAJ00303.1 inositol transporter 1 from Arabidopsis thaliana (see paper)
AT2G43330 INT1 (INOSITOL TRANSPORTER 1); carbohydrate transmembrane transporter/ myo-inositol:hydrogen symporter/ sugar:hydrogen symporter from Arabidopsis thaliana
NP_850393 inositol transporter 1 from Arabidopsis thaliana
37% identity, 84% coverage
- function: Vacuolar inositol-proton symporter involved in the release of myo-inositol from vacuoles. Not involved in glucose or fructose transport.
disruption phenotype: Reduced root length at low concentrations of myo- inositol. - substrates: myo-inositol
- Symplasmic phloem loading and subcellular transport in storage roots are key factors for carbon allocation in cassava
Rüscher, Plant physiology 2024 - “...to the work described in this paper: SUS1 Gramene: AT5G20830 SUS1 Araport: AT5G20830 INT1 Gramene: AT2G43330 INT1 Araport: AT2G43330 phloem AmiGo: PO:0005417 myo-inositol CHEBI: CHEBI:17268 SUS3 Gramene: AT4G02280 SUS3 Araport: AT4G02280 EDTA Gramene: Ethylenediamine tetraacetic acid EDTA Araport: Ethylenediamine tetraacetic acid metabolite CHEBI: CHEBI:25212 TPT Gramene:...”
- Physiological Importance of Molybdate Transporter Family 1 in Feeding the Molybdenum Cofactor Biosynthesis Pathway in Arabidopsis thaliana
Minner-Meinen, Molecules (Basel, Switzerland) 2022 - “...entry vectors. Plasma membrane localised At PIP2a (AT3G53420) [ 62 ] and tonoplast localised INT1 (AT2G43330) [ 63 ] served as negative controls. Cytosolic NSP3 (AT3G16390) [ 79 ] was used as an abundance control [ 28 ]. Fragments of CDS from these controls flanked by...”
- Genome-wide identification, expression, and association analysis of the monosaccharide transporter (MST) gene family in peanut (Arachis hypogaea L.)
Wan, 3 Biotech 2020 - “...Effect pollen and young xylem cells INT1 (AT2G43330) Impacts cell elongation AhMST57 PGLCT (AT5G16150) Affecting chloroplast AtSTP11, was a new member...”
- The Tonoplastic Inositol Transporter INT1 From Arabidopsis thaliana Impacts Cell Elongation in a Sucrose-Dependent Way
Strobl, Frontiers in plant science 2018 - “...Santa Clara, United States) and a GCMS-QP2010S-EI GC/MS-system (Shimadzu, Kyoto, Japan). Accession Numbers INT1 : At2g43330; IMPL1 : At1g31190; MIPS1 : At4g39800; MIOX2 : At2g19800; PI4K : At1g49340; PI4K 1 : At5g64070; PI4K 2 : At5g0935; PIN2 : At5g57090; PIP5K2 : At1g77740; PIP5K9 : At3g09920; PLC2...”
- A Conserved Carbon Starvation Response Underlies Bud Dormancy in Woody and Herbaceous Species
Tarancón, Frontiers in plant science 2017 - “...TRANSPORTER SWEET11 I At1g01720 ATAF1 II At5g23660 SUCROSE EFFLUX TRANSPORTER SWEET12 I At1g69490 NAP I-II-III-IV At2g43330 INOSITOL TRANSPORTER 1 II At5g39610 ORE1 I-II-III At1g22710 SUCROSE TRANSPORTER 1 (SUT1/SUC2) I At5g51070 SAG15 III At1g11260 STP1 I-lll At3g10985 SAG20 III-IV At5g61520 STP3 I At4g02380 SAG21 III At1g77210 STP14...”
- RNA-Seq and Gene Network Analysis Uncover Activation of an ABA-Dependent Signalosome During the Cork Oak Root Response to Drought
Magalhães, Frontiers in plant science 2015 - “...Xyloglucan endotransglycosylase 6 QSDrought_07044 Up AT5G57550 XTH25 Xyloglucan endotransglucosylase/hydrolase 25 Sugar:hydrogen symporter activity QSDrought_00469 Up AT2G43330 ATINT1 ATINT1 INT1 inositol transporter 1 QSDrought_00694 Up AT3G18830 ATPLT5 ATPLT5 ATPMT5 PMT5 polyol/monosaccharide transporter 5 QSDrought_01264 Down AT1G11260 STP1 ATSTP1 STP1 sugar transporter 1 QSDrought_02773 Up AT1G30220 ATINT2 ATINT2...”
- Phylloxera (Daktulosphaira vitifoliae Fitch) alters the carbohydrate metabolism in root galls to allowing the compatible interaction with grapevine (Vitis ssp.) roots
Griesser, Plant science : an international journal of experimental plant biology 2015 - “...GSVIVT01022022001 ERD6-like transporter Vverd6-like8 (at3g05150) 0.77 1.23E05 n.d. n.d. n.d. TC115303 GSVIVT01010741001 Inositol transporter VvINT1 (at2g43330) 0.65 0.0004 1.0 0.7 0.8 TC113429 GSVIVT01021530001 Inositol transporter VvINT2 (at1g30220) 0.71 0.0113 0.9 * 1.1 1.5 ** TC104946 GSVIVT01034886001 Sucrose transporter VvSUC27 (at1g22710) n.s. n.s. 0.7 ** 0.9 1.8...”
- Pre-symptomatic transcriptome changes during cold storage of chilling sensitive and resistant peach cultivars to elucidate chilling injury mechanisms
Pons, BMC genomics 2015 - “...Carbohydrate transport PPN025D11 SLT1 protein AT3G12570 FYD Sugar partioning and homeostasis PPN078G04 Putative membrane transporter AT2G43330 INT1 Sugar partioning and homeostasis Cooper transport PPN025H09 Putative copper-transporting ATPase 3 AT1G63440 HMA5 ion channel PPN023C11 Mechanosensitive ion channel AT5G10490 MSL2 Mg transport PPN001H12 MRS2-5 AT2G03620 MGT3 oligopepetide transport...”
- More
- Routes to the tonoplast: the sorting of tonoplast transporters in Arabidopsis mesophyll protoplasts.
Wolfenstetter, The Plant cell 2012 - GeneRIF: INT1 is correctly localized to the tonoplast, while sorting of the vacuolar sucrose transporter SUC4 is blocked in cis-Golgi stacks.
- Functional and physiological characterization of Arabidopsis INOSITOL TRANSPORTER1, a novel tonoplast-localized transporter for myo-inositol.
Schneider, The Plant cell 2008 - GeneRIF: molecular, physiological, and functional studies demonstrate that INT1 is a tonoplast-localized H(+)/inositol symporter that mediates the efflux of inositol that is generated during the degradation of inositol-containing compounds in the vacuolar lumen
- ITN1, a novel gene encoding an ankyrin-repeat protein that affects the ABA-mediated production of reactive oxygen species and is involved in salt-stress tolerance in Arabidopsis thaliana.
Sakamoto, The Plant journal : for cell and molecular biology 2008 (PubMed)- GeneRIF: Mutation in INT1 impairs abscisic acid signaling which leads to the reduction of reactive oxygen species accumulation under salt-stress conditions.
- Proton-coupled sugar transport in the prototypical major facilitator superfamily protein XylE
Wisedchaisri, Nature communications 2014 - “...AraE (P0AE24); Bacillus subtilis myo-inositol/H + transporter IolT (O34718); Arabidopsis thaliana inositol/H + symporter INT1 (Q8VZR6); Arabidopsis thaliana hexose/H + symporter STP1 (P23586); Parachlorella kessleri hexose/H + symporter HUP1 (P15686); Homo sapiens facilitated glucose transporter GLUT12 (Q8TD20); Homo sapiens H + /myo-inositol transporter GLUT13 (HMIT) (Q96QE2);...”
ZMO0293 sugar transporter from Zymomonas mobilis subsp. mobilis ZM4
ZMO_RS01265 sugar porter family MFS transporter from Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821
37% identity, 89% coverage
- Characterization and Application of the Sugar Transporter Zmo0293 from Zymomonas mobilis
Zhang, International journal of molecular sciences 2023 - “...Sciences 1422-0067 MDPI 10055971 36982961 10.3390/ijms24065888 ijms-24-05888 Article Characterization and Application of the Sugar Transporter Zmo0293 from Zymomonas mobilis Zhang Kun Zhang Wenwen Qin Mengxing Li Yi Wang Hailei * Gomes Joao Paulo Academic Editor Henan Province Engineering Laboratory for Bioconversion Technology of Functional Microbes, College...”
- “...facilitating the diffusion of glucose uptake in Z. mobilis . However, another sugar transporter-encoded gene, ZMO0293 , is poorly characterized. We employed gene deletion and heterologous expression mediated by the CRISPR/Cas method to investigate the role of ZMO0293 . The results showed that deletion of the...”
- Genome-Wide Analyses of Proteome and Acetylome in Zymomonas mobilis Under N2-Fixing Condition
Nisar, Frontiers in microbiology 2021 - “...Supplementary Table S1 ). These include leavansucreases SacB and SacC, sugar transporters (Glf, OprB1, and ZMO0293), ATPase (ZMO0637), and a predicted major intrinsic protein (ZMO0252) that facilitates the passive transport of water, small carbohydrates, and other molecules. Similarly, TonB-dependent receptors and their associated proteins (ExbD and...”
- Cellulosic ethanol production by consortia of Scheffersomyces stipitis and engineered Zymomonas mobilis
Sun, Biotechnology for biofuels 2021 - “...S. stipitis mono-fermentation. At the same time, the gene ZMO0366 (glucose facilitated diffusion protein) and ZMO0293 (sugar porter family MFS transporter) came from Z. mobilis also had about 9.9-, 13.6-fold up-regulation at 9h in the consortium (1:3), respectively. These results above were in consistent with the...”
- Insights into acetate toxicity in Zymomonas mobilis 8b using different substrates
Yang, Biotechnology for biofuels 2014 - “...as a glucose transporter [ 37 ]. A major facilitator superfamily (MFS) family sugar transporter ZMO0293 (EC: 1.3.1.74) is homologous to Glf with a high similarity score of 191. ZMO0293 encodes a symporter with 12 transmembrane domains, which also has high similarity to xylose and arabinose...”
- “...absence or presence of exogenous acetate. In addition, when xylose was the sole carbon source, ZMO0293 was downregulated further in the presence of acetate (Figure 3 ). Furthermore, ZMO0293 was downregulated in late phases (transition or stationary) compared to the log phase with or without the...”
- The Quorum Sensing Auto-Inducer 2 (AI-2) Stimulates Nitrogen Fixation and Favors Ethanol Production over Biomass Accumulation in Zymomonas mobilis
Alencar, International journal of molecular sciences 2021 - “...fermentation [ 8 ]. Glucose internalization is mediated by a specific permease, encoded by gene ZMO_RS01265 [ 17 ]. Once inside the cell, this monosaccharide is degraded by the EntnerDoudoroff glycolytic pathway (ED), followed by pyruvate decarboxylation and acetaldehyde reduction to ethanol [ 18 ]. However,...”
- “...increased glucose uptake, as our transcriptome data show that AI-2-treated cells display increased expression of ZMO_RS01265, a Major Facilitator Superfamily (MFS) permease, located in the bacterial inner membrane, which has been identified as the main glucose transporter in Z. mobilis [ 17 ] (see Supplementary Materials...”
YE2639 putative transporter protein from Yersinia enterocolitica subsp. enterocolitica 8081
36% identity, 95% coverage
XOO_2760 MFS transporter from Xanthomonas oryzae pv. oryzae MAFF 311018
34% identity, 89% coverage
orf9 major facilitator superfamily permease-possibl y sugar transporter from Gramella forsetii KT0803
36% identity, 91% coverage
AT4G36670 mannitol transporter, putative from Arabidopsis thaliana
35% identity, 88% coverage
- The EXO70 inhibitor Endosidin2 alters plasma membrane protein composition in Arabidopsis roots
Li, Frontiers in plant science 2023 - “...NO AT3G08610 NADH dehydrogenase ubiquinone 1 alpha subcomplex subunit 0.30 catabolic process (GO:0009056) 1 NO AT4G36670 POLYOL/MONOSACCHARIDE TRANSPORTER 6 ATPMT6 0.31 response to temperature stimulus (GO:0009266) 12 NO AT3G45650 Protein NRT1/PTR FAMILY 2.7 NPF2.7 0.35 GO:0015698 12 NO AT5G25820 Exostosin family protein 0.35 root morphogenesis (GO:0010015)...”
- Non-volatile signals and redox mechanisms are required for the responses of Arabidopsis roots to Pseudomonas oryzihabitans
Cantabella, Journal of experimental botany 2022 - “...growth: AT4G13420 (HAK5, potassium channel transporter 5); AT1G54970 (RHS7, root hair specific 7, ethylene regulated); AT4G36670 (PMT6, POLYOL/monosaccharide transporter 6); AT5G17860 (CCX4, cation/calcium exchanger); AT1G08430 (ALMT1, aluminium activated malate transporter); AT5G66650 (CMCU, chloroplast-localized mitochondrial calcium uniporter 3); AT2G47160 (BOR1, boron transporter 1); AT5G22410 (RHS18, root hair...”
- Transcriptome Dynamics of Epidermal Reprogramming during Direct Shoot Regeneration in Torenia fournieri
Morinaka, Plant & cell physiology 2021 - “...all three different callus-inducing culture systems of Arabidopsis AGI Primary gene symbol Torenia transcript Significance AT4G36670 POLYOL/MONOSACCHARIDE TRANSPORTER 6 (PMT6) TfB096621 + AT4G36670 POLYOL/MONOSACCHARIDE TRANSPORTER 6 (PMT6) TfB101385 + AT3G07390 AUXIN-INDUCED IN ROOT CULTURES 12 (AIR12) TfA043399 + AT1G21750 PDI-LIKE 1-1 (PDIL1-1) TfA023511 + AT2G15760 TfB102428...”
- “...(GAPC1) TfA002952 + AT1G68560 ALPHA-XYLOSIDASE 1 (XYL1) TfA011629 + AT3G54960 PDI-LIKE 1-3 (PDIL1-3) TfB087184 + AT4G36670 POLYOL/MONOSACCHARIDE TRANSPORTER 6 (PMT6) TfB089190 ns AT3G07390 AUXIN-INDUCED IN ROOT CULTURES 12 (AIR12) TfB097832 + AT3G44750 HISTONE DEACETYLASE 3 (HDA3) TfA014513 + AT4G36670 POLYOL/MONOSACCHARIDE TRANSPORTER 6 (PMT6) TfB077745 ns AT3G44750...”
- Molecular Targets and Biological Functions of cAMP Signaling in Arabidopsis
Xu, Biomolecules 2021 - “...the glucose sensor HXK1 and mediates glucose and ethylene responses [ 189 ]; and PMT6/PLT6 (AT4G36670) was suggested to mediate long distance transport of glucose import [ 190 ]. In addition, we identified TPS7 (AT1G06410) being a hub gene of chocolate1 module ( Figure 7 C),...”
- “...NPF5.12 (AT1G72140), NPF7.2/NRT1.8 (AT4G21680), NRT2.6 (AT3G45060), NPF2.7/NAXT1(AT3G45650), CLC-b (AT3G27170) Sugar SWEET16 (AT3G16690), HKL1 (AT1G50460), PMT6/PLT6 (AT4G36670) Lipid MIOX2 (AT2G19800), ITPK3 (AT4G08170), SFH14 (AT5G56160) Light BG1 (AT5G12050), ERD7 (AT2G17840), KNAT4 (AT5G11060), DFL2 (AT4G03400), PKS1 (AT2G02950), PKS2 (AT1G14280), BRN2 (AT1G03457), TEM1 (AT1G25560), BBX30 (AT4G15248) CO 2 /HCO 3...”
- Genome-wide identification, expression, and association analysis of the monosaccharide transporter (MST) gene family in peanut (Arachis hypogaea L.)
Wan, 3 Biotech 2020 - “...AhMST43 AhMST57 PGLCT (AT5G16150) Affecting chloroplast AtPLT6/AtPMT6 (AT4G36670) Effect pollen and young xylem cells INT1 (AT2G43330) Impacts cell elongation...”
- Genome-Wide Transcriptome Analysis Reveals Conserved and Distinct Molecular Mechanisms of Al Resistance in Buckwheat (Fagopyrum esculentum Moench) Leaves
Chen, International journal of molecular sciences 2017 - “...comp26932_c0_seq1 2.705 AT4G30420 Usually multiple acids move in and out transporter 34 Unknown comp69634_c0_seq1 1.345 AT4G36670 Polyol/monosaccharide transporter 6 Glucose; hexose comp29397_c0_seq1 1.032 AT5G64410 Oligopeptide transporter 4 Oligopeptide comp25749_c0_seq1 3.018 AT1G67940 AtSTAR1 UDP-glucose comp26709_c0_seq1 2.987 comp30641_c0_seq1 2.916 AT2G37330 Aluminum sensitive 3 UDP-glucose comp30389_c0_seq1 2.852 comp8633_c0_seq1 1.022...”
- Transcriptomic analysis of Arabidopsis overexpressing flowering locus T driven by a meristem-specific promoter that induces early flowering
Duplat-Bermúdez, Gene 2016 - “...tissues in AtFTOE plants. Other two upregulated genes were polyol transporter 5 (At3g18830) and 6 (At4g36670) ( Table 2 ) which have the function of transporting polyols and hexoses, mainly glucose and pentoses (ribose). Analysis of transport properties and expression in Arabidopsis indicate that polyol transporters,...”
- “...mitochondria. 1.83 POLYOL TRANSPORTER 5 At3g18830 Membrane, plasma membrane Glucose import 1.63 POLYOL TRANSPORTER 6 At4g36670 Membrane, plasma membrane Glucose import, hexose transmembrane transport 2.07 Table 3 Genes involved in sugar transport repressed in AtFTOE plants. Gene Locus ID Localization Description FC SUC 2 At1g22710 Plasma...”
- Integrated transcriptomics and metabolomics decipher differences in the resistance of pedunculate oak to the herbivore Tortrix viridana L
Kersten, BMC genomics 2013 - “...- Arachis hypogaea 0.1 1.0 -4.2 Gnl|UG|Qro#S57139400 transport. sugars moderately similar ( 241 ) to AT4G36670 mannitol transporter, putative weakly similar ( 109 ) to HEX6_RICCO Hexose carrier protein HEX6 - Ricinus communis 0.1 2.4 -4.2 Gnl|UG|Qro#S57094988 secondary metabolism. isoprenoids. carotenoids. carotenoid cleavage dioxygenase very weakly...”
- More
XP_002313809 polyol transporter 5 from Populus trichocarpa
32% identity, 86% coverage
AL01_02185 sugar porter family MFS transporter from Bombella intestini
36% identity, 92% coverage
CgS9114_04075 sugar porter family MFS transporter from Corynebacterium glutamicum S9114
35% identity, 88% coverage
- Proteome analysis guided genetic engineering of Corynebacterium glutamicum S9114 for tween 40-triggered improvement in L-ornithine production
Jiang, Microbial cell factories 2020 - “...expression plasmid pEC-XK99E was used for the expression of CgS9114_09563 , CgS9114_14252 , CgS9114_09558 , CgS9114_04075 , and CgS9114_11142 . However, only pEC- CgS14252 and pEC- CgS09558 were successfully overexpressed in the strain of C. glutamicum Orn8, and thus generated the strains Orn18 and Orn19. Overexpression...”
- “...ECF transporter 4.397 0.00076343 Up 21.047 UPI0001335098 CgS9114_09558 ABC transporter 3.364 0.00023894 Up 33.102 UPI0002230CC7 CgS9114_04075 Sugar/inositol transporter 2.42 0.0037017 Up 53.663 UPI00000B98E2 CgS9114_11142 RNA polymerase sigma-70 2.285 0.00149636 Up 37.573 UPI00013356FF CgS9114_11567 Hypothetical protein 2 0.00016463 Down 12.641 UPI0002233099 CgS9114_12732 Hypothetical protein 2.079 0.035118 Down...”
b2943 galactose:H+ symporter (galP) from Escherichia coli BW25113
GalP / b2943 galactose:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 6 papers)
GalP / P0AEP1 galactose:H+ symporter from Escherichia coli (strain K12) (see 7 papers)
GALP_ECOLI / P0AEP1 Galactose-proton symporter; Galactose transporter from Escherichia coli (strain K12) (see paper)
TC 2.A.1.1.1 / P0AEP1 Galactose:H+ symporter, GalP. Also transports glucose, xylose, fucose (6-deoxygalactose), 2-deoxygalactose and 2-deoxyglucose) (Henderson and Giddens 1977; from Escherichia coli (strain K12)
NP_417418 galactose:H(+) symporter from Escherichia coli str. K-12 substr. MG1655
b2943 D-galactose transporter from Escherichia coli str. K-12 substr. MG1655
DK885_04375, ETEC_3133 galactose/proton symporter from Escherichia coli
37% identity, 97% coverage
- mutant phenotype: A characterized E. coli protein, see EcoCyc. Not sure why SEED has it as transporting arabinose. .
- function: Uptake of galactose across the boundary membrane with the concomitant transport of protons into the cell (symport system)
- substrates: D-galactose, Galactose
tcdb comment: Henderson et al. 1977; Hernández-Montalvo et al., 2001). Relative substrate affinities of wild-type and mutant forms of the E. coli sugar transporter GalP have been determined by solid-state NMR (Patching et al., 2008). GalP may exist as a trimer with each subunit having a sugar transporting channel (Zheng et al. 2010) - Kinetic analysis of the inhibition of the drug efflux protein AcrB using surface plasmon resonance.
Mowla, Biochimica et biophysica acta. Biomembranes 2018 (PubMed) - The prototypical H+/galactose symporter GalP assembles into functional trimers.
Zheng, Journal of molecular biology 2010 - GeneRIF: Each monomer in the trimer forms its own channel, but an additional cavity (10 approximately 15 A in diameter) is apparent at the 3-fold axis of the oligomer.
- Unfolding free energy of a two-domain transmembrane sugar transport protein.
Findlay, Proceedings of the National Academy of Sciences of the United States of America 2010 - GeneRIF: Unfolding free energy of a two-domain transmembrane sugar transport protein, GalP.
- Repression of galP, the galactose transporter in Escherichia coli, requires the specific regulator of N-acetylglucosamine metabolism.
El, Molecular microbiology 2009 (PubMed)- GeneRIF: galP is repressed by a combination of NagC, GalR and GalS.
- Relative substrate affinities of wild-type and mutant forms of the Escherichia coli sugar transporter GalP determined by solid-state NMR.
Patching, Molecular membrane biology 2008 (PubMed)- GeneRIF: effects of the galP mutations W56F, W239F, R316W, T336Y and W434F on glucose binding
- Contribution of Stenotrophomonas maltophilia MfsC transporter to protection against diamide and the regulation of its expression by the diamide responsive repressor DitR
Boonyakanog, PloS one 2022 - “...AraE (P0AE24), Bcr (P28246), Blt (P39843), Bmr (P33449), CmlA (Q83V15), EmrD (P31442), EmrD-3 (C3LUT7), GalP (P0AEP1), LacY (P02920), LmrP (Q48658), MdfA (P0AEY8), MdtG (P25744), MhpT (P77589), NorA (P0A0J7), TetA (P02981), XylE (P0AGF4), YicM (J7R7Q1). mfsC mutant is susceptible to diamide To evaluate the physiological function of...”
- Proton-coupled sugar transport in the prototypical major facilitator superfamily protein XylE
Wisedchaisri, Nature communications 2014 - “...XylE (P0AGF4); Lactobacillus brevis D -xylose/H + symporter XylT (O52733); Escherichia coli galactose permease GalP (P0AEP1); Escherichia coli arabinose permease AraE (P0AE24); Bacillus subtilis myo-inositol/H + transporter IolT (O34718); Arabidopsis thaliana inositol/H + symporter INT1 (Q8VZR6); Arabidopsis thaliana hexose/H + symporter STP1 (P23586); Parachlorella kessleri hexose/H...”
- Automated characterization and analysis of expression compatibility between regulatory sequences and metabolic genes in Escherichia coli
Wen, Synthetic and systems biotechnology 2024 - “...b2388 glk Glucokinase b2913 serA Phosphoglycerate dehydrogenase b2914 rpiA Ribose-5-phosphate isomerase A b2935 tktA Transketolase b2943 galP Galactose/H+ symporter b3041 ribB 3,4-Dihydroxy-2-butanone-4-phosphate synthase b3916 pfkA 6-Phosphofructokinase 1 b3919 tpiA Triose-phosphate isomerase b4025 pgi Glucose-6-phosphate isomerase b3956 ppc Phosphoenolpyruvate carboxylase b4090 rpiB Ribose-5-phosphate isomerase b3386 rpe Ribulose...”
- “...wide range of fluorescence intensities with different regulatory sequences. However, the fluorescence levels of genes b2943 (encoding a galactose:H + symporter) and b3952 (encoding a pyruvate formate lyase activating enzyme) remained relatively low. This may be due to these genes being subject to relatively strict regulation....”
- Systems Biology Approach to Bioremediation of Nitroaromatics: Constraint-Based Analysis of 2,4,6-Trinitrotoluene Biotransformation by Escherichia coli
Iman, Molecules (Basel, Switzerland) 2017 - “...GLCt2pp D-glucose transport in via proton symport (periplasm) glc-D[p] + h[p] -> glc-D[c] + h[c] b2943 NH4tpp Ammonia reversible transport (periplasm) nh4[p] <=> nh4[c] (b0451 or s0001) TPI Triose-phosphate isomerase dhap[c] <=> g3p[c] b3919 GLYCDx Glycerol dehydrogenase glyc[c] + nad[c] -> dha[c] + h[c] + nadh[c]...”
- Combinatorial strategies for improving multiple-stress resistance in industrially relevant Escherichia coli strains
Lennen, Applied and environmental microbiology 2014 - “...Description Fold change b0463 b0121 b2095 b4240 b3415 b2664 b2943 ECD_01942 b2028 b4114 b2845 b2663 acrA speE gatZ treB gntT csiR galP vioA ugd eptA yqeG gabP...”
- Transcription, translation, and the evolution of specialists and generalists
Zhong, Molecular biology and evolution 2009 - “...in Ancestors TD2 and TD10 b-Number b0719 b0879 b1639 b2943 b3287 b3306 b3508 SE, standard error. log2 LU/MG SE Gene Function 0.45 0.51 0.66 0.52 0.36 0.66...”
- Physiological studies of Escherichia coli strain MG1655: growth defects and apparent cross-regulation of gene expression
Soupene, Journal of bacteriology 2003 - “...resulted in higher levels of expression of: galP (b2943), which codes for a low-affinity galactose transporter; the mglBAC operon (b2150 to b2148), which codes...”
- “...12 10 2.1 2.9 6.4 3.6 1.5 1.4 b2151 galS 1.3 3.3 b2943 galP 2.8 3.9 b2150 b2149 b2148 mglB mglA mglC 3.6 2.6 0.8 13 7.3 4.9 b4120 b4119 b4118 melB melA melR 1.0...”
- Escherichia coli gene expression responsive to levels of the response regulator EvgA
Masuda, Journal of bacteriology 2002 - “...b0553 nmpC b2167 b2168 b2169 fruA fruK fruB b2943 galP Mean Outer membrane porin protein; locus of qsr prophage PTS system, fructose-specific transport protein...”
- A Novel SXT/R391 Integrative and Conjugative Element Carries Two Copies of the blaNDM-1 Gene in Proteus mirabilis
He, mSphere 2021 - “...encoding 4-oxalomesaconate tautomerase (DK885_16125), bifunctional aldehyde dehydrogenase (DK885_12690), hydrogenase-4 component J (DK885_06720), and galactose-proton symporter (DK885_04375) was noticeable, whereas genes for multidrug resistance protein (MdtL), guanine/hypoxanthine permease (GhxQ), and cold shock protein (CspB) were expressed at lower levels in XH1814. We also compared gene expression levels...”
- The molecular basis for control of ETEC enterotoxin expression in response to environment and host
Haycocks, PLoS pathogens 2015 - “...) ( ygfI ) 3382158 TGTGA TCTACAA CAC G ETEC_3126 cmtB 3390811 TGTGA TTTGCT TCACA ETEC_3133 galP 3408173 TGTGA TGTGGA T A ACA ETEC_3154 nupG 3442697 TGTGA TGATTG TC G CA ETEC_3186 ETEC-specific 3558573 A GTGA TTTGGC TCACA ETEC_3291 ygiS 3580767 A GTGA CTTGCA TCACA (...”
PFREUD_19110 MFS transporter from Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1
35% identity, 81% coverage
- A unique in vivo experimental approach reveals metabolic adaptation of the probiotic Propionibacterium freudenreichii to the colon environment
Saraoui, BMC genomics 2013 - “...CUST_332_PI426428742 PFREUD_15480 ftsQ Cell division protein FtsQ 1.7 Cell division 4,1 3,0E-07 1,5 3,5E-01 CUST_1474_PI426428742 PFREUD_19110 iolT3 iolT3 (myo-inositol transporter iolT3) 2.1 Metabolism of carbohydrates and related molecules 3,4 7,0E-08 5,9 2,8E-02 CUST_1811_PI426428742 PFREUD_19080 iolB iolB (Myo-inositol catabolism IolB protein) 2.1.1 Specific carbohydrate metabolic pathway 2,4...”
STM14_3735 galactose/proton symporter from Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S
37% identity, 97% coverage
ZPR_0446 xylose permease from Zunongwangia profunda SM-A87
36% identity, 92% coverage
GOX0649 Sugar-proton symporter from Gluconobacter oxydans 621H
35% identity, 91% coverage
TC 2.A.1.1.54 / Q8NL90 Myo-Inositol (Km=0.45mM) uptake porter, IolT2 (Krings et al., 2006). Can not transport D-glucose from Corynebacterium glutamicum (Brevibacterium flavum) (see paper)
cg3387 major facilitator superfamily permease from Corynebacterium glutamicum ATCC 13032
NCgl2953 sugar porter family MFS transporter from Corynebacterium glutamicum ATCC 13032
34% identity, 88% coverage
- substrates: myo-inositol
- Physiological Response of Corynebacterium glutamicum to Indole
Walter, Microorganisms 2020 - “...45 ng of PCR amplified and purified intergenic fragment between start codon of cg3388 and cg3387 (429 bp, using oligonucleotides cg3388_EMSA_F and cg3388_EMSA_R) in band shift buffer (50 mM TrisHCl, 4% ( v / v ) glycerol, 50 mM KCl, 10 mM MgCl 2 , 0.5...”
- Impact of CO2/HCO3- Availability on Anaplerotic Flux in Pyruvate Dehydrogenase Complex-Deficient Corynebacterium glutamicum Strains
Krüger, Journal of bacteriology 2019 (secret) - Phosphotransferase system-independent glucose utilization in corynebacterium glutamicum by inositol permeases and glucokinases
Lindner, Applied and environmental microbiology 2011 - “...In-frame deletions of iolT1 (cg0223) and iolT2 (cg3387) In-frame deletions of iolT1 (cg0223), iolT2 (cg3387), and hpr (cg2121) L-Lysine-producing strain;...”
- “...Derived from pEKEx3, for regulated expression of iolT2 (cg3387) of C. glutamicum Chlr; C. glutamicum/E. coli shuttle vector (Ptac , lacIq; pBL1, oriVC....”
- Two-component systems of Corynebacterium glutamicum: deletion analysis and involvement of the PhoS-PhoR system in the phosphate starvation response
Kocan, Journal of bacteriology 2006 - “...cg3227 cg3281 cg3282 cg3286 cg3287 cg3303 cg3327 cg3335 cg3386 cg3387 cg3390 cg3391 cg3404 NCBI no. c 730 KOCAN ET AL. J. BACTERIOL. The transcriptional start...”
- A Futile Metabolic Cycle of Fatty Acyl-CoA Hydrolysis and Resynthesis in Corynebacterium glutamicum and Its Disruption Leading to Fatty Acid Production
Ikeda, Applied and environmental microbiology 2021 - “...a carbon source due to the existence of an additional transporter encoded by iolT2 (Cgl3058, NCgl2953). Fatty acid production. A 3-ml sample of the seed culture grown in BY medium to the mid-exponential phase at 30C was inoculated into a 300-ml baffled Erlenmeyer flask containing 30ml...”
- High-yield production of L-serine through a novel identified exporter combined with synthetic pathway in Corynebacterium glutamicum
Zhang, Microbial cell factories 2020 - “...4.84 Efflux system protein NCgl0155 9.11 43.69 4.79 5-Dehydro-2-deoxygluconokinase NCgl0014 10.02 47.76 4.76 Hypothetical protein NCgl2953 7.68 35.80 4.66 Sugar permease NCgl2744 12.26 55.19 4.50 Hypothetical protein NCgl2970 15.22 67.51 4.43 ABC transporter periplasmic component NCgl0608 23.06 100.35 4.35 ABC transporter permease NCgl0258 4.51 19.50 4.32...”
- Genome-wide investigation of aromatic acid transporters in Corynebacterium glutamicum
Chaudhry, Microbiology (Reading, England) 2007 (PubMed)- “...genes (ncgl1031, ncgl2302, ncgl2325, ncgl2326, ncgl2922 and ncgl2953) encoding putative transport proteins are involved in uptake of various aromatic compounds...”
- “...hydK/ncgl2953 mutant failed, so the function of ncgl2953 remains unclear. INTRODUCTION Membrane transport in bacteria not only maintains a suitable environment...”
- Genetic characterization of the resorcinol catabolic pathway in Corynebacterium glutamicum
Huang, Applied and environmental microbiology 2006 - “...repressors, but only NCgl1110 was transcribed and functional. NCgl2953 encoded a putative transporter, but disruption of this gene did not affect resorcinol...”
- “...degradation by C. glutamicum. The function of NCgl2953 remains unclear. the understanding of microbial processes that govern the metabolism of aromatic...”
- Two-component systems of Corynebacterium glutamicum: deletion analysis and involvement of the PhoS-PhoR system in the phosphate starvation response
Kocan, Journal of bacteriology 2006 - “...NCgl2864 NCgl2865 NCgl2877 NCgl2897 NCgl2904 NCgl2952 NCgl2953 NCgl2956 NCgl2957 NCgl2970 Annotation Gene Enzyme II of sucrose phosphotransferase system...”
- Characterization of myo-inositol utilization by Corynebacterium glutamicum: the stimulon, identification of transporters, and influence on L-lysine formation
Krings, Journal of bacteriology 2006 - “...NCgl2477 NCgl2865 NCgl2894 NCgl2904 NCgl2951 NCgl2952 NCgl2953 NCgl2955 NCgl2956 NCgl2957 NCgl2958 NCgl2959 NCgl2961 Cgl0030 Cgl0158 Cgl0160 Cgl0161 Cgl0162...”
- Global expression profiling and physiological characterization of Corynebacterium glutamicum grown in the presence of L-valine
Lange, Applied and environmental microbiology 2003 - “...precursor tla-I (E. coli plasmid RZA9) 3431 NCgl2953 Strong similarity to D-xylose proton symporter xylT (Lactobacillus brevis) 3443 NCgl2960 Weak similarity...”
GOX1971 Galactose-proton symporter from Gluconobacter oxydans 621H
35% identity, 94% coverage
Z4288 galactose-proton symport of transport system from Escherichia coli O157:H7 EDL933
ECs3819 galactose-proton symport of transport system from Escherichia coli O157:H7 str. Sakai
38% identity, 95% coverage
XP_021757156 plastidic glucose transporter 4-like from Chenopodium quinoa
36% identity, 78% coverage
- Salinity Effects on Guard Cell Proteome in Chenopodium quinoa
Rasouli, International journal of molecular sciences 2021 - “...channel subunit beta Potassium XP_021753247 monosaccharide-sensing protein 2-like Sugar XP_021726328 sugar carrier protein C-like Sugar XP_021757156 plastidic glucose transporter 4-like Sugar XP_021760460 sucrose transport protein-like isoform X1 Sucrose XP_021752898 chloride channel protein CLC-b-like anions XP_021739774 ATPase ASNA1 homolog anions XP_021772050 ADP, ATP carrier protein 1, mitochondrial-like...”
AL01_03450 sugar porter family MFS transporter from Bombella intestini
35% identity, 94% coverage
NP_708708 MFS family galactose:proton symporter from Shigella flexneri 2a str. 301
37% identity, 96% coverage
RM25_RS08970 MFS transporter from Propionibacterium freudenreichii subsp. freudenreichii
35% identity, 81% coverage
ARAE_BACSU / P96710 Arabinose-proton symporter; Arabinose transporter from Bacillus subtilis (strain 168) (see 4 papers)
TC 2.A.1.1.55 / P96710 L-arabinose:proton symporter, AraE (Sa-Nogueira and Ramos, 1997). Also transports xylose, galactose and α-1,5 arabinobiose from Bacillus subtilis (see 4 papers)
36% identity, 91% coverage
- function: Uptake of L-arabinose across the cytoplasmic membrane with the concomitant transport of protons into the cell (symport system) (PubMed:9401028). In the presence of inducing amounts of L-arabinose, can import both D-galactose and D-xylose (PubMed:9620981). Can also transport the disaccharide alpha-1,5-arabinobiose (PubMed:20693325).
catalytic activity: H(+)(in) + L-arabinose(in) = H(+)(out) + L-arabinose(out) (RHEA:28951)
catalytic activity: D-galactose(in) + H(+)(in) = D-galactose(out) + H(+)(out) (RHEA:29019)
catalytic activity: D-xylose(in) + H(+)(in) = D-xylose(out) + H(+)(out) (RHEA:28959)
disruption phenotype: Deletion of the gene does not affect growth on glucose, but the mutant cannot grow in the presence of arabinose. Deletion has a negative effect on the ability of the mutant to grow on alpha-1,5-arabinobiose. AraE/araN double mutant is unable to grow in the presence of alpha-1,5-arabinobiose. - substrates: Alpha-1,5 Arabinobiose, Galactose, H+, L-arabinose, Xylose
- Bacillus cereus efflux protein BC3310 - a multidrug transporter of the unknown major facilitator family, UMF-2
Kroeger, Frontiers in microbiology 2015 - “...(Q5WAS7), Pseudomonas syringae (Q887F7), Clostridium perfringens (Q46305) and the sugar transporter AraE from B. subtilis (P96710) as an outgroup were used to build the tree. Posterior probability values are shown at each node and the bar represents the expected number of amino acid substitutions per site....”
AT2G20780 mannitol transporter, putative from Arabidopsis thaliana
33% identity, 85% coverage
- Transcriptomic and proteomic approach to identify differentially expressed genes and proteins in Arabidopsis thaliana mutants lacking chloroplastic 1 and cytosolic FBPases reveals several levels of metabolic regulation
Soto-Suárez, BMC plant biology 2016 - “...family proteins (At3g05155, At4g04760, At3g19940) were up-regulated in cyfbp rosettes, and only a mannitol transporter (At2g20780) was down-regulated. Finally, a carbohydrate transmembrane transporter (At1g08930) and two UDP-galactose transporters (At4g23010 and At3g59360) were up-regulated in cyfbp roots, whereas two monosaccharide transporters were down-regulated in this organ (At1g34580...”
- Identification of miRNAs and Their Targets in the Liverwort Marchantia polymorpha by Integrating RNA-Seq and Degradome Analyses
Lin, Plant & cell physiology 2016 - “...LW9386 NA AT1G48380 HYPOCOTYL 7 LW28862 NA EFJ23241 NA LW798 NA AT2G27290 NA LW8919 NA AT2G20780 Carbohydrate transmembrane transporter activity LW3390 NA AT1G55350 DEFECTIVE KERNEL 1 LW2282 NA AT4G38160 PIGMENT DEFECTIVE 191 LW3379 NA AT1G75200 Radical SAM domain-containing protein LW769 NA AT5G47390 MYB HYPOCOTYL ELONGATION-RELATED Mpo-miR11698.1...”
- A meta-analysis reveals the commonalities and differences in Arabidopsis thaliana response to different viral pathogens
Rodrigo, PloS one 2012 - “...performed in Col-0. Only seven genes ( At1g14970 , At1g50250 , At1g78170 , At2g16700 , At2g20780 , At3g45860 , and At4g12520 ) had expression levels that were significantly affected by the host ecotype (Mann-Whitney test). However, if a correction for multiple testing (FDR procedure; adjusted P...”
- The Vitis vinifera sugar transporter gene family: phylogenetic overview and macroarray expression profiling
Afoufa-Bastien, BMC plant biology 2010 - “...(AtINT3), At4g16480 (AtINT4), At3g03090 (AtVGT1), At5g17010 (AtVGT2), At5g59250 (AtVGT3), At2g16120 (AtPMT1), At2g16130 (AtPMT2), At2g18480 (AtPMT3), At2g20780 (AtPMT4), At3g18830 (AtPMT5), At4g36670 (AtPMT6); for Vitis ones see Additional file 1 . Vitis ORFs names were simplified, Vv indicating GSVIVT000. Vitis vinifera putative Polyol/Monosaccharide Transporters (VvPMT; subfamily III) Five...”
B0W47_14370 sugar porter family MFS transporter from Komagataeibacter nataicola
37% identity, 93% coverage
- Complete genome sequence of the cellulose-producing strain Komagataeibacter nataicola RZS01
Zhang, Scientific reports 2017 - “...widely used substrate for industrial production, glucose could be taken up by a sugar symporter (B0W47_14370). Owing to the lack of the gene encoding phosphofructokinase (EC 2.7.1.11), RZS01 has an incomplete Embden-Meyerhof-Parnas pathway, as has been reported in Acetobacter pasteurianus 386B 6 , Gluconacetobacter diazotrophicus Pal5...”
- Reconstruction of a Genome-scale Metabolic Network of Komagataeibacter nataicola RZS01 for Cellulose Production
Zhang, Scientific reports 2017 - “...most widely available carbon source, glucose was easily taken up by sugar permeases, encoded by B0W47_14370 . The Embden-Meyerhof-Parnas pathway is incomplete in strain RZS01 because of a lack of the gene encoding phosphofructokinase (EC 2.7.1.11). Nevertheless, the genes encoding enzymes of the PPP were present,...”
pGlcT / Q56ZZ7 glucose transporter from Arabidopsis thaliana (see 4 papers)
PLST4_ARATH / Q56ZZ7 Plastidic glucose transporter 4; AtpGlcT from Arabidopsis thaliana (Mouse-ear cress) (see paper)
TC 2.A.1.1.102 / Q56ZZ7 Plastidic glucose transporter 4 (AtpGlcT) from Arabidopsis thaliana (see 5 papers)
NP_850828 plastidic GLC translocator from Arabidopsis thaliana
AT5G16150 PGLCT (PLASTIDIC GLC TRANSLOCATOR); carbohydrate transmembrane transporter/ sugar:hydrogen symporter from Arabidopsis thaliana
36% identity, 78% coverage
- function: May be involved in the efflux of glucose towards the cytosol.
- substrates: glucose
- The novel chloroplast glucose transporter pGlcT2 affects adaptation to extended light periods.
Valifard, The Journal of biological chemistry 2023 - GeneRIF: The novel chloroplast glucose transporter pGlcT2 affects adaptation to extended light periods.
- Role of the plastidic glucose translocator in the export of starch degradation products from the chloroplasts in Arabidopsis thaliana.
Cho, The New phytologist 2011 (PubMed)- GeneRIF: pGlcT, together with MEX1, contributes significantly to the export of starch degradation products from chloroplasts in A. thaliana leaves and and that this starch-mediated pathway for photoassimilate export via pGlcT and MEX1 is essential for the growth and development of A. thaliana. [pGlcT]
- Do mitochondria use efflux pumps to protect their ribosomes from antibiotics?
Islam, Microbiology (Reading, England) 2023 - “...9E^121** Q9SYQ1, 0.00014 A0A286YF51, 0.0019 [ 73 ] TPO1 Polyamine transporter 1 MFS G1UAY0, 1.9E^141# Q56ZZ7, 0.00017 Q6ZMD2, 9.2E^6 [ 40 ] TPO3 Polyamine transporter 3 MFS Q9C0R8, 6.1E^98# A0A1I9LP99, 7.5E^5 Q7L0J3, 0.0047 [ 40, 73 ] *Information adapted from the Saccharomyces Genome Database (SGD). https://www.yeastgenome.org/....”
- “...MFS T2AWG3, 0.0014 Q8GYF4, 1.4E^24 B3KT41, 0.0022 [ 79 ] NCU09551 Q7S2B0 MFS G1UAY0, 2.3E^6 Q56ZZ7, 2.3E^7 Q8NBP5, 8.4E^9 [ 78 ] NCU10021 Q7S0I5 MFS Q8J2J7, 8.1E^102 Q9FMX3, 2.3E^55 Q96QE2, 2.8E^41 [ 78 ] *Information gathered from NCBI Protein BLAST, algorithm: PSI-BLAST ( https://www.ncbi.nlm.nih.gov/ ) and...”
- Microsome-associated proteome modifications of Arabidopsis seedlings grown on board the International Space Station reveal the possible effect on plants of space stresses other than microgravity
Mazars, Plant signaling & behavior 2014 - “...protein Transporters P23586 AT1G11260 0.370 sugar transporter 1 Q8LGU1 AT3G21250 0.456 multidrug resistance-associated protein 6 Q56ZZ7 AT5G16150 0.523 Plastidic glucose transporter 4 Q53XH7 AT5G62670 0.553 H(+)-ATPase 11 Q94FB9 AT4G39850 0.559 ABC transporter D family member 1 Q9SE45 AT2G38760 0.587 annexin D3 Aquaporins Q41975 AT4G17340 0.219 putative...”
- The novel chloroplast glucose transporter pGlcT2 affects adaptation to extended light periods
Valifard, The Journal of biological chemistry 2023 - “...of the MST-type sugar transporter family in Arabidopsis revealed that pGlcT (encoded by the gene At5g16150 ) is one of four closely related carrier isoforms representing an independent MST subgroup ( 3 ). The next homolog to pGlcT is the protein encoded by the gene At1g05030...”
- “...Alignment of pGlcT2 with other sugar transporters (VGT1: At3g03090 , pSUT: At5g59250 , and pGLCT: At5g16150 ) was done using MEGA11 software ( 74 ) based on ClustalW ( 75 ) alignment of the corresponding amino acid sequences. The alignment was visualized using GeneDoc ( 76...”
- Nucleotide Imbalance, Provoked by Downregulation of Aspartate Transcarbamoylase Impairs Cold Acclimation in Arabidopsis
Bellin, Molecules (Basel, Switzerland) 2023 - “...1.97 2.05 1.48 1.49 Mt, P adenine nucleotide AT5G66380 FOLT1 0.76 1.05 0.65 PL folate AT5G16150 pGlcT 0.44 0.87 1.03 1.20 0.34 PL hexose AT1G68570 NPF3.1 2.69 2.35 0.66 0.72 PL nitrite AT4G32400 BT1-like 2.01 1.58 0.70 0.72 PL nucleotide AT1G61800 GPT2 5.90 7.61 0.39 1.65...”
- Genome-Wide Association Study to Identify Possible Candidate Genes of Snap Bean Leaf and Pod Color
Celebioglu, Genes 2023 - “...706,796 11.61 0.36 31.60 10.9 7.76 10 9 Phvul.008G006600 AT5G65560 Phvul.008G006700 AT5G38720 Phvul.008G006800 AT2G19540 Phvul.008G007500 AT5G16150 Phvul.008G007600 AT2G39060 Phvul.008G007700 AT5G16180 Phvul.008G008400 AT1G66840 5-593 1 G/T H.2020 50,939,307 27.26 0.08 75.89 29.3 1.47 10 23 Pv5-593.01G220900 AT5G26600 Pv5-593.01G221300 AT1G56720 Pv5-593.01G221400 Pv5-593.01G221500 AT1G09430 Pv5-593.01G221600 AT3G07100 Pv5-593.01G221800 AT1G56700 Pv5-593.01G221900...”
- An expanded role for the transcription factor WRINKLED1 in the biosynthesis of triacylglycerols during seed development
Kuczynski, Frontiers in plant science 2022 - “...PGI 1 (phosphoglucose isomerase, AT4G24620) (p) +20(+) 2.90.6 0.92 0.94 ** PGLCT (plastidic glucose translocator, AT5G16150) +45() 23.94.7 1.00 0.82 * PGLM 1 (phosphoglyceromutase, AT1G22170) (p) +104(+) 1.91.3 0.67 1.00 ** PGLM 2 (phosphoglyceromutase, AT1G78050) (p) +78(+) 6.74.1 1.00 0.97 ** PK p PK- (Pyruvate kinase...”
- Genome-wide identification, expression, and association analysis of the monosaccharide transporter (MST) gene family in peanut (Arachis hypogaea L.)
Wan, 3 Biotech 2020 - “...Regulate arsenic accumulation AhMST76 AhMST43 AhMST57 PGLCT (AT5G16150) Affecting chloroplast AtPLT6/AtPMT6 (AT4G36670) Effect pollen and young xylem cells INT1...”
- Transcriptional Plasticity of Autophagy-Related Genes Correlates with the Genetic Response to Nitrate Starvation in Arabidopsis Thaliana
Bedu, Cells 2020 - “...0.079 0.022 19.4% 0.005 ** GLU1 At5g04140 6.208 1.835 6.972 2.141 12.3% 0.026 * GLT At5g16150 0.284 0.110 0.372 0.139 31.0% 0.000 *** * p < 0.05, ** p < 0.01, *** p < 0.001, ns = not statistically significant. cells-09-01021-t002_Table 2 Table 2 Averages of...”
- Pan- and core- gene association networks: Integrative approaches to understanding biological regulation
Wirojsirasak, PloS one 2019 - “...a-Glucosidase-like 3 At5g11720 AGL4 a-Glucosidase-like 4 At1g68560 AGL5 a-Glucosidase-like 5 At5g46110 TPT1 Triose phosphate translocator At5g16150 GLT1 Glucose transporter At5g17520 MEX1 Maltose exporter The consensus-based network, proposed herein as core -GAN, is generally considered a reliable network because the constituents are supported by more than one...”
- Dynamics of metabolic responses to periods of combined heat and drought in Arabidopsis thaliana under ambient and elevated atmospheric CO2
Zinta, Journal of experimental botany 2018 - “...at4g10120; ADP glucose pyrophosphorylase, EC 2.7.7.27, at5g19220), and sugar transporters (sucrose-proton symporter 1/plastidic GLC translocator, at5g16150; glucose-6-phosphate translocator, at5g46110). Elevated CO 2 dampened this effect (see Supplementary Fig. S1a ). Glycolysis-related genes were generally down-regulated under stress ( Fig. S1b ). Transcripts of raffinose synthesis genes...”
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LGG_02683 D-xylose proton-symporter / bicyclomycin resistance protein TcaB / metabolite transport protein CsbC from Lactobacillus rhamnosus GG
37% identity, 95% coverage
LOC100852699 polyol transporter 5 from Vitis vinifera
33% identity, 86% coverage
plt2 / CAD58710.1 polyol transporter from Plantago major (see paper)
32% identity, 83% coverage
MSMEG_5559 metabolite/sugar transport protein from Mycobacterium smegmatis str. MC2 155
34% identity, 93% coverage
- Azido Inositol Probes Enable Metabolic Labeling of Inositol-Containing Glycans and Reveal an Inositol Importer in Mycobacteria
Hodges, ACS chemical biology 2023 - “...on their similarity to known inositol importer genes, including MSMEG_5166 , MSMEG_0190 , MSMEG_5161 , MSMEG_5559 , and MSMEG_4462 . We found that when silenced, these genes did not prevent growth on 1 mM inositol in the presence of ATc, indicating that these genes are unlikely...”
- Characterization of Mycobacterium smegmatis sigF mutant and its regulon: overexpression of SigF antagonist (MSMEG_1803) in M. smegmatis mimics sigF mutant phenotype, loss of pigmentation, and sensitivity to oxidative stress
Singh, MicrobiologyOpen 2015 - “...2.22/0.91 MSMEG_5343 a Conserved hypothetical protein 3.09/1.07 GTTTN 16 GGCTA 35 MSMEG_5374 Glutamateammonia ligase 2.22/0.03 MSMEG_5559 Metabolite/sugar transport protein 2.83/0.35 GTTTN 16 GGGTA 39 MSMEG_5623 Lcarnitine dehydratase 3.24/1.20 GTTCN 15 GGGCA 51 MSMEG_5731 Transcriptional regulator, GntR family 2.31/0.25 GTCTN 18 GGGAT 785 MSMEG_6507 Glycogen debranching enzyme...”
- The SigF regulon in Mycobacterium smegmatis reveals roles in adaptation to stationary phase, heat, and oxidative stress
Hümpel, Journal of bacteriology 2010 - “...MSMEG_4737 MSMEG_5011 MSMEG_5376 MSMEG_5434 MSMEG_5499 MSMEG_5559 MSMEG_5580d MSMEG_5754 MSMEG_5773 MSMEG_5872 MSMEG_5907 MSMEG_6091 MSMEG_6199 MSMEG_6427...”
- A genomic view of sugar transport in Mycobacterium smegmatis and Mycobacterium tuberculosis
Titgemeyer, Journal of bacteriology 2007 - “...found four homologs (msmeg_2966, msmeg_4098, msmeg_4182, and msmeg_5559), of which msmeg_4182 exhibited 53% identity to glucose symporters (Fig. 2). msmeg_4182...”
AT2G18480 mannitol transporter, putative from Arabidopsis thaliana
35% identity, 82% coverage
- Root-based inorganic carbon uptake increases the growth of Arabidopsis thaliana and changes transporter expression and nitrogen and sulfur metabolism
Gamarra, Frontiers in plant science 2024 - “...0.49 31.46 Carnitine transporter AT1G73220 Organic cation/carnitine transporter 1 OCT1 -1.11 0.46 51.96 Polyol transporter AT2G18480 Probable polyol transporter 3 PLT3 -1.18 0.44 137.94 Boron transporter AT1G74810 Putative boron transporter 5 BOR5 -1.55 0.34 10.90 Ascorbate transporter AT1G49960 Nucleobase-ascorbate transporter 4 NAT4 -1.65 0.32 229.76 Aminoacid...”
- Genomic methylation patterns in pre-meiotic gynoecia of wild-type and RdDM mutants of Arabidopsis
Ortiz-Vasquez, Frontiers in plant science 2023 - “...Supplementary Table S8 ). Four are hypomethylated in ago4 but hypermethylated in ago9 and rdr6 (At2g18480; At3g02610; At4g15440; and At5g17600; encoding for the probable polyol transporter PLT3, the acyl-acyl carrier protein desaturase AAD2, the cytochrome CYP74B2, and the Arabidopsis toxic yeast protein ATL52, respectively; Supplementary Table...”
- Transcriptome analysis of Pará rubber tree (H. brasiliensis) seedlings under ethylene stimulation
Nakano, BMC plant biology 2021 - “...AT1G77210 AtSTP14 3.04 3.23 2.81 H+-Symporter family for polyols and monosaccharides (plasma membrane) 0 bx046600 AT2G18480 AtPLT3 6.25 6.26 6.34 Putative monosaccharide transporter family (ERD-group=induced by early dehydration) 0 bx021636 AT2G48020 Major facilitator superfamily protein 2.01 2.93 2.45 0 bx037209 AT2G48020 Major facilitator superfamily protein 2.01...”
- Heat-Induced Oxidation of the Nuclei and Cytosol
Babbar, Frontiers in plant science 2020 - “...(AT3G46900), RPF6 (AT1G63130), BGLU28 (AT2G44460), VSP1 (AT5G24780), HP-hypothetical protein (AT2G19970), SBT4.1 (AT5G59120), JAL23 (AT2G39330), PLT3 (AT2G18480), TAS1B (AT1G50055), HSP22 (AT4G10250), HSFA2 (AT2G26150), HSP17.6C (AT1G53540), HSP17.6A (AT5G12030), HSFA7B (AT3G63350), HSP23.6 (AT4G25200), HSP17.6A (AT5G12030), NAD6 (ATMG00270), HSP17.4A (AT3G46230), HSP17.6 (AT5G12020), natRNA (AT3G07365), CALS12 (AT5G03550), HSP21 (AT4G27670), RLP1 (AT1G07390),...”
- Natural genetic variation in Arabidopsis for responsiveness to plant growth-promoting rhizobacteria
Wintermans, Plant molecular biology 2016 - “...the transport of purine and derivatives such as cytokinins across the plasma membrane SFW 5.22 At2G18480 Major facilitator superfamily protein Carbohydrate transmembrane transporter activity; plant structure SFW 5.58 At2G20570 Golden2-like 1 (GLK1) Transcription factor activity; regulates expression of the photosynthetic apparatus (with GLK2) SFW 5.46 At4G09730...”
- “...Rubisco biogenesis-related DEAD box protein RH39 (Nishimura et al. 2010 ), carbohydrate transmembrane transport protein At2G18480, Nitrilase-like protein 1 (NLP1) (Kusano et al. 2008 ), and the photorespiration-related mitochondrial serine hydroxymethyltransferase SHM2 (Engel et al. 2011 ; Voll et al. 2006 ) (Table 1 ). Overall,...”
- Global Transcriptome Analysis Reveals Distinct Aluminum-Tolerance Pathways in the Al-Accumulating Species Hydrangea macrophylla and Marker Identification
Chen, PloS one 2015 - “...3.4 At1g75840 ATROP4 (rho-like GTP-binding protein 4) c220714.graph_c0 4.1 At2g23150 ATNRAMP3(manganese ion transporter) c140176.graph_c0 3.9 At2g18480 PLT3 (probable polyol transporter 3) c211750.graph_c1 5.9 c204065.graph_c0 6.6 c203825.graph_c0 6.2 At3g05400 SUGTL5 (sugar transporter ERD6-like 12) c207258.graph_c2 3.5 c155119.graph_c1 3.3 At3g12750 ZIP (zinc transporter 1) c183609.graph_c0 4.2 c217013.graph_c0 3.8...”
- The Vitis vinifera sugar transporter gene family: phylogenetic overview and macroarray expression profiling
Afoufa-Bastien, BMC plant biology 2010 - “...(AtINT2), At2g35740 (AtINT3), At4g16480 (AtINT4), At3g03090 (AtVGT1), At5g17010 (AtVGT2), At5g59250 (AtVGT3), At2g16120 (AtPMT1), At2g16130 (AtPMT2), At2g18480 (AtPMT3), At2g20780 (AtPMT4), At3g18830 (AtPMT5), At4g36670 (AtPMT6); for Vitis ones see Additional file 1 . Vitis ORFs names were simplified, Vv indicating GSVIVT000. Vitis vinifera putative Polyol/Monosaccharide Transporters (VvPMT; subfamily...”
LOC4349512 D-xylose-proton symporter-like 2 from Oryza sativa Japonica Group
35% identity, 86% coverage
Npun_R5323 sugar transporter from Nostoc punctiforme
33% identity, 94% coverage
BT_0794 D-xylose transporter XylE from Bacteroides thetaiotaomicron VPI-5482
BT0794 D-xylose-proton symporter (D-xylose transporter) from Bacteroides thetaiotaomicron VPI-5482
34% identity, 90% coverage
- An expanded transcriptome atlas for Bacteroides thetaiotaomicron reveals a small RNA that modulates tetracycline sensitivity
Ryan, Nature microbiology 2024 - “...indicated. i , Xylose vs. glucose. Genes belonging to the xylose utilization operon BT_0791 - BT_0794 (Ref. 13 ) are indicated. j , Maltose vs. glucose. Genes belonging to the starch utilization system ( sus ) operon BT_3704 - BT_3698 (Refs. 72 , 73 ) are...”
- Functional genetics of human gut commensal Bacteroides thetaiotaomicron reveals metabolic requirements for growth across environments
Liu, Cell reports 2021 - “...most amino acids. Genes from the xylose utilization pathway (BT0792, xylulose kinase; BT0793, xylose isomerase; BT0794, xylose transporter) were important for growth on xylose only ( Figure 1B ). This example illustrates the biological consistency of fitness assays using our mutant library. To create a gene-phenotype...”
- A Master Regulator of Bacteroides thetaiotaomicron Gut Colonization Controls Carbohydrate Utilization and an Alternative Protein Synthesis Factor
Townsend, mBio 2020 - “...glucuronate utilization genes ( BT1434 to BT1432 ) (D), xylose utilization genes ( BT0791 to BT0794 ) (E), the alanine dehydrogenase gene ( BT1554 ) (F), rnfABCDEF (G), and fusA2 ( BT2167 ) (H). Black represents the input DNA, and red represents the immunoprecipitated DNA. Data...”
- “...(arabinose utilization), BT1272 to BT1277 (fucose utilization), BT1434 to BT1432 (glucuronate utilization), and BT0791 to BT0794 (xylose utilization), as well as BT2818 to BT2825 , BT0453 to BT0449 , BT0439 to BT0443 , and BT4299 to BT4295 , which are predicted to mediate polysaccharide utilization (...”
Q9LLE0 Hexose transporter (Fragment) from Solanum tuberosum
36% identity, 91% coverage
- Comparative Membrane-Associated Proteomics of Three Different Immune Reactions in Potato
Burra, International journal of molecular sciences 2018 - “...Q43775 Glycolate oxidase (EC 1.1.3.15) 1.01 0.18 0.67 PGSC0003DMP400009092 Glyoxisomal malate dehydrogenase 1.65 1.01 1.34 Q9LLE0 Hexose transporter 0.7 0.15 0.24 PGSC0003DMP400035078 Hydrolase, acting on ester bonds 1.91 2.36 2.58 B2D2G3 Hydroxypyruvate reductase (EC 1.1.1.81) 1.25 0.55 0.88 B9JNE9 Insertion sequence transposase protein 2.02 2.43 2.78...”
XylE / b4031 D-xylose:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 7 papers)
xylE / P0AGF4 D-xylose:H+ symporter from Escherichia coli (strain K12) (see 8 papers)
XYLE_ECOLI / P0AGF4 D-xylose-proton symporter; D-xylose transporter from Escherichia coli (strain K12) (see paper)
TC 2.A.1.1.3 / P0AGF4 Xylose (xylopyranose):H+ symporter of 491 aas and 12 TMSs from Escherichia coli (see 7 papers)
xylE D-xylose-proton symporter from Escherichia coli K12 (see 7 papers)
NP_418455 D-xylose:H(+) symporter from Escherichia coli str. K-12 substr. MG1655
b4031 D-xylose transporter from Escherichia coli str. K-12 substr. MG1655
EcolC_3998 sugar transporter from Escherichia coli C str. ATCC 8739
34% identity, 89% coverage
- function: Uptake of D-xylose across the boundary membrane with the concomitant transport of protons into the cell (symport system). Glucose is not transported, but can compete for xylose binding sites and can inhibit xylose transport (in vitro).
catalytic activity: D-xylose(in) + H(+)(in) = D-xylose(out) + H(+)(out) (RHEA:28959) - substrates: H+, Xylose
tcdb comment: Also transports and binds D-glucose and 6-bromo-6-deoxy-D-glucose. The 3-d structure is known in three conformers, outward occluded, inward occluded and inward open (Sun et al. 2012: Quistgaard et al. 2013). Most of the sugar-binding residues are conserved with the human Glut-1, 2, 3 and 4 homologues. The coalescence of intramolecular tunnels and cavities has been postulated to account for facilitated diffusion of sugars Quistgaard et al. 2013). Most of the sugar-binding residues are conserved with the human Glut-1, 2, 3 and 4 homologues. The coalescence of intramolecular tunnels and cavities has been postulated to account for facilitated diffusion of sugars (Cunningham and Naftalin 2014) - Hydrogen-deuterium exchange mass spectrometry captures distinct dynamics upon substrate and inhibitor binding to a transporter.
Jia, Nature communications 2020 - GeneRIF: Hydrogen-deuterium exchange mass spectrometry captures distinct dynamics upon substrate and inhibitor binding to a transporter.
- Molecular determinants for the thermodynamic and functional divergence of uniporter GLUT1 and proton symporter XylE.
Ke, PLoS computational biology 2017 - GeneRIF: The models and subsequent experimental validation suggest that multiple residue substitutions are required to produce the thermodynamic and functional distinction between XylE and GLUT1. Despite the lack of simulation studies with substrates, these computational and biochemical characterizations provide unprecedented insight into the mechanistic difference between proton symporters and uniporters.
- Affinity and path of binding xylopyranose unto E. coli xylose permease.
Wambo, Biochemical and biophysical research communications 2017 - GeneRIF: Molecular dynamics (MD) study of an all-atom model system to elucidate the atomistic details and the free-energy landscape along the path of binding a xylopyranose from the extracellular space to the inside of the transporter protein XylE. From the MD simulations, the Gibbs free energy of binding was found to be -4.4kcal/mol in agreement with the experimental value of -4.7kcal/mol.
- pH Regulation of Electrogenic Sugar/H+ Symport in MFS Sugar Permeases.
Bazzone, PloS one 2016 - GeneRIF: studies suggest that a single carboxyl group in LacY (Glu325) may be the only side chain directly involved in H+ translocation and a carboxyl side chain with similar properties has been identified in FucP (Asp46) and XylE (Asp27), the present results imply that the pK of this residue is switched during H+/sugar symport in all three symporters.
- Conserved movement of TMS11 between occluded conformations of LacY and XylE of the major facilitator superfamily suggests a similar hinge-like mechanism.
Västermark, Proteins 2015 - GeneRIF: Studied conformational states and homology of LacY and XylE.
- Proton-coupled sugar transport in the prototypical major facilitator superfamily protein XylE.
Wisedchaisri, Nature communications 2014 - GeneRIF: The movement of XylE is described that facilitates sugar translocation across a lipid membrane and identify the likely candidate proton-coupling residues as the conserved Asp27 and Arg133.
- Reptation-induced coalescence of tunnels and cavities in Escherichia Coli XylE transporter conformers accounts for facilitated diffusion.
Cunningham, The Journal of membrane biology 2014 - GeneRIF: This current model helps to unify the apparently opposing concepts of alternate access and multisite models of ligand transport.
- High-level intracellular expression of heterologous proteins in Brevibacillus choshinensis SP3 under the control of a xylose inducible promoter
D'Urzo, Microbial cell factories 2013 - “...the Brevibacillus brevis NBRC 100599 genome. The BLAST search using the E. coli XylE (GenBank: NP_418455) as input could only identify an alpha-ketoglutarate permease (YP_002770906) with low sequence identity with E. coli XylE (20% identity) and B. megaterium XylT (18,5% identity). The BLAST search using E....”
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- Utilization of AlphaFold2 to Predict MFS Protein Conformations after Selective Mutation
Xiao, International journal of molecular sciences 2022 - “...from Prediction and Experiment To date, several structures of MFS proteins (UniProt ID: P0AA76, P0AEY8, P0AGF4, P02920, Q6MLJ0, and Q9LT15) have been found in both the outward- and inward-opening conformations [ 9 , 10 , 11 , 12 , 30 , 31 , 32 , 33...”
- “...6E9O) for P0AA76, 1.01 (inward, PDB ID: 4QIQ) and 0.42 (outward, PDB ID: 4GBY) for P0AGF4, 1.12 (inward, PDB ID: 1PV6) and 0.56 (outward, PDB ID: 5GXB) for P02920, 0.71 (inward, PDB ID: 5AYO) and 0.83 (outward, PDB ID: 5AYM) for Q6MLJ0, 0.88 (inward, PDB ID:...”
- Evolutionary balance between foldability and functionality of a glucose transporter
Choi, Nature chemical biology 2022 - “...sapiens Solute carrier family 2 facilitated glucose transporter member 3 (P11169), Escherichia coli D-xylose-proton symporter (P0AGF4), Plasmodium falciparum Hexose transporter 1 (O97467), Staphylococcus epidermidis Glucose transporter (A0A0H2VG78) and Arabidopsis thaliana Sugar transport protein 10 (Q9LT15). The PDB accession number for structures for these reference proteins are...”
- “...4ZWC, 4ZW9, 4GBZ, 6RW3, 4LDS and 6H7D). Also, The following UniProt IDs were used (P11169, P0AGF4, O97467, A0A0H2VG78 and Q9LT15). Code availability A program, written in LabView, to control the magnetic tweezers apparatus has been deposited in Github ( https://github.com/tyyoonlab/Science_aaw8208 ) and is available at Zenodo...”
- Contribution of Stenotrophomonas maltophilia MfsC transporter to protection against diamide and the regulation of its expression by the diamide responsive repressor DitR
Boonyakanog, PloS one 2022 - “...LacY (P02920), LmrP (Q48658), MdfA (P0AEY8), MdtG (P25744), MhpT (P77589), NorA (P0A0J7), TetA (P02981), XylE (P0AGF4), YicM (J7R7Q1). mfsC mutant is susceptible to diamide To evaluate the physiological function of mfsB and mfsC in S . maltophilia , the mfsB and mfsC mutants were constructed and...”
- Structural comparison of GLUT1 to GLUT3 reveal transport regulation mechanism in sugar porter family.
Custódio, Life science alliance 2021 - “...), rGLUT5 (UniProt P43427 ), bGLUT5 (UniProt P58353 ), atSTP10 (UniProt Q9LT15 ), XylE (UniProt P0AGF4 ), and GlcPse (UniProt A0A0H2VG78 ). Conserved residues are highlighted with gray-scale. Alpha helices as found in GLUT1 are represented above the sequence as colored tubes. Residues highlighted in blue...”
- “...of the GLUT1 bacterial homolog. Sequence alignment between GLUT3 (UniProt P11169 ) and XylE (UniProt P0AGF4 ) of the C-domain A motif and the C-domain SP motif. Conserved residues are highlighted in bold. The residues belonging to the A motif and the SP motif are colored...”
- Proton-solute coupling mechanism of the maltose transporter from Saccharomyces cerevisiae
Henderson, Scientific reports 2017 - “...46 . Transporter sequences were found with the following UniProt accession numbers: Mal11 (P54038), XylE (P0AGF4), LacY (P02920), MelB (P02921), GLUT1 (P11166), GLUT3 (P11169). Mal11 structural modeling De novo structure prediction using evolutionary co-variation of residue pairs was performed with the EVfold server 16 , 17...”
- A Numbering System for MFS Transporter Proteins.
Lee, Frontiers in molecular biosciences 2016 - “...Into cell Arabidopsis thaliana NarU NNP P37758 Nitrate/nitrite symport Into cell E. coli XylE SP P0AGF4 Xylose/H + symport Into cell E. coli MelB Glycoside-pentoside-hexuronide: cation symporter P30878 Melibose/Na + symport Into cell Salmonella typhimurium The cluster containing each protein sequence in UniRef50 was downloaded and...”
- Proton-coupled sugar transport in the prototypical major facilitator superfamily protein XylE
Wisedchaisri, Nature communications 2014 - “...list of homologues are as follows with Uniprot accession number in parentheses: Escherichia coli XylE (P0AGF4); Lactobacillus brevis D -xylose/H + symporter XylT (O52733); Escherichia coli galactose permease GalP (P0AEP1); Escherichia coli arabinose permease AraE (P0AE24); Bacillus subtilis myo-inositol/H + transporter IolT (O34718); Arabidopsis thaliana inositol/H...”
- Reptation-induced coalescence of tunnels and cavities in Escherichia Coli XylE transporter conformers accounts for facilitated diffusion
Cunningham, The Journal of membrane biology 2014 - “...conformer structures3a, 3b, 4a, 4b and 4c, the chains were restructured using the UniProt sequence P0AGF4 (XylE_ECOLI) in SwissModel Automatic Modelling Mode at http://swissmodel.expasy.org . These newer structures were superimposable on the originals and did not alter any of the docking positions or assigned affinities of...”
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- About the dark corners in the gene function space of Escherichia coli remaining without illumination by scientific literature
Tantoso, Biology direct 2023 - “...( arsR /GF_510), b3531 ( bcsZ /GF_9943), b3717 ( cbrC /GF_3491), b4011 ( yjaA /GF_20677), b4031 ( xylE /GF_10135), b4348 ( hsdS /GF_3705), and b4351 ( mrr /GF_10255). Similarly, 32 intensively studied GFs from the softcore genome do not contain an E. coli K-12 MG1655 homologue:...”
- Generation and Characterization of Acid Tolerant Fibrobacter succinogenes S85
Wu, Scientific reports 2017 - “...(b3685) 3 2230314 Fisuc_1804 xylE sugar transporter 205 C T 217 220 96.14 Ala69Thr JW3991 (b4031) 4 2399135 Fisuc_1945 rlmM ( ygdE ) DNA alkylation repair + 331 A G 199 199 94.12 Thr111Ala JW2777 (b2806) 5 2561445 Fisuc_2074 mscL Large conductance mechanosensitive channel protein. Critical...”
- Combined, functional genomic-biochemical approach to intermediary metabolism: interaction of acivicin, a glutamine amidotransferase inhibitor, with Escherichia coli K-12
Smulski, Journal of bacteriology 2001 - “...b0998 b3519 b1421 b1610 b3453 b1183 b3495 b1521 b0422 b4031 b2605 b3073 b3103 b3877 b0058 b0105 b0119 b0163 b0233 b0286 b0288 Fold induction 2.1 4.7 4.3 2.8...”
- A novel point mutation in RpoB improves osmotolerance and succinic acid production in Escherichia coli
Xiao, BMC biotechnology 2017 - “...(EcolC_1645, EcolC_1646, and EcolC_1647), mannose PTS (ManY: EcolC_1814 and ManZ: EcolC_1813), D-xylose proton symporter XylE (EcolC_3998), and the melibiose-sodium co-transport system (EcolC_3907) were decreased 2- to 5- fold in Suc-T110 when compared to the corresponding levels in RpoBD645Y. These data demonstrated that repression effects on sugar...”
TC 2.A.1.1.122 / AGG19156.1 Sorbitol (glucitol):H+ co-transporter, SOT2 (Km for sorbitol of 0.81 mM) of 491 aas and 12 TMSs (Gao et al. 2003). SOT2 of Prunus cerasus is mainly expressed only early in fruit development and not in leaves from Pyrus pyrifolia
34% identity, 90% coverage
Fisuc_1804 sugar transporter from Fibrobacter succinogenes subsp. succinogenes S85
33% identity, 92% coverage
- Generation and Characterization of Acid Tolerant Fibrobacter succinogenes S85
Wu, Scientific reports 2017 - “...six variations are single nucleotide substitutions, resulting in six residue changes in five genes, Fisuc_0527, Fisuc_1804, Fisuc_1945, Fisuc_2074 and Fisuc_2957, encoding SufD, XylE, RlmM, MscL and DosC, respectively. Table 2 Sequence variations between the acid tolerant strain and wild type of F . succinogenes S85. Number...”
- “...100 Frameshift. Stop codon at the 18th codon after the shift. JW3662 (b3685) 3 2230314 Fisuc_1804 xylE sugar transporter 205 C T 217 220 96.14 Ala69Thr JW3991 (b4031) 4 2399135 Fisuc_1945 rlmM ( ygdE ) DNA alkylation repair + 331 A G 199 199 94.12 Thr111Ala...”
- Evaluating Models of Cellulose Degradation by Fibrobacter succinogenes S85
Burnet, PloS one 2015 - “...and III secretion systems had higher expression in the cellulose compared to the glucose cultures. Fisuc_1804, an annotated sugar transporter, was found to have higher expression in the cellulose cultures, relative to glucose ( Fig 3 ). 10.1371/journal.pone.0143809.g001 Fig 1 Expression of fibro-slime genes in F...”
FTN_1079 sugar porter (SP) family from Francisella tularensis subsp. novicida U112
35% identity, 94% coverage
- Genotype-phenotype associations in a nonmodel prokaryote
Enstrom, mBio 2012 - “...Three additional gene functions were needed for growth on N -acetylglucosamine: a predicted sugar porter, FTN_1079 (here named nagP ), glucokinase ( glk ), and a putative transaminase, FTN_1080 ( nagB ). The FTN_1080 ( nagB ) product was annotated as a phosphosugar-binding protein and appears...”
plt1 / CAD58709.1 polyol transporter from Plantago major (see paper)
31% identity, 86% coverage
EcolC_0874 sugar transporter from Escherichia coli C str. ATCC 8739
34% identity, 93% coverage
- New xylose transporters support the simultaneous consumption of glucose and xylose in <i>Escherichia coli</i>
Zhu, mLife 2022 - “...ATG (full length of 2574bp) Mutations in strain AE2.0 EcolC_0872 kduI Hexanoate isomerase G93C (G277T) EcolC_0874 araE Arabinoseproton symporter D223Y (G667T) EcolC_0878 galR Transcriptional regulator 72 bp/coding (2394/1032 nt) EcolC_3593 araC Transcriptional regulator, AraC family L156I (C466A) PTS, phosphotransferase system. John Wiley & Sons, Ltd. Characterization...”
- “...Product Relative expression level in AE2.0 versus PS2.0 Relative expression level in REV2.0 versus PS2.0 EcolC_0874 araE Arabinoseproton symporter 58 42 EcolC_1734 araF Larabinosebinding periplasmic protein 2.3 2 EcolC_1735 araG Arabinose import ATPbinding protein 9 4.8 EcolC_1736 araH Arabinose ABC transporter permease 3.9 3.5 EcolC_3593 araC...”
AraE / b2841 arabinose:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 5 papers)
araE / P0AE24 arabinose:H+ symporter from Escherichia coli (strain K12) (see 5 papers)
ARAE_ECOLI / P0AE24 Arabinose-proton symporter; Arabinose transporter from Escherichia coli (strain K12) (see 4 papers)
TC 2.A.1.1.2 / P0AE24 Arabinose (xylose; galactose):H+ symporter, AraE (low affinity high capacity) from Escherichia coli (see 6 papers)
b2841 arabinose transporter from Escherichia coli str. K-12 substr. MG1655
34% identity, 93% coverage
- function: Uptake of L-arabinose across the cytoplasmic membrane with the concomitant transport of protons into the cell (symport system) (PubMed:2836407, PubMed:6282256, PubMed:7030324). D-fucose, a nonmetabolizable analog of L-arabinose, is also a good substrate (PubMed:6282256).
catalytic activity: H(+)(in) + L-arabinose(in) = H(+)(out) + L-arabinose(out) (RHEA:28951)
catalytic activity: D-fucose(in) + H(+)(in) = D-fucose(out) + H(+)(out) (RHEA:35011) - substrates: Arabinose, D-galactose, D-xylose, L-arabinose
- CyuR is a dual regulator for L-cysteine dependent antimicrobial resistance in Escherichia coli
Rodionova, Communications biology 2024 - “...- 2.4 17 raiA b2597 Ribosome-associated inhibitor A 89 4.89 GAcaAAATTaTgAgAtTTTcaTC 2.2 4.0 18 araE b2841 Arabinose symporter 5 4.7 GAAaAAATgGTTACtATcaATaC - 1.6 19 yhiJ b3488 DUF4049 protein 49 4.97 GAtaAAATgtTAACtATgTATTC - 3.4 20 aldB b3588 Aldehyde dehydrogenase 199 5.61 GAAgAAATTGTgGCgATTTATCg 1.2 - 21 pfkA b3916...”
- The asymptomatic bacteriuria Escherichia coli strain 83972 outcompetes uropathogenic E. coli strains in human urine
Roos, Infection and immunity 2006 - “...b0063 c3624 b1498 b0593 b1616 b2737 c1599 b2841 b2736 c3623 b4451 c1250 b2704 c4310 Hypothetical protein Putative glucosyltransferase Ferric enterobactin...”
- Contribution of Stenotrophomonas maltophilia MfsC transporter to protection against diamide and the regulation of its expression by the diamide responsive repressor DitR
Boonyakanog, PloS one 2022 - “...(B2FTN0), Mmr (P11545), Pur8 (P42670), QacA (Q1XG09), QacB (Q7WUJ5), SmvA (P37594), VceB (O51919). DHA12; AraE (P0AE24), Bcr (P28246), Blt (P39843), Bmr (P33449), CmlA (Q83V15), EmrD (P31442), EmrD-3 (C3LUT7), GalP (P0AEP1), LacY (P02920), LmrP (Q48658), MdfA (P0AEY8), MdtG (P25744), MhpT (P77589), NorA (P0A0J7), TetA (P02981), XylE (P0AGF4),...”
- Proton-coupled sugar transport in the prototypical major facilitator superfamily protein XylE
Wisedchaisri, Nature communications 2014 - “...+ symporter XylT (O52733); Escherichia coli galactose permease GalP (P0AEP1); Escherichia coli arabinose permease AraE (P0AE24); Bacillus subtilis myo-inositol/H + transporter IolT (O34718); Arabidopsis thaliana inositol/H + symporter INT1 (Q8VZR6); Arabidopsis thaliana hexose/H + symporter STP1 (P23586); Parachlorella kessleri hexose/H + symporter HUP1 (P15686); Homo sapiens...”
DR76_1762 arabinose-proton symporter AraE from Escherichia coli ATCC 25922
34% identity, 93% coverage
- Chemogenomic Screen for Imipenem Resistance in Gram-Negative Bacteria
El, mSystems 2019 - “...Rnf DR76_3209 (2) DR88_4075 (2) rnfC G COG2814 Predicted arabinose efflux permease DR76_1590 (2) nanT DR76_1762 (2) DR76_4561 (2) araJ DR88_690 (3) J COG0445 tRNA U34 5-carboxymethylaminomethy modifying enzyme MnmG/GidA DR76_727 (4) DR88_3339 (2) gidA COG0215 Cysteinyl-tRNA synthetase DR76_4436 (2) DR88_4524 (3) cysS L COG0847 DNA...”
S3049 low-affinity L-arabinose transport system proton symport protein from Shigella flexneri 2a str. 2457T
34% identity, 93% coverage
TC 2.A.1.1.79 / Q1XF07 Polyol (xylitol):H+ symporter, PLT4 from Lotus japonicus
31% identity, 88% coverage
CCNA_00857 D-xylose transporter from Caulobacter crescentus NA1000
32% identity, 92% coverage
- mutant phenotype: Specifically important for D-xylose utilization. Also see PMC2168598 and PMC344409. May also be important for lactose utilization, which is not explained.
CC0814 major facilitator family transporter from Caulobacter crescentus CB15
32% identity, 84% coverage
- Regulation of D-xylose metabolism in Caulobacter crescentus by a LacI-type repressor
Stephens, Journal of bacteriology 2007 - “...on the top line. This region includes xylE (CC0814), which encodes a putative xylose transporter. The gene nomenclature is the nomenclature described previously...”
- “...of other members of this regulon, we examined expression of CC0814, which is located near the xyl operon but is not part of the same transcription unit (Fig....”
- Transcriptional profiling of Caulobacter crescentus during growth on complex and minimal media
Hottes, Journal of bacteriology 2004 - “...fbaA Transport CC0442, TonB-dependent receptora CC0814, major facilitator family transporterc CC0991, TonB-dependent receptora CC0999, TonB-dependent receptor,...”
- “...membrane. Xylose also induced expression of a gene (CC0814) encoding a member of the major facilitator superfamily of inner membrane proteins. The CC0814...”
XP_001387138 sugar transporter, putative from Scheffersomyces stipitis CBS 6054
A3GHU5 Sugar transporter, putative from Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)
35% identity, 80% coverage
- Genetic basis of the highly efficient yeast Kluyveromyces marxianus: complete genome sequence and transcriptome analyses
Lertwattanasakul, Biotechnology for biofuels 2015 - “...Ci_GXF1, GN107179; Ps_SUT1, XP_001387898; Ps_SUT2, XP_001384295; Ps_SUT3, XP_001386019; Ps_HXT2.4, XP_001387757; Ps_XUT1, XP_001385583; Ps_XUT2, XP_001387242; Ps_XUT3, XP_001387138; Ps_XUT4, XP_001386715; Ps_XUT5, XP_001385962; Ps_XUT6, XP_001386589; Ps_XUT7, XP_001387067; Ps_RGT2, XP_001386588; Ps_SLT1, XP_001383774; Kl_KHT1/RAG1, XP_453656; Kl_KHT2, GN107317; Kl_KHT3, XP_454897; Kl_FRT1, XP_454356; Kl_HGT1, XP_451484; Kl_HXT1, XP_455078; Kl_HXT14, XP_454897; Kl_HXT2, XP_453960; Kl_HXT3, XP_453088;...”
- Functional survey for heterologous sugar transport proteins, using Saccharomyces cerevisiae as a host
Young, Applied and environmental microbiology 2011 - “...XUT6 Q6CFJ6 A3LY79 XUT5 Q6CG30 A3M0B9 XUT4 YALI0B01342 A3GHU5 XUT3 BLAST BLAST BLAST BLAST BLAST NCBI NCBI NCBI; intron-free version synthesized by Blue Heron...”
4gbyA / P0AGF4 The structure of the mfs (major facilitator superfamily) proton:xylose symporter xyle bound to d-xylose (see paper)
34% identity, 89% coverage
- Ligand: beta-d-xylopyranose (4gbyA)
STM4418 sugar (and other) transporter from Salmonella typhimurium LT2
32% identity, 93% coverage
- High binding affinity of repressor IolR avoids costs of untimely induction of myo-inositol utilization by Salmonella Typhimurium
Hellinckx, Scientific reports 2017 - “...dacB ::Kan R Allelic-exchange mutant This study 14028 iolR ::Kan R 44184436 Deletion of iolT1 (STM4418) to iolH (STM4436) in 14028 iolR ::Kan R This study MvP101 14028 with sseD :: aphT , Kan R ; allelic-exchange mutant 37 MvP101 iolR In-frame iolR (STM4417) deletion mutant...”
- Identification of novel factors involved in modulating motility of Salmonella enterica serotype typhimurium
Bogomolnaya, PloS one 2014 - “...1.580.34 STM2897 invE 1.560.30 1.41 0.51 STM3954 yigG 1.360.22 1.19 0.33 STM4212 1.14 0.24 1.470.45 STM4418 1.260.21 1.40 0.68 PSLT013 pefI 0.98 0.19 1.180.11 PSLT098 traQ 1.04 0.22 1.330.23 * - Diameter of swimming and swarming rings were measured and compared to wild type. Results are...”
- myo-Inositol transport by Salmonella enterica serovar Typhimurium
Kröger, Microbiology (Reading, England) 2010 (PubMed)- “...MI transporters of this pathogen. In-frame deletion of iolT1 (STM4418) led to a severe growth defect, and deletion of iolT1 (STM4419) to a slight growth defect...”
- “...of them (Kroger & Fuchs, 2009). Four genes, STM4418, STM4419, STM4428 and STM4434, encode putative, as yet uncharacterized, permeases. Their role in MI...”
- Genomic comparison of Salmonella enterica serovars and Salmonella bongori by use of an S. enterica serovar typhimurium DNA microarray
Chan, Journal of bacteriology 2003 - “...present in serovar Typhimurium. The region from STM4418 to STM4436 includes sugar transporters, putative endonucleases, and putative cytoplasmic proteins that...”
FTN_0687 galactose-proton symporter, major facilitator superfamily (MFS) transport protein from Francisella tularensis subsp. novicida U112
34% identity, 93% coverage
- Structural and functional analysis of the Francisella lysine decarboxylase as a key actor in oxidative stress resistance
Felix, Scientific reports 2021 - “...A 0.926959218 6.24086E07 FTN_1697 Galactose mutarotase 0.901042767 0.008192095 FTN_1148 Glycoprotease family protein 0.816650922 0.005012835 galP1 FTN_0687 Major facilitator superfamily galactose-proton symporter 0.746905316 5.94864E05 FTN_1459 Short chain dehydrogenase 0.723695755 0.001285646 FTN_1254 Hypothetical protein 0.716291799 0.00237079 FTN_1266 ABC transporter membrane protein 0.66256701 0.001562237 FTN_0923 Hypothetical protein 0.654493997 0.002785307...”
- Molecular complexity orchestrates modulation of phagosome biogenesis and escape to the cytosol of macrophages by Francisella tularensis
Asare, Environmental microbiology 2010 - “...tnfn1_pw060323p06q164 FTN_0624 serine permease 2 2 * tnfn1_pw060418p01q161 FTN_0636 glpT glycerol-3-phosphate transporter 7 7 tnfn1_pw060419p04q142 FTN_0687 galP1 galactose-proton symporter, major facilitator superfamily (MFS) transport protein 2 3 * tnfn1_pw060510p04q158 FTN_0687 galP1 galactose-proton symporter, major facilitator superfamily (MFS) transport protein 2 2 * tnfn1_pw060328p06q132 FTN_0728 predicted Co/Zn/Cd...”
- Exploitation of host cell biology and evasion of immunity by francisella tularensis
Asare, Frontiers in microbiology 2010 - “...nicotinamide ribonucleoside (NR) uptake permease (PnuC) family protein FTN_0624 Serine permease FTN_0636 glpT Glycerol-3-phosphate transporter FTN_0687 galP1 Galactose-proton symporter, major facilitator superfamily (MFS) transport protein FTN_0728 Predicted Co/Zn/Cd cation transporter FTN_0739 potG ATP-binding cassette putrescine uptake system, ATP-binding protein FTN_0799 emrE Putative membrane transporter of cations...”
- Molecular bases of proliferation of Francisella tularensis in arthropod vectors
Asare, Environmental microbiology 2010 - “...tnfn1_pw060323p06q164 FTN_0624 serine permease 2 2 * tnfn1_pw060418p01q161 FTN_0636 glpT glycerol-3-phosphate transporter 7 7 tnfn1_pw060419p04q142 FTN_0687 galP1 galactose-proton symporter, major facilitator superfamily (MFS) transport protein 2 3 * tnfn1_pw060510p04q158 FTN_0687 galP1 galactose-proton symporter, major facilitator superfamily (MFS) transport protein 2 2 * tnfn1_pw060328p06q132 FTN_0728 predicted Co/Zn/Cd...”
AT5G17010, NP_850835 sugar transporter family protein from Arabidopsis thaliana
Q6AWX0 D-xylose-proton symporter-like 2 from Arabidopsis thaliana
36% identity, 85% coverage
- An atlas of rational genetic engineering strategies for improved xylose metabolism in Saccharomyces cerevisiae
Vargas, PeerJ 2023 - “...XKS1 / hxt1-17 / gal2 Higher affinity for xylose ( Colabardini et al., 2014 ) AT5G17010 ( Arabidopsisthaliana) BY4727 - Scheffersomyces stipitis XYL1 and XYL2 / XKS1 25% and 40% increase in xylose consumption ( Hector et al., 2008 ) AT5G59250 ( Arabidopsisthaliana) AT5G59250 ( Arabidopsis...”
- “...; Dos Reis et al., 2016 ). In Arabidopsis thaliana , genes encoding sugar transporters AT5G17010 and At5g59250 were expressed in recombinant S. cerevisiae containing the genetic modifications for xylose consumption, and the consumption of this pentose was analyzed in fermentations. Strains expressing the AT5G17010 and...”
- Responsiveness of Early Response to Dehydration Six-Like Transporter Genes to Water Deficit in Arabidopsis thaliana Leaves
Slawinski, Frontiers in plant science 2021 - “...other vacuolar SUTs: AtSWEET16 (At3g16690), AtSWEET17 (At4g15920), AtTMT1 (At1g20840), AtTMT2 (At4g35300), AtSUC4 (At1g09960), and AtVGT2 (At5g17010), and of vacuolar invertases At Fruct3 (At1g62660) and Atfruct4 (At1g12240) were performed using the rosette leaves of Col-0 and mutant plants grown in WW, WD, and RW conditions. Quantitative PCR...”
- Valorisation of xylose to renewable fuels and chemicals, an essential step in augmenting the commercial viability of lignocellulosic biorefineries
Narisetty, Sustainable energy & fuels 2021 - “...was enhanced by 25 and 40% with the introduction of Arabidopsis thaliana xylose transporter genes At5g17010 and At5g59250 , respectively. 192 A large improvement (75%) in xylose transport was achieved with Gxf1 , a MFS transporter identified from Candida intermedia . 193 This traditional xylose transporter...”
- Valorisation of pectin-rich agro-industrial residues by yeasts: potential and challenges
Martins, Applied microbiology and biotechnology 2020 - “...for sugar transporters are not many, but the heterologous integration of the xylose transporter gene AT5G17010 from A. thaliana into C. tropicalis resulted in a 3773% increase in xylose uptake compared to the original strain (Jeon et al. 2013 ). Given that synthetic biology methods and...”
- Novel xylose transporter Cs4130 expands the sugar uptake repertoire in recombinant Saccharomyces cerevisiae strains at high xylose concentrations
Bueno, Biotechnology for biofuels 2020 - “...also able to restore significant xylose growth on expressing strains. Even A. thaliana xylose transporters, At5g17010 and At5g59250, were responsible for 25% and 40% of improvements in xylose consumption rate, respectively, on S. cerevisiae strains [ 57 ]. As highlighted above, the facilitator Gxf1 isolated from...”
- Identification of Cargo for Adaptor Protein (AP) Complexes 3 and 4 by Sucrose Gradient Profiling
Pertl-Obermeyer, Molecular & cellular proteomics : MCP 2016 - “...at1g59870 at2g39010 at4g35100 at5g60660 at4g39080 at5g17010 at1g71880 ap-4 mutant at1g52780 at1g59610 at2g37170 at3g52400 at4g08850 at4g13510 at4g23630...”
- Effect of heterologous xylose transporter expression in Candida tropicalis on xylitol production rate
Jeon, Bioprocess and biosystems engineering 2013 (PubMed)- “...In this study, a heterologous xylose transporter gene (At5g17010) from Arabidopsis thaliana was selected because of its high affinity for xylose and was...”
- “...gene Codon-optimization of the heterologous xylose transporter gene At5g17010 of A. thaliana was performed for Table 1 Candida tropicalis strains used in this...”
- Expression patterns of genes involved in sugar metabolism and accumulation during apple fruit development
Li, PloS one 2012 - “...Figure 2I ). Both MdvGT1 and MdvGT2 had high homology with AtvGT1 (At3g03090) and AtvGT2 (At5g17010), respectively, and were in the same clade, whereas they had low similarity with AtvGT3 (At5g59250) ( Figure 2J ). Expression of genes in source and sink tissues To determine tissue-specific...”
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- The phosphoproteome in regenerating protoplasts from Physcomitrella patens protonemata shows changes paralleling postembryonic development in higher plants
Wang, Journal of experimental botany 2014 - “...APE2 (ACCLIMATION OF PHOTOSYNTHESIS TO ENVIRONMENT 2); antiporter/triose-phosphate transmembrane transporter Chloroplast QFS#TAS#SSSFS#VK C65 53.5 6.36 Q6AWX0 d -xylose-proton symporter-like 2 Membrane M*ALDPEQQQPISSVS#R C66 25.6 5.24 Q9SP35 Mitochondrial import inner membrane translocase subunit Tim17 Membrane EDPWNS#IIAGAATGGFLSMR C67 84.6 9.29 Q9S9N5 Putative cyclic nucleotide-gated ion channel 7 Membrane...”
- Functional survey for heterologous sugar transport proteins, using Saccharomyces cerevisiae as a host
Young, Applied and environmental microbiology 2011 - “...DEHA2B14278 xylE Q6BTD8 Q2MEV7 GXS1 DEHA0D02167 Q2MDH1 Q6AWX0 At5g17010 GXF1 Q0WWW9 P22144 At5g59250 P31867 XYL2 UniProt accession no. XYL1 Gene/locus tag...”
- Optimizing pentose utilization in yeast: the need for novel tools and approaches
Young, Biotechnology for biofuels 2010 - “...TMB3201 - Arabidopsis thaliana At5g59250 Q0WWW9 pRH145 [ 75 ] BY4727 + Arabidopsis thaliana At5g17010 Q6AWX0 pRH145 [ 75 ] BY4727 + Arabidopsis thaliana Seedling cDNA [ 104 ] - pFL61 [ 64 ] TMB3201 - Candida intermedia Gxf1 Q2MDH1 YEplac195 [ 72 ] TMB3201 +...”
PLT5_ARATH / Q8VZ80 Polyol transporter 5; Protein POLYOL TRANSPORTER 5; AtPLT5; Sugar-proton symporter PLT5 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
TC 2.A.1.1.34 / Q8VZ80 The broad specificity sugar/sugar alcohol (myo-inositol, glycerol, ribose, sorbitol, mannitol, xylitol, erythritol, etc) H+ symporter, AtPLT5 (transports a wide range of hexoses, pentoses, tetroses, sugar alcohols and a sugar acid, but not disaccharides) (Reinders et al., 2005) (expressed in roots, leaves and floral organs) from Arabidopsis thaliana (Mouse-ear cress) (see 5 papers)
PLT5 / RF|NP_188513.1 polyol transporter 5 from Arabidopsis thaliana (see paper)
NP_188513 polyol/monosaccharide transporter 5 from Arabidopsis thaliana
AT3G18830 ATPLT5 (POLYOL TRANSPORTER 5); D-ribose transmembrane transporter/ D-xylose transmembrane transporter/ carbohydrate transmembrane transporter/ galactose transmembrane transporter/ glucose transmembrane transporter/ glycerol transmembrane transporter/ mannitol transmembrane transporter/ monosaccharide transmembrane transporter/ myo-inositol transmembrane transporter/ sorbitol transmembrane transporter/ sugar:hydrogen symporter from Arabidopsis thaliana
31% identity, 84% coverage
- function: Plasma membrane broad-spectrum sugar-proton symporter. Mediates the uptake of linear polyols such as sorbitol, xylitol, erythritol or glycerol. Can transport the cyclic polyol myo-inositol and different hexoses, pentoses (including ribose), tetroses and sugar alcohols.
- substrates: Erythritol, H+, Ribose, Sorbitol, Xylitol, glycerol, mannitol, myo-inositol
- Analysis of transport activity of Arabidopsis sugar alcohol permease homolog AtPLT5.
Reinders, The Journal of biological chemistry 2005 (PubMed)- GeneRIF: Analysis of transport properties and expression in Arabidopsis indicate that AtPLT5 functions to transport a wide range of sugars into specific sink tissues in the plant [PLT5]
- Arabidopsis POLYOL TRANSPORTER5, a new member of the monosaccharide transporter-like superfamily, mediates H+-Symport of numerous substrates, including myo-inositol, glycerol, and ribose.
Klepek, The Plant cell 2005 - GeneRIF: AtPLT5 is a broad-spectrum H-symporter for linear polyols, such as sorbitol, xylitol, erythritol, or glycerol. It also catalyzes the transport of the cyclic polyol myo-inositol and of different hexoses and pentoses, including ribose[AtPLT5]
- Transcriptome analysis to identify candidate genes associated with the yellow-leaf phenotype of a Cymbidium mutant generated by γ-irradiation
Kim, PloS one 2020 - “...Copper transport protein CCH 2.84536 0.009691 TRINITY_DN82149_c4_g1 Q94LW6 SUT35 Sulfate transporter 3;5 1.33172 0.018302 TRINITY_DN86390_c5_g1 Q8VZ80 PLT5 Polyol transporter 1.74481 0.010401 TRINITY_DN81484_c2_g1 Q93ZF5 PHO11 Phosphate transporter PHO1 homolog 1 11.8706 1.8 10 17 TRINITY_DN82844_c0_g1 Q9C9Z1 ZTP50 Zinc transporter 50 1.51218 8.95 10 5 TRINITY_DN85192_c3_g1 Q9M1P7 BOR2...”
- Automated identification of reference genes based on RNA-seq data
Carmona, Biomedical engineering online 2017 - “...Q94A41 Alpha-amylase 3, chloroplastic Arabidopsis thaliana rp11_olive_006061 327 272 238 343 285 253 13.16 286.3 Q8VZ80 Polyol transporter 5 Arabidopsis thaliana rp11_olive_006091 283 221 211 208 177 190 15.65 215 A0A022R151 Uncharacterized protein Erythranthe guttata rp11_olive_010107 228 213 184 250 295 199 15.98 228.2 O23254 Serine...”
- Silencing of a mannitol transport gene in Phelipanche aegyptiaca by the tobacco rattle virus system reduces the parasite germination on the host root
Bari, Plant signaling & behavior 2022 - “...for cloning in pTRV2 Best Arabidopsis Hit >OrAe2FB1_3281: Length (2049 nt) Mannitol transporter (PaMNT1) 275bp AT3G18830 >OrAe2FB1_29: Length (2791 nt) Methionine synthase (PaMET1) 231bp AT3G03780 >OrAe2FB1_910: Length (1892 nt) Sucrose transporter (PaSUT1) 268bp AT1G22710 >OrAe42GB1_49526: Length (2821 nt) Ubiquitin protein ligase (PaUBQ3) 213bp AT5G05560 >OrAe3GB1_10228: Length...”
- Molecular mechanisms of resistance to Myzus persicae conferred by the peach Rm2 gene: A multi-omics view
Le, Frontiers in plant science 2022 - “...shock 70 kDa protein 4 Polyols Prupe_2G288800 AT5G51970 81 yes 1.6 1.40E-02 Sorbitol dehydrogenase Prupe_8G101500 AT3G18830 65 No 2.3 3.30E-05 PLT5; Polyol transporter 5 Glyoxylate metabolism Prupe_4G258800 AT2G13360 86 Yes 2.2 5.60E-06 AGT1; Glyoxylate aminotransferase 1 Prupe_4G082600 AT3G14420 88 No 2.9 3.40E-20 GOX1; Glycolate oxidase Prupe_3G048100...”
- Genomic Regions Associated With Seed Meal Quality Traits in Brassica napus Germplasm
Bhinder, Frontiers in plant science 2022 - “...ISPF SNC_027765.2_8996403 8996403 49451 AT1G63970 A09 3.00 MEP Pathway Phytic acid PMT5 SNC_027757.2_27740015 27740015 39548 AT3G18830 A01 3.30 Myo-inositol transport PLDALPHA1 SNC_027761.2_26966958 26966958 28955 AT3G15730 A05 3.23 Regulator SAC8 SNC_027762.2_34136832 34136832 15543 AT3G51830 A06 3.35 Phosphoinositides regulator PRAF1 SNC_027763.2_16570114 16570114 17113 AT1G76950 A07 3.12 Phosphatidylinositol binding...”
- Membrane nanodomains and transport functions in plant
Martinière, Plant physiology 2021 - “...Leaves/suspension cell cultures Demir et al., 2013 ; Yoshida et al., 2013 Polyol/monosaccharide transporter (PLT) AT3G18830 (PLT5) Leaves Demir et al., 2013 Tonoplast monosaccharide transporter (TMT) AT4G35300 (TMT2) Suspension cell cultures Yoshida et al., 2013 Vacuolar glucose transporter (VGT) AT3G03090 (VGT1) Suspension cell cultures Yoshida et...”
- Comparative Dynamic Transcriptome Reveals the Delayed Secondary-Cell-Wall Thickening Results in Altered Lint Percentage and Fiber Elongation in a Chromosomal Segment Substitution Line of Cotton (Gossypium hirsutum L.)
Gao, Frontiers in plant science 2021 - “...al., 2008 ). GH_D01G0100 encoded a polyol/cyclitol/monosaccharide-H + -symporter and was homologous to ATPMT5 ( AT3G18830 ), which is involved in plant cell wall modifications (Klepek et al., 2009 ). In addition, four of six differently expressed candidate genes, namely GH_D01G0052, GH_D01G0095, GH_D01G0128 , and GH_D01G0154...”
- Shotgun proteomics of peach fruit reveals major metabolic pathways associated to ripening
Nilo-Poyanco, BMC genomics 2021 - “...Nuclear pore glycoprotein p62 AT2G45000 Sugar Transport Prupe.8G101200 0.998 2 Up_O2 POLYOL TRANSPORTER 5 PePOL5 AT3G18830 Specialized Metabolsim Prupe.5G106300 0.772 1 Up_O2 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase / MECDP-synthase AT1G63970 Prupe.8G032700 0.607 1 Up_O2 Sterol 3-beta-glucosyltransferase AT1G43620 Prupe.3G097700 0.5 1 Up_O2 cinnamoyl-CoA reductase (CCR) AT1G15950 Vacuolar Sorting Prupe.7G171800...”
- Genome-wide identification, expression, and association analysis of the monosaccharide transporter (MST) gene family in peanut (Arachis hypogaea L.)
Wan, 3 Biotech 2020 - “...Influences flowering and seed germination AtPLT5/AtPMT5 (AT3G18830) Effect pollen and young xylem cells AtINT4 (AT4G16480) Regulate arsenic accumulation...”
- Large-Scale Phosphoproteomic Study of Arabidopsis Membrane Proteins Reveals Early Signaling Events in Response to Cold
Kamal, International journal of molecular sciences 2020 - “...* AT1G08930 ERD6 Major facilitator superfamily protein ER,PM Solute transport SLS[+80]IRER S 17 A * AT3G18830 PLT5 polyol/monosaccharide transporter 5 PM Solute transport TVPNPEVEIGS[+80]NKQWKEGDTQSS S 527 D * AT1G20840 TMT1 tonoplast monosaccharide transporter1 V,PM Solute transport LYGTHENQSYLARPVPEQNS[+80]SLGLR S 277 E,A * AT1G20840 TMT1 tonoplast monosaccharide transporter1...”
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TC 2.A.1.1.120 / E1WAV3 Major myo-inositol transporter, IolT1, of 456 aas from Salmonella typhimurium (strain SL1344)
31% identity, 96% coverage
Q84QH3 Putative sorbitol transporter from Prunus cerasus
31% identity, 85% coverage
- Transcriptomic and metabolite analyses of Cabernet Sauvignon grape berry development.
Deluc, BMC genomics 2007 - “...21 2.22 1616083_at CB009608 TC51694 Q9ZR63 Hexose transporter (VvHT1) Transport 2 12.37 1610527_at CA815926 TC52979 Q84QH3 Sorbitol transporter Transport 2 5.49 1615257_at CB972713 TC65400 Q4U339 Hexose transporter (VvHT6) Transport 15 4.7 1619691_at CF211807 TC62520 Q4U339 Hexose transporter (VvHT6) Transport 14 3.69 1613408_at CB347178 TC66667 P93075 Sucrose...”
Q64L87 Xylhp from Debaryomyces fabryi
32% identity, 85% coverage
- Machine learning and comparative genomics approaches for the discovery of xylose transporters in yeast
Fiamenghi, Biotechnology for biofuels and bioproducts 2022 - “...sequence alignment followed by comparison with the InterproScan results for Debaryomyces fabryi Xylhp (Uniprot accession Q64L87). Another interesting feature was GFV tripeptides, which are located on transmembrane portions of the transporters, but their direct relation to xylose transport is unclear. Nonetheless, all predicted transporters had this...”
- “...aligning the xylose transporters and using the sequence of Xylhp from Debaryomyces fabryi (Uniprot accession Q64L87) to predict domains and important sites through Interproscan; then, the non-cytoplasmic domains and probable sugar binding sites were isolated from the alignment and the HMM profile was created. We assumed...”
- Functional survey for heterologous sugar transport proteins, using Saccharomyces cerevisiae as a host
Young, Applied and environmental microbiology 2011 - “...or reference YOUNG ET AL. Y. lipolytica A3LY10 Q64L87 xylHP XUT1 B5RUJ3 DEHA2F19140 S. stipitis B5RSN0 DEHA2A14300 P0AGF4 Q6BW54 DEHA2B14278 xylE Q6BTD8 Q2MEV7...”
SXYL_00132 D-xylose transporter XylE from Staphylococcus xylosus
33% identity, 95% coverage
CNBG_5746 galactose transporter from Cryptococcus deuterogattii R265
31% identity, 81% coverage
- Identification and Characterization of an Intergenic "Safe Haven" Region in Human Fungal Pathogen Cryptococcus gattii
Li, Journal of fungi (Basel, Switzerland) 2022 - “...and CNBG_5898 on chromosome 4; and Candidate 3the 4073 bp intergenic region between CNBG_5745 and CNBG_5746 on chromosome 4. 3.2. Insertion of Foreign DNA into the Candidate 1 or the Candidate 2 Site Has No Significant Impact on the Expression of the Neighboring Genes Our selection...”
- “...CNBG_5897 and CNBG_5898 in the two selected transformants for candidate 2, and of CNBG_5745 and CNBG_5746 in the two selected transformants for candidate 3. The transcript level of CNBG_3433 and CNBG_3434 in the selected transformants for candidate 1 site showed no apparent difference compared to those...”
MAP3834 hypothetical protein from Mycobacterium avium subsp. paratuberculosis str. k10
34% identity, 93% coverage
- Iron Acquisition in Mycobacterium avium subsp. paratuberculosis
Wang, Journal of bacteriology 2015 - “...MAP3764c Polyketide synthase Pks2 14 MAP3770 Cobalamin synthesis protein MAP3775c ABC transporter, ATP-binding protein 15 MAP3834 Sugar transport protein MAP3871 Phosphoribosylglycinamide formyltransferase 2 MAP3883c Beta-lactamase MAP3884 F420-dependent glucose-6-phosphate dehydrogenase MAP4076 Glycosylhydrolase family protein a Genes identified to be enriched (5 median) in the presence of mycobactin...”
Tanf_07060 D-xylose transporter XylE from Tannerella forsythia
33% identity, 87% coverage
M1AVD3 Mannitol transporter from Solanum tuberosum
31% identity, 88% coverage
- Automated identification of reference genes based on RNA-seq data
Carmona, Biomedical engineering online 2017 - “...Calcium-dependent protein kinase 4 Solanum tuberosum rp11_olive_008079 239 204 197 343 275 263 19.34 253.5 M1AVD3 Uncharacterized protein Solanum tuberosum rp11_olive_008883 128 119 144 187 108 118 19.51 134 Q9LZI2 UDP-glucuronic acid decarboxylase 2 Arabidopsis thaliana rp11_olive_035033 178 166 224 177 285 199 19.76 204.8 P62201...”
CNAG_05387 galactose transporter from Cryptococcus neoformans var. grubii H99
32% identity, 83% coverage
- Antifungal activity of eumelanin-inspired indoylenepheyleneethynylene against <i>Cryptococcus neoformans</i>
Conn, Frontiers in microbiology 2023 - “...Gene ID Gene name Log2foldChange p -adjusted Gene description CNAG_01683 STL1 2.362044974 0* Sugar transporter CNAG_05387 1.891607373 0* MFS glucose transporter mfs1 CNAG_01577 2.794167594 0* NADP-specific glutamate dehydrogenase CNAG_06150 2.515378205 0* Heat shock protein 902 CNAG_04630 YAP2 1.495267376 0* Hypothetical protein CNAG_01750 1.7658259 0* Heat shock...”
- A PAS Protein Directs Metabolic Reprogramming during Cryptococcal Adaptation to Hypoxia
Zhao, mBio 2021 - “...of Pas2 in regulating hypoxia-induced metabolic reprogramming. For instance, the genes involved in glycolysis ( CNAG_05387 and CNAG_06290 ), fermentation ( CNAG_01955 , CNAG_04659 , and CNAG_07745 ), gluconeogenesis ( CNAG_04217 ), the PPP ( CNAG_04025 and CNAG_06923 ), and the TCA cycle ( CNAG_06374 )...”
- Galectin-3 impacts Cryptococcus neoformans infection through direct antifungal effects
Almeida, Nature communications 2017 - “...Atg18 XM_012191442.1 3.12 0.0000 2.4 21.4 CNAG_00598 Nicotinamide mononucleotide permease XM_012198344.1 2.87 0.0000 281.5 2069.0 CNAG_05387 Galactose transporter XM_012191781.1 2.84 0.0000 3.5 25.2 CNAG_03666 Acyl-CoA dehydrogenase XM_012193765.1 2.82 0.0001 0.5 3.3 CNAG_00865 Maltose O -acetyltransferase partial XM_012192132.1 2.80 0.0000 8.7 61.1 CNAG_03876 Ras family protein XM_012194860.1...”
- The glucose sensor-like protein Hxs1 is a high-affinity glucose transporter and required for virulence in Cryptococcus neoformans
Liu, PloS one 2013 - “...HXT1 . Meanwhile, HXT2 (CNAG_06290) was induced only by the high glucose concentration, while HXT3 (CNAG_05387) was induced only by low glucose condition ( Fig. 3 ). The changes of transcription level of other tested HXT homologs, HXT4 (CNAG_06521), HXT6 (CNAG_06963) and HXT7 (CNAG_03432), were not...”
ARAE_KLEOX / P45598 Arabinose-proton symporter; Arabinose transporter from Klebsiella oxytoca (see paper)
32% identity, 93% coverage
- function: Uptake of L-arabinose across the cytoplasmic membrane with the concomitant transport of protons into the cell (symport system) (PubMed:7665532). D-fucose, a nonmetabolizable analog of L-arabinose, is also a good substrate (PubMed:7665532).
catalytic activity: H(+)(in) + L-arabinose(in) = H(+)(out) + L-arabinose(out) (RHEA:28951)
catalytic activity: D-fucose(in) + H(+)(in) = D-fucose(out) + H(+)(out) (RHEA:35011) - Major facilitator superfamily
Pao, Microbiology and molecular biology reviews : MMBR 1998 - “...468 469 290 491 220 482 419 388 439 451 P09830 P45598 P37021 P21906 P15729 U29579 X86780 P09098 P31578 P54723 U66480 P46333 P42417 P37514 SP SP SP SP SP GB GB...”
- Cloning, functional analysis, and transcriptional regulation of the Bacillus subtilis araE gene involved in L-arabinose utilization
Sá-Nogueira, Journal of bacteriology 1997 - “...E. coli (E.c.), P09830; AraE from K. oxytoca (K.o.), P45598; GalP from E. coli, P37021; XylE from E. coli, P09098; GlcP from Synechocystis sp. (S.sp.), P15729;...”
TC 2.A.1.1.32 / P15729 Glucose/fructose:H+ symporter, GlcP (see 4 papers)
sll0771 glucose transport protein from Synechocystis sp. PCC 6803
33% identity, 90% coverage
- substrates: fructose, glucose
- Major facilitator superfamily
Pao, Microbiology and molecular biology reviews : MMBR 1998 - “...491 220 482 419 388 439 451 P09830 P45598 P37021 P21906 P15729 U29579 X86780 P09098 P31578 P54723 U66480 P46333 P42417 P37514 SP SP SP SP SP GB GB SP SP SP GB...”
- Cloning, functional analysis, and transcriptional regulation of the Bacillus subtilis araE gene involved in L-arabinose utilization
Sá-Nogueira, Journal of bacteriology 1997 - “...from E. coli, P09098; GlcP from Synechocystis sp. (S.sp.), P15729; Glf from Z. mobilis (Z.m.), P21906. VOL. 179, 1997 B. SUBTILIS araE GENE IN L-ARABINOSE...”
- The genome sequence of Synechocystis sp. PCC 6803 substrain GT-T and its implications for the evolution of PCC 6803 substrains
Koskinen, FEBS open bio 2023 - “...slr1635 Transposase 2044508 ATCAAC Insertion Ile225Asn226 sll1533 pilT2 Pilus retraction protein 2398167 C frameshift G28 sll0771 glcP Glucose transporter 2465926 G T Gln194Lys sll0020 clcP Clp protease ATP binding subunit 2786264 G A Ala61Thr slr0914 Hypothetical protein 3276804 A Intergenic between ORFs sll1342slr1423 The long deletion...”
- “...replicates and the error bars denote SEM. The second frameshift mutation is located in the sll0771 gene that encodes a glucose transporter [ 34 ]. To test whether our GTT strain is able to use externally added glucose, we grew the GTT substrain in photoheterotrophic conditions...”
- CP12 fine-tunes the Calvin-Benson cycle and carbohydrate metabolism in cyanobacteria
Lucius, Frontiers in plant science 2022 - “...might be responsible for the reduced glucose consumption of mutant cp12 , the glucose transporter (Sll0771) and glucose-kinase (Sll0593) encoding genes were sequenced revealing that these genes had identical sequences in mutant as in WT (data not shown). Like mutant cp12 , the strains with mutated...”
- In vivo Inhibition of the 3-Dehydroquinate Synthase by 7-Deoxysedoheptulose Depends on Promiscuous Uptake by Sugar Transporters in Cyanobacteria
Rapp, Frontiers in microbiology 2021 - “...sp. PCC 6803 GT Synechocystis sp. PCC 6803 GT-7dSh R Synechocystis sp. PCC 6803 GT sll0771 :: spec R Synechococcus sp. PCC 7002 Synechococcus sp. PCC 6312 Pleurocapsa minor SAG 4.99 Stanieria cyanosphaera SAG 33.87 Phormidium molle SAG 26.99 Leptolyngbya boryana PCC 6306 Oscillatoria acuminata PCC...”
- “...strain was isolated and then used for bioactivity assays and sequencing (single genes: gtr / sll0771 in Synechocystis sp., frtRABC in A. variabilis , and whole genome sequencing in S. elongatus ). Cloning, Expression, Purification, and Activity of the DHQS From A. variabilis The 3-dehydroquinate synthase...”
- Draft genome sequence of Actinotignum schaalii DSM 15541T: Genetic insights into the lifestyle, cell fitness and virulence
Yassin, PloS one 2017 - “...identities with the glucose transporter GlcP (SCO5578) from Streptomyces coelicolor A3 [ 2 ] and (sll0771) from Synechocystis sp. PCC 6803, respectively. The gene ( G444DRAFT_01316 ), which is annotated as minor myo -inositol:H+ symporter (IolF), clustered with the rhamnose utilization genes rhaDBAMR ( S7 Fig...”
- Metabolic Engineering and Comparative Performance Studies of Synechocystis sp. PCC 6803 Strains for Effective Utilization of Xylose
Ranade, Frontiers in microbiology 2015 - “...possessing non-native transporters was due to activities of both endogenous and heterologous transporters. GlcP ( sll0771 ) is the only known MFS-type glucose transporter identified in Synechocystis ( Lee et al., 2015 ), and this transporter shows an affinity for fructose as well ( Zhang et...”
- Functional proteomic discovery of Slr0110 as a central regulator of carbohydrate metabolism in Synechocystis species PCC6803
Gao, Molecular & cellular proteomics : MCP 2014 - “...using a similar procedure. To create a 6x His-tagged sll0771 knockin construct, a 552-bp DNA fragment at the 3 terminal and before the stop codon of sll0771...”
- “...the mutant, including the only glucose transporter (GlcP, Sll0771) encoded by the Synechocystis genome (Fig. 5A and supplemental Fig. S6) (40, 41). To further...”
- Plasma membrane aquaporin AqpZ protein is essential for glucose metabolism during photomixotrophic growth of Synechocystis sp. PCC 6803
Akai, The Journal of biological chemistry 2011 - “...Mutants--In this study, several mutant strains (glcP (sll0771), sll1961, and aqpZ/glcP) were generated by homologous recombination using plasmids described...”
- Global transcriptional response of the alkali-tolerant cyanobacterium Synechocystis sp. strain PCC 6803 to a pH 10 environment
Summerfield, Applied and environmental microbiology 2008 - “...1.6 1.7 1.9 2.7 1.2 Transport and binding proteins sll0689 sll0771 slr0753 slr0875 slr2057 nhaS3 glcP Transport mscL apqZ 2.1 1.7 1.3 1.4 1.9 1.4 1.5 1.3 1.5...”
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FVEG_11293 hypothetical protein from Fusarium verticillioides 7600
33% identity, 83% coverage
- Involvement of FST1 from Fusarium verticillioides in virulence and transport of inositol
Niu, Molecular plant pathology 2017 (secret) - Transcriptome changes in Fusarium verticillioides caused by mutation in the transporter-like gene FST1
Niu, BMC microbiology 2015 - “...ITR1p sequence identified eight genes with high sequence similarity (FVEG_01519, FVEG_01638, FVEG_02081, FVEG_03992, FVEG_06504, FVEG_07757, FVEG_11293, and FVEG_12687). The sequence of FST1 was not identified by the search. Among the eight identified genes, expression was significantly down-regulated in fst1 for FVEG_06504 (named ITR1 ) (19-fold) and...”
TC 2.A.1.1.65 / A0QZX3 Glucose permease GlcP (Pimentel-Schmitt et al., 2008) (most similar to 2.A.1.1.32) from Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
MSMEG_4182 arabinose-proton symporter from Mycobacterium smegmatis str. MC2 155
35% identity, 86% coverage
- substrates: glucose
- Quantitative mass spectrometry reveals plasticity of metabolic networks in Mycobacterium smegmatis
Chopra, Molecular & cellular proteomics : MCP 2014 - “...predicted as follows: the glucose symporter GlcP (MSMEG_4182) and a glucose-specific phosphotransferase system (MSMEG_21162120) (33). No mRNA transcript of glcP...”
- A VapBC toxin-antitoxin module is a posttranscriptional regulator of metabolic flux in mycobacteria
McKenzie, Journal of bacteriology 2012 - “...with that of VapBC. With the exception of MSMEG_4182 and MSMEG_0515, the values of gene expression from qRT-PCR were statistically significant (, P value...”
- Physiology of mycobacteria
Cook, Advances in microbial physiology 2009 - “...6A ). This bioinformatic prediction was proven recently by the discovery of glucose permease GlcP (Msmeg_4182) from M. smegmatis mc 2 155. Upon overexpression of this protein in a glucose-negative mutant of E. coli it was shown that the strain was capable of glucose fermentation in...”
- A genomic view of sugar transport in Mycobacterium smegmatis and Mycobacterium tuberculosis
Titgemeyer, Journal of bacteriology 2007 - “...73, 77). We found four homologs (msmeg_2966, msmeg_4098, msmeg_4182, and msmeg_5559), of which msmeg_4182 exhibited 53% identity to glucose symporters (Fig. 2)....”
Q7UF68 Xylose transporter from Rhodopirellula baltica (strain DSM 10527 / NCIMB 13988 / SH1)
34% identity, 92% coverage
MAA_02403 hexose transporter from Metarhizium robertsii ARSEF 23
32% identity, 82% coverage
- Carbon translocation from a plant to an insect-pathogenic endophytic fungus
Behie, Nature communications 2017 - “...MST2 during plant root colonization 25 . Metarhizium has three identified monosaccharide transporters (accession numbers: MAA_02403, MAA_03088, MAA_07773), and while these transporters have not been characterized in terms of specific function or location, BLAST analyses show sequence identities with sugar transporters in other root colonizing fungi...”
INT2_ARATH / Q9C757 Probable inositol transporter 2 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
TC 2.A.1.1.63 / Q9C757 Low affinity inositol (myoinsoitol (Km = 1 mM), scylloinositol, d-chiroinositol and mucoinositol):H+ symporter (expressed in the anther tapetum, the vasculature, and the leaf mesophyll from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
NP_174313 INT2 (INOSITOL TRANSPORTER 2); carbohydrate transmembrane transporter/ sugar:hydrogen symporter from Arabidopsis thaliana
AT1G30220, NP_174313 inositol transporter 2 from Arabidopsis thaliana
38% identity, 64% coverage
- function: Plasma membrane inositol-proton symporter. Specific for several inositol epimers, such as myoinositol and scylloinositol. D- chiroinositol, mucoinositol, alloinositol and pinitol are also transported with a lower activity. Not active with galactinol and phytate.
disruption phenotype: No visible phenotype. - substrates: H+, Mucoinositol, Myoinositol, Scylloinositol, d-chiroinositol
- Analysis of cDNA libraries from developing seeds of guar (Cyamopsis tetragonoloba (L.) Taub)
Naoumkina, BMC plant biology 2007 - “...sugar transporter [Arabidopsis] 2e-079 GUAR_UG_04227 1 0 NP_850835 sugar transporter [Arabidopsis] 1e-056 GUAR_UG_02250 1 0 NP_174313 sugar transporter [Arabidopsis] 4e-049 GUAR_UG_00912 2 0 NP_174313 sugar transporter [Arabidopsis] 7e-015 GUAR_UG_02913 1 0 NP_567083 nucleotide-sugar transporter [Arabidopsis] 8e-072 GUAR_UG_03734 1 0 AAU07980 hexose transporter [Vitis vinifera] 2e-055 GUAR_UG_03820...”
- SA and NHP glucosyltransferase UGT76B1 affects plant defense in both SID2- and NPR1-dependent and independent manner
Zhang, Plant cell reports 2024 - “...serine-rich protein-related 1.77 4.27 9.26E-04 AT4G23280 CRK20 1.73 4.29 1.44E-03 AT3G16410 NSP4 1.66 3.27 3.12E-01 AT1G30220 INT2 1.66 4.37 6.89E-04 AT1G17020 SRG1 1.61 4.58 4.12E-03 AT1G10070 BCAT-2 1.58 6.84 2.52E-02 AT3G45130 LAS1 1.51 4.22 7.09E-04 AT4G08770 PRX37 1.47 5.38 9.62E-03 AT5G07100 WRKY26 1.46 7.88 4.05E-03 AT4G10120...”
- From genes to ecosystems: Decoding plant tolerance mechanisms to arsenic stress
Gracia-Rodriguez, Heliyon 2024 - “...Os04g49900 OsABCC7 ATP-binding cassette Arsenite-PC Oryza sativa Root cells Xylem parenchyma cells [ 48 ] At1g30220 AtINT2 Inositol transporters Arsenite A. thaliana Shoot cells Cell membrane [ 62 ] At4g16480 AtINT4 Os01g0142800 OsPTR7 Peptide transporter Dimethylarsinate Oryza sativa Shoot cells Cell membrane [ 63 ] At5g64410...”
- Genome-wide identification, expression, and association analysis of the monosaccharide transporter (MST) gene family in peanut (Arachis hypogaea L.)
Wan, 3 Biotech 2020 - “...AhMST41 AhMST54 AhMST69 AtSTP11 (AT5G23270) STP12 (AT4G21480) AtINT2 (AT1G30220) AtPMT1 (AT2G16120) Stadler et al. (2003), Sherson et al. (2000, 2010) Aluri and...”
- Identification of Circular RNAs from the Parental Genes Involved in Multiple Aspects of Cellular Metabolism in Barley
Darbani, Frontiers in plant science 2016 - “...Ch2:476367671-476368169 Sec 23/ Sec 24 transport protein_circular RNA Ch2:482080734-482081397/MLOC_37573 AT2G27460 Inositol transporter 2_circular RNA Ch2:483514445-483514888/MLOC_38368 AT1G30220 ARID/BRIGHT DNA-binding domain protein_circular RNA Ch2:532048153-532048410 AT2G17410 Alpha-mannosidase 1_circular RNA Ch2:566491430-566492027/MLOC_75116 AT1G51590 Probable long non-coding RNA_circular RNA Ch2:605441109-605441443 Unknown_circular RNA Ch3:100501939-100502294 Mitogen-activated protein kinase ( Ctr 1-like)_circular RNA Ch3:351423944-351425007/MLOC_56360 AT3G58640...”
- RNA-Seq and Gene Network Analysis Uncover Activation of an ABA-Dependent Signalosome During the Cork Oak Root Response to Drought
Magalhães, Frontiers in plant science 2015 - “...PMT5 polyol/monosaccharide transporter 5 QSDrought_01264 Down AT1G11260 STP1 ATSTP1 STP1 sugar transporter 1 QSDrought_02773 Up AT1G30220 ATINT2 ATINT2 INT2 inositol transporter 2 QSDrought_04922 Up AT5G26340 MSS1 ATSTP13 MSS1 STP13 Major facilitator superfamily protein QSDrought_07023 Down AT1G22710 SUC2 ATSUC2 SUC2 SUT1 sucrose-proton symporter 2 Functional Data Mining...”
- Phylloxera (Daktulosphaira vitifoliae Fitch) alters the carbohydrate metabolism in root galls to allowing the compatible interaction with grapevine (Vitis ssp.) roots
Griesser, Plant science : an international journal of experimental plant biology 2015 - “...GSVIVT01010741001 Inositol transporter VvINT1 (at2g43330) 0.65 0.0004 1.0 0.7 0.8 TC113429 GSVIVT01021530001 Inositol transporter VvINT2 (at1g30220) 0.71 0.0113 0.9 * 1.1 1.5 ** TC104946 GSVIVT01034886001 Sucrose transporter VvSUC27 (at1g22710) n.s. n.s. 0.7 ** 0.9 1.8 TC104917 GSVIVT01009254001 Sucrose transporter VvSUT4/VvSUC11 (at1g09960) 0.74 0.0001 1.8 1.5 2.0...”
- High-level expression of sugar inducible gene2 (HSI2) is a negative regulator of drought stress tolerance in Arabidopsis
Sharma, BMC plant biology 2013 - “...activity GO:0016491 2.54 8.39E-04 FERREDOXIN3 At2g27510 F protein ser/thr phosphatase activity GO:0004722 5.43 6.47E-03 PP2CA2 At1g30220 Repressed by Drought and Up-regulated at Stage 1 ( hsi2 :Col-0) P cellular carbohydrate metabolism GO:0044262 4.24 3.01E-03 Cellulose synthase-like B1 At2g32610 F hydrolase activity GO:0016787 1.86 9.05E-03 Methyl IAA...”
- The Vitis vinifera sugar transporter gene family: phylogenetic overview and macroarray expression profiling
Afoufa-Bastien, BMC plant biology 2010 - “...Accession numbers for Arabidopsis thaliana transporters are: At1g20840 (AtTMT1), At4g35300 (AtTMT2), At3g51490 (AtTMT3), At2g43330 (AtINT1), At1g30220 (AtINT2), At2g35740 (AtINT3), At4g16480 (AtINT4), At3g03090 (AtVGT1), At5g17010 (AtVGT2), At5g59250 (AtVGT3), At2g16120 (AtPMT1), At2g16130 (AtPMT2), At2g18480 (AtPMT3), At2g20780 (AtPMT4), At3g18830 (AtPMT5), At4g36670 (AtPMT6); for Vitis ones see Additional file 1...”
- More
BVU_0751 xylose/H+ symporter from Bacteroides vulgatus ATCC 8482
BVU_0751 sugar porter family MFS transporter from Phocaeicola vulgatus ATCC 8482
34% identity, 95% coverage
TC 2.A.1.1.35 / Q7BEC4 The major glucose (or 2-deoxyglucose) uptake transporter, GlcP from Streptomyces lividans (see paper)
SCO5578 sugar transporter from Streptomyces coelicolor A3(2)
SCO7153 sugar transporter from Streptomyces coelicolor A3(2)
32% identity, 90% coverage
- substrates: glucose
- Comparative Proteomic Analysis of Transcriptional and Regulatory Proteins Abundances in S. lividans and S. coelicolor Suggests a Link between Various Stresses and Antibiotic Production
Clara, International journal of molecular sciences 2022 - “...of proteins playing a role in C up-take and assimilation such as the glucose permease (SCO5578) (Figure 16B of [ 9 ]) and all glycolytic enzymes (Figure 2 of [ 9 ]) in SC compared to SL . Similarly, proteins of the Pho regulon involved in...”
- Disentangling the genetic basis of rhizosphere microbiome assembly in tomato
Oyserman, Nature communications 2022 - “...B2R_17968) as well as a glucose permease (B2R_32780) with 91,5% amino acid identity to glcP1 SCO5578 of Streptomyces coelicolor A3(2) 56 . Other genes putatively involved in root exudate catabolism were also found in the ASV5 MAG, such as sarcosine oxidase ( soxBAG , B2R_20550-20551, and...”
- Draft genome sequence of Actinotignum schaalii DSM 15541T: Genetic insights into the lifestyle, cell fitness and virulence
Yassin, PloS one 2017 - “...sugar porters which display 32% and 41% - 44% identities with the glucose transporter GlcP (SCO5578) from Streptomyces coelicolor A3 [ 2 ] and (sll0771) from Synechocystis sp. PCC 6803, respectively. The gene ( G444DRAFT_01316 ), which is annotated as minor myo -inositol:H+ symporter (IolF), clustered...”
- Transcriptomic analysis of a classical model of carbon catabolite regulation in Streptomyces coelicolor
Romero-Rodríguez, BMC microbiology 2016 - “...in a single step (Fig. 3a ). In the Glc/Agar comparison, the genes glcP1 ( SCO5578 ), and glcP2 ( SCO7153 ) showed the highest stimulation exerted by glucose (20-fold increase, and ranked number 1 and 2, respectively) (Fig. 4a ). The transcriptional regulation of glcP...”
- Functional analysis of the GlcP promoter in Streptomyces peucetius var. caesius
Romero, Applied biochemistry and biotechnology 2015 (PubMed)- “...In Streptomyces coelicolor, this protein is encoded by sco5578. However, there is little information about the physiology of the GlcP promoter in Streptomyces....”
- “...analysis of the sp7066 promoter (ortholog of sco5578) from Streptomyces peucetius var. caesius. Hydrophobicity and cellular location analysis of the putative...”
- Comparative genomics of transport proteins in developmental bacteria: Myxococcus xanthus and Streptomyces coelicolor
Getsin, BMC microbiology 2013 - “...Q9KYV5 1.A.22.1.10 MscL, osmotic adaptation channel that influences sporulation and secondary metabolite production. GlcP1/2; Sco7153; Sco5578 [ 103 ] Q7BEC4 2.A.1.1.35 MFS major glucose uptake porters (two identical sequences at the AA level, and having a single substitution on the NT level). MdrA; Sco4007 [ 104...”
- Comparative genomics of transport proteins in developmental bacteria: Myxococcus xanthus and Streptomyces coelicolor
Getsin, BMC microbiology 2013 - “...adaptation channel that influences sporulation and secondary metabolite production. GlcP1/2; Sco7153; Sco5578 [ 103 ] Q7BEC4 2.A.1.1.35 MFS major glucose uptake porters (two identical sequences at the AA level, and having a single substitution on the NT level). MdrA; Sco4007 [ 104 ] Q9ADP8 2.A.1.36.4 Putative...”
- Transcriptomic analysis of a classical model of carbon catabolite regulation in Streptomyces coelicolor
Romero-Rodríguez, BMC microbiology 2016 - “...3a ). In the Glc/Agar comparison, the genes glcP1 ( SCO5578 ), and glcP2 ( SCO7153 ) showed the highest stimulation exerted by glucose (20-fold increase, and ranked number 1 and 2, respectively) (Fig. 4a ). The transcriptional regulation of glcP was dependent on the presence...”
- Comparative genomics of transport proteins in developmental bacteria: Myxococcus xanthus and Streptomyces coelicolor
Getsin, BMC microbiology 2013 - “...] Q9KYV5 1.A.22.1.10 MscL, osmotic adaptation channel that influences sporulation and secondary metabolite production. GlcP1/2; Sco7153; Sco5578 [ 103 ] Q7BEC4 2.A.1.1.35 MFS major glucose uptake porters (two identical sequences at the AA level, and having a single substitution on the NT level). MdrA; Sco4007 [...”
GOX0808 Galactose-proton symporter from Gluconobacter oxydans 621H
34% identity, 94% coverage
BT_3606 sugar-proton symporter from Bacteroides thetaiotaomicron VPI-5482
33% identity, 91% coverage
GRMZM2G063824 carbohydrate transporter/ sugar porter from Zea mays
31% identity, 86% coverage
- Transcriptome Analysis of Maize Ear Leaves Treated with Long-Term Straw Return plus Nitrogen Fertilizer under the Wheat-Maize Rotation System
Li, Plants (Basel, Switzerland) 2023 - “...two genes encoding beta-glucosidase 1 ( GRMZM2G016890 and GBA1 ), GRMZM2G066162 encoding endoglucanase 12-like and GRMZM2G063824 encoding carbohydrate transporter/sugar porter were significantly up-regulated in N treatment, but their expression level kept the same as in SR and SRN treatments. There were three DEGs ( GRMZM2G178014 ,...”
- “...the regulation of sugar transport. In this work, two sugar transporter genes ( GRMZM2G157675 and GRMZM2G063824 ) showed quite opposite expression patterns in N treatment, but their expression level did not change in SR and SRN treatment. It indicated that sugar transport in maize leaf was...”
- Analysis of weighted co-regulatory networks in maize provides insights into new genes and regulatory mechanisms related to inositol phosphate metabolism
Zhang, BMC genomics 2016 - “...were related to carbohydrate metabolism. Representative genes include a UDP-galactose transporter (GRMZM2G089630, node CD2), carbohydrate/inositol-transporters (GRMZM2G063824, GRMZM2G064437, nodes CA1 and CC1), and a glycerol-3-phosphate transporter (GRMZM2G078757, node CC4). The correlation between IP6 levels and the expression of carbohydrate transporters (correlation coefficient ranged from 0.51 to 0.95,...”
- Transcriptional analyses of natural leaf senescence in maize
Zhang, PloS one 2014 - “...(AtPLT5) Abscission control [97] GRMZM2G302604 AT3G18830 ARABIDOPSIS THALIANA POLYOL/MONOSACCHARIDE TRANSPORTER 5 (AtPLT5) Abscission control [97] GRMZM2G063824 AT3G18830 ARABIDOPSIS THALIANA POLYOL/MONOSACCHARIDE TRANSPORTER 5 (AtPLT5) Abscission control [97] GRMZM5G862325 AT3G18830 ARABIDOPSIS THALIANA POLYOL/MONOSACCHARIDE TRANSPORTER 5 (AtPLT5) Abscission control [97] GRMZM2G339563 AT3G44880 PHEOPHORBIDE A OXYGENASE (PAO) Positive regulator in...”
TC 2.A.1.1.40 / Q64L87 The xylose facilitator, Xylhp from Debaryomyces hansenii (Yeast) (Torulaspora hansenii)
32% identity, 85% coverage
P93075 BvcDNA-205 protein from Beta vulgaris subsp. vulgaris
29% identity, 83% coverage
- CuGenDBv2: an updated database for cucurbit genomics.
Yu, Nucleic acids research 2023 - “...two genome assemblies from the cultivated sponge gourd species L. cylindrica including that of cultivar P93075, and one from another cultivated species L. acutangula (AG-4) are available ( 2527 ). For Momordica , two genome assemblies from the cultivated bitter gourd species M. charantia (Dali-11 and...”
- “...( 30 ) Sponge gourd Luffa cylindrica v1 31 661 ( 25 ) Luffa cylindrica P93075 v1 27 147 ( 27 ) Luffa acutangula AG-4 v1 42 211 ( 26 ) Wax gourd Benincasa hispida B227 v1 27 467 ( 32 ) Chayote Sechium edule v1...”
- QTL mapping reveals candidate genes for main agronomic traits in Luffa based on a high-resolution genetic map
Liu, Frontiers in plant science 2022 - “...population of 110 lines derived from a cross between S1174 ( Luffa acutangula ) and P93075 ( Luffa cylindrica ). The map spanned a total of 2246.74 cM with an average distance of 0.48 cM between adjacent markers. Thereafter, a large-scale field-based quantitative trait loci (QTLs)...”
- “...for some nonsynonymous single nucleotide polymorphisms (SNPs) in exons, and the expression level in thick-stem P93075 was distinctively higher than that in thin-stem S1174. According to the natural variation analysis of a population of 183 inbred lines, two main haplotypes were found for LacCRWN3 : the...”
- Identification of suitable reference genes for quantitative reverse transcription PCR in Luffa (Luffa cylindrica)
Zhao, Physiology and molecular biology of plants : an international journal of functional plant biology 2022 - “...and methods Plant materials and tissue collection P93075, an advanced Luffa inbred line bred through multiple generations of self-pollination and selection,...”
- A high-quality sponge gourd (Luffa cylindrica) genome.
Wu, Horticulture research 2020 - “...family Cucurbitaceae. In this study, a draft genome sequence of the sponge gourd inbred line P93075 was analyzed. Using Illumina, PacBio, and 10 Genomics sequencing techniques as well as new assembly techniques such as FALCON and chromatin interaction mapping (Hi-C), a chromosome-scale genome of approximately 656.19Mb,...”
- “...assembly, and quality evaluation To assess the genome size of the sponge gourd inbred line P93075 (Fig. 1 , Supplementary Fig. 1 ), 144.34Gb of paired-end reads (with an insert size of 350bp) were selected to generate 17-mer frequency data for k -mer analysis. The k...”
- Transcriptomic and metabolite analyses of Cabernet Sauvignon grape berry development
Deluc, BMC genomics 2007 - “...15 4.7 1619691_at CF211807 TC62520 Q4U339 Hexose transporter (VvHT6) Transport 14 3.69 1613408_at CB347178 TC66667 P93075 Sucrose transporter (BvST1) Transport 11 2.92 1608991_at CA816013 TC60060 Q8GTR0 Sugar transporter Transport 10 2.86 1610298_at CB972367 TC53493 Q8LES0 Golgi nucleotide sugar transporter (GONST) 4 Transport 2 2.71 1615697_at AF021810...”
SCLAV_4529 sugar porter family MFS transporter from Streptomyces clavuligerus
32% identity, 89% coverage
AT2G16130 mannitol transporter, putative from Arabidopsis thaliana
NP_179210 polyol/monosaccharide transporter 2 from Arabidopsis thaliana
31% identity, 86% coverage
- Single-cell RNA-seq reveals a link of ovule abortion and sugar transport in Camellia oleifera
Zhao, Frontiers in plant science 2024 - “...transport both glucose and fructose ( Norholm etal., 2006 ; Liu etal., 2021b ). AtPMT2 (AT2G16130, a homologue of CoPLT2) protein is a glucose, fructose, and xylitol/H + symporter localized to the plasma membrane in pollen and young xylem cells ( Klepek etal., 2010 ). AtSUC2...”
- Arabidopsis thaliana POLYOL/MONOSACCHARIDE TRANSPORTERS 1 and 2: fructose and xylitol/H+ symporters in pollen and young xylem cells
Klepek, Journal of experimental botany 2010 - “...membrane-localized H + -symporter with broad substrate specificity. The characterization of AtPMT1 (At2g16120) and AtPMT2 (At2g16130), two other, almost identical, members of this transporter subfamily, are presented here. Expression of the AtPMT1 and AtPMT2 cDNAs in baker's yeast ( Saccharomyces cerevisiae ) revealed that these proteins...”
- “...al. , 2005 ). Two of these genes, AtPMT1 ( At2g16120 ) and AtPMT2 ( At2g16130 ), are located on chromosome 2 with their start ATGs being separated by 6881 nucleotides. Both genes are interrupted by 2 introns, and in both genes these introns are inserted...”
- The Vitis vinifera sugar transporter gene family: phylogenetic overview and macroarray expression profiling
Afoufa-Bastien, BMC plant biology 2010 - “...(AtINT1), At1g30220 (AtINT2), At2g35740 (AtINT3), At4g16480 (AtINT4), At3g03090 (AtVGT1), At5g17010 (AtVGT2), At5g59250 (AtVGT3), At2g16120 (AtPMT1), At2g16130 (AtPMT2), At2g18480 (AtPMT3), At2g20780 (AtPMT4), At3g18830 (AtPMT5), At4g36670 (AtPMT6); for Vitis ones see Additional file 1 . Vitis ORFs names were simplified, Vv indicating GSVIVT000. Vitis vinifera putative Polyol/Monosaccharide Transporters...”
- A label-free differential quantitative mass spectrometry method for the characterization and identification of protein changes during citrus fruit development
Katz, Proteome science 2010 - “...44184 AT1G61800 2 0.10 28.2 12.3 -1 -- -- 0.8 1.2 0 mannitol transporter 32978 AT2G16130 -- -- 439 18.8 -1 -- -- 5.8 3.2 0 LPT(lipid transfer protein) 45077 AT1G27950 2 0.01 5258.00 22.44 -1 -- -- -- -- -- LTP3 58907 AT5G59320 -- --...”
- Arabidopsis thaliana POLYOL/MONOSACCHARIDE TRANSPORTERS 1 and 2: fructose and xylitol/H+ symporters in pollen and young xylem cells.
Klepek, Journal of experimental botany 2010 - GeneRIF: AtPMT1 and AtPMT2 are xylitol and fructose transporters in pollen and young xylem.
TC 2.A.1.1.123 / AIU41385.1 Sorbitol (D-Glucitol):H+ co-transporter, SOT1 (Km for sorbitol of 0.64 mM) of 509 aas and 12 TMSs (Gao et al. 2003). SOT1 of P. cerasus is expressed throughout fruit development, but especially when growth and sorbitol accumulation rates are highest. In leaves, PcSOT1 expression is highest in young, expanding tissues, but substantially less in mature leaves from Prunus salicina
31% identity, 85% coverage
XP_828610 sugar transporter, putative from Trypanosoma brucei brucei TREU927
33% identity, 93% coverage
B4FQN6 Putative polyol transporter 1 from Zea mays
GRMZM2G153920 sorbitol transporter from Zea mays
31% identity, 81% coverage
- Growth Stimulatory Effects and Genome-Wide Transcriptional Changes Produced by Protein Hydrolysates in Maize Seedlings.
Santi, Frontiers in plant science 2017 - “...GRMZM2G024808_T01 B6U7W3 Nitrate and chloride transporter 2.02 GRMZM2G072955_T01 M8CTF4 Chloride channel protein 2.06 2.02 GRMZM2G153920_T01 B4FQN6 Sorbitol transporter 2.07 GRMZM2G137421_T01 B6TSV4 Peptide transporter PTR2 2.09 2.12 GRMZM2G457523_T01 Q2QLJ1 Sodium/hydrogen exchanger family protein, expressed 2.10 GRMZM5G872392_T01 B6T9U6 Bidirectional sugar transporter SWEET 2.15 AC186166.3_FGT008 A0A096PGB1 Uncharacterized protein 2.16...”
- Quantitative Proteomic Analyses Identify ABA-Related Proteins and Signal Pathways in Maize Leaves under Drought Conditions
Zhao, Frontiers in plant science 2016 - “...0.900 0.862 0.854 1.617 0.000 0.872 0.018 0.000 Up-regulated by drought in an ABA-dependent way B4FQN6 Sorbitol transporter 0.682 0.647 0.657 1.332 1.324 1.346 0.662 0.005 1.334 0.005 0.000 Down-regulated by drought in an ABA-dependent way B4FRG9 Uncharacterized protein 0.620 0.585 0.595 0.952 0.944 0.966 0.600...”
- Brevis plant1, a putative inositol polyphosphate 5-phosphatase, is required for internode elongation in maize
Avila, Journal of experimental botany 2016 - “...2.81 Transcription factor GRMZM2G169149 WRKY62-superfamily of transcription factors having WRKY 0.00 0.00 10.87 3.91 Transport GRMZM2G153920 Sorbitol transporter; uncharacterized 0.00 0.00 1.15 0.98 Zm_mod04;-0.49 Transposon GRMZM2G021020 Transposable element 22.24 22.90 0.00 0.00 GRMZM2G008283 Transposable element 15.17 33.16 0.0 0.0 GRMZM2G020508 Transposable element 4.44 4.11 12.96 13.87...”
- “...responsible for the majority of -galactose activity against xyloglucan. Misexpressed genes encoding membrane-associated transporters include GRMZM2G153920 and GRMZM2G180659. The sorbitol transporter-like protein GRMZM2G153920 is up-regulated in bv1 relative to wild-type internodes. Sorbitol transporter-like proteins can transport pentoses as well as polyols and different hexoses ( Klepek...”
- Correlation of aquaporins and transmembrane solute transporters revealed by genome-wide analysis in developing maize leaf
Yue, Comparative and functional genomics 2012 - “...an ion-coupled uptake transporter [ 52 ]. Our results showed that ATPLT5 (polyol transporter 5, GRMZM2G153920, EntrezGene:100281055) exhibited the same expression patterns as ZmNIP2;1 and may be involved in sugar and substrate-specific transmembrane transporter activity (GO:0022891). From our results, we also observed significant relationships between the...”
E6RCH7 High-affinity glucose transporter of the major facilitator superfamily, putative Hxt4p from Cryptococcus gattii serotype B (strain WM276 / ATCC MYA-4071)
32% identity, 83% coverage
- Phenotypic characteristics and transcriptome profile of Cryptococcus gattii biofilm
Tavares, Scientific reports 2019 - “...process Ergosterol biosynthetic process CGB_J0030W 4,798 ADV24539 High-affinity glucose transporter of the major facilitator superfamily E6RCH7 High-affinity glucose transporter of the major facilitator superfamily Transmembrane transport CGB_F0090C 14,363 ADV22816 Monocarboxylic acid transporter E6R7J0 Monocarboxylic acid transporter Transmembrane transport Ion transmembrane transport CGB_M2010W 9,461 ADV25506 dUTP diphosphatase...”
Q90592 Solute carrier family 2, facilitated glucose transporter member 2 from Gallus gallus
35% identity, 77% coverage
BBA_03013 hexose transporter from Beauveria bassiana ARSEF 2860
32% identity, 82% coverage
- Nuclear Ssr4 Is Required for the In Vitro and In Vivo Asexual Cycles and Global Gene Activity of Beauveria bassiana
Shao, mSystems 2020 - “...the pentose phosphate pathway and the Calvin cycle ( 38 ), six hexose transporters (BBA_05766, BBA_03013, BBA_00397, BBA_09477, BBA8728, and BBA5674) critical for glucose uptake ( 39 ), and most of the glycosyl hydrolases (BBA_03946, BBA_05847, BBA_09379, and BBA_08796) involved in the hydrolysis of glycosidic bonds,...”
FTN_0688 galactose-proton symporter, major facilitator superfamily (MFS) transport protein from Francisella tularensis subsp. novicida U112
33% identity, 95% coverage
- Genotype-phenotype associations in a nonmodel prokaryote
Enstrom, mBio 2012 - “...kinase (FTN_0646), which appears to act on both fructose and mannose, and a predicted transporter (FTN_0688), which appears to import fructose. Mutations in FTN_0511 and FTN_0512 ( glgX ) also led to fructose-negative phenotypes. Download FigureS2, PDF file, 0.1 MB . FigureS2, PDF file, 0.1 MB...”
- Molecular bases of proliferation of Francisella tularensis in arthropod vectors
Asare, Environmental microbiology 2010 - “...as FTN_0984 (transport) exhibited only a slight reduction in growth whereas some mutants such as FTN_0688 (transport) showed higher levels of growth compared to the wild type strain ( Table 4 ). Thirteen out of 24 mutants from the hypothetical proteins functional category were found to...”
- “...metabolite:H+ symporter (MHS) family protein 5 # tnfn1_pw060418p02q189 FTN_0640 dctA C4-dicarboxylate transport protein 3 tnfn1_pw060510p02q159 FTN_0688 galP2 galactose-proton symporter, major facilitator superfamily (MFS) transport protein 3 tnfn1_pw060510p03q140 FTN_0741 proton-dependent oligopeptide transporter (POT) family protein, di- or tripeptide:H+ symporter 5 tnfn1_pw060328p05q107 FTN_0767 betT betaine/carnitine/choline transporter (BCCT) family...”
- Molecular complexity orchestrates modulation of phagosome biogenesis and escape to the cytosol of macrophages by Francisella tularensis
Asare, Environmental microbiology 2010 - “...metabolite:H+ symporter (MHS) family protein 5 # tnfn1_pw060418p02q189 FTN_0640 dctA C4-dicarboxylate transport protein 3 tnfn1_pw060510p02q159 FTN_0688 galP2 galactose-proton symporter, major facilitator superfamily (MFS) transport protein 3 tnfn1_pw060510p03q140 FTN_0741 proton-dependent oligopeptide transporter (POT) family protein, di-or tripeptide:H+ symporter 5 tnfn1_pw060328p05q107 FTN_0767 betT betaine/carnitine/choline transporter (BCCT) family protein...”
NP_997061 solute carrier family 2, facilitated glucose transporter member 2 from Gallus gallus
35% identity, 76% coverage
Pc22g09740 uncharacterized protein from Penicillium rubens
31% identity, 80% coverage
XP_006237358 solute carrier family 2, facilitated glucose transporter member 3 isoform X1 from Rattus norvegicus
32% identity, 89% coverage
- Fructose-rich diet and walnut supplementation differently regulate rat hypothalamic and hippocampal glucose transporters expression.
Dakic, Journal of the science of food and agriculture 2021 (PubMed)- GeneRIF: Fructose-rich diet and walnut supplementation differently regulate rat hypothalamic and hippocampal glucose transporters expression.
- Aging alters glucose uptake in the naïve and injured rodent spinal cord.
von, Neuroscience letters 2019 - GeneRIF: findings show that age alters glucose uptake and GLUT3/4 expression profiles before and after Spinal Cord Injury.
- Altered lactate metabolism in Huntington's disease is dependent on GLUT3 expression.
Solís-Maldonado, CNS neuroscience & therapeutics 2018 - GeneRIF: Study found no differences in mRNA or protein levels of neuronal monocarboxylate transporters (MCTs). Functional analyses revealed that neuronal MCT2 had high catalytic efficiency in Huntington's disease (HD) cells. Ascorbic acid did not stimulate lactate uptake in HD cells; and was unable to inhibit glucose transport in HD cells because they exhibit decreased expression of the neuronal glucose transporter GLUT3.
- Chronic stress modulates regional cerebral glucose transporter expression in an age-specific and sexually-dimorphic manner.
Kelly, Physiology & behavior 2014 - GeneRIF: Hippocampal mRNA abundance of GLUT3 decreases with age in males and females
- Extracellular ATP-prinoceptor signaling and AMP-activated protein kinase regulate astrocytic glucose transporter 3 in an in vitro ischemia.
Iwabuchi, Neurochemistry international 2013 (PubMed)- GeneRIF: results suggest AMPK-regulated ATP production triggers the release of ATP to activate P2Y receptor signaling, which is another candidate that regulates GLUT3 expression under the ischemic condition
- IGF-1 induces hypoxia-inducible factor 1α-mediated GLUT3 expression through PI3K/Akt/mTOR dependent pathways in PC12 cells.
Yu, Brain research 2012 (PubMed)- GeneRIF: Expression of GLUT3 in response to IGF-1 is dependent on phosphatidylinositol (PI)-3-kinase and mTOR activity and requires transcription factor HIF-1alpha in neuronal PC12 cells.
- Triiodothyronine stimulates glucose transport in bone cells.
Zoidis, Endocrine 2012 (PubMed)- GeneRIF: Data suggest that triiodothyronine (T3) up-regulates Glut1 and Glut3 in osteoblasts; thus, increased glucose uptake induced by T3 may be mediated by these high-affinity glucose transporters.
- The expression of genes involved in glucose metabolism is affected by N-methyl-D-aspartate receptor antagonism: a putative link between metabolism and an animal model of psychosis.
Iasevoli, Journal of neuroscience research 2012 (PubMed)- GeneRIF: The results show that Hk1 and GLUT3 may play a role in the pathophysiology of ketamine-induced behavioral abnormalities.
- More
TC 2.A.1.1.75 / Q9XIH7 The fructose/xylose:H+ symporter, PMT1 (polyol monosaccharide transporter-1). Also transports other substrates at lower rates. PMT2 is largely of the same sequence and function. Both are present in pollen and young xylem cells (Klepek et al., 2005). A similar ortholog has been identifed in pollen grains of Petunia hybrida from Arabidopsis thaliana (see 2 papers)
AT2G16120 mannitol transporter, putative from Arabidopsis thaliana
NP_179209 polyol/monosaccharide transporter 1 from Arabidopsis thaliana
31% identity, 86% coverage
- substrates: H+, Xylose, fructose
- Genome-wide identification, expression, and association analysis of the monosaccharide transporter (MST) gene family in peanut (Arachis hypogaea L.)
Wan, 3 Biotech 2020 - “...AhMST69 AtSTP11 (AT5G23270) STP12 (AT4G21480) AtINT2 (AT1G30220) AtPMT1 (AT2G16120) Stadler et al. (2003), Sherson et al. (2000, 2010) Aluri and Buttner (2007)...”
- Meta-analysis of the expression profiles of the Arabidopsis ESCRT machinery
Richardson, Plant signaling & behavior 2011 - “...sequence-specific DNA-binding transcription factor activity AT2G16120 Polyol/monosaccharide transporter 1 AT1G57906 Unknown protein AT5G52050 MATE efflux family...”
- Arabidopsis thaliana POLYOL/MONOSACCHARIDE TRANSPORTERS 1 and 2: fructose and xylitol/H+ symporters in pollen and young xylem cells
Klepek, Journal of experimental botany 2010 - “...be a plasma membrane-localized H + -symporter with broad substrate specificity. The characterization of AtPMT1 (At2g16120) and AtPMT2 (At2g16130), two other, almost identical, members of this transporter subfamily, are presented here. Expression of the AtPMT1 and AtPMT2 cDNAs in baker's yeast ( Saccharomyces cerevisiae ) revealed...”
- “...transporter AtPMT5 (At3g18830; Klepek et al. , 2005 ). Two of these genes, AtPMT1 ( At2g16120 ) and AtPMT2 ( At2g16130 ), are located on chromosome 2 with their start ATGs being separated by 6881 nucleotides. Both genes are interrupted by 2 introns, and in both...”
- The Vitis vinifera sugar transporter gene family: phylogenetic overview and macroarray expression profiling
Afoufa-Bastien, BMC plant biology 2010 - “...(AtTMT3), At2g43330 (AtINT1), At1g30220 (AtINT2), At2g35740 (AtINT3), At4g16480 (AtINT4), At3g03090 (AtVGT1), At5g17010 (AtVGT2), At5g59250 (AtVGT3), At2g16120 (AtPMT1), At2g16130 (AtPMT2), At2g18480 (AtPMT3), At2g20780 (AtPMT4), At3g18830 (AtPMT5), At4g36670 (AtPMT6); for Vitis ones see Additional file 1 . Vitis ORFs names were simplified, Vv indicating GSVIVT000. Vitis vinifera putative...”
- A pair of phospho-base methyltransferases important for phosphatidylcholine biosynthesis in Arabidopsis.
Liu, The Plant journal : for cell and molecular biology 2018 (PubMed)- GeneRIF: a phospho-base methyltransferases important for phosphatidylcholine biosynthesis
- Arabidopsis thaliana POLYOL/MONOSACCHARIDE TRANSPORTERS 1 and 2: fructose and xylitol/H+ symporters in pollen and young xylem cells.
Klepek, Journal of experimental botany 2010 - GeneRIF: AtPMT1 and AtPMT2 are xylitol and fructose transporters in pollen and young xylem.
GTR1_DROME / Q8IRI6 Glucose transporter type 1 from Drosophila melanogaster (Fruit fly) (see paper)
32% identity, 30% coverage
- function: Facilitative glucose transporter.
GTR1_RAT / P11167 Solute carrier family 2, facilitated glucose transporter member 1; Glucose transporter type 1, erythrocyte/brain; GLUT-1 from Rattus norvegicus (Rat) (see 6 papers)
NP_620182 solute carrier family 2, facilitated glucose transporter member 1 from Rattus norvegicus
33% identity, 90% coverage
- function: Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake (PubMed:2211693). Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses (By similarity). Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain (By similarity). In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors (By similarity). Required for mesendoderm differentiation (By similarity).
catalytic activity: D-glucose(out) = D-glucose(in) (RHEA:60376)
subunit: Found in a complex with ADD2, DMTN and SLC2A1. Interacts (via C-terminus cytoplasmic region) with DMTN. Interacts with SNX27; the interaction is required when endocytosed to prevent degradation in lysosomes and promote recycling to the plasma membrane. Interacts with STOM (By similarity). Interacts with GIPC (via PDZ domain) (PubMed:10198040). Interacts with SGTA (via Gln-rich region) (PubMed:15708368). Interacts with isoform 1 of BSG (By similarity). Interacts with SMIM43; the interaction may promote SLC2A1-mediated glucose transport to meet the energy needs of mesendoderm differentiation (By similarity). - Increased GLUT1 expression and localization to Golgi apparatus of acinar cells in the parotid gland of Goto-Kakizaki diabetic rats.
Maruo, Archives of oral biology 2023 (PubMed)- GeneRIF: Increased GLUT1 expression and localization to Golgi apparatus of acinar cells in the parotid gland of Goto-Kakizaki diabetic rats.
- A glucose-sensing mechanism with glucose transporter 1 and pyruvate kinase in the area postrema regulates hepatic glucose production in rats.
Li, The Journal of biological chemistry 2023 - GeneRIF: A glucose-sensing mechanism with glucose transporter 1 and pyruvate kinase in the area postrema regulates hepatic glucose production in rats.
- Intermedin alleviates diabetic vascular calcification by inhibiting GLUT1 through activation of the cAMP/PKA signaling pathway.
Zhang, Atherosclerosis 2023 (PubMed)- GeneRIF: Intermedin alleviates diabetic vascular calcification by inhibiting GLUT1 through activation of the cAMP/PKA signaling pathway.
- Measurements of basal d-glucose transport through GLUT1 across the intact plasma membrane of isolated segments from single fast- and slow-twitch skeletal muscle fibres of rat.
Rudayni, Acta physiologica (Oxford, England) 2022 - GeneRIF: Measurements of basal d-glucose transport through GLUT1 across the intact plasma membrane of isolated segments from single fast- and slow-twitch skeletal muscle fibres of rat.
- Cortical Dysplasia in Rats Provokes Neurovascular Alterations, GLUT1 Dysfunction, and Metabolic Disturbances That Are Sustained Post-Seizure Induction.
Ghosh, Molecular neurobiology 2022 - GeneRIF: Cortical Dysplasia in Rats Provokes Neurovascular Alterations, GLUT1 Dysfunction, and Metabolic Disturbances That Are Sustained Post-Seizure Induction.
- PPARγ alleviates peritoneal fibrosis progression along with promoting GLUT1 expression and suppressing peritoneal mesothelial cell proliferation.
Feng, Molecular and cellular biochemistry 2022 - GeneRIF: PPARgamma alleviates peritoneal fibrosis progression along with promoting GLUT1 expression and suppressing peritoneal mesothelial cell proliferation.
- Impact of hyperglycemia on the expression of GLUT1 during oral carcinogenesis in rats.
Dalal, Molecular biology reports 2022 (PubMed)- GeneRIF: Impact of hyperglycemia on the expression of GLUT1 during oral carcinogenesis in rats.
- Fetal Myocardial Expression of GLUT1: Roles of BPA Exposure and Cord Blood Exosomes in a Rat Model.
Ermini, Cells 2022 - GeneRIF: Fetal Myocardial Expression of GLUT1: Roles of BPA Exposure and Cord Blood Exosomes in a Rat Model.
- More
- Proteomics Reveals the Potential Protective Mechanism of Hydrogen Sulfide on Retinal Ganglion Cells in an Ischemia/Reperfusion Injury Animal Model
Liu, Pharmaceuticals (Basel, Switzerland) 2020 - “...Atp2b2 0.0227347 low Q7TP47 Syncrip 0.0239965 low Q8NCB2 CAMKV 0.0247766 low P14854 COX6B1 0.0270203 low P11167 Slc2a1 0.0276784 low P45479 Ppt1 0.0279009 high Q9QZA2 Pdcd6ip 0.0299058 low P41498 Acp1 0.032686 high P10155 TROVE2 0.0333496 high Q64428 Hadha 0.0337918 low P83916 CBX1 0.0342579 high Q64560 Tpp2 0.0352463...”
- Membrane Protein Identification in Rodent Brain Tissue Samples and Acute Brain Slices
Joost, Cells 2019 - “...5 4 5 Transporters Q9JHZ9 System N amino acid transporter 1 10 2 0 1 P11167 Solute carrier family 2, facilitated glucose transporter member 1 11 3 3 2 Q8VII6 Choline transporter-like protein 1 10 1 1 0 Q63016 Large neutral amino acids transporter small subunit...”
- Stress alters the expression of cancer-related genes in the prostate.
Flores, BMC cancer 2017 - “...inhibitor/apoptosis Skp2 B2GUZ0 S-phase kinase-associated protein 2 (p45) 1.56 1.67 Ubiquitin ligase/cell cycle regulation Slc2a1 P11167 Solute carrier family 2 (facilitated glucose transporter, member 1 1.25 1.32 Glucose transporter/metabolism (nutrient uptake) Tinf2 Q5XIB8 TERF 1 (TRF1)- interacting nuclear factor 2 4.29 6.11 Telomeric DNA binding/chrosomome stability...”
- Eggshell membrane ameliorates hepatic fibrogenesis in human C3A cells and rats through changes in PPARγ-Endothelin 1 signaling.
Jia, Scientific reports 2014 - “...P02466 Collagen alpha-2(I) chain Col1a2 1.14 0.94 P62828 GTP-binding nuclear protein Ran Ran 1.58 0.81 P11167 Solute carrier family 2, facilitated glucose transporter member 1 Slc2a1 2.12 0.61 P13221 Aspartate aminotransferase, cytoplasmic Got1 1.02 0.83 P67874 Casein kinase II subunit beta Csnk2b 1.21 0.67 P48675 Desmin...”
- Age-related changes in the retinal pigment epithelium (RPE).
Gu, PloS one 2012 - “...58 6.1 Y & A Solute carrier family 2, facilitated glucose transporter member 1 (Glut-1) P11167 55 13.0 Y & A Sulfated glycoprotein 1 (SGP-1) (Prosaposin) P10960 40 25.5 Y & A Transmembrane emp24 domain-containing protein 4 B5DEM3 30 12.8 A Ubiquitin carboxyl-terminal hydrolase 19 Q6J1Y9...”
- Carbon source metabolism and its regulation in cancer cells.
Yin, Critical reviews in eukaryotic gene expression 2012 - “...2 Major Metabolic Enzymes Up-regulated by HIF-1 Genes Swiss Prot Reference Slc2a1 Glucose transporter 1 P11167 119 HK2 Hexokinase 2 P52789 120 Ldha Lactate dehydrogenase A P06151 121 PDK1 pyruvate dehydrogenase kin; ase 1 Q15118 40 CAIX carbonic anhydrase IX Q8VHB5 42 MCT4 Monocarboxylate transporter4 Q15427...”
- “...3 Major Metabolic Enzymes Up-regulated by c-Myc Genes Swiss Prot Reference Slc2a1 Glucose transporter 1 P11167 47 HK2 Hexokinase 2 P52789 46 Ldha Lactate dehydrogenase A P06151 45 PDK1 Pyruvate dehydrogenase kinase 1 Q15118 46 Pfkl Phosphofructokinase (PFK1) P30835 47 Eno1 Enolase 1 P04764 47 TABLE...”
- A microarray study of gene and protein regulation in human and rat brain following middle cerebral artery occlusion.
Mitsios, BMC neuroscience 2007 - “...0.6-fold 26 37 2.4-fold 3 days 0.05-fold 21 days Glucose Transporter 1 K03195 P11166 M13979 P11167 0.6-fold 26 37 11.6-fold 4 h 21 d Amongst these genes we examined in more detail a small subset with no prior report of a role in stroke (PAK1, MMP11...”
- High-throughput identification of IMCD proteins using LC-MS/MS.
Pisitkun, Physiological genomics 2006 - More
Afu2g05190 MFS monosaccharide transporter, putative from Aspergillus fumigatus Af293
31% identity, 80% coverage
- Evolutionary Analysis of Sequence Divergence and Diversity of Duplicate Genes in Aspergillus fumigatus
Yang, Evolutionary bioinformatics online 2012 - “...1.43 [0.77, 2.58] Afu1g16080 2.53 [0.27, 3.04] Afu5g14990 2.78 [2.06, 0.45] Afu5g00280 2.43 [0.27, 2.94] Afu2g05190 0.61 [1.22, 2.18] Afu7g01690 2.41 [0.35, 3.07] Afu8g05220 2.61 [2.09, 0.65] Afu3g00670 2.39 [0.59, 3.44] Afu5g13060 2.60 [2.05, 0.60] Afu6g12820 2.37 [2.06, 6.42] Afu2g12200 0.65 [1.79, 1.77] Afu6g02420 2.35 [2.02,...”
TC 2.A.1.1.81 / Q0SE66 The glucose uptake porter, GluP from Rhodococcus sp. (strain RHA1) (see paper)
33% identity, 88% coverage
GTR1_BOVIN / P27674 Solute carrier family 2, facilitated glucose transporter member 1; Glucose transporter type 1, erythrocyte/brain; GLUT-1 from Bos taurus (Bovine) (see paper)
NP_777027 solute carrier family 2, facilitated glucose transporter member 1 from Bos taurus
XP_006068373 solute carrier family 2, facilitated glucose transporter member 1 isoform X1 from Bubalus bubalis
33% identity, 90% coverage
- function: Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain (By similarity). In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors (By similarity). Required for mesendoderm differentiation (By similarity).
catalytic activity: D-glucose(out) = D-glucose(in) (RHEA:60376)
subunit: Found in a complex with ADD2, DMTN and SLC2A1. Interacts (via C-terminus cytoplasmic region) with DMTN. Interacts with SNX27; the interaction is required when endocytosed to prevent degradation in lysosomes and promote recycling to the plasma membrane. Interacts with GIPC (via PDZ domain). Interacts with STOM. Interacts with SGTA (via Gln-rich region) (By similarity). Interacts with BSG (By similarity). Interacts with SMIM43; the interaction may promote SLC2A1-mediated glucose transport to meet the energy needs of mesendoderm differentiation (By similarity). - Glucose transporter expression differs between bovine monocyte and macrophage subsets and is influenced by milk production.
Eger, Journal of dairy science 2016 (PubMed)- GeneRIF: Low GLUT1 and GLUT3 expression in nonclassical monocytes was unaltered during differentiation into macrophages. GLUT4 mRNA was only detectable in unstimulated macrophages. Neither monocytes nor macrophages were insulin responsive.
- Glucose transporter and hypoxia-associated gene expression in the mammary gland of transition dairy cattle.
Mattmiller, Journal of dairy science 2011 (PubMed)- GeneRIF: Significant increases in GLUT1 gene expression were observed during early lactation.
- GLUT-1 glucose transporters in the blood-brain barrier: differential phosphorylation.
Devraj, Journal of neuroscience research 2011 - GeneRIF: the different conformations of the GLUT-1 transporter in luminal (blood facing) and abluminal (brain facing) membranes of bovine cerebral endothelial cells arise from differential phosphorylation of GLUT-1
- Hyperthermia-induced Hsp90·eNOS preserves mitochondrial respiration in hyperglycemic endothelial cells by down-regulating Glut-1 and up-regulating G6PD activity.
Presley, The Journal of biological chemistry 2010 - GeneRIF: Hyperthermia-induced Hsp90.eNOS preserves mitochondrial respiration in hyperglycemic endothelial cells by down-regulating Glut-1 and up-regulating G6PD activity.
- Human T cell leukemia virus envelope binding and virus entry are mediated by distinct domains of the glucose transporter GLUT1.
Manel, The Journal of biological chemistry 2005 (PubMed)- GeneRIF: distinct domains of the glucose transporter GLUT1 mediate HTLV envelope binding and virus entry
- Distinct regulation of glucose transport and GLUT1/GLUT3 transporters by glucose deprivation and IGF-I in chromaffin cells.
Fladeby, Biochimica et biophysica acta 2003 (PubMed)- GeneRIF: distinct regulation by glucose deprivation in chromaffin cells
- Expression profiling of glucose transporter 1 (GLUT1) and apoptotic genes (BAX and BCL2) in milk enriched mammary epithelial cells (MEC) in riverine buffalo during lactation.
Yadav, Animal biotechnology 2014 (PubMed)- GeneRIF: Milk enriched mammary epithelial cells were used to study the expression pattern of GLUT1 and apoptotic genes (BAX and BCL2) across different stages of lactation in riverine buffalo in relation to milk yield.
GTR1_MOUSE / P17809 Solute carrier family 2, facilitated glucose transporter member 1; Glucose transporter type 1, erythrocyte/brain; GLUT-1; GT1 from Mus musculus (Mouse) (see 7 papers)
NP_035530 solute carrier family 2, facilitated glucose transporter member 1 isoform 1 from Mus musculus
33% identity, 90% coverage
- function: Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake (PubMed:17320047, PubMed:35810171). Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses (By similarity). Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain (By similarity). In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors (By similarity). Required for mesendoderm differentiation (PubMed:35810171).
catalytic activity: D-glucose(out) = D-glucose(in) (RHEA:60376)
subunit: Found in a complex with ADD2, DMTN and SLC2A1. Interacts (via C-terminus cytoplasmic region) with DMTN isoform 2. Interacts with SNX27; the interaction is required when endocytosed to prevent degradation in lysosomes and promote recycling to the plasma membrane. Interacts with GIPC (via PDZ domain). Interacts with STOM. Interacts with SGTA (via Gln-rich region) (By similarity). Interacts with isoform 1 of BSG (By similarity). Interacts with SMIM43; the interaction may promote SLC2A1-mediated glucose transport to meet the energy needs of mesendoderm differentiation (PubMed:35810171).
disruption phenotype: Early embryonic lethality. - Extracellular Vesicles Secreted by Mouse Decidual Cells Carry Critical Information for the Establishment of Pregnancy
Ma, Endocrinology 2022 - “...cell death protein 6 0.00E+00 6.94E+05 UD Slc2a1 P17809 Solute carrier family 2, facilitated glucose transporter member 1 0.00E+00 3.26E+05 UD Igfbp7 F8WH23...”
- SWATH-Based Comprehensive Determination of the Localization of Apical and Basolateral Membrane Proteins Using Mouse Liver as a Model Tissue.
Hirano, Biomedicines 2022 - “...B2RX12 1.71 0.00 Yes Numb Q9QZS3 1.82 0.01 Yes Dnm2 P39054 1.74 0.02 Potentially Slc2a1 P17809 1.59 0.05 Yes Vapa Q9WV55 1.77 0.03 Yes Ap2m1 P84091 1.68 0.01 Yes Stx4 P70452 1.76 0.01 Yes Ap2a2 P17427 1.66 0.00 Yes Enzymes Efr3a Q8BG67 1.74 0.01 Yes Ap2s1...”
- Efficient isolation of brain capillary from a single frozen mouse brain for protein expression analysis.
Ogata, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2021 - PAX2 promotes epithelial ovarian cancer progression involving fatty acid metabolic reprogramming.
Feng, International journal of oncology 2020 - “...Protein accession no. Gene Protein description RM-PAX2 RM-WPI ratio Regulated type P - value Glycolysis P17809 Slc2a1, Glut-1, Glut1 Solute carrier family 2, facilitated glucose transporter member 1 0.86 - 0.3308 P17710 Hk1 Hexokinase-1 0.91 - 0.1620 O08528 Hk2 Hexokinase-2 0.83 - 0.2196 Q3TRM8 Hk3 Hexokinase-3...”
- MS/MS in silico subtraction-based proteomic profiling as an approach to facilitate disease gene discovery: application to lens development and cataract.
Aryal, Human genetics 2020 - “...Q9WUB3 Glycogen phosphorylase, muscle form None found 59 Nedd8 P29595 NEDD8 None found 60 Slc2a1 P17809 Solute carrier family 2, facilitated glucose transporter member 1 None found 61 Sf3b5 Q923D4 Splicing factor 3B subunit 5 (SF3b5) None found 62 Kif1a P33173 Kinesin-like protein KIF1A None found...”
- “...4.0 16.5 3.0E-93 0.00000 97.9 5.9 Cadm1 Q8R5M8 3.5 11.9 5.0E-31 0.00000 28.8 2.4 Slc2a1 P17809 3.1 9.5 1.0E-10 0.00000 11.5 1.2 Arvcf P98203 3.0 8.4 4.0E-19 0.00000 21.3 2.5 Tjp1 P39447 2.9 7.6 1.0E-41 0.00000 47.9 6.3 Ezr P26040 2.8 7.1 3.0E-70 0.00000 108.9 15.3...”
- Alport syndrome: Proteomic analysis identifies early molecular pathway alterations in Col4a3 knock out mice.
Nicolaou, Nephrology (Carlton, Vic.) 2020 - “...MM Glutathione Stransferase Mu 2 P52825 CPT2 4.34E02 0.5 NN MM Carnitine Opalmitoyltransferase 2, mitochondrial P17809 GTR1 2.83E03 0.5 NN MM Solute carrier family 2, facilitated glucose transporter member 1 O70133 DHX9 1.61E03 0.5 NN MM ATPdependent RNA helicase A O88322 NID2 4.49E03 0.5 NN MM...”
- Label-free quantitative mass spectrometry analysis of differential protein expression in the developing cochlear sensory epithelium
Darville, Proteome science 2018 - “...normalized spectral countsS.D. P62631 Elongation factor 1-alpha 2 20.79.79 Q6GQT1 Alpha-2-macroglobulin-P 11.54.54 P19221 Prothrombin 10.76.05 P17809 Acyl-CoA synthetase long-chain family member 6 9.408.54 Q5ICG5 Solute carrier family 2, facilitated glucose transporter member 1 8.408.77 P22599 Alpha-1-antitrypsin 12 5.804.88 Q99K67 Alpha-aminoadipic semialdehyde synthase 4.503.79 P00920 Carbonic anhydrase...”
- Native KCC2 interactome reveals PACSIN1 as a critical regulator of synaptic inhibition
Mahadevan, eLife 2017 - “...1 X JAGN1 Q5XKN4 12.0 1 X PPFIA3 P60469 11.0 1 X X X SLC2A1 P17809 11.0 0.96 X YWHAE P62259 10.0 0.99 X X X X X ACTN4 P57780 9.0 1 X X CRMP1 P97427 8.0 1 X X X X PITPNM2 Q6ZPQ6 8.0 1...”
- More
- GLUT1 regulates the release of VEGF-A in the alveolar epithelium of lipopolysaccharide-induced acute lung injury.
Liang, Cell biology international 2024 (PubMed)- GeneRIF: GLUT1 regulates the release of VEGF-A in the alveolar epithelium of lipopolysaccharide-induced acute lung injury.
- GLUT1 mediates the release of HMGB1 from airway epithelial cells in mixed granulocytic asthma.
Tang, Biochimica et biophysica acta. Molecular basis of disease 2024 (PubMed)- GeneRIF: GLUT1 mediates the release of HMGB1 from airway epithelial cells in mixed granulocytic asthma.
- GLUT1-mediated glucose import in B cells is critical for anaplerotic balance and humoral immunity.
Bierling, Cell reports 2024 (PubMed)- GeneRIF: GLUT1-mediated glucose import in B cells is critical for anaplerotic balance and humoral immunity.
- Expression of the monocarboxylate transporter MCT1 is required for virus-specific mouse CD8+ T cell memory development.
D'Aria, Proceedings of the National Academy of Sciences of the United States of America 2024 - GeneRIF: Expression of the monocarboxylate transporter MCT1 is required for virus-specific mouse CD8[+] T cell memory development.
- GLUT1 Promotes NLRP3 Inflammasome Activation of Airway Epithelium in Lipopolysaccharide-Induced Acute Lung Injury.
Li, The American journal of pathology 2024 (PubMed)- GeneRIF: GLUT1 Promotes NLRP3 Inflammasome Activation of Airway Epithelium in Lipopolysaccharide-Induced Acute Lung Injury.
- GLUT1 overexpression enhances CAR T cell metabolic fitness and anti-tumor efficacy.
Shi, Molecular therapy : the journal of the American Society of Gene Therapy 2024 - GeneRIF: GLUT1 overexpression enhances CAR T cell metabolic fitness and anti-tumor efficacy.
- Astrocytic GLUT1 reduction paradoxically improves central and peripheral glucose homeostasis.
Ardanaz, Science advances 2024 - GeneRIF: Astrocytic GLUT1 reduction paradoxically improves central and peripheral glucose homeostasis.
- GLUT1 is redundant in hypoxic and glycolytic nucleus pulposus cells of the intervertebral disc.
Johnston, JCI insight 2023 - GeneRIF: GLUT1 is redundant in hypoxic and glycolytic nucleus pulposus cells of the intervertebral disc.
- More
R0K3X3 Solute carrier family 2, facilitated glucose transporter member 5 (Fragment) from Anas platyrhynchos
32% identity, 89% coverage
- A comparative proteomic study of high and low semen quality seminal plasma in drakes.
Tang, Poultry science 2022 - “...PPI ) network analysis, eight potential candidate proteins were identified, including P19140 (Alpha-enolase), R0KUV7 (Calreticulin), R0K3X3 (Solute carrier family 2, facilitated glucose transporter member 5), R0L6V0 (Proteasome subunit beta), R0JKW0 (Cytochrome c), R0JMC5 (Tubulin alpha chain), R0LCK1 (Cathepsin C), and R0JUP6 (Cathepsin D), which could play...”
- “...nodes and 67 edges. The top highest degree proteins included P19140 (Alpha-enolase), R0KUV7 (Calreticulin), and R0K3X3 (Solute carrier family 2, facilitated glucose transporter member 5) ( Figure 4 B) . P19140 (Alpha-enolase) (Degree=15) showed higher degrees of connection degrees than other DEPs and was considered core...”
CNAG_06521 hypothetical protein from Cryptococcus neoformans var. grubii H99
32% identity, 83% coverage
K9H0P1 MFS monosaccharide transporter, putative from Penicillium digitatum (strain Pd1 / CECT 20795)
30% identity, 83% coverage
O62787 Solute carrier family 2, facilitated glucose transporter member 3 from Sus scrofa
33% identity, 87% coverage
- GPX5-Enriched Exosomes Improve Sperm Quality and Fertilization Ability.
Huang, International journal of molecular sciences 2024 - “...Accession Protein Name Fold of Change (HCR/LCR) p -Value O18994 Glutathione peroxidase 5 4.14 0.0094 O62787 Glucose transporter type 3 3.46 0.0141 O97763 Niemann Pick type C2 protein homolog 2.01 0.0010 P00336 L-lactate dehydrogenase B chain 4.50 0.0340 P00339 L-lactate dehydrogenase A chain isoform X3 2.62...”
GTR3_SHEEP / P47843 Solute carrier family 2, facilitated glucose transporter member 3; Glucose transporter type 3, brain; GLUT-3 from Ovis aries (Sheep) (see paper)
NP_001009770 solute carrier family 2, facilitated glucose transporter member 3 from Ovis aries
32% identity, 87% coverage
- function: Facilitative glucose transporter. Can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport. Required for mesendoderm differentiation (By similarity).
catalytic activity: D-glucose(out) = D-glucose(in) (RHEA:60376)
catalytic activity: D-galactose(in) = D-galactose(out) (RHEA:34915)
subunit: Interacts with SMIM43; the interaction may promote SLC2A3- mediated glucose transport to meet the energy needs of mesendoderm differentiation. - iTRAQ-Based Identification of Proteins Related to Muscle Growth in the Pacific Abalone, Haliotis discus hannai.
Huang, International journal of molecular sciences 2017 - “...A1, actin-2, actin, solute carrier family 2 facilitated glucose transporter member 3 (SLC2A3; Accession Number: P47843) ACTB, GDPD1 Endometrial cancer - kitasatospora griseola strain MF730-N6 RKJC_4, EGFR, GDPD1 Shigellosis actin A1, actin-2, actin profilin (Accession Number: F4XXT7), ACTB, GDPD1 Regulation of actin cytoskeleton actin A1, actin-2,...”
- Production and release of antimicrobial and immune defense proteins by mammary epithelial cells following Streptococcus uberis infection of sheep
Addis, Infection and immunity 2013 - “...Q258K2 P28783 Q1JPB0 P20000 P20700 Q8SPQ0 P27214 O46522 P47843 Integrin beta-2 Myeloperoxidase Annexin A3 Vimentin Filamin A Coronin 1A Myosin 9 Protein S100A9...”
- Impact of Placental SLC2A3 Deficiency during the First-Half of Gestation.
Lynch, International journal of molecular sciences 2022 - GeneRIF: Impact of Placental SLC2A3 Deficiency during the First-Half of Gestation.
NP_001034897 solute carrier family 2, facilitated glucose transporter member 1a from Danio rerio
34% identity, 88% coverage
GTR3_RAT / Q07647 Solute carrier family 2, facilitated glucose transporter member 3; Glucose transporter type 3, brain; GLUT-3 from Rattus norvegicus (Rat) (see 3 papers)
TC 2.A.1.1.12 / Q07647 Glucose uniporter, Glut3 (also transports dehydro-ascorbate; Maulén et al., 2003). Down-regulated in the brains of Alzheimer's disease patients (Liu et al., 2008b) from Rattus norvegicus (Rat) (see 2 papers)
32% identity, 90% coverage
- function: Facilitative glucose transporter. Can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport. Required for mesendoderm differentiation (By similarity).
catalytic activity: D-glucose(out) = D-glucose(in) (RHEA:60376)
catalytic activity: D-galactose(in) = D-galactose(out) (RHEA:34915)
subunit: Interacts with SMIM43; the interaction may promote SLC2A3- mediated glucose transport to meet the energy needs of mesendoderm differentiation. - substrates: glucose
tcdb comment: The structure of the human orthologue with D-glucose bound was solved at 1.5 Å resolution in the outward occluded conformation (Deng et al. 2015). Sugars are predominantly coordinated by polar residues in the C-terminal domain. The conformational transition from the outward-open to the outward-occluded states entails a prominent local rearrangement of the extracellular part of TMS 7. Comparison of the outward-facing GLUT3 structures with inward-open GLUT1 provides insight into the alternating access cycle for GLUTs, whereby the C-terminal domain provides the primary substrate-binding site and the N-terminal domain undergoes rigid-body rotation with respect to the C-terminal domain (Deng et al. 2015). Glut3 is involved in several disease states in humans (Lechermeier et al. 2019) - Proteomic investigation of acute and chronic hypoxia/reoxygenation responsive proteins and pathways in H9C2 cardiomyoblasts
Öztuğ, Turkish journal of biology = Turk biyoloji dergisi 2024 - “...alpha 1.56564E-16 O55043 Rho guanine nucleotide exchange factor 7 1.69661E-06 Q63433 Serine/threonine-protein kinase N1 8.76119E-12 Q07647 Solute carrier family 2, facilitated glucose transporter member 3 6.61577E-08 Q2M2R8 Peroxisomal targeting signal 1 receptor 4.86371E-05 Q9Z2J4 Nexilin 1.56564E-16 Q7TP54 Rho family-interacting cell polarization regulator 2 1.1613E-06 D4ACN8 Plasminogen...”
- Major facilitator superfamily
Pao, Microbiology and molecular biology reviews : MMBR 1998 - “...P11168 P14246 P12336 P47842 P28568 P11169 P32037 P47843 Q07647 P14672 P14142 P19357 P22732 P46408 P43427 Q00712 B30310 U39197 U29377 U43375 U52842 Z46381 L27651...”
- “...P37021 P09830 P09098 P21906 P43581 P13181 P11636 P30605 P07921 P15685 S59368 Q07647 U11843 P15686 Q02563 X78855 Q06222 SP SP SP SP SP SP SP SP SP SP PIR SP GB...”
NP_777028 solute carrier family 2, facilitated glucose transporter member 3 from Bos taurus
32% identity, 87% coverage
XP_011536149 proton myo-inositol cotransporter isoform X1 from Homo sapiens
30% identity, 72% coverage
- The genetic variants in calcium signaling related genes influence anti-tuberculosis drug induced liver injury: A prospective study.
Lyu, Medicine 2019 - GeneRIF: Our study revealed that both BDKRB2 and TENM2 genetic polymorphisms were interrogated in relation to anti-tuberculosis drug induced liver injury (ATDILI) susceptibility and some laboratory indicators in the Western Chinese Han population, shedding a new light on exploring novel biomarkers and targets for ATDILI.
- Proton myo-inositol cotransporter is a novel γ-secretase associated protein that regulates Aβ production without affecting Notch cleavage.
Teranishi, The FEBS journal 2015 (PubMed)- GeneRIF: SLC2A13 is a novel gamma-secretase associated protein that regulates amyloid beta production without affecting Notch cleavage.
- Identification of genes associated with non-small-cell lung cancer promotion and progression.
Bankovic, Lung cancer (Amsterdam, Netherlands) 2010 (PubMed)- GeneRIF: genetic alterations of TSPAN14, SLC2A13 and PHF20 could play a role in non-small-cell lung cancer promotion
- Evaluation of expression and function of the H+/myo-inositol transporter HMIT.
Di, BMC cell biology 2009 - GeneRIF: HMIT is primarily a neuronal transporter widely expressed in the rat and human brain, with particularly high levels in the hippocampus and cortex, as shown by immunohistochemistry.
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose, Molecular medicine (Cambridge, Mass.) - GeneRIF: Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
- The Solute Carrier Family 2 Genes Are Potential Prognostic Biomarkers in Acute Myeloid Leukemia.
Lai, Technology in cancer research & treatment - GeneRIF: The Solute Carrier Family 2 Genes Are Potential Prognostic Biomarkers in Acute Myeloid Leukemia.
GTR3_RABIT / Q9XSC2 Solute carrier family 2, facilitated glucose transporter member 3; Glucose transporter type 3, brain; GLUT-3 from Oryctolagus cuniculus (Rabbit) (see paper)
32% identity, 89% coverage
- function: Facilitative glucose transporter. Can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport. Required for mesendoderm differentiation (By similarity).
catalytic activity: D-glucose(out) = D-glucose(in) (RHEA:60376)
catalytic activity: D-galactose(in) = D-galactose(out) (RHEA:34915)
subunit: Interacts with SMIM43; the interaction may promote SLC2A3- mediated glucose transport to meet the energy needs of mesendoderm differentiation.
AO090010000488 No description from Aspergillus oryzae RIB40
33% identity, 86% coverage
Ga0059261_1777 D-fructose transporter, sugar porter family from Sphingomonas koreensis DSMZ 15582
33% identity, 91% coverage
- mutant phenotype: Specific phenotype on fructose and raffinose; during growth on raffinose, it is probably cleaved to sucrose in the periplasm (by Ga0059261_1166), so this probably is important on raffinose because of the fructose uptake
FVEG_02081 hypothetical protein from Fusarium verticillioides 7600
31% identity, 84% coverage
- Involvement of FST1 from Fusarium verticillioides in virulence and transport of inositol
Niu, Molecular plant pathology 2017 (secret) - Transcriptome changes in Fusarium verticillioides caused by mutation in the transporter-like gene FST1
Niu, BMC microbiology 2015 - “...genome with the yeast ITR1p sequence identified eight genes with high sequence similarity (FVEG_01519, FVEG_01638, FVEG_02081, FVEG_03992, FVEG_06504, FVEG_07757, FVEG_11293, and FVEG_12687). The sequence of FST1 was not identified by the search. Among the eight identified genes, expression was significantly down-regulated in fst1 for FVEG_06504 (named...”
Q59GX2 Solute carrier family 2, facilitated glucose transporter member 1 (Fragment) from Homo sapiens
32% identity, 85% coverage
- Proteome architecture of human-induced pluripotent stem cell-derived three-dimensional organoids as a tool for early diagnosis of neuronal disorders
Negi, Indian journal of pharmacology 2023 - “...3.793E-03 61 P33240 Cleavage stimulation factor subunit 2 CSTF2 2 60.9 5 1.67 2.576E-02 62 Q59GX2 Solute carrier family 2 (Facilitated glucose transporter) SLC2A1 3 57 6 1.65 5.484E-03 63 Q8NHP8 Putative phospholipase B-like 2 PLBD2 4 65.4 15 1.62 1.496E-02 64 Q1ZYL5 Tropomyosin 1 alpha...”
- Proteomics changes after negative pressure wound therapy in diabetic foot ulcers
Jia, Molecular medicine reports 2021 - “...ATP1B3 0.0047 ko04966 Collecting duct acid secretion E2RVJ0, V9HW21 SLC4A1, HEL-76 0.0065 ko04911 Insulin secretion Q59GX2, P54709 N/A, ATP1B3 0.0109 ko04210 Apoptosis O43236, P02549, P25774 SEPT4, SPTA1, CTSS 0.0133 ko05166 Human T-cell leukemia virus 1 infection Q59GX2, Q9Y277, P27824 N/A, VDAC3, CANX 0.0192 ko05143 African trypanosomiasis...”
- Enhancement of red blood cell transfusion compatibility using CRISPR-mediated erythroblast gene editing.
Hawksworth, EMBO molecular medicine 2018 - “...protein STOM 52 14 102 14 1.35 E7EMK3 Flotillin2 FLOT2 35 15 32 15 0.98 Q59GX2 Solute carrier family 2 (Facilitated glucose transporter) Glut1 SLC2A1 13 9 86 9 1.14 C8C504 Betaglobin HBB 94 21 2,705 1 0.93 P00915 Carbonic anhydrase 1 CA1 72 16 370...”
- Proteomic identification of nuclear processes manipulated by cytomegalovirus early during infection
Carter, Proteomics 2015 - “...7.94E-11 O75182 SIN3B Paired amphipathic helix protein Sin3b 2.44 8.80E-03 2.92E-02 3 3 3.9 8.47E-25 Q59GX2 SLC2A1 Solute carrier family 2 2.40 1.09E-02 3.41E-02 2 2 3.5 2.68E-10 J3QRU1 YES Tyrosine-protein kinase Yes 2.35 3.24E-03 1.40E-02 4 5 8.4 6.52E-11 O00505 KPNA3 Importin subunit alpha-4 2.35...”
- LC/MS-based quantitative proteomic analysis of paraffin-embedded archival melanomas reveals potential proteomic biomarkers associated with metastasis
Huang, PloS one 2009 - “...Q8TBK5 RPL6 60S ribosomal protein L6 2 0.005 Q02878 GAPDHS Glyceraldehyde-3-phosphate dehydrogenase, testis-specific 3 0.006 Q59GX2 GLUT1 Solute carrier family 2, facilitated glucose transporter member 1 2 0.007 Q14568 HSP90AA2 Heat shock protein HSP 90-alpha 2 17 0.008 P07195 LDHB L-lactate dehydrogenase B chain 12 0.008...”
XP_020952567 solute carrier family 2, facilitated glucose transporter member 1 from Sus scrofa
32% identity, 90% coverage
SLC2A1 / P11166 solute carrier family 2, facilitated glucose transporter member 1 from Homo sapiens (see 25 papers)
GTR1_HUMAN / P11166 Solute carrier family 2, facilitated glucose transporter member 1; Glucose transporter type 1, erythrocyte/brain; GLUT-1; HepG2 glucose transporter from Homo sapiens (Human) (see 36 papers)
TC 2.A.1.1.28 / P11166 The erythrocyte/brain hexose facilitator, glucose transporter-1, Gtr1 or Glut1. Transports D-glucose, dehydroascorbate, arsenite and the flavonone, quercetin, via one pathway and water via a distinct channel. Sugar transport has been suggested to function via a sliding mechanism involving several sugar binding sites (Cunningham et al., 2006). Glut1 is the receptor for human T-cell leukemia virus (HTLV)) (Manel et al., 2003). It is regulated by stomatin (TC# 8.A.21) to take up dehydroascorbate (Montel-Hagen et al., 2008). Mutations cause Glut1 deficiency syndrome, a human encephalopathy that results from decreased glucose flux through the blood brain barrier from Homo sapiens (Human) (see 21 papers)
NP_006507 solute carrier family 2, facilitated glucose transporter member 1 from Homo sapiens
32% identity, 90% coverage
- function: Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake (PubMed:10227690, PubMed:10954735, PubMed:18245775, PubMed:19449892, PubMed:25982116, PubMed:27078104, PubMed:32860739). Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses (PubMed:18245775, PubMed:19449892). Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy- independent, facilitative transport of glucose into the brain (PubMed:10227690). In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors (By similarity). Required for mesendoderm differentiation (By similarity).
catalytic activity: D-glucose(out) = D-glucose(in) (RHEA:60376)
subunit: Interacts with GIPC (via PDZ domain) (By similarity). Found in a complex with ADD2, DMTN and SLC2A1. Interacts (via C-terminus cytoplasmic region) with DMTN isoform 2 (PubMed:18347014). Interacts with SNX27; the interaction is required when endocytosed to prevent degradation in lysosomes and promote recycling to the plasma membrane (PubMed:23563491). Interacts with STOM (PubMed:23219802). Interacts with SGTA (via Gln-rich region) (By similarity). Interacts with isoform 1 of BSG (PubMed:25957687). - substrates: D-glucose, Dehydroascorbate, Quercetin, arsenite
tcdb comment: Mueckler and Makepeace (2009) have presented a model of the exofacial substrate-binding site and helical folding of Glut1. Glut1, 2, 4 and 9 are functional both in the plasma membrane and the endoplasmic reticulum (Takanaga and Frommer, 2010). Glut1 is down-regulated in the brains of Alzheimer's disease patients (Liu et al., 2008b).Metabolic stress rapidly stimulates blood-brain barrier endothelial cell sugar transport by acute up-regulation of plasma membrane GLUT1 levels, possibly involving an AMP-activated kinase activity (Cura and Carruthers, 2010). Serves as a receptor for neuropilin-1 (923aas; 2 TMSs; O14786) and heparan sulfate proteoglycans (HSPGs) (Hoshino, 2012). Glut1 has a nucleotide binding site, and nucleotide binding affects transport activity (Yao and Bajjalieh 2009). The protein serves as a receptor for dermatin and β-adducin which help link the spectrin-actin junctional complex to the erythrocyte plasma membrane (Khan et al. 2008). May play a role in paroxysmal dyskinesias (Erro et al. 2017). GLUT1 mediates infection of CD4+ lymphocytes by human T cell leukemia virus type 1 (Jin et al. 2006). Mutations in disordered regions can cause disease by introducing dileucine motifs, For example, mutations that are causative of GLUT1 deficiency syndrome are of this type and the mutated protein mislocalizes to intracellular compartments (Meyer et al. 2018). Glucose transits along a transmembrane pathway through significant rotational motions while maintaining hydrogen bonds with the protein (Galochkina et al. 2019). It is phosphoryated by protein kinase C-B (TC# 8.A.104.1.4) (Lee et al. 2015). GLUT1-mediated exchange of fluorosugars has been studied (Shishmarev et al. 2018) - Insulin signaling and pharmacology in humans and in corals
Murthy, PeerJ 2024 - “...(2017) Ohira et al. (2005) GLUT1 Solute carrier family 2, facilitated glucose transporter member 1 P11166 (GTR1_HUMAN) Mueckler & Makepeace (2008) GLUT4 Solute carrier family 2, facilitated glucose transporter member 4 P14672 (GLUT4_HUMAN) Kawanishi et al. (2000) GRB2 Growth factor receptor-bound protein 2 P62993 (GRB2_HUMAN) Lowenstein...”
- “...Q14409 Glycerol kinase 3 553 pdam_00006960 100 1.00E46 2.50E50 424 11468 8476 (476) 18 GLUT1 P11166 Solute carrier family 2, facilitated glucose transporter member 1 492 pdam_00006372 100 1.40E40 4.10E44 445 15470 40484 (495) 45 GLUT4 P14672 Solute carrier family 2, facilitated glucose transporter member 4...”
- Endoplasmic Reticulum Stress in Bronchopulmonary Dysplasia: Contributor or Consequence?
Wu, Cells 2024 - CavitOmiX Drug Discovery: Engineering Antivirals with Enhanced Spectrum and Reduced Side Effects for Arboviral Diseases.
Parigger, Viruses 2024 - “...major clusters at a distance threshold of 1.4 ( Figure 4 ). The cluster representatives, P11166, Q14376 and Q96J66, refer to the glucose transporter SLC2A1, the UDP-glucose 4-epimerase GALE and the ATP-binding cassette member ABCC11, respectively, and are highlighted in bold in Figure 4 . Figure...”
- “...which still show different protein folds, and (ii) the representatives of the three major clusters, P11166, Q14376 and Q96J66, together with Q460N5, which comprises the most similar binding site to that of nsP3. 3.3. Identification of Concerning Viral Variants For the design of effective antivirals, continuous...”
- Strictosamide promotes wound healing through activation of the PI3K/AKT pathway.
Ming, Heliyon 2024 - “...IX alpha subunit SCN9A Q15858 NAD-dependent deacetylasesirtuin 2 SIRT2 Q8IXJ6 Glucose transporter (by homology) SLC2A1 P11166 Tyrosine-protein kinase SYK SYK P43405 DNA topoisomerase I TOP1 P11387 Fig. 7 Screening of STR and wound healing hub genes. (A). Venn diagram of the STR and the wound healing-related...”
- The Plasmodium vivax MSP1P-19 is involved in binding of reticulocytes through interactions with the membrane proteins band3 and CD71.
Zuo, The Journal of biological chemistry 2024 - “...Ankyrin1 P16157 7.6 206.1 9 4 Solute carrier family 2, facilitated glucose transporter member 1 P11166 4.33 54.1 2 5 55kDa erythrocyte membrane protein Q00013 5.35 52.3 2 6 Protein band 4.2 P16452 1.88 77.0 1 Extracellular loop 5 of band3 serves as a critical binding...”
- Dual inhibitory potential of ganoderic acid A on GLUT1/3: computational and in vitro insights into targeting glucose metabolism in human lung cancer.
Bashir, RSC advances 2024 - “...employed. The protein sequences for GLUT1 and GLUT3 were obtained from UniProt with the IDs P11166 and P11169, respectively, for this investigation. The outward-open conformation of GLUT3 protein structure labeled with PDB ID: 4ZW9 has a resolution of 1.5 and contains a single mutation (N43T). 27...”
- Surfaceome Profiling of Cell Lines and Patient-Derived Xenografts Confirm FGFR4, NCAM1, CD276, and Highlight AGRL2, JAM3, and L1CAM as Surface Targets for Rhabdomyosarcoma
Timpanaro, International journal of molecular sciences 2023 - “...PE = 1 SV = 1 2.61 10 8 4.10 10 8 0.652 18 77 P11166 SLC2A1 Solute carrier family 2, facilitated glucose transporter member 1 OS = Homo sapiens OX = 9606 GN = SLC2A1 PE = 1 SV = 2 3.30 10 8 3.01...”
- Identification of Candidate Biomarkers of Alzheimer's Disease via Multiplex Cerebrospinal Fluid and Serum Proteomics
Liu, International journal of molecular sciences 2023 - “...Immunoglobulin delta heavy chain IGD 3.06 10 55 P10124 Serglycin SRGN SRGN 1.95 10 49 P11166 Solute carrier family 2, facilitated glucose transporter member 1 GTR1 SLC2A1 0.00029 P27105 Stomatin STOM STOM 4.1 10 101 Q14CN4 Keratin, type II cytoskeletal 72 K2C72 KRT72 0.00112 Q5THR3 EF-hand...”
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- Human umbilical cord mesenchymal stem cell-derived exosomal miR-214-3p regulates the progression of gallbladder cancer by regulating ACLY/GLUT1.
Liu, Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2024 (PubMed)- GeneRIF: Human umbilical cord mesenchymal stem cell-derived exosomal miR-214-3p regulates the progression of gallbladder cancer by regulating ACLY/GLUT1.
- Gene expression of protein kinase AMP-activated catalytic subunit alpha 1 (PRKAA1), solute carrier family 2 member 1 (SLC2A1) and mechanistic target of rapamycin (MTOR) in metformin-treated type 2 diabetes patients with COVID-19: impact on inflammation markers.
Petakh, Inflammopharmacology 2024 (PubMed)- GeneRIF: Gene expression of protein kinase AMP-activated catalytic subunit alpha 1 (PRKAA1), solute carrier family 2 member 1 (SLC2A1) and mechanistic target of rapamycin (MTOR) in metformin-treated type 2 diabetes patients with COVID-19: impact on inflammation markers.
- Inhibition of glycolysis and SIRT1/GLUT1 signaling ameliorates the apoptotic effect of Leptosidin in prostate cancer cells.
Park, Phytotherapy research : PTR 2024 (PubMed)- GeneRIF: Inhibition of glycolysis and SIRT1/GLUT1 signaling ameliorates the apoptotic effect of Leptosidin in prostate cancer cells.
- GLUT1 mediates the release of HMGB1 from airway epithelial cells in mixed granulocytic asthma.
Tang, Biochimica et biophysica acta. Molecular basis of disease 2024 (PubMed)- GeneRIF: GLUT1 mediates the release of HMGB1 from airway epithelial cells in mixed granulocytic asthma.
- BRIX1 promotes ribosome synthesis and enhances glycolysis by selected translation of GLUT1 in colorectal cancer.
Jiang, The journal of gene medicine 2024 (PubMed)- GeneRIF: BRIX1 promotes ribosome synthesis and enhances glycolysis by selected translation of GLUT1 in colorectal cancer.
- HNRNPC Regulates GLUT1/LDHA Pathway by Stabilizing FOXM1 mRNA to Promote the Progression and Aerobic Glycolysis of Multiple Myeloma.
Wu, Annals of clinical and laboratory science 2024 (PubMed)- GeneRIF: HNRNPC Regulates GLUT1/LDHA Pathway by Stabilizing FOXM1 mRNA to Promote the Progression and Aerobic Glycolysis of Multiple Myeloma.
- Ubiquitin-specific protease 54 regulates GLUT1-mediated aerobic glycolysis to inhibit lung adenocarcinoma progression by modifying p53 degradation.
Chen, Oncogene 2024 (PubMed)- GeneRIF: Ubiquitin-specific protease 54 regulates GLUT1-mediated aerobic glycolysis to inhibit lung adenocarcinoma progression by modifying p53 degradation.
- PURA and GLUT1: Sweet partners for brain health.
Colombo, Biochimica et biophysica acta. Molecular basis of disease 2024 (PubMed)- GeneRIF: PURA and GLUT1: Sweet partners for brain health.
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AT1G05030 hexose transporter, putative from Arabidopsis thaliana
34% identity, 82% coverage
- Genetic association analysis in sugarcane (Saccharum spp.) for sucrose accumulation in humid environments in Colombia
Saavedra-Díaz, BMC plant biology 2024 - “...and monosaccharide transporters (MSTs) [ 69 ]. For early maturity, MST2, the plastidic glucose transporter At1g05030, and SUT4 were found within the LD region of the markers 1_33380771, 2_29103764, and 4_55115204, respectively (Table 5 ). At normal maturity, the candidate genes monosaccharide-sensing protein 2 MSSP2, polyol...”
- “...maturations, close to the candidate genes MST and ERD6-like respectively. The genes MST1, MST2, GTP2, At1g05030, and PLT5, are all directly involved in the transport of monosaccharides, required compounds for various processes of plant growth, development [ 68 ], and osmotic adjustments (e.g., monosaccharide homeostasis) [...”
- The novel chloroplast glucose transporter pGlcT2 affects adaptation to extended light periods
Valifard, The Journal of biological chemistry 2023 - “...( 3 ). The next homolog to pGlcT is the protein encoded by the gene At1g05030 . In contrast to pGlcT, no report on the protein encoded by the gene At1g05030 , hereafter referred to as pGlcT2, is available. However, an in-depth characterization of pGlcT2 properties...”
- “...). The structurally closest homolog to pGlcT is the putative carrier encoded by the gene At1g05030 , which we named pGlcT2 ( Fig.S1 ). The molecular architecture of pGlcT2 demonstrates that this protein is comprised of 524 amino acids and exhibits 12 predicted transmembrane domains (TM)...”
- Comparative transcriptome analysis reveals the phosphate starvation alleviation mechanism of phosphate accumulating Pseudomonas putida in Arabidopsis thaliana
Srivastava, Scientific reports 2023 - “...) were upregulated in both RAR and HA+RAR treatments. Genes associated with carbohydrate metabolism ( At1g05030 ), jasmonic acid LOX2 ( At3g45140 ), glutathione-s-transferase ( At5g17220 ), and ethylene biosynthesis ( At4g26200 ) showed upregulation in HA and HA+RAR treatment. However, these genes were either downregulated...”
- “...0.907445 1.36474 AT1G21250 WAK1 0.320022 3.180495 1.194565 AT3G45140 jasmonic acid (JA) LOX2 1.612366 1.81294 1.884971 AT1G05030 Carbohydrate metabolism 0.174888 0.33848 0.290582 AT1G06730 Plastid nucleoside kinase 0.123424 0.08761 0.056039 AT1G53730 STRUBBELIG-receptor family 6 0.025972 0.15064 0.160056 AT1G12890 Transcription factor 0.27459 1.217637 0.556539 AT1G01260 Transcription factor 0.140424 0.24861...”
- Genome-Wide Identification and Expression Profiling of Monosaccharide Transporter Genes Associated with High Harvest Index Values in Rapeseed (Brassica napus L.)
Zhang, Genes 2020 - “...whereas the three remaining AtMST genes ( At3G05160 , At1G08890 ( AtERD6-like subfamily ), and At1G05030 ( AtpGlcT subfamily )) lacked homologs in B. napus ( Table 2 ). Detailed information about the BnMST genes is provided in Table S3 . The molecular weights (Mw) of...”
- Gene expression profiling through microarray analysis in Arabidopsis thaliana colonized by Pseudomonas putida MTCC5279, a plant growth promoting rhizobacterium
Srivastava, Plant signaling & behavior 2012 - “...traits such as carbohydrate metabolism (At1g05030, 5.71-fold), nucleoside transferase (At1g63730, 6.59-fold), kinases (At1g06730, 5.32-fold; At1g53730,...”
- Reduced expression of a gene encoding a Golgi localized monosaccharide transporter (OsGMST1) confers hypersensitivity to salt in rice (Oryza sativa)
Cao, Journal of experimental botany 2011 - “...sequence is compared with OsMST1-8, Os09g23110, OspGlcT, and OsTMT1-4 from Oryza sativa , AtSGB1, At1g67300, At1g05030, and AtpGlcT from Arabidopsis thaliana , ScRGT2 from Saccharomyces cerevisiae , HsSLC2A3 from Homo sapiens , NtpGlcT from Nicotiana tabacum, and ZmpGlcT from Zea mays . (C) OsGMST1 is a...”
- “...shows that the putative Arabidopsis paralogues to OsGMST1 are encoded by At1g67300 , SGB1 , At1g05030 , and AtpGlcT and the proteins have 67%, 65%, 44%, and 43% identity to OsGMST1, respectively. These four MST proteins are in the pGlcT subfamily ( Buttner, 2007 ). SGB1...”
- Physical Mapping in a Triplicated Genome: Mapping the Downy Mildew Resistance Locus Pp523 in Brassica oleracea L
Carlier, G3 (Bethesda, Md.) 2011 - “...Not Seq PCR C5 53O21 At1g02660 NS PCR C8a 114F8 NS At1g06590 PCR C8a 19M3 At1g05030 At1g05230 Map F C5 6D7 NS At1g02270 Map F C8a 11A22 At1g06680 NS PCR C8a 89C6 At1g05577 At1g05690 PCR C5 92O1 NS At1g02990 PCR C8a 38E20 At1g06490 NS PCR C8a...”
- The Vitis vinifera sugar transporter gene family: phylogenetic overview and macroarray expression profiling
Afoufa-Bastien, BMC plant biology 2010 - “...putative transporters could be localized in Golgi apparatus. Finally Vv25939001 forms a third group with At1g05030. Search for cis -elements putatively involved in the transcriptional regulation of sugar transporter genes We have identified a 2 kb promoter region for each of the 29 fully sequenced genes...”
TC 2.A.1.1.45 / Q8L6Z8 Vacuolar (tonoplast) glucose transporter1, Vgt1 (important for seed germination and flowering) from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
RF|NP_186959.2 D-xylose-proton symporter-like 1 from Arabidopsis thaliana
NP_186959 vacuolar glucose transporter 1 from Arabidopsis thaliana
AT3G03090 AtVGT1 (Arabidopsis thaliana vacuolar glucose transporter 1); carbohydrate transmembrane transporter/ fructose transmembrane transporter/ glucose transmembrane transporter/ sugar:hydrogen symporter from Arabidopsis thaliana
32% identity, 85% coverage
- substrates: glucose
- Identification and functional expression of the Arabidopsis thaliana vacuolar glucose transporter 1 and its role in seed germination and flowering.
Aluri, Proceedings of the National Academy of Sciences of the United States of America 2007 - GeneRIF: Vacuolar glucose transporter 1 (AtVGT1) was localized to the vacuolar membrane. Analyses of Atvgt1 mutant lines indicate an important function of this vacuolar glucose transporter during developmental processes like seed germination and flowering
- Vacuolar Sugar Transporter TMT2 Plays Crucial Roles in Germination and Seedling Development in Arabidopsis
Cao, International journal of molecular sciences 2023 - “...vacuoles in a similar way [ 20 ]. Among the three VGTs, only VGT1 ( At3g03090 ) has been functionally characterized as a vacuolar importer, which transports glucose from the cytoplasm into the vacuoles and plays a vital role in seed germination and flowering [ 20...”
- “...4.13. Accession Numbers We acquired all the Arabidopsis gene sequences from the TAIR database: VGT1 (AT3G03090) , TMT1 (AT1G20840) , TMT2 (AT4G35300) , TMT3 (AT3G51490) , SAUR22 (AT5G18050) , SAUR23 (AT5G18060) , SAUR26 (AT3G03850) , SWEET2 (AT3G14770) , ERDL6 (AT1G75220) , DAO2 (AT1G14120) , PIN6 (AT1G77110)...”
- The novel chloroplast glucose transporter pGlcT2 affects adaptation to extended light periods
Valifard, The Journal of biological chemistry 2023 - “...the distribution pGlcT2 genes in plant species Alignment of pGlcT2 with other sugar transporters (VGT1: At3g03090 , pSUT: At5g59250 , and pGLCT: At5g16150 ) was done using MEGA11 software ( 74 ) based on ClustalW ( 75 ) alignment of the corresponding amino acid sequences. The...”
- Membrane nanodomains and transport functions in plant
Martinière, Plant physiology 2021 - “...transporter (TMT) AT4G35300 (TMT2) Suspension cell cultures Yoshida et al., 2013 Vacuolar glucose transporter (VGT) AT3G03090 (VGT1) Suspension cell cultures Yoshida et al., 2013 Conclusion and prospects A number of proteins transporting molecules such as auxin, water, nitrate, and ammonium across the PM were demonstrated both...”
- Genome-wide identification, expression, and association analysis of the monosaccharide transporter (MST) gene family in peanut (Arachis hypogaea L.)
Wan, 3 Biotech 2020 - “...AhMST17 AtSTP1 (AT1G11260) AhMST13 AhMST13 AhMST9 AtVGT1 (AT3G03090) STP12 (AT4G21480) AtINT4 (AT4G16480) Uptake of extracellular sugars by the embryo and in...”
- “...in pollen and young xylem cells AtVGT1 (AT3G03090) Influences flowering and seed germination AtPLT5/AtPMT5 (AT3G18830) Effect pollen and young xylem cells...”
- A novel eIF4E-interacting protein that forms non-canonical translation initiation complexes
Toribio, Nature plants 2019 - “...used a different statistical model comparison, allowed the additional identification of the glucose transporter VGT1 (At3g03090) 44 as a translationally regulated gene in both ceres mutants compared to Col-0 ( Extended Data Fig. 8 ) (TE fold change -0.779 and -0.829 p-adj 0.017 and 0.049 in...”
- Integrated mRNA and miRNA transcriptome reveal a cross-talk between developing response and hormone signaling for the seed kernels of Siberian apricot
Niu, Scientific reports 2016 - “...Additionally, our mRNA transcriptomic analysis revealed that the homologies of ATVGT1 (sugar transporter family protein, At3g03090), ATK (K + transporter, At4g22200), PGP4 (P-glycoprotein 4, At2g47000), ABCG18 (ABC transporter family protein, At3g55110) and SULTR1;2 (sulfate transporter 1;2, At1g78000) were up-regulated specifically in early-middle stage of developing SASK...”
- Genome-Wide Association Analysis of Adaptation Using Environmentally Predicted Traits
van, PLoS genetics 2015 - “...ATH1 - - 986 - - - AT5G03790 ATHB51 - - - - 1356 1406 AT3G03090 AtVGT1 - - 690 568 1350 - AT2G31650 ATX1 997 1146 890 - - - AT2G33540 CPL3 - 946 - - 949 - AT4G20910 CRM2 - 1436 - - 688...”
- Expression patterns of genes involved in sugar metabolism and accumulation during apple fruit development
Li, PloS one 2012 - “...with MdTMT5 ( Figure 2I ). Both MdvGT1 and MdvGT2 had high homology with AtvGT1 (At3g03090) and AtvGT2 (At5g17010), respectively, and were in the same clade, whereas they had low similarity with AtvGT3 (At5g59250) ( Figure 2J ). Expression of genes in source and sink tissues...”
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P58352 Solute carrier family 2, facilitated glucose transporter member 3 from Bos taurus
32% identity, 87% coverage
GTR3_HUMAN / P11169 Solute carrier family 2, facilitated glucose transporter member 3; Glucose transporter type 3, brain; GLUT-3 from Homo sapiens (Human) (see 6 papers)
TC 2.A.1.1.91 / P11169 Solute carrier family 2, facilitated glucose transporter member 3 (Glucose transporter type 3, brain) (GLUT-3 or GLUT3). It mediates the facilitative uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably dehydroascorbate, but not fructose from Homo sapiens (see 6 papers)
NP_008862 solute carrier family 2, facilitated glucose transporter member 3 from Homo sapiens
31% identity, 86% coverage
- function: Facilitative glucose transporter (PubMed:26176916, PubMed:32860739, PubMed:9477959). Can also mediate the uptake of various other monosaccharides across the cell membrane (PubMed:26176916, PubMed:9477959). Mediates the uptake of glucose, 2- deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate (PubMed:26176916, PubMed:9477959). Does not mediate fructose transport (PubMed:26176916, PubMed:9477959). Required for mesendoderm differentiation (By similarity).
catalytic activity: D-glucose(out) = D-glucose(in) (RHEA:60376)
catalytic activity: D-galactose(in) = D-galactose(out) (RHEA:34915)
subunit: Interacts with SMIM43; the interaction may promote SLC2A3- mediated glucose transport to meet the energy needs of mesendoderm differentiation. - substrates: glucose
tcdb comment: GLUT3, a key neuronal transporter, exhibits multiple intermediate states (Sun and Zheng 2019) - Glut-3 Gene Knockdown as a Potential Strategy to Overcome Glioblastoma Radioresistance.
Pucci, International journal of molecular sciences 2024 - GeneRIF: Glut-3 Gene Knockdown as a Potential Strategy to Overcome Glioblastoma Radioresistance.
- SLC2A3 promotes tumor progression through lactic acid-promoted TGF-β signaling pathway in oral squamous cell carcinoma.
Jiang, PloS one 2024 - GeneRIF: SLC2A3 promotes tumor progression through lactic acid-promoted TGF-beta signaling pathway in oral squamous cell carcinoma.
- The YTHDC1/GLUT3/RNF183 axis forms a positive feedback loop that modulates glucose metabolism and bladder cancer progression.
Yan, Experimental & molecular medicine 2023 - GeneRIF: The YTHDC1/GLUT3/RNF183 axis forms a positive feedback loop that modulates glucose metabolism and bladder cancer progression.
- GLUT3 promotes macrophage signaling and function via RAS-mediated endocytosis in atopic dermatitis and wound healing.
Yu, The Journal of clinical investigation 2023 - GeneRIF: GLUT3 promotes macrophage signaling and function via RAS-mediated endocytosis in atopic dermatitis and wound healing.
- Concurrent presence of diabetes affects the GLUT3 programming of glucose metabolism in glioblastoma.
Kocaeli, European review for medical and pharmacological sciences 2023 (PubMed)- GeneRIF: Concurrent presence of diabetes affects the GLUT3 programming of glucose metabolism in glioblastoma.
- Peritoneal Expression of SGLT-2, GLUT1, and GLUT3 in Peritoneal Dialysis Patients.
Schricker, Kidney & blood pressure research 2022 (PubMed)- GeneRIF: Peritoneal Expression of SGLT-2, GLUT1, and GLUT3 in Peritoneal Dialysis Patients.
- miR-3189-targeted GLUT3 repression by HDAC2 knockdown inhibits glioblastoma tumorigenesis through regulating glucose metabolism and proliferation.
Kwak, Journal of experimental & clinical cancer research : CR 2022 - GeneRIF: miR-3189-targeted GLUT3 repression by HDAC2 knockdown inhibits glioblastoma tumorigenesis through regulating glucose metabolism and proliferation.
- The glucose transporter GLUT3 controls T helper 17 cell responses through glycolytic-epigenetic reprogramming.
Hochrein, Cell metabolism 2022 - GeneRIF: The glucose transporter GLUT3 controls T helper 17 cell responses through glycolytic-epigenetic reprogramming.
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- miR-373 promotes invasion and metastasis of colorectal cancer cells via activating ERK/MAPK pathway
Chen, Scientific reports 2024 - “...R P value Q9BTV4 1.412143144 UP 2.38652E-06 P28360 0.750072908 DOWN 2.34629E-05 P80188 1.349647612 UP 3.29035E-06 P11169 0.782828283 DOWN 2.38279E-05 Q8NDM7 1.347945205 UP 1.51136E-05 P47929 0.80342651 DOWN 0.000158276 Q9Y2Y6 1.661934339 UP 2.82104E-05 Q14533 0.788375559 DOWN 0.004104687 Q96L50 1.572898799 UP 3.46669E-05 Q02410 0.811047389 DOWN 0.004520402 P02787 1.200586725 UP...”
- Comparison of the Amyloid Plaque Proteome in Down Syndrome, Early-Onset Alzheimer's Disease and Late-Onset Alzheimer's Disease.
Martá-Ariza, Research square 2024 - “...P02686 MBP Myelin basic protein 1.97E-06 1.7 P13637 ATP1A3 Sodium/potassium-transporting ATPase subunit alpha-3 1.95E-09 1.6 P11169 SLC2A3 Solute carrier family 2, facilitated glucose transporter member 3 1.97E-06 1.5 P41594 GRM5 Metabotropic glutamate receptor 5 1.45E-07 1.5 Late-onset AD - Plaque vs Non-plaque Uniprot Accession ID Gene...”
- “...1.25E-06 1.6 P20916 MAG Myelin-associated glycoprotein 4.16E-06 1.6 P02686 MBP Myelin basic protein 7.42E-06 1.6 P11169 SLC2A3 Solute carrier family 2, facilitated glucose transporter member 3 3.52E-05 1.5 P13637 ATP1A3 Sodium/potassium-transporting ATPase subunit alpha-3 2.8E-07 1.5...”
- Dual inhibitory potential of ganoderic acid A on GLUT1/3: computational and in vitro insights into targeting glucose metabolism in human lung cancer.
Bashir, RSC advances 2024 - “...protein sequences for GLUT1 and GLUT3 were obtained from UniProt with the IDs P11166 and P11169, respectively, for this investigation. The outward-open conformation of GLUT3 protein structure labeled with PDB ID: 4ZW9 has a resolution of 1.5 and contains a single mutation (N43T). 27 To generate...”
- Overexpression of SERPINA3 suppresses tumor progression by modulating SPOP/NF‑κB in lung cancer
Jin, International journal of oncology 2023 - “...cancer type 2 susceptibility protein 384.202 19.397 0.000 O43791 SPOP Speckle-type POZ 42.132 16.291 0.042 P11169 SLC2A3 Solute carrier family 2, facilitated glucose transporter member 3 53.924 14.177 0.000 Q96PE1 ADGRA2 Adhesion G protein-coupled receptor A2 142.647 7.983 0.018 P41220 RGS2 Regulator of G-protein signaling 2...”
- Magnetic transferrin nanoparticles (MTNs) assay as a novel isolation approach for exosomal biomarkers in neurological diseases
Jang, Biomaterials research 2023 - “...Noelin Y Y Cluster 1 P51149 HUMAN RAB7A Ras-related protein Rab-7a Y N Cluster 2 P11169 HUMAN SLC2A3 Solute carrier family 2, facilitated glucose transporter member 3 Y N Cluster 3 Q66K66 HUMAN TMEM198 Transmembrane protein 198 N Y Cluster 1 P24821 HUMAN TNC Tenascin Y...”
- New findings on the action of hypericin in hypoxic cancer cells with a focus on the modulation of side population cells
Buľková, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 - “...SPRYD4 SPRY domain-containing protein 4 -1,07 0,48 0,003 Q9UHR5 SAP30BP SAP30-binding protein -1,03 0,49 0,006 P11169 SLC2A3 Solute carrier family 2, facilitated glucose transporter member 3 -0,99 0,50 0,009 Q9BQ70 TCF25 Transcription factor 25 -0,95 0,52 0,009 Q13423 NNT NAD(P) transhydrogenase, mitochondrial (MTCH) -0,95 0,52 0,005...”
- Proteomic profiling of extracellular vesicles in synovial fluid and plasma from Oligoarticular Juvenile Idiopathic Arthritis patients reveals novel immunopathogenic biomarkers.
Raggi, Frontiers in immunology 2023 - “...protein MPP1 5.54E+00 -2.99 P10644-2 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 6.44E+00 -3.00 P11169 Solute carrier family 2, facilitated glucose transporter member 3 SLC2A3 4.20E+00 -3.11 Q9NZN3 EH domain-containing protein 3 EHD3 5.35E+00 -3.23 P50148 Guanine nucleotide-binding protein G(q) subunit alpha GNAQ 6.76E+00 -3.38...”
- Defining the proteomic landscape of cultured macrophages and their polarization continuum.
Oates, Immunology and cell biology 2023 - “...CD63 CD63 antigen 1.44 0.60 1.48 P13473 LAMP2 Lysosomeassociated membrane glycoprotein 2 0.36 0.64 1.43 P11169 SLC2A3 Solute carrier family 2, facilitated glucose transporter member 3 0.89 0.61 1.42 P11717 IGF2R Cationindependent mannose6phosphate receptor 1.04 0.48 0.58 Q92542 NCSTN Nicastrin 0.46 0.05 0.52 P48060 GLIPR1 Glioma...”
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TC 2.A.1.1.86 / H9BPB6 The sea bream facilitative glucose transporter 1 (GLUT1) from Sparus aurata
32% identity, 87% coverage
NP_001152798 solute carrier family 2, facilitated glucose transporter member 1 from Canis lupus familiaris
32% identity, 90% coverage
- Histological and immunohistochemical evaluation of stroma variations and their correlation with the Ki-67 index and expressions of glucose transporter 1 and monocarboxylate transporter 1 in canine thyroid C-cell carcinomas.
Kawamura, The Journal of veterinary medical science 2016 - GeneRIF: stroma variations reflect tumor cell proliferation and expressions of GLUT-1 and MCT-1 in canine thyroid C-cell carcinomas
- Hypoxia-Related Marker GLUT-1, CAIX, Proliferative Index and Microvessel Density in Canine Oral Malignant Neoplasia.
Meier, PloS one 2016 - GeneRIF: Hypoxia-Related Marker GLUT-1, CAIX, Proliferative Index and Microvessel Density in Canine Oral Malignant Neoplasia.
- Akita dogs possess GLUT1 in erythrocytes, and Na,K-ATPase activity enables more efficient ascorbic acid recycling.
Ogawa, The Journal of veterinary medical science 2016 - GeneRIF: All Akita dogs had GLUT1 in erythrocyte membranes
- Glucose transporter 1 expression accompanies hypoxia sensing in the cyclic canine corpus luteum.
Papa, Reproduction (Cambridge, England) 2014 (PubMed)- GeneRIF: Our data reveal that the glucose transporter is regulated throughout the corpus luteum lifespan and suggest that the corpus luteum depends on the sensing of hypoxia and the status of luteal vascularisation.
NP_001090886 solute carrier family 2, facilitated glucose transporter member 2 from Sus scrofa
34% identity, 78% coverage
SS1G_06402 hypothetical protein from Sclerotinia sclerotiorum 1980 UF-70
35% identity, 83% coverage
P13355 Solute carrier family 2, facilitated glucose transporter member 1 from Oryctolagus cuniculus
32% identity, 90% coverage
- Major facilitator superfamily
Pao, Microbiology and molecular biology reviews : MMBR 1998 - “...P46501 U28735 U41023 U31961 P27674 P46896 P11166 P17809 P13355 P11167 P20303 S37476 P11168 P14246 P12336 P47842 P28568 P11169 P32037 P47843 Q07647 P14672 P14142...”
P28568 Solute carrier family 2, facilitated glucose transporter member 3 from Gallus gallus
30% identity, 91% coverage
- Major facilitator superfamily
Pao, Microbiology and molecular biology reviews : MMBR 1998 - “...P13355 P11167 P20303 S37476 P11168 P14246 P12336 P47842 P28568 P11169 P32037 P47843 Q07647 P14672 P14142 P19357 P22732 P46408 P43427 Q00712 B30310 U39197 U29377...”
NP_990842 solute carrier family 2, facilitated glucose transporter member 3 from Gallus gallus
30% identity, 91% coverage
FVEG_10988 hypothetical protein from Fusarium verticillioides 7600
31% identity, 82% coverage
Pc21g19770 uncharacterized protein from Penicillium rubens
33% identity, 79% coverage
7sptA / P11169 Crystal structure of exofacial state human glucose transporter glut3 (see paper)
31% identity, 91% coverage
- Ligand: alpha-d-glucopyranose (7sptA)
GTR1_CHICK / P46896 Solute carrier family 2, facilitated glucose transporter member 1; Glucose transporter type 1; GLUT-1; GT1 from Gallus gallus (Chicken) (see paper)
32% identity, 92% coverage
- function: Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain (By similarity). In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors (PubMed:25957687). Required for mesendoderm differentiation (By similarity).
catalytic activity: D-glucose(out) = D-glucose(in) (RHEA:60376)
subunit: Interacts with isoform 1 of BSG. - Embryonic protein undernutrition by albumen removal programs the hepatic amino acid and glucose metabolism during the perinatal period in an avian model
Willems, PloS one 2014 - “...43,9 51 1 3 Cp GLUT1 Solute carrier family 2, facilitated glucose transporter member 1 P46896 8.82 54,1 42 2 1 Cm SMAD3 Mothers against decapentaplegic homolog 3 P84023 6.70 48,3 37 1 3 Cp, Nu LDHB L-lactate dehydrogenase B chain P00337 7.07 36,3 36 1...”
- Major facilitator superfamily
Pao, Microbiology and molecular biology reviews : MMBR 1998 - “...U28737 Z66522 Z66522 P46501 U28735 U41023 U31961 P27674 P46896 P11166 P17809 P13355 P11167 P20303 S37476 P11168 P14246 P12336 P47842 P28568 P11169 P32037 P47843...”
NP_990540 solute carrier family 2, facilitated glucose transporter member 1 from Gallus gallus
32% identity, 90% coverage
- Role of cardiac hypoxia in the pathogenesis of sudden death syndrome in broiler chickens - A metabolic and molecular study.
Safaei, Acta veterinaria Hungarica 2021 (PubMed)- GeneRIF: Role of cardiac hypoxia in the pathogenesis of sudden death syndrome in broiler chickens - A metabolic and molecular study.
- Localisation and function of glucose transporter GLUT1 in chicken (Gallus gallus domesticus) spermatozoa: relationship between ATP production pathways and flagellar motility.
Setiawan, Reproduction, fertility, and development 2020 (PubMed)- GeneRIF: Localisation and function of glucose transporter GLUT1 in chicken (Gallus gallus domesticus) spermatozoa: relationship between ATP production pathways and flagellar motility.
- Insulin acutely increases glucose transporter 1 on plasma membranes and glucose uptake in an AKT-dependent manner in chicken adipocytes.
Shimamoto, General and comparative endocrinology 2019 (PubMed)- GeneRIF: GLUT1 is an insulin-responsive GLUT in chicken adipocytes.
- Effects of first exogenous nutrients on the mRNA levels of atrogin-1/MAFbx and GLUT1 in the skeletal muscles of newly hatched chicks.
Ijiri, Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 2017 (PubMed)- GeneRIF: effects of first exogenous nutrients on the mRNA levels of muscle atrophy F-box (atrogin-1/MAFbx) and glucose transporters (GLUTs) in the skeletal muscles of newly hatched chicks with no feed experience
- Gene expression pattern of glucose transporters in the skeletal muscles of newly hatched chicks.
Shimamoto, Bioscience, biotechnology, and biochemistry 2016 (PubMed)- GeneRIF: Phosphorylated AKT level was high in the skeletal muscles, suggesting a relationship between AKT and GLUT1 expression.
- Altered gene and protein expression of glucose transporter1 underlies dexamethasone inhibition of insulin-stimulated glucose uptake in chicken muscles.
Zhao, Journal of animal science 2012 (PubMed)- GeneRIF: The results of the present study indicate that the altered GLUT-1 gene and protein expression may contribute to the insulin resistance induced by dexamethasone treatment in chicken muscles.
An11g05280 uncharacterized protein from Aspergillus niger
32% identity, 81% coverage
STP4_ARATH / Q39228 Sugar transport protein 4; Hexose transporter 4 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
TC 2.A.1.1.49 / Q39228 The sink-specific, stress-regulated monosaccharide uptake porter, STP4. (Induced upon wounding or infection with bacteria or fungi; expressed in roots and flowers) from Arabidopsis thaliana (Mouse-ear cress) (see 6 papers)
STP4 / RF|NP_188627.1 sugar transport protein 4 from Arabidopsis thaliana (see paper)
AT3G19930 STP4 (SUGAR TRANSPORTER 4); carbohydrate transmembrane transporter/ monosaccharide transmembrane transporter/ sucrose:hydrogen symporter/ sugar:hydrogen symporter from Arabidopsis thaliana
29% identity, 89% coverage
- function: Mediates an active uptake of hexoses, probably by sugar/hydrogen symport. Can transport glucose, methylglucose, galactose, xylose and mannose, but not fructose.
- substrates: Sugars
- Starch metabolism in guard cells: At the intersection of environmental stimuli and stomatal movement
Dang, Plant physiology 2024 (no snippet) - AlteredArabidopsis thalianasugar metabolism affects exudation, immune responses, and plant-microbe interactions
Siffert, 2024 - An Integrated Analysis of microRNAs and the Transcriptome Reveals the Molecular Mechanisms Underlying the Regulation of Leaf Development in Xinyang Maojian Green Tea (Camellia sinensis)
Wang, Plants (Basel, Switzerland) 2023 - “...AT2G26950 csn-miR159-45 Upregulated (sBud/sS1), downregulated (sBud/sL1, sBud/sL2) AT3G57060 , AT2G03250 , AT4G18390 , AT2G13610 , AT3G19930 , AT2G43430 csn-miR160-2 Downregulated (sBud/sS1, sBud/sL1, sBud/sL2), AT1G77850 , AT2G28350 , AT4G30080 csn-miR162-2 downregulated (sBud/sS1) AT3G01330 , AT2G23180 csn-miR166-22 Downregulated (sBud/sS1, sBud/sL2) AT1G07810 , AT1G30490 , AT1G52150 csn-miR167-2 Upregulated (sBud/sS1,...”
- Membrane nanodomains and transport functions in plant
Martinière, Plant physiology 2021 - “...(NAP3) Suspension cell cultures Yoshida et al., 2013 Sugar Sugar transporter protein (STP) AT1G11260 (STP1); AT3G19930 (STP4); AT5G26340 (STP13) Whole plant/suspension cell cultures/leaves Minami et al., 2009 ; Keinath et al., 2010 ; Demir et al., 2013 Sugar (continued) Sucrose transporter (SUT) AT1G22710 (SUT1) Leaves Demir...”
- Glucose uptake to guard cells via STP transporters provides carbon sources for stomatal opening and plant growth
Flütsch, EMBO reports 2020 - “...the following accession numbers: ACT2, AT3G18780; BAM3, AT4G17090; KAT1, AT5G46240; MYB60, AT1G08810; STP1, AT1G11260; STP4, AT3G19930; STP13, AT5G26340; SUC1, AT1G71880 and SUC3, AT2G02860. References Alonso M , Stepanova AN , Leisse TJ , Kim CJ , Chen H , Shinn P , Stevenson DK , Zimmerman...”
- Rho GTPase ROP1 Interactome Analysis Reveals Novel ROP1-Associated Pathways for Pollen Tube Polar Growth in Arabidopsis
Li, International journal of molecular sciences 2020 - “...type of transporters were found for transmembrane trafficking of nutrients and energy, such as STP4&STP9 (AT3G19930 and AT1G50310) for sucrose and AT1G71680 for amino acids. 3.4. ROP1 Signaling and Endocytosis Exocytosis of secretory vesicles is critical for pollen tube expansion by supplying membrane, cell wall components,...”
- Plant glucose transporter structure and function
Geiger, Pflugers Archiv : European journal of physiology 2020 - “..., 161 ] AtSTP3 At5g61520 Source leaf Plasma membrane Glucose Low [ 19 ] AtSTP4 At3g19930 Pollen, root tips, leaf Plasma membrane Glucose, galactose, mannose, xylose, arabinose High [ 35 , 36 , 94 , 122 , 160 ] AtSTP5 At1g34580 Silique and whole seedling Plasma...”
- Genome-Wide Identification and Expression Profiling of Sugar Transporter Protein (STP) Family Genes in Cabbage (Brassica oleracea var. capitata L.) Reveals their Involvement in Clubroot Disease Responses
Zhang, Genes 2019 - “...LF 1542 513 56.62 8.70 30.38 106.57 0.56 cell membrane Clade II tPCK2 F AtSTP4 AT3G19930 1545 514 BoSTP4a Bol018147 C05 LF 1545 514 57.12 8.72 38.81 102.80 0.58 cell membrane BoSTP4b Bol000550 Scaffold000531 MF1 1545 514 56.99 8.99 38.20 102.80 0.56 cell membrane tPCK1 C...”
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XP_042998602 uncharacterized protein from Ustilaginoidea virens
31% identity, 78% coverage
GRMZM2G064437 proton myo-inositol cotransporter from Zea mays
33% identity, 85% coverage
- Genome-Wide Association Study of Maize Aboveground Dry Matter Accumulation at Seedling Stage
Lu, Frontiers in genetics 2020 - “...trait. For V3, GRMZM2G340279 , GRMZM2G347808 , GRMZM2G018782 , GRMZM2G099678 , GRMZM2G153127 , Zm00001d042998 , GRMZM2G064437 , and GRMZM2G030284 were associated with leaf dry matter. The candidate genes of sheath dry matter were GRMZM2G147917 , GRMZM2G164088 , GRMZM2G138770 , GRMZM2G032163 , GRMZM2G077004 , GRMZM2G092616 , GRMZM5G884544...”
- Analysis of weighted co-regulatory networks in maize provides insights into new genes and regulatory mechanisms related to inositol phosphate metabolism
Zhang, BMC genomics 2016 - “...related to carbohydrate metabolism. Representative genes include a UDP-galactose transporter (GRMZM2G089630, node CD2), carbohydrate/inositol-transporters (GRMZM2G063824, GRMZM2G064437, nodes CA1 and CC1), and a glycerol-3-phosphate transporter (GRMZM2G078757, node CC4). The correlation between IP6 levels and the expression of carbohydrate transporters (correlation coefficient ranged from 0.51 to 0.95, p...”
MST8_ORYSJ / Q94EC4 Sugar transport protein MST8; Monosaccharide transporter 8; OsMST8; Sugar:proton symporter MST8 from Oryza sativa subsp. japonica (Rice) (see 2 papers)
31% identity, 82% coverage
- function: Mediates active uptake of hexoses by sugar:proton symport (By similarity). May play an important role in transporting monosaccharides during anther development (Probable).
TC 2.A.1.1.50 / Q94AZ2 The glucose/fructose:H+ symporter, STP13 (sugar transport protein 13). Expressed in vascular tissues and induced during programmed cell death from Arabidopsis thaliana (Mouse-ear cress) (see 6 papers)
STP13 / RF|NP_198006.1 sugar transport protein 13 from Arabidopsis thaliana (see paper)
NP_198006 Major facilitator superfamily protein from Arabidopsis thaliana
AT5G26340 MSS1; carbohydrate transmembrane transporter/ hexose:hydrogen symporter/ high-affinity hydrogen:glucose symporter/ sugar:hydrogen symporter from Arabidopsis thaliana
31% identity, 85% coverage
- substrates: H+, fructose, glucose
tcdb comment: Used to combat bacterial infection by competing with them for sugars by phosphorylation of STP13 by the BAK1 receptor kinase (Yamada et al. 2016) - Differential Gene Expression Reveals Candidate Genes for Drought Stress Response in Abies alba (Pinaceae)
Behringer, PloS one 2015 - “...Q0DKW8 O . sativa subsp . japonica 5.63 STP13 - Sugar transport protein 13 - Q94AZ2 A . thaliana 5.52 RHA2A - E3 ubiquitin-protein ligase RHA2A a Q9ZT50 A . thaliana 5.36 GOLS1 - Galactinol synthase 1 - Q947G8 Solanum lycopersicum 4.94 LEA14-A a - LEA...”
- A comprehensive resource of drought- and salinity- responsive ESTs for gene discovery and marker development in chickpea (Cicer arietinum L.)
Varshney, BMC genomics 2009 - “...42 ]. The presence of protective compound such as 'sugar transport protein 13' (UniProt ID: Q94AZ2) during water stress conditions [ 43 ] in this cluster suggests a protective reaction to osmotic stress in sensitive genotypes as compared with tolerant genotypes. Similarly, the occurrence of 'glycine-rich...”
- Transcriptional activation of SUGAR TRANSPORT PROTEIN 13 mediates biotic and abiotic stress signaling.
Lee, Plant signaling & behavior 2021 - GeneRIF: Transcriptional activation of SUGAR TRANSPORT PROTEIN 13 mediates biotic and abiotic stress signaling.
- Regulation of sugar transporter activity for antibacterial defense in Arabidopsis.
Yamada, Science (New York, N.Y.) 2016 (PubMed)- GeneRIF: Stimulation of STP13 activity suppresses bacterial effector delivery, thereby reducing bacterial virulence.
- Expression of Arabidopsis sugar transport protein STP13 differentially affects glucose transport activity and basal resistance to Botrytis cinerea.
Lemonnier, Plant molecular biology 2014 (PubMed)- GeneRIF: This study showed that STP13-deficient plants exhibited an enhanced susceptibility to B. cinerea and a reduced rate of glucose uptake.
- Monosaccharide absorption activity of Arabidopsis roots depends on expression profiles of transporter genes under high salinity conditions.
Yamada, The Journal of biological chemistry 2011 - GeneRIF: The results indicate that STP13 can reabsorb the monosaccharides that are released by damaged cells under high salinity conditions.
- Over-expression of STP13, a hexose transporter, improves plant growth and nitrogen use in Arabidopsis thaliana seedlings.
Schofield, Plant, cell & environment 2009 (PubMed)- GeneRIF: Transgenic seedlings over-expressing STP13 had increased rates of glucose uptake, higher endogenous sucrose levels, accumulated more total C and biomass per plant, and and had higher levels of expression of the nitrate transporter NRT2.2.
- Phaseolus vulgaris STP13.1 is an H+-coupled monosaccharide transporter, present in source leaves and seed coats, with higher substrate affinity at depolarized potentials
Pegler, Plant direct 2024 - “...as the mean standard error. Figure S1: Amino acid sequence alignment of AtSTP10 (At3g19940), AtSTP13 (At5G26340) BvSTP13 (Bevul.3G139500), MdSTP13a (MD13G1189100), MtSTP13.1 (Medtr5g006070), MtSTP13.2 (Medtr1g104780), PvSTP13.1 (Phvul.002G046800), PvSTP13.2 (Phvul.007G055100) and TaSTP13 (Traes_4DL_CFC191A06). Amino acid residues encased in a red box indicate residues participating in AtSTP10 binding of...”
- Identification and expression profiling of proline metabolizing genes in Arabidopsis thaliana and Oryza sativa to reveal their stress-specific transcript alteration
Arabia, Physiology and molecular biology of plants : an international journal of functional plant biology 2021 - “...F-box family protein (At2g27310), STP13 (At5g26340), alpha/betaHydrolases (At2g39420), kinase (At1g74360), Thioredoxin superfamily protein (At1g28480) Chl...”
- Membrane nanodomains and transport functions in plant
Martinière, Plant physiology 2021 - “...cell cultures Yoshida et al., 2013 Sugar Sugar transporter protein (STP) AT1G11260 (STP1); AT3G19930 (STP4); AT5G26340 (STP13) Whole plant/suspension cell cultures/leaves Minami et al., 2009 ; Keinath et al., 2010 ; Demir et al., 2013 Sugar (continued) Sucrose transporter (SUT) AT1G22710 (SUT1) Leaves Demir et al.,...”
- Leaf nodule endosymbiotic Burkholderia confer targeted allelopathy to their Psychotria hosts
Georgiou, Scientific reports 2021 - “...(AT2G36190), cwinv5 (AT3G13784), cwinv6 (AT5G11920), cinv1-4 (AT1G35580), cinv1-8 ( AT1G35580), cinv2 (AT4G09510), stp1-1 (AT1G11260), stp13-1 (AT5G26340) and the double mutants stp1 stp13 and stp1 stp4 were kindly provided by Diana Santelia (ETH Zurich, Switzerland); prc1 (AT5G64740) , cev1 (AT5G05170) and rsw1 (AT4G32410) were obtained from Clara...”
- Transcriptome analysis of Rafflesia cantleyi flower stages reveals insights into the regulation of senescence
Mohd-Elias, Scientific reports 2021 - “...Target of rapamycin (TOR) AT1G50030 Promote UN013404 ABC transporter AT5G06530 Unclear UN004449 Sugar transporter 14 AT5G26340 Unclear UN026074 Nitrate transporter AT1G32450 Unclear UN015723 Polyamine transporter AT1G31830 Unclear Redox regulation UN004263 Catalase (CAT) AT1G20630 Unclear UN012078 Superoxide dismutase (SOD) AT3G56350 Unclear UN037470 L-Ascorbate oxidase (ASO) AT1G76160 Unclear...”
- Transcriptome analysis of Pará rubber tree (H. brasiliensis) seedlings under ethylene stimulation
Nakano, BMC plant biology 2021 - “...bx012963 AT5G61520 AtSTP3 2.52 1.96 0.72 0 bx006914 AT5G26250 AtSTP8 1.85 0.26 2.76 1 bx027564 AT5G26340 AtSTP13 5.35 5.31 2.58 2 bx055460 AT1G77210 AtSTP14 3.04 3.23 2.81 H+-Symporter family for polyols and monosaccharides (plasma membrane) 0 bx046600 AT2G18480 AtPLT3 6.25 6.26 6.34 Putative monosaccharide transporter family...”
- Dynamic Development of White Lupin Rootlets Along a Cluster Root
Le, Frontiers in plant science 2021 - “...(HKT1) Potassium Profile 5 Lalb_Chr09g0332731 AT4G23700 Cation/H + exchanger 17 (CHX17) Sodium Profile 5 Lalb_Chr05g0210921 AT5G26340 Sugar transport protein 13 (STP13) Sugar Profile 6 Lalb_Chr06g0160591 AT5G26340 Sugar transport protein 13 (STP13) Sugar Profile 5 Lalb_Chr20g0123111 AT1G22150 Sulfate transporter 1;3 (Sultr1;3) Sulfate Profile 4 Lalb_Chr01g0018841 AT2G16850 Plasma...”
- AsHSP26.8a, a creeping bentgrass small heat shock protein integrates different signaling pathways to modulate plant abiotic stress response
Sun, BMC plant biology 2020 - “...1.07 late embryogenesis abundant hydroxyproline-rich glycoprotein Carbohydrate metabolism-related proteins AT3G09020 1.37 alpha 1,4-glycosyltransferase family protein AT5G26340 1.37 sugar transport protein 13 AT5G18840 2.66 sugar transporter ERD6-like 16 AT3G49790 1.18 Carbohydrate-binding protein Nitrogen metabolism-related proteins AT1G02920 1.26 glutathione S-transferase 7/11 AT2G02930 1.48 glutathione S-transferase F3 AT5G62480 2.05...”
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LOC8056880 sugar transport protein 13 from Sorghum bicolor
31% identity, 85% coverage
- Deciphering the Genetic Mechanisms of Salt Tolerance in Sorghum bicolor L.: Key Genes and SNP Associations from Comparative Transcriptomic Analyses
Jeon, Plants (Basel, Switzerland) 2023 - “...with salt tolerance were inferred, including LOC8071970 , LOC8067721 , LOC110430887 , LOC8070256 , and LOC8056880 . These genes demonstrated notable differences in nsSNPs in comparison to the wild type, suggesting their potential roles in salt tolerance. Additionally, LOC8060874 (cyanohydrin beta-glucosyltransferase) was suggested as a key...”
- “...abiotic stress such as wounding, extreme temperatures, UV-rays, oxidative stress, and drought [ 50 ]. LOC8056880 is a functional sugar transport protein 13. Six nsSNPs were detected in the mutant, which is six times higher than in the wild type. SWEETs (Sugars Will Eventually be Exported...”
FVEG_07757 hypothetical protein from Fusarium verticillioides 7600
31% identity, 83% coverage
- Involvement of FST1 from Fusarium verticillioides in virulence and transport of inositol
Niu, Molecular plant pathology 2017 (secret) - Transcriptome changes in Fusarium verticillioides caused by mutation in the transporter-like gene FST1
Niu, BMC microbiology 2015 - “...yeast ITR1p sequence identified eight genes with high sequence similarity (FVEG_01519, FVEG_01638, FVEG_02081, FVEG_03992, FVEG_06504, FVEG_07757, FVEG_11293, and FVEG_12687). The sequence of FST1 was not identified by the search. Among the eight identified genes, expression was significantly down-regulated in fst1 for FVEG_06504 (named ITR1 ) (19-fold)...”
C0PHL2 Monosaccharide transporter1 from Zea mays
31% identity, 81% coverage
lpp1624 hypothetical protein from Legionella pneumophila str. Paris
32% identity, 91% coverage
STP2_ARATH / Q9LNV3 Sugar transport protein 2; Hexose transporter 2 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
TC 2.A.1.1.48 / Q9LNV3 The pentose/hexose transporter (sugar transport protein 2), STP2. (Expressed during pollen maturation and early stages of gametophyte development) from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
AT1G07340 ATSTP2 (SUGAR TRANSPORTER 2); carbohydrate transmembrane transporter/ monosaccharide transmembrane transporter/ sugar:hydrogen symporter from Arabidopsis thaliana
32% identity, 87% coverage
- function: Mediates an active uptake of hexoses, probably by sugar/hydrogen symport. Can transport glucose, 3-O-methylglucose, xylose, mannose, fructose and galactose.
- substrates: Sugars
- Inferring the genetic responses to acute drought stress across an ecological gradient
Devitt, BMC genomics 2022 - “...protein 1 O82663 SDHA1_ARATH Succinate dehydrogenase flavoprotein subunit 1 Q39232 SUC1_ARATH Sucrose transport protein SUC1 Q9LNV3 STP2_ARATH Sugar transport protein 2 Q24JK1 MYB96_ARATH Transcription factor MYB96 Q9SNC6 PUB13_ARATH U-box domain-containing protein 13 Q8RWG1 AB1K1_ARATH Protein activity of BC1 complex kinase 1 Q39096 ERD15_ARATH Protein early responsive...”
- Optimizing pentose utilization in yeast: the need for novel tools and approaches
Young, Biotechnology for biofuels 2010 - “...Species Gene or DNA Library UniProt Plasmid Study Strain Xylose transport phenotype Arabidopsis thaliana Stp2 Q9LNV3 p4H7 [ 64 ] TMB3201 - Arabidopsis thaliana Stp3 Q8L7R8 p4H7 [ 64 ] TMB3201 - Arabidopsis thaliana At5g59250 Q0WWW9 p4H7 [ 64 ] TMB3201 - Arabidopsis thaliana At5g59250 Q0WWW9...”
- Pollen Number and Ribosome Gene Expression Altered in a Genome-Editing Mutant of REDUCED POLLEN NUMBER1 Gene
Kakui, Frontiers in plant science 2021 - “...0.546 Down 0.06193 AT1G06515 ssSPTa SMALL SUBUNIT OF SPT A 68.015 44.575 0.655 Down 0.03059 AT1G07340 STP2 SUGAR TRANSPORTER 2 39.175 27.415 0.700 Down 0.02665 AT3G47440 TIP5;1 TONOPLAST INTRINSIC PROTEIN 5;1 3.16325 1.8435 0.583 Down 0.09475 AT4G35420 TKPR1 TETRAKETIDE ALPHA-PYRONE REDUCTASE 1 265 163.175 0.616 Down...”
- Plant glucose transporter structure and function
Geiger, Pflugers Archiv : European journal of physiology 2020 - “...High [ 24 , 35 , 103 , 139 , 150 , 178 ] AtSTP2 At1g07340 Early male gametophyte development Plasma membrane Glucose, galactose, mannose, xylose, arabinose High [ 154 , 161 ] AtSTP3 At5g61520 Source leaf Plasma membrane Glucose Low [ 19 ] AtSTP4 At3g19930...”
- Genome-Wide Identification and Expression Profiling of Sugar Transporter Protein (STP) Family Genes in Cabbage (Brassica oleracea var. capitata L.) Reveals their Involvement in Clubroot Disease Responses
Zhang, Genes 2019 - “...LF 1569 522 57.17 5.79 33.58 105.50 0.55 cell membrane Clade III tPCK1 A AtSTP2 AT1G07340 1497 498 BoSTP2a Bol023380 C08 MF1 1497 498 55.48 9.27 38.43 105.52 0.50 cell membrane BoSTP2b Bol041122 C05 LF 1500 499 55.42 9.29 33.25 105.51 0.52 cell membrane tPCK2 F...”
- Modulation of Auxin Levels in Pollen Grains Affects Stamen Development and Anther Dehiscence in Arabidopsis
Salinas-Grenet, International journal of molecular sciences 2018 - “...promoters were designated as early pollen promoter (from the sugar transporter 2 gene, STP2 , At1g07340), intermediate pollen promoter 1 (from the sugar transporter 9 gene, STP9 , At1g50310), intermediate pollen promoter 2 (from the pollen-specific gene 2 gene, PSG2 , At1g28550), and late pollen promoter...”
- C4 Protein of Sweet Potato Leaf Curl Virus Regulates Brassinosteroid Signaling Pathway through Interaction with AtBIN2 and Affects Male Fertility in Arabidopsis
Bi, Frontiers in plant science 2017 - “...et al., 2010 ). It was found that the expression levels of At4g28395, At3g42960, At3g51590, At1g07340, At3g23770, At1g61110 , and At5g62320 in C4-11, C4-36, and C4-37 were lower than that in the wild type, while the expression level of At2g18550 was higher than the wild type...”
- Transcriptomic and proteomic approach to identify differentially expressed genes and proteins in Arabidopsis thaliana mutants lacking chloroplastic 1 and cytosolic FBPases reveals several levels of metabolic regulation
Soto-Suárez, BMC plant biology 2016 - “...file 1 : Table S1 and Additional file 5 : Table S4). Sugar transporter 2 (At1g07340) and three sugar transporter family proteins (At3g05155, At4g04760, At3g19940) were up-regulated in cyfbp rosettes, and only a mannitol transporter (At2g20780) was down-regulated. Finally, a carbohydrate transmembrane transporter (At1g08930) and two...”
- “...glycolysis and gluconeogenesis (At4g15210, At5g20830 and At1g50460), photosynthesis and Calvin-cycle-related genes (At1g79530 and At2g39730), transport (At1g07340 and At3g19930), development (At5g24780), redox regulation (At1g76760 and At1g28480), miscellaneous enzymes (At5g20340), and unassigned biological process (At1g67850). The QRT-PCR results supported microarray data, and also showed that the gene-expression pattern...”
- The pectin lyases in Arabidopsis thaliana: evolution, selection and expression profiles
Cao, PloS one 2012 - “...A pectin lyase, AT1G05650, was found to be interacted with three transporters, AtSTP1 (AT2G13650), AtSTP2 (AT1G07340) and AtSTP9. In addition, two other sugar transporters, AtSTP14 (AT1G77210) and AtSTP12 (AT4G21480) might be the potential interactors of the pectin lyases, AT1G43080 and AT5G44830, respectively. Thus, whether sugar transportation...”
- The Vitis vinifera sugar transporter gene family: phylogenetic overview and macroarray expression profiling
Afoufa-Bastien, BMC plant biology 2010 - “...Bootstrapping was performed with 100 replicates. Accession numbers for Arabidopsis thaliana transporters are: At1g11260 (AtSPT1), At1g07340 (AtSTP2), At5g61520 (AtSTP3), At3g19930 (AtSTP4), At1g34580 (AtSTP5), At3g05960 (AtSTP6), At4g02050 (AtSTP7), At5g26250 (AtSTP8), At1g50310 (AtSTP9), At3g19940 (AtSTP10), At5g23270 (AtSTP11), At4g21480 (AtSTP12), At5g26340 (AtSTP13), At1g77210 (AtSTP14); for Vitis ones see Additional...”
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B6TDG1 Proton myo-inositol cotransporter from Zea mays
33% identity, 85% coverage
- Growth Stimulatory Effects and Genome-Wide Transcriptional Changes Produced by Protein Hydrolysates in Maize Seedlings.
Santi, Frontiers in plant science 2017 - “...2.70 GRMZM2G118507_T01 K7VD86 Uncharacterized protein 2.65 GRMZM2G024196_T01 Q7XKF4 Probable metal-nicotianamine transporter YSL13 2.53 3.89 GRMZM2G064437_T01 B6TDG1 Proton myo-inositol cotransporter 2.53 GRMZM2G059465_T01 K7TWC7 Calcium-transporting ATPase 2.49 GRMZM2G129843_T01 B6U7Q9 Lipid binding protein 2.41 GRMZM2G362848_T01 V9SBV7 Nucleobase cation symporter 1 2.32 GRMZM2G029951_T01 A0A096Q8Z7 Uncharacterized protein 2.29 GRMZM2G123884_T01 Q7XVB3 Probable...”
SS1G_07132 hypothetical protein from Sclerotinia sclerotiorum 1980 UF-70
32% identity, 76% coverage
STP10_ARATH / Q9LT15 Sugar transport protein 10; AtSTP10; D-glucose-H(+) symport protein STP10; D-glucose-proton symporter STP10; Hexose transporter 10 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
TC 2.A.1.1.124 / Q9LT15 The high affinity sugar:H+ symporter (sugar uptake) porter of 514 aas and 12 TMSs, STP10. It transports glucose, galactose and mannose, and is therefore a hexose transporter (Rottmann et al. 2016). The 2.4 from Arabidopsis thaliana
NP_188628 Major facilitator superfamily protein from Arabidopsis thaliana
AT3G19940 sugar transporter, putative from Arabidopsis thaliana
30% identity, 85% coverage
- function: Hexose-H(+) symporter that catalyzes the high-affinity uptake of glucose, galactose and mannose (PubMed:26893494). Proton-coupled symporter responsible for the uptake of glucose from the apoplast into the cells (Probable).
catalytic activity: D-glucose(out) + H(+)(out) = D-glucose(in) + H(+)(in) (RHEA:69556)
catalytic activity: D-mannose(out) + H(+)(out) = D-mannose(in) + H(+)(in) (RHEA:69560)
catalytic activity: D-galactose(in) + H(+)(in) = D-galactose(out) + H(+)(out) (RHEA:29019)
disruption phenotype: No visible phenotype under normal growth conditions. - substrates: Galactose, Hexoses, Mannose, glucose
tcdb comment: Å structure with glucose bound has been solved, explaining high affinity sugar recognition (Paulsen et al. 2019). The results suggest a proton donor/acceptor pair that links sugar transport to proton translocation. It contains a Lid domain, conserved in all sugar transport proteins, that locks the mobile transmembrane domains through a disulfide bridge, and creates a protected environment which allows efficient coupling of the proton gradient to drive sugar uptake (Paulsen et al. 2019) - Molecular mechanism of sugar transport in plants unveiled by structures of glucose/H+ symporter STP10.
Bavnhøj, Nature plants 2021 (PubMed)- GeneRIF: Molecular mechanism of sugar transport in plants unveiled by structures of glucose/H(+) symporter STP10.
- STP10 encodes a high-affinity monosaccharide transporter and is induced under low-glucose conditions in pollen tubes of Arabidopsis.
Rottmann, Journal of experimental botany 2016 - GeneRIF: A high-affinity glucose uptake system is induced in growing pollen tubes under low glucose conditions and that this regulation may occur through the hexokinase pathway. [AtSTP10]
- Evolutionary balance between foldability and functionality of a glucose transporter
Choi, Nature chemical biology 2022 - “...transporter 1 (O97467), Staphylococcus epidermidis Glucose transporter (A0A0H2VG78) and Arabidopsis thaliana Sugar transport protein 10 (Q9LT15). The PDB accession number for structures for these reference proteins are 4ZWC (P11169), 4GBZ (P0AGF4), 6RW3 (O97467), 4LDS (A0A0H2VG78) and 6H7D (Q9LT15). Since the sequences are divergent and therefore difficult...”
- “...4LDS and 6H7D). Also, The following UniProt IDs were used (P11169, P0AGF4, O97467, A0A0H2VG78 and Q9LT15). Code availability A program, written in LabView, to control the magnetic tweezers apparatus has been deposited in Github ( https://github.com/tyyoonlab/Science_aaw8208 ) and is available at Zenodo (doi:10.5281/zenodo.3528913). Codes for analyzing...”
- Utilization of AlphaFold2 to Predict MFS Protein Conformations after Selective Mutation.
Xiao, International journal of molecular sciences 2022 - “...To date, several structures of MFS proteins (UniProt ID: P0AA76, P0AEY8, P0AGF4, P02920, Q6MLJ0, and Q9LT15) have been found in both the outward- and inward-opening conformations [ 9 , 10 , 11 , 12 , 30 , 31 , 32 , 33 , 34 , 35...”
- “...5AYM) for Q6MLJ0, 0.88 (inward, PDB ID: 7AAR) and 0.75 (outward, PDB ID: 7AAQ) for Q9LT15, and 0.39 (inward, PDB ID: 4ZP0) and 1.95 (outward, PDB ID: 6GV1) for P0AEY8. Most of these predicted structures, including mutants, have approximately 1 or less deviation from the experimentally...”
- Structural comparison of GLUT1 to GLUT3 reveal transport regulation mechanism in sugar porter family
Custódio, Life science alliance 2021 - “...), GLUT4 (UniProt P14672 ), rGLUT5 (UniProt P43427 ), bGLUT5 (UniProt P58353 ), atSTP10 (UniProt Q9LT15 ), XylE (UniProt P0AGF4 ), and GlcPse (UniProt A0A0H2VG78 ). Conserved residues are highlighted with gray-scale. Alpha helices as found in GLUT1 are represented above the sequence as colored tubes....”
- SLC22A14 is a mitochondrial riboflavin transporter required for sperm oxidative phosphorylation and male fertility.
Kuang, Cell reports 2021 - “...etal., 2019 ) revealed that both the human SLC22A14 and the A.thaliana STP10 (UniProt entry Q9LT15) belonged to the Major facilitator, sugar transporter-like protein family (IPR005828), strengthening our confidence that the correct template had been chosen. Finally, quality of the models was assessed using MolProbity (...”
- Crystal structure of the plant symporter STP10 illuminates sugar uptake mechanism in monosaccharide transporter superfamily
Paulsen, Nature communications 2019 - “...plant life. Methods Protein purification The gene encoding the Arabidopsis thaliana protein STP10 (Accession number Q9LT15 [ https://www.uniprot.org/uniprot/Q9LT15 ]) was introduced into an expression construct based on p423_GAL1 40 with a C-terminal purification tag containing a thrombin cleavage site and a deca-histidine tag. The primers used...”
- Phaseolus vulgaris STP13.1 is an H+-coupled monosaccharide transporter, present in source leaves and seed coats, with higher substrate affinity at depolarized potentials
Pegler, Plant direct 2024 - “...is presented as the mean standard error. Figure S1: Amino acid sequence alignment of AtSTP10 (At3g19940), AtSTP13 (At5G26340) BvSTP13 (Bevul.3G139500), MdSTP13a (MD13G1189100), MtSTP13.1 (Medtr5g006070), MtSTP13.2 (Medtr1g104780), PvSTP13.1 (Phvul.002G046800), PvSTP13.2 (Phvul.007G055100) and TaSTP13 (Traes_4DL_CFC191A06). Amino acid residues encased in a red box indicate residues participating in AtSTP10...”
- Calmodulin-Domain Protein Kinase PiCDPK1 Interacts with the 14-3-3-like Protein NtGF14 to Modulate Pollen Tube Growth
Scheible, Plants (Basel, Switzerland) 2024 - “...Epsin family of endocytic proteins Accessory proteins that facilitate vesicle biogenesis [ 41 ] A0A1S4AFS9 AT3G19940 Sugar Transport Protein 10 Sugar Transport Protein Glucose uptake in growing pollen tubes [ 42 ] A0A1S4AKF1 AT1G16010 Magnesium Transporter 2 Transmembrane magnesium transporter Tonoplast-targeted transporter for vacuolar accumulation of...”
- Exploring the genic resources underlying metabolites through mGWAS and mQTL in wheat: From large-scale gene identification and pathway elucidation to crop improvement
Chen, Plant communications 2021 - “...behind the accumulation of the metabolite sucrose ( Chen etal., 2020 ). Their orthologin Arabidopsis AT3G19940 , which is also known as STP10 , encodes a high-affinity hexose transporter ( Rottmann etal., 2016 ). These examples thus collectively demonstrate that the approach enables us to identify...”
- Plant glucose transporter structure and function
Geiger, Pflugers Archiv : European journal of physiology 2020 - “...developed pollen grain Plasma membrane Glucose, galactose, arabinose High [ 122 , 131 ] AtSTP10 At3g19940 Germinating pollen and growing pollen Plasma membrane Glucose, galactose, mannose, High [ 109 , 122 , 124 ] AtSTP11 At5g23270 Fully mature pollen and growing pollen tubes Plasma membrane Glucose,...”
- Metabolite-based genome-wide association study enables dissection of the flavonoid decoration pathway of wheat kernels
Chen, Plant biotechnology journal 2020 - “...respectively. The top hit of these candidates ( TraesCS4B01G371700 and TraesCS4D01G365800 ) in Arabidopsis ( AT3G19940 , also known as SPT10 ) encodes a highaffinity hexose transporter carrying glucose and other monosaccharides (Paulsen et al. , 2019 ; Rottmann et al. , 2016 ). Similarly, for...”
- Genome-Wide Identification and Expression Profiling of Sugar Transporter Protein (STP) Family Genes in Cabbage (Brassica oleracea var. capitata L.) Reveals their Involvement in Clubroot Disease Responses
Zhang, Genes 2019 - “...Bol014014 Scaffold000180 MF2 1551 516 56.15 6.89 33.77 101.67 0.54 cell membrane tPCK2 F AtSTP10 AT3G19940 1545 514 BoSTP10 Bol000549 Scaffold000531 MF1 1536 511 56.16 8.60 30.51 97.50 0.48 cell membrane tPCK7 Q AtSTP11 AT5G23270 1545 514 BoSTP11 Bol017091 C06 LF 1569 522 57.17 5.79 33.58...”
- Transcriptomic and proteomic approach to identify differentially expressed genes and proteins in Arabidopsis thaliana mutants lacking chloroplastic 1 and cytosolic FBPases reveals several levels of metabolic regulation
Soto-Suárez, BMC plant biology 2016 - “...: Table S4). Sugar transporter 2 (At1g07340) and three sugar transporter family proteins (At3g05155, At4g04760, At3g19940) were up-regulated in cyfbp rosettes, and only a mannitol transporter (At2g20780) was down-regulated. Finally, a carbohydrate transmembrane transporter (At1g08930) and two UDP-galactose transporters (At4g23010 and At3g59360) were up-regulated in cyfbp...”
- STP10 encodes a high-affinity monosaccharide transporter and is induced under low-glucose conditions in pollen tubes of Arabidopsis
Rottmann, Journal of experimental botany 2016 - “...microarray data furthermore indicate a rather high expression of the so far uncharacterized STP10 ( At3g19940 ) in pollen tubes. In the present paper, we describe the detailed characterization of the Arabidopsis monosaccharide transporter gene STP10 , which is expressed in pollen tubes and also in...”
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AL01_03445 sugar porter family MFS transporter from Bombella intestini
34% identity, 95% coverage
FTH_0853 MFS family major facilitator transporter from Francisella tularensis subsp. holarctica OSU18
31% identity, 94% coverage
7aaqA / Q9LT15 Sugar/h+ symporter stp10 in outward occluded conformation (see paper)
30% identity, 89% coverage
- Ligand: beta-d-glucopyranose (7aaqA)
FGSG_04700 hypothetical protein from Fusarium graminearum PH-1
32% identity, 82% coverage
An11g01100 uncharacterized protein from Aspergillus niger
32% identity, 83% coverage
LOC123092952 sugar transport protein MST4 from Triticum aestivum
30% identity, 87% coverage
- Expression Profiling of the Slow Rusting Resistance Genes Lr34/Yr18 and Lr67/Yr46 in Common Wheat (Triticum aestivum L.) and Associated miRNAs Patterns
Spychała, Genes 2023 - “...genes three very similar duplicates were identified in common wheat genome (LOC123169079, LOC123087958, LOC123152986 and LOC123092952, LOC123098224, LOC123085159, respectively); therefore, universal primers were designed, amplifying studied genes together with other similar homologs ( Table 1 ). For each primer pair (i.e., each gene), a PCR with...”
Bbr_0851 sugar porter family MFS transporter from Bifidobacterium breve UCC2003
30% identity, 89% coverage
LOC123098224 sugar transport protein MST4-like from Triticum aestivum
30% identity, 87% coverage
- Expression Profiling of the Slow Rusting Resistance Genes Lr34/Yr18 and Lr67/Yr46 in Common Wheat (Triticum aestivum L.) and Associated miRNAs Patterns
Spychała, Genes 2023 - “...three very similar duplicates were identified in common wheat genome (LOC123169079, LOC123087958, LOC123152986 and LOC123092952, LOC123098224, LOC123085159, respectively); therefore, universal primers were designed, amplifying studied genes together with other similar homologs ( Table 1 ). For each primer pair (i.e., each gene), a PCR with gradient...”
XP_043000657 uncharacterized protein from Ustilaginoidea virens
31% identity, 82% coverage
An06g00560 uncharacterized protein from Aspergillus niger
30% identity, 80% coverage
- In Silico Analysis of Putative Sugar Transporter Genes in Aspergillus niger Using Phylogeny and Comparative Transcriptomics
Peng, Frontiers in microbiology 2018 - “...(An14g04280) ( Sloothaak et al., 2014 ) and the D -xylose transporter encoding gene xltA (An06g00560) ( Sloothaak et al., 2016b ) were also clearly induced by their corresponding sugars. Interestingly, several transporters lacking solid experimental proof of function also had highly specific expression profiles. For...”
- “...et al., 2013 ), in which An03g01620 and An08g01720 were also affected by AraR, while An06g00560 ( xltA ) was under control of XlnR. While some of the transporters appear to be under control of the same regulators (e.g., XlnR, AmyR, and RhaR) that control polysaccharide...”
- Construction of an improved Aspergillus niger platform for enhanced glucoamylase secretion
Fiedler, Microbial cell factories 2018 - “...metabolism and calcium signalling, also four genes supposedly related to carbon catabolism were differentially expressed: An06g00560 (ortholog of the Saccharomyces cerevisiae Hxt13p hexose transporter) and An12g00160 (ortholog of the Saccharomyces cerevisiae Mae1 malic enzyme) were both up-regulated, whereas An16g01770 (predicted xylose reductase) and An07g01340 (predicted phosphoenolpyruvate...”
- RNA-sequencing reveals the complexities of the transcriptional response to lignocellulosic biofuel substrates in Aspergillus niger
Pullan, Fungal biology and biotechnology 2014 - “...38.20 1.72 676.84 <0.01 TID_38375 An08g04040 transmembrane transporter activity 0.53 7.98 0.84 32.31 <0.01 TID_55668 An06g00560 transmembrane transporter activity 0.19 24.08 0.30 263.55 <0.01 TID_180069 An07g02540 transmembrane transporter activity 0.10 2.05 0.75 43.05 <0.01 TID_197549 An02g08230 transmembrane transporter activity 0.26 18.83 0.09 146.66 <0.01 TID_54095 An18g01700...”
- The transcriptomic signature of RacA activation and inactivation provides new insights into the morphogenetic network of Aspergillus niger
Kwon, PloS one 2013 - “...permease An18g01220 Dal5 oligopeptide transporter An13g01760 Opt1 An15g07460 Opt1 oligopeptide transporter An11g01040 Opt1 hexose/glucose transporter An06g00560 Hxt13 An09g04810 amino acid transporter An03g00430 galactose transporter An01g10970 Gal2 FAD transporter into endoplasmatic reticulum, CWI-related An01g09050 Flc2 Protein trafficking GTPase activating protein involved in protein trafficking An01g02860 Gyp8 An15g01560...”
- Uncovering the genome-wide transcriptional responses of the filamentous fungus Aspergillus niger to lignocellulose using RNA sequencing
Delmas, PLoS genetics 2012 - “...38375 An08g04040 Similarity to quinate transport protein QutD - Aspergillus nidulans 1.7 141.9 2.9 55668 An06g00560 Similarity to hexose transporter Hxt13 - Saccharomyces cerevisiae 0.6 124.0 3.7 180069 An07g02540 Similarity to carboxylic acid transport protein Jen1 - Saccharomyces cerevisiae 1.5 108.6 2.0 197549 An02g08230 Similarity to...”
- Analysis of variance components reveals the contribution of sample processing to transcript variation
van, Applied and environmental microbiology 2009 - “...An09g03300 An03g00500 An15g01500 An11g01100 An03g01620 An06g00560 An01g10920 An01g03740 An12g00030 An07g03140 An02g03590 Signal sequence predicted Yes Yes...”
XP_042994564 uncharacterized protein from Ustilaginoidea virens
33% identity, 74% coverage
LOC102620675 sugar transport protein 13 from Citrus sinensis
31% identity, 82% coverage
- Plant volatile-triggered defense in citrus against biotic stressors
Pérez-Hedo, Frontiers in plant science 2024 - “...synthesis proteins for sugar synthesis during photosynthesis and the sugar transport proteins like STP13 ( LOC102620675 ). Genes associated with cell wall synthesis, including cellulose synthase A ( CSLG3 ) ( LOC102624770 ), expansin-B1 ( Ptrif.0004s1042 ), extensin-2 ( LOC102608242 ), extensin-3 ( LOC102627738 ), and...”
ITR2_SCHPO / P87110 Myo-inositol transporter 2 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
itr2 / RF|NP_593320.1 MFS myo-inositol transporter from Schizosaccharomyces pombe (see 2 papers)
31% identity, 78% coverage
- function: Transporter for myo-inositol.
catalytic activity: H(+)(out) + myo-inositol(out) = H(+)(in) + myo-inositol(in) (RHEA:60364) - CharProtDB Source (per GeneDB): GeneDB_Spombe
Sb02g024060 No description from Sorghum bicolor
34% identity, 88% coverage
- A major locus for chloride accumulation on chromosome 5A in bread wheat
Genc, PloS one 2014 - “...Sb02g023620 Traes_5AL_B64648FE6 Potassium transporter family (HKT23-like) Bradi4g29440 LOC_Os09g21340/Os09g0381100 Sb02g023720 WHE1104_A05_B10ZS;WHE0807_A06_B11ZS; Traes_5AL_3E0C865DF Nucleobase-ascorbate transporter Bradi4g29650 LOC_Os09g23110/Os09g0394500 Sb02g024060 Traes_5AL_01A13992D;Traes_5AL_B8B668113 ABC transporter Bradi4g29720 LOC_Os09g23300/Os09g0396900 Sb02g024130 WHE1787_E02_I03ZS; Traes_5AL_F80B422BA Vacuolar iron transporter 1 (VIT1) Bradi4g29810 LOC_Os09g23640/Os09g0401100 - Traes_5AL_678EA44B2 ABC transporter a according to MSU Rice Genome Annotation Project release 7, Ensembl...”
ACA1_060920 transporter, major facilitator superfamily protein from Acanthamoeba castellanii str. Neff
32% identity, 70% coverage
- First Reports of Effects of Insulin, Human-like Insulin Receptors and Adapter Proteins in Acanthamoeba castellanii
Baig, Scientific reports 2020 - “...a homolog of human-IR. Acanthamoeba protein ACA1_336150 shares similarities with IGF1-R. Additionally, some proteins like ACA1_060920 have attributes of GLUT like channels on homology modelling and show similarity with human GLUT. Knowledge of IR and insulin effects in Acanthamoeba spp. contributes to its biology and advances...”
- “...proteins like IR, GLUT and adapter proteins involved in signal transduction pathways with the ACA1_163470, ACA1_060920 and ACA1_ 176180 proteins of amoebal origin. Homology modelling of ACA1_163470, ACA1_060920 and ACA1_ 176180 The SWISS-MODEL automated server 23 , 24 was used to build template-based models of the...”
LOC123085159 sugar transport protein MST4-like from Triticum aestivum
30% identity, 83% coverage
- Expression Profiling of the Slow Rusting Resistance Genes Lr34/Yr18 and Lr67/Yr46 in Common Wheat (Triticum aestivum L.) and Associated miRNAs Patterns
Spychała, Genes 2023 - “...very similar duplicates were identified in common wheat genome (LOC123169079, LOC123087958, LOC123152986 and LOC123092952, LOC123098224, LOC123085159, respectively); therefore, universal primers were designed, amplifying studied genes together with other similar homologs ( Table 1 ). For each primer pair (i.e., each gene), a PCR with gradient of...”
TC 2.A.1.1.117 / G4N740 Glucose transporter Rco-3 or MoST1. MoST1 plays a specific role in conidiation and mycelial melanization which is not shared by other hexose transporter family members in M. oryzae from Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
XP_003716272 glucose transporter rco-3 from Pyricularia oryzae 70-15
33% identity, 78% coverage
TC 2.A.1.1.119 / A2R3H2 The galacturonic acid (galacturonate) uptake porter, GatA, of 518 aas and 12 TMSs from Aspergillus niger (strain CBS 513.88 / FGSC A1513)
An14g04280 uncharacterized protein from Aspergillus niger
31% identity, 88% coverage
- substrates: Galacturonate
- In Silico Analysis of Putative Sugar Transporter Genes in Aspergillus niger Using Phylogeny and Comparative Transcriptomics
Peng, Frontiers in microbiology 2018 - “...expressed on hexose substrates than other monosaccharides. The D -galacturonic acid transporter encoding genes gatA (An14g04280) ( Sloothaak et al., 2014 ) and the D -xylose transporter encoding gene xltA (An06g00560) ( Sloothaak et al., 2016b ) were also clearly induced by their corresponding sugars. Interestingly,...”
- Engineering Saccharomyces cerevisiae for co-utilization of D-galacturonic acid and D-glucose from citrus peel waste
Protzko, Nature communications 2018 - “...these transporters, we additionally incubated cultures at pH 3.5 (Supplementary Fig. 7 ). We identified An14g04280, or GatA 36 , from A. niger as a transporter that allowed for 11.9g/L consumption of d -galUA at high pH in our catabolic strain during the course of the...”
- Inducer-independent production of pectinases in Aspergillus niger by overexpression of the D-galacturonic acid-responsive transcription factor gaaR
Alazi, Applied microbiology and biotechnology 2018 - “...#N/A #N/A #N/A NRRL3_10115 An11g00390 rhamnogalacturonan lyase PL4_3 0.648 0.810 11.176 #N/A #N/A #N/A NRRL3_00958 An14g04280 MFS-type sugar/inositol transporter GatA 3.472 524.952* 125.820* #N/A #N/A #N/A NRRL3_08663 An03g01620 MFS-type sugar/inositol transporter 0.274 5.622* 0.577 #N/A #N/A #N/A NRRL3_04281 An07g00780 MFS-type transporter 3.110 4.596 13.958* #N/A #N/A...”
- The pathway intermediate 2-keto-3-deoxy-L-galactonate mediates the induction of genes involved in D-galacturonic acid utilization in Aspergillus niger
Alazi, FEBS letters 2017 - “...Gene ID CBS513.88 Description a Gene name Ref gaaC FC gaaC /Ref P value NRRL3_00958 An14g04280 d galacturonic acid transporter GatA gatA 888.35 1062.68 1.20 6.95E02 NRRL3_03144 An12g07500 Exopolygalacturonase 698.90 3384.63 4.84 1.34E02 NRRL3_05260 An02g12450 Exopolygalacturonase Pgx28C pgx28C 99.93 192.85 1.93 9.11E02 NRRL3_05649 An02g07720 2Keto3deoxy l...”
- The transcriptional activator GaaR of Aspergillus niger is required for release and utilization of d-galacturonic acid from pectin
Alazi, FEBS letters 2016 - “...gaaR GA 2h Fold change Ref/ gaaR GA 2h P value GARE (CCNCCAA) position NRRL3_00958 An14g04280 gatA a 888.35 13.32 66.69 1.54E03 +strand 360 NRRL3_08663 An03g01620 GA transporter (putative) a 106.09 30.34 3.50 1.25E01 +strand 673 NRRL3_04281 An07g00780 GA transporter (putative) a 90.41 1.86 48.74 7.77E03...”
- “...Ref SBP 24h gaaR SBP 24h Fold change Ref/ gaaR SBP 24h P value NRRL3_00958 An14g04280 gatA a 849.85 12.60 67.45 6.18E05 1077.70 21.92 49.17 2.84E03 57.92 1.82 31.91 5.06E02 NRRL3_08663 An03g01620 GA transporter (putative) a 2647.36 642.68 4.12 1.01E04 387.81 273.28 1.42 2.41E01 2.69 3.20...”
- Overexpression of the Aspergillus niger GatA transporter leads to preferential use of D-galacturonic acid over D-xylose
Sloothaak, AMB Express 2014 - “...to use this transporter to study D-galacturonic acid metabolism. We have functionally characterized the gene An14g04280 that encodes the D-galacturonic acid transporter in A. niger. In a mixed sugar fermentation it was found that the An14g04280 overexpression strain, in contrast to the parent control strain, has...”
- “...galA poly-galA pectin An07g00780 Major facilitator superfamily strong similarity to monocarboxylate transporter 23.10 9.98 5.27 An14g04280 Major facilitator superfamily strong similarity to hexose transporter 26.53 22.74 27.95 An03g01620 Major facilitator superfamily strong similarity to hexose transporter 6.50 1.345 37.54 In this study we have functionally identified...”
- Conversion of orange peel to L-galactonic acid in a consolidated process using engineered strains of Aspergillus niger
Kuivanen, AMB Express 2014 - “...green I master mix and the LightCycler 96 System. The transcription of putative D-galacturonate transporters An14g04280 and An03g01620 (Martens-Uzunova and Schaap [ 2008 ]) was quantified with the primers listed previously (Kuivanen et al. [ 2012 ]). The transcription levels were normalized to actin using the...”
- “...transport of the substrate into the cell, the transcription of two putative D-galacturonic acid transporters, An14g04280 and An03g01620, was followed by qPCR in the SmFs carried out with gaaB without the nutritional supplementation (Figure 4 ). The transcription of An14g04280 in gaaB did not show any...”
- Identification and characterization of a galacturonic acid transporter from Neurospora crassa and its application for Saccharomyces cerevisiae fermentation processes
Benz, Biotechnology for biofuels 2014 - “...Interestingly, Aspergillus niger only has a clade-2 homolog to GAT-1. However, since the corresponding gene (An14g04280) has been previously shown to be co-regulated with genes involved in pectin degradation and D-GalA catabolism and failed to express in absence of gaaB , the hypothesis of it being...”
- “...forward [ 25 , 45 ]. Additionally, Zhang et al . (2013) recently reported the An14g04280 homolog in Botrytis cinerea ( BcHxt15 ) to be specifically induced by D-GalA and the corresponding mutant to be impaired in growth on D-GalA, which led them to suggest that...”
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GLF_ZYMMO / P21906 Glucose facilitated diffusion protein from Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4) (see 2 papers)
TC 2.A.1.1.4 / P21906 Glucose uniporter from Zymomonas mobilis (see 2 papers)
ZMO0366 sugar transporter from Zymomonas mobilis subsp. mobilis ZM4
33% identity, 90% coverage
- function: Allows uptake of glucose by the cell; allows growth on glucose minimal medium by E.coli cells impaired in glucose transport (PubMed:8144485). Also transports fructose, but has a strong preference for glucose (PubMed:7768841).
- substrates: glucose
- Extension of the substrate utilization range of Ralstonia eutropha strain H16 by metabolic engineering to include mannose and glucose
Sichwart, Applied and environmental microbiology 2011 - “...diffusion transporter (GLF) from Z. mobilis (accession no. P21906); glk, gene encoding the glucokinase (GLK) from E. coli (accession no. NP_416889); mak, gene...”
- Molecular cloning and functional expression in lactobacillus plantarum 80 of xylT, encoding the D-xylose-H+ symporter of Lactobacillus brevis
Chaillou, Applied and environmental microbiology 1998 - “...GlfZ of Z. mobilis (GlfZ-Zm, Swiss-Prot accession number P21906); XylT of B. megaterium (XylT-Bm, EMBL gene bank accession number Z71474); GalP, AraE, and XylE...”
- Major facilitator superfamily
Pao, Microbiology and molecular biology reviews : MMBR 1998 - “...290 491 220 482 419 388 439 451 P09830 P45598 P37021 P21906 P15729 U29579 X86780 P09098 P31578 P54723 U66480 P46333 P42417 P37514 SP SP SP SP SP GB GB SP SP SP...”
- “...norvegicus Th2A of Trypanosoma brucei P37021 P09830 P09098 P21906 P43581 P13181 P11636 P30605 P07921 P15685 S59368 Q07647 U11843 P15686 Q02563 X78855 Q06222 SP...”
- Cloning, functional analysis, and transcriptional regulation of the Bacillus subtilis araE gene involved in L-arabinose utilization
Sá-Nogueira, Journal of bacteriology 1997 - “...sp. (S.sp.), P15729; Glf from Z. mobilis (Z.m.), P21906. VOL. 179, 1997 B. SUBTILIS araE GENE IN L-ARABINOSE UTILIZATION (data not shown), as previously...”
- Characterization and Application of the Sugar Transporter Zmo0293 from Zymomonas mobilis
Zhang, International journal of molecular sciences 2023 - “...a unique facilitated diffusion mediated by the transmembrane transporter Glf (encoded by the glf gene, ZMO0366 ) ( Figure 1 ) [ 21 ]. This facilitator is a low-affinity, high-velocity carrier that does not consume energy. Previous studies have shown that Glf could significantly increase the...”
- “...consistent with previous results [ 28 ]. In addition, it is difficult to delete the ZMO0366 ( glf ) gene by the CRISPR/Cas9 system used in this study and other methods, such as RecET [ 30 ], indicating that this gene is probably an essential gene...”
- Repurposing CRISPR RNA-guided integrases system for one-step, efficient genomic integration of ultra-long DNA sequences
Cheng, Nucleic acids research 2022 - “...glucokinase ( glk ; ZMO0369), fructokinase ( frk ; ZMO1719), glucose facilitator ( glf ; ZMO0366) genes and 30 kb DNA fragment were amplified from the Zymomonas mobilis ZM4. The sucrose metabolism gene clusters ( cscY-cscB-cscA ), the flavin synthesis gene clusters, the violacein synthesis gene...”
- “...( glk ; ZMO0369), fructokinase ( frk ; ZMO1719) and glucose facilitator ( glf ; ZMO0366) genes from Zymomonas mobilis ZM4 under the control of the pcn promoter were introduced into the pDonor plasmid. The glucose facilitator could uptake glucose or fructose into the cytoplasm without...”
- Cellulosic ethanol production by consortia of Scheffersomyces stipitis and engineered Zymomonas mobilis
Sun, Biotechnology for biofuels 2021 - “...185.6-fold at 9h, respectively, compared to S. stipitis mono-fermentation. At the same time, the gene ZMO0366 (glucose facilitated diffusion protein) and ZMO0293 (sugar porter family MFS transporter) came from Z. mobilis also had about 9.9-, 13.6-fold up-regulation at 9h in the consortium (1:3), respectively. These results...”
- Investigation of the impact of a broad range of temperatures on the physiological and transcriptional profiles of Zymomonas mobilis ZM4 for high-temperature-tolerant recombinant strain development
Li, Biotechnology for biofuels 2021 - “...ZMO1572 , and ZMO0806 ), glucose metabolism-related genes ( ZMO1757 , ZMO1756 , ZMO1649 , ZMO0366 , ZMO1981 , and ZMO0689 ), glutamate, histidine, and cysteine synthesis-related genes ( ZMO1117 , ZMO0457 , ZMO1964 , ZMO0783 , ZMO0782 , ZMO0784 ; ZMO0480 , ZMO1105 , ZMO1962...”
- Multiomic Fermentation Using Chemically Defined Synthetic Hydrolyzates Revealed Multiple Effects of Lignocellulose-Derived Inhibitors on Cell Physiology and Xylose Utilization in Zymomonas mobilis
Zhang, Frontiers in microbiology 2019 - “...Mannose uptake from the medium, and subsequent accumulation, likely occurs via facilitated diffusion by Glf (ZMO0366) which, in addition to glucose and xylose, has been shown to aid D -mannose uptake in Z. mobilis ( Weisser et al., 1996 ). Accumulation of mannose sugar phosphates has...”
- “...processing of xylose, or both. Glucose and xylose uptake occur via facilitated diffusion by Glf (ZMO0366). glf expression decreases over the course of our batch fermentations, but glf is not differentially expressed between SynH3 and SynH3 ( Supplementary Tables S1 , S6 ). Higher accumulation of...”
- Identification and Characterization of 5' Untranslated Regions (5'UTRs) in Zymomonas mobilis as Regulatory Biological Parts
Cho, Frontiers in microbiology 2017 - “...ethanol stress Up ZMO1048 Phosphate ABC transporter inner membrane subunit PstC ZMO0140 Protein tyrosine phosphatase ZMO0366 Sugar transporter ZMO1612 Toluene tolerance family protein Given that structural conservation is closely associated with the regulatory roles of RNA (Yang et al., 2010 ), LocARNA was used to determine...”
- Zymomonas mobilis as a model system for production of biofuels and biochemicals
Yang, Microbial biotechnology 2016 - “...pdc (ZMO1360, EC: 4.1.1.1), adhB (ZMO1596, EC:1.1.1.1), extracellular sucrase gene sacC (ZMO0375, EC:3.2.1.26), and glf (ZMO0366, glucose facilitated diffusion protein). For example, the ethanol production module of the fusion enzymes, Pdc and AdhB from Z.mobilis (Part:BBa_K1122673), could increase ethanol yields and productivity in E.coli and lactic...”
- Metabolically engineered glucose-utilizing Shewanella strains under anaerobic conditions
Choi, Bioresource technology 2014 (PubMed)- “...oneidensis MR-1 by introducing the glucose facilitator (glf; ZMO0366) and glucokinase (glk; ZMO0369) genes of Zymomonas mobilis. The engineered MR-1 strain was...”
- “...MR-1 by introducing the glucose facilitator ( glf ; ZMO0366) and glucokinase ( glk ; ZMO0369) genes of Zymomonas mobilis . The engineered MR-1 strain was able...”
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GTR3_MOUSE / P32037 Solute carrier family 2, facilitated glucose transporter member 3; Glucose transporter type 3, brain; GLUT-3 from Mus musculus (Mouse) (see 3 papers)
NP_035531 solute carrier family 2, facilitated glucose transporter member 3 isoform b from Mus musculus
31% identity, 90% coverage
- function: Facilitative glucose transporter (PubMed:35810171). Can also mediate the uptake of various other monosaccharides across the cell membrane (By similarity). Mediates the uptake of glucose, 2- deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate (By similarity). Does not mediate fructose transport (By similarity). Required for mesendoderm differentiation (PubMed:35810171).
catalytic activity: D-glucose(out) = D-glucose(in) (RHEA:60376)
catalytic activity: D-galactose(in) = D-galactose(out) (RHEA:34915)
subunit: Interacts with SMIM43; the interaction may promote SLC2A3- mediated glucose transport to meet the energy needs of mesendoderm differentiation. - LPCAT1 Facilitates Keratinocyte Hyperproliferation and Skin Inflammation in Psoriasis by Regulating GLUT3.
Huang, The Journal of investigative dermatology 2024 (PubMed)- GeneRIF: LPCAT1 Facilitates Keratinocyte Hyperproliferation and Skin Inflammation in Psoriasis by Regulating GLUT3.
- GLUT3 promotes macrophage signaling and function via RAS-mediated endocytosis in atopic dermatitis and wound healing.
Yu, The Journal of clinical investigation 2023 - GeneRIF: GLUT3 promotes macrophage signaling and function via RAS-mediated endocytosis in atopic dermatitis and wound healing.
- Recurrent moderate hypoglycemia accelerates the progression of Alzheimer's disease through impairment of the TRPC6/GLUT3 pathway.
He, JCI insight 2022 - GeneRIF: Recurrent moderate hypoglycemia accelerates the progression of Alzheimer's disease through impairment of the TRPC6/GLUT3 pathway.
- The glucose transporter GLUT3 controls T helper 17 cell responses through glycolytic-epigenetic reprogramming.
Hochrein, Cell metabolism 2022 - GeneRIF: The glucose transporter GLUT3 controls T helper 17 cell responses through glycolytic-epigenetic reprogramming.
- CD205+ polymorphonuclear myeloid-derived suppressor cells suppress antitumor immunity by overexpressing GLUT3.
Fu, Cancer science 2021 - GeneRIF: CD205(+) polymorphonuclear myeloid-derived suppressor cells suppress antitumor immunity by overexpressing GLUT3.
- Adult glut3 homozygous null mice survive to demonstrate neural excitability and altered neurobehavioral responses reminiscent of neurodevelopmental disorders.
Shin, Experimental neurology 2021 - GeneRIF: Adult glut3 homozygous null mice survive to demonstrate neural excitability and altered neurobehavioral responses reminiscent of neurodevelopmental disorders.
- High NOV/CCN3 expression during high-fat diet pregnancy in mice affects GLUT3 expression and the mTOR pathway.
Wang, American journal of physiology. Endocrinology and metabolism 2021 (PubMed)- GeneRIF: High NOV/CCN3 expression during high-fat diet pregnancy in mice affects GLUT3 expression and the mTOR pathway.
- Developing Brain Glucose Transporters, Serotonin, Serotonin Transporter, and Oxytocin Receptor Expression in Response to Early-Life Hypocaloric and Hypercaloric Dietary, and Air Pollutant Exposures.
Ye, Developmental neuroscience 2021 - GeneRIF: Developing Brain Glucose Transporters, Serotonin, Serotonin Transporter, and Oxytocin Receptor Expression in Response to Early-Life Hypocaloric and Hypercaloric Dietary, and Air Pollutant Exposures.
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- Proteomic analysis reveals activation of platelet- and fibrosis-related pathways in hearts of ApoE-/- mice exposed to diesel exhaust particles.
Jung, Scientific reports 2023 - “...TGFB1 Transforming growth factor beta-1 proprotein 1.88 0.034 O08742 GP5 Platelet glycoprotein V 1.87 0.035 P32037 SLC2A3 Solute carrier family 2, facilitated glucose transporter member 3 1.77 0.008 Q07235 SERPINE2 Glia-derived nexin 1.75 0.018 P12399 CTLA2A Protein CTLA-2-alpha 1.75 0.018 Q8BTM8 FLNA Filamin-A 1.67 0.030 P41317...”
- Unraveling the Proteomic Landscape of Intestinal Epithelial Cell-Derived Exosomes in Mice.
Ding, Frontiers in physiology 2022 - “...0.735 0.083 Not 12 Q5DTL9 Slc4a10 Sodium-driven chloride bicarbonate exchanger 39.14 0.734 0.025 Down 13 P32037 Slc2a3 Solute carrier family 2, facilitated glucose transporter member 3 25.83 0.734 0.227 Not 14 Q8VEM8 Slc25a3 Phosphate carrier protein, mitochondrial 250.32 0.732 0.000 Down 15 Q9Z2J0 Slc23a1 Solute carrier...”
- miR-29a/b1 Regulates the Luteinizing Hormone Secretion and Affects Mouse Ovulation
Guo, Frontiers in endocrinology 2021 - “...P01216 Cga Glycoprotein hormones alpha chain OS=Mus musculus GN=Cga PE=2 SV=1 14 kDa 0.00035 1.35 P32037 Slc2a3 Solute carrier family 2, facilitated glucose transporter member 3 OS=Mus musculus GN=Slc2a3 PE=1 SV=1 53 kDa < 0.0001 1.35 Q8VCT4 Ces1d Carboxylesterase 1D OS=Mus musculus GN=Ces1d PE=1 SV=1 62...”
- Proteomics Landscape of Host-Pathogen Interaction in Acinetobacter baumannii Infected Mouse Lung
Li, Frontiers in genetics 2021 - “...P27870 Vav1 Vav 1 oncogene 1.22 1.66 P50404 Sftpd Surfactant associated protein D 1.35 1.56 P32037 Slc2a3 Solute carrier family 2 (facilitated glucose transporter), member 3 1.36 1.53 Q8BND5 Qsox1 Quiescin Q6 sulfhydryl oxidase 1 1.29 1.42 Q3U2S8 Hvcn1 Hydrogen voltage-gated channel 1 1.60 1.35 P28033...”
- The Impacts of Surgery and Intracerebral Electrodes in C57BL/6J Mouse Kainate Model of Epileptogenesis: Seizure Threshold, Proteomics, and Cytokine Profiles
Tse, Frontiers in neurology 2021 - “...3.6494 0.00901 17.52368 19.70244 18.78533 19.755233 Proteins downregulated in both surgery groups (vehicle and KA) P32037 Solute carrier family 2-(Glucose transporter type 3, brain) (GLUT-3) Slc2a3 Glut3 24.736 0.00002 4.6986 0.00191 22.52552 22.390868 22.63737 22.245415 Q62283 Tetraspanin-7 (Tspan-7/CD antigen CD231) Tspan7 Mxs1 21.247 4.31E-05 4.3654 0.00347...”
- Environmental Enrichment Upregulates Striatal Synaptic Vesicle-Associated Proteins and Improves Motor Function
Song, Frontiers in neurology 2018 - “...carboxyl-terminal hydrolase USP9X 1.51 O70161-3 Isoform 3 of Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma PIP5K1C 1.51 P32037 Solute carrier family 2, facilitated glucose transporter member 3 SLC2A3 1.51 Q91ZA3 Propionyl-CoA carboxylase alpha chain, mitochondrial PCCA 1.51 E9Q035 Protein Gm20425 GM20425 1.51 Q7TMY8-4 Isoform 4 of E3 ubiquitin-protein...”
- Major facilitator superfamily
Pao, Microbiology and molecular biology reviews : MMBR 1998 - “...P20303 S37476 P11168 P14246 P12336 P47842 P28568 P11169 P32037 P47843 Q07647 P14672 P14142 P19357 P22732 P46408 P43427 Q00712 B30310 U39197 U29377 U43375 U52842...”
TRE12_DROME / Q8MKK4 Facilitated trehalose transporter Tret1-2 homolog; DmTret1-2 from Drosophila melanogaster (Fruit fly) (see paper)
34% identity, 80% coverage
MST4_ORYSJ / Q10PW9 Sugar transport protein MST4; Monosaccharide transporter 4; OsMST4; Sugar:proton symporter MST4 from Oryza sativa subsp. japonica (Rice) (see 2 papers)
31% identity, 86% coverage
- function: Mediates active uptake of hexoses by sugar:proton symport (Probable). Can transport glucose, fructose, mannose and galactose (PubMed:17874189, PubMed:18506478). Can transport xylose and ribose (PubMed:18506478).
K7TK04 Carbohydrate transporter/ sugar porter from Zea mays
31% identity, 87% coverage
- Key factors identified by proteomic analysis in maize (Zea mays L.) seedlings' response to long-term exposure to different phosphate levels
Sun, Proteome science 2018 - “...Purple acid phosphatase 2.03 1.67 0.62 Carbohydrate transporters C0PHL2 Monosaccharide transporter 1 1.72 1.33 0.83 K7TK04 Carbohydrate transporter/ sugar porter 4.655 0.61 A0A1D6EP34 Sugar transport protein 14 1.4 0.78 B6TZY0 Facilitated glucose transporter member 8 1.38 0.77 ABC transporters A0A1D6NEN5 ABC transporter B family member 9...”
- “...patterns under LP and HP conditions (Table 2 ). For carbohydrate transporters, C0PHL2 (monosaccharide transporter1), K7TK04 (carbohydrate transporter/sugar porter), A0A1D6EP34 (sugar transport protein 14) and B6TZY0 (facilitated glucose transporter member 8), were increased under LP condition but suppressed under HP condition in the leaves or roots,...”
M1D4R5 Hexose transporter from Solanum tuberosum
32% identity, 82% coverage
- Enhanced stress resilience in potato by deletion of Parakletos
Zahid, Nature communications 2024 - “...M1B1N5 Chlorophyll a-b binding protein 2.4 Q2XPW1 Histone H2B 2.3 M1CN16 Transcription factor RF2b 2.2 M1D4R5 Hexose transporter 2.1 M1C8J8 3-oxoacyl-CoA synthase 2 M1BS09 Poly(RC)-binding protein 2 M0ZNA1 Pre-mRNA-splicing factor cwc23 1.9 Functional test of candidate proteins identifies Parakletos To assess the functional significance of the...”
Q102R8 Glucose transporter 2 from Danio rerio
NP_001036186 solute carrier family 2, facilitated glucose transporter member 2 from Danio rerio
30% identity, 88% coverage
TC 2.A.1.1.103 / Q0WWW9 D-xylose-proton symporter-like 3, chloroplastic from Arabidopsis thaliana (see 7 papers)
NP_200733 Major facilitator superfamily protein from Arabidopsis thaliana
AT5G59250 sugar transporter family protein from Arabidopsis thaliana
32% identity, 78% coverage
- substrates: Xylose
- The Plastidic Sugar Transporter pSuT Influences Flowering and Affects Cold Responses.
Patzke, Plant physiology 2019 - GeneRIF: PSuT(At5g59250) mediated sucrose export out of chloroplasts modulates abiotic stress tolerance in Arabidopsis, as demonstrated by the impaired response of mutants to cold temperatures.
- Functional survey for heterologous sugar transport proteins, using Saccharomyces cerevisiae as a host
Young, Applied and environmental microbiology 2011 - “...Q6BTD8 Q2MEV7 GXS1 DEHA0D02167 Q2MDH1 Q6AWX0 At5g17010 GXF1 Q0WWW9 P22144 At5g59250 P31867 XYL2 UniProt accession no. XYL1 Gene/locus tag E. coli D. hansenii C....”
- Optimizing pentose utilization in yeast: the need for novel tools and approaches
Young, Biotechnology for biofuels 2010 - “...TMB3201 - Arabidopsis thaliana Stp3 Q8L7R8 p4H7 [ 64 ] TMB3201 - Arabidopsis thaliana At5g59250 Q0WWW9 p4H7 [ 64 ] TMB3201 - Arabidopsis thaliana At5g59250 Q0WWW9 pRH145 [ 75 ] BY4727 + Arabidopsis thaliana At5g17010 Q6AWX0 pRH145 [ 75 ] BY4727 + Arabidopsis thaliana Seedling cDNA...”
- An atlas of rational genetic engineering strategies for improved xylose metabolism in Saccharomyces cerevisiae
Vargas, PeerJ 2023 - “.../ XKS1 25% and 40% increase in xylose consumption ( Hector et al., 2008 ) AT5G59250 ( Arabidopsisthaliana) AT5G59250 ( Arabidopsis thaliana) Scheffersomyces stipitisXYL1 (K270R) and XYL2 / XKS1 / TAl1 / TKL1 / RPK1 / RPE1 / gre3 Did not present significant results in the...”
- “...Reis et al., 2016 ). In Arabidopsis thaliana , genes encoding sugar transporters AT5G17010 and At5g59250 were expressed in recombinant S. cerevisiae containing the genetic modifications for xylose consumption, and the consumption of this pentose was analyzed in fermentations. Strains expressing the AT5G17010 and AT5G59250 transporters...”
- The novel chloroplast glucose transporter pGlcT2 affects adaptation to extended light periods
Valifard, The Journal of biological chemistry 2023 - “...genes in plant species Alignment of pGlcT2 with other sugar transporters (VGT1: At3g03090 , pSUT: At5g59250 , and pGLCT: At5g16150 ) was done using MEGA11 software ( 74 ) based on ClustalW ( 75 ) alignment of the corresponding amino acid sequences. The alignment was visualized...”
- Valorisation of xylose to renewable fuels and chemicals, an essential step in augmenting the commercial viability of lignocellulosic biorefineries
Narisetty, Sustainable energy & fuels 2021 - “...by 25 and 40% with the introduction of Arabidopsis thaliana xylose transporter genes At5g17010 and At5g59250 , respectively. 192 A large improvement (75%) in xylose transport was achieved with Gxf1 , a MFS transporter identified from Candida intermedia . 193 This traditional xylose transporter displayed improved...”
- Membrane transporters in the bioproduction of organic acids: state of the art and future perspectives for industrial applications
Soares-Silva, FEMS microbiology letters 2020 - “...Xyp29 ( STL12 ), SUT3 (Xyp37) from Scheffersomyces stipitis , GXF1 from Candida intermedia , At5g59250 from Arabidopsis thaliana , An292 and An25 from Neurospora crassa , xtrD from A. nidulans , MgT05196 from Meyerozyma guilliermondii and Xylh from Debaryomyces hansenii . More than 80% of...”
- Engineering of sugar transporters for improvement of xylose utilization during high-temperature alcoholic fermentation in Ogataea polymorpha yeast
Vasylyshyn, Microbial cell factories 2020 - “...Xyp29 (STL12), Sut3 (Xyp37) from Scheffersomyces stipitis , Gxs1 and Gxf1 from Candida intermedia , At5g59250 from Arabidopsis thaliana , An29-2 and An25 from Neurospora crassa , xtrD from Aspergillus nidulans , MgT05196 from Meyerozyma guilliermondii and Xylh from Debaryomyces hansenii restored the ability of S....”
- Novel xylose transporter Cs4130 expands the sugar uptake repertoire in recombinant Saccharomyces cerevisiae strains at high xylose concentrations
Bueno, Biotechnology for biofuels 2020 - “...to other known heterologous xylose transporters, such as Sut1, Xut1, Xut3 ( Scheffersomyces stipitis ), At5g59250 ( Arabidopsis thaliana ) and XylHP ( Debaryomyces hansenii ) [ 21 , 26 , 33 ]. Interestingly, the transport of xylose in Gxf1 seems to be concentration-dependent given that...”
- “...to restore significant xylose growth on expressing strains. Even A. thaliana xylose transporters, At5g17010 and At5g59250, were responsible for 25% and 40% of improvements in xylose consumption rate, respectively, on S. cerevisiae strains [ 57 ]. As highlighted above, the facilitator Gxf1 isolated from C. intermedia...”
- The Plastidic Sugar Transporter pSuT Influences Flowering and Affects Cold Responses
Patzke, Plant physiology 2019 (PubMed)- “...data libraries under accession numbers BT015354.1 (pSUT, At5g59250), BT010375.1 584 Plant Physiol. Vol. 179, 2019 Downloaded from on August 13, 2019...”
- Engineering of Pentose Transport in Saccharomyces cerevisiae for Biotechnological Applications
Nijland, Frontiers in bioengineering and biotechnology 2019 - “...(Hector et al., 2008 ). In a comparative analysis of various heterologously expressed sugar transporters, At5g59250 showed only a slight improvement in the D-xylose uptake kinetics employing a strain harboring the native Hxt landscape, but this result was not statistically significant. In contrast, the aforementioned Ci...”
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ATEG_07144 uncharacterized protein from Aspergillus terreus NIH2624
30% identity, 83% coverage
- Transcriptome Profiling-Based Analysis of Carbohydrate-Active Enzymes in Aspergillus terreus Involved in Plant Biomass Degradation
Corrêa, Frontiers in bioengineering and biotechnology 2020 - “...SH during the 48 h incubation period, namely ATEG_07791, ATEG_03475, ATEG_07105, ATEG_04988, ATEG_01556, ATEG_07124, ATEG_08653, ATEG_07144, ATEG_03527, ATEG_02489, ATEG_07114, ATEG_04070, ATEG_07053, ATEG_04137, ATEG_03190, and ATEG_05008. RT-qPCR Validation of in silico RNA-Seq Transcriptome Data Expression profiles for selected A. terreus CAZyme-encoding and other genes significantly up-regulated on...”
INT3_ARATH / Q9ZQP6 Probable inositol transporter 3 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
AT2G35740 INT3 (NOSITOL TRANSPORTER 3); carbohydrate transmembrane transporter/ sugar:hydrogen symporter from Arabidopsis thaliana
36% identity, 54% coverage
- function: Plasma membrane inositol-proton symporter.
- The Arabidopsis altered in stress response2 is Impaired in Resistance to Root and Leaf Necrotrophic Fungal Pathogens
Thatcher, Plants (Basel, Switzerland) 2019 - “...narrowed to four candidate loci. disease susceptibility GSTF8 necrotroph jasmonate At2g31320 At2g31400 At2g31990 At2g33170 At2g35170 At2g35740 At2g36420 At2g36835 At5g53060 CPL1 At4g21670 1. Introduction Crop damage caused by pathogen and pest attack costs the global economy billions of dollars annually, with the Food and Agriculture Organization of...”
- “...Exostosin family protein, At2g33170 a Leucine-rich repeat receptor-like protein, At2g35170 a Histone H3 K4-specific methyltransferase, At2g35740 NOSITOL TRANSPORTER 3 ( ATINT3/INT3 ), At2g36420 TON1 RECRUITING MOTIF 27 ( TRM27 ), and At2g36835 an unknown protein. We undertook the same genetic complementation studies used to clone the...”
- Species-Wide Variation in Shoot Nitrate Concentration, and Genetic Loci Controlling Nitrate, Phosphorus and Potassium Accumulation in Brassica napus L
Alcock, Frontiers in plant science 2018 - “...concentration Bo4g185840.1 AT2G38940 4 10 116 PHOSPHATE TRANSPORTER 1.4 C4 Bo4g182560.1:642:G Leaf P concentration Bo4g184590.1 AT2G35740 6 10 137 INOSITOL TRANSPORTER 3 C4 Bo4g182560.1:642:G Leaf P concentration Bo8g108330.1 AT1G12240 0.0 BFRUCT4; plays a role in mobilizing sucrose to sink organs and in root elongation C8 Bo8g108620.1:687:A...”
- The paralogous R3 MYB proteins CAPRICE, TRIPTYCHON and ENHANCER OF TRY AND CPC1 play pleiotropic and partly non-redundant roles in the phosphate starvation response of Arabidopsis roots
Chen, Journal of experimental botany 2015 - “...controlled by CPC, ETC1 and TRY Antisense gene Overlaps with Description Fold-change etc1 Pi-replete At2g35738 At2g35740 INOSITOL TRANSPORTER 3 (INT3) 0.52 etc1 low Pi At1g74205 At1g74210 GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE 5 (GDPD5) 1.69 At4g26795 At4g26790 GDSL-like lipase/acylhydrolase superfamily protein 2.18 At1g60505 At1g60510 DYNAMIN RELATED PROTEIN 4D (DRP4D) 1.90...”
- “...cpc Pi-replete At1g72852 At1g72850 Disease resistance protein 0.42 At1g67365 At1g67370 ASYNAPTIC 1 (ASY1) 0.33 At2g35738 At2g35740 INOSITOL TRANSPORTER 3 (INT3) 0.35 At5g07152 At5g07150 Leucine-rich repeat protein kinase family protein 2.42 cpc low Pi At4g27852 At4g27850; At4g27860 Glycine-rich protein family; MEMBRANE OF ER BODY 1 (MEB1) 0.35...”
- Sucrose phosphate synthase and sucrose phosphate phosphatase interact in planta and promote plant growth and biomass accumulation
Maloney, Journal of experimental botany 2015 - “...tagged with hRLUC in N- and C-terminal orientations (SPS R and R SPS), and AtSPP (At2g35740) was tagged with YFP at the C-terminus (SPP Y ). The Arabidopsis ubiqutin5 gene was used as an internal control, and results are given as relative transgene transcript abundance. AtSPPSPS...”
- The Vitis vinifera sugar transporter gene family: phylogenetic overview and macroarray expression profiling
Afoufa-Bastien, BMC plant biology 2010 - “...for Arabidopsis thaliana transporters are: At1g20840 (AtTMT1), At4g35300 (AtTMT2), At3g51490 (AtTMT3), At2g43330 (AtINT1), At1g30220 (AtINT2), At2g35740 (AtINT3), At4g16480 (AtINT4), At3g03090 (AtVGT1), At5g17010 (AtVGT2), At5g59250 (AtVGT3), At2g16120 (AtPMT1), At2g16130 (AtPMT2), At2g18480 (AtPMT3), At2g20780 (AtPMT4), At3g18830 (AtPMT5), At4g36670 (AtPMT6); for Vitis ones see Additional file 1 . Vitis...”
- Localization of myo-inositol-1-phosphate synthase to the endosperm in developing seeds of Arabidopsis
Mitsuhashi, Journal of experimental botany 2008 - “...3 kinase. The following primer sets were used for RT-PCR, AtITR1 (At4g16480) 5-GCATGTCTTATCATCTTAGCCACG-3, 5-GCCCCAAAAACACTATAGCTAAGA-3, AtITR2 (At2g35740) 5-ACTTGCCTTGTCATTTTGGCT-3 and 5-AAGGAAGACAATGGCCAGGT-3, AtITR3 (At2g43330) 5-GATAGTCCAAATGGCTGGATTTC-3 and 5-CTAAGCCAAGCACAGCGAG-3, AtITR4 (At1g30220) 5-CATTATCTCGCTAGGAATACTAACCG-3 and 5-GTCCCAATCCAAGAAGAGCA-3, PPK1 (At5g16760) 5-TCGAACACTCAAGGCAACGA-3 and 5-TCCGGGACACCAAATCTCTC-3, PPK2 (At4g08170) 5-CCGGAGGCTGTCAATAATGC-3 and 5-CACAAGAGACCCGTGGGAAG-3, PPK3 (At4g33770) 5-GCAGACTTGGACCCTCGTGT-3 and 5-TTTGACCTGCGCCAGATTTT-3, AtIPK2 (At5g07370)...”
GTR10_DANRE / F1R0H0 Solute carrier family 2, facilitated glucose transporter member 10; Glucose transporter type 10; GLUT-10 from Danio rerio (Zebrafish) (Brachydanio rerio) (see 2 papers)
XP_005172836 solute carrier family 2, facilitated glucose transporter member 10 isoform X1 from Danio rerio
31% identity, 83% coverage
SS1G_03579 hypothetical protein from Sclerotinia sclerotiorum 1980 UF-70
33% identity, 81% coverage
STP11_ARATH / Q9FMX3 Sugar transport protein 11; Hexose transporter 11 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
TC 2.A.1.1.61 / Q9FMX3 High affinity monosaccharide (Km = 25 µM) transporter (takes up glucose, galactose, mannose, xylose and 3-O-methylglucose, but not fructose and ribose), STP11 (expressed in pollen tubes) from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
stp11 / CAC69075.1 STP11 protein from Arabidopsis thaliana (see paper)
NP_197718 sugar transporter 11 from Arabidopsis thaliana
AT5G23270 STP11 (SUGAR TRANSPORTER 11); carbohydrate transmembrane transporter/ sugar:hydrogen symporter from Arabidopsis thaliana
31% identity, 85% coverage
- function: Mediates an active uptake of hexoses, probably by sugar/hydrogen symport. Can transport glucose, galactose, mannose, xylose and 3-O-methylglucose, but not fructose and ribose.
- substrates: Sugars
tcdb comment: This protein is also called Sugar Transport Protein (STP). Expression profiles of homologues in cabbage have been studied (Zhang et al. 2019) - AtSTP11, a pollen tube-specific monosaccharide transporter in Arabidopsis.
Schneidereit, Planta 2005 (PubMed)- GeneRIF: AtSTP11 transporter plays a role in the supply of monosaccharides to growing pollen tubes. [AtSTP11]
- Do mitochondria use efflux pumps to protect their ribosomes from antibiotics?
Islam, Microbiology (Reading, England) 2023 - “...MFS G1UAY0, 2.3E^6 Q56ZZ7, 2.3E^7 Q8NBP5, 8.4E^9 [ 78 ] NCU10021 Q7S0I5 MFS Q8J2J7, 8.1E^102 Q9FMX3, 2.3E^55 Q96QE2, 2.8E^41 [ 78 ] *Information gathered from NCBI Protein BLAST, algorithm: PSI-BLAST ( https://www.ncbi.nlm.nih.gov/ ) and HMMER phmmer, Database: Reference Proteomes ( http://hmmer.org/ ) . The accession code...”
- Genome-wide identification, expression, and association analysis of the monosaccharide transporter (MST) gene family in peanut (Arachis hypogaea L.)
Wan, 3 Biotech 2020 - “...arsenic accumulation AhMST16 AhMST41 AhMST54 AhMST69 AtSTP11 (AT5G23270) STP12 (AT4G21480) AtINT2 (AT1G30220) AtPMT1 (AT2G16120) Stadler et al. (2003), Sherson...”
- Plant glucose transporter structure and function
Geiger, Pflugers Archiv : European journal of physiology 2020 - “...pollen Plasma membrane Glucose, galactose, mannose, High [ 109 , 122 , 124 ] AtSTP11 At5g23270 Fully mature pollen and growing pollen tubes Plasma membrane Glucose, galactose, mannose, xylose, arabinose High [ 122 , 132 ] AtSTP12 At4g21480 Multiple tissues except pollen Plasma membrane Glucose, galactose,...”
- Genome-Wide Identification and Expression Profiling of Sugar Transporter Protein (STP) Family Genes in Cabbage (Brassica oleracea var. capitata L.) Reveals their Involvement in Clubroot Disease Responses
Zhang, Genes 2019 - “...Bol000549 Scaffold000531 MF1 1536 511 56.16 8.60 30.51 97.50 0.48 cell membrane tPCK7 Q AtSTP11 AT5G23270 1545 514 BoSTP11 Bol017091 C06 LF 1569 522 57.17 5.79 33.58 105.50 0.55 cell membrane Clade III tPCK1 A AtSTP2 AT1G07340 1497 498 BoSTP2a Bol023380 C08 MF1 1497 498 55.48...”
- The Arabidopsis KH-Domain RNA-Binding Protein ESR1 Functions in Components of Jasmonate Signalling, Unlinking Growth Restraint and Resistance to Stress
Thatcher, PloS one 2015 - “...1.0E-02 mitochondrial editing factor 20 AT1G20080 SYTB 7.60 1.1E-02 Calcium-dependent lipid-binding (CaLB domain) family protein AT5G23270 STP11 6.74 1.2E-02 sugar transporter 11 AT2G19910 2.15 1.3E-02 RNA-dependent RNA polymerase family protein AT3G47090 2.09 1.5E-02 Leucine-rich repeat protein kinase family protein AT5G38040 2.15 1.8E-02 UDP-Glycosyltransferase superfamily protein AT5G23600...”
- Floral heteromorphy in Primula vulgaris: progress towards isolation and characterization of the S locus
Li, Annals of botany. 2011 - “...AT1G77390 2e-25 9e-24 82I1-R 28H15-F 2 2 AT1G21640 AT5G23270 1e-35 3e-37 28H15-R 2 AT1G74720 1e-97 17A21-R 81I19-F 3 3 AT2G04280 AT4G29090 4e-60 4e-30 56H19-R...”
- The Vitis vinifera sugar transporter gene family: phylogenetic overview and macroarray expression profiling
Afoufa-Bastien, BMC plant biology 2010 - “...(AtSTP3), At3g19930 (AtSTP4), At1g34580 (AtSTP5), At3g05960 (AtSTP6), At4g02050 (AtSTP7), At5g26250 (AtSTP8), At1g50310 (AtSTP9), At3g19940 (AtSTP10), At5g23270 (AtSTP11), At4g21480 (AtSTP12), At5g26340 (AtSTP13), At1g77210 (AtSTP14); for Vitis ones see Additional file 1 . Vitis vinifera putative Tonoplast Monosaccharide Transporters (VvTMT; subfamily II) We have also identified three ORFs,...”
- Gene expression in developing fibres of Upland cotton (Gossypium hirsutum L.) was massively altered by domestication
Rapp, BMC biology 2010 - “...4 column 2, row 5 of the transition matrix, the cotton genes are homologous to At5g23270 ( AtFER1 ). As reviewed recently [ 62 ], wide expression of AtFER1 in Arabidopsis supports the regulation of iron concentration and the moderation of ROS levels in response to...”
TC 2.A.1.1.20 / Q01440 Myoinositol:H+ symporter, MIT from Leishmania donovani (see paper)
32% identity, 79% coverage
- substrates: myo-inositol
- Predictive classification models and targets identification for betulin derivatives as Leishmania donovani inhibitors
Zhang, Journal of cheminformatics 2018 - “...%Identity Evalue Bit score Query P27890 HSP83_LEIDO Heat shock protein 83 61.76 0 568 P07900|HS90A_HUMAN Q01440 GTR1_LEIDO Membrane transporter D1 34.83 0.004 30.8 P21616|AVP_VIGRR A4ZZ93 DHYSL_LEIDO Inactive deoxyhypusine synthase 19.70 0.042 26.2 P42330|AK1C3_HUMAN P39050 TYTR_LEIDO Trypanothione reductase 64.71 0.051 27.7 P11362|FGFR1_HUMAN E9BDA8 GMPR_LEIDB GMP reductase 25.64...”
- Major facilitator superfamily
Pao, Microbiology and molecular biology reviews : MMBR 1998 - “...brucei brucei 547 558 543 567 544 528 529 527 337 Q01440 Q01441 L47540 P13865 U05588 Q09037 Q06222 Q06221 Q09039 SP SP GB SP GB SP SP SP SP Ag1 Sce Gal2...”
XP_005201725 solute carrier family 2, facilitated glucose transporter member 2 isoform X1 from Bos taurus
31% identity, 80% coverage
NP_001261233 glucose transporter 1, isoform R from Drosophila melanogaster
32% identity, 53% coverage
LOC8155361 sugar transport protein 1 from Sorghum bicolor
30% identity, 84% coverage
- Transcriptome analysis of the impact of exogenous methyl jasmonate on the opening of sorghum florets
Liu, PloS one 2021 - “...GTACCCTCCTGGTCACTGCTC AACCACCTTGTTTCCCCTGAT 14 LOC110429834 TTACCTCTCGTTGACACCATC CACACCACATCCTTGCTTTAG 15 LOC8056099 ATTTGGGACCAGGCAGACATT GAGCACCAACAAACGCATCAC 16 LOC8083790 TAGCAAAAGATGTCAGTTTCAAGG GTAATCCCATCGTATTCTTCCAAAA 17 LOC8155361 CCACTTCAAGTTCGGCCTCTT AACCAGTGGGACTTCCAGACG Functional pathway analysis of DEGs Based on the results of DEGs detection, biological pathway classification and enrichment analysis was performed in KEGG. Total of 29,135 unigenes were used...”
U3IRP7 Solute carrier family 2 member 2 from Anas platyrhynchos platyrhynchos
34% identity, 78% coverage
STP9_ARATH / Q9SX48 Sugar transport protein 9; Hexose transporter 9 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
stp9 / CAC69072.1 STP9 protein from Arabidopsis thaliana (see paper)
AT1G50310 STP9 (SUGAR TRANSPORTER 9); carbohydrate transmembrane transporter/ sugar:hydrogen symporter from Arabidopsis thaliana
30% identity, 85% coverage
- function: Mediates an active uptake of hexoses, probably by sugar/hydrogen symport. Mostly transports glucose, and barely galactose, xylose and mannose.
- Exploration of Sugar and Starch Metabolic Pathway Crucial for Pollen Fertility in Rice
Lee, International journal of molecular sciences 2022 - “...the hexose transporters resulted in male sterility. A T-DNA insertion mutant of Arabidopsis AtSTP9 ( At1g50310 ), a monosaccharide transporter that is expressed specifically in pollen, was not male-sterile [ 20 ]. A group of SWEET efflux transporters is also involved in the capability of transporting...”
- Rho GTPase ROP1 Interactome Analysis Reveals Novel ROP1-Associated Pathways for Pollen Tube Polar Growth in Arabidopsis
Li, International journal of molecular sciences 2020 - “...transporters were found for transmembrane trafficking of nutrients and energy, such as STP4&STP9 (AT3G19930 and AT1G50310) for sucrose and AT1G71680 for amino acids. 3.4. ROP1 Signaling and Endocytosis Exocytosis of secretory vesicles is critical for pollen tube expansion by supplying membrane, cell wall components, and other...”
- Plant glucose transporter structure and function
Geiger, Pflugers Archiv : European journal of physiology 2020 - “...and ovules Plasma membrane Glucose, galactose, mannose, arabinose High [ 122 , 123 ] AtSTP9 At1g50310 Fully developed pollen grain Plasma membrane Glucose, galactose, arabinose High [ 122 , 131 ] AtSTP10 At3g19940 Germinating pollen and growing pollen Plasma membrane Glucose, galactose, mannose, High [ 109...”
- Genome-Wide Identification and Expression Profiling of Sugar Transporter Protein (STP) Family Genes in Cabbage (Brassica oleracea var. capitata L.) Reveals their Involvement in Clubroot Disease Responses
Zhang, Genes 2019 - “...Bol000550 Scaffold000531 MF1 1545 514 56.99 8.99 38.20 102.80 0.56 cell membrane tPCK1 C AtSTP9 AT1G50310 1554 517 BoSTP9a Bol010165 C07 LF 1551 516 56.27 6.89 32.15 99.01 0.53 cell membrane BoSTP9b Bol014014 Scaffold000180 MF2 1551 516 56.15 6.89 33.77 101.67 0.54 cell membrane tPCK2 F...”
- Modulation of Auxin Levels in Pollen Grains Affects Stamen Development and Anther Dehiscence in Arabidopsis
Salinas-Grenet, International journal of molecular sciences 2018 - “...STP2 , At1g07340), intermediate pollen promoter 1 (from the sugar transporter 9 gene, STP9 , At1g50310), intermediate pollen promoter 2 (from the pollen-specific gene 2 gene, PSG2 , At1g28550), and late pollen promoter (from the phosphatase and tensin homolog deleted on chromosome 10 gene, PTEN1 ,...”
- Analysis of miRNAs and their targets during adventitious shoot organogenesis of Acacia crassicarpa
Liu, PloS one 2014 - “...superfamily protein MIR2592 AT4G11040 3 Protein phosphatase 2C family protein MIR2916 AT1G15780 3 unknown protein AT1G50310 3 sugar transporter 9 AT1G65875 3 pseudogene AT1G66120 3 AMP-dependent synthetase and ligase family protein AT4G00450 3 RNA polymerase II transcription mediators AT5G66710 3 Protein kinase superfamily protein MIR4414 AT2G04860...”
- The pectin lyases in Arabidopsis thaliana: evolution, selection and expression profiles
Cao, PloS one 2012 - “...AT1G23460 had 36 ( Table S3 ). Some of these interacting genes include AtSTP9 ( AT1G50310 ), IRT1 ( AT5G43370 ), AT3G09820 ( ADK1 , adenosine kinase 1), LOS2 ( AT2G36530 ), and flagellin-sensitive 2 ( FLS2 , AT5G46330 ). AtSTP9 encodes a member of sugar...”
- Proline is required for male gametophyte development in Arabidopsis
Mattioli, BMC plant biology 2012 - “...is high at tricellular stage and low in mature pollen [ 35 ] and AtSTP9 (AT1G50310), whose gene product can only be detected by immunofluorescence microscopy after the onset of germination [ 36 ]. In addition, as above stated, high levels of expression of either P5CS1...”
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NP_850483 Major facilitator superfamily protein from Arabidopsis thaliana
AT2G48020, NP_850483 sugar transporter, putative from Arabidopsis thaliana
33% identity, 95% coverage
- Intron retention in the 5'UTR of the novel ZIF2 transporter enhances translation to promote zinc tolerance in arabidopsis.
Remy, PLoS genetics 2014 - GeneRIF: Findings indicate that alternative splicing controls the levels of a Zn-responsive mRNA variant of the ZIF2 transporter to enhance plant tolerance to the metal ion. [ZIF2]
- Transcriptional landscape of cotton roots in response to salt stress at single-cell resolution
Li, Plant communications 2023 - Black sheep, dark horses, and colorful dogs: a review on the current state of the Gene Ontology with respect to iron homeostasis in Arabidopsis thaliana
Mai, Frontiers in plant science 2023 - “...compounds that are in the context of iron homeostasis. Family AGI locus identifiers (symbols) ZIF/ZIFL AT2G48020 ( ZIF1 ) At3G43790 ( ZIF2 ) AT5G13740 ( ZIFL1 ) AT5G13750 ( ZIFL2 ) MTP AT2G46800 ( MTP1 ) AT3G61940 ( MTP2 ) AT3G58810 ( MTP3 ) AT2G29410 (...”
- Response of the organellar and nuclear (post)transcriptomes of Arabidopsis to drought
Xu, Frontiers in plant science 2023 - “...AT4G20380 see above LSD1 AT2G18790 see above PHYB AT1G29900 CARBAMOYL PHOSPHATE SYNTHETASE B CARB; VEN3 AT2G48020 ZINC-INDUCED FACILITATOR 2 ZIF2 AT1G04080 Pre-mRNA processing protein PRP39A AT1G77080 FLOWERING LOCUS M; MADS domain protein; flowering regulator that is closely related to FLC; see also main text FLM AT1G09140...”
- Transcriptome analysis of Pará rubber tree (H. brasiliensis) seedlings under ethylene stimulation
Nakano, BMC plant biology 2021 - “...AT2G18480 AtPLT3 6.25 6.26 6.34 Putative monosaccharide transporter family (ERD-group=induced by early dehydration) 0 bx021636 AT2G48020 Major facilitator superfamily protein 2.01 2.93 2.45 0 bx037209 AT2G48020 Major facilitator superfamily protein 2.01 2.98 2.49 2 bx019596 AT3G05160 Major facilitator superfamily protein 1.84 2.66 1.41 Sucrose-proton symporter, SUS,...”
- Early Response to Dehydration Six-Like Transporter Family: Early Origin in Streptophytes and Evolution in Land Plants
Slawinski, Frontiers in plant science 2021 - “...names ESL1 B1a At1g19450 AtERD6-Like 4 ESL1.01 ESL1 B1b At1g75220 AtERD6-Like 6 ESL1.02/ERDL6 ESL2a B2 At2g48020 AtERD6-Like 7 ESL2.01/ZIF2 ESL2a B3 At3g05150 AtERD6-Like 8 ESL2.02 ESL2b B4 At5g18340 AtERD6-Like 16 ESL2.03 ESL3a B5 At1g54730 AtERD6-Like 5 ESL3.01 ESL3b B6a At4g04750 AtERD6-Like 14 ESL3.02 ESL3b B6b At4g04760...”
- Responsiveness of Early Response to Dehydration Six-Like Transporter Genes to Water Deficit in Arabidopsis thaliana Leaves
Slawinski, Frontiers in plant science 2021 - “...PCR Analysis The expression analysis of the 17 AtESL : AtESL1.01 (At1g19450), AtESL1.02/ERDL6 (At1g75220), AtESL2.01/ZIF2 (At2g48020), AtESL2.02 (At3g5150), and AtESL2.03 (At5g18840), AtESL3.01 (At1g54730), AtESL3.02 (At4g4750), AtESL3.03 (At4g04760), AtESL3.04 (At3g20460), AtESL3.05/ESL3 (At1g08890), AtESL3.06/ESL2 (At1g08900), AtESL3.07/ESL1 (At1g08920) , AtESL3.08/ERD6 (At1g08930) , AtESL3.10 (At3g05400), AtESL3.11 (At3g05160), AtESL3.13/SFP1 (At5g27350), and...”
- First Come, First Served: Sui Generis Features of the First Intron
Zalabák, Plants (Basel, Switzerland) 2020 - “...131 ] PIF3 (At1g09530) upstream target of HID1 Arabidopsis [ 36 ] IR secondarystructure ZIF2 (At2g48020) upstream translation enhancement Arabidopsis [ 97 ] riboswitch PSY (At5g17230) upstream translation inhibition Arabidopsis [ 111 ] riboswitch CRK10 (At4g23180) downstream putative cytokinin-binding riboswitch Arabidopsis [ 112 ] uORF PIF3...”
- Quantitation of Vacuolar Sugar Transporter Abundance Changes Using QconCAT Synthtetic Peptides
Pertl-Obermeyer, Frontiers in plant science 2016 - “...across conditions. In other cases, such as for low abundant VMA21a (AT2G31710), VMA22 (AT1G20770), ERDL7 (AT2G48020), and ERDL8 (AT3G05150), the endogenous peptides (L) were less abundant than the spiked-in standard (H) leading to low L/H ratios across conditions. FIGURE 5 Selected examples of L/H ratio of...”
- “...Among the sugar transporters, significant and large increases in abundance were observed also for ERDL7 (AT2G48020) and TMT2 (AT4G35300). ERDL4 (AT1G19450) and ENT1 (AT1G70330) were the only sugar transporter for which no significant change in abundance was measured under salt stress. Under drought stress, for most...”
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Q41144 Sugar carrier protein C from Ricinus communis
28% identity, 82% coverage
- Omics Profiles of Non-transgenic Scion Grafted on Transgenic RdDM Rootstock.
Kodama, Food safety (Tokyo, Japan) 2022 - “...aminotransferase ACS10 Q9LQ10 5.75 GTE11_ARATH Transcription factor GTE11 Q93ZB7 3.74 STC_RICCO Sugar carrier protein C Q41144 3.15 XYLT_ARATH Beta-1,2-xylosyltransferase Q9LDH0 2.98 * TIF6B_ARATH Protein TIFY 6B Q9LVI4 2.87 EIX2_SOLLC Receptor-like protein EIX2 Q6JN46 2.56 XTH8_ARATH Probable xyloglucan endotransglucosylase/hydrolase protein 8 Q8L9A9 2.30 OPT5_ARATH Oligopeptide transporter 5...”
B7Z5A7 cDNA FLJ57557, highly similar to Solute carrier family 2, facilitated glucose transporter member 3 from Homo sapiens
32% identity, 84% coverage
LOC4352335 polyol transporter 5 from Oryza sativa Japonica Group
30% identity, 90% coverage
NCU08180 high-affinity glucose transporter from Neurospora crassa OR74A
32% identity, 69% coverage
BC1G_08389 hypothetical protein from Botrytis cinerea B05.10
32% identity, 81% coverage
- The BcLAE1 is involved in the regulation of ABA biosynthesis in Botrytis cinerea TB-31
Wei, Frontiers in microbiology 2022 - “...showed that the transcriptional levels of five putative sugar transporters and permeases increased significantly, namely BC1G_08389 (FC of 1.42), BC1G_11623 (FC of 3.55), BC1G_05673 (FC of 3.12), BC1G_12189 (FC of 3.01), and BC1G_05489 (FC of 1.79; Baruffini et al., 2006 ). Moreover, the transcriptional level of...”
- Comparative transcriptome analysis between an evolved abscisic acid-overproducing mutant Botrytis cinerea TBC-A and its ancestral strain Botrytis cinerea TBC-6
Ding, Scientific reports 2016 - “...especially during the stationary phase of the fermentation process. For example, the transcript abundance of Bc1G_08389, which encodes a HGT1, was more than 236.68-fold higher in the TBC-A-120h sample than that of the TBC-6-120h sample (RPKM values 357.38 vs. 1.51). Expression levels of genes encoding plant...”
Q3L7K6 Hexose transporter from Vitis vinifera
NP_001268207 hexose transporter from Vitis vinifera
30% identity, 82% coverage
- cDNA-AFLP analysis of plant and pathogen genes expressed in grapevine infected with Plasmopara viticola
Polesani, BMC genomics 2008 - “...1393 CG TT TC58567 103 - Apocytochrome f precursor (Q68RZ3) 4.92E-10 Transport 1614 TT CA Q3L7K6 185 + Hexose transporter 6.26E-08 * 680 CA GT TC52346 231 - Transporter-like protein (Q9LSH7) 3.88E-47 249 TA AC TC66367 107 - 14-3-3 protein (Q93XW1) 1.13E-16 1534 CC GG TC57372...”
- “...pathogens. In this context, the increased level of two genes with similarity to hexose transporters (Q3L7K6 and TC66367) is also worth noting. Carbohydrate accumulation may inhibit the Calvin cycle, which also limits photosynthesis [ 46 , 47 ]. Several genes encoding enzymes in the Calvin cycle...”
- Molecular analysis of post-harvest withering in grape by AFLP transcriptional profiling
Zamboni, Journal of experimental botany 2008 - “...CB006657 4.90E-08 Chloroplast outer membrane protein Q56WJ7 3.00E-10 Copper-transporting P-type ATPase TC64839 4.10E-11 Hexose transporter Q3L7K6 9.00E-12 Major facilitator superfamily MFS 1 TC61509 8.98E-27 Secretion protein HlyD TC60298 9.43E-39 Secretory carrier-associated membrane protein 1 TC52744 5.01E-05 Sucrose transporter-like protein TC51830 3.18E-22 Metabolic process Dopamine -mono-oxygenase N-terminal...”
- “...et al. , 2007 ). Carbohydrate transport and metabolism Our AFLP-TP experiment showed that VvHT5 (Q3L7K6), which encodes a hexose transporter (HT) located in the plasma membrane ( Hayes et al. , 2007 ), is up-regulated late in the withering process ( Table 3 ). This...”
- Involvement of abscisic acid in the coordinated regulation of a stress-inducible hexose transporter (VvHT5) and a cell wall invertase in grapevine in response to biotrophic fungal infection.
Hayes, Plant physiology 2010 - GeneRIF: central role for abscisic acid in the regulation of VvcwINV and VvHT5 expression during the transition from source to sink in response to infection by biotrophic pathogens
TC 2.A.1.1.98 / Q9FRL3 Sugar transporter ERD6-like 6 from Arabidopsis thaliana (see 3 papers)
AT1G75220 integral membrane protein, putative from Arabidopsis thaliana
33% identity, 87% coverage
- substrates: Sugars
- Mutations in SLC2A2 gene reveal hGLUT2 function in pancreatic β cell development
Michau, The Journal of biological chemistry 2013 - “...P32465 for yeast (Saccharomyces cerevisiae) HXT1; and Q9FRL3 for plant (Arabidopsis thaliana) sugar transporter protein STP1. Molecular Biology--Human SLC2A2...”
- Improving power of genome-wide association studies via transforming ordinal phenotypes into continuous phenotypes
Yang, Frontiers in plant science 2023 - “...2,3* sequence-specific DNA binding transcription factor activity AT2G18350 Glyma16g25310 # 29252235 pLARmEB 2,3* transmembrane transport AT1G75220 Glyma16g25320 # 29252235 pLARmEB 2,3* transmembrane transport AT1G75220 Glyma19g39270 46014852 FASTmrMLM 1* , pKWmEB 1* , pLARmEB 1* response to oxidative stress AT4G11290 Glyma19g39320 46014852 FASTmrMLM 1* , pKWmEB 1*...”
- Vacuolar Sugar Transporter TMT2 Plays Crucial Roles in Germination and Seedling Development in Arabidopsis
Cao, International journal of molecular sciences 2023 - “...(AT3G51490) , SAUR22 (AT5G18050) , SAUR23 (AT5G18060) , SAUR26 (AT3G03850) , SWEET2 (AT3G14770) , ERDL6 (AT1G75220) , DAO2 (AT1G14120) , PIN6 (AT1G77110) , CYP79B3 (AT2G22330) , TOR (AT1G50030) , KIN11 (AT3G29160) , E2F1 (AT5G22220) , ACTIN2 (AT3G18780) , ACTIN8 (AT1G49240) . Acknowledgments We are grateful to...”
- Responsiveness of Early Response to Dehydration Six-Like Transporter Genes to Water Deficit in Arabidopsis thaliana Leaves
Slawinski, Frontiers in plant science 2021 - “...stable during this process (Quirino et al., 2001 ). AtESL1.02/ERDL6 (early responsive to dehydration-like six At1g75220 ) is a vacuolar H + /glucose symporter involved in the export of glucose from the vacuole to cytosol (Klemens et al., 2014 ). This expression is regulated by the...”
- “...USA). Quantitative PCR Analysis The expression analysis of the 17 AtESL : AtESL1.01 (At1g19450), AtESL1.02/ERDL6 (At1g75220), AtESL2.01/ZIF2 (At2g48020), AtESL2.02 (At3g5150), and AtESL2.03 (At5g18840), AtESL3.01 (At1g54730), AtESL3.02 (At4g4750), AtESL3.03 (At4g04760), AtESL3.04 (At3g20460), AtESL3.05/ESL3 (At1g08890), AtESL3.06/ESL2 (At1g08900), AtESL3.07/ESL1 (At1g08920) , AtESL3.08/ERD6 (At1g08930) , AtESL3.10 (At3g05400), AtESL3.11 (At3g05160), AtESL3.13/SFP1...”
- Early Response to Dehydration Six-Like Transporter Family: Early Origin in Streptophytes and Evolution in Land Plants
Slawinski, Frontiers in plant science 2021 - “...into the vacuole (Remy et al., 2014 ). AtERDL6 (Early Responsive to Dehydration-Like six - At1g75220) is a tonoplastic H +g /glucose symporter involved in the export of glucose from the vacuole under the conditions that require the mobilization of vacuolar carbohydrate reserves. The expression of...”
- “...group Gene ID AtERD6-Llke x New names ESL1 B1a At1g19450 AtERD6-Like 4 ESL1.01 ESL1 B1b At1g75220 AtERD6-Like 6 ESL1.02/ERDL6 ESL2a B2 At2g48020 AtERD6-Like 7 ESL2.01/ZIF2 ESL2a B3 At3g05150 AtERD6-Like 8 ESL2.02 ESL2b B4 At5g18340 AtERD6-Like 16 ESL2.03 ESL3a B5 At1g54730 AtERD6-Like 5 ESL3.01 ESL3b B6a At4g04750...”
- Shotgun proteomics of peach fruit reveals major metabolic pathways associated to ripening
Nilo-Poyanco, BMC genomics 2021 - “...GLUCOSE-1-PHOSPHATE ADENYLYLTRANSFERASE LARGE SUBUNIT 2, CHLOROPLASTIC AT1G27680 Prupe.1G378500 0.998 2 Up_O1 SUGAR TRANSPORTER ERD6-LIKE 4-RELATED AT1G75220 Carbohydrates/Energy Metabolism Prupe.4G124500 0.998 2 Qualit_O1 Isocitrate dehydrogenase [NADP] AT1G54340 Prupe.3G288200 0.15 0 Up_O1 ISOCITRATE DEHYDROGENASE [NADP], CHLOROPLASTIC/MITOCHONDRIAL AT5G14590 Carbohydrates Metabolism/Redox Metabolism Prupe.2G091600 0.5 1 Up_O1 Malate dehydrogenase (NADP(+)) /...”
- Large-Scale Phosphoproteomic Study of Arabidopsis Membrane Proteins Reveals Early Signaling Events in Response to Cold
Kamal, International journal of molecular sciences 2020 - “...E,A * AT4G35300 TMT2 tonoplast monosaccharide transporter2 V,PM Solute transport HGS[+80]TMSR S 287 D * AT1G75220 ERDL6 Major facilitator superfamily protein V,PM Solute transport RPFIHTGS[+80]WYR S 23 D * AT2G18960 AHA1 H[+]-ATPase 1 PM Solute transport T[+80]LHGLQPKEDVNIFPEKGSYR T 881 D * AT2G18960 AHA1 H[+]-ATPase 1 PM...”
- A Genomic and Transcriptomic Overview of MATE, ABC, and MFS Transporters in Citrus sinensis Interaction with Xanthomonas citri subsp. citri
Julião, Plants (Basel, Switzerland) 2020 - “...ABC G Pistacia vera ABC G32 At2g26910 Cs3g24900 XP_006473508.3 STP Pyrus x bretschneideri ERD6-like 6 At1g75220 Limit a sugar source of Xanthomonas citri subsp. citri Cs1g24180 KDO79562.1 STP Durio zibethinus ERD6-like 6 At1g69650 Cs5g32060 XP_006479807.1 STP Pistacia vera ERD6-like 7 At2g45820...”
- Greenbug (Schizaphis graminum) herbivory significantly impacts protein and phosphorylation abundance in switchgrass (Panicum virgatum)
Zogli, Scientific reports 2020 - “...S EEEKKAEEALEAAAGDEAAVIDGAGSFK DEGs-up DPs-up Pavir.3KG261700 AT4G15530 Pyruvate orthophosphate dikinase 1 S DFEGIFR DEG-down DPs-down Pavir.3KG310400 AT1G75220 Major facilitator superfamily protein AGGAGYE S GSDHDGALQKPLLPNSGSWYR DEG-down DPs-down Pavir.3KG402302 AT1G15140 FAD/NAD(P)-binding oxidoreductase VVQLTQQFQQ S FLEQNLGEK DEG-down DPs-up Pavir.3NG065800 AT1G75240 Homeobox protein 33 VHLVGDPEHLGQLGGGMPLPEPGGPGR S P S PSR S PPPQQLR...”
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NCU04537 monosaccharide transporter from Neurospora crassa OR74A
30% identity, 81% coverage
- Correlating sugar transporter expression and activities to identify transporters for an orphan sugar substrate
Tamayo, Applied microbiology and biotechnology 2024 - “...crassa . For d -mannose, putative monosaccharide transporters from cluster 1 (like XYT-1, FRT-1, HGT-2, NCU04537, HGT-1, QaY, NCU06358, GLT-1, NCU06384, and NCU06138) could be potential candidates, but likely also only by contributing with unspecific side activities. Lactose uptake assays of transporter candidates Following the previous...”
- The regulatory and transcriptional landscape associated with carbon utilization in a filamentous fungus
Wu, Proceedings of the National Academy of Sciences of the United States of America 2020 - “...( 25 ). Of the predicted sugar transporters in this clade, five unannotated MFS transporters (NCU04537, NCU05350, NCU05585, NCU06384, and NCU07607) had increased expression on unique sugars and complex carbon sources, suggesting potential involvement in catabolism of those carbon sources ( SI Appendix , Fig. S1...”
- “...high-affinity glucose transporter, hgt-1 NCU10021 ( 35 ) and additional uncharacterized transporters (NCU00809, NCU06522, NCU09287, NCU04537, NCU01494, NCU06384, and NCU05897). An uncharacterized sugar transporter bound by CRE-1, sut-28 (NCU05897; annotated as a fucose permease; SI Appendix , Fig. S1 ), is a predicted ortholog of the...”
- Molecular Mechanisms of Chitosan Interactions with Fungi and Plants
Lopez-Moya, International journal of molecular sciences 2019 - “...deletion strain mutants confirms Lipase Class III, Monosaccharide transporter and Glutathione transferase encoding genes (NCU03639; NCU04537; NCU10521, respectively) as main chitosan targets in N. crassa [ 36 ]. They might play a role in membrane repair, assimilation of catabolites and buffering ROS surplus derived from chitosan...”
- Control of Development, Secondary Metabolism and Light-Dependent Carotenoid Biosynthesis by the Velvet Complex of Neurospora crassa
Bayram, Genetics 2019 - “...on 22 May 2021 Log2Fold change NCU10101 (llmG) NCU04537 NCU10761 (llmA) NCU03016 NCU00292 NCU00943 NCU08648 Table 2 Top 10 upregulated genes under standard...”
- A fungal transcription factor essential for starch degradation affects integration of carbon and nitrogen metabolism
Xiong, PLoS genetics 2017 - “...1e-20 identified 14 genes likely encoding transporters. Four of them, hgt-1 (NCU10021), NCU05627, NCU04963, and NCU04537 are annotated as sugar transporter genes ( Fig 2C ). hgt-1 shows high affinity glucose transport activity [ 19 ], while NCU05627 ( xyt-1 ) has xylose transporting activity [...”
- “...starch-active LPMO (NCU08746), gh13-6 and 19 transporter genes including hgt-1 , xyt-1 , NCU04963, and NCU04537 ( Fig 3C ). Seventeen TF genes in the starch regulon were also down regulated in the col-26 mutant, including tah-1 , tah-3 , vad-2 , ada-5 , and kal-1...”
- Regulated Forms of Cell Death in Fungi
Gonçalves, Frontiers in microbiology 2017 - “...Kontoyiannis, 2013a , b Chitosan N. crassa, Fusarium eumartii Nc : NCU03639 (class 3 lipase), NCU04537 (monosaccharide trans-porter), NCU10521 (gluta-thione S-transferase-4) Yes NA NA Palma-Guerrero et al., 2009 ; Terrile et al., 2014 ; Lopez-Moya et al., 2016 PLANT-DERIVED COMPOUNDS Camalexin Botrytis cinerea Bc : BcBir1...”
- Neurospora crassa transcriptomics reveals oxidative stress and plasma membrane homeostasis biology genes as key targets in response to chitosan
Lopez-Moya, Molecular bioSystems 2016 - “...NCU03639 encoding a class 3 lipase, involved in plasma membrane repair by lipid replacement and NCU04537 a MFS monosaccharide transporter related with assimilation of simple sugars, as main gene targets of chitosan. NCU10521, a glutathione S-transferase-4 involved in the generation of reducing power for scavenging intracellular...”
- “...stress (NCU05134 and NCU08907) and a monosaccharide transporter perhaps involved in chitosan assimilation or detoxification (NCU04537, fold-induction 9.27 after 16h growing with chitosan). Besides, other genes related with sugars assimilation were also induces in presence of chitosan such as NCU01633 ( hxt13 ; Table S2 )....”
- Direct target network of the Neurospora crassa plant cell wall deconstruction regulators CLR-1, CLR-2, and XLR-1
Craig, mBio 2015 - “...in xylobiose or xylose utilization and a xylose/glucose transporter. In addition, other uncharacterized sugar transporters (NCU04537 and NCU05350) and two hypothetical proteins (NCU06490 and NCU07510) were in this gene set ( Table3 ). TABLE3 Genes upregulated and differentially expressed in the wild-type strains versus a xlr-1...”
- “...a gh43-2 Xylosidase/arabinosidase NCU02343 gh51-1 Alpha- l -arabinofuranosidase NCU03322 GDSL family lipase NCU04401 Fructose-bisphosphate aldolase NCU04537 Monosaccharide transporter NCU04870 a ce1 - 1 Acetyl xylan esterase NCU05159 ce5 - 2 Acetyl xylan esterase NCU05350 Major facilitator transporter NCU06138 xy-31 Xylose transporter NCU06143 gh115-1 Putative glucuronidase NCU06490...”
- More
E2C2M2 Glucose transporter type 1 from Harpegnathos saltator
31% identity, 58% coverage
- A proteomic insight into the midgut proteome of Ornithodoros moubata females reveals novel information on blood digestion in argasid ticks.
Oleaga, Parasites & vectors 2017 - “...Another important protein in using glucose as an energy source is the glucose transporter 1 (E2C2M2), also identified in the transcriptome, which would be responsible for transporting blood glucose from the intestinal lumen to the inside of the enterocytes (Table 4 ). Table 4 Proteins involved...”
- “...(T) 0.13 Hydrolase activity Unfed EST_Acari A0A0B1PR88 Glucose-6-phosphate isomerase (T) 0.35 Isomerase activity Unfed mRNA_Om E2C2M2 Glucose transporter type 1 (T) 0.08 Carbohydrate transporter activity Fed mRNA_Om A0A087UZ87 ADP-dependent glucokinase (T) 0.05 Transferase activity Fed mRNA_Om Q7Q4V0 AGAP000862-PA (T) 0.24 Hydrolase activity Fed mRNA_Om B7PE53 Beta-hexosaminidase...”
Q6CFJ6 YALI0B06391p from Yarrowia lipolytica (strain CLIB 122 / E 150)
31% identity, 80% coverage
lpg1653 D-xylose-proton symporter from Legionella pneumophila subsp. pneumophila str. Philadelphia 1
32% identity, 91% coverage
- Mammalian Solute Carrier (SLC)-like transporters of Legionella pneumophila
Best, Scientific reports 2018 - “...human SLC2 and SLC5 family, we identified two putative SLC-like glucose transporters, lpg0421 (33%/50%) and lpg1653 (30%/48%) (Table 1 ). Structural modeling of these proteins was done using the Iterative Threading Assembly Refinement (I-TASSER) server, which is a bioinformatics algorithm for predicting three-dimensional structure based on...”
- “...substrates Representative SLC, TM-score LstA (Lpg0421) 33% 50% Glucose and other monosaccharides SLC2a1 (0.903) LstB (Lpg1653) 30% 48% Glucose and other monosaccharides SLC2a1 (0.922) LstC (Lpg0026) 37% 56% Cationic amino acids (arginine, lysine, ornithine) SLC7a1 (0.953) LstD (Lpg0049) 25% 44% Cationic amino acids (arginine, lysine, ornithine)...”
- Metabolism of myo-Inositol by Legionella pneumophila Promotes Infection of Amoebae and Macrophages
Manske, Applied and environmental microbiology 2016 - “...The L. pneumophila genome harbors the cluster lpg1653 to lpg1649 putatively involved in the metabolism of the abundant carbohydrate myo-inositol (here...”
- “...L. pneumophila, we constructed defined mutant strains lacking lpg1653 or lpg1652, which are predicted to encode the inositol transporter IolT or the...”
- bdhA-patD operon as a virulence determinant, revealed by a novel large-scale approach for identification of Legionella pneumophila mutants defective for amoeba infection
Aurass, Applied and environmental microbiology 2009 - “...lpg1469 lpg1507 lpg1596 lpg1610 lpg1615 lpg1634 lpg1638 lpg1653 lpg1665 lpg1702 lpg1762 lpg1805 lpg1843 lpg1925 lpg1974 lpg2011 lpg2031 lpg2032 lpg2132 lpg2257...”
ATEG_02489 uncharacterized protein from Aspergillus terreus NIH2624
31% identity, 81% coverage
- Transcriptome Profiling-Based Analysis of Carbohydrate-Active Enzymes in Aspergillus terreus Involved in Plant Biomass Degradation
Corrêa, Frontiers in bioengineering and biotechnology 2020 - “...the 48 h incubation period, namely ATEG_07791, ATEG_03475, ATEG_07105, ATEG_04988, ATEG_01556, ATEG_07124, ATEG_08653, ATEG_07144, ATEG_03527, ATEG_02489, ATEG_07114, ATEG_04070, ATEG_07053, ATEG_04137, ATEG_03190, and ATEG_05008. RT-qPCR Validation of in silico RNA-Seq Transcriptome Data Expression profiles for selected A. terreus CAZyme-encoding and other genes significantly up-regulated on SB and...”
PDIP_03090 MFS monosaccharide transporter, putative from Penicillium digitatum
32% identity, 82% coverage
LOC18046355 sugar transporter ERD6-like 7 from Citrus x clementina
33% identity, 92% coverage
H2QNR0 Solute carrier family 2, facilitated glucose transporter member 2 from Pan troglodytes
32% identity, 77% coverage
B3KVN0 Solute carrier family 2, facilitated glucose transporter member 1 from Homo sapiens
32% identity, 83% coverage
CNAG_07641 monosaccharide transporter from Cryptococcus neoformans var. grubii H99
30% identity, 72% coverage
- Galectin-3 impacts Cryptococcus neoformans infection through direct antifungal effects
Almeida, Nature communications 2017 - “...partial XM_012192132.1 2.80 0.0000 8.7 61.1 CNAG_03876 Ras family protein XM_012194860.1 2.74 0.0000 1.3 9.1 CNAG_07641 Monosaccharide transporter XM_012194944.1 2.73 0.0000 106.2 709.0 CNAG_05685 Neutral amino acid transporter XM_012194030.1 2.72 0.0000 5.6 37.0 CNAG_01252 Thiosulfate/3-mercaptopyruvate sulfurtransferase XM_012191185.1 2.72 0.0000 1089.1 7234.7 CNAG_00162 Alternative oxidase, mitochondrial XM_012192590.1...”
STP2 sugar transport protein 2 from Arabidopsis thaliana (see paper)
31% identity, 83% coverage
LOC110816261 sugar transport protein 14 from Carica papaya
30% identity, 82% coverage
NCU02582, XP_965713 RCO3 from Neurospora crassa OR74A
32% identity, 75% coverage
- Revisiting 2-Deoxyglucose Resistance in Neurospora crassa: Insights into Transcriptional Regulation of Hexose Transporters, Sugar Metabolism and Possible Modulation by Mating Type
Pandey, 2023 - Deletion of the col-26 Transcription Factor Gene and a Point Mutation in the exo-1 F-Box Protein Gene Confer Sorbose Resistance in Neurospora crassa
Hirai, Journal of fungi (Basel, Switzerland) 2022 - “...A NCU07788 mat A ; col -26:: Hyg r 11031 FGSC a sor -4 a NCU02582 mat a ; sor -4:: Hyg r 17928 FGSC a sor -4(DS(r)) A NCU02582 mat A ; sor -4(DS(r)) 1741 FGSC a hxk -2 a NCU00575 mat a ; hxk...”
- Glucose sensing and light regulation: A mutation in the glucose sensor RCO-3 modifies photoadaptation in Neurospora crassa.
Olmedo, Fungal biology 2018 (PubMed)- GeneRIF: The mutation in rco-3 modifies the transcriptional response to light of several genes and leads to changes in photoadaptation without significantly changing the amount and regulation of WC-1.
- Transcriptional comparison of the filamentous fungus Neurospora crassa growing on three major monosaccharides D-glucose, D-xylose and L-arabinose
Li, Biotechnology for biofuels 2014 - “...sugar transporters: NCU00821 ( Xyp29 , D-xylose-specific transporter), NCU08114 ( cdt-2 , cellodextrin transport) and NCU02582 ( rco-3 , glucose transporter) [ 9 , 31 , 32 ], and 10 putative sugar transporters, which will be discussed later. In addition, 50 of 300 CAZy genes were...”
- “...High affinity glucose transporter 23.68 38.96 16.02 NCU01868 MFS maltose permease malp 0.41 2.42 0.54 NCU02582 Rco3 9.65 42.90 12.30 NCU04310 Sugar transporter 9.68 26.59 12.88 NCU05350 Sugar transporter 0.37 10.25 0.55 NCU05585 MFS quinate transporter 1.01 47.89 1.52 NCU06026 Quinate permease 5.99 37.83 13.25 NCU06358...”
- Deciphering transcriptional regulatory mechanisms associated with hemicellulose degradation in Neurospora crassa
Sun, Eukaryotic cell 2012 - “...transporter genes (NCU00988, NCU01132, NCU02188, NCU02238, NCU02582, NCU05853, NCU06138, NCU06305, NCU06358, NCU08114, and NCU09027). In addition, 6...”
TC 2.A.1.1.14 / P15686 Hexose:H+ symporter of 534 aas and 12 TMSs from Chlorella kessleri (see 2 papers)
31% identity, 81% coverage
SACE_6319 probable sugar-transport integral membrane protein SugI from Saccharopolyspora erythraea NRRL 2338
33% identity, 93% coverage
F2D5N7 Predicted protein from Hordeum vulgare subsp. vulgare
31% identity, 82% coverage
- Identification of the Genetic Basis of Response to De-Acclimation in Winter Barley
Wójcik-Jagła, International journal of molecular sciences 2021 - “...function protein probable LRR receptor-like protein kinase At1g51890 [ Aegilops tauschii subsp. tauschii ] HORVU5HR1G055850 F2D5N7 N/A Predicted protein sugar transport protein 14 [ Aegilops tauschii subsp. Tauschii ] HORVU5HR1G059090 F2DCK3 N/A Hexosyltransferase hydroxyproline O-galactosyltransferase GALT3-like [ Aegilops tauschii subsp. tauschii ] HORVU5HR1G061930 A0A287RGQ6 N/A Unknown...”
NP_001273166 solute carrier family 2, facilitated glucose transporter member 14 isoform d from Homo sapiens
31% identity, 80% coverage
- Adaptation to HIF1α Deletion in Hypoxic Cancer Cells by Upregulation of GLUT14 and Creatine Metabolism.
Valli, Molecular cancer research : MCR 2019 (PubMed)- GeneRIF: Under hypoxia and HIF1 blockade, cancer cells adapt their energy metabolism via upregulation of the GLUT14 glucose transporter and creatine metabolism providing new avenues for drug targeting.
- The SLC2A14 gene, encoding the novel glucose/dehydroascorbate transporter GLUT14, is associated with inflammatory bowel disease.
Amir, The American journal of clinical nutrition 2017 - GeneRIF: Three alleles in the SLC2A14 gene associated independently with inflammatory bowel disease.
- The SLC2A14 gene: genomic locus, tissue expression, splice variants, and subcellular localization of the protein.
Amir, Biochemistry and cell biology = Biochimie et biologie cellulaire 2016 (PubMed)- GeneRIF: report presents an expanded SLC2A14 gene locus and a more diverse tissue expression, concurring with the existing evidence for disease associations
- Both GLUT-1 and GLUT-14 are Independent Prognostic Factors in Gastric Adenocarcinoma.
Berlth, Annals of surgical oncology 2015 (PubMed)- GeneRIF: High expression of GLUT-14 was associated with Gastric Adenocarcinoma.
- Genetic association of SLC2A14 polymorphism with Alzheimer's disease in a Han Chinese population.
Wang, Journal of molecular neuroscience : MN 2012 (PubMed)- GeneRIF: SLC2A14 polymorphism has a possible role in changing the genetic susceptibility to late Alzheimer disease age of onset in a Han Chinese population.
Q8LBI9 Sugar transporter ERD6-like 16 from Arabidopsis thaliana
AT5G18840 sugar transporter, putative from Arabidopsis thaliana
31% identity, 92% coverage
- Identification of internal reference genes for gene expression normalization between the two sexes in dioecious white Campion
Zemp, PloS one 2014 - “...ACACCCTTTGCGTTATGTGGGAGGT 143 60.4 1.88 Q9FLG1 GARX01000000 (contig_1352.1) SL_EDL16 F: GGGGCCAATTTCACTTGATGCTGGA R: TAATCCGCCTCGGATACTGGTTGGT 118 59.5 1.85 Q8LBI9 GARX01000000 (contig_13862.1) SL_METL1 F: TCCGGTGGTTGGGTTCCTCCTAAAA R:GCCGCATGCCAGTGTCAACAAAA 116 59.5 1.77 Q94AI4 GARX01000000 (contig_15898.1) SL_REF3 F: CGCCAGGCAGAGGTGTTAAACCAGA R: TAGCAGCAGTTACGAGCCCCAACA 145 60.5 1.77 no hit GARX01000000 (contig_17318.1) SL_REF4 F: AAAGCGACGATCTTAGGGCGGTTTG R: TCCCCATGTTTGGAGAGGAACTGCT 153...”
- Responsiveness of Early Response to Dehydration Six-Like Transporter Genes to Water Deficit in Arabidopsis thaliana Leaves
Slawinski, Frontiers in plant science 2021 - “...of the 17 AtESL : AtESL1.01 (At1g19450), AtESL1.02/ERDL6 (At1g75220), AtESL2.01/ZIF2 (At2g48020), AtESL2.02 (At3g5150), and AtESL2.03 (At5g18840), AtESL3.01 (At1g54730), AtESL3.02 (At4g4750), AtESL3.03 (At4g04760), AtESL3.04 (At3g20460), AtESL3.05/ESL3 (At1g08890), AtESL3.06/ESL2 (At1g08900), AtESL3.07/ESL1 (At1g08920) , AtESL3.08/ERD6 (At1g08930) , AtESL3.10 (At3g05400), AtESL3.11 (At3g05160), AtESL3.13/SFP1 (At5g27350), and AtESL3.14/SFP2 (At5g27360) of other vacuolar...”
- AsHSP26.8a, a creeping bentgrass small heat shock protein integrates different signaling pathways to modulate plant abiotic stress response
Sun, BMC plant biology 2020 - “...Carbohydrate metabolism-related proteins AT3G09020 1.37 alpha 1,4-glycosyltransferase family protein AT5G26340 1.37 sugar transport protein 13 AT5G18840 2.66 sugar transporter ERD6-like 16 AT3G49790 1.18 Carbohydrate-binding protein Nitrogen metabolism-related proteins AT1G02920 1.26 glutathione S-transferase 7/11 AT2G02930 1.48 glutathione S-transferase F3 AT5G62480 2.05 glutathione S-transferase tau 9 AT5G02780 1.78...”
- A sweet orange mutant impaired in carotenoid biosynthesis and reduced ABA levels results in altered molecular responses along peel ripening
Romero, Scientific reports 2019 - “...TRANSPORTER 1) 1.90 2.86 0.39 aC08002F04SK_c AT2G26910 ABCG32 (ABCG TRANSPORTER 32) 1.54 1.69 0.27 aC31803D02EF_c AT5G18840 ESL16 (PUTATIVE SUGAR TRANSPORTER 16) 0.95 2.31 1.17 Lipid biosynthetic process (GO:0008610; Level 6) aC31301D12EF_c AT2G22240 IPS2 (INOSITOL-3-PHOSPHATE SYNTHASE2) 2.24 3.66 1.15 aC31810H11EF_c AT5G49555 PDS (PHYTOENE DEHYDROGENASE) 1.88 3.02 0.88...”
- Genome-Wide Transcriptome Analysis Reveals Conserved and Distinct Molecular Mechanisms of Al Resistance in Buckwheat (Fagopyrum esculentum Moench) Leaves
Chen, International journal of molecular sciences 2017 - “...1.860 comp68193_c0_seq1 1.851 comp31329_c0_seq1 1.403 AT5G61520 Major facilitator superfamily protein Carbohydrate comp27968_c0_seq1 1.499 comp29178_c0_seq1 1.403 AT5G18840 Major facilitator superfamily protein Carbohydrate comp7291_c0_seq1 1.167 comp23114_c0_seq1 1.510 comp98352_c0_seq1 1.678 AT1G51340 MATE efflux family protein Citrate comp11267_c0_seq1 2.039 comp96590_c0_seq1 1.764 comp88250_c0_seq1 1.705 comp81877_c0_seq1 1.967 AT3G21090 ABCG15 Cutin comp56152_c0_seq1 2.033...”
- Phylloxera (Daktulosphaira vitifoliae Fitch) alters the carbohydrate metabolism in root galls to allowing the compatible interaction with grapevine (Vitis ssp.) roots
Griesser, Plant science : an international journal of experimental plant biology 2015 - “...GSVIVT01011047001 ERD6-like transporter Vverd6-like7 (at2g48020) 0.56 0.0001 n.d. n.d. n.d. TC123985 GSVIVT01017836001 ERD6-like transporter Vverd6-like16 (at5g18840) 1.36 3.39E06 1.6 1.0 0.9 TC126484 GSVIVT01022022001 ERD6-like transporter Vverd6-like8 (at3g05150) 0.77 1.23E05 n.d. n.d. n.d. TC115303 GSVIVT01010741001 Inositol transporter VvINT1 (at2g43330) 0.65 0.0004 1.0 0.7 0.8 TC113429 GSVIVT01021530001 Inositol...”
- Cytological investigations of the Arabidopsis thaliana elo1 mutant give new insights into leaf lateral growth and Elongator function
Falcone, Annals of botany 2007 - “...synthase (At4g02280), sucrose transporter (At1g71890), sugar transporter (At5g18840) and actin (At3g60830). The primers were designed using the Beacon designer...”
- “...synthase (At4g02280), sucrose transporter (At1g71890) and sugar transporter (At5g18840), with a function in sucrose metabolism was analysed by qPCR in Ler and...”
- The monosaccharide transporter gene family in land plants is ancient and shows differential subfamily expression and expansion across lineages
Johnson, BMC evolutionary biology 2006 - “...representation in the database and best match homologs in early lineages, three ( AtSTP7 , At5g18840 , and AtINT2 ) have microarray expression profiles consistent with broad expression and two ( At3g51490 and AtPLT4 ) appear to have limited expression, including expression in pollen. The broadly...”
- Phosphoinositide 5-phosphate and phosphoinositide 4-phosphate trigger distinct specific responses of Arabidopsis genes: genome-wide expression analyses
Alvarez-Venegas, Plant signaling & behavior 2006 - “...249955_at -2.02 1.53 sugar transporter, putative AT5G18840 253667_at -1.79 1.59 peroxidase, putative two-component responsive regulator/ response regulator 5...”
Afu1g03530 MFS sugar transporter, putative from Aspergillus fumigatus Af293
30% identity, 77% coverage
- Transcriptome and secretome analysis of Aspergillus fumigatus in the presence of sugarcane bagasse
de, BMC genomics 2018 - “...Database (AspGD; http://www.aspgd.org ) [ 32 ]. Three orthologous genes encoding possible putative xylose transporters (Afu1g03530, Afu4g14610, and Afu6g14442) and five related to cellobiose transporters (Afu3g01670, Afu6g14500, Afu6g14560, Afu7g05100, and Afu8g04480) have been identified in N. crassa , A. oryzae, A. niger , and A. nidulans...”
- “...xylose with an increase in up to 25-fold. On the other hand, the expression of Afu1g03530 increased to 250-, 180-, 25-, 60-, 200-, and 5-fold after 3, 6, 12, 18, 24, and 48h, respectively (Fig. 4b ). These results lead us to speculate that both genes...”
XP_011511389 solute carrier family 2, facilitated glucose transporter member 2 isoform X1 from Homo sapiens
32% identity, 79% coverage
5eqgA / P11166 Human glut1 in complex with inhibitor (2~{s})-3-(4-fluorophenyl)-2-[2- (3-hydroxyphenyl)ethanoylamino]-~{n}-[(1~{s})-1- phenylethyl]propanamide (see paper)
32% identity, 90% coverage
- Ligand: (2~{s})-3-(4-fluorophenyl)-2-[2-(3-hydroxyphenyl)ethanoylamino]-~{n}-[(1~{s})-1-phenylethyl]propanamide (5eqgA)
CNBG_0457 MFS transporter SP family solute carrier family 2 (myo-inositol transporter) member 13 from Cryptococcus deuterogattii R265
33% identity, 78% coverage
SLC2A2 / P11168 solute carrier family 2, facilitated glucose transporter member 2 from Homo sapiens (see 3 papers)
GTR2_HUMAN / P11168 Solute carrier family 2, facilitated glucose transporter member 2; Glucose transporter type 2, liver; GLUT-2 from Homo sapiens (Human) (see 9 papers)
TC 2.A.1.1.29 / P11168 Glucosamine/glucose uniporter, Glut-2; it may also transport dehydroascorbate (Mardones et al., 2011; from Homo sapiens (Human) (see 7 papers)
NP_000331 solute carrier family 2, facilitated glucose transporter member 2 isoform 1 from Homo sapiens
32% identity, 77% coverage
- function: Facilitative hexose transporter that mediates the transport of glucose, fructose and galactose (PubMed:16186102, PubMed:23396969, PubMed:28083649, PubMed:8027028, PubMed:8457197). Likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell (PubMed:8027028). May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney (PubMed:3399500). Also able to mediate the transport of dehydroascorbate (PubMed:23396969).
catalytic activity: D-glucose(out) = D-glucose(in) (RHEA:60376)
catalytic activity: D-fructose(out) = D-fructose(in) (RHEA:60372)
catalytic activity: L-dehydroascorbate(out) = L-dehydroascorbate(in) (RHEA:60380)
catalytic activity: D-galactose(in) = D-galactose(out) (RHEA:34915) - substrates: Glucosamine, glucose
tcdb comment: Maulén et al., 2003), and cotransport water against an osmotic gradient (Naftalin, 2008). Mutations may give rise to the rare autosomal recessive Fanconi-Bickel syndrome (Batool et al. 2019) - (Re-)Viewing Role of Intracellular Glucose Beyond Extracellular Regulation of Glucose-Stimulated Insulin Secretion by Pancreatic Cells
Firdos,, ACS omega 2024 - “...musculus P14246 SLC2A2 solute carrier family 2, facilitated glucose transporter member 2 524 H. sapiens P11168 RPA1 replication protein A 70kDa DNA-binding subunit 623 M. musculus Q8VEE4 RPA1 replication protein A 70kDa DNA-binding subunit 616 H. sapiens P27694 XRCC6/XRCC5 Ku7080 heterodimer A chain 609 H. sapiens...”
- Understanding the molecular mechanisms of human diseases: the benefits of fission yeasts.
Acs-Szabo, Microbial cell (Graz, Austria) 2024 - Do mitochondria use efflux pumps to protect their ribosomes from antibiotics?
Islam, Microbiology (Reading, England) 2023 - “...6.7E^12 Q8WW24, 1.4E^14 [ 79, 112 ] HXT13, NCU01633 Q1K4S3 MFS Q8J2J7, 2.1E^85 P23586, 1.2E^52 P11168, 2.6E^48 [ 79 ] NCU04809 Q756M6 MFS T2AWG3, 0.0014 Q8GYF4, 1.4E^24 B3KT41, 0.0022 [ 79 ] NCU09551 Q7S2B0 MFS G1UAY0, 2.3E^6 Q56ZZ7, 2.3E^7 Q8NBP5, 8.4E^9 [ 78 ] NCU10021 Q7S0I5...”
- A Network Pharmacology Method Combined with Molecular Docking Verification to Explore the Therapeutic Mechanisms Underlying Simiao Pill Herbal Medicine against Hyperuricemia
Qian, BioMed research international 2023 - “...P05181 54 CYP11A1 P05108 15 PPARG P37231 55 INS P01308 16 ESR1 P03372 56 SLC2A2 P11168 17 SELE P16581 57 CXCL8 P10145 18 CAT P04040 58 CRP P02741 19 MYC P01106 59 GCG P01275 20 TGFB1 P01137 60 UCP2 P55851 21 GPT P24298 61 CYP2C8 P10632...”
- Halophila beccarii extract ameliorate glucose uptake in 3T3-L1 adipocyte cells and improves glucose homeostasis in streptozotocin-induced diabetic rats.
Mathakala, Heliyon 2022 - “...transporter type (GLUT) 4, sequence was retrieved from UniProt web site (http://www.uniprot.org/; UniProt Entry ID: P11168 and P14672) and subjected to BLASTp program to obtain their homologue structures from Protein Data Bank. After BLASTp, the obtained PDB IDs 5EQG, 4PYP and 4ZW9 were selected as templates...”
- Extracellular Vesicles from Human Adipose-Derived Mesenchymal Stem Cells: A Review of Common Cargos.
Alonso-Alonso, Stem cell reviews and reports 2022 - “...[ 52 , 65 ] Solute carrier family 2, facilitated glucose transporter member 2* GTR2_HUMAN P11168 SLC2A2 [ 52 ] Solute carrier family 2, facilitated glucose transporter member 3* GTR3_HUMAN P11169 SLC2A3 [ 65 ] Solute carrier family 2, facilitated glucose transporter member 5* GTR5_HUMAN P22732...”
- Structural comparison of GLUT1 to GLUT3 reveal transport regulation mechanism in sugar porter family.
Custódio, Life science alliance 2021 - “...members of the Sugar Porter family. Alignment between human GLUT1 (UniProt P11166 ), GLUT2 (UniProt P11168 ), GLUT3 (UniProt P11169 ), GLUT4 (UniProt P14672 ), rGLUT5 (UniProt P43427 ), bGLUT5 (UniProt P58353 ), atSTP10 (UniProt Q9LT15 ), XylE (UniProt P0AGF4 ), and GlcPse (UniProt A0A0H2VG78 )....”
- Insights into Substrate and Inhibitor Selectivity among Human GLUT Transporters through Comparative Modeling and Molecular Docking
Ferreira, ACS omega 2019 - “...from a nonautomated procedure. Sequences were obtained from the UniProt database 30 (GLUT1: P11166; GLUT2: P11168; GLUT3: P11169; GLUT4: P14672; GLUT5: P22732; GLUT6: Q9UGQ3; GLUT7: Q6PXP3; GLUT8: Q9NY64; GLUT9: Q9NRM0; GLUT10: O95528; GLUT11: Q9BYW1; GLUT12: Q8TD20; GLUT13 (MYCT): Q96QE2; GLUT14: Q8TDB8). Sequence alignment was manually checked...”
- More
- Transmissible Gastroenteritis Virus Infection Enhances SGLT1 and GLUT2 Expression to Increase Glucose Uptake
Dai, PloS one 2016 - “.... 1 88% SGLT1 NM-001012297 . 1 NP_001035915 . 1 88% GLUT2 AMN88560 . 1 NP_000331 . 1 87% Glucose uptake experiments 2-[ 3 H]deoxyglucose (2-DG) uptake experiments were carried out according to the method described by Henriksen et al ., but with modifications [ 14...”
For advice on how to use these tools together, see
Interactive tools for functional annotation of bacterial genomes.
The PaperBLAST database links 784,739 different protein sequences to 1,253,012 scientific articles. Searches against EuropePMC were last performed on November 25 2024.
PaperBLAST builds a database of protein sequences that are linked
to scientific articles. These links come from automated text searches
against the articles in EuropePMC
and from manually-curated information from GeneRIF, UniProtKB/Swiss-Prot,
BRENDA,
CAZy (as made available by dbCAN),
BioLiP,
CharProtDB,
MetaCyc,
EcoCyc,
TCDB,
REBASE,
the Fitness Browser,
and a subset of the European Nucleotide Archive with the /experiment tag.
Given this database and a protein sequence query,
PaperBLAST uses protein-protein BLAST
to find similar sequences with E < 0.001.
To build the database, we query EuropePMC with locus tags, with RefSeq protein
identifiers, and with UniProt
accessions. We obtain the locus tags from RefSeq or from MicrobesOnline. We use
queries of the form "locus_tag AND genus_name" to try to ensure that
the paper is actually discussing that gene. Because EuropePMC indexes
most recent biomedical papers, even if they are not open access, some
of the links may be to papers that you cannot read or that our
computers cannot read. We query each of these identifiers that
appears in the open access part of EuropePMC, as well as every locus
tag that appears in the 500 most-referenced genomes, so that a gene
may appear in the PaperBLAST results even though none of the papers
that mention it are open access. We also incorporate text-mined links
from EuropePMC that link open access articles to UniProt or RefSeq
identifiers. (This yields some additional links because EuropePMC
uses different heuristics for their text mining than we do.)
For every article that mentions a locus tag, a RefSeq protein
identifier, or a UniProt accession, we try to select one or two
snippets of text that refer to the protein. If we cannot get access to
the full text, we try to select a snippet from the abstract, but
unfortunately, unique identifiers such as locus tags are rarely
provided in abstracts.
PaperBLAST also incorporates manually-curated protein functions:
- Proteins from NCBI's RefSeq are included if a
GeneRIF
entry links the gene to an article in
PubMed®.
GeneRIF also provides a short summary of the article's claim about the
protein, which is shown instead of a snippet.
- Proteins from Swiss-Prot (the curated part of UniProt)
are included if the curators
identified experimental evidence for the protein's function (evidence
code ECO:0000269). For these proteins, the fields of the Swiss-Prot entry that
describe the protein's function are shown (with bold headings).
- Proteins from BRENDA,
a curated database of enzymes, are included if they are linked to a paper in PubMed
and their full sequence is known.
- Every protein from the non-redundant subset of
BioLiP,
a database
of ligand-binding sites and catalytic residues in protein structures, is included. Since BioLiP itself
does not include descriptions of the proteins, those are taken from the
Protein Data Bank.
Descriptions from PDB rely on the original submitter of the
structure and cannot be updated by others, so they may be less reliable.
(For SitesBLAST and Sites on a Tree, we use a larger subset of BioLiP so that every
ligand is represented among a group of structures with similar sequences, but for
PaperBLAST, we use the non-redundant set provided by BioLiP.)
- Every protein from EcoCyc, a curated
database of the proteins in Escherichia coli K-12, is included, regardless
of whether they are characterized or not.
- Proteins from the MetaCyc metabolic pathway database
are included if they are linked to a paper in PubMed and their full sequence is known.
- Proteins from the Transport Classification Database (TCDB)
are included if they have known substrate(s), have reference(s),
and are not described as uncharacterized or putative.
(Some of the references are not visible on the PaperBLAST web site.)
- Every protein from CharProtDB,
a database of experimentally characterized protein annotations, is included.
- Proteins from the CAZy database of carbohydrate-active enzymes
are included if they are associated with an Enzyme Classification number.
Even though CAZy does not provide links from individual protein sequences to papers,
these should all be experimentally-characterized proteins.
- Proteins from the REBASE database
of restriction enzymes are included if they have known specificity.
- Every protein with an evidence-based reannotation (based on mutant phenotypes)
in the Fitness Browser is included.
- Sequence-specific transcription factors (including sigma factors and DNA-binding response regulators)
with experimentally-determined DNA binding sites from the
PRODORIC database of gene regulation in prokaryotes.
- Putative transcription factors from RegPrecise
that have manually-curated predictions for their binding sites. These predictions are based on
conserved putative regulatory sites across genomes that contain similar transcription factors,
so PaperBLAST clusters the TFs at 70% identity and retains just one member of each cluster.
- Coding sequence (CDS) features from the
European Nucleotide Archive (ENA)
are included if the /experiment tag is set (implying that there is experimental evidence for the annotation),
the nucleotide entry links to paper(s) in PubMed,
and the nucleotide entry is from the STD data class
(implying that these are targeted annotated sequences, not from shotgun sequencing).
Also, to filter out genes whose transcription or translation was detected, but whose function
was not studied, nucleotide entries or papers with more than 25 such proteins are excluded.
Descriptions from ENA rely on the original submitter of the
sequence and cannot be updated by others, so they may be less reliable.
Except for GeneRIF and ENA,
the curated entries include a short curated
description of the protein's function.
For entries from BioLiP, the protein's function may not be known beyond binding to the ligand.
Many of these entries also link to articles in PubMed.
For more information see the
PaperBLAST paper (mSystems 2017)
or the code.
You can download PaperBLAST's database here.
Changes to PaperBLAST since the paper was written:
- November 2023: incorporated PRODORIC and RegPrecise. Many PRODORIC entries were not linked to a protein sequence (no UniProt identifier), so we added this information.
- February 2023: BioLiP changed their download format. PaperBLAST now includes their non-redundant subset. SitesBLAST and Sites on a Tree use a larger non-redundant subset that ensures that every ligand is represented within each cluster. This should ensure that every binding site is represented.
- June 2022: incorporated some coding sequences from ENA with the /experiment tag.
- March 2022: incorporated BioLiP.
- April 2020: incorporated TCDB.
- April 2019: EuropePMC now returns table entries in their search results. This has expanded PaperBLAST's database, but most of the new entries are of low relevance, and the resulting snippets are often just lists of locus tags with annotations.
- February 2018: the alignment page reports the conservation of the hit's functional sites (if available from from Swiss-Prot or UniProt)
- January 2018: incorporated BRENDA.
- December 2017: incorporated MetaCyc, CharProtDB, CAZy, REBASE, and the reannotations from the Fitness Browser.
- September 2017: EuropePMC no longer returns some table entries in their search results. This has shrunk PaperBLAST's database, but has also reduced the number of low-relevance hits.
Many of these changes are described in Interactive tools for functional annotation of bacterial genomes.
PaperBLAST cannot provide snippets for many of the papers that are
published in non-open-access journals. This limitation applies even if
the paper is marked as "free" on the publisher's web site and is
available in PubmedCentral or EuropePMC. If a journal that you publish
in is marked as "secret," please consider publishing elsewhere.
Many important articles are missing from PaperBLAST, either because
the article's full text is not in EuropePMC (as for many older
articles), or because the paper does not mention a protein identifier such as a locus tag, or because of PaperBLAST's heuristics. If you notice an
article that characterizes a protein's function but is missing from
PaperBLAST, please notify the curators at UniProt
or add an entry to GeneRIF.
Entries in either of these databases will eventually be incorporated
into PaperBLAST. Note that to add an entry to UniProt, you will need
to find the UniProt identifier for the protein. If the protein is not
already in UniProt, you can ask them to create an entry. To add an
entry to GeneRIF, you will need an NCBI Gene identifier, but
unfortunately many prokaryotic proteins in RefSeq do not have
corresponding Gene identifers.
References
PaperBLAST: Text-mining papers for information about homologs.
M. N. Price and A. P. Arkin (2017). mSystems, 10.1128/mSystems.00039-17.
Europe PMC in 2017.
M. Levchenko et al (2017). Nucleic Acids Research, 10.1093/nar/gkx1005.
Gene indexing: characterization and analysis of NLM's GeneRIFs.
J. A. Mitchell et al (2003). AMIA Annu Symp Proc 2003:460-464.
UniProt: the universal protein knowledgebase.
The UniProt Consortium (2016). Nucleic Acids Research, 10.1093/nar/gkw1099.
BRENDA in 2017: new perspectives and new tools in BRENDA.
S. Placzek et al (2017). Nucleic Acids Research, 10.1093/nar/gkw952.
The EcoCyc database: reflecting new knowledge about Escherichia coli K-12.
I. M. Keeseler et al (2016). Nucleic Acids Research, 10.1093/nar/gkw1003.
The MetaCyc database of metabolic pathways and enzymes.
R. Caspi et al (2018). Nucleic Acids Research, 10.1093/nar/gkx935.
CharProtDB: a database of experimentally characterized protein annotations.
R. Madupu et al (2012). Nucleic Acids Research, 10.1093/nar/gkr1133.
The carbohydrate-active enzymes database (CAZy) in 2013.
V. Lombard et al (2014). Nucleic Acids Research, 10.1093/nar/gkt1178.
The Transporter Classification Database (TCDB): recent advances
M. H. Saier, Jr. et al (2016). Nucleic Acids Research, 10.1093/nar/gkv1103.
REBASE - a database for DNA restriction and modification: enzymes, genes and genomes.
R. J. Roberts et al (2015). Nucleic Acids Research, 10.1093/nar/gku1046.
Deep annotation of protein function across diverse bacteria from mutant phenotypes.
M. N. Price et al (2016). bioRxiv, 10.1101/072470.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory