PaperBLAST
PaperBLAST Hits for reanno::Smeli:SM_b20326 ABC transporter for D-trehalose/D-maltose/sucrose, permease component 1 (ThuF) (Sinorhizobium meliloti 1021) (328 a.a., MTDLSLADRP...)
Show query sequence
>reanno::Smeli:SM_b20326 ABC transporter for D-trehalose/D-maltose/sucrose, permease component 1 (ThuF) (Sinorhizobium meliloti 1021)
MTDLSLADRPAALAHGGRIGSDLQAQRVRSAWLFLAPTFLVLALVAGWPLIRTIYFSFTN
ASLTNLSGAEFVGFANYLSWITLKSGRTIYRGLLADPAWWNAVWNTLKFTVLSVSIETAL
GLIVALVLNAQFPGRGLVRAAILIPWAIPTIVSAKMWAWMLNDQFGILNDMLIGLGLIGE
KIAWTASPDTAMIAELIVDVWKTTPFMALLILAGLQMVPGDIYEAAKIDGVHPVRVFWRV
TLPLIRPALMVAVIFRMLDALRIFDLIYVLTPNNAQTKTMSVMARENLFDFDKFAYGAAA
STMLFLIIATITILYMWLGRLNLSGGER
Running BLASTp...
Found 250 similar proteins in the literature:
SM_b20326 ABC transporter for D-trehalose/D-maltose/sucrose, permease component 1 (ThuF) from Sinorhizobium meliloti 1021
TC 3.A.1.1.17 / Q9R9Q6 ThuF aka RB0312 aka SMB20326, component of Trehalose/maltose/sucrose porter (trehalose inducible) from Rhizobium meliloti (Sinorhizobium meliloti) (see 3 papers)
100% identity, 100% coverage
- mutant phenotype: Specific phenotype on trehalose, but also reported to transport maltose and sucrose (PMID:12003938; also PMC1635973)
- substrates: Maltose, Sucrose, Trehalose
TC 3.A.1.1.19 / Q8L125 PalF, component of Platinose (isomaltulose) (6-O-α-D-glucopyranosyl-D-fructofuranose) porter from Agrobacterium tumefaciens (see 3 papers)
80% identity, 100% coverage
BRA0305 sugar ABC transporter, permease protein from Brucella suis 1330
BCAN_B0306 binding-protein-dependent transport systems inner membrane component from Brucella canis ATCC 23365
83% identity, 95% coverage
- ATP-Binding Cassette Systems of Brucella
Jenner, Comparative and functional genomics 2009 - “...OSP Maltose import IM BMEII0942 BruAb20875 BRA0306 BOV_A0281 BCAN_B0307 OSP Maltose import IM BMEII0943 BruAb20876 BRA0305 BOV_A0280 BCAN_B0306 OSP Maltose import BP BMEII0944 BOV_A0279 OSP Maltose import BP BMEII0945 BruAb20877 BRA0304 BCAN_B0305 82 OTCN Glycine betaine/L-proline import ABC BMEI0439, proV BruAb11568 BR1581 BOV_1526 BCAN_A1616 OTCN Glycine...”
- ATP-Binding Cassette Systems of Brucella
Jenner, Comparative and functional genomics 2009 - “...import IM BMEII0942 BruAb20875 BRA0306 BOV_A0281 BCAN_B0307 OSP Maltose import IM BMEII0943 BruAb20876 BRA0305 BOV_A0280 BCAN_B0306 OSP Maltose import BP BMEII0944 BOV_A0279 OSP Maltose import BP BMEII0945 BruAb20877 BRA0304 BCAN_B0305 82 OTCN Glycine betaine/L-proline import ABC BMEI0439, proV BruAb11568 BR1581 BOV_1526 BCAN_A1616 OTCN Glycine betaine/L-proline import...”
BOV_A0280 sugar ABC transporter, permease protein from Brucella ovis ATCC 25840
83% identity, 95% coverage
- ATP-Binding Cassette Systems of Brucella
Jenner, Comparative and functional genomics 2009 - “...Maltose import IM BMEII0942 BruAb20875 BRA0306 BOV_A0281 BCAN_B0307 OSP Maltose import IM BMEII0943 BruAb20876 BRA0305 BOV_A0280 BCAN_B0306 OSP Maltose import BP BMEII0944 BOV_A0279 OSP Maltose import BP BMEII0945 BruAb20877 BRA0304 BCAN_B0305 82 OTCN Glycine betaine/L-proline import ABC BMEI0439, proV BruAb11568 BR1581 BOV_1526 BCAN_A1616 OTCN Glycine betaine/L-proline...”
RC1_3730 maltose transport system permease protein malF, putative from Rhodospirillum centenum SW
57% identity, 95% coverage
Pf1N1B4_5113 sucrose ABC transporter, permease component 1 from Pseudomonas fluorescens FW300-N1B4
61% identity, 91% coverage
- mutant phenotype: Specific phenotype on sucrose
BMEII0943 MALTOSE TRANSPORT SYSTEM PERMEASE PROTEIN MALF from Brucella melitensis 16M
86% identity, 52% coverage
- ATP-Binding Cassette Systems of Brucella
Jenner, Comparative and functional genomics 2009 - “...BOV_A0282 BCAN_B0308 OSP Maltose import IM BMEII0942 BruAb20875 BRA0306 BOV_A0281 BCAN_B0307 OSP Maltose import IM BMEII0943 BruAb20876 BRA0305 BOV_A0280 BCAN_B0306 OSP Maltose import BP BMEII0944 BOV_A0279 OSP Maltose import BP BMEII0945 BruAb20877 BRA0304 BCAN_B0305 82 OTCN Glycine betaine/L-proline import ABC BMEI0439, proV BruAb11568 BR1581 BOV_1526 BCAN_A1616...”
TC 3.A.1.1.25 / Q72H67 Maltose transport system permease protein malF aka TT_C1628, component of The trehalose/maltose/sucrose/palatinose porter (TTC1627-9) plus MalK1 (ABC protein, shared with 3.A.1.1.24) (Silva et al. 2005; Chevance et al., 2006). The receptor (TTC1627) binds disaccharide alpha-glycosides, namely trehalose (alpha-1,1), sucrose (alpha-1,2), maltose (alpha-1,4), palatinose (alpha-1,6) and glucose from Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) (see paper)
TTC1628 No description from Thermus thermophilus HB27
51% identity, 90% coverage
TC 3.A.1.1.41 / G4FGN7 ABC-type transporter, integral membrane subunit, component of Trehalose porter. Also binds sucrose (Boucher and Noll, 2011). Induced by glucose and trehalose. Directly regulated by trehalose-responsive regulator TreR from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
46% identity, 90% coverage
TC 3.A.1.1.12 / Q9AI67 PalF, component of Palatinose (isomaltulose; 6-O-α-D-glucopyranosyl-D-fructose) uptake porter from Erwinia rhapontici (see paper)
46% identity, 95% coverage
cg0832 ABC transporter membrane protein from Corynebacterium glutamicum ATCC 13032
46% identity, 82% coverage
- Functional Genomics Uncovers Pleiotropic Role of Rhomboids in Corynebacterium glutamicum
Luenenschloss, Frontiers in microbiology 2022 - “...30C. Components of an ABC-type maltose uptake system (Cg2704, Cg2705) and ABC-type trehalose uptake system (Cg0832, Cg0834) were less abundant in the CF as well as MF at 30 and/or 40C. Since 4-alpha-D-((1- > 4)-alpha-D-glucano)trehalose trehalohydrolase (Cg2333) was present at much higher amounts in the MF...”
- Identification and characterization of a bacterial transport system for the uptake of pyruvate, propionate, and acetate in Corynebacterium glutamicum
Jolkver, Journal of bacteriology 2009 - “...and 98 bp upstream of the start codon of cg0832. However, the functionality and the significance of these binding sites and the involvement of GlxR in...”
- Functional genomics of pH homeostasis in Corynebacterium glutamicum revealed novel links between pH response, oxidative stress, iron homeostasis and methionine synthesis
Follmann, BMC genomics 2009 - “...synthase 2 0 -1.39 n.d. - 1.7 0.8 - - - - - - 36 cg0832 ABC-type transporter, permease components 5 -1.33 -0.40 - - - -0.4 - - - 1.0 1.1 37 cg0834 ABC-type transporter, periplasmic component 0 -2.46 -0.03 1.6 3.4 2.7 2.5 3.6...”
C289_1911 ABC transporter permease subunit from Anoxybacillus ayderensis
46% identity, 58% coverage
- A high molecular-mass Anoxybacillus sp. SK3-4 amylopullulanase: characterization and its relationship in carbohydrate utilization
Kahar, International journal of molecular sciences 2013 - “...(C289_0465, C289_0466, C289_0467, C289_0603, C289_0763, C289_0764, C289_0765, C289_0778, C289_0779, C289_0780, C289_1015, C289_1174, C289_1392, C289_1394, C289_1910, C289_1911, and C289_1912) were also found in the Blast2GO annotation. The draft genome was submitted to the National Center for Biotechnology Information (NCBI) Bioproject with accession no. PRJNA174378. 2.2. Analysis of...”
BMEII0944 MALTOSE TRANSPORT SYSTEM PERMEASE PROTEIN MALF from Brucella melitensis 16M
77% identity, 40% coverage
- ATP-Binding Cassette Systems of Brucella
Jenner, Comparative and functional genomics 2009 - “...BOV_A0281 BCAN_B0307 OSP Maltose import IM BMEII0943 BruAb20876 BRA0305 BOV_A0280 BCAN_B0306 OSP Maltose import BP BMEII0944 BOV_A0279 OSP Maltose import BP BMEII0945 BruAb20877 BRA0304 BCAN_B0305 82 OTCN Glycine betaine/L-proline import ABC BMEI0439, proV BruAb11568 BR1581 BOV_1526 BCAN_A1616 OTCN Glycine betaine/L-proline import IM BMEI0440, proW BruAb11567 BR1580...”
PF1740 trehalose/maltose transport inner membrane protein from Pyrococcus furiosus DSM 3638
39% identity, 92% coverage
MALF_THELN / O51924 Trehalose/maltose transport system permease protein MalF from Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C) (see 3 papers)
39% identity, 92% coverage
- function: Part of the ABC transporter complex MalEFGK involved in trehalose/maltose import. Responsible for the translocation of the substrate across the membrane.
subunit: The complex is composed of two ATP-binding proteins (MalK), two transmembrane proteins (MalG and MalF) and a solute-binding protein (MalE).
BF29_RS14615 carbohydrate ABC transporter permease from Heyndrickxia coagulans DSM 1 = ATCC 7050
43% identity, 57% coverage
- Time-resolved transcriptomic and proteomic profiling of <i>Heyndrickxia coagulans</i> during NaOH-buffered L-lactic acid production
Huang, Frontiers in microbiology 2023 - “...increases including glycoside-pentoside-hexuronide (GPH): cation symporter (BF29_RS06670), MFS transporter (BF29_RS16105), and sugar ABC transporter permease (BF29_RS14615). Moreover, we noted a substantial increase observed in the expression level of the AraC family transcription factor (BF29_RS14625). 3.3 Comparative proteomic analysis The numbers of DEPs observed at a 5h...”
- “...acquisition in H. coagulans DSM1-mediated L-LA production. ThuEFG constitutes a trehalose/maltose transport system; with ThuF (BF29_RS14615) and ThuG (BF29_RS14610) serve as permease proteins, and ThuE (BF29_RS14620) acts as the substrate-binding protein ( Jensen et al., 2002 ). Trehalose is widely recognized as a universal stress molecule...”
TC 3.A.1.1.7 / O51924 MalF, component of Maltose/trehalose porter from Thermococcus litoralis (see paper)
39% identity, 92% coverage
- substrates: Maltose, Trehalose
MSMEG_5060 ABC transporter, permease protein SugA from Mycobacterium smegmatis str. MC2 155
MSMEG_5060 carbohydrate ABC transporter permease from Mycolicibacterium smegmatis MC2 155
37% identity, 91% coverage
- Elucidating the role of c-di-AMP in Mycobacterium smegmatis: Phenotypic characterization and functional analysis
Chaudhary, Heliyon 2023 - “...ABC transporter, permease protein 1.35 0.040 9 MSMEG_4657 ABC transporter membrane protein 1.11 0.057 10 MSMEG_5060 ABC transporter, permease protein SugA 1.51 0.0361 11 MSMEG_0642 Hypothetical ABC transporter permease protein YliD 1.32 0.044 12 MSMEG_0549 ABC transporter, permease protein 1.35 0.040 13 MSMEG_6307 Glutamine-binding periplasmic protein/glutamine...”
- Structural basis of trehalose recycling by the ABC transporter LpqY-SugABC
Liu, Science advances 2020 - “...DNA and overexpressed in M. smegmatis mc 2 155 . MSMEG_5058 , MSMEG_5059 , and MSMEG_5060 were amplified by polymerase chain reaction (PCR) and inserted into a pM261 vector, with a C-terminal 6 His-tag attached to SugC. The recombinant plasmid was transformed into M. smegmatis mc...”
- “...mutated to glutamine. A coexpression vector was constructed by amplification of MSMEG_5058 (E164Q), MSMEG_5059 , MSMEG_5060 , and MSMEG_5061 from M. smegmatis strain mc 2 155 genomic DNA by PCR and insertion into a pM261 expression vector with a C-terminal 6 His-tag. LpqY-SugABC was expressed and...”
- A VapBC toxin-antitoxin module is a posttranscriptional regulator of metabolic flux in mycobacteria
McKenzie, Journal of bacteriology 2012 - “...MSMEG_4664 MSMEG_4665 MSMEG_4666 MSMEG_5057 MSMEG_5058 MSMEG_5059 MSMEG_5060 MSMEG_5061 MSMEG_5062 iolB iolD iolE sugK sugG sugF sugE Succinate MSMEG_5302...”
sugA / P9WG03 ABC-type trehalose transporter integral membrane protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
SUGA_MYCTU / P9WG03 Trehalose transport system permease protein SugA from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
TC 3.A.1.1.31 / O50452 PROBABLE SUGAR-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER SUGA, component of The trehalose-recycling ABC transporter, LpqY-SugA-SugB-SugC (essential for virulence) from Mycobacterium tuberculosis (see 2 papers)
NP_215752 sugar ABC transporter permease SugA from Mycobacterium tuberculosis H37Rv
Rv1236 PROBABLE SUGAR-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER SUGA from Mycobacterium tuberculosis H37Rv
Mb1268 PROBABLE SUGAR-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER SUGA from Mycobacterium bovis AF2122/97
35% identity, 98% coverage
- function: Part of the ABC transporter complex LpqY-SugA-SugB-SugC, which is highly specific for uptake of trehalose. Involved in the recycling of extracellular trehalose released from trehalose-containing molecules synthesized by M.tuberculosis. Trehalose uptake is essential for virulence. Probably responsible for the translocation of the substrate across the membrane.
subunit: The complex is composed of two ATP-binding proteins (SugC), two transmembrane proteins (Suga and SugB) and a solute-binding protein (LpqY). - substrates: Trehalose
- Trehalose-recycling ABC transporter LpqY-SugA-SugB-SugC is essential for virulence of Mycobacterium tuberculosis.
Kalscheuer, Proceedings of the National Academy of Sciences of the United States of America 2010 - GeneRIF: Data show that the LpqY-SugA-SugB-SugC ATP-binding cassette transporter is a recycling system mediating the retrograde transport of released trehalose.
- Genome-wide screen identifies host loci that modulate Mycobacterium tuberculosis fitness in immunodivergent mice
Meade, G3 (Bethesda, Md.) 2023 - “...37.760 3.34 24.764 128.756 2.82E02 hp042 Rv1913 Rv1913 7 39.822 3.63 30.689 145.321 2.96E03 hp043 Rv1236 sugA 7 40.289 3.13 24.822 140.297 5.28E03 hp044 Rv1528c papA4 7 40.289 4.97 40.226 46.357 2.11E02 hp045 Rv1542c glbN 7 40.289 3.71 3.078 145.321 5.77E02 hp046 Rv1992c ctpG 7 40.289...”
- Genomic analysis of Mycobacterium brumae sustains its nonpathogenic and immunogenic phenotype
Renau-Mínguez, Frontiers in microbiology 2022 - “...Two-Component System (TCS) 76.2 100 Rv1002c Rv1002c 1,118,428 1,119,939 Reverse Other virulence factors 72.4 100 Rv1236 sugA 1,378,927 1,379,850 Forward Protein ABC transporter 73.1 93.8 Rv1237 sugB 1,379,855 1,380,679 Forward Protein ABC transporter 81.1 98.9 Rv1238 sugC 1,380,684 1,381,865 Forward Protein ABC transporter 78.7 100 Rv1293...”
- Shotgun proteomic profiling of dormant, 'non-culturable' Mycobacterium tuberculosis
Nikitushkin, PloS one 2022 - “...consistency in behaviour of proteins of the ABC trehalose transporter complex LpqYSugASugBSugC ( Rv1235 , Rv1236 , Rv1237 , Rv1238 ): out of four annotated in the Mtb genome only Rv1235 and Rv1238 were detected in the current study, albeit with a different sign of FC...”
- Heat-killed Mycolicibacterium aurum Aogashima: An environmental nonpathogenic actinobacteria under development as a safe novel food ingredient
Nouioui, Food science & nutrition 2021 - “...orf01262 Rv3824c 51.0 <95 2E170 lpq Y orf03429 Rv1235 28.3 <60% 2E53 sug A orf03428 Rv1236 53.0 <60% 3E91 sug B orf03427 Rv1237 57.1 <60% 3E109 sug C orf03426 Rv1238 53.9 <60% 8E142 Copper uptake Copper exporter ctp V orf03576 Rv0969 54.3 <60% 0 fad D33...”
- ATP-binding cassette (ABC) import systems of Mycobacterium tuberculosis: target for drug and vaccine development
Soni, Emerging microbes & infections 2020 - “...of sn-glycerol-3-phosphate and maltose [ 39 ] Trehalose importer (LpqY-SugABC/Rv1235-Rv1238) SBP: LpqY (Rv1235) TMD: SugA (Rv1236) and SugB (Rv1237) NBD: SugC (Rv1238) (two copies) LpqY-SugABC mutant shows reduced virulence in mice [ 43 ] Uptake and recycle disaccharide trehalose [ 43 ] Involved in biofilm formation...”
- A systematic assessment of mature MBP in membrane protein production: overexpression, membrane targeting and purification
Hu, Protein expression and purification 2011 - “...Rv3277 4 30.0 o o Rv3101c 4 32.8 + + Rv1304 5 27.5 o o Rv1236 5 33.0 o + Rv1337 6 25.7 o o Rv1457c 6 27.3 o o Rv1237 6 29.1 o o Rv2398c 6 29.3 o o Rv2938 6 29.6 o o Rv2399c...”
- Characterization of a Clp protease gene regulator and the reaeration response in Mycobacterium tuberculosis
Sherrid, PloS one 2010 - “...hypothetical protein Rv1234 transmembrane protein Rv3177 Peroxidase Rv1235 sugar-binding lipoprotein lpqY Rv3188 conserved hypothetical protein Rv1236 sugar-transport membrane protein ABC transporter sugA Rv3189 conserved hypothetical protein Rv1259 uracil dna glycosylase Rv3201c ATP-dependent DNA helicase Rv1286 sulfate adenyltransferase/adenylylsulfate kinase Rv3205c conserved hypothetical protein Rv1472 enoyl-CoA hydratase echA12...”
- “.... Reaeration Response genes involved in metabolic adaptation include a sugar transporter ( Rv1235 and Rv1236 ) predicted to be essential for MTB survival in macrophages and mice [29] [30] , the triacylglycerol lipase lipY ( Rv3097c ), recently shown to cleave triacylglycerides upon reaeration, and...”
- Development and analysis of an in vivo-compatible metabolic network of Mycobacterium tuberculosis
Fang, BMC systems biology 2010 - “...phenol phthiocerol dimycocerosate to the biomass objective function [ 62 ] 27 32 33 34 Rv1236 Rv1237 Rv1238 sugA sugB sugC FN Transport Transport of glucose, maltoheptaose, maltose, ribose, trehalose, and xylose into cell (1) Allowed xylose uptake and added xylose to the biomass objective function...”
- More
- Circulating Mycobacterium bovis peptides and host response proteins as biomarkers for unambiguous detection of subclinical infection
Lamont, Journal of clinical microbiology 2014 - “...MB2122c MB1672c MB1554c (pks5) MB1895c MB3729c MB1268 MB3017c Transcriptional regulator (LuxR family) Methyltransferase activity Glucose metabolism Aldehyde...”
7cagA / A0R2C2 Mycobacterium smegmatis lpqy-sugabc complex in the catalytic intermediate state (see paper)
38% identity, 90% coverage
- Ligand: alpha-d-glucopyranose (7cagA)
Q49976 Malf from Mycobacterium leprae
37% identity, 94% coverage
- Microarray analysis of iron deficiency chlorosis in near-isogenic soybean lines.
O'Rourke, BMC genomics 2007 - “...0.0078 GmTC214121 Q9FE67 Ethylene Responsive Transcription Factor/Ubiquitin 2Fe, 8PS, 33ST/2Fe 1.00E-24/2.00E-64 Gm-c1028-6890 5.219 0.0163 GmTC214518 Q49976 Ubiquitin 2Fe 2.00E-63 Gm-c1028-8604 2.821 0.0935 GmTC228370 Q9AXD7 Response Regulator Protein (ARR) 1Fe, 1PS, 7ST 1.00E-49 Gm-c1028-8161 2.827 0.0246 GmTC205220 Q69IX0 RER1A 1Fe, 1PS 1.00E-67 Gm-c1028-6556 2.891 0.0340 GmTC228039 Q75HJ3...”
ML1087 probable ABC-transport protein, inner membrane component from Mycobacterium leprae TN
37% identity, 94% coverage
- Mycobacterium leprae Transcriptome During In Vivo Growth and Ex Vivo Stationary Phases
Ojo, Frontiers in cellular and infection microbiology 2021 - “...expression when compared to MFP5 ( Figure3E ). Many of the sugar transporters like sugA (ML1087), sugB (ML1088) and sugC (ML1089) were down regulated in ML96 along with uspE (ML1769), uspC (ML1770) and mmpL10 (ML1231). ML0283, a possible cation-efflux transporter was significantly upregulated at 96 hr...”
smoG / Q7CS30 ABC-type 3-(6-sulfo-α-D-quinovosyl)-sn-glycerol transporter permease subunit from Agrobacterium fabrum (strain C58 / ATCC 33970) (see paper)
Atu3283 ABC transporter, membrane spanning protein (sugar) from Agrobacterium tumefaciens str. C58 (Cereon)
36% identity, 83% coverage
- Oxidative desulfurization pathway for complete catabolism of sulfoquinovose by bacteria
Sharma, Proceedings of the National Academy of Sciences of the United States of America 2022 - “...of genes ( Atu3277 - Atu3285 ) for cells grown on SQ. Proteins encoded by Atu3283 and Atu3284 were not observed; however, they are predicted to be integral membrane proteins that can be difficult to detect using conventional proteomic workflows ( 14 ). Thus, the gene...”
- “...Protein that Binds SQGro. Within the gene cluster identified through proteomics, Atu3281 ( smoE ), Atu3283 ( smoG ), and Atu3284 ( smoH ) were annotated as an ABC transporter system, with Atu3282 ( smoF ) encoding an associated periplasmic solute-binding protein. The substrate preferences of...”
MAV_1375 ABC transporter, permease protein SugA from Mycobacterium avium 104
36% identity, 93% coverage
- The recombination-cold region as an epidemiological marker of recombinogenic opportunistic pathogen Mycobacterium avium
Yano, BMC genomics 2019 - “...members of SC2 and SC4, c Maximum likelihood tree based on the alignment of the MAV_1375 ortholog. GTR+G was used as the model, d Selected polymorphic sites in the alignment of the MAV_1375 ortholog We next investigated whether the allele types of the MAH_0788 ortholog could...”
- “...SNPs unique to these members were present. After manual screening for recombination-free regions, two loci, MAV_1375 (TH135 locus_tag MAH_1236, sugA gene, product name of trehalose ABC transporter) (Fig. 3 C) and MAV_2820 (TH135 locus_tag MAH_2466, product name of short chain dehydrogenase) (Additional file 3 ), were...”
MAH_1236 carbohydrate ABC transporter permease from Mycobacterium avium subsp. hominissuis TH135
36% identity, 93% coverage
- The recombination-cold region as an epidemiological marker of recombinogenic opportunistic pathogen Mycobacterium avium
Yano, BMC genomics 2019 - “...these members were present. After manual screening for recombination-free regions, two loci, MAV_1375 (TH135 locus_tag MAH_1236, sugA gene, product name of trehalose ABC transporter) (Fig. 3 C) and MAV_2820 (TH135 locus_tag MAH_2466, product name of short chain dehydrogenase) (Additional file 3 ), were found to contain...”
- “...P-450 (locus_tags: MAH_0788, MAV_0940) and the sugA gene encoding the trehalose ABC transporter (locus tags: MAH_1236, MAV_1375), could additively inform the core genome lineage (or association of BAPS subpopulations) of MAH isolates as well as M. avium subspecies. Features around the recombination-cold region Rare occurrences of...”
SCO1057 sugar transport integral membrane protein from Streptomyces coelicolor A3(2)
32% identity, 98% coverage
pRL120007 putative permease component of ABC transporter from Rhizobium leguminosarum bv. viciae 3841
32% identity, 100% coverage
PM1761 unknown from Pasteurella multocida subsp. multocida str. Pm70
32% identity, 89% coverage
SMb21149 putative sugar uptake ABC transporter permease protein from Sinorhizobium meliloti 1021
31% identity, 91% coverage
SM_b21220 ABC transporter for D-Glucosamine, permease component 2 from Sinorhizobium meliloti 1021
38% identity, 85% coverage
- mutant phenotype: Specific phenotypes on D-Glucosamine Hydrochloride.
AT5A_09940 carbohydrate ABC transporter permease from Agrobacterium tumefaciens 5A
32% identity, 86% coverage
- Introducing the ArsR-Regulated Arsenic Stimulon
Rawle, Frontiers in microbiology 2021 - “...nucleotide-binding 2.4 AT5A_03260 Sugar ABC transporter ATPase 2.6 AT5A_09935 Sugar ABC transporter substrate-binding protein 2.6 AT5A_09940 Sugar ABC transporter transmembrane protein 2.3 AT5A_09945 Sugar ABC transporter transmembrane protein 2.1 AT5A_09950 Sugar ABC transporter nucleotide-binding ATPase 2.2 AT5A_18906 Maltose ABC transporter transmembrane protein 2.4 AT5A_18911 Maltose ABC...”
AT5A_18906 carbohydrate ABC transporter permease from Agrobacterium tumefaciens 5A
33% identity, 90% coverage
- Introducing the ArsR-Regulated Arsenic Stimulon
Rawle, Frontiers in microbiology 2021 - “...2.3 AT5A_09945 Sugar ABC transporter transmembrane protein 2.1 AT5A_09950 Sugar ABC transporter nucleotide-binding ATPase 2.2 AT5A_18906 Maltose ABC transporter transmembrane protein 2.4 AT5A_18911 Maltose ABC transporter transmembrane protein 2.4 AT5A_18916 Maltose ABC transporter substrate-binding protein 2.7 AT5A_18921 Maltose/maltodextrin ABC transporter 2.7 AT5A_19366 Sugar ABC transporter periplasmic...”
HVO_A0147 ABC-type transport system permease protein (probable substrate sugar) from Haloferax volcanii DS2
39% identity, 72% coverage
- Assigning a function to a conserved archaeal metallo-β-lactamase from Haloferax volcanii
Fischer, Extremophiles : life under extreme conditions 2012 - “...276.0 1445.0 9.55E16 2.39 Downregulated HVO_A0146 ABC-type sugar transport protein (permease) 741.0 173.0 2.05E11 2.10 HVO_A0147 ABC-type sugar transport protein (permease) 837.0 270.0 2.11E13 1.64 HVO_A0149 Glucan 1,4--glucosidase 744.6 255.0 8.27E22 1.55 HVO_A0148 ABC-type sugar transport system, periplasmic substrate-binding protein 784.8 291.1 3.12E17 1.43 HVO_2401 Glycine...”
- “...blot, the mRNA is approximately 5.000nt long, which suggests that the four genes HVO_A0145, HVO_A0146, HVO_A0147 and HVO_A0148 are expressed as one multicistronic mRNA (the open reading frames are altogether 4.7-kb long). b Expression of the glucan 1,4--glucosidase (HVO_A0149) mRNA. The mRNA for the HVO_A0149 gene...”
SP_1689 carbohydrate ABC transporter permease from Streptococcus pneumoniae TIGR4
30% identity, 89% coverage
- Multi-omic profiling to assess the effect of iron starvation in Streptococcus pneumoniae TIGR4
Jiménez-Munguía, PeerJ 2018 - “...Downregulated 38765 SP_1465, SP_1466 2/2 Downregulated 38778 SP_1522, SP_1523 2/7 Downregulated 38815 SP_1686, SP_1687, SP_1688, SP_1689 4/4 Downregulated 38822 SP_1724, SP_1725 2/2 Downregulated 38840 SP_1809, SP_1810 2/2 Downregulated 38867 SP_1920, SP_1922 2/3 Downregulated 38868 SP_1923, SP_1924, SP_1925, SP_1926 4/4 Downregulated 38873 SP_1948, SP_1949 2/2 Downregulated 38874...”
Rv2040c Probable sugar-transport integral membrane protein ABC transporter from Mycobacterium tuberculosis H37Rv
MT2100 sugar ABC transporter, permease protein from Mycobacterium tuberculosis CDC1551
34% identity, 87% coverage
- Identification of positively selected genes in Mycobacterium tuberculosis from southern Xinjiang Uygur autonomous region of China
Deng, Frontiers in microbiology 2024 - “...transcriptional regulator M1a_M2a katG a , b Rv1908c 62 56 5 11 Catalase-peroxidase M1a_M2a M7_M8 Rv2040c Rv2040c 7 5 1 1 Sugar ABC transporter permease M7_M8 pncA a , b Rv2043c 33 25 6 2 Pyrazinamidase/nicotinamidase PncA M1a_M2a M7_M8 pks12 a Rv2048c 148 86 62 14...”
- Prolonged survival of a patient with active MDR-TB HIV co-morbidity: insights from a Mycobacterium tuberculosis strain with a unique genomic deletion
Rubinstein, Frontiers in medicine 2023 - “...severely affected the pathogens proliferation inside the host. Two of the deleted genes, Rv2028 and Rv2040c, have been previously identified in a comprehensive screen for genes that are important for in-host survival ( 48 ). acg has also been shown to be an essential virulence factor,...”
- Comparison of carbohydrate ABC importers from Mycobacterium tuberculosis
De, BMC genomics 2021 - “...Group 1 was formed by SugB, Rv2039c, UspB, and UgpE and group 2 by SugA, Rv2040c, UspA, and UgpA. Putative orthologs of SugAB permeases formed a separated group from the three other systems, as shown in SugC NBD group (Fig. 2 A). According to the alignments,...”
- “...member of each transporter. Group 1: SugB, Rv2039c, UspB, and UgpE, and Group 2: SugA, Rv2040c, UspA, and UgpA. Dark gray: M. tuberculosis complex group (MTBC), light gray: other pathogenic mycobacteria, and white: environmental species, represented by M. smegmatis. The amino acid sequences of TTH_RS04960 and...”
- Transcriptional Profiling of Mycobacterium tuberculosis Exposed to In Vitro Lysosomal Stress
Lin, Infection and immunity 2016 - “...Rv1877 Rv1922 Rv1946c Rv1964 Rv1979c Rv1986 Rv2037c Rv2040c Rv2041c Rv2273 Rv2281 Rv2398c Rv2400c Rv2522c Rv2835c MT3080 MT3951 Rv3000 Rv3843c MT0691 MT0699...”
- Anti-mycobacterial activity of marine fungus-derived 4-deoxybostrycin and nigrosporin
Wang, Molecules (Basel, Switzerland) 2013 - “...0.07 Metabolism: Carbohydrate transport and metabolism Rv2471 - 1.83 0.12 Metabolism: Carbohydrate transport and metabolism Rv2040c - 2.11 0.19 Metabolism: Carbohydrate transport and metabolism panB Rv2225 0.52 0.03 Metabolism: Coenzyme metabolism Rv1335 - 1.66 0.04 Metabolism: Coenzyme metabolism nadA Rv1594 1.73 0.09 Metabolism: Coenzyme metabolism cobU...”
- “...1.243 1.01 0.964 0.739 0.933 0.961 Rv0282 Rv3673c Rv3132c cobU narL rplT cysA rplQ fadD32 Rv2040c Rv1354c Rv1200 1.989 9.219 0.742 0.919 0.937 0.728 0.805 0.807 1 0.817 0.801 0.924 Rv3044 Rv1372 Rv1257c htpX pgk ctaC infB rpsD ogt Rv2264c Rv0907 Rv1335 15.46 0.59 1.023 0.846...”
- Reprogramming the Mycobacterium tuberculosis transcriptome during pathogenesis
Waddell, Drug discovery today. Disease mechanisms 2010 - “...[ 2 ]. By contrast, the predicted carbohydrate transporters of unknown specificity ( sugI , Rv2040c and Rv2041c ) were induced on macrophage infection [ 2 , 3 ], highlighting that the acquisition (or export) of carbohydrate moieties may still be important for successful infection. Genes...”
- Transcriptional Profiling of Mycobacterium tuberculosis Exposed to In Vitro Lysosomal Stress
Lin, Infection and immunity 2016 - “...MT1642 MT1926 MT1973 MT1997 MT2016 MT2031 MT2040 MT2097 MT2100 MT2101 MT2334 MT2339 MT2469 MT2471 MT2598 MT2901 Rv1607 Rv1877 Rv1922 Rv1946c Rv1964 Rv1979c...”
SPD_1501 ABC transporter, permease protein from Streptococcus pneumoniae D39
30% identity, 89% coverage
SGO_0121 ABC transporter permease protein SP1689 from Streptococcus gordonii str. Challis substr. CH1
30% identity, 89% coverage
B9H01_RS00985, BFP66_RS00850 carbohydrate ABC transporter permease from Streptococcus suis
32% identity, 82% coverage
Balac_0515 putative binding protein-dependent transporter from Bifidobacterium animalis subsp. lactis Bl-04
30% identity, 89% coverage
RUMGNA_02697 hypothetical protein from Ruminococcus gnavus ATCC 29149
32% identity, 80% coverage
- The mucin-degradation strategy of Ruminococcus gnavus: The importance of intramolecular trans-sialidases
Crost, Gut microbes 2016 - “...the ABC transporter composed of a solute-binding protein (RUMGNA_02698 or RGNV35913_01296) and two putative permeases (RUMGNA_02697 and RUMGNA_02696, or RGNV35913_01295 and RGNV35913_01294) ( Fig.5A ). It is not known whether this transporter is specific of the 2,7-anhydro-Neu5Ac or could also transport Neu5Ac. Once inside the cell,...”
- “...of a solute-binding protein (RUMGNA_02698 in ATCC 29149;RGNV35913_01296 in ATCC 35913) and two putative permeases (RUMGNA_02697 and RUMGNA_02696 in ATCC 29149; RGNV35913_01295 and RGNV35913_01294 in ATCC 35913) and then hydrolyzed into Neu5Ac, possibly by the action of RUMGNA_02701 or RGNV35913_01299, before being catabolized into GlcNAc-6-P following...”
- Utilisation of mucin glycans by the human gut symbiont Ruminococcus gnavus is strain-dependent
Crost, PloS one 2013 - “...The following 3 genes code for a predicted solute-binding protein (RUMGNA_02698) and two putative permeases (RUMGNA_02697, RUMGNA_02696), components of a sugar ABC transporter; RUMGNA_02696gp has specific homology with putative sialic acid transporters of the SAT2 family [54] . The following gene has no known function. The...”
MAP1768c hypothetical protein from Mycobacterium avium subsp. paratuberculosis str. k10
34% identity, 84% coverage
Cthe_1019 binding-protein-dependent transport systems inner membrane component from Clostridium thermocellum ATCC 27405
Cthe_1019 carbohydrate ABC transporter permease from Acetivibrio thermocellus ATCC 27405
31% identity, 87% coverage
- Utilization of Monosaccharides by Hungateiclostridium thermocellum ATCC 27405 through Adaptive Evolution
Ha-Tran, Microorganisms 2021 - “...in FAs1 and GAs1 ( Figure 4 ). Additionally, the transmembrane sugar transport protein msdB1 (Cthe_1019) in the CbpB operon also exhibited an upregulated expression level. As CbpC transport proteins can bind to glucose [ 63 ], it was not surprising that two of four genes...”
- Integrated omics analyses reveal the details of metabolic adaptation of Clostridium thermocellum to lignocellulose-derived growth inhibitors released during the deconstruction of switchgrass
Poudel, Biotechnology for biofuels 2017 - “...[ 43 ]. Out of seven detected cellodextrin ABC transporter components, three (Cthe_1862, Cthe_1020, and Cthe_1019) were classified into cluster 4, whereas Cthe_0393 was a member of cluster 3. This suggests the majority of proteins required for the cellodextrin uptake remain relatively constant, with a modest...”
- “...spectrometry but were not significantly changing over time. 1. Cellulosomes ; 2. Cellodextrin ABC transporters Cthe_1019, 1020, 1862; 3. Cellodextrin phosphorylase Cthe_2989; 4. Phosphoglucomutase Cthe_1265; 5. Glucokinase Cthe_0390; 6. Gluco - 6 - P - Isomerase Cthe_0217; 7. Phosphofructokinase Cthe_0347; 8. Fructose - bis - P...”
CPE0372 probable ABC transporter from Clostridium perfringens str. 13
34% identity, 70% coverage
AT5A_22281 carbohydrate ABC transporter permease from Agrobacterium tumefaciens 5A
34% identity, 76% coverage
- Introducing the ArsR-Regulated Arsenic Stimulon
Rawle, Frontiers in microbiology 2021 - “...transporter ATP-binding protein 2.2 2.5 17.2 33.6 2.1 2.0 AT5A_19781 Ribose ABC transporter transmembrane protein AT5A_22281 Sugar ABC transporter permease 2.4 AT5A_22286 Sugar ABC transporter substrate-binding protein 2.4 AT5A_24025 Sugar ABC transporter substrate-binding protein 2.3 2.6 2.2 AT5A_24035 Sugar ABC transporter nucleotide ATPase 2.0 2.6 2.2...”
BAD_RS02260 carbohydrate ABC transporter permease from Bifidobacterium adolescentis ATCC 15703
30% identity, 85% coverage
- Combining of transcriptome and metabolome analyses for understanding the utilization and metabolic pathways of Xylo-oligosaccharide in Bifidobacterium adolescentis ATCC 15703
Yang, Food science & nutrition 2019 - “...sequence Tm Length (bp) BAD_RS02255 Sugar ABC transporter substratebinding protein F:AGGAAGGTGCTTTGATGGG 57.2 116 R:GGCGTATTTCTCCTGATTTGA 57.2 BAD_RS02260 Sugar ABC transporter permease F:CTTCGTGCCGTATGTCGTTT 58.7 246 R:TGGCTGCTTCATACAGTTCC 57.9 BAD_RS00875 Phosphoenolpyruvateprotein phosphotransferase F:TGTTCCGTACCGAATTCCTGT 59.5 117 R:TGCGGATCACGACCTTCTT 58.5 BAD_RS01940 PTS betaglucoside transporter subunit EIIBCA F:ACGCTCGGCTACGACTTCAT 59.9 200 R:AGCTTGTACCGCAGGTGGAT 58.5 BAD_RS06365 Betaglucosidase...”
- “...transporter substratebinding protein 30.52 6.05 BAD_RS02265 2.38 yurM Thiamine ABC transporter ATPbinding protein 2,679.25 514.59 BAD_RS02260 2.34 malF Sugar ABC transporter permease 2,356.22 466 BAD_RS00385 2.28 livF ABCtype branchedchain amino acid transport systems ATPase component 25.2 5.2 BAD_RS08210 1.99 amyD Permease of ABC transporter possibly for...”
Gocc_2321 carbohydrate ABC transporter permease from Gaiella occulta
31% identity, 88% coverage
mlr7226 sugar ABC transporter, permease protein from Mesorhizobium loti MAFF303099
27% identity, 90% coverage
SYNW1283 ABC transporter for possibly for trehalose/maltose, membrane component from Synechococcus sp. WH 8102
36% identity, 77% coverage
- Computational prediction of the osmoregulation network in Synechococcus sp. WH8102
Mao, BMC genomics 2010 - “...SYNW1279-1286 0.99 PCC6803 slr0746 GgpP SYNW0860 PCC6803 slr0747 GgtA SYNW1285 SYNW1279-1286 0.99 PCC6803 slr0530 GgtC SYNW1283 SYNW1279-1286 0.99 PCC6803 slr0531 GgtD SYNW1284 SYNW1279-1286 0.99 PCC6803 ABX75857 GpgS SYNW2436 P.marina ABX75858 GpgP SYNW2434 P.marina slr0662 SpeA SYNW2359 0.99 PCC6803 sll0045 Sps SYNW2520 0.69 PCC6803 b0855 PotG SYNW1544...”
- Operon prediction by comparative genomics: an application to the Synechococcus sp. WH8102 genome
Chen, Nucleic acids research 2004 - “...(SYNW0969, (SYNW1086, (SYNW1111, (SYNW1168, (SYNW1270, (SYNW1283, (SYNW1340, (SYNW1415, (SYNW1797, (SYNW1857, (SYNW1915, (SYNW2393, (SYNW2438, (SYNW2479,...”
YPTB1914 ABC sugar (sorbitol/trehalose/maltose) transporter, permease subunit from Yersinia pseudotuberculosis IP 32953
34% identity, 75% coverage
- Genome-wide assessment of antimicrobial tolerance in Yersinia pseudotuberculosis under ciprofloxacin stress
Willcocks, Microbial genomics 2019 - “...guanylyltransferase YPTB1012 wbyL Probable glycosyltransferase YPTB1453 ompA Outer membrane protein YPTB1622 pagP Lipid A palmitoyltransferase YPTB1914 YPTB1914 ABC sugar (sorbitol/trehalose/maltose) transporter, permease subunit YPTB2014 YPTB2014 Putative ABC transporter YPTB2327 pmrJ Probable 4-deoxy-4-formamido- l -arabinose-phosphoundecaprenol deformylase YPTB3041 ygeD Lysophospholipid transporter YPTB3407 rfaE Bifunctional protein - ADP- l...”
Q6MNM0 ABC-type maltose transporter (EC 7.5.2.1) from Bdellovibrio bacteriovorus (see paper)
TC 3.A.1.1.51 / Q6MNM0 Maltose - maltoheptose transporter, MalEFGK from Bdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIB 9529 / HD100)
28% identity, 38% coverage
- substrates: Maltoheptose, Maltohexose, Maltopentose, Maltose, Maltotetrose, Maltotriose, Trehalose
tcdb comment: MalEF is a R-M fusion protein with the MalE domain N-terminal and the MalF domain C-terminal. The protein, of 733 aas, has 8 TMSs, one N-terminal to MalE (a signal sequence for export of the MalE domain to the periplasm), an extra TMS at the N-terminus to bring the N-terminus to the periplasmic side of the inner membrane, and then the usual 6 TMSs observed for most ABC membrane proteins. MalG (M, 272 aas, 6 TMSs) and MalK (C, 374 aas) are of normal size and composition. While MalE of E. coli was able to additionally increase ATPase activity of MalFGK2Bb in vitro, the isolated MalE domain of B. bacteriovorus failed to stimulate the E. coli system (Licht et al. 2018)
B8809_1436 carbohydrate ABC transporter permease from Bifidobacterium longum subsp. longum
32% identity, 71% coverage
pRL120557 putative transmembrane permease transporter component from Rhizobium leguminosarum bv. viciae 3841
28% identity, 87% coverage
TC 3.A.1.1.37 / Q9WYB4 Predicted arabinoside porter. Regulated by arabinose-responsive regulator AraR from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
TM0278 sugar ABC transporter, permease protein from Thermotoga maritima MSB8
32% identity, 86% coverage
SCO0532 sugar transporter membrane protein from Streptomyces coelicolor A3(2)
31% identity, 87% coverage
blr3567 ABC transporter permease protein from Bradyrhizobium japonicum USDA 110
30% identity, 91% coverage
- Growth Rate of and Gene Expression in Bradyrhizobium diazoefficiens USDA110 due to a Mutation in blr7984, a TetR Family Transcriptional Regulator Gene
Ohkama-Ohtsu, Microbes and environments 2016 - “...free-living blr7984 mutant cells ( Table 2 ). Five genes induced in the cluster, blr3566, blr3567, blr3568, blr3570, and blr3571, encoded proteins for ABC transport systems, which uptake substances in cells using energy from ATP hydrolysis. Three genes, blr3573, blr3574, and blr3575, induced in the cluster...”
- “...free-living (blr7984/wild-type) Cluster * bll7983 glutathione transferase 48.9 blr3566 ABC transporter substrate-binding protein 24.3 B blr3567 ABC transporter permease 22.2 B bll7982 hypothetical protein 20.3 blr3568 ABC transporter permease 19.5 B bll7981 dehydrogenase 18.2 blr3571 ABC transporter ATP-binding protein 17.4 B bsr3569 hypothetical protein 16.7 B...”
BruAb2_0483 hypothetical sugar ABC transporter, permease protein from Brucella abortus biovar 1 str. 9-941
30% identity, 87% coverage
- Molecular targets for rapid identification of Brucella spp
Ratushna, BMC microbiology 2006 - “..... 618876) BruAb2_0590 598292 .. 599416 1203/1125 beta-ketoadipyl CoA thiolase 2 BRA0749 731323 .. 732192 BruAb2_0483 (484959 .. 485828) 870 sugar ABC transporter, permease protein, putative 2 BRA0907 888804 .. 890204 BruAb2_0326 (326911 .. 328311) 1401 conserved hypothetical protein 2 BRA1096 1082617 .. 1083330 BruAb2_1035 1037839...”
XF2447 ABC transporter sugar permease from Xylella fastidiosa 9a5c
31% identity, 89% coverage
MSMEG_3267 transporter from Mycobacterium smegmatis str. MC2 155
33% identity, 82% coverage
C289_0779 carbohydrate ABC transporter permease from Anoxybacillus ayderensis
32% identity, 76% coverage
- A high molecular-mass Anoxybacillus sp. SK3-4 amylopullulanase: characterization and its relationship in carbohydrate utilization
Kahar, International journal of molecular sciences 2013 - “...C289_1909, and C289_2139). Several putative sugar transporters (C289_0465, C289_0466, C289_0467, C289_0603, C289_0763, C289_0764, C289_0765, C289_0778, C289_0779, C289_0780, C289_1015, C289_1174, C289_1392, C289_1394, C289_1910, C289_1911, and C289_1912) were also found in the Blast2GO annotation. The draft genome was submitted to the National Center for Biotechnology Information (NCBI) Bioproject...”
BCAN_B0756 binding-protein-dependent transport systems inner membrane component from Brucella canis ATCC 23365
BRA0749 sugar ABC transporter, permease protein, putative from Brucella suis 1330
30% identity, 87% coverage
- ATP-Binding Cassette Systems of Brucella
Jenner, Comparative and functional genomics 2009 - “...IM BMEII0541 BruAb20483 BRA0749 BOV_A0700 BCAN_B0757 OSP Oligosaccharide or polyol import IM BruAb20482 BRA0750 BOV_A0699 BCAN_B0756 OSP Oligosaccharide or polyol import BP BMEII0542 BruAb20484 BRA0748 BOV_A0698 BCAN_B0755 OSP Oligosaccharide or polyol import ABC BMEII0544 BruAb20487 BRA0745 BOV_A0696 BCAN_B0753 78 OSP Oligosaccharide or polyol import BP BMEII0590...”
- ATP-Binding Cassette Systems of Brucella
Jenner, Comparative and functional genomics 2009 - “...import BP BMEII0115 BruAb21116 BRA1180 BCAN_B1211 77 OSP Oligosaccharide or polyol import IM BMEII0541 BruAb20483 BRA0749 BOV_A0700 BCAN_B0757 OSP Oligosaccharide or polyol import IM BruAb20482 BRA0750 BOV_A0699 BCAN_B0756 OSP Oligosaccharide or polyol import BP BMEII0542 BruAb20484 BRA0748 BOV_A0698 BCAN_B0755 OSP Oligosaccharide or polyol import ABC BMEII0544...”
- Molecular targets for rapid identification of Brucella spp
Ratushna, BMC microbiology 2006 - “...protein 2 BRA0636 (617674 .. 618876) BruAb2_0590 598292 .. 599416 1203/1125 beta-ketoadipyl CoA thiolase 2 BRA0749 731323 .. 732192 BruAb2_0483 (484959 .. 485828) 870 sugar ABC transporter, permease protein, putative 2 BRA0907 888804 .. 890204 BruAb2_0326 (326911 .. 328311) 1401 conserved hypothetical protein 2 BRA1096 1082617...”
- The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts
Paulsen, Proceedings of the National Academy of Sciences of the United States of America 2002 - “...BR0404 BR0391 BR0355 BR0389, BR0390 BR0221 BRA0631-BRA0635 BRA0749, BRA0750 BRA0907 BRA1080 BRA1096 Unique B. melitensis regions 107 764 276 238 845...”
alr0789 ABC transporter sugar permease from Nostoc sp. PCC 7120
34% identity, 81% coverage
- Chemoheterotrophic growth of the Cyanobacterium Anabaena sp. strain PCC 7120 dependent on a functional cytochrome c oxidase
Stebegg, Journal of bacteriology 2012 - “...all1027, all1823, all1916, all4824, all5282, alr0738, alr0789, alr2532, alr2722, alr3705, alr4277, alr4781, alr5362, alr5367, and alr5368) are currently...”
RL2896 putative transmembrane transporter from Rhizobium leguminosarum bv. viciae 3841
29% identity, 91% coverage
SUB0163 binding-protein-dependent transport system membrane protein from Streptococcus uberis 0140J
30% identity, 90% coverage
BP2830 putative ABC transport protein, inner mebrane component from Bordetella pertussis Tohama I
32% identity, 82% coverage
ECs1890 putative binding-protein dependent transport protein from Escherichia coli O157:H7 str. Sakai
30% identity, 86% coverage
lmo0766 similar to putative sugar ABC transporter, permease protein from Listeria monocytogenes EGD-e
30% identity, 91% coverage
BOV_A0699 putative sugar ABC transporter, permease protein from Brucella ovis ATCC 25840
29% identity, 87% coverage
- ATP-Binding Cassette Systems of Brucella
Jenner, Comparative and functional genomics 2009 - “...import IM BMEII0541 BruAb20483 BRA0749 BOV_A0700 BCAN_B0757 OSP Oligosaccharide or polyol import IM BruAb20482 BRA0750 BOV_A0699 BCAN_B0756 OSP Oligosaccharide or polyol import BP BMEII0542 BruAb20484 BRA0748 BOV_A0698 BCAN_B0755 OSP Oligosaccharide or polyol import ABC BMEII0544 BruAb20487 BRA0745 BOV_A0696 BCAN_B0753 78 OSP Oligosaccharide or polyol import BP...”
SCO7012 binding protein dependent transport protein from Streptomyces coelicolor A3(2)
28% identity, 85% coverage
PD1465 ABC transporter sugar permease from Xylella fastidiosa Temecula1
30% identity, 88% coverage
- Xylella fastidiosa: Host Range and Advance in Molecular Identification Techniques
Baldi, Frontiers in plant science 2017 - “...e PD1840 CCAAACATAGAAGCACGCCG CGTATGTCTGTGCGGTGTG Siroheme synthase leuA e PD1047 GGCCAGTGCTGTGTTTTGTT GGGCTACTTGCTGGAGGAAG 2-Isopropylmalate synthase lacF e PD1465 TTCTTTGGTGGGTTGGGTGT CACACAGCATCAACGTCGTC ABC transporter sugar permease a Schuenzel et al. ( 2005 ) . b Almeida et al. ( 2008 ) . c Yuan et al. ( 2010 ) ....”
LMOf2365_0190 sugar ABC transporter, permease protein from Listeria monocytogenes str. 4b F2365
lmo0179 similar to sugar ABC transporters, permease proteins from Listeria monocytogenes EGD-e
29% identity, 82% coverage
YcjO / b1311 putative ABC transporter membrane subunit YcjO from Escherichia coli K-12 substr. MG1655 (see 2 papers)
TC 3.A.1.1.46 / P0AFR7 Inner membrane ABC transporter permease protein YcjO, component of Probable glucoside uptake porter, YcjNOPV from Escherichia coli (strain K12)
b1311 predicted sugar transporter subunit: membrane component of ABC superfamily from Escherichia coli str. K-12 substr. MG1655
S1400 putative binding-protein dependent transport protein from Shigella flexneri 2a str. 2457T
29% identity, 86% coverage
- substrates: Glucosides
tcdb comment: Encoded in an operon or gene cluster with a glucosyl hydrolase and two oxidoreductases (Moussatova et al. 2008) - Co-translational protein aggregation and ribosome stalling as a broad-spectrum antibacterial mechanism
Khodaparast, Nature communications 2025 (no snippet) - 18th Congress of the European Hematology Association, Stockholm, Sweden, June 13–16, 2013
, Haematologica 2013 - luxS-dependent gene regulation in Escherichia coli K-12 revealed by genomic expression profiling
Wang, Journal of bacteriology 2005 - “...b3906 b2060 b0790 b1720 b1010 b2797 b2993 b0042 b1001 b2549 b1311 b3141 b1012 b1571 lsrG lsrD lsrA lsrB metE lsrF lsrK yneE yfaE tam yjhR lsrR lsrC gpmB argX...”
- Probiotics and Postbiotics as Substitutes of Antibiotics in Farm Animals: A Review
Zamojska, Animals : an open access journal from MDPI 2021 - “...Carter A. Adams M. La Ragione R.M. Woodward M.J. Colonisation of poultry by Salmonella Enteritidis S1400 is reduced by combined administration of Lactobacillus salivarius 59 and Enterococcus faecium PXN-33 Vet. Microbiol. 2017 199 100 107 10.1016/j.vetmic.2016.12.029 28110775 31. Wang J. Wan C. Shuju Z. Yang Z....”
- “...salivarius 59 and Enterococcus faecium PXN33/probiotic per os in feed Decreased colonization by Salmonella Enteritidis S1400 [ 30 ] E. faecium /probiotic per os in feed Increased egg weight, serum FSH * levels, decreased Bacteroidetes [ 31 ] Bacillus subtilis C-3102/probiotic per os in feed Reduction...”
- Phosphorylation-Mediated Molecular Pathway Changes in Human Pituitary Neuroendocrine Tumors Identified by Quantitative Phosphoproteomics
Li, Cells 2021 - “...(ID: P35658), Thr1399 (ratio of T/N = 3.36, p = 3.84 10 6 ), and S1400 (ratio of T/N = 3.15, p = 4.81 10 5 ) in NPC-RanBP2 (ID: P49792), S28 (ratio of T/N = 1.41, p = 7.09 10 3 ) in survival motor...”
- Benefits and Inputs From Lactic Acid Bacteria and Their Bacteriocins as Alternatives to Antibiotic Growth Promoters During Food-Animal Production
Vieco-Saiz, Frontiers in microbiology 2019 - “...10 7 CFU/mL of Lb. salivarius 59 and Ent. faecium PXN33 by reducing Salmonella Enteritidis S1400 colonization in chicks. Penha Filho et al. (2015) reported the effect of 1 10 5 CFU of a Lb. -based probiotic suspension on reducing Salmonella colonization when this strain was...”
- “...Ragione R. M. Woodward M. J. ( 2017 ). Colonisation of poultry by Salmonella Enteritidis S1400 is reduced by combined administration of Lactobacillus salivarius 59 and Enterococcus faecium PXN-33. Vet. Microbiol. 199 100 107 . 10.1016/j.vetmic.2016.12.029 28110775 Cavera V. L. Arthur T. D. Kashtanov D. Chikindas...”
- The Biological Fight Against Pathogenic Bacteria and Protozoa
Villa, New Weapons to Control Bacterial Growth 2016 - “...E. coli O157:H7, C. difficile DSM1296, C. perfringens DSM11780, S typhimurium 3530, and Salmonella enteritidis S1400 (Thapa et al. 2012 ). Fig.1 Chemical structure of LFF571. LFF571, a semisynthetic thiopeptide (see Selva et al. 1991 ) Gastroesophageal reflux disease is a common condition that, according to...”
- Genomic and proteomic characterization of the broad-host-range Salmonella phage PVP-SE1: creation of a new phage genus
Santos, Journal of virology 2011 - “...The phage host, Salmonella enterica serovar Enteritidis strain S1400, belongs to the University of Bristol's private collection (64). The rough and deep rough...”
- “...agar plates using a standard procedure (60), with strain S1400 as a host. Phage particles were subsequently collected by adding 5 ml of SM buffer (100 mM...”
Csac_0427 binding-protein-dependent transport systems inner membrane component from Caldicellulosiruptor saccharolyticus DSM 8903
29% identity, 92% coverage
Dshi_0548 ABC transporter for Xylitol, permease component 1 from Dinoroseobacter shibae DFL-12
31% identity, 83% coverage
- mutant phenotype: Specific phenotypes on Xylitol; Xylitol. Phenotype is very specific
SMc01627 PUTATIVE PERMEASE ABC TRANSPORTER PROTEIN from Sinorhizobium meliloti 1021
31% identity, 92% coverage
- The transport of mannitol in Sinorhizobium meliloti is carried out by a broad-substrate polyol transporter SmoEFGK and is affected by the ability to transport and metabolize fructose
Kohlmeier, Microbiology (Reading, England) 2023 - “...r [ 40 ] FL4643 RmP110 mtlK ::pTH1522, Gm r [ 39 ] SRmA723 Rm1021 SMc01627 ::Tn 5 -233, Gm r Sp r [ 45 ] SRmD491 Rm1021 smoE ::Tn 5 -B20, Nm r [ 36 ] SRmD492 Rm1021 smoF ::Tn 5 -B20, Nm r [...”
- Characterization of Mutations That Affect the Nonoxidative Pentose Phosphate Pathway in Sinorhizobium meliloti
Hawkins, Journal of bacteriology 2018 - “...presence of erythritol, a mutant allele of mptB (SMc01627), which encodes part of the transporter necessary for erythritol uptake, was transduced into SRmD397...”
BL0189 sugar permease of ABC transporter system from Bifidobacterium longum NCC2705
28% identity, 90% coverage
alr2532 sugar ABC transport system, permease protein from Nostoc sp. PCC 7120
28% identity, 87% coverage
- Chemoheterotrophic growth of the Cyanobacterium Anabaena sp. strain PCC 7120 dependent on a functional cytochrome c oxidase
Stebegg, Journal of bacteriology 2012 - “...all1823, all1916, all4824, all5282, alr0738, alr0789, alr2532, alr2722, alr3705, alr4277, alr4781, alr5362, alr5367, and alr5368) are currently annotated...”
P73352 Lactose transport system permease protein LacF from Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa)
slr1202 lactose transport system permease protein; LacF from Synechocystis sp. PCC 6803
30% identity, 94% coverage
- Characterization of the binding protein-dependent cellobiose and cellotriose transport system of the cellulose degrader Streptomyces reticuli
Schlösser, Applied and environmental microbiology 1999 (secret) - A global transcriptional activator involved in the iron homeostasis in cyanobacteria
Liu, Science advances 2024 - “..., Slr0382, nickel transport protein Motif-1 sll1598 , MntC, Mn transporter MntC Others Sugar transport slr1202 , Slr1202, permease protein of sugar ABC transporter Motif-2, -3 slr1723 , Slr1723, permease protein of sugar ABC transporter Motif-1, -2 slr0044 , CmpD, bicarbonate transport system ATP-binding protein Motif-1,...”
- RNA-Seq analysis provides insights for understanding photoautotrophic polyhydroxyalkanoate production in recombinant Synechocystis Sp
Lau, PloS one 2014 - “...and chlorophyll metabolism slr1675 hydrogenase expression/formation protein, HypA 2.01 111.92 225.29 cellular protein modification process slr1202 lactose ABC transporter permease 1.96 16.49 32.23 transport sll1740 50S ribosomal protein L19 1.93 427.21 825.93 translation sll1538 beta-glucosidase 1.92 21.65 41.64 carbohydrate metabolism slr1205 ferredoxin component 1.92 214.39 412.13...”
- Design and characterization of molecular tools for a Synthetic Biology approach towards developing cyanobacterial biotechnology
Huang, Nucleic acids research 2010 - “...and hence IPTG, into the cells, but there are candidate genes such as slr1723 and slr1202 (permeases) ( 68 ) and sll1374 (putative sugar transporter) ( 69 ). The low induction problem caused by limited diffusion of IPTG has been previously recognized ( 70 ) and...”
blr1890 ABC transporter permease protein from Bradyrhizobium japonicum USDA 110
32% identity, 71% coverage
DJ458_RS02930 carbohydrate ABC transporter permease from Staphylococcus pseudintermedius
30% identity, 72% coverage
BAD_RS00810 carbohydrate ABC transporter permease from Bifidobacterium adolescentis ATCC 15703
30% identity, 89% coverage
- Combining of transcriptome and metabolome analyses for understanding the utilization and metabolic pathways of Xylo-oligosaccharide in Bifidobacterium adolescentis ATCC 15703
Yang, Food science & nutrition 2019 - “...Sugar ABC transporter permease 911.12 326.41 BAD_RS08280 1.46 msmF Sugar ABC transporter permease 1,353.65 491.14 BAD_RS00810 1.45 yurN Sugar ABC transporter permease 762.04 278.86 BAD_RS03705 1.35 ABC transporter permease 91.4 35.95 BAD_RS00990 1.33 ABC transporter substratebinding protein 34.99 13.91 BAD_RS03325 1.29 MJ1508 ABC transporter ATPbinding protein...”
- “...Compared to xylose treatment, genes including the sugar transporter permease protein (encoded by BAD_RS00815, BAD_RS08280, BAD_RS00810, BAD_RS08205, BAD_RS03705, BAD_RS02260, BAD_RS07410) and transporter ATPbinding protein (encoded by BAD_RS02265, BAD_RS00495, BAD_RS04090, BAD_RS08375) were upregulated (Table 3 ), the same situation occurs in metabolites, including Lthreonine (meta_58), cellobiose (meta_991),...”
Ava_0461 Binding-protein-dependent transport systems inner membrane component from Anabaena variabilis ATCC 29413
28% identity, 87% coverage
SM_b21104 ABC transporter for L-Fucose, permease component 1 from Sinorhizobium meliloti 1021
30% identity, 78% coverage
- mutant phenotype: Specific phenotypes on L-Fucose.
SPO3785 carbohydrate ABC transporter permease from Ruegeria pomeroyi DSS-3
30% identity, 95% coverage
alr0738 permease protein of sugar ABC transporter from Nostoc sp. PCC 7120
30% identity, 81% coverage
- Chemoheterotrophic growth of the Cyanobacterium Anabaena sp. strain PCC 7120 dependent on a functional cytochrome c oxidase
Stebegg, Journal of bacteriology 2012 - “...genes (all0261, all1027, all1823, all1916, all4824, all5282, alr0738, alr0789, alr2532, alr2722, alr3705, alr4277, alr4781, alr5362, alr5367, and alr5368) are...”
BAD_RS07410 carbohydrate ABC transporter permease from Bifidobacterium adolescentis ATCC 15703
29% identity, 86% coverage
- Combining of transcriptome and metabolome analyses for understanding the utilization and metabolic pathways of Xylo-oligosaccharide in Bifidobacterium adolescentis ATCC 15703
Yang, Food science & nutrition 2019 - “...permease 160.73 12.98 BAD_RS05940 3.51 MFS transporter 6.71 0.59 BAD_RS01050 3.47 Shikimate kinase 173.6 15.68 BAD_RS07410 3.27 ABC transporter permease 159.79 16.53 BAD_RS07415 3.23 ABC transporter, solutebinding protein 486.74 51.88 BAD_RS08735 3.18 RNA polymerase sigma factor 18.24 2.01 BAD_RS00260 3.01 hsp20/alpha crystallin family protein 13,180.79 1,634.87...”
- “...Linear FMPK value XOS Xylose BAD_RS07405 3.02 amyC Multiple sugarbinding transport system permease 105.08 12.98 BAD_RS07410 3.27 amyD ABC transporter permease 159.79 15.53 BAD_RS07415 2.80 mdxE ABC transporter, solutebinding protein 360.4 51.88 BAD_RS02255 3.00 yurO Sugar ABC transporter substratebinding protein 7,940.17 989.28 BAD_RS01495 2.69 TP_0034 ABC...”
ML1768 sugar transport integral membrane protein from Mycobacterium leprae TN
28% identity, 91% coverage
Tsac_1344 carbohydrate ABC transporter permease from Thermoanaerobacterium saccharolyticum JW/SL-YS485
28% identity, 88% coverage
Npun_R2793 binding-protein-dependent transport systems inner membrane component from Nostoc punctiforme
29% identity, 91% coverage
CD2549 putative sugar transporter, permease protein from Clostridium difficile 630
27% identity, 86% coverage
- A curated C. difficile strain 630 metabolic network: prediction of essential targets and inhibitors
Larocque, BMC systems biology 2014 - “...ribC 3 , CD0557 2 , CD1966 3 *, CD2256 2 *, CD2541 2 *, CD2549 2 * , CD3555 3 , CD3596 1 , pykF 1 (15.51%), CD0994 1 * (15.08%), serA 1 (15.08%), ackA 1 (14.74%), asnA 1 (5.76%) No B. subtilis homolog (8)...”
- “...that are upregulated during infection and predicted to be essential such as fabD, serA or CD2549, are of additional interest as they could not only affect growth, but also colonisation and pathogenesis processes [ 57 ] (Table 3 ). Detection of potential human cross-reactivity targets Sequence...”
RPA1396 possible multiple sugar transport system permease protein from Rhodopseudomonas palustris CGA009
30% identity, 84% coverage
RLO149_c015780 carbohydrate ABC transporter permease from Roseobacter litoralis Och 149
29% identity, 88% coverage
- Comparative genome analysis and genome-guided physiological analysis of Roseobacter litoralis
Kalhoefer, BMC genomics 2011 - “...chain dehydrogenase RLO149_c015760 RafA: alpha-galactosidase (EC 3.2.1.22) RLO149_c015770 putative galactoside ABC transporter inner membrane component RLO149_c015780 putative galactoside ABC transporter inner membrane component RLO149_c015790 putative extracellular galactoside-binding protein RLO149_c015800 HTH-type transcriptional regulator, IclR family RLO149_c015810 putative galactoside ABC transporter ATP-binding protein Cluster 2 RLO149_c021930 putative HTH-type...”
Pden_1089 binding-protein-dependent transport systems inner membrane component from Paracoccus denitrificans PD1222
30% identity, 74% coverage
MSMEG_5573 sugar ABC transporter permease protein from Mycobacterium smegmatis str. MC2 155
33% identity, 85% coverage
SCO2945 sugar transporter membrane protein from Streptomyces coelicolor A3(2)
28% identity, 89% coverage
TM0431 sugar ABC transporter, permease protein from Thermotoga maritima MSB8
30% identity, 87% coverage
H9Q64_10120 carbohydrate ABC transporter permease from Enterococcus faecalis
EF2233 ABC transporter, permease protein from Enterococcus faecalis V583
28% identity, 90% coverage
GGTC_SYNY3 / Q55472 Osmoprotective compounds uptake permease protein GgtC from Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa) (see paper)
TC 3.A.1.1.32 / Q55472 Membrane bound sugar transport protein, component of The glucosylglycerol uptake transporter (functions in osmoprotection and also transports sucrose and trehalose (Mikkat and Hagemann, 2000) (most similar to 3.A.1.1.8) from Synechocystis sp. (strain PCC 6803) (see paper)
slr0530 membrane bound sugar transport protein from Synechocystis sp. PCC 6803
26% identity, 86% coverage
- function: Part of the ABC transporter complex GgtABCD involved in the uptake of the osmoprotective compounds glucosylglycerol (GG), sucrose and trehalose (PubMed:11081796). Responsible for the translocation of the substrate across the membrane (Probable).
subunit: The complex is composed of two ATP-binding proteins (GgtA), two transmembrane proteins (GgtC and GgtD) and a solute-binding protein (GgtB).
disruption phenotype: Inactivation of the gene results in loss of the ability to take up glucosylglycerol and sucrose, as well as to accumulate exogenous trehalose. Insertion causes leakage of glucosylglycerol from the cells into the medium. - substrates: Glucosylglycerol
- Identification of the key functional genes in salt-stress tolerance of Cyanobacterium Phormidium tenue using in silico analysis
Shahbazi, 3 Biotech 2021 - “...protein, slr1384 hypothetical protein, slr0613 ggtC, slr0530 probable RNA methyltransferase, sll1967 ribF, slr1882 hypothetical protein, slr1827 ycf85, slr0251...”
- Integrative analysis of the salt stress response in cyanobacteria
Klähn, Biology direct 2021 - “...Among the 19 salt-induced genes, whose proteins were not identified in our study, only the slr0530 gene product as component of the GG transporter is functionally related to known processes in salt acclimation. The good correlation of transcriptomic and proteomic changes extends to the alterations on...”
- RNA-seq Profiling Reveals Novel Target Genes of LexA in the Cyanobacterium Synechocystis sp. PCC 6803
Kizawa, Frontiers in microbiology 2016 - “...215.11 5.97 slr0529 ggtB Glucosylglycerol transport system substrate-binding protein 17.28 79.09 4.58 18.76 76.80 4.09 slr0530 ggtC Glucosylglycerol transport system permease protein 21.55 102.21 4.74 23.34 88.37 3.79 HYDROGENASE sll1220 hoxE Diaphorase subunit of the bidirectional hydrogenase 100.28 48.94 0.49 62.85 32.54 0.52 sll1221 hoxF Diaphorase...”
- Computational prediction of the osmoregulation network in Synechococcus sp. WH8102
Mao, BMC genomics 2010 - “...SpsA Sucrose synthetase slr1312 SpeA Arginine synthetase slr0662 SpeA slr0747 GgtA Glucosylglycerol/trehalose/sucrose slr0529 GgtB transporter slr0530 GgtC slr0531 GgtD sll1546 GgpS Glucosylglycerol synthetases slr0746 GgpP sll0306 RpoD RNA polymerase, Sigma 70 (sigma D) factor A. halo has three genes encoding a Na + /H + antiporter...”
- “...GgpS SYNW1281 SYNW1279-1286 0.99 PCC6803 slr0746 GgpP SYNW0860 PCC6803 slr0747 GgtA SYNW1285 SYNW1279-1286 0.99 PCC6803 slr0530 GgtC SYNW1283 SYNW1279-1286 0.99 PCC6803 slr0531 GgtD SYNW1284 SYNW1279-1286 0.99 PCC6803 ABX75857 GpgS SYNW2436 P.marina ABX75858 GpgP SYNW2434 P.marina slr0662 SpeA SYNW2359 0.99 PCC6803 sll0045 Sps SYNW2520 0.69 PCC6803 b0855...”
- A novel Sinorhizobium meliloti operon encodes an alpha-glucosidase and a periplasmic-binding-protein-dependent transport system for alpha-glucosides
Willis, Journal of bacteriology 1999 - “...oligo-1,6-glucosidase (65) Synechocystis Slr0531 (35, 37) Synechocystis Slr0530 (35, 37) Synechocystis Slr0529 (35, 37) Escherichia coli RafR (4) Pseudomonas...”
- “...also implies that the uncharacterized Synechocystis proteins Slr0529, Slr0530, and Slr0531 are involved in sugar transport. Sucrose and trehalose are known to...”
TM0596 sugar ABC transporter, permease protein from Thermotoga maritima MSB8
31% identity, 52% coverage
BAB2_0548 Vacuolar H+-transporting two-sector ATPase, C subunit:Binding-protein-dependent transport systems inner membrane component:Ar... from Brucella melitensis biovar Abortus 2308
30% identity, 85% coverage
- Endoribonuclease YbeY Is Linked to Proper Cellular Morphology and Virulence in Brucella abortus
Budnick, Journal of bacteriology 2018 - “...an ABC transporter periplasmic binding protein), and bab2_0548 (encoding an ABC transporter permease), were shown previously to be differentially expressed in...”
- “...(encoding an ABC transporter periplasmic binding protein), bab2_0548 (encoding an ABC transporter permease), bab2_0830 (encoding an ABC transporter periplasmic...”
- Molecular control of gene expression by Brucella BaaR, an IclR-type transcriptional repressor
Herrou, The Journal of biological chemistry 2018 - “...BetI TetR transcriptional regulator; bab1_0914, DUF1127; bab2_0548, ABC transmembrane transporter). B, genomic organization of the bab2_0213- bab2_0217 operon....”
- “...TetR transcriptional regulator), bab1_0914 (DUF1127), and bab2_0548 (ABC transmembrane transporter) also showed significant differential regulation in our data...”
- Evaluation of the effects of erythritol on gene expression in Brucella abortus
Rodríguez, PloS one 2012 - “...BAB2_0491 0.55 0.47 Extracellular solute-binding protein COG1653G BAB2_0547 0.61 0.48 Solute-binding family 1 protein COG1653G BAB2_0548 0.67 0.34 Vacuolar H+-transporting ATPase COG1175G BAB2_0712 0.40 Branched chain ketoacid dehydrogenase COG1249C BAB2_0713 0.57 Branched chain ketoacid dehydrogenase COG0508C BAB2_0714 0.53 0.44 Branched chain ketoacid dehydrogenase COG0022C BAB2_0715 0.46...”
- “...subsequent increased growth. On the other hand, we found 3 down-regulated genes, BAB2_0491, BAB2_0547 and BAB2_0548, ( Table S2 ), that are putatively involved in sugar transport systems. This could indicate that erythritol up-regulates its own transport while down-regulates the transport of other sugars. When Brucella...”
BMEII0591 SUGAR TRANSPORT SYSTEM PERMEASE PROTEIN from Brucella melitensis 16M
30% identity, 90% coverage
- Transcriptomic Analysis of the Brucella melitensis Rev.1 Vaccine Strain in an Acidic Environment: Insights Into Virulence Attenuation
Salmon-Divon, Frontiers in microbiology 2019 - “...Magnesium-translocating P-type ATPase Upregulation BMEII0077 Isochorismate synthase Upregulation BMEII0361 Sugar ABC transporter ATP-binding protein Upregulation BMEII0591 Sugar ABC transporter permease Upregulation BMEII0761 Thiol reductant ABC exporter subunit CydC Downregulation BMEII0762 Thiol reductant ABC exporter subunit CydD Downregulation BMEII0923 ABC transporter substrate-binding protein Upregulation BMEII0931 Class Ib...”
- “...from the RNA-seq experiment, we conducted a real-time qPCR analysis of five selected genes (BMEII0027, BMEII0591, BMEI1980, BMEII1116, and BMEI1040), from both strains (16M and Rev.1), grown under either low- or normal-pH conditions. The mRNA levels of all genes obtained by the RT-qPCR were in high...”
- Main functions and taxonomic distribution of virulence genes in Brucella melitensis 16 M
Brambila-Tapia, PloS one 2014 - “...BMEI2031 ptsH Phosphocarrier protein HPr G 273 [8] BMEII0485 galcD D-galactarate dehydratase G 185 [7] BMEII0591 BMEII0591 Sugar transport system permease G 119 [7] BMEII0624 ugpA SN-glycerol-3-phosphate transport system permease G 136 [7] BMEII0899 BMEII0899 Phosphomannomutase G 32 [8] BMEII0935 BMEII0935 Nickel resistance protein G 184...”
- Erythritol triggers expression of virulence traits in Brucella melitensis
Petersen, Microbes and infection 2013 - “...Ribose 5-phosphate isomerase 2.51 0.95 BMEII0425 Triosephosphate isomerase 1.97 0.61 BMEII0590 Sugar-binding protein 20.38 1.00 BMEII0591 Sugar transport system permease protein 6.93 1.00 BMEII0592 Sugar transport system permease protein 7.56 1.00 BMEII0593 Glucose ABC transporter ATPase 4.11 1.00 Other BMEI0095 Succinoglycan biosynthesis regulator 2.39 0.95 BMEI0102...”
- ATP-Binding Cassette Systems of Brucella
Jenner, Comparative and functional genomics 2009 - “...or polyol import BP BMEII0590 BruAb20537 BRA0693 BOV_A0648 BCAN_B0691 OSP Oligosaccharide or polyol import IM BMEII0591 BruAb20538 BRA0691 BOV_A0647 BCAN_B0690 OSP Oligosaccharide or polyol import IM BMEII0592 BruAb20539 BRA0692 BOV_A0646 BCAN_B0689 OSP Oligosaccharide or polyol import ABC BMEII0593 BruAb20540 BRA0690 BOV_A0645 BCAN_B0688 79 OSP SN-glycerol-3-phosphate import...”
- Attenuated signature-tagged mutagenesis mutants of Brucella melitensis identified during the acute phase of infection in mice
Lestrate, Infection and immunity 2003 - “...protein Hypothetical protein BMEI0359 BMEI1069 BMEII0591 BMEII0624 BMEI0433 BMEI0624 BMEI0705 BMEI1301 BMEII0485 BMEII0823 BMEI0357 BMEI1336 BMEII1066...”
TC 3.A.1.1.4 / P29823 LacF, component of Lactose porter from Agrobacterium radiobacter (see paper)
29% identity, 91% coverage
BOV_A0647 putative sugar ABC transporter, permease protein from Brucella ovis ATCC 25840
BRA0692 sugar ABC transporter, permease protein, putative from Brucella suis 1330
BCAN_B0690 Probable starch degradation products transport system permease protein amyD from Brucella canis ATCC 23365
30% identity, 85% coverage
- ATP-Binding Cassette Systems of Brucella
Jenner, Comparative and functional genomics 2009 - “...BP BMEII0590 BruAb20537 BRA0693 BOV_A0648 BCAN_B0691 OSP Oligosaccharide or polyol import IM BMEII0591 BruAb20538 BRA0691 BOV_A0647 BCAN_B0690 OSP Oligosaccharide or polyol import IM BMEII0592 BruAb20539 BRA0692 BOV_A0646 BCAN_B0689 OSP Oligosaccharide or polyol import ABC BMEII0593 BruAb20540 BRA0690 BOV_A0645 BCAN_B0688 79 OSP SN-glycerol-3-phosphate import ABC BMEII0621, ugpC...”
- ATP-Binding Cassette Systems of Brucella
Jenner, Comparative and functional genomics 2009 - “...import IM BMEII0591 BruAb20538 BRA0691 BOV_A0647 BCAN_B0690 OSP Oligosaccharide or polyol import IM BMEII0592 BruAb20539 BRA0692 BOV_A0646 BCAN_B0689 OSP Oligosaccharide or polyol import ABC BMEII0593 BruAb20540 BRA0690 BOV_A0645 BCAN_B0688 79 OSP SN-glycerol-3-phosphate import ABC BMEII0621, ugpC BruAb20568, ugpC BRA0658, ugpC BOV_A0620 BCAN_B0658 OSP SN-glycerol-3-phosphate import IM...”
- ATP-Binding Cassette Systems of Brucella
Jenner, Comparative and functional genomics 2009 - “...BMEII0590 BruAb20537 BRA0693 BOV_A0648 BCAN_B0691 OSP Oligosaccharide or polyol import IM BMEII0591 BruAb20538 BRA0691 BOV_A0647 BCAN_B0690 OSP Oligosaccharide or polyol import IM BMEII0592 BruAb20539 BRA0692 BOV_A0646 BCAN_B0689 OSP Oligosaccharide or polyol import ABC BMEII0593 BruAb20540 BRA0690 BOV_A0645 BCAN_B0688 79 OSP SN-glycerol-3-phosphate import ABC BMEII0621, ugpC BruAb20568,...”
NH13_08155 carbohydrate ABC transporter permease from Lactobacillus acidophilus
26% identity, 87% coverage
- Draft Genome Sequence of the Probiotic Strain Lactobacillus acidophilus ATCC 4356
Palomino, Genome announcements 2015 - “...components (NH13_02050), as well as the N -acetyl- d -glucosamine ABC transport system, permease protein (NH13_08155). Mechanisms of the enzymes degrading N -acetylglucosamine ( 15 ) are predicted: NagB, GlcN6P deaminase (NH13_09645) and NagA, GlcNAc6P deacetylase (NH13_00815). A transcriptional regulator of N -acetylglucosamine utilization (NH13_02010) from...”
Ccel_2111 binding-protein-dependent transport systems inner membrane component from Clostridium cellulolyticum H10
Ccel_2111 carbohydrate ABC transporter permease from Ruminiclostridium cellulolyticum H10
25% identity, 88% coverage
- Internal Transcription Terminators Control Stoichiometry of ABC Transporters in Cellulolytic Clostridia
Wu, Microbiology spectrum 2022 - “...cluster harbors an SBP gene (Ccel_2112) at the 5 end, followed by two TMD genes (Ccel_2111 and Ccel_2110), and has a 106-bp long intergenic region between Ccel_2112 and Ccel_2111. Ccel_2112, encoding SBPs, was transcribed at significantly higher levels than its downstream genes ( Fig.3A ). Northern...”
- “...an operon, and the transcripts of Ccel_2112-2110 were terminated at the 3 ends of Ccel_2112, Ccel_2111, and Ccel_2110. Subsequently, three stem-loop structures were predicted at the 3 ends of Ccel_2112, Ccel_2111, and Ccel_2110 ( Fig.3D ), suggesting that they potentially terminate the transcription of the cluster...”
BBMN68_1169 carbohydrate ABC transporter permease from Bifidobacterium longum subsp. longum BBMN68
27% identity, 89% coverage
BL105A_0202, BLLJ_0209 carbohydrate ABC transporter permease from Bifidobacterium longum
27% identity, 89% coverage
MSMEG_4466 ABC transporter, permease protein UspA from Mycobacterium smegmatis str. MC2 155
29% identity, 84% coverage
- A Mycobacterial Systems Resource for the Research Community
Judd, mBio 2021 - “...strain ( TableS1 ). The remaining 14 genes encode full-length proteins (with the exception of MSMEG_4466 , which uses an initiation codon 15 amino acids downstream of the misannotated start). This provides a cautionary note, indicating there are distinct genetic lineages among the laboratory strains of...”
TRQ7_RS03395 carbohydrate ABC transporter permease from Thermotoga sp. RQ7
29% identity, 92% coverage
- Adapted laboratory evolution of Thermotoga sp. strain RQ7 under carbon starvation
Gautam, BMC research notes 2022 - “...Silent: H107 ABC transporters 409,563 TRQ7_RS02130 ABC transporter substrate-binding protein Transition: AG Missense: Q545R 668132 TRQ7_RS03395 Sugar ABC transporter permease Transition: CT Missense: A283V 1046451 TRQ7_RS05215 Sugar ABC transporter ATP-binding protein Transition: CT Missense: A406V 1,049,370 TRQ7_RS05225 Sugar ABC transporter substrate-binding protein Transition: CT Missense: P115S...”
Saci_1164 conserved Archaeal transport protein from Sulfolobus acidocaldarius DSM 639
26% identity, 90% coverage
- Impact of nutrient excess on physiology and metabolism of <i>Sulfolobus acidocaldarius</i>
Sedlmayr, Frontiers in microbiology 2024 - “...kinase 2.4 1.3 saci_1162 Membrane-bound alpha-amylase 2.3 1.6 saci_1163 Sugar transport system permease 1.3 NA saci_1164 Conserved transport protein 1.5 NA saci_1165 Sugar-binding periplasmic protein 1.7 NA saci_1166 ABC transporter ATPase 1.4 NA saci_1167 Conserved CBS domain protein 1.7 1.2 saci_1760 Conserved membrane protein 2.1 1.2...”
- Investigation of the malE promoter and MalR, a positive regulator of the maltose regulon, for an improved expression system in Sulfolobus acidocaldarius
Wagner, Applied and environmental microbiology 2014 - “...(Saci_1162) (27), two permeases, MalF and MalG (Saci_1163 and Saci_1164), and a sugar binding protein, MalE (Saci_1165) (Fig. 1). This operon is flanked by an...”
- Identification and characterization of MalA in the maltose/maltodextrin operon of Sulfolobus acidocaldarius DSM639
Choi, Journal of bacteriology 2013 - “...encoding permeases MalG and MalF (Saci_1163 and Saci_1164, respectively) and the maltose-binding protein MalE (Saci_1165), suggesting a potential role for this...”
- Inducible and constitutive promoters for genetic systems in Sulfolobus acidocaldarius
Berkner, Extremophiles : life under extreme conditions 2010 - “...to use sugars as substrate in S. acidocaldarius consists of the genes saci_1165 (binding protein), saci_1164 and saci_1163 (permease). Saci_1165 is annotated as maltodextrin-binding protein (Chen et al. 2005 ). Therefore, we tested if the promoter of saci_1165 ( mal promoter) was inducible upon maltose addition...”
TC 3.A.1.1.50 / Q5SLB6 Sugar ABC transporter, permease protein, component of Probable glycerophosphocholine (GPC) uptake porter (Chandravanshi et al. 2016). The system may include a receptor and three membrane proteins (of 378 aas and 6 TMSs, 299 aas and 7 TMSs, and 113 aas and 3 TMSs (?). The ATPase has not been identified from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
30% identity, 70% coverage
- substrates: glycerophosphocholine
spr1619 ABC transporter membrane-spanning permease - sugar transporter from Streptococcus pneumoniae R6
27% identity, 77% coverage
SPD_1584 ABC transporter, permease protein from Streptococcus pneumoniae D39
27% identity, 77% coverage
C289_0466 carbohydrate ABC transporter permease from Anoxybacillus ayderensis
28% identity, 56% coverage
- A high molecular-mass Anoxybacillus sp. SK3-4 amylopullulanase: characterization and its relationship in carbohydrate utilization
Kahar, International journal of molecular sciences 2013 - “...pullulanase (C289_2260), glycosidase (C289_2139), and oligo-1,6-glucosidase (C289_0857, C289_1909, and C289_2139). Several putative sugar transporters (C289_0465, C289_0466, C289_0467, C289_0603, C289_0763, C289_0764, C289_0765, C289_0778, C289_0779, C289_0780, C289_1015, C289_1174, C289_1392, C289_1394, C289_1910, C289_1911, and C289_1912) were also found in the Blast2GO annotation. The draft genome was submitted to the...”
BLGT_09100 carbohydrate ABC transporter permease from Bifidobacterium longum subsp. longum GT15
27% identity, 95% coverage
AT5A_24050 carbohydrate ABC transporter permease from Agrobacterium tumefaciens 5A
28% identity, 87% coverage
- Introducing the ArsR-Regulated Arsenic Stimulon
Rawle, Frontiers in microbiology 2021 - “...ABC transporter nucleotide ATPase 2.0 2.6 2.2 AT5A_24045 Sugar ABC transporter permease 2.0 2.9 2.1 AT5A_24050 Sugar ABC transporter permease 2.40 Gray highlighted data identifies genes uniquely affected in the respective arsR mutant and presumed to be controlled directly or indirectly by only that ArsR. Under...”
BCAL3040 ABC transporter, membrane permease from Burkholderia cenocepacia J2315
28% identity, 87% coverage
- Various Evolutionary Trajectories Lead to Loss of the Tobramycin-Potentiating Activity of the Quorum-Sensing Inhibitor Baicalin Hydrate in Burkholderia cenocepacia Biofilms
Sass, Antimicrobial agents and chemotherapy 2019 - “...CDS (2895340 to 2895341 GC to TT, 81 R724C) BCAL3040 ABC-type sugar transport system, permease SNP in CDS (3332415 A to G, F51L) 100 component BCAM0821...”
- “...encoding the permease of a glucose/mannose ABC transporter (BCAL3040) was observed, likely affecting the uptake of certain carbohydrates. None of the mutations...”
- Burkholderia cenocepacia differential gene expression during host-pathogen interactions and adaptation to the host environment
O'Grady, Frontiers in cellular and infection microbiology 2011 - “...BCAL3038 ABC transporter ATP-binding component, carbohydrate ABC transporter 1.6 BCAL3039 ABC transporter, membrane permease 1.5 BCAL3040 ABC transporter, membrane permease 1.7 BCAL3041 MalE, maltose-binding protein 2.1 BCAL3364 Putative gluconokinase 1.7 BCAM0094 Xylulose kinase 1.7 BCAM1330 Cellulose polysaccharide export protein 1.7 BCAM1333 Cellulose exopolysaccharide acyltransferase 1.6 BCAM1390...”
- “...lipoproteins carrier 1.53 BCAL3038 ABC transporter ATP-binding component 1.61 BCAL3039 ABC transporter, membrane permease 1.54 BCAL3040 ABC transporter, membrane permease 1.71 BCAL3041 Maltose-binding protein 2.09 BCAL3163 Putative nucleotidyltransferase 1.68 BCAL3203 Putative periplasmic TolB protein 1.64 BCAL3204 Putative OmpA family lipoprotein 1.68 BCAL3205 Putative exported protein 1.62...”
Dshi_1651 glucose/maltose/trehalose/sucrose ABC transporter, permease component 1 from Dinoroseobacter shibae DFL-12
25% identity, 92% coverage
- mutant phenotype: Related to alpha-glucoside transporter component aglF. Specifically important for utilization of D-glucose, D-maltose, D-trehalose, and sucrose.
IYO_006370 carbohydrate ABC transporter permease from Pseudomonas syringae pv. actinidiae ICMP 18884
PSPTO_1293 glucose ABC transporter, permease protein, putative from Pseudomonas syringae pv. tomato str. DC3000
30% identity, 87% coverage
- Transposon insertion libraries for the characterization of mutants from the kiwifruit pathogen Pseudomonas syringae pv. actinidiae
Mesarich, PloS one 2017 - “...plating was carried out in triplicate. The nine remaining genes ( IYO_001755 , IYO_006345 , IYO_006370 , IYO_007710 , IYO_008365 , IYO_012780 , IYO_025885 , IYO_026305 and IYO_027710 ) were disrupted only once in the set of putative complete or partial auxotrophic mutants analyzed ( S2...”
- Data-Independent Acquisition Proteomics Unravels the Effects of Iron Ions on Coronatine Synthesis in Pseudomonas syringae pv. tomato DC3000
He, Frontiers in microbiology 2020 - “...for amino acid uptake (PSPTO_4887, PSPTO_4173, PSPTO_4919, PSPTO_1258, PSPTO_1256, and PSPTO_1255), glucose ABC transporter (PSPTO_1294, PSPTO_1293, and gltK), ribose ABC transporters (rbsA-1), iron ABC transporters (PSPTO_5562 and PSPTO_5561), peptide transporters (PSPTO_4562, PSPTO_4559, dppC, PSPTO_4558, and PSPTO_4564), a mannitol ABC transporter (PSPTO_2705), dipeptide ABC transporters (PSPTO_4562, PSPTO_4559,...”
MELD_BACSU / O34706 Melibiose/raffinose/stachyose import permease protein MelD from Bacillus subtilis (strain 168) (see paper)
BSU30280 carbohydrate ABC transporter (permease) from Bacillus subtilis subsp. subtilis str. 168
26% identity, 90% coverage
- function: Part of the ABC transporter complex MelEDC-MsmX involved in melibiose, raffinose and stachyose import. Probably responsible for the translocation of the substrate across the membrane.
subunit: The complex is composed of two ATP-binding proteins (MsmX), two transmembrane proteins (MelC and MelD) and a solute-binding protein (MelE).
disruption phenotype: Deletion of the gene abolishes induction in the presence of melibiose and raffinose. - rocF affects the production of tetramethylpyrazine in fermented soybeans with Bacillus subtilis BJ3-2
Liu, BMC biotechnology 2022 - “...Up BSU36550 417.195 1556.086 1.9 5.17E-05 3.63E-03 Up BSU19050 7.277 27.08 1.88 1.08E-03 3.68E-02 Up BSU30280 10.263 35.571 1.78 4.72E-04 1.96E-02 Up BSU30290 8.444 28.629 1.75 9.44E-04 3.34E-02 Up BSU38080 223.922 747.383 1.74 1.76E-04 9.59E-03 Up BSU31060 17.602 58.817 1.73 2.31E-04 1.16E-02 Up BSU25150 9.698 32.51...”
- Regulon of the N-acetylglucosamine utilization regulator NagR in Bacillus subtilis
Bertram, Journal of bacteriology 2011 - “...J. BACTERIOL. yvfM, ganQ amyD dhaS yjdB BSU34140 BSU30280 BSU19310 BSU11990 a --, cis-acting element, trans-acting regulator, pathway, or regulon unknown. Genes...”
CAC0427 Glycerol-3-phosphate ABC-transporter, permease component from Clostridium acetobutylicum ATCC 824
25% identity, 90% coverage
- A proteomic and transcriptional view of acidogenic and solventogenic steady-state cells of Clostridium acetobutylicum in a chemostat culture
Janssen, Applied microbiology and biotechnology 2010 - “...7.3 5.3 4.4 2.3 S CAC0412 TPR-repeat-containing protein 2.0 1.7 5.5 3.9 3.3 1.8 R CAC0427 Glycerol-3-phosphate ABC transporter, permease component 3.1 3.1 5.7 2.9 3.7 1.3 G CAC0428 Sugar permease 4.2 2.7 11.2 3.5 5.4 3.9 G CAC0429 Glycerol-3-phosphate ABC transporter, periplasmic component 4.6 3.3...”
- “...putative ATP binding protein involved in sugar transport ( msmX , CAC3237) and the genes cac0427 , cac0428 , and cac0429 of a glycerol-3-phosphate ABC transporter system which are organized in a common operon together with glycerophosphoryl diester phosphodiesterase ( cac0430 ; Karp et al. 2005...”
HVO_B0229 ABC-type transport system permease protein (probable substrate sugar) from Haloferax volcanii DS2
29% identity, 85% coverage
TC 3.A.1.1.20 / Q7WWQ9 Transmembrane permease MsmF, component of The fructooligosaccharide porter, MsmEFGK from Lactobacillus acidophilus (see 2 papers)
msmF / GI|33149339 transmembrane permease MsmF from Lactobacillus acidophilus (see paper)
27% identity, 78% coverage
- substrates: Fructooligosaccharides
APY09_06050 ABC transporter permease subunit from Schaalia odontolytica
35% identity, 38% coverage
TC 3.A.1.1.15 / Q97ZC2 TreT, component of Trehalose porter from Sulfolobus solfataricus (see paper)
SSO1000 Maltose transport inner membrane protein from Sulfolobus solfataricus P2
32% identity, 59% coverage
BAD_1586 ABC transporter_ membrane spanning protein[sugar] from Bifidobacterium adolescentis ATCC 15703
29% identity, 90% coverage
- Metagenomic identification, purification and characterisation of the Bifidobacterium adolescentis BgaC β-galactosidase
Mulualem, Applied microbiology and biotechnology 2021 - “...LacI family transcriptional regulator (BAD_1584), carbohydrate ABC transporter substrate-binding protein (BAD_1585), sugar ABC transporter permease (BAD_1586), and carbohydrate ABC transporter permease (BAD_1587). The numbers at the start and end of each clone show location of the nucleotide sequences on the ATCC15703 genome Through bioinformatic analysis, BAD_1582...”
- “...). Downstream are genes encoding an ABC transporter substrate-binding protein (BAD_1585), sugar ABC transporter permease (BAD_1586) and carbohydrate ABC transporter permease (BAD_1587) which together form a complex to transport sugars (possibly lactose and other oligosaccharides) into the cell. In addition, the genome of B. adolescentis encodes...”
B4602_RS00885 carbohydrate ABC transporter permease from Staphylococcus aureus
28% identity, 67% coverage
SAOUHSC_00177 maltose ABC transporter, permease protein, putative from Staphylococcus aureus subsp. aureus NCTC 8325
SAUSA300_0210 maltose ABC transporter, permease protein from Staphylococcus aureus subsp. aureus USA300_FPR3757
NWMN_0153 hypothetical protein from Staphylococcus aureus subsp. aureus str. Newman
SACOL0194 maltose ABC transporter, permease protein from Staphylococcus aureus subsp. aureus COL
28% identity, 67% coverage
- Comparative Analysis of Virulence and Toxin Expression of Vancomycin-Intermediate and Vancomycin-Sensitive Staphylococcus aureus Strains
Jin, Frontiers in microbiology 2020 - “...SAOUHSC_00300 2.4787 1.03 2.09E-39 1.04E-38 Lipase SAOUHSC_02706 2.0555 6.25 2.26E-10 4.59E-10 Immunoglobulin G-binding protein Sbi SAOUHSC_00177 6.0315 ND 0 0 Maltose ABC transporter permease Hypothetical protein SAOUHSC_00179 6.4487 ND 0 0 Hypothetical protein SAOUHSC_00180 6.1303 0.2.98 0 0 Hypothetical protein SAOUHSC_00208 7.054 ND 1.13E-36 4.73E-36 Hypothetical...”
- Genomic and Long-Term Transcriptomic Imprints Related to the Daptomycin Mechanism of Action Occurring in Daptomycin- and Methicillin-Resistant Staphylococcus aureus Under Daptomycin Exposure
Cafiso, Frontiers in microbiology 2020 - “...only found in SAOUHSC_01387 inorganic phosphate transmembrane transporter. Results from carbohydrate transporters showed under-expression in SAOUHSC_00177 maltose ABC permease, in the SAOUHSC_02400 putative mannitol-specific PTS component, and in the SAOUHSC_00158 N -acetylmuramic acid transporter belonging to the phosphotransferase system. Cell adhesion Under-expression was shown in the...”
- Human Urine Alters Methicillin-Resistant Staphylococcus aureus Virulence and Transcriptome
Paudel, Applied and environmental microbiology 2021 (secret) - Inactivation of the Ecs ABC transporter of Staphylococcus aureus attenuates virulence by altering composition and function of bacterial wall
Jonsson, PloS one 2010 - “...cation/H + antiporter subunit D 1.9 NWMN_0048 drug transporter 2.0 NWMN_0136 PTS system component 2.7 NWMN_0153 maltose ABC transporter permease protein 2.7 NWMN_0154 maltose ABC transporter permease protein 2.5 NWMN_0199 PTS system IIA component 0.5 NWMN_0211 ABC transporter ATP-binding protein 1.9 NWMN_0343 ABC transporter ATP-binding protein...”
- In vitro and in vivo models of Staphylococcus aureus endophthalmitis implicate specific nutrients in ocular infection
Sadaka, PloS one 2014 - “...(1.5) 6.5 (1.6) SACOL0193 Maltose ABC transporter, maltose-bindingprotein, putative 14.4 (1.3) 3.4 (1.2) 4.2 (1.4) SACOL0194 Maltose ABC transporter permease protein 11.1 (1.5) 3.3 (1.4) 3.7 (1.4) SACOL0195 Maltose ABC transporter permease protein 13.9 (1.5) 3.7 (1.4) 3.4 (1.5) SACOL0196 Oxidoreductase, Gfo/Idh/MocA family 12.6 (1.5) 3.3...”
- Staphylococcus aureus gene expression in a rat model of infective endocarditis
Hanses, Genome medicine 2014 - “...lantibiotic ABC transporter protein malE SACOL0193 ns ns 3.1 2.5 maltose ABC transporter, maltose-binding malF SACOL0194 7.4 3.9 6.0 3.5 maltose ABC transporter, permease protein malK SACOL0192 14.7 14.7 6.2 6.8 maltose ABC transporter, ATP-binding protein opuD SACOL2176 2.0 2.4 ns ns osmoprotectant transporter, BCCT family...”
GRD61_RS02140 carbohydrate ABC transporter permease from Clavibacter michiganensis subsp. michiganensis
28% identity, 93% coverage
SA0208 hypothetical protein from Staphylococcus aureus subsp. aureus N315
28% identity, 67% coverage
SSO1170 Sugar transport protein, hypothetical from Sulfolobus solfataricus P2
27% identity, 91% coverage
SCO6086 transport system integral membrane protein from Streptomyces coelicolor A3(2)
30% identity, 100% coverage
MT2901 sugar ABC transporter, permease protein from Mycobacterium tuberculosis CDC1551
Rv2835c PROBABLE Sn-GLYCEROL-3-PHOSPHATE TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER UGPA from Mycobacterium tuberculosis H37Rv
31% identity, 88% coverage
- Transcriptional Profiling of Mycobacterium tuberculosis Exposed to In Vitro Lysosomal Stress
Lin, Infection and immunity 2016 - “...MT2097 MT2100 MT2101 MT2334 MT2339 MT2469 MT2471 MT2598 MT2901 Rv1607 Rv1877 Rv1922 Rv1946c Rv1964 Rv1979c Rv1986 Rv2037c Rv2040c Rv2041c Rv2273 Rv2281 Rv2398c...”
- Identification of outer membrane proteins of Mycobacterium tuberculosis
Song, Tuberculosis (Edinburgh, Scotland) 2008 - “...proteins such as the sugar permease UgpA (Rv2835c, MT2901), the efflux protein EfpA (Rv2846c, MT2912) and the ammonium transporter AmtB (Rv2920c, MT2988) and...”
- Microsatellite polymorphism across the M. tuberculosis and M. bovis genomes: implications on genome evolution and plasticity
Sreenu, BMC genomics 2006 - “...family protein Rv2566 (1140) MT2642 (1156) Mb2595 (533), Mb2596 (597) T4 3 ugpA *Rv2835c (303) MT2901 (303) Mb2859c (180), Mb2860c (123) C2 3 fadE22 *Rv3061c (721) MT3147 (721) Mb3087c (600), Mb3088c (114) C4 3 mesT *Rv3176c (318) MT3265 (339) Mb3201c (105), Mb3202c (208) C4 3 Cyp142...”
- ATP-binding cassette (ABC) import systems of Mycobacterium tuberculosis: target for drug and vaccine development
Soni, Emerging microbes & infections 2020 - “...Rv0073 Experimentally not characterized. Sugar importers Glycerophosphocholine importer (UgpABCE /Rv2832c-Rv2835c) SBP: UgpB (Rv2833c) TMD: UgpA (Rv2835c) and UgpE (Rv2834c) NBD: UgpC (Rv2832c) (two copies) UgpB is a substrate of the twin-arginine translocation (Tat) pathway [ 39 ] Import glycerophosphocholine instead of sn-glycerol-3-phosphate and maltose [ 39...”
- Regulation of the CRISPR-Associated Genes by Rv2837c (CnpB) via an Orn-Like Activity in Tuberculosis Complex Mycobacteria
Zhang, Journal of bacteriology 2018 - “...2018 by University of California, Berkeley Rv1955 Rv2835c Rv3862c Rv2450c Rv2816c Rv0341 Rv2836c Rv2817c Mobile element protein Isoniazid inducible protein IniA...”
- Transcriptional Profiling of Mycobacterium tuberculosis Exposed to In Vitro Lysosomal Stress
Lin, Infection and immunity 2016 - “...Rv2040c Rv2041c Rv2273 Rv2281 Rv2398c Rv2400c Rv2522c Rv2835c MT3080 MT3951 Rv3000 Rv3843c MT0691 MT0699 MT1338 MT1463 MT1589 MT2042 MT2247 MT2488 MT2535...”
- From Corynebacterium glutamicum to Mycobacterium tuberculosis--towards transfers of gene regulatory networks and integrated data analyses with MycoRegNet
Krawczyk, Nucleic acids research 2009 - “...( glnA1 ) Rv2832c ( ugpC ), Rv2833c ( ugpB ), Rv2834c ( ugpE ), Rv2835c ( ugpA ), Rv2918c ( glnD ) Rv2919c ( glnB ), Rv2920c ( amt ), Rv3859c ( gltB ) SOS and stress response Rv0867c ( rpfA ), Rv3048c ( nrdF2...”
- “...( phoH2 ) Rv2832c ( ugpC ), Rv2833c ( ugpB ), Rv2834c ( ugpE ), Rv2835c ( ugpA ) Rv0827c Macroelement and metal homeostasis Rv0827c (-) Rv1994c Macroelement and metal homeostasis Rv1994c (-) IdeR Carbohydrate metabolism Rv0247c (-), Rv3318 ( sdhA ) Macroelement and metal homeostasis...”
- Identification of outer membrane proteins of Mycobacterium tuberculosis
Song, Tuberculosis (Edinburgh, Scotland) 2008 - “...membrane proteins such as the sugar permease UgpA (Rv2835c, MT2901), the efflux protein EfpA (Rv2846c, MT2912) and the ammonium transporter AmtB (Rv2920c,...”
TC 3.A.1.1.22 / Q9X0T0 MalF1; aka Maltose ABC transporter, permease protein, component of The maltose, maltotriose, mannotetraose (MalE1)/maltose, maltotriose, trehalose (MalE2) porter (Nanavati et al., 2005). For MalG1 (823aas) and MalG2 (833aas), the C-terminal transmembrane domain with 6 putative TMSs is preceded by a single N-terminal TMS and a large (600 residue) hydrophilic region showing sequence similarity to MLP1 and 2 (9.A.14; e-12 & e-7) as well as other proteins from Thermotoga maritima (see paper)
TM1203 maltose ABC transporter, permease protein from Thermotoga maritima MSB8
32% identity, 44% coverage
- substrates: Maltose, Maltotetraose, Maltotriose, Trehalose
- Evolution of mal ABC transporter operons in the Thermococcales and Thermotogales
Noll, BMC evolutionary biology 2008 - “...TM1195 TM0810 TM1193 TM1200 TM1200 TM1200 TM1200 TM1201 TM1201 TM1201 TM1201 TM1202 TM1202 TM1202 TM1202 TM1203 TM1203 TM1203 TM1203 TM1204 TM1204 TM1204 TM1204 TM1578 TM1205 TM1217 TM1205 TM0372 X TM1206 TM1218 TM1206 X TM1581 TM1207 TM1219 TM1207 TM0945 TM0009 TM1875 TM1208 TM1220 TM1208 TM1851 TM1581 TM1209...”
- “...TM1833 TM1828 TM1417 TM1103 TM1835 TM1834 TM1834 TM0690 TM1836 TM1835 TM1835 TM1837 TM1836 TM1836 TM1838 TM1203 TM1203 TM1839 TM1839 TM1839 TM1840 TM1840 TM1840 TM1841 TM1841(split?) TM1841 TM1842 X TM1842 TM1843 X TM1843 TM1844 TM1844 TM1844 TM1845 TM1845 TM1845 Bold, transporter ORFs; Italics, has at least one...”
- Several archaeal homologs of putative oligopeptide-binding proteins encoded by Thermotoga maritima bind sugars
Nanavati, Applied and environmental microbiology 2006 - “...Annotated by TIGR (34) rbsC1 rbsA1 rbsB1 rbsD TM1202 TM1203 TM1204 MSP MSP SBP 1 malG1 malF1 malE1 Maltose transportc Annotated by TIGR (34) malG1 malF1 malE1...”
- Substrate specificities and expression patterns reflect the evolutionary divergence of maltose ABC transporters in Thermotoga maritima
Nanavati, Journal of bacteriology 2005 - “...(91% similar), the inner membrane protein homologs MalF1 (TM1203) and MalF2 (TM1837) are 59% identical (74% similar), and MalG1 (TM1202) and MalG2 (TM1836) are...”
- Whole-genome expression profiling of Thermotoga maritima in response to growth on sugars in a chemostat
Nguyen, Journal of bacteriology 2004 - “...TM1195, TM1196 TM1197 TM1198 TM1199 TM1200 TM1201 TM1202, TM1203, TM1204, TM1216 TM1837, TM1839, TM1840, Maltose vs glucose VOL. 186, 2004 4827 In aerobes and...”
- Maltose and maltodextrin transport in the thermoacidophilic gram-positive bacterium Alicyclobacillus acidocaldarius is mediated by a high-affinity transport system that includes a maltose binding protein tolerant to low pH
Hülsmann, Journal of bacteriology 2000 - “...putative membrane proteins of T. maritima (MalF, 41% with TM1203; MalG, 39% with TM1202). Compared to the E. coli MalF protein and consistent with membrane...”
SPD_1676 sugar ABC transporter, permease protein from Streptococcus pneumoniae D39
28% identity, 88% coverage
- A Tn-seq Screen of Streptococcus pneumoniae Uncovers DNA Repair as the Major Pathway for Desiccation Tolerance and Transmission
Matthews, Infection and immunity 2021 (secret) - N-acetylglucosamine-Mediated Expression of nagA and nagB in Streptococcus pneumoniae
Afzal, Frontiers in cellular and infection microbiology 2016 - “...Galactose-6-phosphate isomerase, LacA 9.9 spd_0280 Transcriptional regulator, CelR 7.7 spd_1677 Sugar ABC transporter, RafE 7.4 spd_1676 Sugar ABC transporter, RafF 6.6 spd_1634 Galactokinase, GalK 6.5 spd_1633 Galactose-1-phosphate uridylyltransferase, GalT 6.3 spd_1675 Sugar ABC transporter, RafG 5.6 spd_1047 PTS system, lactose-specific IIBC components, LacE 5.4 spd_0283 PTS...”
Rv2316 PROBABLE SUGAR-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER USPA from Mycobacterium tuberculosis H37Rv
P71896 Probable sugar-transport integral membrane protein ABC transporter UspA from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
28% identity, 92% coverage
- Assessing the propensity of TB clinical isolates to form viable but non-replicating subpopulations
Coetzee, Scientific reports 2024 - “...P9WHU1 prcA R135P 248 Proteasome core protein PrcA Rv2307c P9WLC7 rv2307c M24T 281 Uncharacterized protein Rv2316 P71896 uspA V127L 290 Probable sugar-transport integral membrane protein ABC transporter Rv2333c P9WG91 stp D69Y 537 Multidrug resistance protein Stp (Spectinomycin tetracycline efflux pump) Rv2347c P9WNI5 esxP T3S 98 ESAT-6-like...”
- Mechanistic Insight into the Enzymatic Inhibition of β-Amyrin against Mycobacterial Rv1636: In Silico and In Vitro Approaches
Beg, Biology 2022 - “...signaling pathway, which is essential in host protective immunity, albeit the exact mechanism is unknown. Rv2316 (uspA) is an integral membrane protein involved in the active transport of sugar across the membrane. This protein oversees transporting sugar across the membrane (import). The proteinchemical interaction using the...”
- “...signaling pathway, which is important in host protective immunity, albeit the exact mechanism is unknown. Rv2316 (UspA) is an integral membrane protein involved in the active transport of sugar across the membrane. STITCH server showed the interaction of Rv1636 with the SeMet, carboxy, chloride, nitrate, MgATP,...”
- ATP-binding cassette (ABC) import systems of Mycobacterium tuberculosis: target for drug and vaccine development
Soni, Emerging microbes & infections 2020 - “...Involved in biofilm formation [ 43 ] Amino-sugar importer (UspABC/Rv2316-Rv2318) SBP: UspC (Rv2318) TMD: UspA (Rv2316) and UspB (Rv2317) NBD: Remains to be identify Essential for in vitro growth [ 50 ] UspC have a substrate preference for sugars containing an amino group at the C2...”
- Whole genome sequencing reveals genomic heterogeneity and antibiotic purification in Mycobacterium tuberculosis isolates
Black, BMC genomics 2015 - “...targeted PCR and sanger sequencing Gene a Sanger chromatogram result Read frequency (%) Sanger result Rv2316 Single peak 127/127 (100.0) True Rv1703c Single peak 152/154 (98.7) True Rv0820 Single peak 193/200 (96.5) True Rv3220c Single peak 129/134 (96.3) True Rv0537c Single peak 98/126 (77.8) True Rv2692...”
- Assessing the propensity of TB clinical isolates to form viable but non-replicating subpopulations
Coetzee, Scientific reports 2024 - “...prcA R135P 248 Proteasome core protein PrcA Rv2307c P9WLC7 rv2307c M24T 281 Uncharacterized protein Rv2316 P71896 uspA V127L 290 Probable sugar-transport integral membrane protein ABC transporter Rv2333c P9WG91 stp D69Y 537 Multidrug resistance protein Stp (Spectinomycin tetracycline efflux pump) Rv2347c P9WNI5 esxP T3S 98 ESAT-6-like protein...”
LSEI_0990 ABC-type sugar transport system, permease component from Lactobacillus casei ATCC 334
27% identity, 91% coverage
- New Genes Involved in Mild Stress Response Identified by Transposon Mutagenesis in Lactobacillus paracasei
Palud, Frontiers in microbiology 2018 - “...0.50 * 1.58 0.44 LSEI_0938 Phosphate ABC transporter 3.35 0.69 * 1.01 0.25 1.34 0.39 LSEI_0990 Sugar ABC transporter 1.05 0.25 2.64 0.63 * 1.44 0.48 LSEI_1007 Spermidine/putrescine ABC transporter 2.33 0.54 * 4.05 1.13 * 1.35 0.52 LSEI_1041 DNA binding response regulator 1.35 0.29 1.41...”
- “...LSEI_0794 100 93 68 82 LSEI_0806 100 95 75 80 LSEI_0938 100 81 75 76 LSEI_0990 100 87 77 75 LSEI_1289 100 95 78 76 LSEI_1007 100 95 81 82 (P) LSEI_1041 100 83 63 68 LSEI_1293 100 88 84 90 LSEI_1360 100 93 84 88...”
XACH_HALVD / D4GP36 Xylose/arabinose import permease protein XacH from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii) (see paper)
HVO_B0035 ABC-type transport system permease protein (probable substrate sugar) from Haloferax volcanii DS2
30% identity, 67% coverage
- function: Part of the ABC transporter complex XacGHIJK involved in the uptake of xylose and arabinose (PubMed:31089701). Responsible for the translocation of the substrate across the membrane (Probable).
subunit: The complex is composed of two ATP-binding proteins (XacJ and XacK), two transmembrane proteins (XacH and XacI) and a solute-binding protein (XacG). - A sweet new set of inducible and constitutive promoters in Haloferax volcanii
Rados, Frontiers in microbiology 2023 - “...HVO_0562 64 ); 4 for xylose ( HVO_B0027 - 29 , HVO_B0030 - 32 , HVO_B0035 , and HVO_B0036 - 38 ); 3 for arabinose ( HVO_B0027 - 29 , HVO_B0030 - 32 , and HVO_B0035; and none for IPTG ( Figures 1C , D )....”
- D-xylose degradation pathway in the halophilic archaeon Haloferax volcanii
Johnsen, The Journal of biological chemistry 2009 - “...4-epimerase HVO_B0033, hypothetical protein HVO_B0034, unknown HVO_B0035, sugar ABC transporter permease protein HVO_B0036, ABC transporter permease protein...”
Tsac_1349 carbohydrate ABC transporter permease from Thermoanaerobacterium saccharolyticum JW/SL-YS485
27% identity, 88% coverage
lmo2124 similar to maltodextrin ABC-transport system (permease) from Listeria monocytogenes EGD-e
26% identity, 68% coverage
- The ribonuclease PNPase is a key regulator of biofilm formation in Listeria monocytogenes and affects invasion of host cells
Quendera, NPJ biofilms and microbiomes 2023 - “...), genes from the mannose/glucose ( lmo0096 , lmo0783 , lmo0784 ) and maltose ( lmo2124 , lmo2125 ) transport systems, along with genes involved in the pentose phosphate pathway ( lmo0342 , lmo0343 , lmo0345 ). The categories that were strongly downregulated by PNPase inactivation...”
- “...MpoB 4.44 1.9510 2 lmo0784 PTS mannose/glucose transporter subunit IIA, MpoA 4.36 2.1310 2 2.71 lmo2124 Maltose/maltodextrin ABC-transport system permease, MalF 10.59 7.7810 6 2.00 lmo2125 Maltose/maltodextrin ABC-transporter binding protein, MalE 15.09 2.3810 7 3.05 lmo0048 Sensor of histidine kinase, AgrB Quorum sensing system 8.59 4.3610...”
- Synergistic Antibacterial Mechanism of Mannosylerythritol Lipid-A and Lactic Acid on Listeria monocytogenes Based on Transcriptomic Analysis
Liu, Foods (Basel, Switzerland) 2022 - “...analyzed the transcription level of lmo0248 , lmo0249 , lmo2623 , lmo2628 , lmo2123 , lmo2124 , lmo2347, and lmo2348 by real-time quantitative PCR to verify the accuracy of the transcriptome data. It was highly consistent between the RNA-Seq and qPCR results (R 2 = 0.9903),...”
- Antibacterial Efficacy and Mechanism of Mannosylerythritol Lipids-A on Listeria monocytogenes
Liu, Molecules (Basel, Switzerland) 2020 - “...5, 4.6% of the genes with FC > 20, and there were two genes (lmo2125, lmo2124) with FC > 100. Overall, these results suggested that there was a significant difference between the MEL-A treatment group and the control group. 3.5.2. Gene Ontology (GO) Analysis The top...”
- “...the stress caused by MEL-A [ 31 ]. The expression of genes involved in localization (lmo2124, lmo1740, etc.), transport (lmo2124, lmo2123, lmo2347, etc.) and the establishment of localization were downregulated ( Figure 6 B). These genes are mainly predicted to be related to the transport of...”
- The Combined Effect of Cold and Copper Stresses on the Proliferation and Transcriptional Response of Listeria monocytogenes
Quesille-Villalobos, Frontiers in microbiology 2019 - “...as genes that encode the phosphotransferase system (PTS; genes lmo0027, lmo0298, lmo0299, lmo1997, lmo2000, lmo2001, lmo2124, lmo2125, lmo2665, lmo2666 and lmo2708) ( Figure 2B and Supplementary Table S2 ). The effect of copper over the carbohydrate metabolism has been described in other bacterial models. When a...”
- Maltose and maltodextrin utilization by Listeria monocytogenes depend on an inducible ABC transporter which is repressed by glucose
Gopal, PloS one 2010 - “...gene cluster was inactivated by plasmid insertion. The transcription of the representative genes lmo2121 , lmo2124 and lmo2126 was massively induced upon the addition of maltose or maltotriose when compared to sugar-free medium ( Figure 3 ). The gene for the putative transcriptional regulator Lmo2128 was...”
- “...10.1371/journal.pone.0010349.g003 Figure 3 Role of Lmo2128 in regulation. Transcription analysis by qRT-PCR for lmo2121 , lmo2124 , lmo2126 and lmo2128 in wild type (open bars) and in the Ins 2128 mutant (grey bars). The strains were grown at 37C in TSB without sugar or with 25...”
- Transcriptome analysis of alkali shock and alkali adaptation in Listeria monocytogenes 10403S
Giotis, Foodborne pathogens and disease 2010 - “...lmo2458 lmo1567 lmo1641 lmo2122 lmo1293 lmo1538 lmo1407 LMOf2365_1073 lmo1053 lmo2124 4.67 8.21 10.4 8.09 2.42 2.51 2.04 2 10.4 5.35 3.52 8.93 4.62 12 9.81 7.21...”
- “...of genes such as maltodextrin transporter (lmo2122, lmo2123, lmo2124, and lmo2126) suggests that initial uptake and processing of certain sugars, such as...”
- Deciphering the intracellular metabolism of Listeria monocytogenes by mutant screening and modelling
Schauer, BMC genomics 2010 - “...ABC transporter specific for metal cations no 5.8 2.3 metabolism of coenzymes and prosthetic groups lmo2124 maltodextrin ABC transport system, permease rf 3.4 0 5 lmo0221 hypothetical type III pantothenate kinase possible 6.9 1.0 1,3 oppF (lmo2192) oligopeptide ABC-transporter, ATP-binding protein no 21.0 8.0/4.0 1,3 pdxK...”
- Glycerol metabolism and PrfA activity in Listeria monocytogenes
Joseph, Journal of bacteriology 2008 - “...lmo2098 lmo2108 lmo2109 lmo2115 lmo2121a,b lmo2122 lmo2123 lmo2124 lmo2125b lmo2134 lmo2135 lmo2136 lmo2143 lmo2159b lmo2175 fruA lmo2341 lmo2389 lmo2434...”
- More
Blon_2369 binding-protein-dependent transport systems inner membrane component from Bifidobacterium longum subsp. infantis ATCC 15697
29% identity, 84% coverage
- Comparative Pangenomics of the Mammalian Gut Commensal Bifidobacterium longum
Albert, Microorganisms 2019 - “...membrane transport proteins (Blon_2331 and Blon_2332) to terminate with a carbohydrate ABC transporter membrane protein (Blon_2369), with carbohydrate-related enzymes and transporter components interspersed between [ 15 ]. The HMO utilization gene cluster was first identified in B. longum subspecies infantis ATCC15697 T and subsequently determined to...”
Ac3H11_793 ABC transporter for Glycerol, permease component 1 from Acidovorax sp. GW101-3H11
28% identity, 91% coverage
- mutant phenotype: Specific phenotypes on Glycerol. in a gene cluster for glycerol utilization; see phenotype on both strands
RL4244 putative transmembrane component of ABC transporter from Rhizobium leguminosarum bv. viciae 3841
31% identity, 76% coverage
TC 3.A.1.1.44 / Q9KZ07 Putative maltose permease, component of MalEFG (K unknown), involved in maltose and maltodextrin uptake from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
SCO2230 maltose permease from Streptomyces coelicolor A3(2)
29% identity, 94% coverage
BRA1182 sugar ABC transporter, permease protein, putative from Brucella suis 1330
BCAN_B1213 hypothetical protein from Brucella canis ATCC 23365
28% identity, 88% coverage
- ATP-Binding Cassette Systems of Brucella
Jenner, Comparative and functional genomics 2009 - “...BMEII0113, ugpA BruAb21118 BRA1181 BOV_A1085 BCAN_B1213 OSP Oligosaccharide or polyol import IM BMEII0114, ugpE BruAb21117 BRA1182 BOV_A1084 BCAN_B1212 OSP Oligosaccharide or polyol import BP BMEII0115 BruAb21116 BRA1180 BCAN_B1211 77 OSP Oligosaccharide or polyol import IM BMEII0541 BruAb20483 BRA0749 BOV_A0700 BCAN_B0757 OSP Oligosaccharide or polyol import IM...”
- ATP-Binding Cassette Systems of Brucella
Jenner, Comparative and functional genomics 2009 - “...BruAb21119 BRA1183 BOV_A1086 BCAN_B1214 OSP Oligosaccharide or polyol import IM BMEII0113, ugpA BruAb21118 BRA1181 BOV_A1085 BCAN_B1213 OSP Oligosaccharide or polyol import IM BMEII0114, ugpE BruAb21117 BRA1182 BOV_A1084 BCAN_B1212 OSP Oligosaccharide or polyol import BP BMEII0115 BruAb21116 BRA1180 BCAN_B1211 77 OSP Oligosaccharide or polyol import IM BMEII0541...”
SMc02872 ABC transporter for N-Acetyl-D-glucosamine, permease protein 1 from Sinorhizobium meliloti 1021
27% identity, 91% coverage
- mutant phenotype: Specific phenotypes on N-Acetyl-D-Glucosamine; N-Acetyl-D-Glucosamine.
TC 3.A.1.1.18 / Q8RJU9 NgcF, component of N-Acetylglucosamine/N,N'-diacetyl chitobiose porter (NgcK (C) not identified) from Streptomyces olivaceoviridis (Streptomyces corchorusii) (see paper)
27% identity, 91% coverage
- substrates: N,N'-diacetyl chitobiose, N-acetylglucosamine
TC 3.A.1.1.26 / O06990 MalF aka yvdH, component of The maltose porter, MdxEFG and MsmX from Bacillus subtilis (see 2 papers)
27% identity, 55% coverage
- substrates: Maltose
- The MsmX ATPase plays a crucial role in pectin mobilization by Bacillus subtilis
Ferreira, PloS one 2017 - “...in the C-terminal end of AraQ are boxed. Accession numbers: AraP (P94529), AraQ (P94530), MdxF (O06990), MdxG (O06991), GanP (O32261), GanQ (O07011), OpuAB (P46921), MalF (P02916), and MalG (P68183). 10.1371/journal.pone.0189483.t008 Table 8 Effect of mutations in AraP and AraQ in the uptake of -1,5-arabinotriose. Doubling time...”
BR0236 sugar ABC transporter, permease protein from Brucella suis 1330
32% identity, 73% coverage
- ATP-Binding Cassette Systems of Brucella
Jenner, Comparative and functional genomics 2009 - “...import IM BMEI1714, malG BruAb10231 BR0237 BOV_0230 BCAN_A0240 OSP Maltose import IM BMEI1715, malF BruAb10232 BR0236 BOV_0229 BCAN_A0239 OSP Maltose import BP BMEI1716 BruAb10230 BR0235 BOV_0228 BCAN_A0238 76 OSP Oligosaccharide or polyol import ABC BMEII0112, ugpC BruAb21119 BRA1183 BOV_A1086 BCAN_B1214 OSP Oligosaccharide or polyol import IM...”
BCAN_A0239 binding-protein-dependent transport systems inner membrane component from Brucella canis ATCC 23365
32% identity, 73% coverage
- ATP-Binding Cassette Systems of Brucella
Jenner, Comparative and functional genomics 2009 - “...BMEI1714, malG BruAb10231 BR0237 BOV_0230 BCAN_A0240 OSP Maltose import IM BMEI1715, malF BruAb10232 BR0236 BOV_0229 BCAN_A0239 OSP Maltose import BP BMEI1716 BruAb10230 BR0235 BOV_0228 BCAN_A0238 76 OSP Oligosaccharide or polyol import ABC BMEII0112, ugpC BruAb21119 BRA1183 BOV_A1086 BCAN_B1214 OSP Oligosaccharide or polyol import IM BMEII0113, ugpA...”
Balac_1598 MalF-type ABC sugar transport systems permease component from Bifidobacterium animalis subsp. lactis Bl-04
26% identity, 95% coverage
- An ATP Binding Cassette Transporter Mediates the Uptake of α-(1,6)-Linked Dietary Oligosaccharides in Bifidobacterium and Correlates with Competitive Growth on These Substrates
Ejby, The Journal of biological chemistry 2016 - “...the cytoplasm by the ABC transport system (Balac_1598, Balac_1597, and Balac_1610). The -galactosidase (Balac_1601) and the -(1,6)-glucosidase are responsible...”
- Genetic and physiological responses of Bifidobacterium animalis subsp. lactis to hydrogen peroxide stress
Oberg, Journal of bacteriology 2013 - “...Balac_1502 Balac_1503 Balat_0464 Balac_1081 Balac_1597 Balac_1598 Balac_1599 Balac_1601 Balac_1567 Balac_1568 Balac_1569 Balac_1570 Balac_1572 Balac_1573...”
- Transcriptional analysis of oligosaccharide utilization by Bifidobacterium lactis Bl-04
Andersen, BMC genomics 2013 - “...F 4.5 14.0 Balac_1597 ABC transporter, permease component Galactoside, Glucoside B,D,E Raffinose F 14.1 13.9 Balac_1598 ABC transporter, permease component Galactoside, Glucoside B,D,E Isomaltose F 20.1 18.6 Balac_1599 ABC transporter, oligosaccharide-binding protein Galactoside, Glucoside B,D,E Isomaltose F 17.8 16.7 Balac_1601 -galactosidase, GH36 Galactoside, Glucoside B,D,E Raffinose...”
TC 3.A.1.1.30 / Q88P37 GtsB (GLcF), component of Glucose porter, GtsABCD from Pseudomonas putida (strain KT2440) (see paper)
PP_1016 carbohydrate ABC transporter permease from Pseudomonas putida KT2440
PP1016 sugar ABC transporter, permease protein from Pseudomonas putida KT2440
29% identity, 87% coverage
- substrates: glucose
tcdb comment: The orthologue of GtsA (receptor) in P. aeruginosa (64% identical to the P. putida GtsA has been biochemically characterized (Stinson et al. 1977) and corresponds to the sequence with UniProt acc# Q9HZ48 (Friedhelm Pfeiffer, personal communication) - Comparative Transcriptome Analysis of Pseudomonas putida KT2440 Revealed Its Response Mechanisms to Elevated Levels of Zinc Stress
Peng, Frontiers in microbiology 2018 - “...Medium-chain-fatty acid CoA ligase PP_0944 fumC 1 2.2 0.07 4.50 0.77 Class II fumarate hydratase PP_1016 gtsB 0.11 0.07 0.08 0.00 Mannose/glucose ABC transporter permease PP_1017 gtsC 0.12 0.00 0.11 0.01 Mannose/glucose ABC transporter permease PP_1018 gtsD 0.17 0.01 0.13 0.01 Mannose/glucose ABC transporter ATP binding...”
- UEG Week 2024 Poster Presentations
, United European gastroenterology journal 2024 - UEG Week 2023 Poster Presentations
, United European gastroenterology journal 2023 - The ColRS system is essential for the hunger response of glucose-growing Pseudomonas putida
Putrinš, BMC microbiology 2011 - “...Probable localization# PP1015 gtsA sugar ABC transporter, periplasmic sugar binding protein 2 (269; 587) P PP1016 gtsB sugar ABC transporter, permease protein 2 (717; 972) CM PP1018 gtsD sugar ABC transporter, ATP-binding protein 2 (414; 1094) CM PP1019 oprB1 porin B1 3 (66; 146; 909) OM...”
- “...lysis. Knockouts of sugar transport genes located upstream of oprB1 , i.e., gtsA (PP1015), gtsB (PP1016), and gtsD (PP1018) also suppressed the lysis phenotype of the colR mutant. In addition to sugar transport genes, lysis was also suppressed by inactivation of the two-component system CbrA-CbrB, which...”
- Convergent peripheral pathways catalyze initial glucose catabolism in Pseudomonas putida: genomic and flux analysis
del, Journal of bacteriology 2007 - “...this, we found that the operon containing ORFs PP1015, PP1016, PP1017, PP1018, and PP1019, which encode a putative ABC glucose uptake system, was also induced...”
- “...PP3379 PP3382 PP3383 PP3384 PP3416 PP3417 PP3418 PP1015 PP1016 PP1017 PP1018 PP1019 Regulatory genes PP1012 PP1013 PP3380 PP3415 Other functions PP1014 PP2968...”
BOV_A1085 putative sugar ABC transporter, permease protein from Brucella ovis ATCC 25840
28% identity, 88% coverage
- ATP-Binding Cassette Systems of Brucella
Jenner, Comparative and functional genomics 2009 - “...ugpC BruAb21119 BRA1183 BOV_A1086 BCAN_B1214 OSP Oligosaccharide or polyol import IM BMEII0113, ugpA BruAb21118 BRA1181 BOV_A1085 BCAN_B1213 OSP Oligosaccharide or polyol import IM BMEII0114, ugpE BruAb21117 BRA1182 BOV_A1084 BCAN_B1212 OSP Oligosaccharide or polyol import BP BMEII0115 BruAb21116 BRA1180 BCAN_B1211 77 OSP Oligosaccharide or polyol import IM...”
TC 3.A.1.1.16 / Q8TZP9 MalF, component of Maltooligosaccharide porter (Maltose is not a substrate, but maltotriose is.) from Pyrococcus furiosus
PF1937 putative sugar transport inner membrane protein (malf-like) from Pyrococcus furiosus DSM 3638
30% identity, 83% coverage
BOV_0229 sugar ABC transporter, permease protein from Brucella ovis ATCC 25840
31% identity, 73% coverage
- ATP-Binding Cassette Systems of Brucella
Jenner, Comparative and functional genomics 2009 - “...IM BMEI1714, malG BruAb10231 BR0237 BOV_0230 BCAN_A0240 OSP Maltose import IM BMEI1715, malF BruAb10232 BR0236 BOV_0229 BCAN_A0239 OSP Maltose import BP BMEI1716 BruAb10230 BR0235 BOV_0228 BCAN_A0238 76 OSP Oligosaccharide or polyol import ABC BMEII0112, ugpC BruAb21119 BRA1183 BOV_A1086 BCAN_B1214 OSP Oligosaccharide or polyol import IM BMEII0113,...”
LMOf2365_2829 ABC transporter, permease protein from Listeria monocytogenes str. 4b F2365
29% identity, 83% coverage
ARAP_BACSU / P94529 Arabinooligosaccharides transport system permease protein AraP from Bacillus subtilis (strain 168) (see 3 papers)
TC 3.A.1.1.34 / P94529 L-arabinose transport system permease protein AraP, component of The arabinosaccharide transporter AraNPQMsmX. Transports α-1,5-arabinooligosaccharides, at least up to four L-arabinosyl units; the key transporter for α-1,5-arabinotriose and α-1,5-arabinotetraose, but not for α-1,5-arabinobiose which is transported by AraE. MsmX is also used by the MdxEFG-MsmX system (3.A.1.1.36) (Ferreira and Sá-Nogueira, 2010). Involved in the uptake of pectin oligosaccharides with either MsmX or YurJ as the ATPase from Bacillus subtilis (see 4 papers)
araP / GB|CAB14834.1 L-arabinose transport system permease protein AraP from Bacillus subtilis (see 4 papers)
27% identity, 85% coverage
- function: Part of the ABC transporter complex AraNPQ involved in the uptake of arabinooligosaccharides. Transports alpha-1,5- arabinooligosaccharides, at least up to four L-arabinosyl units (PubMed:20693325). Responsible for the translocation of the substrate across the membrane (Probable).
subunit: The complex is composed of two ATP-binding proteins (MsmX), two transmembrane proteins (AraP and AraQ) and a solute-binding protein (AraN). - substrates: Arabinosides
- CharProtDB Part of the binding-protein-dependent transport system for L-arabinose. Probably responsible for the translocation of the substrate across the membrane. Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily. Contains 1 ABC transmembrane type-1 domain
- The MsmX ATPase plays a crucial role in pectin mobilization by Bacillus subtilis
Ferreira, PloS one 2017 - “...Residues selected for deletion in the C-terminal end of AraQ are boxed. Accession numbers: AraP (P94529), AraQ (P94530), MdxF (O06990), MdxG (O06991), GanP (O32261), GanQ (O07011), OpuAB (P46921), MalF (P02916), and MalG (P68183). 10.1371/journal.pone.0189483.t008 Table 8 Effect of mutations in AraP and AraQ in the uptake...”
BMEI1715 MALTOSE TRANSPORT SYSTEM PERMEASE PROTEIN MALF from Brucella melitensis 16M
31% identity, 73% coverage
- ATP-Binding Cassette Systems of Brucella
Jenner, Comparative and functional genomics 2009 - “...BCAN_A0241 OSP Maltose import IM BMEI1714, malG BruAb10231 BR0237 BOV_0230 BCAN_A0240 OSP Maltose import IM BMEI1715, malF BruAb10232 BR0236 BOV_0229 BCAN_A0239 OSP Maltose import BP BMEI1716 BruAb10230 BR0235 BOV_0228 BCAN_A0238 76 OSP Oligosaccharide or polyol import ABC BMEII0112, ugpC BruAb21119 BRA1183 BOV_A1086 BCAN_B1214 OSP Oligosaccharide or...”
PS417_22140 glucose/xylose ABC transporter, permease component 2 from Pseudomonas simiae WCS417
29% identity, 87% coverage
- mutant phenotype: Specifically important for utilization of D-glucose 6-phosphate and D-xylose. Glucokinase (PS417_22685) is important for glucose-6-phosphate utilization, which implies that it is hydrolyzed to glucose before uptake.
BAB1_0239 Binding-protein-dependent transport systems inner membrane component from Brucella melitensis biovar Abortus 2308
31% identity, 73% coverage
- ClpP protease modulates bacterial growth, stress response, and bacterial virulence in Brucella abortus
Sun, Veterinary research 2023 - “...clpP . According to the proteomic analysis, the top 10 upregulated proteins were BAB2_0880, RibH2, BAB1_0239, BAB1_1744, UreG2, UbiG, BAB1_0241, SucC, BAB1_1964, and Bpt, while the top 10 down-regulated proteins were ClpS, BAB1_0115, BAB1_0018, BAB1_0296, BAB1_0875, BAB1_1435, BAB1_1357, BAB2_0019, BAB1_1214, and BAB2_0547. Integrated analysis revealed the...”
- Characterization of Three Small Proteins in Brucella abortus Linked to Fucose Utilization
Budnick, Journal of bacteriology 2018 - “...6, 2018 by guest BAB designation BAB1_0238 BAB1_0239 BAB1_0241 BAB1_0240 BAB1_0242 BAB1_0244 BAB1_0246 BAB1_0247 BAB1_0248 BAB1_0243 BAB1_0237 BAB1_0236 Small...”
- Transcriptome analysis of the Brucella abortus BvrR/BvrS two-component regulatory system
Viadas, PloS one 2010 - “...nitric-oxide reductase 0.6 BAB1_1573 clpA , chaperonin protein 0.6 BAB2_0118 vjbR , transcriptional regulator 0.5 BAB1_0239 malF , maltose transporter permease sugar 0.4 BAB2_1152 transcriptional regulator, AraC family 0.4 BAB1_0358 lipoprotein 0.3 BAB1_2094 hpr-K , phospho transferase system 0.2 BAB1_2093 bvrS , sensor protein 0.2 BAB1_2147...”
- “...ORF Gene name/Predicted function 2 - Ct BAB2_0061 virB8 , type IV secretion system 39.5 BAB1_0239 malF , maltose ABC transporter permease sugar 2.9 BAB2_0955 norC , nitric-oxide reductase 2.5 BAB1_0017 hydroxymethylglutaryl-CoA lyase 2.3 BAB2_0118 vjbR , transcriptional regulator 2.0 BAB1_1620 glycosyl transferase 1.9 BAB1_2091 pckA...”
PfGW456L13_1895 ABC transporter for D-Galactose and D-Glucose, permease component 1 from Pseudomonas fluorescens GW456-L13
28% identity, 86% coverage
- mutant phenotype: Specific phenotypes on D-Galactose; N L-Lysine. glucose is the C source for the N source experiments with a phenotype (i.e. lysine); may also transport fructose.
ACPL_4618 carbohydrate ABC transporter permease from Actinoplanes sp. SE50/110
31% identity, 82% coverage
Bcep1808_2708 binding-protein-dependent transport systems inner membrane component from Burkholderia vietnamiensis G4
31% identity, 81% coverage
Bbr_1859 carbohydrate ABC transporter permease from Bifidobacterium breve UCC2003
27% identity, 84% coverage
HVO_0531 ABC-type transport system permease protein (probable substrate sugar) from Haloferax volcanii DS2
28% identity, 84% coverage
TC 3.A.1.1.11 / Q93KC0 TogM, component of Saturated and unsaturated oligogalacturonide transporter, TogMNAB (transports di- to tetrasaccharide pectin degradation products which consist of D-galacuronate, sometimes with 4-deoxy-L-threo-5-hexosulose uronate at the reducing end of the oligosaccharide) (Hugouvieux-Cotte-Pattat et al. 2001). Regulated by pectin utilization regulator KdgR from Erwinia chrysanthemi (see paper)
28% identity, 84% coverage
- substrates: Oligogalacturonides
BBMN68_218 carbohydrate ABC transporter permease from Bifidobacterium longum subsp. longum BBMN68
26% identity, 96% coverage
FXV78_RS11790 carbohydrate ABC transporter permease from Mediterraneibacter gnavus ATCC 29149
26% identity, 89% coverage
Spro_4473 binding-protein-dependent transport systems inner membrane component from Serratia proteamaculans 568
30% identity, 42% coverage
PFLU4845 ABC transport system, membrane permease from Pseudomonas fluorescens SBW25
28% identity, 87% coverage
lmo2838 similar to sugar ABC transporter permease protein from Listeria monocytogenes EGD-e
28% identity, 83% coverage
GK0705 maltose/maltodextrin transport system (permease) from Geobacillus kaustophilus HTA426
26% identity, 68% coverage
BH1865 sugar transport system (permease) (binding protein dependent transporter) from Bacillus halodurans C-125
30% identity, 84% coverage
RL0092 putative transmembrane component of ABC transporter from Rhizobium leguminosarum bv. viciae 3841
28% identity, 92% coverage
YPTB0502 ABC type sugar transport system, permease protein from Yersinia pseudotuberculosis IP 32953
27% identity, 91% coverage
- IscR is essential for yersinia pseudotuberculosis type III secretion and virulence
Miller, PLoS pathogens 2014 - “...subunit) eif 2.2 YPTB1266 putative outer membrane-associated protease pla2 2.2 Transport and Binding Proteins (8) YPTB0502 ABC type sugar transport system, permease 2.0 YPTB0868 putative amino acid ABC transporter, permease 2.5 YPTB1724 SSS family proline symporter putP 2.4 YPTB1956 calcium/proton antiporter chaA 2.7 YPTB2011 SulP family...”
BKKJ1_0068 carbohydrate ABC transporter permease from Bifidobacterium catenulatum subsp. kashiwanohense
24% identity, 90% coverage
- Metabolism of the predominant human milk oligosaccharide fucosyllactose by an infant gut commensal
James, Scientific reports 2019 - “...name Function 2-FL vs Sorbitol 2-FL vs Lactose BKKJ1_0067 BKKJ1_0067 ABC transporter substrate-binding protein 8.12 BKKJ1_0068 BKKJ1_0068 ABC transporter permease 5.91 BKKJ1_0069 BKKJ1_0069 ABC transporter permease 5.71 BKKJ1_0206 BKKJ1_0206 6-phosphogluconate dehydrogenase 13.31 BKKJ1_0207 BKKJ1_0207 hypothetical protein 17.67 BKKJ1_0208 BKKJ1_0208 putative gluconokinase 17.21 BKKJ1_0336 BKKJ1_0336 hypothetical protein...”
NGCF_STRCO / O50500 Diacetylchitobiose uptake system permease protein NgcF from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) (see paper)
SCO6006 probable transmembrane transport protein from Streptomyces coelicolor A3(2)
31% identity, 73% coverage
- function: Part of the ABC transporter complex NgcEFG-MsiK involved in N,N'-diacetylchitobiose ((GlcNAc)2) uptake. Responsible for the translocation of the substrate across the membrane.
subunit: The complex is composed of two ATP-binding proteins (MsiK), two transmembrane proteins (NgcF and NgcG) and a solute-binding protein (NgcE). - NgcESco Acts as a Lower-Affinity Binding Protein of an ABC Transporter for the Uptake of N,N'-Diacetylchitobiose in Streptomyces coelicolor A3(2)
Iinuma, Microbes and environments 2018 - “...The gene cluster includes two additional ORFs encoding the putative ABC-type integral membrane proteins ( SCO6006 and SCO6007 ) that form a transporter permease ( Fig. S1 ). Regarding most streptomycetes sugar ABC transporters, the gene for the ATPase component was not included in the cluster...”
- “...orthologous proteins, namely 35% amino acid identity for the SCO6005 protein and NgcE, 44% for SCO6006 and NgcF, and 50% between SCO6007 and NgcG ( Fig. S1 ). In contrast, the other streptomycetes NgcE orthologues share between 80 to 91% amino acid identities throughout the full-length...”
- The dasABC gene cluster, adjacent to dasR, encodes a novel ABC transporter for the uptake of N,N'-diacetylchitobiose in Streptomyces coelicolor A3(2)
Saito, Applied and environmental microbiology 2007 - “...mutant but still occurred (Fig. 5B). Putative ORFs (SCO6005, SCO6006, and SCO6007) corresponding to the ngcEFG genes of S. olivaceoviridis are present in the S....”
PH1215 sugar-binding transport system permease protein from Pyrococcus horikoshii OT3
29% identity, 83% coverage
SACTE_0370 carbohydrate ABC transporter permease from Streptomyces sp. SirexAA-E
28% identity, 96% coverage
- Aerobic deconstruction of cellulosic biomass by an insect-associated Streptomyces
Takasuka, Scientific reports 2013 - “...During growth on xylan, two clusters of genes were up-regulated. One extended from SACTE_0357 to SACTE_0370, encoding proteins from the GH11, GH13, GH42, GH43, GH78, GH87, and CE4 families, a LacI-like transcriptional regulator, a secreted peptidase, and two sets of inner membrane transporters and associated solute...”
SCO3483 integral membrane transport protein from Streptomyces coelicolor A3(2)
28% identity, 98% coverage
A7MGF8 sn-glycerol-3-phosphate transport system permease protein UgpA from Cronobacter sakazakii (strain ATCC BAA-894)
26% identity, 87% coverage
Bbr_1657 carbohydrate ABC transporter permease from Bifidobacterium breve UCC2003
27% identity, 90% coverage
Ac3H11_2064 glucose ABC transporter, permease component 1 from Acidovorax sp. GW101-3H11
28% identity, 71% coverage
- mutant phenotype: Specifically important for utilizing glucose. Also mildly important for mannose utilization and likely transports it as well.
BF29_RS09830 carbohydrate ABC transporter permease from Heyndrickxia coagulans DSM 1 = ATCC 7050
27% identity, 55% coverage
Y11_07561 carbohydrate ABC transporter permease from Yersinia enterocolitica subsp. palearctica Y11
29% identity, 84% coverage
BAD_RS08280 carbohydrate ABC transporter permease from Bifidobacterium adolescentis ATCC 15703
24% identity, 94% coverage
- Combining of transcriptome and metabolome analyses for understanding the utilization and metabolic pathways of Xylo-oligosaccharide in Bifidobacterium adolescentis ATCC 15703
Yang, Food science & nutrition 2019 - “...ABC transporter, solutebinding protein 1,971.94 686.94 BAD_RS00815 1.48 araQ Sugar ABC transporter permease 911.12 326.41 BAD_RS08280 1.46 msmF Sugar ABC transporter permease 1,353.65 491.14 BAD_RS00810 1.45 yurN Sugar ABC transporter permease 762.04 278.86 BAD_RS03705 1.35 ABC transporter permease 91.4 35.95 BAD_RS00990 1.33 ABC transporter substratebinding protein...”
- “...bifidobacteria. Compared to xylose treatment, genes including the sugar transporter permease protein (encoded by BAD_RS00815, BAD_RS08280, BAD_RS00810, BAD_RS08205, BAD_RS03705, BAD_RS02260, BAD_RS07410) and transporter ATPbinding protein (encoded by BAD_RS02265, BAD_RS00495, BAD_RS04090, BAD_RS08375) were upregulated (Table 3 ), the same situation occurs in metabolites, including Lthreonine (meta_58), cellobiose...”
TTH_RS04965 carbohydrate ABC transporter permease from Thermus thermophilus HB8
28% identity, 87% coverage
- Comparison of carbohydrate ABC importers from Mycobacterium tuberculosis
De, BMC genomics 2021 - “...and white: environmental species, represented by M. smegmatis. The amino acid sequences of TTH_RS04960 and TTH_RS04965 from Thermus thermophilus , encoding putative carbohydrate TMDs, were used as outgroup. B Structural models of SugB, Rv2039c, UspB, UgpE and SugA, Rv2040c, UspA, and UgpA highlighting the regions that...”
HMPREF0421_20098 carbohydrate ABC transporter permease from Gardnerella vaginalis ATCC 14019
27% identity, 72% coverage
- Transcriptomic and Proteomic Analysis of Gardnerella vaginalis Responding to Acidic pH and Hydrogen Peroxide Stress
Zhang, Microorganisms 2023 - “...ABC transporters transported monosaccharides or oligosaccharides, providing oligosaccharides units for cell growth or biofilm formation (HMPREF0421_20098) [ 32 ]. Therefore, we can speculate that, while the formed biofilm increased the G. vaginalis tolerance to lactate and hydrogen peroxide [ 33 ], the lactobacilli were able to...”
- “...acetyltransferase HMPREF0421_20235 0.76 0.009039 Sugar ABC transporter membrane protein HMPREF0421_20979 0.76 0.001612 TM2 domain-containing protein HMPREF0421_20098 0.78 0.001898 Sugar ABC transporter membrane protein HMPREF0421_20232 0.81 0.003311 Maltose-binding protein HMPREF0421_20422 0.81 0.025688 Exopolyphosphatase HMPREF0421_20575 0.82 0.000581 Phosphate acetyltransferase HMPREF0421_21052 0.83 0.022516 RelE-family TA system toxin...”
ERH_1245 carbohydrate ABC transporter permease from Erysipelothrix rhusiopathiae str. Fujisawa
29% identity, 81% coverage
- Proteomic and Transcriptomic Analyses of Swine Pathogen Erysipelothrix rhusiopathiae Reveal Virulence Repertoire
Li, PloS one 2016 - “...Uncharacterized conserved protein up ERH_1687 gi|322463680 ABC transporter, permease protein 2.3 1 17.319 Unknown down ERH_1245 gi|336066678 glycosyltransferase family protein 32.8 11 1.543 ABC-type sugar transport systems, permease components down ERH_1442 gi|336065843 hypothetical protein (Glycosyltransferases) 15.4 2 1.706 Glycosyltransferases involved in cell wall biogenesis gi|336066252 dephospho-CoA...”
- The genome of Erysipelothrix rhusiopathiae, the causative agent of swine erysipelas, reveals new insights into the evolution of firmicutes and the organism's intracellular adaptations
Ogawa, Journal of bacteriology 2011 - “...ERH_0417, ERH_1083, ERH_1084, ERH_1085, ERH_1244, ERH_1245, ERH_1246, ERH_1523 ERH_0895, ERH_0896, ERH_1350, ERH_1351, ERH_1352, ERH_1517. ERH_1518, ERH_1519,...”
P18812 Maltose/maltodextrin transport system permease protein MalF from Klebsiella aerogenes
29% identity, 43% coverage
Blon_2379 binding-protein-dependent transport systems inner membrane component from Bifidobacterium longum subsp. infantis ATCC 15697
26% identity, 94% coverage
Ac3H11_2943 ABC transporter for D-Sorbitol, permease component 2 from Acidovorax sp. GW101-3H11
28% identity, 79% coverage
- mutant phenotype: Specific phenotypes on D-Sorbitol. The homolog in P. simiae WCS417 is probably a mannitol transporter as well.
BWI76_RS01825 maltose ABC transporter, permease component 1 (MalF) from Klebsiella michiganensis M5al
29% identity, 43% coverage
- mutant phenotype: Specifically important for utilizing D-Maltose monohydrate.
SACE_0925 binding-protein-dependent transport systems membrane component from Saccharopolyspora erythraea NRRL 2338
30% identity, 87% coverage
BMEII0113 SN-GLYCEROL-3-PHOSPHATE TRANSPORT SYSTEM PERMEASE PROTEIN UGPA from Brucella melitensis 16M
28% identity, 81% coverage
AT5A_19371 carbohydrate ABC transporter permease from Agrobacterium tumefaciens 5A
29% identity, 91% coverage
- Introducing the ArsR-Regulated Arsenic Stimulon
Rawle, Frontiers in microbiology 2021 - “...AT5A_19366 Sugar ABC transporter periplasmic sugar-binding protein 7.2 7.8 5.5 5.7 26.5 7.0 5.9 5.1 AT5A_19371 Sugar ABC transporter permease 5.7 6.3 6.1 4.3 25.4 5.4 4.7 4.0 AT5A_19376 Multiple sugar transport system permease protein 4.2 4.6 9.1 3.1 30.9 3.7 3.5 3.0 AT5A_19386 Sugar ABC...”
- “...direction upon As(III) exposure. An example of this pattern is the sugar transporter system (AT5A_19366, AT5A_19371, AT5A_19376, AT5A_19386) in the arsR1 mutant ( Supplementary Table 3 ). The third pattern involved no deviation from wild type in the absence of As(III), followed by a significant change...”
Atu3351 ABC transporter, membrane spanning protein (sugar) from Agrobacterium tumefaciens str. C58 (Cereon)
25% identity, 84% coverage
- Comparative Transcriptome Analysis of Agrobacterium tumefaciens Reveals the Molecular Basis for the Recalcitrant Genetic Transformation of Camellia sinensis L
Jin, Biomolecules 2022 - “...( atu0391 , atu4559 , atu4450 ), oligogalacturonide ( atu3130 , atu3132 ), glucose ( atu3351 , atu3352 ), rhamnose ( atu34873490 ), sn-glycerol 3-phosphate ( ugpC = atu3099 / atu3188 ), branched-chain amino acid ( livH = atu4518 , livG = atu4516 , livM =...”
LLKF_2261 sugar ABC transporter permease from Lactococcus lactis subsp. lactis KF147
27% identity, 82% coverage
Balac_0486 MalF-type ABC sugar transport systems permease component from Bifidobacterium animalis subsp. lactis Bl-04
27% identity, 86% coverage
- Structural Identity of Galactooligosaccharide Molecules Selectively Utilized by Single Cultures of Probiotic Bacterial Strains
Böger, Journal of agricultural and food chemistry 2019 - “...cross BLAST searches using the GosDEC gene from B. lactis 04 (Balac_0485, Acc. nr. WP_004268783.1; Balac_0486, Acc. nr. WP_004269047.1) and GalCDE gene from B. breve UCC2003 (Bbr_0417_galc, Acc. nr. WP_015438440.1; Bbr_0418_galD, Acc. nr. WP_025262769.1; Bbr_0419_galE, Acc. nr. WP_003828491.1) as a reference. Total number of candidate genes...”
- Transcriptional analysis of oligosaccharide utilization by Bifidobacterium lactis Bl-04
Andersen, BMC genomics 2013 - “...GOS C 11.4 17.2 Balac_0485 ABC transporter, permease component Galactoside A GOS C 8.4 16.2 Balac_0486 ABC transporter, permease component Galactoside A GOS C 5.7 12.9 Balac_0511 Xylose isomerase xyloside A,C XOS D 13.8 15.1 Balac_0512 - l -arabinofuranosidase, GH43 xyloside A,C XOS D 6.8 13.6...”
Psest_0864 maltose ABC transporter, permease component 1 (MalF) from Pseudomonas stutzeri RCH2
30% identity, 49% coverage
- mutant phenotype: Specifically important for utilizing D-Maltose monohydrate
SACTE_2288 carbohydrate ABC transporter permease from Streptomyces sp. SirexAA-E
28% identity, 72% coverage
- Aerobic deconstruction of cellulosic biomass by an insect-associated Streptomyces
Takasuka, Scientific reports 2013 - “...SACTE_3159 CBM33 CBM2 Cellulose-binding domain TGGGAGCGCTCCCA 3 16.2 SACTE_0482 GH5 CBM2 Endo-1,4-beta-glucosidase TGGGAGCGCTCCCA 4 15.4 SACTE_2288 Transport systems inner membrane component TGGGAGCGCTCCCA 5 11.2 SACTE_3717 GH9 CBM2 1,4-beta cellobiohydrolase TGGGAGCGCTCCCA 6 9.7 SACTE_6428 CBM33 Chitin-binding, domain 3 GGGAGCGCTCCCA 9 7.9 SACTE_2347 GH5 CBM2 Beta-mannosidase TGGGAGCGCTCCCA 11...”
RL4217 putative mannitol transmembrane permease component of ABC transporter from Rhizobium leguminosarum bv. viciae 3841
29% identity, 88% coverage
SCO1899 integral membrane sugar transport protein from Streptomyces coelicolor A3(2)
29% identity, 85% coverage
- The DeoR-like pleiotropic regulator SCO1897 controls specialised metabolism, sporulation, spore germination, and phosphorus accumulation in Streptomyces coelicolor
Fernández-García, Communications biology 2024 - “...average amino acid similarity of 92.2%, 88.2%, 86.1%, 89.1%, 91.6%, and 86.8% with SCO1897, SCO1898, SCO1899, SCO1900, SCO1901, and SCO1903 respectively (Fig. 1a ). SCO1902 was less conserved, showing an average similarity of 58.4% in these model Streptomyces strains. Fig. 1 The sco1897::Tn5 mutant phenotype and...”
- “...) was less abundant than transcript 1 ( sco1897 ) and that transcripts 3 ( sco1899 ) and 4 ( sco1900 ) were more abundant than transcript 2 ( sco1898 ) at 16 and 24h. The abundance of most of the transcripts decreased at 48h and...”
- From waste to health-supporting molecules: biosynthesis of natural products from lignin-, plastic- and seaweed-based monomers using metabolically engineered Streptomyces lividans
Seo, Microbial cell factories 2023 - “...SCO1901 100/99.6 SLYA8N_28215 Membrane sugar transporter, smoG SCO1900 100/99.8 SLYA8N_28220 Membrane sugar transport protein, smoF SCO1899 100/100 SLYA8N_28225 Substrate binding protein, smoE SCO1898 100/99.3 SLYA8N_28230 Transcriptional regulator deoR-type, smoR SCO1897 100/99.7 In terms of metabolic adjustment, the use of mannitol or protocatechuate as the growth substrate...”
LSEI_2764 ABC-type sugar transport system, permease component from Lactobacillus casei ATCC 334
27% identity, 88% coverage
SM_b21653 ABC transporter for Lactose, permease component 1 from Sinorhizobium meliloti 1021
SMb21653 probable lactose uptake ABC transporter permease protein from Sinorhizobium meliloti 1021
29% identity, 89% coverage
- mutant phenotype: Specific phenotypes on Beta-Lactose. Not important for arabinose utilization but there is no other clear arabinose tranpsorter so who knows
- Members of the Sinorhizobium meliloti ChvI regulon identified by a DNA binding screen
Bélanger, BMC microbiology 2013 - “...transporter) F14 143 3412878 3413020 inter SMc03297 pSymB F15 184 1266 1449 inter & intra SMb21653 ( lacF ) lactose ABC transporter, permease component F16 148 43628 43775 inter SMb20032 F17 150 132970 133119 inter SMb20119 putative site-specific recombinase F18 97 221089 221185 intra SMb20213 (upstream...”
Hlac_2863 binding-protein-dependent transport systems inner membrane component from Halorubrum lacusprofundi ATCC 49239
27% identity, 74% coverage
- Cloning, overexpression, purification, and characterization of a polyextremophilic β-galactosidase from the Antarctic haloarchaeon Halorubrum lacusprofundi
Karan, BMC biotechnology 2013 - “...family transposases; Hlac_2860, 2-keto-3-deoxy-6-phosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase; Hlac_2861, IclR family transcriptional regulator; Hlac_2862, sugar-binding periplasmid protein; Hlac_2863, ABC-type sugar transport system permease component; Hlac_2864, sugar permease; Hlac_2865, ABC-type sugar transport system; ATPase component; Hlac_2866, L-alanine-DL-glutamate epimerase and related enzymes of enolase; Hlac_2867, short-chain dehydrogenase/reductase SDR; Hlac_2868, -galactosidase;...”
PA14_22990 putative permease of ABC sugar transporter from Pseudomonas aeruginosa UCBPP-PA14
PA3189 probable permease of ABC sugar transporter from Pseudomonas aeruginosa PAO1
27% identity, 87% coverage
- Convergent phenotypic evolution towards fosfomycin collateral sensitivity of Pseudomonas aeruginosa antibiotic-resistant mutants
Laborda, Microbial biotechnology 2022 - “...glyoxylate cycle ( glcB and PA14_30050 ), as well as of the glucose transporters PA14_22980, PA14_22990 and PA14_23000, yet a decreased expression of lactate dehydrogenase encoding genes ( lldA and lldD ). Moreover, we also found increased expression of some genes that encode amino acid and...”
- Transcriptional profiling of Pseudomonas aeruginosa and Staphylococcus aureus during in vitro co-culture
Tognon, BMC genomics 2019 - “...GltK, ATP-binding component of ABC transporter transport PA14_23000 9.37 permease of ABC sugar transporter transport PA14_22990 9.19 permease of ABC sugar transporter transport PA14_23030 8.63 OprB, Glucose/carbohydrate porin transport bkdA2 8.05 2-oxoisovalerate dehydrogenase subunit beta aa metabolism bdhA 5.81 3-hydroxybutyrate dehydrogenase metabolism bkdB 4.93 branched-chain alpha-keto...”
- “...include the operon containing genes for the glucose/carbohydrate specific OprB porin and the adjacent ABC-transporters (PA14_22990 and PA14_23000) (10-fold decrease), the operon containing the OpdO porin and the co-transcribed ABC-transporter PA14_37250 (15 to 20-fold decrease), involved in pyroglutamate/lactam uptake as well as the gluconate permease gene...”
- Commensal colonization reduces Pseudomonas aeruginosa burden and subsequent airway damage
Stoner, Frontiers in cellular and infection microbiology 2023 - “...salivarius . Genes PA3186 ( oprB ), PA3187 ( gltK ), PA3188 ( gltG ), PA3189 ( gltF ), and PA3190 are involved in glucose uptake. PA3181 ( edaA ), PA3182 ( pgl ), and PA3183 ( zwf ) are involved in the catabolic conversion of...”
- “...(ATP binding component of ABC sugar transporter GltK), PA3188 (permease of ABC sugar transporter GltG), PA3189 (permease of ABC sugar transporter GltF), PA3190 (binding protein component of ABC sugar transporter), PA3191 (glucose transport sensor GtrS), and PA3192 (two-component response regulator GltR). (B) PAO1 intracellular glucose levels...”
- Catabolite repression control protein antagonist, a novel player in Pseudomonas aeruginosa carbon catabolite repression control
Sonnleitner, Frontiers in microbiology 2023 - “...component of ABC transporter PA3188 14.32 2.74E-8 PA 3188 Probable permease of ABC sugar transporter PA3189 12.67 4.63E-12 PA 3189 Probable permease of ABC sugar transporter PA3190 41.81 2.51E-71 PA 3190 Probable binding protein component of ABC sugar transporter PA3362 6.21 3.37E-18 amiS Hypothetical protein PA3363...”
- Responses of carbapenemase-producing and non-producing carbapenem-resistant Pseudomonas aeruginosa strains to meropenem revealed by quantitative tandem mass spectrometry proteomics
Salvà-Serra, Frontiers in microbiology 2022 - “...ABC sugar transporter 2 7 1.20 0.03 1.23 0.04 3.84 0.01 Down 1.26 0.01 WP_003091471.1 PA3189 GltF Probable permease of ABC sugar transporter 4 11 1.09 0.59 1.25 0.17 10.82 0.00 Down 1.30 0.09 WP_003091539.1 PA3228 - Probable ATP-binding/permease fusion ABC transporter 13 35 1.07 0.02...”
- Pseudomonas aeruginosa mutants defective in glucose uptake have pleiotropic phenotype and altered virulence in non-mammal infection models
Raneri, Scientific reports 2018 - “...0.1 6.7 ABC transporter ATP-binding protein PA3188 gltG 31.6 0.0 0.4 sugar ABC transporter permease PA3189 gltF 3.5 0.3 0.9 probable permease of ABC sugar transporter a Boldface characters, genes analysed by RT-qPCR. b Genes up- and down-regulated in GUN mutant with respect to PAO1 (with...”
- Gene expression in Pseudomonas aeruginosa swarming motility
Tremblay, BMC genomics 2010 - “...ATP-binding component of ABC transporter 2.6 PA3188 2 gltG permease of ABC sugar transporter 3.1 PA3189 gltF permease of ABC sugar transporter 2.5 PA3523 1 mexP probable Resistance-Nodulation-Cell Division (RND) efflux membrane fusion protein precursor 4.2 PA3920 1 cueA copper homeostasis P-type ATPase 2.6 PA5082 probable...”
- Identification, timing, and signal specificity of Pseudomonas aeruginosa quorum-controlled genes: a transcriptome analysis
Schuster, Journal of bacteriology 2003 - “...PA2939 PA3022 PA3032 PA3104 PA3181 PA3182 PA3183 PA3188 PA3189 PA3190 PA3194 PA3195 PA3274 PA3311 Description b VOL. 185, 2003 TRANSCRIPTOME ANALYSIS OF...”
PP_2262 sugar ABC transporter, permease protein from Pseudomonas putida KT2440
29% identity, 88% coverage
- Transcriptome Changes in Pseudomonas putida KT2440 during Medium-Chain-Length Polyhydroxyalkanoate Synthesis Induced by Nitrogen Limitation
Dabrowska, International journal of molecular sciences 2020 - “...responsible for the nitrogen metabolism pathway (NirB, NirD, CobA, and NasA), ABC transporters (PP_2260, PP_2261, PP_2262, PP_2263, UrtA, UrtB, UrtC, UrtD), and chemotaxis (PP_0779, PP_4888). Other genes code flagellar hook protein (FlgE), transglutaminase (PP_2686), and undetermined, hypothetical proteins (PP_2687, PP_2688, PP_3007, and PP_4331). 2.4. Validation of...”
- “...17.36 4.18 6.74 PP_2259 PP_2261 nd sugar ABC transporter ATP-binding protein 39.87 7.93 8.01 PP_2259 PP_2262 nd sugar ABC transporter permease 11.31 6.05 6.29 PP_2259 PP_2263 nd sugar ABC transporter permease 9.75 4.34 7.6 PP_2259 PP_5047 glnL ntrB 1.00* 5.82* 1.16 * PP_5048 glnG ntrC 1.00*...”
BBMN68_933 carbohydrate ABC transporter permease from Bifidobacterium longum subsp. longum BBMN68
27% identity, 96% coverage
- Mechanism analysis of acid tolerance response of bifidobacterium longum subsp. longum BBMN 68 by gene expression profile using RNA-sequencing
Jin, PloS one 2012 - “...BBMN68_195 GTGCCGCTCGTTGGCCGTAT TGGCCTCGTCGTCCAGCAGA 235 1.97 BBMN68_1099 GCACATTGCAACGCGACCCC ATGGCCAGCACGGCCACATC 160 1.93 BBMN68_1100 CAAGCAGGCCATCCCCACCG GGCCTTGGCCACTTCCTCGG 166 1.95 BBMN68_933 ACTACGTGCGCCTGTTGGGC GCGCCGTACACGAAACCCCA 226 2.01 BBMN68_1816 GCCGTGCCACCGACATCGAA CGATGCGGGCACGATCGACA 222 1.92 Determination of ATPase activity To investigate the role of ATPase in ATR in BBMN68, the activity of ATPase in the control...”
- “...protein BBMN68_931 1301.73 108.13 12.04 * G COG0395 K02026, multiple sugar transport system permease protein BBMN68_933 1443.31 95.75 15.07 * G COG1175 K02025, multiple sugar transport system permease protein BBMN68_1670 15246.02 1373.46 11.10 * G COG1653 K02027, multiple sugar transport system substrate-binding protein BBMN68_1671 904.42 246.04...”
PGA1_c13200 ABC transporter for D-Sorbitol, permease component 2 from Phaeobacter inhibens DSM 17395
28% identity, 92% coverage
- mutant phenotype: Specific phenotypes on D-Sorbitol; D-Sorbitol.
XNRR2_0970 carbohydrate ABC transporter permease from Streptomyces albidoflavus
31% identity, 90% coverage
- Superior production of heavy pamamycin derivatives using a bkdR deletion mutant of Streptomyces albus J1074/R2
Gläser, Microbial cell factories 2021 - “...of the phosphotransferase system (PTS), and a sugar transporter with presumed function as mannitol permease (XNRR2_0970) (Additional file 1 : Table S3). Additionally, two glycolytic genes, i. e. NADPH-dependent glyceraldehyde-3-phosphate dehydrogenase (XNRR2_0959) and pyruvate kinase (XNRR2_4449) were down-regulated (Additional file 1 : Table S3). Slight expression...”
- “...sugar uptake was diminished. The PTS genes (XNRR2_0028, XNRR2_0029), and the mannitol permease encoding gene (XNRR2_0970) were not downregulated in bkdR , different to the wild type. In addition, other PTS components (XNRR2_5450, XNRR2_5451) were slightly upregulated (Additional file 1 : Table S3). Genes associated to...”
OEOE_RS07035 carbohydrate ABC transporter permease from Oenococcus oeni PSU-1
30% identity, 77% coverage
BFP66_RS07040 carbohydrate ABC transporter permease from Streptococcus suis
26% identity, 83% coverage
- A novel aquaporin Aagp contributes to Streptococcus suis H2O2 efflux and virulence
Zhu, Virulence 2023 - “...sugar ABC transporters BFP66_RS00850 2.22 sugar ABC transporter permease; BFP66_RS02995 8.65 sugar ABC transporter permease; BFP66_RS07040 15.41 sugar ABC transporter permease; BFP66_RS07045 10.83 sugar ABC transporter substrate-binding protein; BFP66_RS08960 2.20 sugar ABC transporter substrate-binding protein; BFP66_RS00910 7.00 PTS sugar transporter subunit IIC; PTS system BFP66_RS02210 3.46...”
BPHYT_RS16110 ABC transporter for D-Sorbitol, permease component 2 from Burkholderia phytofirmans PsJN
29% identity, 79% coverage
- mutant phenotype: Specific phenotypes on D-Sorbitol.
BKKJ1_2078 carbohydrate ABC transporter permease from Bifidobacterium catenulatum subsp. kashiwanohense
24% identity, 87% coverage
- Metabolism of the predominant human milk oligosaccharide fucosyllactose by an infant gut commensal
James, Scientific reports 2019 - “...fumS ABC transporter solute binding protein 19.68 30.20 BKKJ1_2077 fumT1 ABC transporter permease 20.79 22.82 BKKJ1_2078 fumT2 ABC transporter permease 21.89 30.41 BKKJ1_2079 fumR LacI family transcriptional regulator The level of expression is shown as a fold-value of increase in expression on each carbohydrate, as compared...”
- “...and fumT2 (corresponding to locus tags BKKJ1_2076-2078, including the presumed promoter-containing region located upstream of BKKJ1_2078; this fragment was designated fumST1T2 ) were generated by PCR amplification from B. kashiwanohense APCKJ1 using Q5 High-Fidelity Polymerase (New England BioLabs, Herefordshire, UK) and primer pairs 2069pNZ44F and 2069pNZ44R,...”
BB562_10815 carbohydrate ABC transporter permease from Lactiplantibacillus pentosus
29% identity, 92% coverage
- Transcriptomic Profile and Probiotic Properties of Lactiplantibacillus pentosus Pre-adapted to Edible Oils
Alonso, Frontiers in microbiology 2021 - “...coding for an iron ABC transporter ATP-binding protein (BB562_08670), glycerol-3-phosphate ABC transporter permease (BB562_10810 and BB562_10815), glycerol-3-phosphate ABC transporter ATP-binding protein (BB562_10820), phosphate ABC transporter substrate-binding protein (BB562_13370 = 13420), phosphonate ABC transporter ATP-binding protein (BB562_13485), phosphonate ABC transporter permease protein PhnE (BB562_13490 gene was 4.29-fold...”
- “...and Supplementary Figure 3 ). In this case, we observed the absence of down-regulated gene BB562_10815 encoding glycerol-3-phosphate ABC transporter permease (ABC transporters), down-regulation of two additional genes coding for ribosome proteins (BB562_12015 and BB562_11990; Supplementary Table 2 and Supplementary Figure 3 ), and encoding serine...”
Blon_2204 binding-protein-dependent transport systems inner membrane component from Bifidobacterium longum subsp. infantis ATCC 15697
Blon_0341 binding-protein-dependent transport systems inner membrane component from Bifidobacterium longum subsp. infantis ATCC 15697
24% identity, 87% coverage
- Structure of co-expression networks of Bifidobacterium species in response to human milk oligosaccharides
González-Morelo, Frontiers in molecular biosciences 2023 - “...genes include transporters and enzymes for FL metabolism (Blon_0247, Blon_0248, Blon_0341 - Blon_0343, Blon_2202 - Blon_2204), which showed an important degree of co-expression. The Greenyellow network also included the GNB/LNB and type 1 HMO processing cluster (Blon_2172-Blon_2177), and galactose metabolism enzymes (Blon_2062-Blon_2063, Blon_2184) ( Supplementary Table...”
- 2'-Fucosyllactose Increases the Abundance of Blautia in the Presence of Extracellular Fucosidase-Possessing Bacteria
Horigome, Frontiers in microbiology 2022 - “...gene cluster encoding MAGB_040/MAGF_1420 contained fucosyllactose transporter genes, which were homologs of Blon_2202, Blon_2203, and Blon_2204. The copy numbers of MAGB_040/MAGF_1420 and the cell numbers of B. pseudocatenulatum in the culture medium were comparable after the fermentation of feces from non-responders in YCFA_2FL ( Supplementary Figure...”
- Strain-specific strategies of 2'-fucosyllactose, 3-fucosyllactose, and difucosyllactose assimilation by Bifidobacterium longum subsp. infantis Bi-26 and ATCC 15697
Zabel, Scientific reports 2020 - “...7 ). However, the average increase in the transcript abundance for the genes Blon_2202, Blon_2203, Blon_2204 was approximately 25% less on DFL than on 2FL or 3FL (74-fold average increase versus 100-fold respectively), especially pronounced for the SBP encoding gene Blon_2202. The locus encoding fucose utilization...”
- Comparative transcriptomics reveals key differences in the response to milk oligosaccharides of infant gut-associated bifidobacteria
Garrido, Scientific reports 2015 - “...and other gene clusters appear to be used instead. Genes Blon_0341 to Blon_0344, Blon_2202 to Blon_2204 and Blon_2305 to Blon_2309, were induced by 2FL, 3FL but no other substrates. These genes encode functions related to FL import through ABC transporters 23 , and putative enzymes participating...”
- Linking human milk oligosaccharide metabolism and early life gut microbiota: bifidobacteria and beyond
Lordan, Microbiology and molecular biology reviews : MMBR 2024 (secret) - Structure of co-expression networks of Bifidobacterium species in response to human milk oligosaccharides
González-Morelo, Frontiers in molecular biosciences 2023 - “...Supplementary Table S2 ). These genes include transporters and enzymes for FL metabolism (Blon_0247, Blon_0248, Blon_0341 - Blon_0343, Blon_2202 - Blon_2204), which showed an important degree of co-expression. The Greenyellow network also included the GNB/LNB and type 1 HMO processing cluster (Blon_2172-Blon_2177), and galactose metabolism enzymes...”
- Comparative transcriptomics reveals key differences in the response to milk oligosaccharides of infant gut-associated bifidobacteria
Garrido, Scientific reports 2015 - “...displayed only basal RPKM values, and other gene clusters appear to be used instead. Genes Blon_0341 to Blon_0344, Blon_2202 to Blon_2204 and Blon_2305 to Blon_2309, were induced by 2FL, 3FL but no other substrates. These genes encode functions related to FL import through ABC transporters 23...”
BBMN68_1423 carbohydrate ABC transporter permease from Bifidobacterium longum subsp. longum BBMN68
24% identity, 91% coverage
ERH_0414 carbohydrate ABC transporter permease from Erysipelothrix rhusiopathiae str. Fujisawa
24% identity, 89% coverage
- Proteomic and Transcriptomic Analyses of Swine Pathogen Erysipelothrix rhusiopathiae Reveal Virulence Repertoire
Li, PloS one 2016 - “...down ERH_1399 gi|336065655 ABC transporter permease 6.1 2 1.522 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific up ERH_0414 gi|336065992 citrate-sodium symporter 9.7 4 2.961 ABC-type sugar transport systems, permease components gi|336065983 GntR family transcriptional regulator 37.6 8 1.991 Na+/citrate symporter gi|336066469 hypothetical protein 16.9 2 1.753 Transcriptional regulators...”
- The genome of Erysipelothrix rhusiopathiae, the causative agent of swine erysipelas, reveals new insights into the evolution of firmicutes and the organism's intracellular adaptations
Ogawa, Journal of bacteriology 2011 - “...ERH_0199, ERH_0226, ERH_0227, ERH_0228, ERH_0413, ERH_0414, ERH_0417, ERH_1083, ERH_1084, ERH_1085, ERH_1244, ERH_1245, ERH_1246, ERH_1523 ERH_0895, ERH_0896,...”
SSUBM407_1448 multiple sugar-binding transport system permease protein from Streptococcus suis BM407
26% identity, 83% coverage
- Rapid evolution of virulence and drug resistance in the emerging zoonotic pathogen Streptococcus suis
Holden, PloS one 2009 - “...16 SSUBM407_1446 sucrose phosphorylase 1534855..1533407 32 SSUBM407_1447 multiple sugar-binding transport system permease protein 1535755..1534925 33 SSUBM407_1448 multiple sugar-binding transport system permease protein 1536641..1535766 23 SSUBM407_1449 multiple sugar-binding protein precursor 1538008..1536773 16 Region 7 SSUBM407_1489 conserved hypothetical protein 1572295..1571534 31 SSUBM407_1490 ABC-type glycine betaine transport system protein...”
Z5631 part of maltose permease, periplasmic from Escherichia coli O157:H7 EDL933
28% identity, 43% coverage
MalF / b4033 maltose ABC transporter membrane subunit MalF (EC 7.5.2.1) from Escherichia coli K-12 substr. MG1655 (see 14 papers)
MalF / P02916 maltose ABC transporter membrane subunit MalF (EC 7.5.2.1) from Escherichia coli (strain K12) (see 13 papers)
MALF_ECOLI / P02916 Maltose/maltodextrin transport system permease protein MalF from Escherichia coli (strain K12) (see 4 papers)
P02916 ABC-type maltose transporter (subunit 1/3) (EC 7.5.2.1) from Escherichia coli (see paper)
TC 3.A.1.1.1 / P02916 MalF aka B4033, component of Maltooligosaccharide porter. The 3-D structure has been reported by Oldham et al. (2007). An altering access mechanism has been suggested for the maltose transporter resulting from rigid-body rotations (Khare et al., 2009). Bordignon et al. (2010) and Schneider et al. (2012) have reviewed the extensive knowledge available on MalEFGK2, its mode of action and its regulatory interactions from Escherichia coli (see 14 papers)
NP_418457 maltose ABC transporter membrane subunit MalF from Escherichia coli str. K-12 substr. MG1655
b4033 maltose transporter subunit from Escherichia coli str. K-12 substr. MG1655
EcolC_3996 fructose-bisphosphate aldolase from Escherichia coli C str. ATCC 8739
28% identity, 43% coverage
- function: Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Probably responsible for the translocation of the substrate across the membrane.
subunit: The complex is composed of two ATP-binding proteins (MalK), two transmembrane proteins (MalG and MalF) and a solute-binding protein (MalE). Protein stability and stable complex formation require YidC. - substrates: Maltooligosaccharides, Maltose
tcdb comment: The transporter sequesters the MalT transcriptional activator at the cytoplasmic surface of the membrane in the absence of the transport substrate (Richet et al. 2012). The crystal structures of the transporter complex MBP-MalFGK2 bound with large malto-oligosaccharide in two different conformational states have also been determined. In the pretranslocation structure,Oldham et al. 2013 found that the transmembrane subunit MalG forms two hydrogen bonds with malto-oligosaccharide at the reducing end. In the outward-facing conformation, the transmrembrane subunit MalF binds three glucosyl units from the nonreducing end. These structural features explain why large modified malto-oligosaccharides are not transported by MalFGK2 despite their high binding affinity to MBP. In the transport cycle, substrate is channeled from MBP into the transmembrane pathway with a polarity such that both MBP and MalFGK2 contribute to the overall substrate selectivity of the system (Oldham et al. 2013). Stabilization of the semi-open MalK2 conformation by maltose-bound MBP is key to the coupling of maltose transport to ATP hydrolysis in vivo, because it facilitates the progression of the MalK dimer from the open to the semi-open conformation, from which it can proceed to hydrolyze ATP (Alvarez et al. 2015). Both the binding of MalE to the periplasmic side of the transmembrane complex and binding of ATP to MalK2 are necessary to facilitate the conformational change from the inward-facing state to the occluded state, in which MalK2 is completely dimerized (Hsu et al. 2017). An integrated transport mechanism of the maltose ABC importer has been proposed (Mächtel et al. 2019) - Biodistribution of 89Zr-DFO-labeled avian pathogenic Escherichia coli outer membrane vesicles by PET imaging in chickens
Li, Poultry science 2023 - “...Cell inner membrane 439 P0A6J5 DADA Amino acid transport and metabolism Cell inner membrane 440 P02916 MALF Carbohydrate transport and metabolism Cell inner membrane 441 P07117 PUTP Function unknown Cell inner membrane 442 P32703 YJCE Inorganic ion transport and metabolism Cell inner membrane 443 P60785 LEPA...”
- The MsmX ATPase plays a crucial role in pectin mobilization by Bacillus subtilis
Ferreira, PloS one 2017 - “...AraP (P94529), AraQ (P94530), MdxF (O06990), MdxG (O06991), GanP (O32261), GanQ (O07011), OpuAB (P46921), MalF (P02916), and MalG (P68183). 10.1371/journal.pone.0189483.t008 Table 8 Effect of mutations in AraP and AraQ in the uptake of -1,5-arabinotriose. Doubling time (min) of different strains in liquid minimal medium (CSK) using...”
- Evolutionary relationships of ATP-Binding Cassette (ABC) uptake porters.
Zheng, BMC microbiology 2013 - “...step [ 19 , 22 , 23 ]. The bacterial maltose transport system proteins, MalF (P02916) and MalG (P68183) are two distinct membrane proteins that together comprise the channel of an ABC superfamily member. High resolution structural information is available for this system (TC# 3.A.1.1.1). Consequently,...”
- Genes encoding two different beta-glucosidases of Thermoanaerobacter brockii are clustered in a common operon
Breves, Applied and environmental microbiology 1997 - “...proteins of metabolite transport systems: MalF (accession no. P02916), MalG (P07622), PotC (P23859) and CysW (P16702), all of E. coli, MsmF (Q00750) and MsmG...”
- Formation of a Chloride-conducting State in the Maltose ATP-binding Cassette (ABC) Transporter.
Carlson, The Journal of biological chemistry 2016 - GeneRIF: Data indicate that MalFGK2 transporter is comprised of two membrane proteins, MalF and MalG, and the nucleotide-binding domain, which controls the conformation of MalFG, is composed of the homodimeric MalK subunit.
- Allosteric transitions of the maltose transporter studied by an elastic network model.
Li, Biopolymers 2014 (PubMed)- GeneRIF: Data suggest that the binding and conformational change of maltose transporter (MalFGK2) may provide some insights into the understanding of the mechanism of ABC transporters.
- The ABC transporter MalFGK(2) sequesters the MalT transcription factor at the membrane in the absence of cognate substrate.
Richet, Molecular microbiology 2012 - GeneRIF: The molecular entity that interacts with MalT is not free MalK, but the maltose transporter, MalFGK(2) , which sequesters MalT to the membrane.
- Crystal structure of the maltose transporter in a pretranslocation intermediate state.
Oldham, Science (New York, N.Y.) 2011 (PubMed)- GeneRIF: using x-ray crystallography, study captured the maltose transporter in an intermediate step between the inward- and outward-facing states
- Studies of the maltose transport system reveal a mechanism for coupling ATP hydrolysis to substrate translocation without direct recognition of substrate.
Gould, The Journal of biological chemistry 2010 - GeneRIF: analysis of the MalFGK2 mechanism for coupling ATP hydrolysis to substrate translocation without direct recognition of substrate
- Biogenesis of MalF and the MalFGK(2) maltose transport complex in Escherichia coli requires YidC.
Wagner, The Journal of biological chemistry 2008 (PubMed)- GeneRIF: YidC supports the folding of MalF into a stable conformation before it is incorporated into the maltose transport complex
- ATP-driven MalK dimer closure and reopening and conformational changes of the "EAA" motifs are crucial for function of the maltose ATP-binding cassette transporter (MalFGK2).
Daus, The Journal of biological chemistry 2007 (PubMed)- GeneRIF: ATP-driven MalK dimer closure and reopening are crucial steps in the translocation cycle of the intact maltose transporter MalFGK2
- Maltose binding protein (MalE) interacts with periplasmic loops P2 and P1 respectively of the MalFG subunits of the maltose ATP binding cassette transporter (MalFGK(2)) from Escherichia coli/Salmonella during the transport cycle.
Daus, Molecular microbiology 2007 (PubMed)- GeneRIF: substrate availability is communicated from MalE to the MalK dimer via extracytoplasmic loops of MalFG
- More
- Effect of Global Regulators RpoS and Cyclic-AMP/CRP on the Catabolome and Transcriptome of Escherichia coli K12 during Carbon- and Energy-Limited Growth
Franchini, PloS one 2015 - “...i b4032 part of maltose permease, inner membrane 5.9 malF f , g , i b4033 part of maltose permease, periplasmic 6.9 malE c , f , g , i b4034 periplasmic maltose-binding protein 7.5 malK c , f , g , i b4035 ATP-binding component...”
- Global transcriptomic analysis of an engineered Escherichia coli strain lacking the phosphoenolpyruvate: carbohydrate phosphotransferase system during shikimic acid production in rich culture medium
Cortés-Tolalpa, Microbial cell factories 2014 - “...protein Transport 6.0726 malE b4034 Maltose ABC transporter - periplasmic binding protein Transport 174.0512 malF b4033 Maltose ABC transporter - membrane subunit Transport 19.1719 malK b4035 Maltose ABC transporter - ATP binding subunit Transport 14.8026 nmpC b0553 OMP protein; locus of qsr prophage Transport 11.7561 proX...”
- Escherichia coli toxin/antitoxin pair MqsR/MqsA regulate toxin CspD
Kim, Environmental microbiology 2010 - “...2.6 Maltodextrin phosphorylase malG b4032 1.6 1.5 2.0 Maltose transport complex, inner membrane-spanning subunit malF b4033 1.3 1.0 2.0 Maltose transport complex, inner membrane-spanning subunit malE b4034 1.5 1.1 3.5 Maltose-binding protein, periplasmic, substrate recognition for active transport of and chemotaxis toward maltose and maltodextrin malK...”
- Analysis of promoter targets for Escherichia coli transcription elongation factor GreA in vivo and in vitro
Stepanova, Journal of bacteriology 2007 - “...Isocitrate lyase (glyoxylate cycle) malG malF malE malK lamB malM b4032 b4033 b4034 b4035 b4036 b4037 2.1 3.2 1.9 4.2 3.1 4.5 2.8 3.7 5.8 7.5 7.1 6.5 Part of...”
- Genome-wide analyses of Escherichia coli gene expression responsive to the BaeSR two-component regulatory system
Nishino, Journal of bacteriology 2005 - “...b2989 b1886 b1923 b3128 b1885 b3126 b1884 b3690 b2473 b4105 b4033 b0958 aroF b2601 flgL malG fliD glpF fliT phnJ ycaC cheA b1083 b4032 b1924 b3927 b1926 b4098...”
- DNA microarray analyses of the long-term adaptive response of Escherichia coli to acetate and propionate
Polen, Applied and environmental microbiology 2003 - “...1.59 1.57* 1.50* 3.31* 2.67* 2.39 1.35* 1.46* 1.45 b4032 b4033 b4034 malG malF malE 1 1 1 Part of maltose permease, inner membrane Part of maltose permease,...”
- Physiological studies of Escherichia coli strain MG1655: growth defects and apparent cross-regulation of gene expression
Soupene, Journal of bacteriology 2003 - “...b4036 b4037 malK lamB malM 4.1 4.6 1.4 0.8 0.6 1.0 b4034 b4033 b4032 malE malF malG 5.2 1.6 1.5 0.7 0.7 1.0 b3417 b3416 malP malQ 3.9 2.9 0.3 0.6 b0679 nagE 0.9...”
- Combined, functional genomic-biochemical approach to intermediary metabolism: interaction of acivicin, a glutamine amidotransferase inhibitor, with Escherichia coli K-12
Smulski, Journal of bacteriology 2001 - “...b0274 b0051 b2568 b0072 b0071 b3455 b3460 b3458 b4024 b4033 b1620 b1817 b1530 b2328 b3829 b4242 Fold induction 0.37 0.31 0.41 0.13 0.47 0.27 0.49 0.36 0.10...”
- A novel point mutation in RpoB improves osmotolerance and succinic acid production in Escherichia coli
Xiao, BMC biotechnology 2017 - “...their expression maintained stable under osmotic stress. For example, transcript levels of malE (EcolC_3995), malF (EcolC_3996), malG (EcolC_3997) malK (EcolC_3994), and lamB (EcolC_3993), which encode individual subunits of the maltose ABC (ATP-binding cassette) transporter, decreased 10- to 14- fold in Suc-T110 compared to the corresponding levels...”
E2348C_4348 maltose ABC transporter permease MalF from Escherichia coli O127:H6 str. E2348/69
28% identity, 43% coverage
PGA1_c27940 N-Acetyl-D-glucosamine ABC transport system, permease component 1 from Phaeobacter inhibens DSM 17395
26% identity, 89% coverage
- mutant phenotype: Specific phenotypes on N-Acetyl-D-Glucosamine.
4ki0F / P02916 Crystal structure of the maltose-binding protein/maltose transporter complex in an outward-facing conformation bound to maltohexaose (see paper)
29% identity, 43% coverage
- Ligand: alpha-d-glucopyranose (4ki0F)
SPy0254 sugar transport system (permease) from Streptococcus pyogenes M1 GAS
24% identity, 89% coverage
Tsac_0150 carbohydrate ABC transporter permease from Thermoanaerobacterium saccharolyticum JW/SL-YS485
27% identity, 89% coverage
- Dynamic cell responses in Thermoanaerobacterium sp. under hyperosmotic stress
Zhu, Scientific reports 2017 - “...6.4941.230 Tsac_1295 Galactokinase 2.38E-03 7.989 2.7800.085 Tsac_1296 UDP-glucose 4-epimerase 1.51E-02 5.780 3.0610.270 ko02010: ABC transporters Tsac_0150 ABC-type transporter, integral membrane subunit 1.07E-02 7.972 1.4500.283 Tsac_0151 Extracellular solute-binding protein family 1 2.38E-03 8.140 1.6680.139 Tsac_2231 Extracellular ligand-binding receptor 6.67E-03 8.017 1.3040.023 ko00250: Alanine, aspartate and glutamate metabolism...”
NGR_c17820 carbohydrate ABC transporter permease from Sinorhizobium fredii NGR234
NGR_c17820 putative transmembrane component of ABC transporter from Rhizobium sp. NGR234
25% identity, 84% coverage
Bbr_0027 carbohydrate ABC transporter permease from Bifidobacterium breve UCC2003
26% identity, 89% coverage
TC 3.A.1.1.28 / Q00750 MsmF aka SMU.879, component of The raffinose/stachyose transporter, MsmEFGK (MalK (3.A.1.1.27) can probably substitute for MsmK; Webb et al., 2008). This system may also transport melibiose, isomaltotriose and sucrose as well as isomaltosaccharides from Streptococcus mutans (see 2 papers)
SMU_RS04085 carbohydrate ABC transporter permease from Streptococcus mutans UA159
28% identity, 88% coverage
- substrates: Raffinose, Stachyose
- Identification of the antibacterial action mechanism of diterpenoids through transcriptome profiling
Moon, Frontiers in microbiology 2022 - “...phosphorylase gtfA 0.98 1.69 1.71 SMU_RS04105 Alpha-glucosidase dexB 1.28 1.23 1.25 SMU_RS04075 Alpha-galactosidase aga 1.21 SMU_RS04085 Sugar ABC transporter permease msmF 1.76 0.33 0.45 SMU_RS04090 Carbohydrate ABC transporter permease msmG 1.20 0.26 0.14 SMU_RS04100 sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC msmK 1.95 0.66 0.59 SMU_RS07115 Sugar...”
TTC1287 No description from Thermus thermophilus HB27
30% identity, 58% coverage
TTHA1651 maltose ABC transporter, permease protein from Thermus thermophilus HB8
29% identity, 58% coverage
SPO_RS09350 carbohydrate ABC transporter permease from Ruegeria pomeroyi DSS-3
26% identity, 87% coverage
SMc04258 ABC transporter for D-Cellobiose and D-Salicin, permease component 2 from Sinorhizobium meliloti 1021
SMc04258 PUTATIVE TRANSPORT SYSTEM PERMEASE ABC TRANSPORTER PROTEIN from Sinorhizobium meliloti 1021
25% identity, 84% coverage
- mutant phenotype: Specific phenotypes on D-Cellobiose; D-Salicin.
- Temporal expression program of quorum sensing-based transcription regulation in Sinorhizobium meliloti
Charoenpanich, Journal of bacteriology 2013 - “...sites upstream of cspA3, nesR, SMb21135, SMc01524, SMc04246, and SMc04258 are among the weakest. For the SMc04258 and nesR promoters, a weak shift is observable...”
- “...(exoP2), SMc01711, SMc03149, SMc04032 (nesR), SMc04232, and SMc04258. For regions containing an ExpR binding site but lacking detectable promoter activity, it...”
GM298_18020 sn-glycerol-3-phosphate ABC transporter permease UgpA from Enterobacter sp. HSTU-ASh6
26% identity, 88% coverage
LMH90_004140 sn-glycerol-3-phosphate ABC transporter permease UgpA from Enterobacter hormaechei
26% identity, 88% coverage
TM1234 sugar ABC transporter, permease protein from Thermotoga maritima MSB8
28% identity, 88% coverage
Cthe_2126 binding-protein-dependent transport systems inner membrane component from Clostridium thermocellum ATCC 27405
Cthe_2126 carbohydrate ABC transporter permease from Acetivibrio thermocellus ATCC 27405
28% identity, 77% coverage
NP_463093 maltose transport protein from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
29% identity, 43% coverage
A8AXS5 Transmembrane permease MsmF from Streptococcus gordonii (strain Challis / ATCC 35105 / BCRC 15272 / CH1 / DL1 / V288)
SGO_1304 transmembrane permease MsmF from Streptococcus gordonii str. Challis substr. CH1
26% identity, 76% coverage
lmo0860 similar to sugar ABC transporter, permease protein from Listeria monocytogenes EGD-e
LMRG_02283 sugar ABC transporter, permease protein from Listeria monocytogenes 10403S
26% identity, 86% coverage
- Genome-wide analyses reveal lineage specific contributions of positive selection and recombination to the evolution of Listeria monocytogenes
Orsi, BMC evolutionary biology 2008 - “..., lmo1623 , lmo1790 , lmo2262 , pepC , lmo2391 , trxB , lmo0190 , lmo0860 , lmo0877 , lmo1087 , proA , lmo0992 , smbA , lmo1401 , lmo1420 , opuCC , trpD , lmo1693 , purK , lmo1825 , panB , lmo0028 , lmo2175...”
- “..., lmo2262 , pepC ( lmo2338 ), lmo2391 , trxB ( lmo2478 ), lmo0190 , lmo0860 , lmo0877 , lmo1087 , proA ( lmo1259 ), lmo0992 , smbA ( lmo1313 ), lmo1401 , lmo1420 , opuCC ( lmo1426 ), trpD ( lmo1631 ), lmo1693 , purK...”
- Glycerol metabolism and PrfA activity in Listeria monocytogenes
Joseph, Journal of bacteriology 2008 - “...lmo0782b lmo0783 lmo0784b lmo0810 lmo0813 uhpTb,d lmo0859 lmo0860 lmo0861 lmo0862 lmo0865 lmo0875 lmo0876 lmo0877 lmo0878 lmo0880 lmo0913b lmo0914 lmo0915b...”
- Listeria monocytogenes 10403S Alternative Sigma-54 Factor σL Has a Negative Role on Survival Ability Under Bile Exposure
Boonmee, Frontiers in microbiology 2021 - “...Of these, we could only confirm the negative regulation of L in csbD and possibly LMRG_02283 . It was clearly shown that in the absence of L in L mutant, csbD transcription was significantly induced. In contrast to the presence of L in BCH background, where...”
- Listeria monocytogenes σA Is Sufficient to Survive Gallbladder Bile Exposure
Boonmee, Frontiers in microbiology 2019 - “...housekeeping genes and (ii) gadT2 , plcA , LMRG_00091 , LMRG_01149 , LMRG_01669 , and LMRG_02283 for sigma A function. A list of TaqMan primers and probes designed by PrimerQuest (IDT DNA, Coralville, IA, United States) are shown in Table 1 . TaqMan probes were synthesized...”
- “...Pleitner et al., 2014 CGATCTTGGAGAGCCGAAATA CGGTAGAAGAATCTAAGAAC GAGCCGCATAGTTTGCATCAC LMRG_01149 GAGCATCTATCCCTCCAGAAATTA TAGGAACTGCCTTCGCGATTTCGA AATCCCAAGAGCTAACGCTAC LMRG_01669 GATTTCGCAAAGACTCGGATTAC TTGCACCAAGTTTGCGAGAATGGC ACGACGACGAATCGCTTT LMRG_02283 GTCATTTACCAGCCCGTATCTC AGTACCGCTTGTTTGGTCAATTTGGT CGGACTCATCATGTTCCAATCA All sequences are written 53. Results L. monocytogenes Lacking All Alternative Sigma Factors Has Similar Phenotype as Its Parental Strain To examine the survival ability under bile...”
SeseC_01630 carbohydrate ABC transporter permease from Streptococcus equi subsp. zooepidemicus ATCC 35246
25% identity, 63% coverage
B9H01_RS10260 sugar ABC transporter permease from Streptococcus suis
25% identity, 56% coverage
ACPL_5585 carbohydrate ABC transporter permease from Actinoplanes sp. SE50/110
27% identity, 88% coverage
Blon_2176 binding-protein-dependent transport systems inner membrane component from Bifidobacterium longum subsp. infantis ATCC 15697
28% identity, 75% coverage
- Bifidobacterium infantis treatment promotes weight gain in Bangladeshi infants with severe acute malnutrition
Barratt, Science translational medicine 2022 - “...Escherichia, Shigella, Klebsiella and Streptococcus species ( fig. S1A , B , table S1D ). Blon_2176 , part of the H5 gene cluster, encodes the permease component of the ABC transporter for a prominent lacto-N-biose type I tetrasaccharide in breast milk. A qPCR assay using primers...”
- “...samples from children with SAM compared to healthy Bangladeshi children that had detectable amounts of Blon_2176 (38% versus 66%, respectively; P <0.05, two proportion Z test; table S1A ). Colonization of Bangladeshi infants with SAM by milk-adapted B. infantis EVC001 Given the deficiency of B. infantis...”
- Human Milk Oligosaccharide Utilization in Intestinal Bifidobacteria Is Governed by Global Transcriptional Regulator NagR
Arzamasov, mSystems 2022 - “...-acetylhexosamine phosphorylase EC 2.4.1.211 63 Blon_2175 gltC LNT/LNB/GNB ABC transporter permease protein 2 TC 3.A.1.1.48 Blon_2176 gltB LNT/LNB/GNB ABC transporter permease protein 1 TC 3.A.1.1.48 Blon_2177 gltA LNT/LNB/GNB ABC transporter substrate-binding protein TC 3.A.1.1.48 39 Blon_2331 lacS2 Lactose MFS permease-2 TC 2.A.2 Blon_2332 lacS Lactose MFS...”
- Comparative Genome Analysis of Bifidobacterium longum subsp. infantis Strains Reveals Variation in Human Milk Oligosaccharide Utilization Genes among Commercial Probiotics
Duar, Nutrients 2020 - “...Group 1 and Group 2 occurred in the H5 cluster. Specifically, in the genes Blon_2175, Blon_2176 to Blon_2177 encoding an ABC-type transporter predicted to uptake lacto- N -biose ( Figure 1 b). Further examination, by aligning this genomic region in representative strains from Group 1 (ATCC...”
- “...Group 2 (NLS and BB-02(DSM 33361)) ( Figure 2 a), revealed that the genes Blon_2175, Blon_2176 and Blon_2177 are in fact absent from the Group 2 strains ( Figure 2 a). This same region in the EVC001 and ATCC 15697 strains presented a high degree of...”
- Inefficient Metabolism of the Human Milk Oligosaccharides Lacto-N-tetraose and Lacto-N-neotetraose Shifts Bifidobacterium longum subsp. infantis Physiology
Özcan, Frontiers in nutrition 2018 - “...moieties ( 16 ). Three F1SBPs (Blon_0883, Blon_2344 and Blon_2347) and four ABC permeases (Blon_2175, Blon_2176, Blon_2345 and Blon_2346) were induced more than 2-fold during the growth on LNT or LNnT as the sole carbon source relative to lactose ( p < 0.05). Only Blon_2347 expression...”
- “.... Genes involved in galactose metabolism (Blon_2171, Blon_2172, and Blon_2174) and adjacent ABC transporters (Blon_2175, Blon_2176, and Blon_2177) are strongly upregulated by both LNT and LNnT compared to lactose ( p < 0.05) (Figure 5 ). Moreover, LNnT prompted stronger induction of these genes relative to...”
- Exposure of Bifidobacterium longum subsp. infantis to Milk Oligosaccharides Increases Adhesion to Epithelial Cells and Induces a Substantial Transcriptional Response
Kavanaugh, PloS one 2013 - “...1.40 0.0200 1.55 0.0060 1.75 0.0020 Blon_2175 Solute transport 1.35 0.0300 1.56 0.0030 1.43 0.0100 Blon_2176 Solute transport 1.46 0.0060 1.63 0.0010 1.51 0.0020 Blon_2341 Hypothetical protein 1.29 0.0190 1.33 0.0100 1.73 0.0020 Blon_2379 Transport system inner membrane protein 1.55 0.0070 1.41 0.0200 1.85 0.0020 Blon_2380...”
- Analysis of predicted carbohydrate transport systems encoded by Bifidobacterium bifidum PRL2010
Turroni, Applied and environmental microbiology 2012 - “...Bbr_1892 Blon_2183 Blon_2331 Blon_0342 Blon_2015 Blon_2177 Blon_2176 Blon_2175 Blon_1050 Blon_2471 Blon_0129 B. longum subsp. infantis ATCC 15697 BLD_1757...”
- Broad conservation of milk utilization genes in Bifidobacterium longum subsp. infantis as revealed by comparative genomic hybridization
LoCascio, Applied and environmental microbiology 2010 - “...occurred specifically in three family 1 SBPs (Blon_2175, Blon_2176, and Blon_2177), while the rest of the cluster, including the LNB phosphorylase (LnpA;...”
SPD_1494 sugar ABC transporter, permease protein from Streptococcus pneumoniae D39
24% identity, 86% coverage
- N-acetylglucosamine-Mediated Expression of nagA and nagB in Streptococcus pneumoniae
Afzal, Frontiers in cellular and infection microbiology 2016 - “...system, mannose-specific IIC component, ManM 3.2 spd_0262 PTS system, mannose/fructose/sorbose family protein, IID component 3.0 spd_1494 Sugar ABC transporter, permease protein 2.7 spd_1493 Sugar ABC transporter, permease protein 2.4 spd_1866 N-acetylglucosamine-6-phosphate deacetylase, NagA 2.4 spd_1846 PTS system, IIB component 2.3 spd_1246 glucosamine-6-phosphate isomerase, NagB 2.3 spd_0264...”
- N-acetylgalatosamine-Mediated Regulation of the aga Operon by AgaR in Streptococcus pneumoniae
Afzal, Frontiers in cellular and infection microbiology 2016 - “...Hypothetical protein 7.4 spd_1492 Hypothetical protein 3.9 spd_1493 Sugar ABC transporter, permease protein, NanW 4.8 spd_1494 Sugar ABC transporter, permease protein, NanV 2.5 spd_1495 Sugar ABC transporter, sugar-binding protein, NanU 6.4 spd_1496 PTS system, IIBC components, NanP 3.2 spd_1497 N-acetylmannosamine-6-phosphate 2-epimerase 2, NanE 3.1 spd_1504 Sialidase...”
- Sialic acid-mediated gene expression in Streptococcus pneumoniae and role of NanR as a transcriptional activator of the nan gene cluster
Afzal, Applied and environmental microbiology 2015 - “...spd_1488 spd_1489 spd_1490 spd_1491 spd_1492 spd_1493 spd_1494 spd_1495 spd_1496 spd_1497 spd_1504 spd_1505 spd_1800 spd_2012 spd_2013 Downregulated genes...”
- “...spd_1491 spd_1492 spd_1493 5.0 4.6 spd_1495 5.9 spd_1494 spd_1496 spd_1497 a D39 annotation or TIGR4 annotation (27). PTS, phosphotransferase system. Fold...”
- Transcriptional and metabolic effects of glucose on Streptococcus pneumoniae sugar metabolism
Paixão, Frontiers in microbiology 2015 - “...1.48 SPD_1409 Sugar ABC transporter, ATP-binding protein 0.52 SPD_1493 Sugar ABC transporter, permease protein 0.61 SPD_1494 Sugar ABC transporter, permease protein 0.54 SPD_1495 Sugar ABC transporter, sugar-binding protein 0.56 SPD_1496 PTS system, IIBC components 0.48 0.72 SPD_1832 PTS system, IIB component 0.54 SPD_1833 PTS system, IIA...”
- Host glycan sugar-specific pathways in Streptococcus pneumoniae: galactose as a key sugar in colonisation and infection [corrected]
Paixão, PloS one 2015 - “...17.6 SPD_0559 PTS system transporter subunit IIA 15.1 SPD_0560 PTS system transporter subunit IIB 12.1 SPD_1494 Sugar ABC transporter permease 10.3 SPD_0070 agaS Sugar isomerase 9.8 SPD_0063 strH Beta-N-acetylhexosaminidase 8.7 SPD_1663 treC Alpha,alpha-phosphotrehalase 8.0 SPD_0066 PTS system transporter subunit IIB 7.8 SPD_0287 Hyaluronate lyase 7.7 SPD_1495...”
Bbr_0107 carbohydrate ABC transporter permease from Bifidobacterium breve UCC2003
25% identity, 80% coverage
SPD_RS07940 carbohydrate ABC transporter permease from Streptococcus pneumoniae D39
24% identity, 87% coverage
- SPD_0410 negatively regulates capsule polysaccharide synthesis and virulence in <i>Streptococcus pneumoniae</i> D39
Tao, Frontiers in microbiology 2024 - “...SPD_RS05200 spd_0966 Sugar ABC transporter permease 1.05367 2.61E-07 SPD_RS07935 satC Carbohydrate ABC transporter 1.25945 2.60E-06 SPD_RS07940 satB Sugar ABC transporter permease 1.20096 0.000206 Phosphotransferase system SPD_RS00335 gadV PTS system mannose/fructose/N-acetylgalactosamine-transporter subunit IIB 1.76673 9.74E-06 SPD_RS00340 gadW PTSmannose/fructose/sorbose/N- PTS system mannose/fructose/sorbose family transporter subunit IID 1.87046 3.00E-06...”
SP_1682 sugar ABC transporter, permease protein from Streptococcus pneumoniae TIGR4
24% identity, 87% coverage
- Biofilm formation in Streptococcus pneumoniae
Domenech, Microbial biotechnology 2012 - “...( fibA /SP_0615, murE /SP_1531, murB /SP_1390), the ABC and PTS transporters ( aliB /SP_1527, SP_1682, SP_0137), the proteolytic and ATPbinding subunits of the Clp proteases family ( clpP /SP_0746, clpX /SP_1569, clpC /SP_1294), the components of the shikimate pathway for synthesis of isochorismate ( aroK...”
- Insights into the evolution of sialic acid catabolism among bacteria
Almagro-Moreno, BMC evolutionary biology 2009 - “.... Challis substr. CH1 SAT 2 SGO_0122 1.00E-130 Streptococcus pneumoniae TIGR4 a SAT 2/3 SP_1688 SP_1682 3.00E-131 Streptococcus pneumoniae TIGR4 b Sym SP_1328 8.00E-59 Streptococcus pyogenes M1 GAS SAT 3 Spy_254 seed Streptococcus sanguinis SK36 SAT 2 SSA_0076 seed Vibrio cholerae N16961 TRAP VC1777 seed Vibrio...”
SPy1301 maltodextrin transport system permease from Streptococcus pyogenes M1 GAS
25% identity, 55% coverage
BL0261 sugar transport system permease protein from Bifidobacterium longum NCC2705
26% identity, 96% coverage
For advice on how to use these tools together, see
Interactive tools for functional annotation of bacterial genomes.
The PaperBLAST database links 793,807 different protein sequences to 1,259,118 scientific articles. Searches against EuropePMC were last performed on March 13 2025.
PaperBLAST builds a database of protein sequences that are linked
to scientific articles. These links come from automated text searches
against the articles in EuropePMC
and from manually-curated information from GeneRIF, UniProtKB/Swiss-Prot,
BRENDA,
CAZy (as made available by dbCAN),
BioLiP,
CharProtDB,
MetaCyc,
EcoCyc,
TCDB,
REBASE,
the Fitness Browser,
and a subset of the European Nucleotide Archive with the /experiment tag.
Given this database and a protein sequence query,
PaperBLAST uses protein-protein BLAST
to find similar sequences with E < 0.001.
To build the database, we query EuropePMC with locus tags, with RefSeq protein
identifiers, and with UniProt
accessions. We obtain the locus tags from RefSeq or from MicrobesOnline. We use
queries of the form "locus_tag AND genus_name" to try to ensure that
the paper is actually discussing that gene. Because EuropePMC indexes
most recent biomedical papers, even if they are not open access, some
of the links may be to papers that you cannot read or that our
computers cannot read. We query each of these identifiers that
appears in the open access part of EuropePMC, as well as every locus
tag that appears in the 500 most-referenced genomes, so that a gene
may appear in the PaperBLAST results even though none of the papers
that mention it are open access. We also incorporate text-mined links
from EuropePMC that link open access articles to UniProt or RefSeq
identifiers. (This yields some additional links because EuropePMC
uses different heuristics for their text mining than we do.)
For every article that mentions a locus tag, a RefSeq protein
identifier, or a UniProt accession, we try to select one or two
snippets of text that refer to the protein. If we cannot get access to
the full text, we try to select a snippet from the abstract, but
unfortunately, unique identifiers such as locus tags are rarely
provided in abstracts.
PaperBLAST also incorporates manually-curated protein functions:
- Proteins from NCBI's RefSeq are included if a
GeneRIF
entry links the gene to an article in
PubMed®.
GeneRIF also provides a short summary of the article's claim about the
protein, which is shown instead of a snippet.
- Proteins from Swiss-Prot (the curated part of UniProt)
are included if the curators
identified experimental evidence for the protein's function (evidence
code ECO:0000269). For these proteins, the fields of the Swiss-Prot entry that
describe the protein's function are shown (with bold headings).
- Proteins from BRENDA,
a curated database of enzymes, are included if they are linked to a paper in PubMed
and their full sequence is known.
- Every protein from the non-redundant subset of
BioLiP,
a database
of ligand-binding sites and catalytic residues in protein structures, is included. Since BioLiP itself
does not include descriptions of the proteins, those are taken from the
Protein Data Bank.
Descriptions from PDB rely on the original submitter of the
structure and cannot be updated by others, so they may be less reliable.
(For SitesBLAST and Sites on a Tree, we use a larger subset of BioLiP so that every
ligand is represented among a group of structures with similar sequences, but for
PaperBLAST, we use the non-redundant set provided by BioLiP.)
- Every protein from EcoCyc, a curated
database of the proteins in Escherichia coli K-12, is included, regardless
of whether they are characterized or not.
- Proteins from the MetaCyc metabolic pathway database
are included if they are linked to a paper in PubMed and their full sequence is known.
- Proteins from the Transport Classification Database (TCDB)
are included if they have known substrate(s), have reference(s),
and are not described as uncharacterized or putative.
(Some of the references are not visible on the PaperBLAST web site.)
- Every protein from CharProtDB,
a database of experimentally characterized protein annotations, is included.
- Proteins from the CAZy database of carbohydrate-active enzymes
are included if they are associated with an Enzyme Classification number.
Even though CAZy does not provide links from individual protein sequences to papers,
these should all be experimentally-characterized proteins.
- Proteins from the REBASE database
of restriction enzymes are included if they have known specificity.
- Every protein with an evidence-based reannotation (based on mutant phenotypes)
in the Fitness Browser is included.
- Sequence-specific transcription factors (including sigma factors and DNA-binding response regulators)
with experimentally-determined DNA binding sites from the
PRODORIC database of gene regulation in prokaryotes.
- Putative transcription factors from RegPrecise
that have manually-curated predictions for their binding sites. These predictions are based on
conserved putative regulatory sites across genomes that contain similar transcription factors,
so PaperBLAST clusters the TFs at 70% identity and retains just one member of each cluster.
- Coding sequence (CDS) features from the
European Nucleotide Archive (ENA)
are included if the /experiment tag is set (implying that there is experimental evidence for the annotation),
the nucleotide entry links to paper(s) in PubMed,
and the nucleotide entry is from the STD data class
(implying that these are targeted annotated sequences, not from shotgun sequencing).
Also, to filter out genes whose transcription or translation was detected, but whose function
was not studied, nucleotide entries or papers with more than 25 such proteins are excluded.
Descriptions from ENA rely on the original submitter of the
sequence and cannot be updated by others, so they may be less reliable.
Except for GeneRIF and ENA,
the curated entries include a short curated
description of the protein's function.
For entries from BioLiP, the protein's function may not be known beyond binding to the ligand.
Many of these entries also link to articles in PubMed.
For more information see the
PaperBLAST paper (mSystems 2017)
or the code.
You can download PaperBLAST's database here.
Changes to PaperBLAST since the paper was written:
- November 2023: incorporated PRODORIC and RegPrecise. Many PRODORIC entries were not linked to a protein sequence (no UniProt identifier), so we added this information.
- February 2023: BioLiP changed their download format. PaperBLAST now includes their non-redundant subset. SitesBLAST and Sites on a Tree use a larger non-redundant subset that ensures that every ligand is represented within each cluster. This should ensure that every binding site is represented.
- June 2022: incorporated some coding sequences from ENA with the /experiment tag.
- March 2022: incorporated BioLiP.
- April 2020: incorporated TCDB.
- April 2019: EuropePMC now returns table entries in their search results. This has expanded PaperBLAST's database, but most of the new entries are of low relevance, and the resulting snippets are often just lists of locus tags with annotations.
- February 2018: the alignment page reports the conservation of the hit's functional sites (if available from from Swiss-Prot or UniProt)
- January 2018: incorporated BRENDA.
- December 2017: incorporated MetaCyc, CharProtDB, CAZy, REBASE, and the reannotations from the Fitness Browser.
- September 2017: EuropePMC no longer returns some table entries in their search results. This has shrunk PaperBLAST's database, but has also reduced the number of low-relevance hits.
Many of these changes are described in Interactive tools for functional annotation of bacterial genomes.
PaperBLAST cannot provide snippets for many of the papers that are
published in non-open-access journals. This limitation applies even if
the paper is marked as "free" on the publisher's web site and is
available in PubmedCentral or EuropePMC. If a journal that you publish
in is marked as "secret," please consider publishing elsewhere.
Many important articles are missing from PaperBLAST, either because
the article's full text is not in EuropePMC (as for many older
articles), or because the paper does not mention a protein identifier such as a locus tag, or because of PaperBLAST's heuristics. If you notice an
article that characterizes a protein's function but is missing from
PaperBLAST, please notify the curators at UniProt
or add an entry to GeneRIF.
Entries in either of these databases will eventually be incorporated
into PaperBLAST. Note that to add an entry to UniProt, you will need
to find the UniProt identifier for the protein. If the protein is not
already in UniProt, you can ask them to create an entry. To add an
entry to GeneRIF, you will need an NCBI Gene identifier, but
unfortunately many prokaryotic proteins in RefSeq do not have
corresponding Gene identifers.
References
PaperBLAST: Text-mining papers for information about homologs.
M. N. Price and A. P. Arkin (2017). mSystems, 10.1128/mSystems.00039-17.
Europe PMC in 2017.
M. Levchenko et al (2017). Nucleic Acids Research, 10.1093/nar/gkx1005.
Gene indexing: characterization and analysis of NLM's GeneRIFs.
J. A. Mitchell et al (2003). AMIA Annu Symp Proc 2003:460-464.
UniProt: the universal protein knowledgebase.
The UniProt Consortium (2016). Nucleic Acids Research, 10.1093/nar/gkw1099.
BRENDA in 2017: new perspectives and new tools in BRENDA.
S. Placzek et al (2017). Nucleic Acids Research, 10.1093/nar/gkw952.
The EcoCyc database: reflecting new knowledge about Escherichia coli K-12.
I. M. Keeseler et al (2016). Nucleic Acids Research, 10.1093/nar/gkw1003.
The MetaCyc database of metabolic pathways and enzymes.
R. Caspi et al (2018). Nucleic Acids Research, 10.1093/nar/gkx935.
CharProtDB: a database of experimentally characterized protein annotations.
R. Madupu et al (2012). Nucleic Acids Research, 10.1093/nar/gkr1133.
The carbohydrate-active enzymes database (CAZy) in 2013.
V. Lombard et al (2014). Nucleic Acids Research, 10.1093/nar/gkt1178.
The Transporter Classification Database (TCDB): recent advances
M. H. Saier, Jr. et al (2016). Nucleic Acids Research, 10.1093/nar/gkv1103.
REBASE - a database for DNA restriction and modification: enzymes, genes and genomes.
R. J. Roberts et al (2015). Nucleic Acids Research, 10.1093/nar/gku1046.
Deep annotation of protein function across diverse bacteria from mutant phenotypes.
M. N. Price et al (2016). bioRxiv, 10.1101/072470.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory