PaperBLAST
PaperBLAST Hits for reanno::psRCH2:GFF2392 isobutyryl-CoA dehydrogenase (EC 1.3.8.5) (Pseudomonas stutzeri RCH2) (383 a.a., MHDLELSEDQ...)
Show query sequence
>reanno::psRCH2:GFF2392 isobutyryl-CoA dehydrogenase (EC 1.3.8.5) (Pseudomonas stutzeri RCH2)
MHDLELSEDQRMIRDMARDFARREIAPHAQAWEKAGWIDDTLVAQMGELGLLGMVVPEEW
GGSYIDYVAYALAVEEISAGDGATGALMSIHNSVGCGPVLNYGSQAQKDEWLTELASGRA
IGCFALTEPQAGSEAHNLRTRAELVDGHWVLNGSKQFCSNAKRSKLAIVFAVTDPELGKK
GLSAFLVPTDTPGFAVERSEHKMGIRASDTCGVSLSDCRIPEANLLGERGKGLAIALSNL
EGGRIGIGAQALGIARAAFEAALLYARERVQFGKPIAEHQSIANMLADMQTQLNAARLLI
LHAARLKSAGLPCLSEASQAKLFASEMAEKVCSQAVQIHGGYGYLEDYPVERYYRDARIT
QIYEGSSEIQRLLIARELANYAL
Running BLASTp...
Found 250 similar proteins in the literature:
Psest_2440 isobutyryl-CoA dehydrogenase (EC 1.3.8.5) from Pseudomonas stutzeri RCH2
100% identity, 100% coverage
- mutant phenotype: Important for valine utilization as N source, and isobutyryl-CoA is an intermediate in valine catabolism. SEED annotated it as butyryl-CoA dehydrogenase, which is also expected to perform this reaction
AO353_25670 isobutyryl-CoA dehydrogenase (EC 1.3.8.5) from Pseudomonas fluorescens FW300-N2E3
87% identity, 99% coverage
- mutant phenotype: Specifically important for: L-Valine. SEED has it as butyryl-CoA dehydrogenase, which is also expected to perform this reaction in valine catabolism
PP_3492 isobutyryl-CoA dehydrogenase (EC 1.3.8.5) from Pseudomonas putida KT2440
84% identity, 100% coverage
- mutant phenotype: Specific phenotype: utilization of L-Valine (mild phenotype, but confirmed by conservation)
PfGW456L13_2985 isobutyryl-CoA dehydrogenase (EC 1.3.8.5) from Pseudomonas fluorescens GW456-L13
85% identity, 100% coverage
- mutant phenotype: Specifically important for: L-Valine. Isobutyryl-CoA is an intermediate in valine degradation. SEED annotates it as butyryl-CoA dehydrogenase, which is also expected to perform this reaction
PS417_13840 isobutyryl-CoA dehydrogenase (EC 1.3.8.5) from Pseudomonas simiae WCS417
85% identity, 100% coverage
- mutant phenotype: Specifically important for: L-Valine. SEED annotates it as butyryl-CoA dehydrogenase, which is also expected to perform this reaction in valine catabolism
PNUC_RS08115 acyl-CoA dehydrogenase family protein from Polynucleobacter asymbioticus QLW-P1DMWA-1
77% identity, 99% coverage
AK34_3562 acyl-CoA dehydrogenase family protein from Burkholderia dolosa AU0158
72% identity, 97% coverage
Bcep1808_3337 acyl-CoA dehydrogenase domain-containing protein from Burkholderia vietnamiensis G4
A4JJ73 Acyl-CoA dehydrogenase domain protein from Burkholderia vietnamiensis (strain G4 / LMG 22486)
72% identity, 97% coverage
- Differential Expression and PAH Degradation: What Burkholderia vietnamiensis G4 Can Tell Us?
Cauduro, International journal of microbiology 2020 - “...Ma et al. [ 60 ]. These genes belong to the dehydrogenase groups: Acyl-CoA dehydrogenase (Bcep1808_3337), aldehyde dehydrogenase (Bcep1808_6786), methylmalonate-semialdehyde dehydrogenase (Bcep1808_3335), and trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase (Bcep1808_0122). Proline is directly related to the presence of a stressing agent, in the case of benzo(a)pyrene, and...”
- “...A4JQ98 Bcep1808_5507 63088..64278(+) 1191 Acetyl-CoA acetyltransferase Yes A4JK60 Bcep1808_3678 423951..426545(-) 2595 Aconitate hydratase Yes A4JJ73 Bcep1808_3337 29534..30667() 1134 Acyl-CoA dehydrogenase Yes A4JTS0 Bcep1808_6786 182448..183836() 1389 Aldehyde dehydrogenase Yes A4JKD6 Bcep1808_3756 501291..502235(+) 945 aldo/keto reductase Yes A4JJ72 Bcep1808_3336 27598..29310(-) 1713 AMP-dependent synthetase/ligase Yes A4JQ96 Bcep1808_5505 60596..62263(+) 1668...”
- Differential Expression and PAH Degradation: What Burkholderia vietnamiensis G4 Can Tell Us?
Cauduro, International journal of microbiology 2020 - “...Yes A4JQ98 Bcep1808_5507 63088..64278(+) 1191 Acetyl-CoA acetyltransferase Yes A4JK60 Bcep1808_3678 423951..426545(-) 2595 Aconitate hydratase Yes A4JJ73 Bcep1808_3337 29534..30667() 1134 Acyl-CoA dehydrogenase Yes A4JTS0 Bcep1808_6786 182448..183836() 1389 Aldehyde dehydrogenase Yes A4JKD6 Bcep1808_3756 501291..502235(+) 945 aldo/keto reductase Yes A4JJ72 Bcep1808_3336 27598..29310(-) 1713 AMP-dependent synthetase/ligase Yes A4JQ96 Bcep1808_5505 60596..62263(+)...”
4n5fA / B4EGC8 Crystal structure of a putative acyl-coa dehydrogenase with bound fadh2 from burkholderia cenocepacia j2315
71% identity, 97% coverage
- Ligand: dihydroflavine-adenine dinucleotide (4n5fA)
BCAM2196 putative acyl-CoA dehydrogenase from Burkholderia cenocepacia J2315
71% identity, 97% coverage
- Burkholderia cenocepacia differential gene expression during host-pathogen interactions and adaptation to the host environment
O'Grady, Frontiers in cellular and infection microbiology 2011 - “...BCAM2193 mmsB, 3-hydroxyisobutyrate dehydrogenase 2.4 BCAM2194 mmsA, methylmalonate-semialdehyde dehydrogenase 2.3 BCAM2195 Putative AMP-binding enzyme 2.5 BCAM2196 Putative acyl-CoA dehydrogenase 2.1 BCAM2237 Putative 2,2-dialkylglycine decarboxylase 2.4 BCAS0397 Metallo peptidase, subfamily M20D 2.0 BCAS0443 Putative binding-protein-dependent transport 5.3 BCAS0574 Amino acid ABC transporter ATP-binding protein 3.7 BCAS0575 Putative...”
- “...2.37 BCAM2193 Putative 3-hydroxyisobutyrate dehydrogenase 2.39 BCAM2194 Methylmalonate-semialdehyde dehydrogenase 2.26 BCAM2195 Putative AMP-binding enzyme 2.51 BCAM2196 Putative acyl-CoA dehydrogenase 2.10 BCAM2237 Putative 2,2-dialkylglycine decarboxylase 2.41 BCAM2260 Major facilitator superfamily protein 1.61 BCAM2338 Putative glycosyltransferase 1.53 BCAM2356 Conserved hypothetical protein 1.63 d BCAM2453 Putative redoxin protein 1.69...”
- Transcriptional responses of Burkholderia cenocepacia to polymyxin B in isogenic strains with diverse polymyxin B resistance phenotypes
Loutet, BMC genomics 2011 - “...5 Table S1). These genes include two clusters ( BCAL1212 to BCAL1215 and BCAM2191 to BCAM2196 ) that are overexpressed by 10-fold or more and are predicted to encode proteins involved in energy production and lipid metabolism. Genes down-regulated by 10-fold or more include one cluster...”
- “...to polymyxin B challenge. There are also genes ( BCAL1212 to BCAL1215 , BCAM2191 to BCAM2196 , BCAL1270 to BCAL1276 , and BCAL1083 ) whose expression is significantly altered in RSF34 4000B compared to RSF34 but are not altered between K56-2 and RSF34. These changes in...”
bglu_2g06260 Acyl-CoA dehydrogenase from Burkholderia glumae BGR1
72% identity, 98% coverage
- RNAseq-based Transcriptome Analysis of Burkholderia glumae Quorum Sensing
Kim, The plant pathology journal 2013 - “...primer (5-GGGGATG TGCTGCAAGGCG-3), which is internal sequence of pVIK112 vector. For pstA (bglu_1g11470) and fadE (bglu_2g06260) mutagenesis, we followed the same procedures as described in astC mutagenesis above. To insert the part of the pstA to pVIK112, EcoR I sequence was added to forward primer and...”
- “...and assayed mutant phenotypes were generated. Two mutants, astC -mutant-related arginine degradation II and fadE (bglu_2g06260) mutant, involved in fatty acid -oxidation I showed defects in swarming motility, whereas pstA mutant involved in phosphate transport did not show any phenotypes compared with wild type. The astC...”
A9762_23430 acyl-CoA dehydrogenase from Pandoraea sp. ISTKB
70% identity, 97% coverage
H16_B1192 Acyl-CoA dehydrogenase from Ralstonia eutropha H16
H16_B1192 acyl-CoA dehydrogenase family protein from Cupriavidus necator H16
69% identity, 99% coverage
- Insights into the Degradation of Medium-Chain-Length Dicarboxylic Acids in Cupriavidus necator H16 Reveal β-Oxidation Differences between Dicarboxylic Acids and Fatty Acids
Strittmatter, Applied and environmental microbiology 2022 (secret) - The genetic basis of 3-hydroxypropanoate metabolism in Cupriavidus necator H16
Arenas-López, Biotechnology for biofuels 2019 - “..., H16_B1190), -alanine pyruvate transaminase ( aptA , H16_A0272), branched-chain acyl-CoA dehydrogenase ( acaD , H16_B1192), enoyl-CoA dehydratase ( crt , H16_B1189) and 3-hydroxyisobutyryl-CoA hydrolase ( hibH ; note: the gene is currently annotated to encode an enoyl-CoA hydratase/isomerase, H16_B1188). Divergently transcribed transcriptional regulator genes encode...”
- “...transaminase responsible for the conversion of -alanine to malonate semialdehyde. A gene annotated as acaD (H16_B1192) encoding a putative acyl-CoA dehydrogenase is located immediately upstream of mmsA3 . Downstream of mmsA3 are the aforementioned hbdH (H16_B1190) and also putative genes annotated as encoding 3-hydroxybutyryl-CoA dehydratase (H16_B1189,...”
- Investigations on the microbial catabolism of the organic sulfur compounds TDP and DTDP in Ralstonia eutropha H16 employing DNA microarrays
Peplinski, Applied microbiology and biotechnology 2010 - “...mutase 248.35 2.87 7.00 x H16_A2251 phaY1 d -()-3-hydroxybutyrate oligomer hydrolase 3.07 3.79 9.93 x H16_B1192 Acyl-CoA dehydrogenase 25.89 77.24 2.92 x D Genes putatively involved in the uptake of DTDP H16_A2779 Probable extracytoplasmic solute receptor 5.46 4.13 2.63 x H16_A3718 Probable extracytoplasmic solute receptor 5.37...”
- “...4 ). The first group included four genes involved in fatty acid metabolism: H16_A0234 (threefold), H16_B1192 (3- to 77-fold) encoding acyl-CoA dehydrogenases and the 3-hydroxybutyrate oligomer hydrolase phaY1 (H16_A2251, three- to tenfold) (Table 1C ). The latter enzyme is known to be involved in the degradation...”
4m9aB / Q2T4A2 Crystal structure of acyl-coa dehydrogenase from burkholderia thailandensis e264
71% identity, 97% coverage
- Ligand: dihydroflavine-adenine dinucleotide (4m9aB)
BP1026B_II0681 acyl-CoA dehydrogenase family protein from Burkholderia pseudomallei 1026b
70% identity, 99% coverage
FQU82_00192 acyl-CoA dehydrogenase family protein from Acinetobacter baumannii
58% identity, 98% coverage
- Transcriptomic analysis reveals the regulatory role of quorum sensing in the Acinetobacter baumannii ATCC 19606 via RNA-seq
Xiong, BMC microbiology 2022 - “...found to be enriched in the propanoate metabolism: FQU82_00191, FQU82_00562, FQU82_03635, FQU82_01642 ( paaF ), FQU82_00192, FQU82_00189 ( mmsA ), FQU82_00193, FQU82_00159 ( prpB ), FQU82_00160 ( prpC ), and FQU82_00161 ( acnD ). In purine metabolism, 8 DEGs were downregulated, including FQU82_00576 ( ndk ),...”
BOV_RS12330 acyl-CoA dehydrogenase family protein from Brucella ovis ATCC 25840
60% identity, 97% coverage
- Mining the Flavoproteome of Brucella ovis, the Brucellosis Causing Agent in Ovis aries
Minjárez-Sáenz, Microbiology spectrum 2022 - “...(100) Acyl-CoA_dh_M (PF02770) 188-282 Acyl-CoA_dh_1 (PF00441) 292-447 54 1.3.8.- b Acyl-CoA dehydrogenase Acyl-CoA_dh_N (PF02771) 4-116 BOV_RS12330 ABQ62784.1 FAD 4N5F (63) Acyl-CoA_dh_M (PF02770) 120-214 Acyl-CoA_dh_1 (PF00441) 227-375 55 1.3.8.- b Acyl-CoA dehydrogenase Acyl-CoA_dh_N (PF02771) 9-115 BOV_RS14135 ABQ62889.1 FAD 5LNX (36) Acyl-CoA_dh_M (PF02770) 120-218 Acyl-CoA_dh_1 (PF00441) 231-378 56...”
PfGW456L13_2983 2-methylbutanoyl-CoA dehydrogenase (EC 1.3.8.5) from Pseudomonas fluorescens GW456-L13
58% identity, 97% coverage
- mutant phenotype: Specifically important for utilizing L-Isoleucine, which is oxidized via 2-methylbutanoyl-CoA
PP_2216 / Q88KS3 short-chain acyl-CoA dehydrogenase monomer (EC 1.3.8.1) from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see paper)
PP2216, PP_2216 acyl-CoA dehydrogenase family protein from Pseudomonas putida KT2440
58% identity, 97% coverage
- When metabolic prowess is too much of a good thing: how carbon catabolite repression and metabolic versatility impede production of esterified α,ω-diols in Pseudomonas putida KT2440
Lu, Biotechnology for biofuels 2021 - “...PP_2215), FadB : 3-hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase (PP_2047, PP_2136, PP_2214, PP_2217), FadE : acyl-CoA dehydrogenase (PP_2048, PP_2216) [ 36 , 37 ] of -oxidation were deleted, generating P. putida BOX as a control strain. For alkyl acetate ester hydrolysis in P. putida and esterase KO mutants, hexyl...”
- Fatty Acid and Alcohol Metabolism in Pseudomonas putida: Functional Analysis Using Random Barcode Transposon Sequencing
Thompson, Applied and environmental microbiology 2020 (secret) - Metabolic engineering of Pseudomonas putida for increased polyhydroxyalkanoate production from lignin
Salvachúa, Microbial biotechnology 2020 - “...is encoded at PP_2215. This putative operon also encodes an acylCoA dehydrogenase ( fadE ; PP_2216). These two gene clusters, PP_21362137 and PP_22142217, were deleted in strain AG2102, resulting in strain AG2228. Finally, to increase carbon flux from 3hydroxyacylACP to mcl PHAs, an additional, codonoptimized copy...”
- The protein coded by the PP2216 gene of Pseudomonas putida KT2440 is an acyl-CoA dehydrogenase that oxidises only short-chain aliphatic substrates
McMahon, FEMS microbiology letters 2005 (PubMed)- “...coded by the PP2216 gene of Pseudomonas putida KT2440 is an acyl-CoA dehydrogenase that oxidises only short-chain aliphatic substrates Brian McMahon, Mary E....”
- “...2005 Edited by H-P.E. Kohler Abstract A gene (PP2216) that codes for an acyl-CoA dehydrogenase was cloned from Pseudomonas putida strain KT2240 and...”
Psest_2445 2-methylbutanoyl-CoA dehydrogenase (EC 1.3.8.5) from Pseudomonas stutzeri RCH2
59% identity, 97% coverage
- mutant phenotype: Specifically important for: L-Isoleucine. SEED has it as butyryl-CoA dehydrogenase, which is also expected to perform this reaction. 2-methylbutanoyl-CoA is an intermediate in isoleucine catabolism
AO356_26355 2-methylbutanoyl-CoA dehydrogenase (EC 1.3.8.5) from Pseudomonas fluorescens FW300-N2C3
58% identity, 97% coverage
- mutant phenotype: Important for isoleucine utilization. 2-methylbutaonyl-CoA is an intermediate in the standard pathway and no other gene for the methylbutanoyl-CoA dehydrogenase was apparent in the fitness data.
BV82_1126 acyl-CoA dehydrogenase from Pseudomonas donghuensis
58% identity, 97% coverage
Pf6N2E2_1146 2-methylbutanoyl-CoA dehydrogenase (EC 1.3.8.5) from Pseudomonas fluorescens FW300-N2E2
58% identity, 97% coverage
- mutant phenotype: Specifically important for: L-Isoleucine. 2-methylbutanoyl-CoA is an intermediate in isoleucine catabolism.
PA2552 probable acyl-CoA dehydrogenase from Pseudomonas aeruginosa PAO1
59% identity, 97% coverage
- The development of a new parameter for tracking post-transcriptional regulation allows the detailed map of the Pseudomonas aeruginosa Crc regulon
Corona, Scientific reports 2018 - “...2,51 1,98 3,13 Catabolism gcvH2 PA2446 Glycine cleavage system protein H2 2,68 2,37 4,08 Catabolism PA2552 Probable acyl-CoA dehydrogenase 3,27 1,72 1,61 Catabolism PA2553 Probable acyl-CoA thiolase 4,09 2,36 2,63 Transport oprQ PA2760 OprQ 0,33 0,89 2,21 Catabolism pauB3 PA2776 FAD-dependent oxidoreductase 1,55 0,2 2,13 CCM/catabolism...”
- Within-Host Evolution of the Dutch High-Prevalent Pseudomonas aeruginosa Clone ST406 during Chronic Colonization of a Patient with Cystic Fibrosis
van, PloS one 2016 - “...PA2402 Secondary metabolites biosynthesis, transport and catabolism [ 13 ] 4794 GTC[V] > GCC[A] 80 PA2552 Lipid transport and metabolism [ 13 ] 2089 TAG[stop] >TGG[W] 51 PA4661 pagL no COG [ 13 ], [ 14 ] 4856 TTC[F] > TTG[L] 34 PA2492 b mexT Transcription...”
- Dissection of the cis-2-decenoic acid signaling network in Pseudomonas aeruginosa using microarray technique
Rahmani-Badi, Frontiers in microbiology 2015 - “...PA0493, PA0506-PA0508, PA0745-PA0746, PA0879, PA1020-PA1022, PA1187, PA1240, PA1470, PA1535, PA1576, PA1628-PA1629, PA1631, PA1827, PA1869, PA2550, PA2552, PA2815, PA2841, PA2887-PA2891, PA2893, PA3286, PA3426, PA3589, PA3591, PA3593, PA3924,PA4089, PA4330, PA4912, PA4979-PA4980, PA4995, PA5020, PA5524 Protein and Amino acid metabolism thrS, folC, glnA, gmk, tgt, dadA, pauA3A5, gltX, gcvT1T2,...”
- Pseudomonas aeruginosa twitching motility-mediated chemotaxis towards phospholipids and fatty acids: specificity and metabolic requirements
Miller, Journal of bacteriology 2008 - “...PA1736 PA1737 PA2011 PA2012 PA2013 PA2014 PA2015 PA2142 PA2552 PA2553 PA2554 PA2555 PA2557 PA2634 PA2764 PA2862 PA2863 PA2887 PA2888 PA2889 PA3013 PA3014 PA3267...”
- Effect of anaerobiosis and nitrate on gene expression in Pseudomonas aeruginosa
Filiatrault, Infection and immunity 2005 - “...PA2261 PA2264 PA2265 PA2302 PA2303 PA2366 PA2423 PA2478 PA2552 PA2553 PA2554 PA2555 PA2557 PA2572 PA2573 PA2753 PA2754 PA2759 PA2780 PA2790 PA3181 PA3329 PA3330...”
- “...California, Berkeley PA2443 PA2444 PA2445 PA2446 PA2460 PA2483 PA2552 PA2553 PA2554 PA2555 PA2570 PA2573 PA2593 PA2629 PA2663 PA2691 PA2763 PA2798 PA2968 PA2969...”
- A cystic fibrosis epidemic strain of Pseudomonas aeruginosa displays enhanced virulence and antimicrobial resistance
Salunkhe, Journal of bacteriology 2005 - “...PA2345 PA2365 PA2366 PA2367 PA2423 PA2433 PA2512 PA2513 PA2552 PA2553 PA2587 PA2588 PA2591 PA2592 Gene name GENE EXPRESSION IN A P. AERUGINOSA CF EPIDEMIC...”
- Microarray analysis of Pseudomonas aeruginosa quorum-sensing regulons: effects of growth phase and environment
Wagner, Journal of bacteriology 2003 - “...2017 by University of California, Berkeley PA2367 PA2423 PA2552 PA2553 PA2554 PA2555 PA2564 PA2565 PA2566 Change in PAO-JP2 (induced to uninduced) (fold)b...”
PS417_13850 2-methylbutanoyl-CoA dehydrogenase (EC 1.3.8.5) from Pseudomonas simiae WCS417
58% identity, 97% coverage
- mutant phenotype: Specifically important for: L-Isoleucine. SEED has it as butyryl-CoA dehydrogenase, which is also expected to perform this reaction in isoleucine catabolism
AO353_25680 2-methylbutanoyl-CoA dehydrogenase / butanoyl-CoA dehydrogenase / isobutyryl-CoA dehydrogenase (EC 1.3.8.1; EC 1.3.8.5) from Pseudomonas fluorescens FW300-N2E3
57% identity, 97% coverage
- mutant phenotype: Specifically important for: Sodium butyrate. SEED has it as butyryl-CoA dehydrogenase. Also important on isoleucine and valine, which implies that it acts on the other substrates as well
Pf1N1B4_4787 2-methylbutanoyl-CoA dehydrogenase (EC 1.3.8.5) from Pseudomonas fluorescens FW300-N1B4
56% identity, 97% coverage
- mutant phenotype: Important for isoleucine utilization. 2-methylbutaonyl-CoA is an intermediate in the standard pathway and no other gene for the methylbutanoyl-CoA dehydrogenase was apparent in the fitness data.
ABAYE1412 putative acyl-CoA dehydrogenase protein (acdB-like) from Acinetobacter baumannii AYE
55% identity, 98% coverage
A1S_0105 putative acyl-CoA dehydrogenase from Acinetobacter baumannii ATCC 17978
60% identity, 87% coverage
A1S_2149 putative acyl CoA dehydrogenase oxidoreductase protein from Acinetobacter baumannii ATCC 17978
59% identity, 86% coverage
BTF1_25115 acyl-CoA dehydrogenase from Bacillus thuringiensis HD-789
51% identity, 98% coverage
- NagRBt Is a Pleiotropic and Dual Transcriptional Regulator in Bacillus thuringiensis
Cao, Frontiers in microbiology 2018 - “...nucleotide metabolism might be on the same operon. The expression of genes, lipoprotein (BTF1_26870), acyl-dehydrogenase (BTF1_25115 and BTF1_08960), and acyl carrier protein (BTF1_17540) involved in fatty acid metabolism were decreased in the Bti75- nagR mutant, suggesting that NagR Bt could activate these genes, rather than repress...”
- “...0.188 0.6781 0.038 BTF1_24870 nuoC NADH dehydrogenase subunit C / / / 0.180 0.199 0.020 BTF1_25115 mmgC Acyl-CoA dehydrogenase / / / 0.172 NT BTF1_26870 Lipoprotein / / / 0.133 0.817 0.038 GENES WITH RECOGNIZED dre SITES BUT NOT DIFFERENTIALLY EXPRESSED IN nagR MUTANT COMPARED TO...”
Ac3H11_2996 2-methyl-branched-chain-enoyl-CoA reductase (EC 1.3.8.5) from Acidovorax sp. GW101-3H11
52% identity, 98% coverage
- mutant phenotype: Specifically important for utilizing L-Isoleucine. Automated validation from mutant phenotype: the predicted function (2-METHYLACYL-COA-DEHYDROGENASE-RXN) was linked to the condition via a SEED subsystem. A more specific reaction was selected manually.
HWX41_RS21030 acyl-CoA dehydrogenase AcdA from Bacillus paramycoides
51% identity, 99% coverage
- Genomic Analysis of Endophytic Bacillus cereus T4S and Its Plant Growth-Promoting Traits
Adeleke, Plants (Basel, Switzerland) 2021 - “...plant hormones. Pathway Gene Product Locus Tag ACC catabolism acd A acyl-CoA dehydrogenase Acd A HWX41_RS21030 Potassium transport kdp A potassium-transporting ATPase subunit A HWX41_RS15255 L-tryptophan production; IAA production ND tryptophan synthase subunit alpha HWX41_RS17780 trp B tryptophan synthase subunit beta HWX41_RS17785 trpC indole-3-glycerol phosphate synthase...”
ACDB_BACSU / P45857 Acyl-CoA dehydrogenase; EC 1.3.99.- from Bacillus subtilis (strain 168) (see paper)
51% identity, 98% coverage
- catalytic activity: a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2 (RHEA:48608)
cofactor: FAD
H16_A0172 Acyl-CoA dehydrogenase, short-chain specific from Ralstonia eutropha H16
52% identity, 98% coverage
BC5341 Acyl-CoA dehydrogenase, short-chain specific from Bacillus cereus ATCC 14579
51% identity, 99% coverage
mmgC / GI|1303933 acyl-CoA dehydrogenase from Bacillus subtilis (see paper)
51% identity, 98% coverage
RBIBE_22770 acyl-CoA dehydrogenase from Bacillus velezensis
50% identity, 98% coverage
- Complete genome sequence data of chitin-degrading Bacillus velezensis RB.IBE29
Tran, Data in brief 2023 - “...NarK RBIBE_34730 NADPH-nitrite reductase RBIBE_02980 Nitrite reductase small subunit NirD RBIBE_02970 ACC biosynthesis Acyl-CoA dehydrogenase RBIBE_22770 Acyl-CoA dehydrogenase RBIBE_18460 Acyl-CoA dehydrogenase FadE RBIBE_30110 Acyl-CoA dehydrogenase family protein RBIBE_04320 Acyl-CoA synthetase RBIBE_09970 Iron uptake and siderophore production Iron ABC transporter permease RBIBE_01700 Iron ABC transporter permease RBIBE_35840...”
5lnxD / P45857 Crystal structure of mmgc, an acyl-coa dehydrogenase from bacillus subtilis.
51% identity, 97% coverage
- Ligand: flavin-adenine dinucleotide (5lnxD)
ACDA_BACSU / P45867 Acyl-CoA dehydrogenase; EC 1.3.99.- from Bacillus subtilis (strain 168) (see paper)
acdA / GB|CAA89868.1 acyl-CoA dehydrogenase; EC 1.3.99.3 from Bacillus subtilis (see paper)
BSU37170 acyl-CoA dehydrogenase from Bacillus subtilis subsp. subtilis str. 168
51% identity, 99% coverage
Q1D5U4 Acyl-CoA dehydrogenase from Myxococcus xanthus (strain DK1622)
49% identity, 98% coverage
YP_354698 Acyl-CoA dehydrogenase from Rhodobacter sphaeroides 2.4.1
52% identity, 98% coverage
- A Chemo-Enzymatic Road Map to the Synthesis of CoA Esters
Peter, Molecules (Basel, Switzerland) 2016 - “...C and a final extension step for 5 min at 72 C. The butyryl-CoA dehydrogenase YP_354698 gene from Rhodobacter sphaeroides was amplified from chromosomal DNA by PCR using the forward primer GGATTT CATATG AGCGTCCTGACCGAC and the reverse primer GCATTT GGATCC TCACGCCA TGCCCCTGAG introducing a NdeI and...”
TTHE_RS08250 acyl-CoA dehydrogenase from Thermoanaerobacterium thermosaccharolyticum DSM 571
48% identity, 98% coverage
YP_147450 CoA dehydrogenase from Geobacillus kaustophilus HTA426
49% identity, 98% coverage
- Acyl-CoA dehydrogenases: Dynamic history of protein family evolution
Swigonová, Journal of molecular evolution 2009 - “...SCAD ( Fig. 6b ) in Acidobacteria bacterium (ABF41370), Bacillus cereus (NP_978856), and Geobacillus kaustophilus (YP_147450). With the exception of the active site catalytic residue position and the residue equivalent to human IVD Y371, which is distant in the active site, other residues are the same...”
ACADS_RAT / P15651 Short-chain specific acyl-CoA dehydrogenase, mitochondrial; SCAD; Butyryl-CoA dehydrogenase; EC 1.3.8.1 from Rattus norvegicus (Rat) (see 2 papers)
P15651 short-chain acyl-CoA dehydrogenase (EC 1.3.8.1) from Rattus norvegicus (see 2 papers)
50% identity, 92% coverage
- function: Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats (PubMed:3968063). The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl- CoA (PubMed:3968063). Among the different mitochondrial acyl-CoA dehydrogenases, short-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 4 to 6 carbons long primary chains (PubMed:3968063).
catalytic activity: a short-chain 2,3-saturated fatty acyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = a short-chain (2E)-enoyl- CoA + reduced [electron-transfer flavoprotein] (RHEA:47196)
catalytic activity: butanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein] (RHEA:24004)
catalytic activity: pentanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-pentenoyl-CoA + reduced [electron-transfer flavoprotein] (RHEA:43456)
catalytic activity: hexanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein] (RHEA:43464)
cofactor: FAD (Binds 1 FAD per subunit.)
subunit: Homotetramer. - Myocardial proteomic profile in pulmonary arterial hypertension.
Hołda, Scientific reports 2020 - “...subunit beta, mitochondrial 1.06 P00564 Ckm Creatine kinase M-type 1.08 P04797 Gapdh Glyceraldehyde-3-phosphate dehydrogenase 1.09 P15651 Acads Short-chain specific acyl-CoA dehydrogenase, mitochondrial 1.10 P21396 Maoa Amine oxidase [flavin-containing] A 1.13 P12075 Cox5b Cytochrome c oxidase subunit 5B, mitochondrial 1.13 P05545 Serpina3k Serine protease inhibitor A3K 1.15...”
- Leucine-Rich Diet Modulates the Metabolomic and Proteomic Profile of Skeletal Muscle during Cancer Cachexia.
Cruz, Cancers 2020 - “...W P49432 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial GN = Pdhb >5 WL W P15651 Short-chain specific acyl-CoA dehydrogenase, mitochondrial GN = Acads 1.174 WL W P48721 Stress-70 protein, mitochondrial GN = Hspa9 >5 WL W Q920L2 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial GN =...”
- Inflammation and apoptosis accelerate progression to irreversible atrophy in denervated intrinsic muscles of the hand compared with biceps: proteomic analysis of a rat model of obstetric brachial plexus palsy.
Yu, Neural regeneration research 2020 - “...acid metabolism 18 O35547 * , Q63151 * , P70584, Q9WVK3, P33124, G3V9U2, P14604, P17764, P15651, Q64428, Q5M9H2, Q9WVK7, Q60587, P18163, P18886, P08503, P07896, G3V7N5 < 0.001 Calcium signaling 16 P11275, P20651, A0A0G2K9C8, P13286, Q64578, A0A0G2JSR0, F1LLZ7, Q304F3, G3V731, A0A0G2K5J1, F1LQL1, P29117, Q9Z2L0, Q05962, Q62711, D3ZB81...”
- Nitric Oxide Donor NOC-18-Induced Changes of Mitochondrial Phosphoproteome in Rat Cardiac Ischemia Model.
Umbrasas, Medicina (Kaunas, Lithuania) 2019 - “...alpha somatic form mitochondrial (PDHA1) P26284 1.55 0.024 Short chain specific acyl CoAdehydrogenase mitochondrial (ACADS) P15651 1.58 0.027 Long chain specific acyl CoAdehydrogenase mitochondrial (ACADVL) P15650 1.59 0.027 Isovaleryl CoA dehydrogenase mitochondrial (IVD) P12007 1.59 0.030 Succinyl CoA ligase ADP GDP forming subunit alpha mitochondrial (SUCLG1)...”
- Functional proteomic analysis of corticosteroid pharmacodynamics in rat liver: Relationship to hepatic stress, signaling, energy regulation, and drug metabolism.
Ayyar, Journal of proteomics 2017 - “...mitochondrial Fatty acid beta oxidation - greatest activity toward short branched chain acyl-CoA derivatives UP/DOWN P15651 Acads Short-chain specific acyl-CoA dehydrogenase (SCAD) Fatty acid beta oxidation - catalyze the initial step of mitochondrial beta-oxidation of straight-chain fatty acid UP/DOWN Q5PPL3 Nsdhl Sterol-4-alpha-carboxylate 3-dehydrogenase Cholesterol biosynthesis UP...”
- Methylene blue decreases mitochondrial lysine acetylation in the diabetic heart.
Berthiaume, Molecular and cellular biochemistry 2017 - “...specific acyl-CoA dehydrogenase (MCAD) P08503 K.VPAS K AFTGFIVEADTPGIHIGK.K 217 0.87 Short-chain specific acyl-CoA dehydrogenase (SCAD) P15651 R.HAFGAPLT K LQNIQFK.L 306 0.31 Trifunctional enzyme subunit alpha (HADHa) Q64428 K.DTTASAVAVGL K QGK.V 531 0.21 K.TS K DTTASAVAVGLK.Q 519 0.14 R.DSIFSNLIGQLDY K GFEK.A 436 0.47 R.FVDLYGAQ K VVDR.L 728...”
- Proteomic Expression Changes in Large Cerebral Arteries After Experimental Subarachnoid Hemorrhage in Rat Are Regulated by the MEK-ERK1/2 Pathway.
Müller, Journal of molecular neuroscience : MN 2017 - “...O-fucosyltransferase 2 0.92 P61983 14-3-3 protein gamma 0.91 P28661 Septin-4 0.89 P14046 Alpha-1-inhibitor 3 0.88 P15651 Short-chain specific acyl-CoA dehydrogenase, mitochondrial 0.87 P19804 Nucleoside diphosphate kinase B 0.86 P85972 Vinculin 0.85 P15865 Histone H1.2 0.84 Q58FK9 Kynurenine--oxoglutarate transaminase 3 0.84 P62260 14-3-3 protein epsilon 0.84 Q5XI78...”
- Prediction of FAD binding sites in electron transport proteins according to efficient radial basis function networks and significant amino acid pairs.
Le, BMC bioinformatics 2016 - “...O54050 P41367 P97275 Q7WZ62 D0VWY5 O60341 P45954 Q2GBV9 Q7X2H8 O52582 P0A6U3 P47989 Q389T8 Q7ZA32 Q9RSY7 P15651 P49748 Q47PU3 Q8DMN3 Q9UBK8 P19920 P55789 Q52437 Q8X1D8 Q9UKU7 P07872 P09622 Q9HJI4 Q9HKS9 Q9HTK9 Sequence information Sequence information is one of the first features set in predicting the secondary structure...”
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Q6IMX3 short-chain acyl-CoA dehydrogenase from Rattus norvegicus
NP_071957 short-chain specific acyl-CoA dehydrogenase, mitochondrial precursor from Rattus norvegicus
50% identity, 91% coverage
- The mitochondrial proteomic changes of rat hippocampus induced by 28-day simulated microgravity.
Ji, PloS one 2022 - “...Peroxiredoxin 3 1.67 0.003211 F1LNF7_RAT F1LNF7 Idh3a Isocitrate dehydrogenase [NAD] subunit, mitochondrial 1.67 0.005636 Q6IMX3_RAT Q6IMX3 Acads Acetyl-Coenzyme A dehydrogenase, short chain, isoform CRA_a 1.67 0.01089 A0A0G2JVM0_RAT A0A0G2JVM0 Aldh4a1 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.66 0.007541 D4A8N2_RAT D4A8N2 Fdx2 Ferredoxin 2 1.66 0.0146 A0A0G2JZA2_RAT A0A0G2JZA2 Grpel1 GrpE protein...”
- Comparative proteomic analysis of the aging soleus and extensor digitorum longus rat muscles using TMT labeling and mass spectrometry
Chaves, Journal of proteome research 2013 - “...soleus muscles Protein accession no. P value Log 2 fold change a DESCRIPTION Energy metabolism Q6IMX3 0.017 0.8 Acetyl-Coenzyme A dehydrogenase, short chain, isoform CRA_a P13221 < 0.001 0.8 Aspartate aminotransferase, cytoplasmic P13221 0.001 1.1 Aspartate aminotransferase, mitochondrial F1LP05 < 0.001 0.9 ATP synthase subunit alpha...”
- Mechanism of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy)-mediated mitochondrial dysfunction in rat liver.
Moon, Proteomics 2008 - “...2 10 3-Ketoacyl-CoA thiolase P13437 7 Methylmalonate-semialdehyde dehydrogenase (ALDH6) Q02253 6 Acetyl-CoA dehydrogenase, short chain Q6IMX3 3 Glutamate dehydrogenase 1 (GDH) P10860 2 Long-chain specific acyl-CoA dehydrogenase P15650 2 11 3-Ketoacyl-CoA thiolase P13437 12 Methylmalonate-semialdehyde dehydrogenase (ALDH6) Q02253 8 Glutamate dehydrogenase 1 (GDH) P10860 4 Fumarate...”
- “...P13437 1 13 Probable oxidoreductase Q68FT3 4 3-Ketoacyl-CoA thiolase P13437 3 Acetyl-CoA dehydrogenase, short chain Q6IMX3 3 Protein disulfide-isomerase A6 precursor Q63081 3 3-Ketoacyl-CoA thiolase A, peroxisomal P21775 2 Peroxisomal delta3, delta2-enoyl-CoA isomerase Q5XIC0 2 14 Acetyl-CoA dehydrogenase, short chain Q6IMX3 4 3-Ketoacyl-CoA thiolase P13437 3...”
- Short-chain acyl-CoA dehydrogenase is a potential target for the treatment of vascular remodelling.
Zhong, Journal of hypertension 2023 (PubMed)- GeneRIF: Short-chain acyl-CoA dehydrogenase is a potential target for the treatment of vascular remodelling.
- Effects of short-chain acyl-CoA dehydrogenase on cardiomyocyte apoptosis.
Zeng, Journal of cellular and molecular medicine 2016 - GeneRIF: the role of SCAD in tert-butyl hydroperoxide (tBHP)-induced cardiomyocyte apoptosis, is reported.
- Effects of ERK1/2/PPARα/SCAD signal pathways on cardiomyocyte hypertrophy induced by insulin-like growth factor 1 and phenylephrine.
Huang, Life sciences 2015 (PubMed)- GeneRIF: the phosphorylation of ERK1/2 inhibited the expression and activity of SCAD through the PPARalpha signaling pathway, which induced the development of pathological cardiomyocyte hypertrophy.
- Changes in short-chain acyl-coA dehydrogenase during rat cardiac development and stress.
Huang, Journal of cellular and molecular medicine 2015 - GeneRIF: the down-regulated expression of SCAD in pathological cardiac hypertrophy may be responsible for 'the recapitulation of foetal energy metabolism'.
- Crystal structure of rat short chain acyl-CoA dehydrogenase complexed with acetoacetyl-CoA: comparison with other acyl-CoA dehydrogenases.
Battaile, The Journal of biological chemistry 2002 (PubMed)- GeneRIF: Crystal structure of rat short chain acyl-CoA dehydrogenase complexed with acetoacetyl-CoA: comparison with other acyl-CoA dehydrogenases.
DSY1718 hypothetical protein from Desulfitobacterium hafniense Y51
50% identity, 97% coverage
NP_031409 short-chain specific acyl-CoA dehydrogenase, mitochondrial precursor from Mus musculus
Q07417 Short-chain specific acyl-CoA dehydrogenase, mitochondrial from Mus musculus
49% identity, 92% coverage
- Aging-induced short-chain acyl-CoA dehydrogenase promotes age-related hepatic steatosis by suppressing lipophagy.
Deng, Aging cell 2024 - GeneRIF: Aging-induced short-chain acyl-CoA dehydrogenase promotes age-related hepatic steatosis by suppressing lipophagy.
- Brain transcriptional responses to high-fat diet in Acads-deficient mice reveal energy sensing pathways.
Kruger, PloS one 2012 - GeneRIF: Results suggest that the decreased beta-oxidation of short-chain fatty acids in Acads-deficient mice fed HF diet produces a state of energy deficiency in the brain.
- Brown adipose tissue function in short-chain acyl-CoA dehydrogenase deficient mice.
Skilling, Biochemical and biophysical research communications 2010 - GeneRIF: These results suggest that reduced brown adipose tissue function is not the major factor causing cold sensitivity in acyl-CoA dehydrogenase knockout strains.
- Mice bearing Acads mutation display altered postingestive but not 5-s orosensory response to dietary fat.
Smith, American journal of physiology. Regulatory, integrative and comparative physiology 2004 (PubMed)- GeneRIF: SCAD-deficient mice display altered postingestive responses to dietary fat, providing further evidence for metabolic control of feeding. Acads does not alter acute orosensory response to this fat stimulus.
- Misfolding, degradation, and aggregation of variant proteins. The molecular pathogenesis of short chain acyl-CoA dehydrogenase (SCAD) deficiency.
Pedersen, The Journal of biological chemistry 2003 (PubMed)- GeneRIF: some variants of SCAD proteins (R22W, G68C, W153R, and R359C) are severely misfolded, which may implicate a role in the pathogenesis of SCAD deficiency
- Branched-Chain Amino Acid Degradation Pathway was Inactivated in Colorectal Cancer: Results from a Proteomics Study
Lian, Journal of Cancer 2024 - “...0.65 Yes P54869 Hmgcs2 Hydroxymethylglutaryl-CoA synthase, mitochondrial 27.17 20 1.01 0.32 0.28 Down 0.016 Yes Q07417 Acads Short-chain specific acyl-CoA dehydrogenase, mitochondrial 19.42 7 1 0.46 0.45 Down 0.24 Yes Q61425 Hadh Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial 21.34 7 1.01 0.53 0.51 Down 0.25 Yes Q8BH95 Echs1...”
- A quantitative proteomic approach to evaluate the efficacy of carnosine in a murine model of chronic obstructive pulmonary disease (COPD).
D'Amato, Redox biology 2024 - “...Dcn 10 39,81 0,44 1,48 Q3UIJ9 Myocardial zonula adherens protein Myzap 11 53,90 0,48 1,51 Q07417 Short-chain specific acyl-CoA dehydrogenase, mitochondrial Acads 9 44,89 0,50 1,53 A0A0R4J139 Methionine-R-sulfoxide reductase B3, mitochondrial Msrb3 4 20,22 0,45 1,54 Q5SWZ5 Myosin phosphatase Rho-interacting protein Mprip 15 257,28 0,37 1,58...”
- Mitochondrial Sirtuin-3 (SIRT3) Prevents Doxorubicin-Induced Dilated Cardiomyopathy by Modulating Protein Acetylation and Oxidative Stress.
Tomczyk, Circulation. Heart failure 2022 - “...1.49 Aconitate hydratase Aco2 Q99KI0 AIIT k SFAR K689 1.33 Short-chain specific acyl-CoA dehydrogenase Acadsd Q07417 AAML k DNK K335 0.95 Malate dehydrogenase, cytoplasmic Mdh1 P14152 SQGTALE k YAK K118 0.69 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit Sdhb Q9CQA3 WDPD k TGDKPR K53 0.58 Trifunctional enzyme subunit...”
- The amyloid peptide β disrupts intercellular junctions and increases endothelial permeability in a NADPH oxidase 1-dependent manner.
Tarafdar, Redox biology 2022 - “...Mitochondrial import receptor subunit TOM20 homolog Tomm20 0.013691041 P51174 Long-chain specific acyl-CoA dehydrogenase Acadl 0.014069291 Q07417 Short-chain specific acyl-CoA dehydrogenase Acads 0.014588163 Q9JIY5 Serine protease HTRA2, mitochondrial Htra2 0.01537337 Q8BGX2 Mitochondrial import membrane translocase (Tim29) Timm29 0.017629493 Q9WVA2 Mitochondrial import membrane translocase (Tim8A) Timm8a1 0.020053563 Q9D7B6...”
- ISG15 Is a Novel Regulator of Lipid Metabolism during Vaccinia Virus Infection.
Albert, Microbiology spectrum 2022 - “...P97742 Cpt1a Carnitine O -palmitoyltransferase 1, liver isoform 8.54 Q8BH95 Echs1 Enoyl-CoA hydratase, mitochondrial 8.31 Q07417 Acads Short-chain-specific acyl-CoA dehydrogenase, mitochondrial 7.62 P51174 Acadl Long-chain-specific acyl-CoA dehydrogenase, mitochondrial 6.74 Q8QZT1 Acat1 Acetyl-CoA acetyltransferase, mitochondrial 6.14 P42125 Eci1 Enoyl-CoA delta isomerase 1, mitochondrial 6.00 Q9R0H0 Acox1 Peroxisomal...”
- Adipocyte-Derived Extracellular Vesicles: State of the Art.
Rome, International journal of molecular sciences 2021 - “...]. Gene Symbols Protein Accession Numbers Gene Names Acadl P51174 acyl-Coenzyme A dehydrogenase, long-chain Acads Q07417 acyl-Coenzyme A dehydrogenase, short chain Aco2 Q99KI0 aconitase 2, mitochondrial Acsl1 P41216 acyl-CoA synthetase long-chain family member 1 Adipoq Q60994 adiponectin, C1Q and collagen domain containing Agpat2 Q8K3K7 1-acylglycerol-3-phosphate O-acyltransferase...”
- PAX2 promotes epithelial ovarian cancer progression involving fatty acid metabolic reprogramming.
Feng, International journal of oncology 2020 - “...1 1.48 Up 0.0436 P50544 Acadvl Very long-chain specific acyl-CoA dehydrogenase, mitochondrial 1.48 Up 0.0435 Q07417 Acads Short-chain specific acyl-CoA dehydrogenase, mitochondrial 1.44 Up 0.0039 P45952 Acadm Medium-chain specific acyl-CoA dehydrogenase, mitochondrial 1.35 Up 0.0346 O08756 Hsd17b10 3-hydroxyacyl-CoA dehydrogenase type-2 1.27 Up 0.0096 Fatty acid activation...”
- Proteomic profiling of liver tissue from the mdx-4cv mouse model of Duchenne muscular dystrophy
Murphy, Clinical proteomics 2018 - “...short, branched, medium, long and very long chain specific acyl-CoA dehydrogenases (P51174, Q8K370, Q8JZN5, P45952, Q07417, P50544, Q9DBL1, Q80XL6) and 3-hydroxyacyl-CoA dehydrogenase (O08756), and (5) enzymes of ketone body metabolism, including the cytoplasmic HMGCS1 isoform (Q8JZK9) and mitochondrial HMGCS2 isoform (P54869) of hydroxyl-methylglutaryl-CoA synthase. Proteomic profiling...”
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7y0aC / P16219 Crystal structure of human short-chain acyl-coa dehydrogenase
50% identity, 97% coverage
- Ligand: flavin-adenine dinucleotide (7y0aC)
ACADS / P16219 short-chain acyl-CoA dehydrogenase monomer (EC 1.3.8.1) from Homo sapiens (see 11 papers)
ACADS_HUMAN / P16219 Short-chain specific acyl-CoA dehydrogenase, mitochondrial; SCAD; Butyryl-CoA dehydrogenase; EC 1.3.8.1 from Homo sapiens (Human) (see 4 papers)
NP_000008 short-chain specific acyl-CoA dehydrogenase, mitochondrial isoform 1 precursor from Homo sapiens
E5KSD5 short-chain acyl-CoA dehydrogenase from Homo sapiens
50% identity, 92% coverage
- function: Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats (By similarity). The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl- CoA (By similarity). Among the different mitochondrial acyl-CoA dehydrogenases, short-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 4 to 6 carbons long primary chains (PubMed:11134486, PubMed:21237683).
catalytic activity: a short-chain 2,3-saturated fatty acyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = a short-chain (2E)-enoyl- CoA + reduced [electron-transfer flavoprotein] (RHEA:47196)
catalytic activity: butanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein] (RHEA:24004)
catalytic activity: pentanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-pentenoyl-CoA + reduced [electron-transfer flavoprotein] (RHEA:43456)
catalytic activity: hexanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein] (RHEA:43464)
cofactor: FAD (Binds 1 FAD per subunit. {ECO:0000269|Ref.)10}
subunit: Homotetramer. - Short-chain acyl-CoA dehydrogenase is a potential target for the treatment of vascular remodelling.
Zhong, Journal of hypertension 2023 (PubMed)- GeneRIF: Short-chain acyl-CoA dehydrogenase is a potential target for the treatment of vascular remodelling.
- The minor C-allele of the rs2014355 variant in ACADS gene is associated with exercise-induced increase in HDL cholesterol levels in Taiwanese adults.
Yang, Medicine 2021 - GeneRIF: The minor C-allele of the rs2014355 variant in ACADS gene is associated with exercise-induced increase in HDL cholesterol levels in Taiwanese adults.
- Screening and follow-up results of fatty acid oxidative metabolism disorders in 608 818 newborns in Jining, Shandong province.
Yang, Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 2021 - GeneRIF: Screening and follow-up results of fatty acid oxidative metabolism disorders in 608 818 newborns in Jining, Shandong province.
- Integrated Analysis of Expression and Prognostic Values of Acyl-CoA Dehydrogenase short-chain in Colorectal Cancer.
Wu, International journal of medical sciences 2021 - GeneRIF: Integrated Analysis of Expression and Prognostic Values of Acyl-CoA Dehydrogenase short-chain in Colorectal Cancer.
- Effects of genetic variations in Acads gene on the risk of chronic obstructive pulmonary disease.
Yuan, IUBMB life 2020 (PubMed)- GeneRIF: Effects of genetic variations in Acads gene on the risk of chronic obstructive pulmonary disease.
- ACADS acts as a potential methylation biomarker associated with the proliferation and metastasis of hepatocellular carcinomas.
Chen, Aging 2019 - GeneRIF: ACADS acts as a potential methylation biomarker associated with the proliferation and metastasis of hepatocellular carcinomas.
- An unusually high frequency of SCAD deficiency caused by two pathogenic variants in the ACADS gene and its relationship to the ethnic structure in Slovakia.
Lisyová, BMC medical genetics 2018 - GeneRIF: Study discovered a high occurrence of two rare pathogenic variants-the deletion c.310_312delGAG and the substitution c.1138C>T, with allelic frequencies of 64% and 31%, respectively especially in the Roma ethnic group.
- Fluxomic evidence for impaired contribution of short-chain acyl-CoA dehydrogenase to mitochondrial palmitate β-oxidation in symptomatic patients with ACADS gene susceptibility variants.
Dessein, Clinica chimica acta; international journal of clinical chemistry 2017 (PubMed)- GeneRIF: a link between ACADS susceptibility variants and abnormal beta-oxidation consistent with known altered kinetics of these variants
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- Integrative analysis reveals marker genes for intestinal mucosa barrier repairing in clinical patients.
Zhao, iScience 2023 - “...12.85 1.96 Sulfurtransferase; Thiosulfate sulfurtransferase TST Q53EW8 14.02 1.00 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS E5KSD5 4.34E-08 Intestinal mucosal healing markers are associated with improved patients post-operational recovery outcomes To determine the clinical relevance of the 10 potential intestinal barrier repairing markers identified in the current...”
- Mining Autoimmune-Disorder-Linked Molecular-Mimicry Candidates in Clostridioides difficile and Prospects of Mimic-Based Vaccine Design: An In Silico Approach.
Alshamrani, Microorganisms 2023 - “...formyltransferase P31939 QWS55813.1 Q18A34 5 WQLVKELKEA SFKHVSPAGAAVG REVSDGIIAPGY KYTQSNSVCYAK GAGQQSRIHCTRLAG 0.73 1.23 20 Acyl-CoA dehydrogenase P16219 QWS55947.1 Q18AQ1 2 LIFEDCRIPK ITEIYEGTSE 0.72 0.99 21 Acetyl-CoA C-acetyltransferase Q9BWD1 QWS55952.1 Q18AR0 2 NASGINDGAA 0.70 0.75 22 Fe-S cluster assembly scaffold protein NifU Q9H1K1 QWS56138.1 Q18BE3 2 GCGSAIASSS 1.01...”
- “...Diabetes mellitus, Juvenile idiopathic arthritis - - - - C. neoformans [ 121 ] 18 P16219 Acyl-CoA dehydrogenase Allergic rhinitis, Ulcerative colitis, Crohns disease - - - - - 19 Q9BWD1 Acetyl-CoA C-acetyltransferase - - Parkinsons disease HBV, Viral carcinogenesis - - 20 Q9H1K1 Fe-S cluster...”
- Mitochondria-derived vesicles and their potential roles in kidney stone disease.
Chaiyarit, Journal of translational medicine 2023 - “...dehydrogenase/reductase 1) (retSDR1) (Retinol dehydrogenase 17) (Short chain dehydrogenase/reductase family 16C member 1) 204 ACADS P16219 Short-chain specific acyl-CoA dehydrogenase, mitochondrial (SCAD) (EC 1.3.8.1) (Butyryl-CoA dehydrogenase) 205 SLC6A13 Q9NSD5 Sodium- and chloride-dependent GABA transporter 2 (GAT-2) (Solute carrier family 6 member 13) 206 SPATA2L Q8IUW3 Spermatogenesis-associated...”
- Muscle Proteomic and Transcriptomic Profiling of Healthy Aging and Metabolic Syndrome in Men.
Gueugneau, International journal of molecular sciences 2021 - “...1486 P05413 FABP3 Fatty acid-binding protein, heart 0.001 1.45 1.29 737 64 23 9 1856 P16219 ACADS Short-chain specific acyl-CoA dehydrogenase, mitochondrial 0.040 1.29 325 25 19 8 839 Q13011 ECH1 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial 0.013 1.33 1.42 865 30 22 8 837 Q13011 ECH1 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase,...”
- Yersinia pseudotuberculosis YopJ Limits Macrophage Response by Downregulating COX-2-Mediated Biosynthesis of PGE2 in a MAPK/ERK-Dependent Manner.
Sheppe, Microbiology spectrum 2021 - “...factor 1 epsilon 1 O43324 0.004 3.333 Cytoplasm Translation regulator ACADS Acyl-CoA dehydrogenase short chain P16219 0.021 2.5 Cytoplasm Enzyme CAPRIN1 Cell cycle-associated protein 1 Q14444 0.013 2.5 Plasma membrane Other H1-10 H1.10 linker histone Q92522 0.043 2.5 Nucleus Other LUC7L3 LUC7 like 3 pre-mRNA splicing...”
- Electron transfer flavoprotein and its role in mitochondrial energy metabolism in health and disease.
Henriques, Gene 2021 - “...dehydrogenase ACADM P11310 Fatty acid oxidation C4- to C16-CoA SCAD Short-chain specific acyl-CoA dehydrogenase ACADS P16219 Fatty acid oxidation C4- to C6-CoA ACAD9 Complex I assembly factor ACAD9 ACAD9 Q9H845 Complex I assembly, fatty acid oxidation long-chain unsaturated acyl-CoAs ACAD10 Acyl-CoA dehydrogenase family member 10 ACAD10...”
- Identification of HO-1 as a novel biomarker for graft acute cellular rejection and prognosis prediction after liver transplantation
Jia, Annals of translational medicine 2020 - “...mitochondrial SDHB 0.740 P43155 Carnitine O-acetyltransferase CRAT 0.742 P10599 Isoform 2 of Thioredoxin TXN 0.746 P16219 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.748 Q9Y2Q3 Glutathione S-transferase kappa 1 GSTK1 0.749 Q9BUP3 Oxidoreductase HTATIP2 HTATIP2 0.749 P62266 40S ribosomal protein S23 RPS23 0.753 O75191 Xylulose kinase XYLB...”
- Discovery of Candidate Stool Biomarker Proteins for Biliary Atresia Using Proteome Analysis by Data-Independent Acquisition Mass Spectrometry.
Watanabe, Proteomes 2020 - “...disulfide-isomerase A6 PDIA6 6.8 Q9UJ70 N-acetyl-D-glucosamine kinase NAGK 6.3 O94788 Retinal dehydrogenase 2 ALDH1A2 6.2 P16219 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 6.1 O15143 Actin-related protein 2/3 complex subunit 1B ARPC1B 6.1 O95571 Persulfide dioxygenase ETHE1, mitochondrial ETHE1 5.9 P15531 Nucleoside diphosphate kinase A NME1 5.8...”
- Proteomic investigation of human skeletal muscle before and after 70 days of head down bed rest with or without exercise and testosterone countermeasures.
Dillon, PloS one 2019 - “...0.068 25.534 0.401 61.275 0.014 72.284 0.601 -11.301 metabolic Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS P16219 6.30 38 44 95 FRAG 0.119 -20.021 0.011 -47.653 0.624 -4.929 0.590 2.441 0.353 10.737 0.211 21.749 transport Hemoglobin subunit alpha HBA1 P69905 5.24 13 15 152 FRAG 0.836 4.416...”
- “...0.091 ###### 0.450 -62.068 0.122 -50.316 0.154 -53.174 metabolic Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS P16219 6.30 38 44 95 FRAG 0.417 -11.555 0.097 -22.539 0.323 9.613 0.631 2.673 0.602 7.540 0.620 -8.344 structural Keratin, type II cytoskeletal 6A KRT6A P02538 6.13 33 60 435 FRAG...”
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BSU18260 acyl-CoA dehydrogenase, short-chain specific from Bacillus subtilis subsp. subtilis str. 168
49% identity, 98% coverage
- The program of gene transcription for a single differentiating cell type during sporulation in Bacillus subtilis
Eichenberger, PLoS biology 2004 - “...ylbJ (BSU15030), ylbO/gerR (BSU15090), yngE (BSU18210), yngF (BSU18220), yngG (BSU18230), yngH (BSU18240), yngI (BSU18250), yngJ (BSU18260), yoaB (BSU18540), yoaD (BSU18560), yodU (BSU19810), ypqA (BSU22240), ypqP (BSU21670), yqfT (BSU25120), yqhV (BSU24440), yrdK (BSU26680), yydB (BSU40220), yydC (BSU40210), yydD (BSU40200), yydG (BSU40170), yydH (BSU40160), yydI (BSU40150), and yydJ...”
TTE0545 Acyl-CoA dehydrogenases from Thermoanaerobacter tengcongensis MB4
46% identity, 98% coverage
R0JG91 short-chain acyl-CoA dehydrogenase (Fragment) from Anas platyrhynchos
54% identity, 88% coverage
SE37_11180 acyl-CoA dehydrogenase from Geobacter soli
47% identity, 98% coverage
- Genome sequence of a dissimilatory Fe(III)-reducing bacterium Geobacter soli type strain GSS01(T)
Yang, Standards in genomic sciences 2015 - “...of G. soli : acyl-CoA dehydrogenase (SE37_11155, 80% similarity to Gmet_1710 in G. metallireducens ; SE37_11180, 86% similarity to that of Geoalkalibacter subterraneus ), succinyl-CoA:acetate CoA-transferases (SE37_00360; SE37_11235, 83% similarity to Gbem_2843 in G. bemidjiensis ; SE37_13685), acyl-CoA thioesterases (SE37_09325, SE37_09950, SE37_10860, SE37_14445 and SE37_15385), enoyl-CoA...”
U3J8W0 short-chain acyl-CoA dehydrogenase from Anas platyrhynchos platyrhynchos
54% identity, 88% coverage
- Dietary riboflavin supplementation improves meat quality, antioxidant capacity, fatty acid composition, lipidomic, volatilomic, and proteomic profiles of breast muscle in Pekin ducks
Tang, Food chemistry: X 2023 - “...acyl-CoA dehydrogenase ACADL 8.39 3.16E06 U3ITA9 Medium chain specific acyl-CoA dehydrogenase ACADM 9.28 6.71 E07 U3J8W0 Short chain acyl-CoA dehydrogenase ACADS 2.68 2.60 E03 U3I5L4 Long chain fatty acid CoA ligase 6 ACSL6 2.39 4.56 E07 U3IR48 Dihydrolipoyl dehydrogenase DLD 3.01 1.41 E03 R0K2W7 Glycerol-3-phosphate dehydrogenase...”
- Effect of riboflavin deficiency on intestinal morphology, jejunum mucosa proteomics, and cecal microbiota of Pekin ducks
Xu, Animal nutrition (Zhongguo xu mu shou yi xue hui) 2023 - “...dehydrogenase long chain ACADL 2.80 2.14E-07 U3ITA9 Medium-chain specific acyl-CoA dehydrogenase, mitochondrial ACADM 1.85 5.84E-04 U3J8W0 Acyl-CoA dehydrogenase short chain ACADS 2.08 2.18E-05 U3J1J0 Acyl-CoA dehydrogenase family member 9 ACAD9 2.42 1.00E-04 R0LSV8 Electron transfer flavoprotein-ubiquinone oxidoreductase ETFDH 2.31 3.88E-05 U3IM27 Aldedh domain-containing protein ALDH2 2.17...”
- Maternal diet deficient in riboflavin induces embryonic death associated with alterations in the hepatic proteome of duck embryos
Tang, Nutrition & metabolism 2019 - “...2.90 4.26E-04 U3J7F4 Electron transfer flavoprotein alpha subunit ETFA 62.87 17 17 2.69 1.46E-02 FAD U3J8W0 Acyl-CoA dehydrogenase short chain ACADS 49.30 14 14 2.36 4.32E-03 FAD U3IFB0 2,4-dienoyl-CoA reductase 1 DECR1 39.20 9 9 2.32 2.32E-02 U3I806 Trifunctional enzyme subunit alpha, mitochondrial HADHA 53.42 39...”
D4QEZ8 short-chain acyl-CoA dehydrogenase (EC 1.3.8.1) from Homo sapiens (see paper)
50% identity, 92% coverage
- HSP60 Regulates Lipid Metabolism in Human Ovarian Cancer
Li, Oxidative medicine and cellular longevity 2021 - “...sapiens GN=ACOX1 PE=3 SV=1[A0A024R8L7_HUMAN] ACOX1 29.85 14 14 23 74.64 7.62 1.53 3.40 E 02 D4QEZ8 Short-chain acyl-CoA dehydrogenase OS=Homo sapiens GN=ACADS PE=2 SV=1[D4QEZ8_HUMAN] ACADS 27.67 8 8 19 44.33 7.72 1.33 6.43 E 06 P45954 Short/branched chain-specific acyl-CoA dehydrogenase, mitochondrial OS=Homo sapiens GN=ACADSB PE=1 SV=1[ACDSB_HUMAN]...”
- “...sapiens GN=ACAA1 PE=1 SV=2[THIK_HUMAN] ACAA1 46.23 4 14 50 44.26 8.44 2.70 1.00 E 02 D4QEZ8 Short-chain acyl-CoA dehydrogenase OS=Homo sapiens GN=ACADS PE=2 SV=1[D4QEZ8_HUMAN] ACADS 27.67 8 8 19 44.33 7.72 1.33 6.43 E 06 P45954 Short/branched chain-specific acyl-CoA dehydrogenase, mitochondrial OS=Homo sapiens GN=ACADSB PE=1 SV=1[ACDSB_HUMAN]...”
- The Fatty Acid β-Oxidation Pathway is Activated by Leucine Deprivation in HepG2 Cells: A Comparative Proteomics Study
Yan, Scientific reports 2017 - “...5.621 P30038 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 5.152*|- 5.152 P00480 Ornithine carbamoyltransferase, mitochondrial OTC 4.747*|- 4.747 D4QEZ8 Short-chain acyl-CoA dehydrogenase ACADS 4.739*|- 4.739 Q9Y365 PCTP-like protein STARD10 4.659*|- 4.659 B2RBJ5 Alanine-glyoxylate aminotransferase 2 (AGXT2), nuclear gene encoding mitochondrial protein AGXT2 3.959*|- 3.959 P83111 Serine beta-lactamase-like protein LACTB,...”
- “...Ala, Asp and Glu metabolism P00480 Ornithine carbamoyltransferase, mitochondrial OTC 4.747* Arg and Pro metabolism D4QEZ8 Short-chain acyl-CoA dehydrogenase ACADS 4.739* Val, Leu and Ile degradation B2RBJ5 Alanine-glyoxylate aminotransferase 2 AGXT2 3.959* Gly, Ser and Thr metabolism; Ala, Asp and Glu metabolism P26440 Isovaleryl-CoA dehydrogenase, mitochondrial...”
LOC118274443 short-chain specific acyl-CoA dehydrogenase, mitochondrial from Spodoptera frugiperda
48% identity, 91% coverage
Q9VDT1 Activator-recruited cofactor subunit 42 from Drosophila melanogaster
49% identity, 91% coverage
I4W091 Acyl-CoA dehydrogenase domain-containing protein from Rhodanobacter fulvus Jip2
48% identity, 97% coverage
- Proteome Analyses of Soil Bacteria Grown in the Presence of Potato Suberin, a Recalcitrant Biopolymer
Sidibé, Microbes and environments 2016 - “...YdiF, acetate-CoA transferase 0.13 I I4VY74 3-oxoacyl-ACP reductase 0.07 I I4VZY3 acetoacetyl-CoA reductase 0.06 E I4W091 acyl-CoA dehydrogenase domain-containing protein 0.04 I I4WAL3 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase 0.08 E I4WAL4 -ketoacyl-[ACP] synthase I 0.12 0.43 E I4WAZ2 acetoacetyl-CoA thiolase 0.66 0.66 E I4WB09 3-hydroxybutyryl-CoA dehydratase 0.13 I I4WB55...”
- “...I4WM94 a , I4WM95 a , I4WPU1 a , I4WM78 a , M4NHA9 a , I4W091 b Q1D3D6, Q1D4E4 b , Q1D5Y1 b , Q1CZW5, A0A0H4WWQ8 enoyl-CoA hydratase I4WR77 b , I4WPL0 Q1D5U2 b 3-hydroxyacyl-CoA dehydrogenase I4WIC4, I4VRU7 a Q1D5U1 b , Q1D233 b acetyl-CoA acetyltransferase...”
Swol_0268 Butyryl-CoA dehydrogenase from Syntrophomonas wolfei subsp. wolfei str. Goettingen
47% identity, 98% coverage
- Stimulating Effect of Trichococcus flocculiformis on a Coculture of Syntrophomonas wolfei and Methanospirillum hungatei
Doloman, Applied and environmental microbiology 2022 - “...a TRAP-type transport system (Swol_0331), electron transfer flavoprotein (Swol_0266) and butyryl coenzyme A (butyryl-CoA) dehydrogenase (Swol_0268) ( Fig. 4A ; see also Table S1). Proteins Swol_0266 and Swol_0268 are in the same operon, while their isoforms, produced from genes located at a different chromosomal location, were...”
- “...critical for the syntrophic growth butyrate conversion step ( 17 , 18 ). Butyryl-CoA dehydrogenase (Swol_0268) catalyzes conversion of butyryl-CoA to crotonyl-CoA and passes the electrons to electron-transfer flavoproteins (Swol_0266). The originally characterized butyryl-CoA dehydrogenase (Swol_2052) by Schmidt et al. ( 17 ) was also detected...”
- Dynamic acylome reveals metabolite driven modifications in Syntrophomonas wolfei
Fu, Frontiers in microbiology 2022 - “...K18 (Acetyl, Butyryl) AEALINIAHPDLRDELVKEAQK 1 Swol_1932 4 K3(Acetyl) YQKLLEEYK 1 Swol_1932 12 K2(Butyryl) SKLVTADEAAK 2 Swol_0268 179 K5(Acetyl); M7(Oxidation) SLGGKGMSAFIISK 2 Swol_0268 194 K6(Acetyl) DNPGLKVGQHFYK 2 Swol_0268 227 K6(Acetyl) EDLLGKEGQGLQIAMSSFDHGR 2 Swol_0268 273 K5(Acetyl) VQFGKPISK 2 Swol_0384 42 K4(Acetyl, Butyryl) DDIKPVLGPILK 2 Swol_0384 343 K6(Acetyl, Butyryl,...”
- Involvement of NADH:acceptor oxidoreductase and butyryl coenzyme A dehydrogenase in reversed electron transport during syntrophic butyrate oxidation by Syntrophomonas wolfei
Müller, Journal of bacteriology 2009 - “...genes for butyryl-CoA dehydrogenases (bcd), one of which (Swol_0268) was colocated in a putative bcd-etfBA operon in synteny to that in C. kluyveri, and...”
B5Y5R5 Short chain acyl-coenzyme A dehydrogenase from Phaeodactylum tricornutum (strain CCAP 1055/1)
50% identity, 86% coverage
4l1fA / D2RL84 Electron transferring flavoprotein of acidaminococcus fermentans: towards a mechanism of flavin-based electron bifurcation (see paper)
46% identity, 98% coverage
- Ligands: flavin-adenine dinucleotide; coenzyme a persulfide; 1,3-propandiol (4l1fA)
D2RL84 butanoyl-CoA dehydrogenase complex (NAD+, ferredoxin) (subunit 1/3) (EC 1.3.1.109); short-chain acyl-CoA dehydrogenase (subunit 1/2) (EC 1.3.8.1) from Acidaminococcus fermentans (see paper)
Acfer_1477 acyl-CoA dehydrogenase domain protein from Acidaminococcus fermentans DSM 20731
46% identity, 98% coverage
- Studies on the mechanism of electron bifurcation catalyzed by electron transferring flavoprotein (Etf) and butyryl-CoA dehydrogenase (Bcd) of Acidaminococcus fermentans
Chowdhury, The Journal of biological chemistry 2014 - “...protein (21). BcdAf is encoded by the Acfer_1477 gene (acyl-CoA dehydrogenase, 383 amino acids). Kinetic Characterization--Although EtfAf and BcdAf are stable...”
- Complete genome sequence of Acidaminococcus fermentans type strain (VR4)
Chang, Standards in genomic sciences 2010 - “...(NAD(P)(+)) (Acfer_1756) is encoded at the beginning of the gene cluster. Three acyl-CoA dehydrogenase genes (Acfer_1477, Acfer_1575 and Acfer_1583) were annotated at various locations, completing the pathway. Nevertheless, genes encoding 2-hydroxyglutarate dehydrogenase and Butyl-CoA:acetate CoA transferase have not yet been identified. Possibly these enzymes have additional...”
- “...glutaconyl-CoA decarboxylase subunit Acfer_1835 glutaconyl-CoA decarboxylase subunit r Acfer_1836 glutaconyl-CoA decarboxylase sodium pump, subunit r Acfer_1477 acyl-CoA dehydrogenase domain protein Acfer_1575 acyl-CoA dehydrogenase domain protein Acfer_1583 acyl-CoA dehydrogenase domain protein Enzymes of -lactamase and the related Acfer_0250 -lactamase domain-containing protein Acfer_0522 Zn-dependent hydrolase of the -lactamase...”
Acfer_1575 acyl-CoA dehydrogenase domain protein from Acidaminococcus fermentans DSM 20731
46% identity, 59% coverage
- Complete genome sequence of Acidaminococcus fermentans type strain (VR4)
Chang, Standards in genomic sciences 2010 - “...(Acfer_1756) is encoded at the beginning of the gene cluster. Three acyl-CoA dehydrogenase genes (Acfer_1477, Acfer_1575 and Acfer_1583) were annotated at various locations, completing the pathway. Nevertheless, genes encoding 2-hydroxyglutarate dehydrogenase and Butyl-CoA:acetate CoA transferase have not yet been identified. Possibly these enzymes have additional functions...”
- “...decarboxylase subunit r Acfer_1836 glutaconyl-CoA decarboxylase sodium pump, subunit r Acfer_1477 acyl-CoA dehydrogenase domain protein Acfer_1575 acyl-CoA dehydrogenase domain protein Acfer_1583 acyl-CoA dehydrogenase domain protein Enzymes of -lactamase and the related Acfer_0250 -lactamase domain-containing protein Acfer_0522 Zn-dependent hydrolase of the -lactamase fold Acfer_0551 RNA-metabolizing metallo--lactamase Acfer_0879...”
RBIBE_18460 acyl-CoA dehydrogenase family protein from Bacillus velezensis
48% identity, 98% coverage
- Complete genome sequence data of chitin-degrading Bacillus velezensis RB.IBE29
Tran, Data in brief 2023 - “...reductase RBIBE_02980 Nitrite reductase small subunit NirD RBIBE_02970 ACC biosynthesis Acyl-CoA dehydrogenase RBIBE_22770 Acyl-CoA dehydrogenase RBIBE_18460 Acyl-CoA dehydrogenase FadE RBIBE_30110 Acyl-CoA dehydrogenase family protein RBIBE_04320 Acyl-CoA synthetase RBIBE_09970 Iron uptake and siderophore production Iron ABC transporter permease RBIBE_01700 Iron ABC transporter permease RBIBE_35840 Iron ABC transporter...”
FNP_1467 acyl-CoA dehydrogenase from Fusobacterium polymorphum ATCC 10953
45% identity, 97% coverage
ACADS_BOVIN / Q3ZBF6 Short-chain specific acyl-CoA dehydrogenase, mitochondrial; SCAD; Butyryl-CoA dehydrogenase; EC 1.3.8.1 from Bos taurus (Bovine) (see paper)
49% identity, 92% coverage
- function: Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (By similarity). Among the different mitochondrial acyl-CoA dehydrogenases, short-chain specific acyl-CoA dehydrogenase acts specifically on acyl- CoAs with saturated 4 to 6 carbons long primary chains (PubMed:6712627).
catalytic activity: a short-chain 2,3-saturated fatty acyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = a short-chain (2E)-enoyl- CoA + reduced [electron-transfer flavoprotein] (RHEA:47196)
catalytic activity: butanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein] (RHEA:24004)
catalytic activity: pentanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-pentenoyl-CoA + reduced [electron-transfer flavoprotein] (RHEA:43456)
catalytic activity: hexanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein] (RHEA:43464)
cofactor: FAD (Binds 1 FAD per subunit.)
subunit: Homotetramer.
Q18AQ1 butanoyl-CoA dehydrogenase complex (NAD+, ferredoxin) (subunit 3/3) (EC 1.3.1.109); short-chain acyl-CoA dehydrogenase (EC 1.3.8.1) from Clostridioides difficile (see paper)
5ol2F / A0A125V4E7 The electron transferring flavoprotein/butyryl-coa dehydrogenase complex from clostridium difficile (see paper)
CD630_10540, CDIF630erm_01194 acyl-CoA dehydrogenase from Clostridioides difficile 630
CD1054 butyryl-CoA dehydrogenase from Clostridium difficile 630
47% identity, 97% coverage
- Ligands: flavin-adenine dinucleotide; coenzyme a persulfide; calcium ion (5ol2F)
- The WalRK Two-Component System Is Essential for Proper Cell Envelope Biogenesis in Clostridioides difficile
Müh, Journal of bacteriology 2022 - “...protein 0.07 2.18 0.62 Membrane cd630_30360 30360 Major facilitator superfamily transporter 1.59 2.13 1.11 Membrane cd630_10540 10540 bcd2 Acyl-CoA dehydrogenase 1.93 2.23 1.03 cd630_10550 10550 etfB Electron transfer flavoprotein beta 1.78 2.11 1.07 cd630_10560 10560 etfA Electron transfer flavoprotein alpha 1.95 2.18 1.10 cd630_10570 10570 crt2...”
- Iron Regulation in Clostridioides difficile
Berges, Frontiers in microbiology 2018 - “...-3.90 -10.48 -4.50 CD630_04010 CDIF630erm_00529 etfA1 Electron transfer flavoprotein subunit alpha -7.50 -3.90 -10.39 -4.98 CD630_10540 CDIF630erm_01194 bcd2 Butyryl-CoA dehydrogenase -5.89 OFF -8.00 OFF CD630_10550 CDIF630erm_01195 etfB Electron transfer flavoprotein subunit beta -7.47 OFF -7.70 OFF CD630_10560 CDIF630erm_01196 etfA Electron transfer flavoprotein subunit alpha -6.75 OFF...”
- “...-10.48 -4.50 CD630_04010 CDIF630erm_00529 etfA1 Electron transfer flavoprotein subunit alpha -7.50 -3.90 -10.39 -4.98 CD630_10540 CDIF630erm_01194 bcd2 Butyryl-CoA dehydrogenase -5.89 OFF -8.00 OFF CD630_10550 CDIF630erm_01195 etfB Electron transfer flavoprotein subunit beta -7.47 OFF -7.70 OFF CD630_10560 CDIF630erm_01196 etfA Electron transfer flavoprotein subunit alpha -6.75 OFF -7.75...”
- “...three different EtfAB systems. The first is encoded downstream the bcd2 gene encoding butyryl-CoA dehydrogenase (CDIF630erm_01194 01199), the second (CDIF630erm_01319 01320) in an operon with lactate racemase (LarA, CDIF630erm_01318) and a lactate dehydrogenase (CDIF630erm_01321) and the third downstream of acdB encoding a short chain acyl-CoA dehydrogenase...”
- Mining Autoimmune-Disorder-Linked Molecular-Mimicry Candidates in Clostridioides difficile and Prospects of Mimic-Based Vaccine Design: An In Silico Approach
Alshamrani, Microorganisms 2023 - “...QWS55813.1 Q18A34 5 WQLVKELKEA SFKHVSPAGAAVG REVSDGIIAPGY KYTQSNSVCYAK GAGQQSRIHCTRLAG 0.73 1.23 20 Acyl-CoA dehydrogenase P16219 QWS55947.1 Q18AQ1 2 LIFEDCRIPK ITEIYEGTSE 0.72 0.99 21 Acetyl-CoA C-acetyltransferase Q9BWD1 QWS55952.1 Q18AR0 2 NASGINDGAA 0.70 0.75 22 Fe-S cluster assembly scaffold protein NifU Q9H1K1 QWS56138.1 Q18BE3 2 GCGSAIASSS 1.01 1.39 23...”
- Diverse Energy-Conserving Pathways in Clostridium difficile: Growth in the Absence of Amino Acid Stickland Acceptors and the Role of the Wood-Ljungdahl Pathway
Gencic, Journal of bacteriology 2020 (secret) - Role of the global regulator Rex in control of NAD+ -regeneration in Clostridioides (Clostridium) difficile
Bouillaut, Molecular microbiology 2019 - “...with the microarrays, we selected a subset of three genes representative of different fermentation pathways (CD1054 ( bcd2, encoding butyryl-CoA dehydrogenase, Fig. 1 (pathway 4)), CD2344 (encoding a membrane protein in the succinate metabolism gene cluster, ( Fig. 1 (pathway 3)) and adhE (encoding acetaldehyde CoA-alcohol...”
- “...qRT-PCR, we measured the relative amounts of prdA (CD3244) , grdE (CD2354), CD2344 and bcd2 (CD1054) mRNAs in the wild-type and rex mutant (LB-CD24) strains. We found that in the absence or in the presence of excess proline, a rex mutation had only a weak effect...”
- Adaptive strategies and pathogenesis of Clostridium difficile from in vivo transcriptomics
Janoir, Infection and immunity 2013 - “...3-hydroxybutyryl-CoA-dehydrogenase; CD1057, 3-hydroxybutyryl-CoA dehydratase; CD1054, butyryl-CoA dehydrogenase; CD1055-CD1056, electron transfer flavoproteins;...”
- “...involved in the conversion of acetyl-CoA into butyryl-CoA (CD1054 to CD1059) was constitutively expressed, since this operon was downregulated at 38 h in vitro...”
- Effect of an oxygen-tolerant bifurcating butyryl coenzyme A dehydrogenase/electron-transferring flavoprotein complex from Clostridium difficile on butyrate production in Escherichia coli
Aboulnaga, Journal of bacteriology 2013 - “...EC 1.3.99.2), comprising the dehydrogenase subunit (CD1054, bcd2), electron transfer flavoprotein subunit beta (CD1055, etfB2), electron transfer flavoprotein...”
- Global transcriptional control by glucose and carbon regulator CcpA in Clostridium difficile
Antunes, Nucleic acids research 2012 - “...succinate-semialdehyde dehydrogenase; 4hbd (CD2338), 4-hydroxybutyrate dehydrogenase; cat2 (CD2339), 4-hydroxybutyrate CoA transferase; abfD (CD2341), vinylacetyl-coa--isomerase; bcd2 (CD1054), butyryl-CoA dehydrogenase; etfBA (CD1055CD1056), electron transfer flavoproteins; ptb (CD0715, CD0112), phosphate butyryltransferase; buk (CD0113), butyrate kinase. After sugar uptake, the carbohydrates are metabolized through the central carbon metabolism to produce...”
- Comparative transcriptional analysis of clinically relevant heat stress response in Clostridium difficile strain 630
Ternan, PloS one 2012 - “...which converts acetyl-CoA and formate to CoA and pyruvate, during metabolism of propanoate and butanoate. CD1054 and CD1056, encoding butyryl-CoA dehydrogenase ( bcd2 ) and an electron transfer flavoprotein alpha-subunit ( etfA2 ), two enzymes of the butanoate metabolic pathway were also upregulated. The phosphotransferase (PTS)...”
- Proteomic and genomic characterization of highly infectious Clostridium difficile 630 spores
Lawley, Journal of bacteriology 2009 - “...A dehydrogenase enzymes and electron transfer proteins (CD1054 to CD1059) (18) (Fig. 5b). KEGG pathway analysis (http://www .genome.ad.jp/kegg) (see Table S1...”
FN0783 Acyl-CoA dehydrogenase from Fusobacterium nucleatum subsp. nucleatum ATCC 25586
45% identity, 97% coverage
CTK_C26200 acyl-CoA dehydrogenase from Clostridium tyrobutyricum
45% identity, 97% coverage
bcd / A0A1G6BBN2 butanoyl-CoA dehydrogenase monomer from Eubacterium oxidoreducens (see paper)
46% identity, 98% coverage
P79273 Short-chain specific acyl-CoA dehydrogenase, mitochondrial from Sus scrofa
49% identity, 92% coverage
- Evaluating nursery pig responses to in-feed sub-therapeutic antibiotics
Helm, PloS one 2019 - “...Ras-related protein Rab-14 Q52NJ6 -0.966 0.045 Phostensin Q767M0 1.124 0.043 Short-chain specific acyl-CoA dehydrogenase, mitochondrial P79273 0.564 0.041 Longissimus muscle Elongation factor 1-gamma (Fragment) Q29387 -0.793 0.001 Malate dehydrogenase, cytoplasmic P11708 -0.458 0.049 Liver 40S ribosomal protein S12 P46405 0.251 0.025 40S ribosomal protein S20 A1XQU9...”
- Reproducible ion-current-based approach for 24-plex comparison of the tissue proteomes of hibernating versus normal myocardium in swine models
Qu, Journal of proteome research 2014 - “...carnitine O -palmitoyltransferase1, muscle isoform 0.71 PCCB P79384 propionyl-CoAcarboxylasebetachain 0.76 ACADL P79274 long-chainspecificacyl-CoAdehydrogenase 0.75 ACADS P79273 short-chainspecificacyl-CoAdehydrogenase 0.76 ACADV P49748 verylong-chainspecificacyl-CoA dehydrogenase 0.79 Amino Acid Catabolism, Mitochondrial IVD P26440 isovaleryl-CoAdehydrogenase 0.55 MMSA Q02252 methylmalonate-semialdehyde dehydrogenase [acylating] 0.61 Out of 113 quantifiable proteins localizing to mitochondrion, 17...”
KR505_10030 acyl-CoA dehydrogenase from Eubacterium callanderi
46% identity, 97% coverage
- Gut Microbiota Eubacterium callanderi Exerts Anti-Colorectal Cancer Activity
Ryu, Microbiology spectrum 2022 - “...butyric acid biosynthesis. But , butyryl-CoA:acetate CoA transferase (locus_tag, KR505_02670); Bcd , butyryl-CoA dehydrogenase (KR505_02675, KR505_10030); ETF , electron transfer flavoprotein subunit alpha (KR505_10020); ETF , electron transfer flavoprotein subunit beta (KR505_10025); Hbd , hydroxybutyryl dehydrogenase (KR505_10035); Cro , crotonase/enoyl-CoA hydratase (KR505_10040); Thl , acetyl-CoA C-acetyltransferase...”
NP_978856 acyl-CoA dehydrogenase from Bacillus cereus ATCC 10987
48% identity, 98% coverage
- Acyl-CoA dehydrogenases: Dynamic history of protein family evolution
Swigonová, Journal of molecular evolution 2009 - “...proteins with homology to SCAD ( Fig. 6b ) in Acidobacteria bacterium (ABF41370), Bacillus cereus (NP_978856), and Geobacillus kaustophilus (YP_147450). With the exception of the active site catalytic residue position and the residue equivalent to human IVD Y371, which is distant in the active site, other...”
Cbei_2883 acyl-CoA dehydrogenase domain-containing protein from Clostridium beijerincki NCIMB 8052
46% identity, 97% coverage
FN1424 ACYL-COA dehydrogenase, short-chain specific from Fusobacterium nucleatum subsp. nucleatum ATCC 25586
46% identity, 59% coverage
CBO3199 butyryl-CoA dehydrogenase from Clostridium botulinum A str. ATCC 3502
43% identity, 97% coverage
- Heat shock and prolonged heat stress attenuate neurotoxin and sporulation gene expression in group I Clostridium botulinum strain ATCC 3502
Selby, PloS one 2017 - “...sigE ), motility ( sigD , cheA , and flgE ), and carbon metabolism ( cbo3199 , cbo3202 ), and included genes showing significantly activated or suppressed, or unaffected transcription levels in the microarray analysis. A linear regression analysis revealed a strong correlation between the log...”
- “...compounds in heat stressed C . botulinum culture. Two of these genes ( cbo3202 and cbo3199 ) were linked also to low-temperature stress response of ATCC 3502 at 17C [ 65 ]. Interestingly, butyrate in the growth medium has been shown to induce toxin synthesis by...”
- The cold-induced two-component system CBO0366/CBO0365 regulates metabolic pathways with novel roles in group I Clostridium botulinum ATCC 3502 cold tolerance
Dahlsten, Applied and environmental microbiology 2014 - “...509 in antisense orientation, erm Insertional disruption of cbo3199 at base 467 in antisense orientation, erm Insertional disruption of cbo3202 at base 167 in...”
- “...pMTL007C-E2 with L1.LtrB retargeted to base 467 of cbo3199 in antisense orientation pMTL007C-E2 with L1.LtrB retargeted to base 167 of cbo3202 in antisense...”
- Transcriptomic analysis of (group I) Clostridium botulinum ATCC 3502 cold shock response
Dahlsten, PloS one 2014 - “..., cbo0753 , cbo1407 , cbo2226 , cbo2227 , cbo2525 , cbo2847 , cbo2961 , cbo3199 and cbo3202 one hour after the cold shock, normalized to 16S rrn transcript levels and calibrated to pre-cold-shock transcript levels, were calculated using the Cq values obtained from qPCR runs....”
- “...obtained in a previous study [13] for genes cbo0751, cbo0753, cbo1407, cbo2226, cbo2227, cbo2525, cbo2847, cbo3199 , and cbo3202 ; all other data were produced in the current study. In a linear regression analysis between the microarray and RT-qPCR log 2 fold changes ( Fig. 2...”
BA2547 acyl-CoA dehydrogenase from Bacillus anthracis str. Ames
48% identity, 98% coverage
Elgi_67150 acyl-CoA dehydrogenase from Paenibacillus elgii
46% identity, 99% coverage
- Data on annotation and analysis of genome sequence of Paenibacillus elgii YSY-1.2, a promising chitinase-producing, plant-growth-promoting, and biocontrol agent
Tran, Data in brief 2024 - “...Elgi_17100 Nitrate transporter NarK Elgi_46520 ACC biosynthesis Acyl-CoA dehydrogenase FadE Elgi_23140 Acyl-CoA dehydrogenase Elgi_47060, Elgi_54500, Elgi_67150 Acyl-CoA dehydrogenase family protein Elgi_51250 Acyl-CoA dehydrogenase AcdA Elgi_54520 Iron uptake Iron ABC transporter permease Elgi_01060, Elgi_13560, Elgi_13570, Elgi_14480, Elgi_14540, Elgi_15350, Elgi_16730, Elgi_25990, Elgi_26000, Elgi_27700, Elgi_29320, Elgi_29330, Elgi_33950, Elgi_46590, Elgi_47580,...”
ANACAC_00253 hypothetical protein from Anaerostipes caccae DSM 14662
45% identity, 98% coverage
WP_069875591 acyl-CoA dehydrogenase from Fusibacter sp. 3D3
44% identity, 97% coverage
CBY_3042 acyl-coa dehydrogenase, short-chain specific from Clostridium butyricum 5521
CLP_3853 acyl-CoA dehydrogenase from Clostridium butyricum E4 str. BoNT E BL5262
45% identity, 97% coverage
- Reduced catabolic protein expression in Clostridium butyricum DSM 10702 correlate with reduced 1,3-propanediol synthesis at high glycerol loading
Gungormusler-Yilmaz, AMB Express 2014 - “...0.26 0.32 0.38 0.33 CBY_3041 3-hydroxybutyryl-CoA dehydratase 0.50 0.29 1.17 1.11 NQ NQ NQ NQ CBY_3042 acyl-coa dehydrogenase (short-chain specific) 0.20 0.25 0.90 0.60 0.06 0.06 0.96 0.94 CBY_3045 3-hydroxybutyryl-coa dehydrogenase 0.24 0.20 1.16 1.28 0.31 0.06 0.04 0.30 CBY_3235 Glycerol dehydrogenase c 0.02 0.52 1.47...”
- Type E Botulinum Neurotoxin-Producing Clostridium butyricum Strains Are Aerotolerant during Vegetative Growth
Camerini, mSystems 2019 - “...1.55 Carbohydrate metabolism 10 488644944 CLP_0793 Pyruvate formate-lyase-activating enzyme 1.85 Fe-S Carbohydrate metabolism 11 489505871 CLP_3853 Butyryl-CoA dehydrogenase 0.95 Carbohydrate metabolism: butyrate synthesis pathway 12 489506129 CLP_3852 Electron transfer flavoprotein, beta subunit 1.13 Electron transfer Carbohydrate metabolism: butyrate synthesis pathway 13 906848776 CLP_3850 3-Hydroxybutyryl-CoA dehydrogenase 1.24...”
- “...box with a red arrow indicating their downmodulation. (CLP_0793, pyruvate formate-lyase-activating enzyme; CLP_3850, 3-hydroxybutyryl-CoA dehydrogenase; CLP_3853, butyryl-CoA dehydrogenase; CLP_3852, electron transfer flavoprotein, beta subunit). Furthermore, the proteomics analysis showed that three enzymes of the butyrate metabolic pathway were downregulated under AE conditions, suggesting that oxygen induced...”
CBY_3258 acyl-coa dehydrogenase, short-chain specific from Clostridium butyricum 5521
45% identity, 97% coverage
- Reduced catabolic protein expression in Clostridium butyricum DSM 10702 correlate with reduced 1,3-propanediol synthesis at high glycerol loading
Gungormusler-Yilmaz, AMB Express 2014 - “...0.06 0.04 0.30 CBY_3235 Glycerol dehydrogenase c 0.02 0.52 1.47 2.23 0.34 0.36 2.66 2.70 CBY_3258 acyl-coa dehydrogenase (short-chain specific) 0.13 0.41 0.39 0.20 0.16 0.64 1.51 1.05 CBY_3642 pyruvate:ferredoxin oxidoreductase 0.05 0.29 0.02 0.35 0.01 0.49 1.04 0.56 CBY_3690 dihydroxyacetone kinase.(L subunit) 0.57 0.75 1.75...”
- “...FeFe hydrogenase (CBY_2300), acetyl CoA acetyltransferase (CBY_1290), 3-hydroxybutyryl-CoA dehydrogenase (CBY_3045), 3-hydroxybutyryl-coa dehydratase (CBY_3041), acyl-CoA dehydrogenase (CBY_3258 and 3042), phosphate butyryltransferase (CBY_2919), butyrate kinase (CBY_2920), butanol dehydrogenase (CBY_3747 and 3751), phosphate acetyltransferase (CBY_0205), acetate kinase (CBY_0206), lactate dehydrogenase (CBY_0742, 2341 and 2757), and ethanol dehydrogenase (CBY_3753) (Figure...”
Dtox_1697 acyl-CoA dehydrogenase domain protein from Desulfotomaculum acetoxidans DSM 771
46% identity, 97% coverage
- Complete genome sequence of Desulfotomaculum acetoxidans type strain (5575)
Spring, Standards in genomic sciences 2009 - “...related homoacetogenic bacterium Moorella thermoacetica ( cooC/acsE ) [ 31 ]. A cluster of genes (Dtox_1697 to 1703) that is probably required for growth with butyrate as substrate could be also identified. It has been reported that acetate accumulates upon growth on butyrate and that acetate...”
Dred_1782 Butyryl-CoA dehydrogenase from Desulfotomaculum reducens MI-1
47% identity, 97% coverage
- Comparative Proteomic Analysis of Desulfotomaculum reducens MI-1: Insights into the Metabolic Versatility of a Gram-Positive Sulfate- and Metal-Reducing Bacterium
Otwell, Frontiers in microbiology 2016 - “...0.39 (0.01) 3.29 (<0.01) C Dred_1781 Enoyl-CoA hydratase/isomerase 2.12 (<0.01) 2.12 (<0.01) 4.07 (<0.01) C Dred_1782 butyryl-CoA dehydrogenase 0.62 (0.02) 0.17 1.84 (<0.01) C Dred_1783 Hypothetical protein (HdrD) 0.98 (<0.01) 0.87 (<0.01) 1.87 (<0.01) CM Dred_1784 Acetyl-CoA acetyltransferase 0.71 (<0.01) 0.41 3.49 (<0.01) C Protein identification...”
- “...17.2 on pyruvate, 20.8 on sulfate, and 8.0 on Fe(III)-oxide. Five proteins in this cluster (Dred_1782, Dred_1784, and Dred_1778-80) fall into the top 20 proteins across the Fe(III)-citrate proteome with respect to highest unique peptide counts. This result is surprising because these genes are predicted to...”
Dred_0402 acyl-CoA dehydrogenase domain protein from Desulfotomaculum reducens MI-1
44% identity, 98% coverage
PG1076 acyl-CoA dehydrogenase, short-chain specific from Porphyromonas gingivalis W83
44% identity, 98% coverage
- Protective role of the PG1036-PG1037-PG1038 operon in oxidative stress in Porphyromonas gingivalis W83
Henry, PloS one 2013 - “...PG1080 * 3-hydroxybutyryl-CoA dehydrogenase 30 kDa Fatty acid and phospholipid metabolism Oxidoreductase activity; Coenzyme binding PG1076 Butyryl-CoA dehydrogenase 42 kDa Fatty acid and phospholipid metabolism Acyl-CoA dehydrogenase activity; Oxidoreductase activity, acting on the CH-CH group of donors; FAD binding PG1069 Zinc-containing alcohol dehydrogenase 37 kDa Energy...”
- Response of Porphyromonas gingivalis to heme limitation in continuous culture
Dashper, Journal of bacteriology 2009 - “...7 PG0690h PG0691h PG0692 8 PG1067 9 PG1068 10 11 PG1075h PG1076 12 PG1078 13 14 PG1079h PG1081 15 PG1082 16 PG1232 17 PG1271 18 PG1417 19 PG1612 20 PG1614 21...”
- “...involved in glutamate catabolism, acyl-CoA dehydrogenase (PG1076) and the subunit of an electron transfer flavoprotein (PG1078), significantly increased...”
- Comparative transcriptomic analysis of Porphyromonas gingivalis biofilm and planktonic cells
Lo, BMC microbiology 2009 - “...branching point in this pathway between butyrate and propionate end-products. Three genes PG0690, PG1075 and PG1076 encoding 4-hydroxybutyrate CoA-transferase, the coenzyme A transferase beta subunit and acyl-CoA dehydrogenase (short-chain specific) respectively, that are in the pathway branch that produces butyrate, were down-regulated, as were a cluster...”
- Role of oxyR in the oral anaerobe Porphyromonas gingivalis
Diaz, Journal of bacteriology 2006 - “...PG1540 PG1124 PG0257 PG0888 PG1089 PG1960 PG0385 PG0707 PG1076 PG0037 PG0595 PG2117 PG1134 PG1108 PG0594 PG0193 PG1542 PG0434 Alkyl hydroperoxide reductase, C...”
PGN_1172 acyl-CoA dehydrogenase short-chain specific from Porphyromonas gingivalis ATCC 33277
44% identity, 98% coverage
- Insights into Dynamic Polymicrobial Synergy Revealed by Time-Coursed RNA-Seq
Hendrickson, Frontiers in microbiology 2017 - “...TonB-dependent receptor 0.56 0.52 0.50 0.80 1.00 PGN_1111 formate-tetrahydrofolate ligase 0.56 0.01 0.79 0.65 0.70 PGN_1172 acyl-CoA dehydrogenase short-chain specific 0.95 0.89 0.64 0.63 0.64 PGN_1186 rprY , DNA-binding response regulator 0.85 0.37 0.10 0.12 0.71 PGN_1206 putative methylenetetrahydrofolate dehydrogenase 0.07 0.08 0.25 0.57 0.51 PGN_1221...”
Cbei_0322 acyl-CoA dehydrogenase domain-containing protein from Clostridium beijerincki NCIMB 8052
44% identity, 97% coverage
- Model-driven approach for the production of butyrate from CO2/H2 by a novel co-culture of C. autoethanogenum and C. beijerinckii
Benito-Vaquerizo, Frontiers in microbiology 2022 - “...dehydrogenase/electron-transferring flavoprotein complex (Bcd-EtfAB) producing reduced ferredoxin. Two complete clusters were identified in the genome: Cbei_0322 (Bcd), Cbei_0323 (EtfB), and Cbei_0324 (EtfA) or Cbei_2035 (Bcd), Cbei_2036 (EtfB) and Cbei_2037 (EtfA). An acyl-CoA dehydrogenase (Acd) showed 79.4% similarity with the Bcd subunit of C. acetobutylicum ATCC 824....”
- Sigma Factor Regulated Cellular Response in a Non-solvent Producing Clostridium beijerinckii Degenerated Strain: A Comparative Transcriptome Analysis
Zhang, Frontiers in microbiology 2017 - “...Cbei_2037) catalyzing acetoacetyl-CoA into 3-hydroxybutyryl-CoA; Enoyl-CoA hydratase (Cbei_2231, Cbei_2230) catalyzing 3-hydroxybutyryl-CoA into crotonyl-CoA; butyryl-CoA dehydrogenase (Cbei_0322, Cbei_2035, Cbei_2883) catalyzing crotonyl-CoA into butyryl-CoA ( Figures 3D and 4C ; Supplementary Table S5f ). Cellular Aging and Scavenging Ability of Reactive Oxygen Species To investigate the differences in...”
- Transcriptional analysis of degenerate strain Clostridium beijerinckii DG-8052 reveals a pleiotropic response to CaCO3-associated recovery of solvent production
Jiao, Scientific reports 2016 - “...sensitivity to CaCO 3. The transcription of 3-hydroxybutyryl-CoA dehydrogenase (Cbei_0325), 3-hydroxybutyryl-CoA (Cbei_0324) and butyryl-CoA dehydrogenase (Cbei_0322) was not changed significantly by the addition of CaCO 3 to the DG-8052 culture. It is reported that phosphoenolpyruvate (PEP), pyruvate, and acetyl-CoA form three main key nodes in the...”
Cbei_2035 acyl-CoA dehydrogenase domain-containing protein from Clostridium beijerincki NCIMB 8052
45% identity, 97% coverage
DSY1568 hypothetical protein from Desulfitobacterium hafniense Y51
45% identity, 97% coverage
B7P7P2 Medium-chain acyl-CoA dehydrogenase, putative (Fragment) from Ixodes scapularis
46% identity, 91% coverage
ACDS_CLOAB / P52042 Acyl-CoA dehydrogenase, short-chain specific; Butyryl-CoA dehydrogenase; SCAD; EC 1.3.8.1 from Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / IAM 19013 / LMG 5710 / NBRC 13948 / NRRL B-527 / VKM B-1787 / 2291 / W) (see paper)
bcd butyryl-CoA dehydrogenase; EC 1.3.99.2 from Clostridium acetobutylicum (see paper)
CAC2711 Butyryl-CoA dehydrogenase from Clostridium acetobutylicum ATCC 824
CA_C2711 acyl-CoA dehydrogenase from Clostridium acetobutylicum
44% identity, 98% coverage
- catalytic activity: butanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein] (RHEA:24004)
catalytic activity: a short-chain 2,3-saturated fatty acyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = a short-chain (2E)-enoyl- CoA + reduced [electron-transfer flavoprotein] (RHEA:47196)
cofactor: FAD - Transcriptional analysis of micronutrient zinc-associated response for enhanced carbohydrate utilization and earlier solventogenesis in Clostridium acetobutylicum
Wu, Scientific reports 2015 - “...pyruvate to butyryl-CoA formation genes, thlA (CAC2873), crt (CAC2712), etfA (CAC2709), etfB (CAC2710), and bcd (CAC2711) were differentially upregulated by no more than 1.75-fold. Surprisingly, thlB (CAC0078) encoding acetyl-CoA acetyltransferase was 0.65-fold downregulated compared to 1.46-fold upregulation of the primary thiolase gene thlA in the presence...”
- Redox-responsive repressor Rex modulates alcohol production and oxidative stress tolerance in Clostridium acetobutylicum
Zhang, Journal of bacteriology 2014 - “...asrA asrB asrC CAP0035 CAC0267 CAC2873 CAC2712 CAC2711 CAC2710 CAC2709 CAC2708 CAC3076 CAC3075 CAC1025 CAC1024 CAC1023 CAC1512 CAC1513 CAC1514 CAC1515 164.75...”
- Meta-analysis and functional validation of nutritional requirements of solventogenic Clostridia growing under butanol stress conditions and coutilization of D-glucose and D-xylose
Heluane, Applied and environmental microbiology 2011 - “...P CAC2235 CAC2388 CAC2389 CAC2390 CAC2634 CAC2708 CAC2711 CAC2712 CAC3164 CAC3170 CAC3348 CAC3462 CAC3596 CAC3680 CAC3681 0.40506 1.51803 1.07553 1.7949 2.70695...”
- A proteomic and transcriptional view of acidogenic and solventogenic steady-state cells of Clostridium acetobutylicum in a chemostat culture
Janssen, Applied microbiology and biotechnology 2010 - “...0.6 T CAC2709 etfA Electron transfer flavoprotein alpha-subunit 2.3 2.0 5.4 2.4 3.0 1.6 C CAC2711 bcd Butyryl-CoA dehydrogenase 2.0 1.8 6.1 2.4 3.1 2.0 I CAC2712 crt Enoyl-CoA hydratase 2.1 1.8 7.2 2.9 3.5 2.5 I CAC2810 Glucoamylase family protein 2.7 2.2 10.1 4.9 5.0...”
- “...A ( thlA , CAC2873), crotonase ( crt , CAC2712), butyryl-CoA dehydrogenase ( bcd , CAC2711), and the subunit of the electron transfer flavoprotein ( etfA , CAC2709). Otherwise, 3-hydroxybutyryl-CoA dehydrogenase ( hbd , CAC2708) and the second subunit of the electron transfer flavoprotein ( etfB...”
- The role of PerR in O2-affected gene expression of Clostridium acetobutylicum
Hillmann, Journal of bacteriology 2009 - “...CAC2452 CAC2458 CAC2459 CAC2499 CAC2708 CAC2709 CAC2710 CAC2711 CAC2712 CAC2873 CAC3075 CAC3076 CAC3657 CAC3658 CAC3659 Arginine biosynthesis CAC0316 CAC0376...”
- Transcriptional program of early sporulation and stationary-phase events in Clostridium acetobutylicum
Alsaker, Journal of bacteriology 2005 - “...crt (CAC2712), etfA (CAC2709), etfB (CAC2710), and bcd (CAC2711) generally increased in stationary phase but not more than 1.9-fold. Two previous analyses of...”
- Comparative analysis of gene expression among low G+C gram-positive genomes
Karlin, Proceedings of the National Academy of Sciences of the United States of America 2004 - “...Table 2. (continued) E(g)* Gene Butyryl-CoA dehydrogenase (CAC2711) Pyruvate ferredoxin oxidoreductase (CAC2229, CPE2061) BACSU BACHA (0.56) (0.48) (0.41) -...”
- Transcriptional analysis of spo0A overexpression in Clostridium acetobutylicum and its effect on the cell's response to butanol stress
Alsaker, Journal of bacteriology 2004 - “...hbd (CAC2708, encoding -hydroxybutyrylCoA dehydrogenase), bcd (CAC2711, encoding butyryl-CoA dehydrogenase), thl (CAC2873, encoding thiolase), and buk (CAC3075,...”
- Looking for the mechanism of arsenate respiration of Fusibacter sp. strain 3D3, independent of ArrAB
Acosta-Grinok, Frontiers in microbiology 2022 - “...3 10 141 Bcd Electron bifurcating butyryl-CoA dehydrogenase (NAD + , ferredoxin) WP_069875591 Clostridium acetobutylicum P52042 0 EtfA-1 Electron transfer flavoprotein, subunit WP_069871749 Clostridium saccharobutylicum P53578 5 10 128 EtfB-1 Electron transfer flavoprotein, subunit WP_069871747 Clostridium amylolyticum A0A1M6NXL2 2 10 133 LdhD Lactate/Glycolate dehydrogenase, subunit LdhD/GlcD...”
- New perspectives on butyrate assimilation in Rhodospirillum rubrum S1H under photoheterotrophic conditions
De, BMC microbiology 2020 - “...rubrum genome, of the butyryl-CoA dehydrogenase reviewed in Clostridium acetobutylicum [ 19 ] (accession number P52042) or Megasphaera elsdenii [ 20 ] (accession number Q06319). As already described in Desulfosarcina cetonica [ 4 ] in the context of butyrate catabolism, crotonyl-CoA is proposed to be further...”
- Quantitative proteomic analysis of the influence of lignin on biofuel production by Clostridium acetobutylicum ATCC 824
Raut, Biotechnology for biofuels 2016 - “...] also proposed in Clostridium kluyveri [ 68 ]. Interestingly, we identified butyryl-CoA dehydrogenase (Bcd) (CA_C2711), electron transfer flavoprotein (subunit etfA (CA_C2709) and etfB (CA_C2710) and probable NADH/NADPH oxidoreductase (CA_C1958) in both conditions, suggesting the presence of extra energy conserving modules in this bacterium. Conclusions In...”
- A Quantitative System-Scale Characterization of the Metabolism of Clostridium acetobutylicum
Yoo, mBio 2015 - “...and electron fluxes. The previously uncharacterized butyryl coenzyme A (butyryl-CoA) dehydrogenase (BCD) encoded by bcd-etfB-etfA (CA_C2711, CA_C2710, and CA_C2709, respectively) ( 42 ) was biochemically characterized via homologous expression of the encoding operon in C.acetobutylicum and the purification of the enzyme complex ( Table2 ; see...”
- “...potentially catalyze this reaction: the BCD complex encoded by bcd , etfB , and etfA (CA_C2711, CA_C2710, and CA_C2709, respectively) which consumes 2moles of NADH and produces 1mole of reduced ferredoxin (see Fig.S1 in the supplemental material) and TER ( trans -2-enoyl-CoA reductase) encoded by CA_C0642,...”
- Fermentation of oxidized hexose derivatives by Clostridium acetobutylicum
Servinsky, Microbial cell factories 2014 - “...kinase, CA_C1743; 17) hydroxybutyryl-CoA dehydrogenase, CA_C2009, CA_C2708; 18) crotonase, CA_C2012, CA_C2016, CA_C2712; 19) butyryl-CoA dehydrogenase, CA_C2711; 20) phosphotransbutyrylase, CA_C3076; 21) butyrate kinase, CA_C1660, CA_C3075; 22) galacturonate symporter, CA_C0694; 23) galacturonate isomerase, CA_C0692 24) altronate oxidoreductase, CA_C0695; 25) altronate dehydratase, CA_C0696; 26) 2-keto-3-deoxygluconokinase, CA_C0395; 27) 2-keto-3-deoxygluconate 6-phosphate...”
- Converting carbon dioxide to butyrate with an engineered strain of Clostridium ljungdahlii
Ueki, mBio 2014 - “...The amplified genes were thl (NCBI GenBank; CA_C2873), crt (NCBI GenBank; CA_C2712), bcd (NCBI GenBank; CA_C2711), etfB (NCBI GenBank, CA_C2710), etfA (NCBI GenBank; CA_C2709), hbd (NCBI GenBank; CA_C2708), buk (NCBI GenBank; CA_C3075), and ptb (NCBI GenBank; CA_C3076). Primers used for the PCR are listed in TableS1...”
- Rapid construction of metabolic models for a family of Cyanobacteria using a multiple source annotation workflow
Mueller, BMC systems biology 2013 - “...the adhA gene in Synechocystis 6803. EC-gene relationships: 2.3.1.9: CA_C2873, 1.1.1.36: CA_C2708, 4.2.1.17: CA_C2712, 1.3.99.2: CA_C2711, 1.2.1.10: CA_P0035, 1.1.1.-: slr1192. The proposed workflow also served to complete unfinished pathways from i Cyt773. All five models are capable of converting galactose-1-phosphate to fructose-6-phosphate as in i Cyt773....”
Ccar_22795 acyl-CoA dehydrogenase from Clostridium carboxidivorans P7
42% identity, 97% coverage
- Combination of Trace Metal to Improve Solventogenesis of Clostridium carboxidivorans P7 in Syngas Fermentation
Han, Frontiers in microbiology 2020 - “...fdhII Formate dehydrogenase Ccar_03945 fdhIII Formate dehydrogenase Ccar_13505 fdhIV Formate dehydrogenase Ccar_16050 fdhV Formate dehydrogenase Ccar_22795 bcd Butyryl-CoA dehydrogenase Butyral-CoA synthesis from acetyl-CoA Ccar_22780 crt Crotonase Ccar_22785 hbd 3-Hydroxybutyryl-CoA dehydrogenase Ccar_22790 thl Acetyl-CoA acetyltransferase Ccar_22800 etfB Electron transfer flavoprotein Ccar_22805 etfA Electron transfer flavoprotein subunit alpha...”
Q1D5Y1 Acyl-CoA dehydrogenase from Myxococcus xanthus (strain DK1622)
44% identity, 98% coverage
- Proteome Analyses of Soil Bacteria Grown in the Presence of Potato Suberin, a Recalcitrant Biopolymer
Sidibé, Microbes and environments 2016 - “...0.03 I Q1D5Y4 3-hydroxybutyryl-CoA dehydratase 0.05 I Q1D8V2 acetyl-coenzyme A carboxylase carboxyl transferase 0.05 I Q1D5Y1 acyl-CoA dehydrogenase 0.04 I Q1D5W1 patatin-like phospholipase 0.01 E Q1D5V2 3-oxoacid CoA-transferase 0.07 I Q1D855 long-chain-fatty-acid-CoA ligase 0.02 I Q1D566 acyltransferase 0.02 I Q1CZW5 acyl-CoA dehydrogenase 0.02 0.02 I Q1D003...”
- “...I4WPU1 a , I4WM78 a , M4NHA9 a , I4W091 b Q1D3D6, Q1D4E4 b , Q1D5Y1 b , Q1CZW5, A0A0H4WWQ8 enoyl-CoA hydratase I4WR77 b , I4WPL0 Q1D5U2 b 3-hydroxyacyl-CoA dehydrogenase I4WIC4, I4VRU7 a Q1D5U1 b , Q1D233 b acetyl-CoA acetyltransferase I4WBZ6, I4WIC3 Q1D5VO, Q1D234 b ,...”
acrC / G3KIM8 propionyl-CoA dehydrogenase from Anaerotignum propionicum (see paper)
ACRC_ANAPI / G3KIM8 Acryloyl-CoA reductase (NADH); Propionyl-CoA dehydrogenase; EC 1.3.1.95 from Anaerotignum propionicum (Clostridium propionicum) (see paper)
45% identity, 95% coverage
- function: Probable catalytic subunit of the acryloyl-CoA reductase complex involved in the pathway of L-alanine fermentation. Catalyzes the irreversible NADH-dependent formation of propionyl-CoA from acryloyl-CoA. It can also use 3-buten-2-one as substrate.
catalytic activity: propanoyl-CoA + NAD(+) = acryloyl-CoA + NADH + H(+) (RHEA:34471)
cofactor: FAD
subunit: Heterohexadecamer; tetramer of tetramers. Each tetramer is composed of 2 alpha (AcrC), a beta (AcrA) and a gamma (AcrB) subunit.
Sfum_3931 acyl-CoA dehydrogenase domain protein from Syntrophobacter fumaroxidans MPOB
45% identity, 94% coverage
- Complete genome sequence of Syntrophobacter fumaroxidans strain (MPOB(T))
Plugge, Standards in genomic sciences 2012 - “...this gene cluster, as are genes for a putative hydroxylase (Sfum_3932) and an acyl-CoA dehydrogenase (Sfum_3931). Additionally, a gene annotated as an FAD-dependent oxidoreductase (Sfum_3927) and one encoding a 4Fe-4S ferredoxin-binding domain (Sfum_3926) are part of this gene cluster. Genes predicted to encode a sigma 54-dependent...”
Elgi_54500 acyl-CoA dehydrogenase family protein from Paenibacillus elgii
44% identity, 98% coverage
- Data on annotation and analysis of genome sequence of Paenibacillus elgii YSY-1.2, a promising chitinase-producing, plant-growth-promoting, and biocontrol agent
Tran, Data in brief 2024 - “...transporter Elgi_17100 Nitrate transporter NarK Elgi_46520 ACC biosynthesis Acyl-CoA dehydrogenase FadE Elgi_23140 Acyl-CoA dehydrogenase Elgi_47060, Elgi_54500, Elgi_67150 Acyl-CoA dehydrogenase family protein Elgi_51250 Acyl-CoA dehydrogenase AcdA Elgi_54520 Iron uptake Iron ABC transporter permease Elgi_01060, Elgi_13560, Elgi_13570, Elgi_14480, Elgi_14540, Elgi_15350, Elgi_16730, Elgi_25990, Elgi_26000, Elgi_27700, Elgi_29320, Elgi_29330, Elgi_33950, Elgi_46590,...”
CTK_C26360 acyl-CoA dehydrogenase from Clostridium tyrobutyricum
42% identity, 97% coverage
CTC_RS10685 acyl-CoA dehydrogenase from Clostridium tetani E88
40% identity, 98% coverage
- Regulation of Clostridium tetani Neurotoxin Expression by Culture Conditions
Pennings, Toxins 2022 - “...tetX ( Figure 4 , brown cluster). Apart from tetX , these included acyl-CoA dehydrogenase (CTC_RS10685), amino acid permease (CTC_RS04695), ethanolamine utilization protein (CTC_RS11165), and five hypothetical proteins (CTC_RS05450, CTC_RS08030, CTC_RS08110, CTC_RS10695, CTC_RS13650). When adjacent clusters were included, we found a set of 20 DEGs for...”
HMPREF0389_00744 acyl-CoA dehydrogenase from Filifactor alocis ATCC 35896
46% identity, 98% coverage
- FACIN, a Double-Edged Sword of the Emerging Periodontal Pathogen Filifactor alocis: A Metabolic Enzyme Moonlighting as a Complement Inhibitor
Jusko, Journal of immunology (Baltimore, Md. : 1950) 2016 - “...HMPREF0389_01570 Acetylornithine aminotransferase 849/1.72 36(32) 44653 4 HMPREF0389_01649 NAD-specific glutamate dehydrogenase 145/0.22 4(4) 47231 5 HMPREF0389_00744 Butyryl-CoA dehydrogenase 665/1.15 18(17) 41459 5 HMPREF0389_00567 Glyceraldehyde-3-phosphate dehydrogenase 102/0.18 2(2) 37599 a Accession numbers and protein descriptions are from the NCBI- F. alocis genome project ( http://www.ncbi.nlm.nih.gov/genomeprj/30485 ) b...”
- Proteome variation among Filifactor alocis strains
Aruni, Proteomics 2012 - “...Nonsecretory 35. HMPREF0389_01465 Conserved hypothetical protein 41.5 29/0.13 4 C-7.5 EC-0.73 Hydrolase domain Nonsecretory 36. HMPREF0389_00744 Butryl coA dehydrogenase 41.25 11/0.07 2 C-7.5 EC-0.73 Acetyl coA DH1 and DH2 domain Nonsecretory 37. HMPREF0389_00745 Acetyl coA acetyl transfserase 40.9 51/0.07 9 C-7.2 EC-0.93 Thiolase 1,2,3 domain Nonsecretory...”
CLOSPO_02759 hypothetical protein from Clostridium sporogenes ATCC 15579
42% identity, 97% coverage
CLNEO_21740 acryloyl-CoA reductase from Anaerotignum neopropionicum
44% identity, 98% coverage
EHLA_0977 acyl-CoA dehydrogenase from Anaerobutyricum hallii
44% identity, 97% coverage
- Unravelling lactate-acetate and sugar conversion into butyrate by intestinal Anaerobutyricum and Anaerostipes species by comparative proteogenomics
Shetty, Environmental microbiology 2020 - “...between the two comparisons (including those encoded by genes with locus tags EHLA_0973, EHLA_0974, EHLA_0976, EHLA_0977, EHLA_0978, EHLA_0979) that were induced by growth on d , l lactate. Proteins with significantly higher abundance during growth on d , l lactate included lactate permease, lactate dehydrogenase, electron...”
E9PE82 short-chain acyl-CoA dehydrogenase from Homo sapiens
46% identity, 92% coverage
- Haptoglobin Induces a Specific Proteomic Profile and a Mature-Associated Phenotype on Primary Human Monocyte-Derived Dendritic Cells.
Torres, International journal of molecular sciences 2022 - “...cytoskeleton BZW2 Q75MG1 Basic leucine zipper and W2 domain-containing protein 2 E Cadherin binding ACADS E9PE82 Short-chain specific acyl-CoA dehydrogenase, mitochondrial E i. Acyl-CoA; butiryl-CoA dehydrogenase activity, ii. Flavin adenine dinucleotide binding CRYAB E9PR44 Alpha-crystallin B chain E i. Amyloid-beta; identical protein; metal ion; microtubule; and...”
- Effect of Inulin on Proteome Changes Induced by Pathogenic Lipopolysaccharide in Human Colon
Guarino, PloS one 2017 - “...Homo sapiens GN = EIF5A PE = 1 SV = 3 - [I3L397_HUMAN] 0,5 1,0 E9PE82 Short-chain-specific acyl-CoA dehydrogenase, mitochondrial OS = Homo sapiens GN = ACADS PE = 1 SV = 1 - [E9PE82_HUMAN] 0,5 1,0 Q6P996-3 Isoform 3 of Pyridoxal-dependent decarboxylase domain-containing protein 1...”
- Proteomics analyses for the global proteins in the brain tissues of different human prion diseases
Shi, Molecular & cellular proteomics : MCP 2015 - “...0.0180 21 P11766, F5GWH2, P42765, H0Y9U7, G3V1S9, Q92947, P49748, F5H0M0, P49189, P49419, P24752, C9JDE9, P30084, E9PE82, P40939, B4E2W0, P50416, B4DJE7, P05091, Q16836, P30837 5 Adipocytokine signaling pathway 0.02371 8 J3KPZ9, D7R525, F5GWH2, H0Y9U7, Q06124, G3V1S9, P42345, P50416 6 Butanoate metabolism a 0.02969 14 Q99259, P80404, P08559,...”
GJQ69_08630 acyl-CoA dehydrogenase from Caproicibacterium lactatifermentans
41% identity, 98% coverage
2dvlA / Q5SH14 Crystal structure of project tt0160 from thermus thermophilus hb8
50% identity, 97% coverage
- Ligand: flavin-adenine dinucleotide (2dvlA)
CPS_RS12125 acyl-CoA dehydrogenase family protein from Colwellia psychrerythraea 34H
46% identity, 98% coverage
CLNEO_29850 acyl-CoA dehydrogenase from Anaerotignum neopropionicum
41% identity, 96% coverage
HVO_2716 acyl-CoA dehydrogenase from Haloferax volcanii DS2
44% identity, 97% coverage
CD630_03990, CDIF630erm_00527 putative isocaproyl-CoA dehydrogenase AcdB from Clostridioides difficile 630
CD0399 acyl-CoA dehydrogenase, short-chain specific from Clostridium difficile 630
42% identity, 97% coverage
- Iron Regulation in Clostridioides difficile
Berges, Frontiers in microbiology 2018 - “...OFF -10.52 OFF CD630_03980 CDIF630erm_00526 hadC Oxygen-sensitive 2-hydroxyisocaproyl-CoA dehydratase subunit C -7.81 -4.86 -10.94 OFF CD630_03990 CDIF630erm_00527 acdB Acyl-CoA dehydrogenase -7.43 -4.27 -10.17 -4.76 CD630_04000 CDIF630erm_00528 etfB1 Electron transfer flavoprotein subunit beta -7.28 -3.90 -10.48 -4.50 CD630_04010 CDIF630erm_00529 etfA1 Electron transfer flavoprotein subunit alpha -7.50 -3.90...”
- “...-10.52 OFF CD630_03980 CDIF630erm_00526 hadC Oxygen-sensitive 2-hydroxyisocaproyl-CoA dehydratase subunit C -7.81 -4.86 -10.94 OFF CD630_03990 CDIF630erm_00527 acdB Acyl-CoA dehydrogenase -7.43 -4.27 -10.17 -4.76 CD630_04000 CDIF630erm_00528 etfB1 Electron transfer flavoprotein subunit beta -7.28 -3.90 -10.48 -4.50 CD630_04010 CDIF630erm_00529 etfA1 Electron transfer flavoprotein subunit alpha -7.50 -3.90 -10.39...”
- Global transcriptional control by glucose and carbon regulator CcpA in Clostridium difficile
Antunes, Nucleic acids research 2012 - “...expression of ldhA , hadA , hadI , acdB and etfB1 genes (CD0394, CD0395, CD0396, CD0399 and CD0400) required for the leucine reductive branch leading to the formation of isocaproate was 4-fold repressed by glucose by a CcpA-dependent mechanism ( Figure 7 ). We also identified...”
- “...ldhA (CD0394), 2-hydroxyisocaproate dehydrogenase; hadA (CD0395), 2-hydroxyisocaproate CoA transferase; hadI (CD0396), activator of dehydratase; acdB (CD0399), acyl-CoA dehydrogenase; gcvTPA (CD1657), bi-functional glycine dehydrogenase/aminomethyl transferase protein; gcvPB (CD1658), Glycine decarboxylase; CD1228, putative protease; CD3183, putative peptidase; CD2485, putative Xaa-Pro aminopeptidase; CD2347, putative Xaa-Pro dipeptidase; gcp (CD0152), putative...”
CG4860 uncharacterized protein from Drosophila melanogaster
45% identity, 89% coverage
- The MicroRNA miR-277 Controls Physiology and Pathology of the Adult Drosophila Midgut by Regulating the Expression of Fatty Acid β-Oxidation-Related Genes in Intestinal Stem Cells
Zipper, Metabolites 2022 - “...3 b). In detail, the reconstructed lineage towards pEC shows that FAO metabolic genes CG31075, CG4860, CG5599, CG9547, and whd diminish, while yip2 and CG3902 progressively increase ( Figure 3 b). Mtpalpha diminishes during the differentiation to then increase again in the terminally differentiated pEC (...”
- “...by high expression of the FAO genes CG5599, Mtpalpha , and yip2 and, respectively, CG3902, CG4860, CG9547, and whd in comparison to EB ( Figure 5 c). As an exception from miR-277 target genes showing clear expression differences among populations, CG31075 sticks out being high in...”
- Heritable shifts in redox metabolites during mitochondrial quiescence reprogramme progeny metabolism
Hocaoglu, Nature metabolism 2021 - “...Y ATP synthesis coupled proton transport ATP5ME CG8177 2.953726 3.75E-20 5.21E-18 Y bicarbonate transport SLC4A1 CG4860 2.023663 1.19E-11 7.01E-10 Y butyrate catabolic process ACADS AGBE 1.459516 7.63E-10 3.44E-08 Y carbohydrate metabolic process GBE1 CG2938 1.779595 3.50E-10 1.66E-08 Y carbohydrate metabolic process CASD1 CG10672 2.109713 4.03E-12 2.52E-10...”
- A second hybrid-binding domain modulates the activity of Drosophila ribonuclease H1
González, Journal of biochemistry 2020 - “...No No CG1236 CG1236 [Glyoxylate and hydroxypyruvate reductase], CG1236 GRHPR 2.6 Yes No No No CG4860 CG4860 [Short-chain acyl-CoA dehydrogenase], CG4860 ACADS 2.2 Yes No No No CG10194 CG10194, CG10194 NUDT19 2.2 Yes No No No CG5028 CG5028, [Isocitrate dehydrogenase (NAD(+))], isoform C, CG5028 IDH3G 2...”
- Rosy Beginnings: Studying Peroxisomes in Drosophila
Pridie, Frontiers in cell and developmental biology 2020 - “...PTS1 motif. Human Drosophila Function Function Loc ACAA1 CG9149 -Oxidation -Ketoacyl-CoA thiolase () B ACAD11 CG4860 -Oxidation Short-chain acyl-CoA dehydrogenase () B ACOX2 CG17544 -Oxidation Acyl-CoA oxidase (+) B ACSL1 CG3961 -Oxidation Long-chain-fatty-acidCoA ligase () B ACSL3/4 Acsl -Oxidation Acyl-CoA synthetase long-chain () B (+) H...”
- Natural Genetic Variation Screen in Drosophila Identifies Wnt Signaling, Mitochondrial Metabolism, and Redox Homeostasis Genes as Modifiers of Apoptosis
Palu, G3 (Bethesda, Md.) 2019 - “...additional 4 genes involved in mitochondrial -oxidation: wal ( ETFA ), Mcad ( ACADM ), CG4860 ( ACADS ), and CG7461 ( ACADVL ). The involvement of enzymes regulating redox homeostasis, and more specifically redox homeostasis in the mitochondria, is consistent with rpr -induced apoptosis. Both...”
- Evidence that microRNAs are part of the molecular toolkit regulating adult reproductive diapause in the mosquito, Culex pipiens
Meuti, PloS one 2018 - “...CG3902 CPIJ009148 miR-277 CG2118 CPIJ003841 miR-277 CG5044 CPIJ012030 miR-277 yip2 CPIJ002342 miR-277 CG6638 CPIJ014783 miR-277 CG4860 CPIJ011633 miR-277 CG1673 CPIJ015408 miR-277 CG6543 CPIJ006455 CPIJ014621 miR-277 CG8778 CPIJ016903 CPIJ006767 CPIJ019824 miR-277 CG3267 CPIJ009999 miR-277 CG10932 CPIJ019232 miR-277 CG12262 CPIJ008217 miR-305 CG30463 CPIJ005695 miR-124 Fatty acid elongation 8.03E-09...”
- “...miR-277 CG16935 CPIJ014619 CPIJ006453 miR-13b Fatty acid degradation 3.52E-06 CG3902 CPIJ009148 miR-277 yip2 CPIJ002342 miR-277 CG4860 CPIJ011633 miR-277 CG6543 CPIJ006455 CPIJ014621 miR-277 CG9547 CPIJ000375 miR-277 CG10932 CPIJ019232 miR-277 CG12262 CPIJ008217 miR-305-5p Propanoate metabolism 4.51E-06 CG17896 CPIJ009984 miR-277 CG5044 CPIJ012030 miR-277 CG6543 CPIJ006455 CPIJ014621 miR-277 ACC CPIJ005524...”
- Neuronal remodeling during metamorphosis is regulated by the alan shepard (shep) gene in Drosophila melanogaster
Chen, Genetics 2014 - “...BG00476 Shal K+ channel interacting protein (SKIP) jim CG4860 Trapped gene(s) BG00076 Transposon insertion First intron First exon of RA and RE; second intron...”
- Genome-wide P-element screen for Drosophila synaptogenesis mutants
Liebl, Journal of neurobiology 2006 - “...difference in transcript size: mael, CG8545, CG8351, and CG4860. This supports the idea that lethality in many Gene Disruption Project P-element mutants is due...”
- “...Overgrowth Overgrowth Overgrowth Other Overgrowth Overgrowth CG4860 sgl l(2)35Di Mrps6 Gyc76C CG8552 Cop Scim15 Hr39 Df(3R)E79 Df(3L)XDI98 Df(2L)osp29...”
KR505_02675 acyl-CoA dehydrogenase family protein from Eubacterium callanderi
43% identity, 98% coverage
- Gut Microbiota Eubacterium callanderi Exerts Anti-Colorectal Cancer Activity
Ryu, Microbiology spectrum 2022 - “...to butyric acid biosynthesis. But , butyryl-CoA:acetate CoA transferase (locus_tag, KR505_02670); Bcd , butyryl-CoA dehydrogenase (KR505_02675, KR505_10030); ETF , electron transfer flavoprotein subunit alpha (KR505_10020); ETF , electron transfer flavoprotein subunit beta (KR505_10025); Hbd , hydroxybutyryl dehydrogenase (KR505_10035); Cro , crotonase/enoyl-CoA hydratase (KR505_10040); Thl , acetyl-CoA...”
Swol_0788 Butyryl-CoA dehydrogenase from Syntrophomonas wolfei subsp. wolfei str. Goettingen
43% identity, 98% coverage
- Stimulating Effect of Trichococcus flocculiformis on a Coculture of Syntrophomonas wolfei and Methanospirillum hungatei
Doloman, Applied and environmental microbiology 2022 - “...tri-culture conditions, in addition to the other butyryl-CoA dehydrogenases under bi- or triculture conditions (Swol_2052, Swol_0788, Swol_0488, and Swol_1841) (see Table S1). Increased butyrate oxidation by S. wolfei might be also partially influenced by the more active hydrogen scrubbing by the methanogens, which in turn might...”
- Involvement of NADH:acceptor oxidoreductase and butyryl coenzyme A dehydrogenase in reversed electron transport during syntrophic butyrate oxidation by Syntrophomonas wolfei
Müller, Journal of bacteriology 2009 - “...presumed operons with other butyryl-metabolic genes (e.g., Swol_0788, Swol_ 1483, and Swol_1933 [not shown]). The soluble protein frac- Downloaded from...”
CLNEO_26130 acyl-CoA dehydrogenase family protein from Anaerotignum neopropionicum
42% identity, 97% coverage
ACDS_MEGEL / Q06319 Acyl-CoA dehydrogenase, short-chain specific; Butyryl-CoA dehydrogenase; BCAD; SCAD; EC 1.3.8.1 from Megasphaera elsdenii (see paper)
1bucA / Q06319 Three-dimensional structure of butyryl-coa dehydrogenase from megasphaera elsdenii (see paper)
GI|149886 butyryl-CoA dehydrogenase; EC 1.3.99.2 from Megasphaera elsdenii (see 2 papers)
43% identity, 97% coverage
- function: Has an optimum specificity for 4-carbon length fatty acyl- CoAs.
catalytic activity: butanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein] (RHEA:24004)
catalytic activity: a short-chain 2,3-saturated fatty acyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = a short-chain (2E)-enoyl- CoA + reduced [electron-transfer flavoprotein] (RHEA:47196)
cofactor: FAD
subunit: Homotetramer - Ligands: acetoacetyl-coenzyme a; flavin-adenine dinucleotide (1bucA)
- New perspectives on butyrate assimilation in Rhodospirillum rubrum S1H under photoheterotrophic conditions
De, BMC microbiology 2020 - “...acetobutylicum [ 19 ] (accession number P52042) or Megasphaera elsdenii [ 20 ] (accession number Q06319). As already described in Desulfosarcina cetonica [ 4 ] in the context of butyrate catabolism, crotonyl-CoA is proposed to be further transformed into acetyl-CoA (Fig. 2 ). It is first...”
- Characterization and overproduction of cell-associated cholesterol oxidase ChoD from Streptomyces lavendulae YAKB-15
Yamada, Scientific reports 2019 - “...PadR, Bacillus subtilis 96/28 P94443 5 ORF B 574 Acyl-CoA dehydrogenase Scad, Megasphaera elsdenii 33/27 Q06319 6 ORF C 226 Methyltransferase BQ2027_MB0092, Mycobacterium bovis 49/40 P65347 Enzyme kinetics of recombinant ChoD In order to characterize ChoD, we ordered a synthetic gene codon optimized for expression in...”
- Mycobacterium tuberculosis utilizes a unique heterotetrameric structure for dehydrogenation of the cholesterol side chain
Thomas, Biochemistry 2013 - “...GD (Q92947), VLCAD (P49748), ACAD9 (Q9H845), ACAD10 (Q6JQN1), ACAD11 (Q709F0), 1BUC (SCAD Megasphaera elsdenii , Q06319), 3NF4 ( Mycobacterium thermoresistibile , G7CDN2). Residues in green bind the isoalloxazine and ribityl diphosphate moieties of FAD, residues in blue bind adenosine of FAD, residues in purple bind CoA,...”
CARC_ACEWD / H6LGM6 Caffeyl-CoA reductase-Etf complex subunit CarC; Caffeoyl-CoA reductase CarC; NADH-dependent caffeyl-CoA reduction; EC 1.3.1.108 from Acetobacterium woodii (strain ATCC 29683 / DSM 1030 / JCM 2381 / KCTC 1655 / WB1) (see paper)
H6LGM6 caffeoyl-CoA reductase (subunit 3/3) (EC 1.3.1.108) from Acetobacterium woodii (see paper)
6fahD / H6LGM6 Molecular basis of the flavin-based electron-bifurcating caffeyl-coa reductase reaction (see paper)
Awo_c15720 caffeyl-CoA reductase-Etf complex subunit CarC from Acetobacterium woodii DSM 1030
40% identity, 97% coverage
- function: The Caffeyl-CoA reductase-Etf complex catalyzes the reduction of caffeyl-CoA to yield hydrocaffeyl-CoA. It couples the endergonic ferredoxin reduction with NADH as reductant to the exergonic reduction of caffeoyl-CoA with the same reductant. It uses the mechanism of electron bifurcation to overcome the steep energy barrier in ferredoxin reduction. Also reduces 4-coumaroyl-CoA and feruloyl-CoA.
catalytic activity: hydrocaffeoyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 NAD(+) = (E)-caffeoyl-CoA + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 NADH (RHEA:46956)
cofactor: FAD (Binds 1 or 2 FAD per subunit.)
subunit: Part of the homotrimeric caffeyl-CoA reductase-Etf complex composed of (R)-2-hydroxyisocaproyl-CoA dehydratase CarC, and the electron transfer flavoprotein (ETF) alpha (CarE) and beta (CarD) subunits. - Ligand: flavin-adenine dinucleotide (6fahD)
- A new metabolic trait in an acetogen: Mixed acid fermentation of fructose in a methylene-tetrahydrofolate reductase mutant of Acetobacterium woodii
Moon, Environmental microbiology reports 2023 - “...Propionate CoAtransferase CarA Caffeate metabolism 1041 54 4.27 Awo_c15710 FattyacylCoA synthase CarB 1188 46 4.69 Awo_c15720 AcylCoA dehydrogenase CarC 1006 59 4.09 Awo_c15730 Electron transfer flavoprotein beta subunit CarD 1220 52 4.55 Awo_c15740 Electron transfer flavoprotein alpha subunit apoprotein CarE 2209 125 4.14 Awo_c24340 Alanine or...”
2d29A / Q5SGZ2 Structural study on project id tt0172 from thermus thermophilus hb8
47% identity, 97% coverage
- Ligand: flavin-adenine dinucleotide (2d29A)
acdA / J7TF92 cinnamate reductase monomer (EC 1.3.8.15) from Clostridium sporogenes (strain ATCC 15579) (see 6 papers)
ACDA_CLOS1 / J7TF92 3-(aryl)acrylate reductase; EC 1.3.8.15 from Clostridium sporogenes (strain ATCC 15579) (see paper)
J7TF92 3-(aryl)acrylate reductase (EC 1.3.8.15) from Clostridium sporogenes (see paper)
CLOSPO_00312 hypothetical protein from Clostridium sporogenes ATCC 15579
42% identity, 97% coverage
- function: Essential for the reductive metabolism of L-phenylalanine, L- tyrosine and L-tryptophan (PubMed:29168502). Catalyzes the reduction of phenylacrylic acid to phenylpropionic acid, 4-hydroxy-phenylacrylic acid to 4-hydroxy-phenylpropionic acid, and indoleacrylic acid to indolepropionic acid (PubMed:29168502).
catalytic activity: 3-phenylpropanoate + oxidized [electron-transfer flavoprotein] + H(+) = (E)-cinnamate + reduced [electron-transfer flavoprotein] (RHEA:59996)
catalytic activity: phloretate + oxidized [electron-transfer flavoprotein] + H(+) = (E)-4-coumarate + reduced [electron-transfer flavoprotein] (RHEA:59992)
catalytic activity: indole-3-propanoate + oxidized [electron-transfer flavoprotein] + H(+) = (E)-3-(indol-3-yl)acrylate + reduced [electron-transfer flavoprotein] (RHEA:60104)
cofactor: FAD
disruption phenotype: Mutants are deficient in reductive metabolism of phenylalanine, tyrosine and tryptophan, and exhibit growth defects when cultured with amino acids as the sole carbon source. - Linking microbial genes to plasma and stool metabolites uncovers host-microbial interactions underlying ulcerative colitis disease course
Schirmer, Cell host & microbe 2024 (secret) - A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites
Dodd, Nature 2017 - “...action of acyl-CoA transferase (FldA, CLOSPO_00308). Finally, the arylacrylates are reduced by acyl-CoA dehydrogenase (AcdA, CLOSPO_00312) involving its two electron transport factors (EtfA-EtfB, CLOSPO_00313-314). For the oxidative pathway, phenylpyruvate and 4-OH-phenylpyruvate are first oxidatively decarboxylated by pyruvate:ferredoxin oxidoreductase A (PorA, CLOSPO_00147-149), followed by phosphate acyltransferase and...”
CBO3288 acyl-CoA dehydrogenase from Clostridium botulinum A str. ATCC 3502
42% identity, 97% coverage
- Transcriptomic analysis of (group I) Clostridium botulinum ATCC 3502 cold shock response
Dahlsten, PloS one 2014 - “...cbo3544 [ prsA ]), energy metabolism ( cbo1489 , cbo1498 , cbo3242 , cbo3244 , cbo3288 [ acdA ]), transcription or translation ( cbo2434 [ tsf ], cbo2939 [ dnaG ]), cobalamin biosynthesis ( cbo0410 , cbo0914-cbo0916 [ cobQ-cbiB-cobD ]), or cell wall synthesis ( cbo0791...”
Gmet_1710 Acyl-CoA dehydrogenase-like from Geobacter metallireducens GS-15
44% identity, 97% coverage
- Genome sequence of a dissimilatory Fe(III)-reducing bacterium Geobacter soli type strain GSS01(T)
Yang, Standards in genomic sciences 2015 - “...are predicted from the genome of G. soli : acyl-CoA dehydrogenase (SE37_11155, 80% similarity to Gmet_1710 in G. metallireducens ; SE37_11180, 86% similarity to that of Geoalkalibacter subterraneus ), succinyl-CoA:acetate CoA-transferases (SE37_00360; SE37_11235, 83% similarity to Gbem_2843 in G. bemidjiensis ; SE37_13685), acyl-CoA thioesterases (SE37_09325, SE37_09950,...”
CPE0097 acyl-CoA dehydrogenase from Clostridium perfringens str. 13
41% identity, 98% coverage
Acfer_1583 acyl-CoA dehydrogenase domain protein from Acidaminococcus fermentans DSM 20731
41% identity, 98% coverage
- Complete genome sequence of Acidaminococcus fermentans type strain (VR4)
Chang, Standards in genomic sciences 2010 - “...encoded at the beginning of the gene cluster. Three acyl-CoA dehydrogenase genes (Acfer_1477, Acfer_1575 and Acfer_1583) were annotated at various locations, completing the pathway. Nevertheless, genes encoding 2-hydroxyglutarate dehydrogenase and Butyl-CoA:acetate CoA transferase have not yet been identified. Possibly these enzymes have additional functions in other...”
- “...decarboxylase sodium pump, subunit r Acfer_1477 acyl-CoA dehydrogenase domain protein Acfer_1575 acyl-CoA dehydrogenase domain protein Acfer_1583 acyl-CoA dehydrogenase domain protein Enzymes of -lactamase and the related Acfer_0250 -lactamase domain-containing protein Acfer_0522 Zn-dependent hydrolase of the -lactamase fold Acfer_0551 RNA-metabolizing metallo--lactamase Acfer_0879 -lactamase class A-like Acfer_1020 RNA-metabolizing...”
C6369_RS07820 acyl-CoA dehydrogenase family protein from Rhodococcus rhodochrous
43% identity, 97% coverage
- Catabolism of Alkylphenols in Rhodococcus via a Meta-Cleavage Pathway Associated With Genomic Islands
Levy-Booth, Frontiers in microbiology 2019 - “...pathway (Jimenez-Diaz et al., 2017 ) encoded by butyryl-CoA dehydrogenase genes (locus tags: C6369_RS06395, C6369_RS20140, C6369_RS07820, C6369_RS05465), enoylCoA hydratase (C6369 _RS19405, C6369_RS19860), 3-hydroxybutyryl-CoA dehydrogenase (C6369_RS03325, C6369_RS06400), and acetyl-CoA acyltransferase (C6369_RS17095, C6369_RS15900, C6369_RS19850) ( Supplementary Figure 2 ). The catABC cluster encoding catechol 1,2-dioxygenase and other enzymes...”
7szvA / A0A3E2MWC7 Crystal structure of acyl-coa dehydrogenase from mycobacterium marinum in complex with fda
43% identity, 97% coverage
- Ligand: dihydroflavine-adenine dinucleotide (7szvA)
CLOAM1274 Acyl-CoA dehydrogenase from Candidatus Cloacamonas acidaminovorans
42% identity, 98% coverage
- A novel acyl-CoA beta-transaminase characterized from a metagenome
Perret, PloS one 2011 - “...bifurcation [21] , [22] . The genome of Candidatus Cloacamonas acidaminovorans contains good candidate genes (CLOAM1274, 1482, and 0104) coding for a butyryl-CoA dehydrogenase/electron-transferring-flavoprotein complex (Bcd/EtfAB). However, the formation of crotonyl-CoA from acetoacetyl-CoA or other metabolites remains enigmatic, because no genes coding for 3-hydroxybutyryl-CoA dehydrogenase (EC...”
2jifA / P45954 Structure of human short-branched chain acyl-coa dehydrogenase (acadsb)
39% identity, 97% coverage
- Ligands: flavin-adenine dinucleotide; coenzyme a persulfide (2jifA)
F1SED0 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial from Sus scrofa
39% identity, 87% coverage
ACADSB / P45954 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial (EC 1.3.8.5) from Homo sapiens (see 4 papers)
ACDSB_HUMAN / P45954 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial; SBCAD; 2-methyl branched chain acyl-CoA dehydrogenase; 2-MEBCAD; 2-methylbutyryl-coenzyme A dehydrogenase; 2-methylbutyryl-CoA dehydrogenase; EC 1.3.8.5 from Homo sapiens (Human) (see 7 papers)
NP_001600 short/branched chain specific acyl-CoA dehydrogenase, mitochondrial isoform 1 precursor from Homo sapiens
39% identity, 86% coverage
- function: Short and branched chain specific acyl-CoA dehydrogenase that catalyzes the removal of one hydrogen from C-2 and C-3 of the fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (PubMed:10832746, PubMed:11013134, PubMed:21430231, PubMed:7698750). Among the different mitochondrial acyl-CoA dehydrogenases, acts specifically on short and branched chain acyl-CoA derivatives such as (S)-2-methylbutyryl-CoA as well as short straight chain acyl-CoAs such as butyryl-CoA (PubMed:10832746, PubMed:11013134, PubMed:21430231, PubMed:7698750). Plays an important role in the metabolism of L- isoleucine by catalyzing the dehydrogenation of 2-methylbutyryl-CoA, one of the steps of the L-isoleucine catabolic pathway (PubMed:10832746, PubMed:11013134). Can also act on valproyl-CoA, a metabolite of valproic acid, an antiepileptic drug (PubMed:8660691).
catalytic activity: 2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein] (RHEA:43780)
catalytic activity: (2S)-2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein] (RHEA:48256)
catalytic activity: (2R)-2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = ethylacryloyl-CoA + reduced [electron-transfer flavoprotein] (RHEA:65296)
catalytic activity: butanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein] (RHEA:24004)
catalytic activity: 2-methylpropanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein] (RHEA:44180)
catalytic activity: hexanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein] (RHEA:43464)
catalytic activity: 2-methylhexanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = 2-methylhexenoyl-CoA + reduced [electron- transfer flavoprotein] (RHEA:48272)
catalytic activity: valproyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-propylpent-2-enoyl-CoA + reduced [electron-transfer flavoprotein] (RHEA:65344)
cofactor: FAD
subunit: Homotetramer. - Lipid Metabolism Pathway Genes and Lung Cancer: ACADSB rs12220683G>C Is Associated with Better Survival Outcome in Patients with Non-Small Cell Lung Cancer.
Yoo, Oncology 2024 (PubMed)- GeneRIF: Lipid Metabolism Pathway Genes and Lung Cancer: ACADSB rs12220683G>C Is Associated with Better Survival Outcome in Patients with Non-Small Cell Lung Cancer.
- ACADSB regulates ferroptosis and affects the migration, invasion, and proliferation of colorectal cancer cells.
Lu, Cell biology international 2020 (PubMed)- GeneRIF: ACADSB regulates ferroptosis and affects the migration, invasion, and proliferation of colorectal cancer cells.
- Clinical, biochemical, and molecular spectrum of short/branched-chain acyl-CoA dehydrogenase deficiency: two new cases and review of literature.
Porta, Journal of pediatric endocrinology & metabolism : JPEM 2019 (PubMed)- GeneRIF: ACADSB mutation is associated with short/branched-chain acyl-CoA dehydrogenase deficiency.
- Molecular diagnosis of infantile mitochondrial disease with targeted next-generation sequencing.
Calvo, Science translational medicine 2012 - GeneRIF: Strong candidate gene for mitochondrial disease, based on recessive mutations detected in infantile patients
- Genome-wide association study of circulating vitamin D levels.
Ahn, Human molecular genetics 2010 - GeneRIF: Observational study, meta-analysis, and genome-wide association study of gene-disease association. (HuGE Navigator)
- Characterization of new ACADSB gene sequence mutations and clinical implications in patients with 2-methylbutyrylglycinuria identified by newborn screening.
Alfardan, Molecular genetics and metabolism 2010 - GeneRIF: These findings confirm that SBCAD deficiency can be identified through newborn screening by acylcarnitine analysis.
- Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson, PloS one 2010 - GeneRIF: Observational study of gene-disease association. (HuGE Navigator)
- Association of genetic polymorphisms of ACADSB and COMT with human hypertension.
Kamide, Journal of hypertension 2007 (PubMed)- GeneRIF: Observational study of gene-disease association. (HuGE Navigator)
- More
- Insight into the Molecular Signature of Skeletal Muscle Characterizing Lifelong Football Players
Orrù, International journal of environmental research and public health 2022 - “...protein OPA3 1.85 Q15124 Phosphoglucomutase-like protein 5 PGM5 1.85 Q02224 Centromere-associated protein E CENPE 1.85 P45954 Short/branched chain-specific acyl-CoA dehydrogenase, mitochondrial ACADSB 1.85 Q9H0P0 Cytosolic 5-nucleotidase 3 NT5C3A 1.76 P10809 60 kDa Heat shock protein, mitochondrial HSPD1 1.76 P56134 ATP synthase subunit f, mitochondrial ATP5J2 1.64...”
- HSP60 Regulates Lipid Metabolism in Human Ovarian Cancer
Li, Oxidative medicine and cellular longevity 2021 - “...sapiens GN=ACADS PE=2 SV=1[D4QEZ8_HUMAN] ACADS 27.67 8 8 19 44.33 7.72 1.33 6.43 E 06 P45954 Short/branched chain-specific acyl-CoA dehydrogenase, mitochondrial OS=Homo sapiens GN=ACADSB PE=1 SV=1[ACDSB_HUMAN] ACADSB 25.93 8 8 15 47.46 6.99 1.29 1.06 E 02 Q08426 Peroxisomal bifunctional enzyme OS=Homo sapiens GN=EHHADH PE=1 SV=3[ECHP_HUMAN]...”
- “...sapiens GN=ACADS PE=2 SV=1[D4QEZ8_HUMAN] ACADS 27.67 8 8 19 44.33 7.72 1.33 6.43 E 06 P45954 Short/branched chain-specific acyl-CoA dehydrogenase, mitochondrial OS=Homo sapiens GN=ACADSB PE=1 SV=1[ACDSB_HUMAN] ACDSB 25.93 8 8 15 47.46 6.99 1.29 1.06 E 02 A0A024R8L7 Acyl-coenzyme A oxidase OS=Homo sapiens GN=ACOX1 PE=3 SV=1[A0A024R8L7_HUMAN]...”
- Electron transfer flavoprotein and its role in mitochondrial energy metabolism in health and disease.
Henriques, Gene 2021 - “...dehydrogenase family member 11 ACAD11 Q709F0 n.d. C22-CoA SBCAD Short/branched chain specific acyl-CoA dehydrogenase ACADSB P45954 Amino acid catabolism, fatty acid oxidation 2-methylbutyryl-CoA, isobutyryl-CoA, 2-methylhexanoyl-CoA, C4-CoA and C8-CoA GCDH Glutaryl-CoA dehydrogenase GCDH Q92947 Amino acid catabolism glutaryl-CoA IBDH Isobutyryl-CoA dehydrogenase ACAD8 Q9UKU7 Amino acid catabolism 2-methylbutanoyl-CoA...”
- Identification of HO-1 as a novel biomarker for graft acute cellular rejection and prognosis prediction after liver transplantation
Jia, Annals of translational medicine 2020 - “...Alcohol dehydrogenase 1B ADH1B 0.543 Q96F10 Diamine acetyltransferase 2 SAT2 0.548 P36871 Phosphoglucomutase-1 PGM1 0.548 P45954 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.549 P54840 Glycogen (starch) synthase, liver GYS2 0.557 O95563 Mitochondrial pyruvate carrier 2 MPC2 0.559 Q9UBQ7 Glyoxylate reductase/hydroxypyruvate reductase GRHPR 0.561 P07108 Acyl-CoA-binding...”
- Proteomic Analysis of Renal Biomarkers of Kidney Allograft Fibrosis-A Study in Renal Transplant Patients.
Mortensen, International journal of molecular sciences 2020 - “...25.7 5.8 1.54 10 -4 4.11 10 -1 0 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial P45954 26.9 6.1 1.58 10 -4 4.20 10 -1 0 X-ray repair cross-complementing protein 6 P12956 40.2 9.1 1.63 10 -4 4.33 10 -1 0 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial Q13011 37.2 8.5...”
- Transcriptome analysis of genes and pathways associated with metabolism in Scylla paramamosain under different light intensities during indoor overwintering.
Li, BMC genomics 2020 - “...Q16836 0.4400 0.0349 0.3574 0.0132 Fatty acid degradation (ko00071) Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial P45954 0.5031 0.0261 Aldehyde dehydrogenase family 9 member A1-A Q7ZVB2 0.4922 0.0255 Enoyl-CoA delta isomerase 2 Q9WUR2 0.4154 0.0024 Glutaryl-CoA dehydrogenase Q2KHZ9 0.5238 0.0112 Long-chain specific acyl-CoA dehydrogenase P51174 0.5771 0.0348...”
- Application of Bioactive Thermal Proteome Profiling to Decipher the Mechanism of Action of the Lipid Lowering 132-Hydroxy-pheophytin Isolated from a Marine Cyanobacteria.
Carrasco, Marine drugs 2019 - “...1 49.21 50.48 49.08 49.30 0.8192 P30038 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 42.97 44.66 42.77 43.22 0.9284 P45954 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial 45.27 47.28 44.85 46.52 0.7475 P60709 * Actin, cytoplasmic 1 44.10 48.42 41.84 45.14 0.0455 Q06210 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 47.31 48.12 47.14 47.55...”
- Proteomic analyses identify prognostic biomarkers for pancreatic ductal adenocarcinoma.
Hu, Oncotarget 2018 - “...molecule Q96LJ7 DHRS1 7 1 0.007 0.24 1 0.017 0.37 Dehydrogenase/reductase SDR family member 1 P45954 ACADSB 9 3 0.017 0.15 2 0.026 0.38 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial Q96IU4 ABHD14B 10 9 0.007 0.31 2 0.013 0.46 Alpha/beta hydrolase domain-containing protein 14B Q6UXI9-6 NPNT...”
- More
DDB_G0282967 acyl-CoA dehydrogenase from Dictyostelium discoideum AX4
38% identity, 91% coverage
AR1Y2_1117 acyl-CoA dehydrogenase family protein from Anaerostipes rhamnosivorans
42% identity, 97% coverage
- Conversion of dietary inositol into propionate and acetate by commensal Anaerostipes associates with host health
Bui, Nature communications 2021 - “...AR1Y2_1115), an enoyl-CoA dehydratase (AcaD encoded by AR1Y2_1116) and an acyl dehydrogenase (EcdH encoded by AR1Y2_1117) and acyl dehydrogenase complex (AcaD-Etf encoded by AR1Y2_1050-1052). CO 2 /H 2 or formate is also formed from a conversion of pyruvate to acetyl-CoA involved pyruvate-flavodoxin oxidoreductase (Por encoded by...”
- “...rhamnose. These included 3-oxoacid CoA transferase (OxcT encoded by AR1Y2_1115), acyl-CoA dehydrogenase (AcaD encoded by AR1Y2_1117), enoyl-CoA hydratase (EcdH encoded by AR1Y2_1116) and acryloyl-CoA dehydrogenase/Etf (AcaD-Etf encoded by AR1Y2_1050-1052 ) . Interestingly, oxcT, ecdH and acaD (AR1Y2_1115-1117) were located in a putative operon. The 3-oxoacid CoA...”
DR_1544 acyl-CoA dehydrogenase from Deinococcus radiodurans R1
42% identity, 88% coverage
CPI83_20015 acyl-CoA dehydrogenase family protein from Rhodococcus sp. H-CA8f
43% identity, 96% coverage
TTHB022 putative acyl-CoA dehydrogenase from Thermus thermophilus HB8
45% identity, 97% coverage
W5PUC2 short-chain acyl-CoA dehydrogenase from Ovis aries
44% identity, 93% coverage
Q1CZW5 Acyl-CoA dehydrogenase from Myxococcus xanthus (strain DK1622)
40% identity, 95% coverage
- Proteome Analyses of Soil Bacteria Grown in the Presence of Potato Suberin, a Recalcitrant Biopolymer
Sidibé, Microbes and environments 2016 - “...E Q1D5V2 3-oxoacid CoA-transferase 0.07 I Q1D855 long-chain-fatty-acid-CoA ligase 0.02 I Q1D566 acyltransferase 0.02 I Q1CZW5 acyl-CoA dehydrogenase 0.02 0.02 I Q1D003 -ketothiolase 0.02 0.13 I A0A0H4WWQ8 acyl-CoA dehydrogenase 0.02 I a Data are the mean of two replicates. b E: extracellular; I: intracellular. c :...”
- “...I4WM78 a , M4NHA9 a , I4W091 b Q1D3D6, Q1D4E4 b , Q1D5Y1 b , Q1CZW5, A0A0H4WWQ8 enoyl-CoA hydratase I4WR77 b , I4WPL0 Q1D5U2 b 3-hydroxyacyl-CoA dehydrogenase I4WIC4, I4VRU7 a Q1D5U1 b , Q1D233 b acetyl-CoA acetyltransferase I4WBZ6, I4WIC3 Q1D5VO, Q1D234 b , BKT b ,...”
LOC118276297 short/branched chain specific acyl-CoA dehydrogenase, mitochondrial from Spodoptera frugiperda
41% identity, 89% coverage
- Genome-Wide Identification and Expression Profiling of Candidate Sex Pheromone Biosynthesis Genes in the Fall Armyworm (Spodoptera frugiperda)
Qu, Insects 2022 - “...99.02 SfruACD2 LOC118264809 410 NC_049715.1 14,866,408 14,875,265 acyl-CoA dehydrogenase QZC92122.1 Dioryctria abietella 0.0 72.68 SfruACD3 LOC118276297 418 NC_049731.1 13,012,363 13,027,495 short/branched-chain specific acyl-CoA dehydrogenase, mitochondrial XP_022827910.1 Spodoptera litura 0.0 99.28 SfruACD4 LOC118265626 422 NC_049710.1 13,581,976 13,599,130 putative medium-chain specific acyl-CoA dehydrogenase AID66670.1 Agrotis segetum 0.0 96.45...”
GAH_02050 acyl-CoA dehydrogenase family protein from Geoglobus ahangari
41% identity, 98% coverage
- The complete genome sequence and emendation of the hyperthermophilic, obligate iron-reducing archaeon "Geoglobus ahangari" strain 234(T)
Manzella, Standards in genomic sciences 2015 - “...are putatively encoded by 11 genes (GAH_00179, GAH_00421, GAH_00484, GAH_00591, GAH_01331, GAH_01442, GAH_01601, GAH_01810, and GAH_02050). A water molecule is then added to trans-2-enoyl-CoA to form (3S)-3-hydroxyacyl-CoA in a reaction catalyzed by an enoyl-CoA hydratase, which in G. ahangari could be encoded by 4 genes (GAH_00487,...”
MSMEG_4715 acyl-CoA dehydrogenase from Mycobacterium smegmatis str. MC2 155
44% identity, 96% coverage
D0N7Z2 short-chain 2-methylacyl-CoA dehydrogenase from Phytophthora infestans (strain T30-4)
41% identity, 91% coverage
NP_001037672 acyl-coenzyme A dehydrogenase from Bombyx mori
40% identity, 88% coverage
SE37_11155 acyl-CoA dehydrogenase family protein from Geobacter soli
44% identity, 97% coverage
An01g12960 uncharacterized protein from Aspergillus niger
41% identity, 85% coverage
Q65Y10 short-chain acyl-CoA dehydrogenase (EC 1.3.8.1) from Butyrivibrio fibrisolvens (see paper)
42% identity, 97% coverage
Swol_0488 Butyryl-CoA dehydrogenase from Syntrophomonas wolfei subsp. wolfei str. Goettingen
40% identity, 97% coverage
- Dynamic acylome reveals metabolite driven modifications in Syntrophomonas wolfei
Fu, Frontiers in microbiology 2022 - “...steps in -oxidation and are as follows: acyl-CoA transferase (Swol_0309, 1014, 1147, 2128), acyl-CoA dehydrogenase (Swol_0488, 0788, 1841), enoyl-CoA hydratase (Swol_0790, 2031, 2129), 3- hydroxybutyryl-CoA dehydrogenase (Swol_0307, 0791, 1171), and acetyl-CoA acetyltransferase (Swol_0308, 0789). Our improved proteomic depth revealed additional -oxidation paralogs and led us to...”
- Stimulating Effect of Trichococcus flocculiformis on a Coculture of Syntrophomonas wolfei and Methanospirillum hungatei
Doloman, Applied and environmental microbiology 2022 - “...conditions, in addition to the other butyryl-CoA dehydrogenases under bi- or triculture conditions (Swol_2052, Swol_0788, Swol_0488, and Swol_1841) (see Table S1). Increased butyrate oxidation by S. wolfei might be also partially influenced by the more active hydrogen scrubbing by the methanogens, which in turn might be...”
LOC409712 short/branched chain specific acyl-CoA dehydrogenase, mitochondrial from Apis mellifera
39% identity, 90% coverage
Acadsb / P70584 2-methyl branched chain acyl-CoA dehydrogenase subunit (EC 1.3.8.5) from Rattus norvegicus (see 2 papers)
ACDSB_RAT / P70584 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial; SBCAD; 2-methyl branched chain acyl-CoA dehydrogenase; 2-MEBCAD; 2-methylbutyryl-coenzyme A dehydrogenase; 2-methylbutyryl-CoA dehydrogenase; EC 1.3.8.5 from Rattus norvegicus (Rat) (see 3 papers)
39% identity, 86% coverage
- function: Short and branched chain specific acyl-CoA dehydrogenase that catalyzes the removal of one hydrogen from C-2 and C-3 of the fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (PubMed:12855692, PubMed:6874697, PubMed:8660691). Among the different mitochondrial acyl-CoA dehydrogenases, acts specifically on short and branched chain acyl-CoA derivatives such as (S)-2-methylbutyryl-CoA as well as short straight chain acyl-CoAs such as butyryl-CoA (PubMed:12855692, PubMed:6874697, PubMed:8660691). Plays an important role in the metabolism of L-isoleucine by catalyzing the dehydrogenation of 2-methylbutyryl-CoA, one of the steps of the L- isoleucine catabolic pathway (By similarity). Can also act on valproyl- CoA, a metabolite of the valproic acid drug (PubMed:8660691).
catalytic activity: 2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein] (RHEA:43780)
catalytic activity: (2S)-2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein] (RHEA:48256)
catalytic activity: (2R)-2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = ethylacryloyl-CoA + reduced [electron-transfer flavoprotein] (RHEA:65296)
catalytic activity: butanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein] (RHEA:24004)
catalytic activity: 2-methylpropanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein] (RHEA:44180)
catalytic activity: hexanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein] (RHEA:43464)
catalytic activity: valproyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-propylpent-2-enoyl-CoA + reduced [electron-transfer flavoprotein] (RHEA:65344)
cofactor: FAD
subunit: Homotetramer. - Hyperoside attenuates non-alcoholic fatty liver disease in rats via cholesterol metabolism and bile acid metabolism.
Wang, Journal of advanced research 2021 - “...Fatty acid degradation P23965 ECI1, DCI 14 14 1 48.1 Delta3-Delta2-enoyl-CoA isomerase [EC:5.3.3.8] 1.19 0.0145 P70584 ACADSB 15 15 15 51.2 Short/branched chain acyl-CoA dehydrogenase [EC:1.3.99.12] 1.36 0.0281 A1L128 Adh4 19 4 4 81.2 Alcohol dehydrogenase 4 [EC:1.1.1.1] 1.83 0.0005 Q7TQ90 Adh4 31 31 0 49.5...”
- Inflammation and apoptosis accelerate progression to irreversible atrophy in denervated intrinsic muscles of the hand compared with biceps: proteomic analysis of a rat model of obstetric brachial plexus palsy.
Yu, Neural regeneration research 2020 - “...12 P12785 * , A0A0G2K5G8 * , Q63151 * , P33124, P17764, Q9WVK7, Q9WVK3, P08503, P70584, P14604, Q5M9H2, Q63704 0.002 Pathways at 5 weeks Glycolysis/gluconeogenesis 29 G3V9W6 * , P25113 * , D3ZZN3, P07323, P30835, A0A0G2JZH8, Q6P9U7, E9PTN6, D4A5G8, Q9Z1N1, B1WBN9, P49432, E9PTV9, Q6P6R2, P08461, P27881,...”
- “...A0A0G2JZH8, A0A0G2K1W9, O88989 < 0.001 Fatty acid metabolism 18 O35547 * , Q63151 * , P70584, Q9WVK3, P33124, G3V9U2, P14604, P17764, P15651, Q64428, Q5M9H2, Q9WVK7, Q60587, P18163, P18886, P08503, P07896, G3V7N5 < 0.001 Calcium signaling 16 P11275, P20651, A0A0G2K9C8, P13286, Q64578, A0A0G2JSR0, F1LLZ7, Q304F3, G3V731, A0A0G2K5J1,...”
- Functional proteomic analysis of corticosteroid pharmacodynamics in rat liver: Relationship to hepatic stress, signaling, energy regulation, and drug metabolism.
Ayyar, Journal of proteomics 2017 - “...beta oxidation - catalyses the carboxylation reaction of propionyl CoA to form (S)-methylmalonyl CoA UP P70584 Acadsb Short/branched chain acyl-CoA dehydrogenase, mitochondrial Fatty acid beta oxidation - greatest activity toward short branched chain acyl-CoA derivatives UP/DOWN P15651 Acads Short-chain specific acyl-CoA dehydrogenase (SCAD) Fatty acid beta...”
- Differential permeabilization effects of Ca2+ and valinomycin on the inner and outer mitochondrial membranes as revealed by proteomics analysis of proteins released from mitochondria
Yamada, Molecular & cellular proteomics : MCP 2009 - “...Mt, Cy Cy, N IMS IM M M M Mt P04182 P00507 Q64602 P15650 P70584 P32551 Q63276 P12007 P08503 P17764 O09171 P15651 49 48 48 48 48 48 47 47 47 45 45 45 M M Mt M M...”
- A single acyl-CoA dehydrogenase is required for catabolism of isoleucine, valine and short-chain fatty acids in Aspergillus nidulans.
Maggio-Hall, Fungal genetics and biology : FG & B 2008
Q9DBL1 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial from Mus musculus
NP_080102 short/branched chain specific acyl-CoA dehydrogenase, mitochondrial from Mus musculus
38% identity, 86% coverage
- Proteomic Assessment of C57BL/6 Hippocampi after Non-Selective Pharmacological Inhibition of Nitric Oxide Synthase Activity: Implications of Seizure-like Neuronal Hyperexcitability Followed by Tauopathy
Hendrickx, Biomedicines 2022 - “...0.0266 O35737 Hnrnph1 Heterogeneous nuclear ribonucleoprotein H 0.833 0.0266 P16858 Gapdh Glyceraldehyde-3-phosphate dehydrogenase 0.961 0.0333 Q9DBL1 Acadsb Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial 0.916 0.0333 P60710 Actb Actin, cytoplasmic 1 0.907 0.0394 biomedicines-10-01772-t003_Table 3 Table 3 Top 10 most significant MGI Mammalian Phenotype terms for the...”
- Effects of Hyperoxia and Hyperoxic Oscillations on the Proteome of Murine Lung Microvascular Endothelium
Tiboldi, Antioxidants (Basel, Switzerland) 2022 - “...1 Q3U1W3 Adam9 0.00134 1 . 308 91,848 MOUSE Disintegrin and metalloproteinase domain-containing protein 9 Q9DBL1 Acadsb 0.01594 1 . 349 47,874.5 MOUSE Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial Q03145 Epha2 0.01586 1 . 402 108,853.2 MOUSE Ephrin type-A receptor 2 O70439 Stx7 0.02471 1 ....”
- ISG15 Is a Novel Regulator of Lipid Metabolism during Vaccinia Virus Infection.
Albert, Microbiology spectrum 2022 - “...5.03 P52825 Cpt2 Carnitine O -palmitoyltransferase 2, mitochondrial 4.69 Q60759 Gcdh Glutaryl-CoA dehydrogenase, mitochondrial 4.47 Q9DBL1 Acadsb Short/branched-chain-specific acyl-CoA dehydrogenase, mitochondrial 4.41 Q9Z2Z6 Slc25a20 Mitochondrial carnitine/acylcarnitine carrier protein 4.14 P41216 Acsl1 Long-chain fatty acid-CoA ligase 1 3.38 P32020 Scp2 Sterol carrier protein 2 3.24 Q9D1I5 Mcee...”
- “...Q9CQ62 Decr1 2,4-Dienoyl-CoA reductase ([3E]-enoyl-CoA-producing), mitochondrial 4.23 P50544 Acadvl Very long-chain-specific acyl-CoA dehydrogenase, mitochondrial 3.55 Q9DBL1 Acadsb Short/branched-chain-specific acyl-CoA dehydrogenase, mitochondrial 3.04 Q60759 Gcdh Glutaryl-CoA dehydrogenase, mitochondrial 3.02 Q8K370 Acad10 Acyl-CoA dehydrogenase family member 10 2.12 Q8CAY6 Acat2 Acetyl-CoA acetyltransferase, cytosolic 2.61 P97742 Cpt1a Carnitine O...”
- Effects of microgravity exposure and fructo-oligosaccharide ingestion on the proteome of soleus and extensor digitorum longus muscles in developing mice.
Ohira, NPJ microgravity 2021 - “...=1.6E1 Acadm (P45952) * FC=0.53, P =1.5E3 * FC=0.61, P =2.8E4 FC=0.94, P =2.3E1 Acadsb (Q9DBL1) * FC=0.70, P =5.9E3 FC=0.83, P =6.4E2 FC=0.90, P =2.8E1 Acadvl (P50544) * FC=0.69, P =3.4E4 * FC=0.78, P =4.1E3 FC=0.93, P =1.7E1 Acox1 (Q9R0H0) * FC=0.15, P =8.0E4 *...”
- Proteomic profiling of liver tissue from the mdx-4cv mouse model of Duchenne muscular dystrophy
Murphy, Clinical proteomics 2018 - “...medium, long and very long chain specific acyl-CoA dehydrogenases (P51174, Q8K370, Q8JZN5, P45952, Q07417, P50544, Q9DBL1, Q80XL6) and 3-hydroxyacyl-CoA dehydrogenase (O08756), and (5) enzymes of ketone body metabolism, including the cytoplasmic HMGCS1 isoform (Q8JZK9) and mitochondrial HMGCS2 isoform (P54869) of hydroxyl-methylglutaryl-CoA synthase. Proteomic profiling of liver...”
- Subproteomic profiling of sarcolemma from dystrophic mdx-4cv skeletal muscle.
Murphy, Data in brief 2018 - “...1.5 6.12E-03 1.9 P47955 Rplp1 60S acidic ribosomal protein P1 1 1 3.1 1.05E-04 1.8 Q9DBL1 Acadsb Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial 1 1 93.0 6.83E-03 1.8 Q9CQY5 Magt1 Magnesium transporter protein 1 1 1 66.1 9.76E-03 1.8 Q9D6Y9 Gbe1 1,4-alpha-glucan-branching enzyme 1 1 1.7...”
- A new non-canonical pathway of Gα(q) protein regulating mitochondrial dynamics and bioenergetics
Benincá, Cellular signalling 2014 - “...6.73 117.94 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial OS=Mus musculus GN=Idh3a PE=1 SV=1 - [IDH3A_MOUSE] Q9DBL1 49.77 34 21 432 47.8 7.87 115.01 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial OS=Mus musculus GN=Acadsb PE=1 SV=1 - [ACDSB_MOUSE] Q07417 59.22 34 24 412 44.9 8.79 106.53 Short-chain specific...”
- Postconditioning leads to an increase in protein S-nitrosylation
Tong, American journal of physiology. Heart and circulatory physiology 2014 - “...Succinyl-CoA ligase subunit P03899 Q91ZA3 Q9DBL1 Q9CZB0 Q8K2B3 Q8BWF0 Q9WUM5 Q9Z2I9 Voltage-dependent anion-selective channel-1 Voltage-dependent...”
- More
- LncMyoD Promotes Skeletal Myogenesis and Regulates Skeletal Muscle Fiber-Type Composition by Sponging miR-370-3p.
Zhang, Genes 2021 - GeneRIF: LncMyoD Promotes Skeletal Myogenesis and Regulates Skeletal Muscle Fiber-Type Composition by Sponging miR-370-3p.
- Molecular processes during fat cell development revealed by gene expression profiling and functional annotation
Hackl, Genome biology 2005 - “...(Acadm) NP_031408 153 6/9 Isovaleryl-CoA dehydrogenase (Acad) Mm.6635 510 6 Acyl-CoA dehydrogenase, short/branched chain (Acadsb) NP_080102 220 9 Triglyceride metabolism Adipose triglyceride lipase (Pnpla2/Atgl) NP_080078 157 6 CoA biosynthesis Pantothenate kinase 3 NP_666074 140 6 Anaplerotic processes Pyruvate carboxylase NP_032823 149 6 Branched chain amino acid...”
GAH_01601 acyl-CoA dehydrogenase family protein from Geoglobus ahangari
42% identity, 98% coverage
- The complete genome sequence and emendation of the hyperthermophilic, obligate iron-reducing archaeon "Geoglobus ahangari" strain 234(T)
Manzella, Standards in genomic sciences 2015 - “...in G. ahangari are putatively encoded by 11 genes (GAH_00179, GAH_00421, GAH_00484, GAH_00591, GAH_01331, GAH_01442, GAH_01601, GAH_01810, and GAH_02050). A water molecule is then added to trans-2-enoyl-CoA to form (3S)-3-hydroxyacyl-CoA in a reaction catalyzed by an enoyl-CoA hydratase, which in G. ahangari could be encoded by...”
3pfdC / G7CNE7 Crystal structure of an acyl-coa dehydrogenase from mycobacterium thermoresistibile bound to reduced flavin adenine dinucleotide solved by combined iodide ion sad mr (see paper)
42% identity, 96% coverage
- Ligand: dihydroflavine-adenine dinucleotide (3pfdC)
Elgi_47060 acyl-CoA dehydrogenase family protein from Paenibacillus elgii
40% identity, 97% coverage
- Data on annotation and analysis of genome sequence of Paenibacillus elgii YSY-1.2, a promising chitinase-producing, plant-growth-promoting, and biocontrol agent
Tran, Data in brief 2024 - “...Nitrate/nitrite transporter Elgi_17100 Nitrate transporter NarK Elgi_46520 ACC biosynthesis Acyl-CoA dehydrogenase FadE Elgi_23140 Acyl-CoA dehydrogenase Elgi_47060, Elgi_54500, Elgi_67150 Acyl-CoA dehydrogenase family protein Elgi_51250 Acyl-CoA dehydrogenase AcdA Elgi_54520 Iron uptake Iron ABC transporter permease Elgi_01060, Elgi_13560, Elgi_13570, Elgi_14480, Elgi_14540, Elgi_15350, Elgi_16730, Elgi_25990, Elgi_26000, Elgi_27700, Elgi_29320, Elgi_29330, Elgi_33950,...”
PA14_43420 putative acyl-CoA dehydrogenase from Pseudomonas aeruginosa UCBPP-PA14
41% identity, 98% coverage
PA1631 probable acyl-CoA dehydrogenase from Pseudomonas aeruginosa PAO1
A4W92_RS03220 acyl-CoA dehydrogenase family protein from Pseudomonas aeruginosa
41% identity, 98% coverage
- An atlas of the binding specificities of transcription factors in Pseudomonas aeruginosa directs prediction of novel regulators in virulence
Wang, eLife 2021 - “...for the predicted binding of PhoB in the promoters of PA0136, PA2803, PA2548, PA0842, PA3940, PA1631, phoA , PA0730, PA2428, PA3250, ctpL , PA5473, aer , yrfI , aspA , PA1736, panB , PA1769, and PA3258. By contrast, the promoter fragment of triA is used as...”
- Static Growth Promotes PrrF and 2-Alkyl-4(1H)-Quinolone Regulation of Type VI Secretion Protein Expression in Pseudomonas aeruginosa
Brewer, Journal of bacteriology 2020 (secret) - Dissection of the cis-2-decenoic acid signaling network in Pseudomonas aeruginosa using microarray technique
Rahmani-Badi, Frontiers in microbiology 2015 - “...uppS, mdcA, atuC,PA0098, PA0182,PA0286, PA0493, PA0506-PA0508, PA0745-PA0746, PA0879, PA1020-PA1022, PA1187, PA1240, PA1470, PA1535, PA1576, PA1628-PA1629, PA1631, PA1827, PA1869, PA2550, PA2552, PA2815, PA2841, PA2887-PA2891, PA2893, PA3286, PA3426, PA3589, PA3591, PA3593, PA3924,PA4089, PA4330, PA4912, PA4979-PA4980, PA4995, PA5020, PA5524 Protein and Amino acid metabolism thrS, folC, glnA, gmk, tgt,...”
- Cloning and genetic characterization of dca genes required for beta-oxidation of straight-chain dicarboxylic acids in Acinetobacter sp. strain ADP1
Parke, Applied and environmental microbiology 2001 - “...dcaE (PA1629), dcaH (PA1628), dcaR (PA1630), and dcaA (PA1631). In Acinetobacter, dcaR is linked to dcaF and has been identified tentatively as one of...”
- “...in the aligned portion of the proteins. Only DcaA homolog PA1631 is very similar to its ADP1 homolog. In addition, the DcaA homolog PA3593 is 191 amino acids...”
- Insights into the Synergistic Antibacterial Activity of Silver Nitrate with Potassium Tellurite against Pseudomonas aeruginosa
Pormohammad, Microbiology spectrum 2023 - “...48 ). On the other hand, the parallel upregulation of acyl coenzyme A (acyl-CoA) dehydrogenase (A4W92_RS03220; see Table S3) (which catalyzes the first step in the -oxidation of fatty acids) might be an alternative pathway in the generation of acetyl-CoA to allow the operation of the...”
A5U7U8 Acyl-CoA dehydrogenase FadE25 from Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
Rv3274c PROBABLE ACYL-CoA DEHYDROGENASE FADE25 from Mycobacterium tuberculosis H37Rv
MRA_3315 acyl-CoA dehydrogenase FadE25 from Mycobacterium tuberculosis H37Ra
42% identity, 96% coverage
- The Inhibitory Effect of GlmU Acetyltransferase Inhibitor TPSA on Mycobacterium tuberculosis May Be Affected Due to Its Methylation by Methyltransferase Rv0560c
Chen, Frontiers in cellular and infection microbiology 2019 - “...3-oxoacyl-(Acyl-carrier-protein) synthase 1 43.29 5.11 0.015 10 486 442 2.02 206 MRA_3315 ( fadE25 ) A5U7U8 Acyl-CoA dehydrogenase 41.70 5.21 0.019 16 132 35 2.70 203 MRA_0251 ( fabG-1 ) A5TYW8 3-ketoacyl-(Acyl-carrier-protein) reductase 46.83 6.04 <0.0001 13 432 389 4.93 197 MRA_0251 ( fabG-1 ) A5TYW8...”
- Ancient Bacterial Class Alphaproteobacteria Cytochrome P450 Monooxygenases Can Be Found in Other Bacterial Species
Nzuza, International journal of molecular sciences 2021 - “...pzu:PHZ_c0890 33 51 Acyl-CoA dehydrogenase fadE24 Rv3139 Acyl-CoA dehydrogenase pzu:PHZ_c2365 32 48 Acyl-CoA dehydrogenase fadE25 Rv3274c Acyl-CoA dehydrogenase FADE25 pzu:PHZ_c1680 40 60 Acyl-CoA dehydrogenase fadE26 Rv3504 Probable acyl-CoA dehydrogenase pzu:PHZ_c2336 33 50 Acyl-CoA dehydrogenase fadE27 Rv3505 Probable acyl-CoA dehydrogenase pzu:PHZ_c2406 28 45 Isovaleryl CoA dehydrogenase fadE28...”
- Rv0180c contributes to Mycobacterium tuberculosis cell shape and to infectivity in mice and macrophages
Payros, PLoS pathogens 2021 - “...the virulence of M . tuberculosis . This includes: three genes rv0244c ( fadE5 ), rv3274c ( fadE25 ) and rv3544c ( fadE28 ) encoding acyl-CoA dehydrogenases required for growth on cholesterol and predicted to be involved in cholesterol side-chain -oxidation and degradation [ 20 ,...”
- One-Year Old Dormant, "Non-culturable" Mycobacterium tuberculosis Preserves Significantly Diverse Protein Profile
Trutneva, Frontiers in cellular and infection microbiology 2020 - “...(alpha chain) RpoA Rv1308 Probable ATP synthase alpha chain AtpA Rv3846 Superoxide dismutase [FE] SodA Rv3274c Probable acyl-CoA dehydrogenase FadE25 Rv1630 30S ribosomal protein S1 RpsA Rv2780 Secreted L-alanine dehydrogenase Ald (40 kDa antigen) (TB43) Rv3914 Thioredoxin TrxC (TRX) (MPT46) Rv0667 DNA-directed RNA polymerase (beta chain)...”
- Comprehensive Comparative Analysis of Cholesterol Catabolic Genes/Proteins in Mycobacterial Species
van, International journal of molecular sciences 2019 - “...Rv3061c e acyl-CoA dehydrogenase fadE24 Rv3139 e acyl-CoA dehydrogenase fadE23 Rv3140 e acyl-CoA dehydrogenase fadE25 Rv3274c c acyl-CoA dehydrogenase FADE25 choD Rv3409c d cholesterol oxidase gcp Rv3419c c putative DNA-binding/iron metalloprotein/AP endonuclease Rv3421c c HP Rv3492c c CHP MCE associated protein Rv3493c c CHP MCE associated...”
- A chemical proteomics approach to profiling the ATP-binding proteome of Mycobacterium tuberculosis
Wolfe, Molecular & cellular proteomics : MCP 2013 - “...0.86 Integration host factor, MihF Rv1388 21 kDa (0.0001) 41.33 34.67 0.84 acyl-CoA dehydrogenase, FadE25 Rv3274c 42 kDa (0.3500) 2.00 1.67 0.83 DNA polymerase III chain, DnaN Rv0002 42 kDa (0.3500) 2.00 1.67 Pyridoxamine 5-phosphate oxidase, PdxH Rv2607 25 kDa (0.1100) 5.67 4.67 0.82 10-kDa chaperonin,...”
- Updating and curating metabolic pathways of TB
Slayden, Tuberculosis (Edinburgh, Scotland) 2013 - “..., 55 , 99 fadE18 Rv1933c acyl-CoA dehydrogenase E 54 , 55 , 99 fadE25 Rv3274c acyl-CoA dehydrogenase D fadE26 Rv3504 acyl-CoA dehydrogenase E fadE27 Rv3505 acyl-CoA dehydrogenase E fadE28 Rv3544c acyl-CoA dehydrogenase B, C, D, E, F 54 , 55 , 99 fadE29 Rv3543c acyl-CoA...”
- The Inhibitory Effect of GlmU Acetyltransferase Inhibitor TPSA on Mycobacterium tuberculosis May Be Affected Due to Its Methylation by Methyltransferase Rv0560c
Chen, Frontiers in cellular and infection microbiology 2019 - “...( kasA ) A5U4S7 3-oxoacyl-(Acyl-carrier-protein) synthase 1 43.29 5.11 0.015 10 486 442 2.02 206 MRA_3315 ( fadE25 ) A5U7U8 Acyl-CoA dehydrogenase 41.70 5.21 0.019 16 132 35 2.70 203 MRA_0251 ( fabG-1 ) A5TYW8 3-ketoacyl-(Acyl-carrier-protein) reductase 46.83 6.04 <0.0001 13 432 389 4.93 197 MRA_0251...”
Shewana3_2769 Branched-chain acyl-CoA dehydrogenase (EC 1.3.99.12) from Shewanella sp. ANA-3
41% identity, 98% coverage
- mutant phenotype: Specifically important for: L-Isoleucine. specificity for isoleucine indicates that 2-methylbutanoyl-CoA is a substrate
M892_24055 acyl-CoA dehydrogenase family protein from Vibrio campbellii ATCC BAA-1116
41% identity, 98% coverage
MAP2312c FadE19 from Mycobacterium avium subsp. paratuberculosis str. k10
43% identity, 96% coverage
- Recent Trends in System-Scale Integrative Approaches for Discovering Protective Antigens Against Mycobacterial Pathogens
Rana, Frontiers in genetics 2018 - “...design novel and more efficient vaccines against TB ( Monterrubio-Lpez, 2015 ). Eight proteins (MAP2698c, MAP2312c, MAP3651c, MAP2872c, MAP3523c, MAP0187c and the hypothetical proteins MAP3567 and MAP1168c) were also identified with highly immunogenic epitopes in the MAP as potential vaccine candidates for studying antibody and cell-mediated...”
- In silico identification of epitopes in Mycobacterium avium subsp. paratuberculosis proteins that were upregulated under stress conditions
Gurung, Clinical and vaccine immunology : CVI 2012 - “...epitopes, eight proteins (MAP2698c [encoded by desA2], MAP2312c [encoded by fadE19], MAP3651c [encoded by fadE3_2], MAP2872c [encoded by fabG5_2], MAP3523c...”
- “...Table 3. Five proteins (MAP2698c, MAP3567, MAP3651c, MAP3523c, and MAP2312c) were found to carry the largest numbers of MHC class I T cell epitopes of...”
TTC0779 No description from Thermus thermophilus HB27
40% identity, 98% coverage
- Transposon mutagenesis of the extremely thermophilic bacterium Thermus thermophilus HB27
Carr, Extremophiles : life under extreme conditions 2015 - “...UDP-N-acetylglucosamine 2-epimerase 1 JC1054 TTC0600 livF ; branched-chain amino acid transport ATP-binding protein 1 JC949 TTC0779 acyl-CoA dehydrogenase 1 JC1093 TTC0980 mannose-6-phosphate isomerase 2 e.g. JC915 TTC1005 serine protease-like protein 1 JC848 intergenic TTC1044-1045 between ccdA , cytochrome C-type biogenesis protein and cytochrome c 1 JC1099...”
1ukwA / Q72JJ3 Crystal structure of medium-chain acyl-coa dehydrogenase from thermus thermophilus hb8
40% identity, 98% coverage
- Ligand: flavin-adenine dinucleotide (1ukwA)
Q9VVU1 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial from Drosophila melanogaster
CG3902 uncharacterized protein from Drosophila melanogaster
39% identity, 90% coverage
- The Stearoyl-CoA Desaturase-1 (Desat1) in Drosophila cooperated with Myc to Induce Autophagy and Growth, a Potential New Link to Tumor Survival
Paiardi, Genes 2017 - “...+1.71 1.48 10 6 16 MECR Probable trans-2-enoyl-CoA reductase, mitochondrial +1.3 1.61 10 22 3 Q9VVU1 Acyl-CoA dehydrogenase activity CG3902 +1.4 1.21 10 19 14 Q9VDT1 Arc42 +1.44 1.24 10 36 7 Q9VCC6 fatty acyl-CoA synthase activity CG6178 +1.71 3.71 10 28 7 Q9W5W8 isomerase activity...”
- The protein-protein interaction network of eyestalk, Y-organ and hepatopancreas in Chinese mitten crab Eriocheir sinensis
Hao, BMC systems biology 2014 - “...16 proteins (Q8IQV6, Q7JXG9, Q8IR25, D3ZE26, Q9V3S7, Q9V3A8, Q7KMH9, Q7JPS2, Q9VVK8, Q9W1A7, Q7KN04, Q8SZY2, Q9VUP0, Q9VVU1, Q9VLK8, A1ZA45) were annotated as Hippo signaling cascade and 12 other proteins (Q8IQV6, Q7JXG9, Q8IR25, Q9V3S7, Q9V3A8, Q7KMH9, Q7JPS2, Q9VVK8, E1JII4, Q8SZY2, Q9VVU1, Q9VLK8) functioned as regulators of Hippo signaling...”
- High sugar diet-induced fatty acid oxidation potentiates cytokine-dependent cardiac ECM remodeling
Gera, The Journal of cell biology 2024 - “...PCs analyzed for each genotype. (D and E) Increase in the reporter YFP expression for CG3902 in the PCs of HSD-fed flies (E) as compared to those fed on ND (D). Phalloidin (red) marks the cardiac tube and the alary muscles. (F) Quantification of the mean...”
- “...and P ). Similar enrichment in the levels of reporter YFP expression for acyl-CoA dehydrogenase (CG3902) was also observed in the PCs of HSD-fed flies ( Fig. S3, DF ). Furthermore, compared with that observed for ND-fed flies, elevated levels of expression of the critical genes...”
- scRNA-seq Reveals Novel Genetic Pathways and Sex Chromosome Regulation in Tribolium Spermatogenesis
Robben, Genome biology and evolution 2024 - “...0.003 Fly Glut3 Elongating spermatid FBgn0015230 Fly tj Hub Cyst Cell FBgn0000964 TcasGA2-TC033194 0 Fly CG3902 Hub Cyst Cell FBgn0036824 TcasGA2-TC005596 0.007 Fly piwi Hub Cyst Cell FBgn0004872 TcasGA2-TC008711 0.09 Fly Amph Hub Cyst Cell FBgn0027356 TcasGA2-TC032117 0.24 Fly eya Cyst cell FBgn0000320 TcasGA2-TC008985 0.09 Fly...”
- Icaritin greatly attenuates β-amyloid-induced toxicity in vivo
Li, CNS neuroscience & therapeutics 2024 - “...shown in Figure 6N . The qRTPCR results verified that the expression of Egm, Echs1, CG3902, and CG8778 is consistent with that of the transcriptome data (Figure 6O ). The expression of CG9547 and Yip2 was unchanged under A arc expression, while Icaritin activated the expression...”
- Spenito-dependent metabolic sexual dimorphism intrinsic to fat storage cells
Diaz, Genetics 2023 - “...TGGACAAGATTCACG CCATTC 3 and 5 CGACCACCTGTAGTAGCCATC 3; CG3902, 5 CTCACCGACGATGAGAAAATGA 3 and 5 CACGGAGGGATCGA ATTTGTG 3; baldspot, 5 GTGGTCAGCACTTTATGCAAAAT 3...”
- “...(Thimgan et al. 2015), the short-chain 2-methylacyl-CoA dehydrogenase CG3902, the known or pre dicted fatty acid binding proteins fabp and CG4586, and the...”
- Emergent dynamics of adult stem cell lineages from single nucleus and single cell RNA-Seq of <i>Drosophila</i> testes
Raz, eLife 2023 - “...the same cell type in the UMAP and its corresponding IF image. ( E ) CG3902 mRNA expression projected on the UMAP. ( F ) Apical tip of testis expressing GFP protein trap of CG3902. ( G ) Akr1B mRNA expression projected on the UMAP. (...”
- “...cells (ScCC) ( Li et al., 2003 ; Zoller and Schulz, 2012 ). Complementing this, CG3902 mRNA was also detected in the same clusters as tj , and a CG3902 protein trap line revealed cytoplasmic protein accumulation up to early ScCC and no detectable protein thereafter...”
- Early-adult methionine restriction reduces methionine sulfoxide and extends lifespan in Drosophila
Kosakamoto, Nature communications 2023 - “...Glutathione S transferase E7 ( GstE7 ), CCHamide-2 ( CCHa2 ), and an unknown gene CG3902 (Fig. 4e, f ). CCHa2 is an appetite-regulating peptide that is known to promote systemic insulin signalling 41 . Thus, decreased expression of CCHa2 may lead to a pro-longevity state...”
- Chromatin and gene expression changes during female Drosophila germline stem cell development illuminate the biology of highly potent stem cells
Pang, eLife 2023 - “...expression shows other indications of increased lipid metabolism (see Figure 5B , metabolism of lipids). CG3902, encoding an Acyl-CoA dehydrogenase the first step in mitochondrial fatty acid beta-oxidation, is upregulated more than 400-fold. RNA levels increase for both Lpr1 (12-fold) and Lpr2 (87-fold). Hnf4 , encoding...”
- The MicroRNA miR-277 Controls Physiology and Pathology of the Adult Drosophila Midgut by Regulating the Expression of Fatty Acid β-Oxidation-Related Genes in Intestinal Stem Cells
Zipper, Metabolites 2022 - “...shows that FAO metabolic genes CG31075, CG4860, CG5599, CG9547, and whd diminish, while yip2 and CG3902 progressively increase ( Figure 3 b). Mtpalpha diminishes during the differentiation to then increase again in the terminally differentiated pEC ( Figure 3 b). In the reconstructed lineage towards anterior...”
- “...also show similar patterns to the pEC, with the exception of CG5599 which increases progressively, CG3902 which initially increases in the process of differentiation to then diminish in terminally differentiated mEC, and yip2 which increases initially and then diminishes. Although few FAO genes seem to be...”
- More
TO73_1043 acyl-CoA dehydrogenase family protein from Thermus aquaticus Y51MC23
40% identity, 98% coverage
AzCIB_2912 acyl-CoA dehydrogenase family protein from Azoarcus sp. CIB
43% identity, 95% coverage
- Genetic characterization of the cyclohexane carboxylate degradation pathway in the denitrifying bacterium Aromatoleum sp. CIB
Sanz, Environmental microbiology 2022 - “...also present in the CIB genome. We have observed an induction of the aabC paralogue (AzCIB_2912) when Aromatoleum sp. CIBAzCIB_1938 was grown in CHC or benzoate (Figure S5 C), suggesting that cluster AzCIB_29122917, which is not significantly expressed in the wildtype strain growing with benzoate or...”
- “...standard deviations. Click here for additional data file. FIGURE S5 Expression of aab genes and AzCIB_2912 in Aromatoleum sp. CIB strains. Total RNA was isolated from Aromatoleum sp. CIB cells grown anaerobically in MC medium containing 3mM benzoate (Bz), 3mM CHC, or 3mM pimelate (Pim) as...”
TTHA1144 acetyl-Coenzyme A dehydrogenase, medium chain from Thermus thermophilus HB8
40% identity, 92% coverage
- Identification and characterization of preferred DNA-binding sites for the Thermus thermophilus transcriptional regulator FadR
Lee, PloS one 2017 - “...0.0249 CTGTACTCGGTATAA +23 ~ TTHA1634 1089565 1089579 8.10e-08 0.0249 TTTGACCGAGTCTAA 52 Y TTHA1143 +42 Y TTHA1144 103944 103958 6.68e-07 0.135 TTGGACCTGGTAAAA 8 Y TTHA0103 724515 724529 6.99e-07 0.135 CTGGACTTGGTCTAA +909 N TTHA0758 ( P -value) Defined as the probability of a random sequence of the same...”
- “...receiver domain-containing protein 121.8/62.9 1.9 0.228 3 TTHA1141 cation-transporting ATPase 2421.4/854.7 2.8 5.46e-2 Y 1 TTHA1144 acetyl-coenzyme A dehydrogenase medium subunit 6247.9/1088.1 5.7 1.26e-3 2 TTHA1145 electron transfer flavoprotein subunit beta 6786.9/1190.5 5.7 2.26e-3 3 TTHA1146 electron transfer flavoprotein subunit alpha 4030.9/866.5 4.7 1.79e-3 Y 1...”
SO1679 2-methylbutanoyl-CoA dehydrogenase (EC 1.3.8.5) from Shewanella oneidensis MR-1
SO1679, SO_1679 methylbutyrl-CoA oxidoreductase from Shewanella oneidensis MR-1
41% identity, 98% coverage
- mutant phenotype: # Specifically important in carbon source L-Isoleucine; nitrogen source L-Isoleucine (EC 1.3.8.5). Similar to ACAD8_HUMAN (Isobutyryl-CoA dehydrogenase, mitochondrial).
- Evidence-based annotation of gene function in Shewanella oneidensis MR-1 using genome-wide fitness profiling across 121 conditions
Deutschbauer, PLoS genetics 2011 - “...oxidoreductase New SO_1670 200835 Fumarylacetoacetate hydrolase Confirmed Complementation SO_1677 200842 Acetyl-CoA/2-methyl-acetyl-CoA acetyltranferase Expanded Multiple mutants SO_1679 200844 Methylbutyrl-CoA oxidoreductase Confirmed Multiple mutants SO_1683 200848 Putative 2-methyl-3-hydroxybutyryl-CoA dehydrogenase New SO_1854 201016 Outer membrane protein required for motility and nitrate resistance New Multiple mutants SO_1913 201074 Chaperone for...”
- In vivo identification of the outer membrane protein OmcA-MtrC interaction network in Shewanella oneidensis MR-1 cells using novel hydrophobic chemical cross-linkers
Zhang, Journal of proteome research 2008 - “...SO0229 SO0217 SO4749 SO1142 SO4747 SO2638 SO0314 SO3032 SO1679 SOA0112 SO1521 SO3532 SO0021 SO0256 SO4030 SO1295 SO3440 SO1779 SO3542 C denotes cytoplasmic, and...”
- Empirical evaluation of a new method for calculating signal-to-noise ratio for microarray data analysis
He, Applied and environmental microbiology 2008 - “...prepared as previously described (12). Briefly, four genes (SO1679, SO1744, SO2680, and SO0848) were selected from the Shewanella oneidensis MR-1 genome. For...”
- Use of microarrays with different probe sizes for monitoring gene expression
He, Applied and environmental microbiology 2005 - “...targets or synthesized oligonucleotide targets of four loci (SO1679, SO1744, SO2680, and SO0848) were used for hybridization. Five picograms of PCR target per...”
- “...SO0017 SO1383 SO2743 SO4180 SO2320 SO3051 SO2697 SO4661 SO1679 SO2389 SO2953 SO2113 SO2654 SO1157 SO2930 SO1277 SO2886 b 70-mer gene arrays were used, the...”
- Empirical establishment of oligonucleotide probe design criteria
He, Applied and environmental microbiology 2005 - “...the software, PRIMEGENS (33) based on four genes (SO1679, SO1744, SO2680, and SO0848) from the Shewanella oneidensis MR-1 genome. The mismatch (MM) probes were...”
- “...probe signal intensity) was observed for target gene SO1679 at a probe-target identity of 90%, whereas at the same identity relatively strong signals...”
Q95U46 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial from Drosophila melanogaster
39% identity, 90% coverage
DDB_G0288647 acyl-CoA dehydrogenase from Dictyostelium discoideum AX4
40% identity, 90% coverage
FGSG_09661 hypothetical protein from Fusarium graminearum PH-1
41% identity, 84% coverage
Smlt0265 putative acyl CoA dehydrogenase from Stenotrophomonas maltophilia K279a
44% identity, 97% coverage
dcaA / AAL09094.1 DcaA from Acinetobacter baylyi (see 11 papers)
ACIAD1693 acyl-CoA dehydrogenase from Acinetobacter sp. ADP1
39% identity, 96% coverage
SACE_4589 acyl-CoA dehydrogenase from Saccharopolyspora erythraea NRRL 2338
43% identity, 97% coverage
AzCIB_1942 acyl-CoA dehydrogenase family protein from Azoarcus sp. CIB
42% identity, 97% coverage
MSMEG_1821 acyl-CoA dehydrogenase from Mycobacterium smegmatis str. MC2 155
41% identity, 96% coverage
- Unveiling the Biosynthetic Pathway for Short Mycolic Acids in Nontuberculous Mycobacteria: Mycobacterium smegmatis MSMEG_4301 and Its Ortholog Mycobacterium abscessus MAB_1915 Are Essential for the Synthesis of α'-Mycolic Acids
Di, Microbiology spectrum 2022 - “...UNR21 and impact on the corresponding open reading frame (ORF) Gene Function Mutation Protein change MSMEG_1821 Acyl-CoA dehydrogenase g452a R151K MSMEG_1904 Acyl-CoA dehydrogenase g768a K256K MSMEG_2029 3-Ketoacyl-ACP/CoA reductase Insertion c31 Frameshift at AA11 MSMEG_2228 Short-chain dehydrogenase/reductase family c169t P57S MSMEG_3392 Acyl-CoA dehydrogenase domain protein Insertion c199,...”
- “...MSMEG_4301 and other candidate genes in mycobacterial species Gene Function Orthologs in other mycobacteria a MSMEG_1821 Acyl-CoA dehydrogenase M. marinum , M. fortuitum , M. ulcerans , M. avium , M. kansasii MSMEG_1904 Acyl-CoA dehydrogenase M. goodii , M. fortuitum , Mycobacterium sp. strain VKM, Mycobacterium...”
- Protein Composition of Mycobacterium smegmatis Differs Significantly Between Active Cells and Dormant Cells With Ovoid Morphology
Trutneva, Frontiers in microbiology 2018 - “...enzymes found in active cells, there are additional unique enzymes in the dormant cell proteome: MSMEG_1821, MSMEG_1813, MSMEG_6008, MSMEG_6391, MSMEG_2938, MSMEG_5184, and MSMEG_6511). Similarly, enzymes with proteolytic activity were found in both types of cells. However, proteolytic enzymes are more diverse and more represented in the...”
- Gene Expression, Bacteria Viability and Survivability Following Spray Drying of Mycobacterium smegmatis
Lauten, Materials (Basel, Switzerland) 2010 - “...a p-value < 0.01 level of significance. All but two of these genes, acyl-CoA dehrydrogenase (MSMEG_1821) and malonyl CoA-acyl carrier protein transacylase (MSMEG_4325), were upregulated in the multiply cycled bacteria. In the stationary phase comparison there were no genes differentially expressed at p-value < 0.05 level...”
- “...0.046 55% MSMEG_1794 dehydrogenase 0.6 9.4 0.020 81% MSMEG_1802 ChaB protein 0.8 9.2 0.033 89% MSMEG_1821 acyl-CoA dehydrogenase -0.6 9.4 0.017 79% MSMEG_1886 Fatty acid desaturase 0.9 9.9 0.012 88% MSMEG_1950 conserved hypothetical protein 1.0 10.2 0.004 98% MSMEG_1951 conserved domain protein 1.7 10.5 0.003 99%...”
CPS_RS02940 acyl-CoA dehydrogenase family protein from Colwellia psychrerythraea 34H
40% identity, 96% coverage
ML0737 putative acyl-CoA dehydrogenase from Mycobacterium leprae TN
41% identity, 96% coverage
- Intrabacterial lipid inclusion-associated proteins: a core machinery conserved from saprophyte Actinobacteria to the human pathogen Mycobacterium tuberculosis
Dargham, FEBS open bio 2023 - “...Nonessential MSMEG_1743 MAB_2148 MMAR_1315 MUL_2565 RjosMsmeg Rv0154c fadE2 AcylCoA dehydrogenase Nonessential MSMEG_0102 MAB_0255 MMAR_0374 MUL_4790 ML0737 RopRjos Rv0895 Triacylglycerol synthase Nonessential MSMEG_6322 MAB_4544c MMAR_5271 MUL_2057 ML1244 RopRjos Rv3391 acrA1 Multifunctional enzyme with acylCoAreductase activity Nonessential MSMEG_1623 MAB_3710 MMAR_1153 MUL_0918 ML0862 RopRjos Rv0400c fadE7 AcylCoA dehydrogenase Nonessential...”
- Lipid Droplets and Mycobacterium leprae Infection
Elamin, Journal of pathogens 2012 - “...fadD26 (ML2358, fatty acid-CoA-ligase), fadD29 (ML0132, probable fatty-acid-CoA synthetase), fadD28 (ML0138, possible fatty-acid-CoA synthase), fadE25 (ML0737, probable acyl-CoA dehydrogenase), and fadE5 (ML2563, acyl-CoA dehydrogenase) [ 91 , 92 ]. Combing observations from leprosy lesions, this gives strong evidence that host lipids provide the main carbon and...”
SCO3051 acyl-CoA dehydrogenase from Streptomyces coelicolor A3(2)
Q7AKM9 Acyl-CoA dehydrogenase from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
42% identity, 97% coverage
- Unlocking a new target for streptomycetes strain improvement
Chen, Synthetic and systems biotechnology 2020 - “...mutants, TAG degradation was triggered by energetic stress. The expression of -oxidation enzymes such as SCO3051 (acyl-CoA dehydrogenase) and SCO5144 (enoyl-CoA hydratase) was elevated, generating a flux of acetyl-CoA toward the production of ACT. Conversely, wild type S. lividans , a weak producer of ACT, accumulated...”
- Comparative proteomic analysis of Streptomyces lividans Wild-Type and ppk mutant strains reveals the importance of storage lipids for antibiotic biosynthesis
Le, Applied and environmental microbiology 2013 - “...strain. (b) Lipid/fatty acid metabolism. An acyl-CoA dehydrogenase (SCO3051) that catalyzes the first step of the beta-oxidation of fatty acids, whose end...”
- “...protein (myoinositol catabolism protein IolB; putative 5-deoxy-glucuronate isomerase) SCO3051 SCO1565 Q7AKM9 Q8CJI8 42/5.3 39/6.2 103 225 26 44 Up Down 4 4...”
- Genome-wide analysis of the role of GlnR in Streptomyces venezuelae provides new insights into global nitrogen regulation in actinomycetes
Pullan, BMC genomics 2011 - “...AC Sven_1677 SCO2026 Glutamate synthase -1.1 GT A AC CTGCAC G AA A T Sven_5967 SCO3051 FadE acetyl CoA dehydrogenase -1.3 G AC AC CCCGAGT T A AC Sven_6632 SCO5685 Putative sugar hydrolase 1.4 GT T A AGTGAAC GT C AC Sven_0035 Secreted protein -1.2 GT...”
- Comparative proteomic analysis of Streptomyces lividans Wild-Type and ppk mutant strains reveals the importance of storage lipids for antibiotic biosynthesis
Le, Applied and environmental microbiology 2013 - “...catabolism protein IolB; putative 5-deoxy-glucuronate isomerase) SCO3051 SCO1565 Q7AKM9 Q8CJI8 42/5.3 39/6.2 103 225 26 44 Up Down 4 4 SCO6976 Q9KZH6 32/5.1 184...”
SLCG_5215 acyl-CoA dehydrogenase family protein from Streptomyces lincolnensis
43% identity, 97% coverage
- PAS domain containing regulator SLCG_7083 involved in morphological development and glucose utilization in Streptomyces lincolnensis
Lin, Microbial cell factories 2023 - “...118.03 -1.51 0.017798 cyclitol dehydrogenase 84/90 Streptomyces griseofuscus , WP_125212155.1 1.1.1.- Lipid transport and metabolism SLCG_5215 213.11 825.51 1.95 0.040887 short-chain acyl-CoA dehydrogenase 96/98 Streptomyces hokutonensis , WP_019065764.1 1.3.99.12 SLCG_5739 241.29 698.13 1.53 0.043582 acetyl-CoA acetyltransferase 98/99 Streptomyces canus , WP_062042393.1 2.3.1.9 SLCG_7149 203.80 547.39 1.43...”
- “...They encode proteins involved in fatty acids oxidative catabolic pathway, including a short-chain acyl-CoA dehydrogenase (SLCG_5215), two acetyl-CoA acetyltransferases (SLCG_5739 and SLCG_7151), an acyl-CoA transferases (SLCG_7149), a long-chain specific acyl-CoA dehydrogenase (SLCG_7150), a fatty acid oxidative multifunctional enzyme (SLCG_7152). In particular, four of them ( SLCG_7149...”
Afu1g14850 acyl-CoA dehydrogenase, putative from Aspergillus fumigatus Af293
40% identity, 85% coverage
4iv6B / A0QTW7 X-ray crystal structure of an isovaleryl-coa dehydrogenase from mycobacterium smegmatis (see paper)
41% identity, 97% coverage
- Ligand: dihydroflavine-adenine dinucleotide (4iv6B)
FOXG_08409 acyl-CoA dehydrogenase from Fusarium oxysporum f. sp. lycopersici 4287
40% identity, 84% coverage
XP_658428 protein scdA from Aspergillus nidulans FGSC A4
39% identity, 85% coverage
CCI6_RS05135 acyl-CoA dehydrogenase family protein from Frankia sp. CcI6
43% identity, 97% coverage
PA0746 probable acyl-CoA dehydrogenase from Pseudomonas aeruginosa PAO1
42% identity, 97% coverage
- The Pseudomonas aeruginosa RpoH (σ32) Regulon and Its Role in Essential Cellular Functions, Starvation Survival, and Antibiotic Tolerance
Williamson, International journal of molecular sciences 2023 - “...operon includes enzymes for fatty acid biosynthesis, including Enoyl-CoA hydratase/isomerase (PA0744 and PA0745), Acyl-CoA dehydrogenase (PA0746), and NAD-dependent aldehyde dehydrogenase (PA0747). The structure and function of PA0745 (DspI) were determined [ 70 ] and shown to be involved in the dehydration reaction cis-2-decenoic acid, a signaling...”
- “...PA0744 Enoyl-CoA hydratase/isomerase 8.3 3.0 10 4 PA0745 dspI Enoyl-CoA hydratase/isomerase 10.7 6.2 10 4 PA0746 Acyl-CoA dehydrogenase 10.5 1.8 10 3 PA0747 NAD-dependent aldehyde dehydrogenase 14.2 6.3 10 4 PA0763 mucA Anti-sigma factor 2.1 2.5 10 3 + PA0764 mucB Negative regulator for alginate biosynthesis...”
- The Small RNAs PA2952.1 and PrrH as Regulators of Virulence, Motility, and Iron Metabolism in Pseudomonas aeruginosa
Coleman, Applied and environmental microbiology 2021 (secret) - Mitochondrial targeting increases specific activity of a heterologous valine assimilation pathway in Saccharomyces cerevisiae
Solomon, Metabolic engineering communications 2016 - “...( Sambrook and Russell, 2001 ) and plasmids were maintained in E. coli XL1B. acd1 (PA0746), bkdA1 (PA2247), bkdA2 (PA2248), bkdB (PA2249), and lpdV (PA2250), encoding the acyl-CoA dehydrogenase and branched chain keto acid dehydrogenase complex, respectively, from Pseudomonas aeruginosa PA01, were PCR amplified from plasmid...”
- The pathogenicity island encoded PvrSR/RcsCB regulatory network controls biofilm formation and dispersal in Pseudomonas aeruginosa PA14
Mikkelsen, Molecular microbiology 2013 - “...Histidine phosphotransfer protein HptC PA0034 * 8.6 Probable two-component response regulator PA0267 6.8 Hypothetical protein PA0746 5.4 Probable acyl-CoA dehydrogenase PA1468 * 9.9 Hypothetical protein PA1571 4.5 Hypothetical protein PA1664 9.4 orfX OrfX PA2075 4.1 Hypothetical protein PA2111 6.5 Hypothetical protein PA2553 6.0 Probable acyl-CoA thiolase...”
- Bacterial cis-2-unsaturated fatty acids found in the cystic fibrosis airway modulate virulence and persistence of Pseudomonas aeruginosa
Twomey, The ISME journal 2012 - “...classa Fold changesb WT+DSF versus WT PA0744 PA0745 PA0746 PA0747 PA0806 PA1325 PA1326 PA1327 PA1467 PA1559 PA1560 PA1797 PA1889 PA2339 PA2966 PA3790 PA4138...”
- Genome-wide identification of Pseudomonas aeruginosa virulence-related genes using a Caenorhabditis elegans infection model
Feinbaum, PLoS pathogens 2012 - “...gene of what is most likely a 5 gene operon: PA0747 a probable aldehyde dehydrogenase, PA0746 a putative acyl-CoA dehydrogenase, PA0745, PA0744 another putative enoyl-CoA hydratase/isomerase, and PA0743 a probable 3-hydroxyisobutyrate dehydrogenase. B) Insertions in PA0745 exhibit a virulence-attenuated phenotype but mutants of PA0746, the only...”
- Pseudomonas aeruginosa twitching motility-mediated chemotaxis towards phospholipids and fatty acids: specificity and metabolic requirements
Miller, Journal of bacteriology 2008 - “...PA0358 PA0482 PA0506 PA0507 PA0508 PA0743 PA0744 PA0745 PA0746 PA0792 PA0795 PA0796 PA0797 PA0887 PA1137 PA1288 PA1736 PA1737 PA2011 PA2012 PA2013 PA2014 PA2015...”
- The Pseudomonas aeruginosa proteome during anaerobic growth
Wu, Journal of bacteriology 2005 - “...PA0100 PA0128 PA0139 PA0195 PA0399 PA0447* PA0534 PA0588 PA0746 PA0853 PA0854 PA0870 PA0871 PA0872 PA0916 PA0997* PA0998* PA0999* PA1002* PA1228 PA1529 PA1574...”
- More
scdA acyl-CoA dehydrogenase, putative (AFU_orthologue; AFUA_1G14850) from Emericella nidulans (see paper)
39% identity, 85% coverage
- CharProtDB Description: Putative mitochondrial acyl-coA dehydrogenase involved in short-chain fatty acid beta-oxidation; required for growth on short-chain fatty acids; Source:AspGD
CHCOA_GEOMG / Q39QF4 Cyclohexane-1-carbonyl-CoA dehydrogenase; CHCoA dehydrogenase; EC 1.3.8.11 from Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15) (see paper)
Q39QF4 cyclohexane-1-carbonyl-CoA dehydrogenase (electron-transfer flavoprotein) (EC 1.3.8.11) from Geobacter metallireducens (see paper)
Gmet_3307 Acyl-CoA dehydrogenase-like from Geobacter metallireducens GS-15
42% identity, 97% coverage
- function: Acyl-CoA dehydrogenase involved in the anaerobic degradation of cyclohexane carboxylic acid (CHC) (PubMed:25112478). Catalyzes the 1,2-dehydrogenation of cyclohexane-1-carbonyl-CoA (CHCoA) to cyclohex- 1-ene-1-carbonyl-CoA (CHeneCoA) (PubMed:25112478). An alternative substrate, cyclohex-3-ene-1-carboxyl-CoA can be converted to the corresponding cyclohexadiene-1-carboxyl-CoA isomers (30% rate compared to CHC) (PubMed:25112478).
catalytic activity: cyclohexane-1-carbonyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = cyclohex-1-ene-1-carbonyl-CoA + reduced [electron-transfer flavoprotein] (RHEA:38935)
cofactor: FAD
subunit: Homotetramer. - Enzymes involved in a novel anaerobic cyclohexane carboxylic acid degradation pathway
Kung, Journal of bacteriology 2014 - “...genes encoding the putative CHCoA dehydrogenase (Gmet_3307), CHeneCoA dehydrogenase (Gmet_3306), and the CHCactivating CoA transferase (Gmet_3304) were...”
- “...(i) Preparation of cell extracts. Frozen E. coli cells (Gmet_3306 and Gmet_3307, 2 to 3 g wet cell mass per 5 ml; Gmet_3304, 10 g per 10 ml) were suspended in...”
PA14_54630 probable acyl-CoA dehydrogenase from Pseudomonas aeruginosa UCBPP-PA14
42% identity, 97% coverage
PSPA7_4774 acyl-CoA dehydrogenase from Pseudomonas aeruginosa PA7
42% identity, 97% coverage
AbA118F_0711 acyl-CoA dehydrogenase family protein from Acinetobacter baumannii
40% identity, 95% coverage
- Cerebrospinal fluid (CSF) augments metabolism and virulence expression factors in Acinetobacter baumannii
Martinez, Scientific reports 2021 - “...protein TatC AbA118F_2820 -1.86 3.9 E-02 Allantoin racemase AbA118F_2477 -1.87 4.6 E-10 Mg(2+)-transport-ATPase-associated protein MgtC AbA118F_0711 -1.89 5.4 E-16 Acyl-CoA dehydrogenase AbA118F_0704 -1.99 1.4 E-02 2-aminoethylphosphonate ABC transporter substrate-binding protein AbA118F_2199 -2.06 2.4 E-04 Protein co-occuring with molybdenum cofactor biosynthesis protein B AbA118F_0907 -2.14 5.2 E-20...”
- “...transporters (e.g. Mg2+transporters, AbA118F_2476 and AbA118F_2477) and catabolic proteins (such as AbA118F_1645 Alkaline Phosphatase and AbA118F_0711 Acyl-CoA dehydrogenase) (Table 1 and Supplementary Table S1 ). Gene ontology (GO) analysis was next undertaken to identify molecular functions and biological pathways associated to A . baumannii s adaptive...”
H2KZG6 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial from Caenorhabditis elegans
36% identity, 88% coverage
CNN01550 acyl-CoA oxidase from Cryptococcus neoformans var. neoformans JEC21
38% identity, 87% coverage
MAV_2590 putative acyl-CoA dehydrogenase from Mycobacterium avium 104
MAV_RS12365, OCU_RS31935 acyl-CoA dehydrogenase family protein from Mycobacterium intracellulare ATCC 13950
42% identity, 98% coverage
Rru_A1835 Butyryl-CoA dehydrogenase from Rhodospirillum rubrum ATCC 11170
Q2RTB0 Butyryl-CoA dehydrogenase from Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIMB 8255 / S1)
42% identity, 98% coverage
E9Q5L3 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial from Mus musculus
38% identity, 76% coverage
SCO2779 acyl-CoA dehydrogenase from Streptomyces coelicolor A3(2)
41% identity, 97% coverage
- Origin of the 3-methylglutaryl moiety in caprazamycin biosynthesis
Bär, Microbial cell factories 2022 - “...facilitating this step have also been reported for S. coelicolor J802 encoded by acdH ( sco2779 ) and for S. avermitilis ATCC 31272 encoded by fadE4 ( SAVERM_5275 ) [ 34 ]. Next, a 3-methylcrotonyl-CoA carboxylase complex consisting of subunits and (LiuD and LiuB) generates 3-methylglutaconyl-CoA...”
- “...( liuR ). BLAST analysis of S. coelicolor M1154 revealed genes homologue to liuA ( sco2779 ), liuB ( sco2776 ), liuD ( sco2777 ) and liuE ( sco2778 ) (Additional file 1 : Fig. S6). No homologue was found for liuC in this cluster though,...”
- A Novel Two-Component System, Encoded by the sco5282/sco5283 Genes, Affects Streptomyces coelicolor Morphology in Liquid Culture
Arroyo-Pérez, Frontiers in microbiology 2019 - “...I 1.85E-15 1.16E-01 0.00E+00 SCO2778 Hydroxymethylglutaryl-CoA lyase 1.96 Amino acid degradation I 2.54E-13 2.75E-01 1.06E-03 SCO2779 Acyl-CoA dehydrogenase 2.08 Amino acid degradation I 6.17E-15 1.50E-01 0.00E+00 SCO4800 Isobutiryl-CoA mutase 1.16 Amino acid degradation I 4.36E-05 2.09E-04 2.03E-03 SCO5398 Methylmalonyl-CoA epimerase 1.38 Amino acid degradation I 5.03E-07...”
- Deciphering the regulon of Streptomyces coelicolor AbrC3, a positive response regulator of antibiotic production
Rico, Applied and environmental microbiology 2014 - “...also significantly downregulated. The acdH gene (SCO2779), encoding an acyl-coenzyme A (acyl-CoA) dehydrogenase involved in branched-amino-acid catabolism in...”
- “...3). These included the downregulated genes acdH (SCO2779), encoding acyl-CoA dehydrogenase; absR1 (SCO6992), encoding an activator of secondary metabolism; afsS...”
- The ROK family regulator Rok7B7 pleiotropically affects xylose utilization, carbon catabolite repression, and antibiotic production in streptomyces coelicolor
Świątek, Journal of bacteriology 2013 - “...amino acids (SCO2008 to SCO2012 and SCO2776 to SCO2779) and an enolase (SCO7638) were 2- to 3-fold enhanced in the mutant. Furthermore, the solute...”
XP_022830593 short-chain specific acyl-CoA dehydrogenase, mitochondrial-like isoform X1 from Spodoptera litura
39% identity, 91% coverage
G8E09_11790 acyl-CoA dehydrogenase family protein from Acinetobacter pittii
40% identity, 95% coverage
- Phenotypic Variation and Carbapenem Resistance Potential in OXA-499-Producing Acinetobacter pittii
Zhang, Frontiers in microbiology 2020 - “...0.0001 0.0061 G8E09_08620 Acyl-CoA dehydrogenase 2.39 0.0004 0.0138 G8E09_08600 OprD family porin 2.37 0.0000 0.0000 G8E09_11790 Acyl-CoA dehydrogenase 2.35 0.0000 0.0013 G8E09_14960 Trehalose-6-phosphate synthase 2.33 0.0012 0.0314 G8E09_12910 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylatedehydrogenase 2.25 0.0000 0.0009 G8E09_10090 2-oxo acid dehydrogenase subunit E2 2.24 0.0000 0.0012 G8E09_07160 Type 1 glutamine amidotransferase...”
Theos_1509 acyl-CoA dehydrogenase family protein from Thermus oshimai JL-2
39% identity, 98% coverage
SCO1428 acyl-CoA dehydrogenase from Streptomyces coelicolor A3(2)
42% identity, 97% coverage
- Coelimycin Synthesis Activatory Proteins Are Key Regulators of Specialized Metabolism and Precursor Flux in Streptomyces coelicolor A3(2)
Bednarz, Frontiers in microbiology 2021 - “...(FabD), SCO2388 (FabH), SCO2390 (FabF), SCO4681, SCO6468, SCO6564 (FabH2), SCO6717 and degradation group members were: SCO1428, SCO1705, SCO1750, SCO4006, SCO6195 (MACS1), SCO6196 (FadD1), SCO6966, and SCO6968 ( Kanehisa et al., 2016 ). The first step of lipid degradation is the synthesis of fatty acyl-CoA. We have...”
PADG_06805 uncharacterized protein from Paracoccidioides brasiliensis Pb18
C1GHR9 short-chain 2-methylacyl-CoA dehydrogenase from Paracoccidioides brasiliensis (strain Pb18)
38% identity, 85% coverage
- Prediction of Conserved Peptides of Paracoccidioides for Interferon-γ Release Assay: The First Step in the Development of a Lab-Based Approach for Immunological Assessment during Antifungal Therapy
Rosa, Journal of fungi (Basel, Switzerland) 2020 - “...01 Carrier ADP/ATP PAAG_08620 0.0 100% 97% Acyl-CoA dehydrogenase PAAG_03116 0.0 98% 100% Acyl-CoA dehydrogenase PADG_06805 0.0 100% 98% Acyl CoA dehydrogenase PADG_07604 0.0 100% 97% Acyl CoA hydratase PAAG_06309 0.0 97% 100% Actin F protein subunit uptake protein PADG_07756 0.0 100% 100% Alcohol dehydrogenase PADG_01174...”
- Effect of Nitrosative Stress on the S-Nitroso-Proteome of Paracoccidioides brasiliensis
Navarro, Frontiers in microbiology 2020 - “...PADG_06546 C1GGV9 Puromycin-sensitive aminopeptidase 123.33 PADG_02764 C1G6F9 Uncharacterized protein 118.76 PADG_00451 C1G0R1 Glucose-6-phosphate isomerase 107.41 PADG_06805 C1GHR9 Acyl-CoA dehydrogenase 106.03 BNA5 C1G0F9 Kynureninase 100.76 PADG_02343 C1G2H7 Uncharacterized protein 86.52 PADG_02030 C1G514 Hsp90 co-chaperone Cdc37 74.29 PADG_04949 C1GBE8 Threonine-tRNA ligase 44.00 PADG_07435 C1GJJ9 Uncharacterized protein 35.30 PADG_03325...”
- “...biosynthesis, such as heat shock protein (PADG_02895), saccharopine dehydrogenase (PADG_06144), puromycin-sensitive aminopeptidase (PADG_06546), acyl-CoA dehydrogenase (PADG_06805), glucose-6-phosphate isomerase (PADG_00451), kynureninase (PADG_00349), mitochondrial 2-methylisocitrate lyase (PADG_04709), and aminomethyltransferase (PADG_02914). This profile is in keeping with the proliferative pattern previously found. In the group treated with high levels...”
- Differential Metabolism of a Two-Carbon Substrate by Members of the Paracoccidioides Genus
Baeza, Frontiers in microbiology 2017 - “...in Pb 01 and Pb EPM83 (PAAG_06329; PAAG_02664; PAAG_05454; PAAG_03116; PAAG_06309; PAAG_06392; PAAG_01557; PADG_01228; PADG_01687; PADG_06805; PADG_07023; PADG_06721; PADG_01209; PADG_02527), producing acetyl-CoA and propionyl-CoA. Acetyl-CoA can be consumed in the glyoxylate cycle for biosynthetic purposes or in the TCA cycle to generate cellular energy as reduced...”
- “...the entry of acyl fatty acid into the mitochondria, and acylCoA dehydrogenase mitochondrial (PAAG_05454; PABG_01791; PADG_06805), which catalyzes the initial step in each cycle of fatty acid -oxidation, were up-regulated in Pb 01, Pb 03, Pb 339, and Pb EPM83, suggesting higher fatty acid degradation in...”
- Effect of Nitrosative Stress on the S-Nitroso-Proteome of Paracoccidioides brasiliensis
Navarro, Frontiers in microbiology 2020 - “...C1GGV9 Puromycin-sensitive aminopeptidase 123.33 PADG_02764 C1G6F9 Uncharacterized protein 118.76 PADG_00451 C1G0R1 Glucose-6-phosphate isomerase 107.41 PADG_06805 C1GHR9 Acyl-CoA dehydrogenase 106.03 BNA5 C1G0F9 Kynureninase 100.76 PADG_02343 C1G2H7 Uncharacterized protein 86.52 PADG_02030 C1G514 Hsp90 co-chaperone Cdc37 74.29 PADG_04949 C1GBE8 Threonine-tRNA ligase 44.00 PADG_07435 C1GJJ9 Uncharacterized protein 35.30 PADG_03325 C1G820...”
PA4435 probable acyl-CoA dehydrogenase from Pseudomonas aeruginosa PAO1
39% identity, 97% coverage
H16_B1371 Acyl-CoA dehydrogenase, short-chain specific from Ralstonia eutropha H16
39% identity, 96% coverage
ivd1 / CAC08233.1 isovaleryl-CoA dehydrogenase from Solanum tuberosum (see paper)
37% identity, 91% coverage
Rv2500c POSSIBLE ACYL-CoA DEHYDROGENASE FADE19 (MMGC) from Mycobacterium tuberculosis H37Rv
40% identity, 95% coverage
MBCD_SOLTU / Q9FS88 2-methylacyl-CoA dehydrogenase, mitochondrial; 2-methylbutanoyl-CoA dehydrogenase; 2-methylbutyryl-CoA dehydrogenase; 2MBCD; Isovaleryl-CoA dehydrogenase 1; St-IVD1; EC 1.3.8.5 from Solanum tuberosum (Potato) (see 2 papers)
37% identity, 91% coverage
- function: Short/branched-chain acyl-CoA dehydrogenase (SBCAD). Uses 2- methylbutanoyl-CoA as substrate. Minor activity with the straight-chain substrates, butanoyl-CoA, valeryl-CoA, hexanoyl-CoA, and octanoyl-CoA but no activity with isovaleryl-CoA.
catalytic activity: 2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein] (RHEA:43780)
cofactor: FAD
subunit: Homotetramer.
acdH / Q9XCG5 acyl-CoA dehydrogenase subunit (EC 1.3.8.4; EC 1.3.8.5) from Streptomyces avermitilis (see 3 papers)
SAVERM_5275 acyl-CoA dehydrogenase family protein from Streptomyces avermitilis MA-4680 = NBRC 14893
41% identity, 97% coverage
- Origin of the 3-methylglutaryl moiety in caprazamycin biosynthesis
Bär, Microbial cell factories 2022 - “...by acdH ( sco2779 ) and for S. avermitilis ATCC 31272 encoded by fadE4 ( SAVERM_5275 ) [ 34 ]. Next, a 3-methylcrotonyl-CoA carboxylase complex consisting of subunits and (LiuD and LiuB) generates 3-methylglutaconyl-CoA by transfer of acetyl-CoA onto 3-methylcrotonyl-CoA. The identification of a similar -subunit...”
CNAG_06431 acyl-CoA oxidase from Cryptococcus neoformans var. grubii H99
38% identity, 87% coverage
- Cryptococcus neoformans resists to drastic conditions by switching to viable but non-culturable cell phenotype
Hommel, PLoS pathogens 2019 - “...4.00E-05 Biosynthesis of secondary metabolites CNAG_00484, CNAG_00490, CNAG_00524, CNAG_00797, CNAG_03067, CNAG_02489, CNAG_06628, CNAG_04531, CNAG_04217, CNAG_04688, CNAG_06431 2.60E-04 Peroxisome CNAG_00537, CNAG_03067, CNAG_03019, CNAG_06551, CNAG_07747 2.90E-04 Metabolic pathways CNAG_00484, CNAG_00490, CNAG_00524, CNAG_00797, CNAG_00826, CNAG_03067, CNAG_03019, CNAG_01540, CNAG_02489, CNAG_06628, CNAG_07747, CNAG_05653, CNAG_05303, CNAG_04531, CNAG_04351, CNAG_04217, CNAG_04688 3.60E-04 beta-Alanine metabolism...”
- Characterization of Lipids and Proteins Associated to the Cell Wall of the Acapsular Mutant Cryptococcus neoformans Cap 67
Longo, The Journal of eukaryotic microbiology 2015 - “...- CNAG_05721 multifunctional beta-oxidation protein - Hc CNAG_05069 ubiquinol-cytochrome c reductase sub. 10 - - CNAG_06431 acyl-CoA oxidase - - Signaling CNAG_01523 CMGC/MAPK/P38 protein kinase - Sc CNAG_05235 protein BMH2 Ca PbSc CnHcPbSc CNAG_05465 guanine nucleotide-binding protein Af Ca PbSc HcSc Nucleosomeassembly CNAG_06745 histone H3 -...”
- The transcriptional response of Cryptococcus neoformans to ingestion by Acanthamoeba castellanii and macrophages provides insights into the evolutionary adaptation to the mammalian host
Derengowski, Eukaryotic cell 2013 - “...2.70596 2.58975 Lipid metabolism CNAG_03019 CNAG_06431 CNAG_00490 CNAG_03666 CNAG_06551 CNAG_07747 CNAG_02562 CNAG_02045 CNAG_03393 CNAG_05721 CNAG_01116...”
SCLAV_0665 acyl-CoA dehydrogenase family protein from Streptomyces clavuligerus
42% identity, 95% coverage
- Comparative Transcriptome Analysis of Streptomyces Clavuligerus in Response to Favorable and Restrictive Nutritional Conditions
Pinilla, Antibiotics (Basel, Switzerland) 2019 - “...via argH (argininosuccinate lyase), whose expression also increased in SB-M. TCA-cycle-associated genes e.g., acyl-CoA dehydrogenase (SCLAV_0665), malate dehydrogenase (SCLAV_3742) and central metabolism-associated genes e.g., those coding for pyruvate dehydrogenase (SCLAV_1401) and aldehyde dehydrogenase (SCLAV_5677), were differentially expressed. Arginine metabolism has also been extensively studied in S....”
- “...1.108 10 2 Carbon metabolism SCLAV_5677 Aldehyde dehydrogenase 5.151 9.470 10 12 3.370 10 9 SCLAV_0665 Acyl-CoA dehydrogenase 2.943 2.290 10 4 6.964 10 3 SCLAV_3742 Malate dehydrogenase 2.146 1.345 10 3 2.800 10 2 SCLAV_1401 Pyruvate dehydrogenase E1 component 2.107 1.630 10 3 3.202 10...”
CC1350 acyl-CoA dehydrogenase from Caulobacter crescentus CB15
40% identity, 98% coverage
C6369_RS06395 acyl-CoA dehydrogenase from Rhodococcus rhodochrous
39% identity, 97% coverage
- Catabolism of Alkylphenols in Rhodococcus via a Meta-Cleavage Pathway Associated With Genomic Islands
Levy-Booth, Frontiers in microbiology 2019 - “...acid degradation pathway (Jimenez-Diaz et al., 2017 ) encoded by butyryl-CoA dehydrogenase genes (locus tags: C6369_RS06395, C6369_RS20140, C6369_RS07820, C6369_RS05465), enoylCoA hydratase (C6369 _RS19405, C6369_RS19860), 3-hydroxybutyryl-CoA dehydrogenase (C6369_RS03325, C6369_RS06400), and acetyl-CoA acyltransferase (C6369_RS17095, C6369_RS15900, C6369_RS19850) ( Supplementary Figure 2 ). The catABC cluster encoding catechol 1,2-dioxygenase and...”
C9Z7Q3 Acyl-CoA dehydrogenase from Streptomyces scabiei (strain 87.22)
42% identity, 94% coverage
- Comparative secretome analysis of Streptomyces scabiei during growth in the presence or absence of potato suberin
Komeil, Proteome science 2014 - “...d Acetyl CoA acyl transferase 0.010.01 0.100.09 0.140.07 C9YYE5 SCAB_70541 Lipolytic enzyme 0.070.09 nd nd C9Z7Q3 SCAB_75771 d Acyl-CoA dehydrogenase 0.020.01 0.020.03 nd Degradation of aromatic compounds C9Z2P6 SCAB_57301 3-oxo-5.6-dehydrosuberyl-CoA semialdehyde dehydrogenase 0.130.17 nd nd Carbohydrate metabolism C9YSY4 SCAB_4561 Glycosyl hydrolase 0.000.00 0.020.02 0.000.00 C9YVM5 SCAB_5761...”
- “...have been detected only in the supernatant of CSM (C9YTK3, C9YYE5, C9YY49, C9ZD66, C9ZGV4, C9Z6Y2, C9Z7Q3 and C9Z776) or were more abundant in this medium (C9ZCR0, C9Z5Z2 and C9Z707). Four of these proteins, a protein from the esterase-lipase family (C9YTK3), a lipolytic enzyme (C9YYE5), a glycerophosphoryl...”
SCLAV_1946 acyl-CoA dehydrogenase family protein from Streptomyces clavuligerus
40% identity, 97% coverage
G7CDN2 Acyl-CoA dehydrogenase domain-containing protein from Mycolicibacterium thermoresistibile (strain ATCC 19527 / DSM 44167 / CIP 105390 / JCM 6362 / NCTC 10409 / 316)
42% identity, 95% coverage
VPA1121 putative acyl-CoA dehydrogenase from Vibrio parahaemolyticus RIMD 2210633
40% identity, 98% coverage
- Fitness and transcriptomic analysis of pathogenic Vibrio parahaemolyticus in seawater at different shellfish harvesting temperatures
Liu, Microbiology spectrum 2023 - “...GCTTCAAGAAGAGCTACCAGCTACGGCGCGAATAGAGTGAGAGTAT 93 This study trh+_10&30 VP0474 Probable membrane transporter protein GGTGGAGTTGGTTTCTACGATGCCATACAGGTAACCCTGCTAGAAC 180 This study tdh+_10&30 VPA1121 Putative acyl-CoA dehydrogenase GGTGGCTATGGCTACATCAAAGGCTCTACGTCTTCCGTGAGTAAAC 136 This study tdh+_10&30 VPA1060 Putative two-component response regulatory proteins GCTCTTCAACCTTGGATTGACCTGTACGCGTGTTCCTCATCTAC 166 This study trh+_10&30tdh+_10&30 glgC VPA0833 Glucose-1-phosphate adenylyltransferase GAAAACCCACCTACTCTTCCAGACGTCATGGCTAGACGTTTCCAGT 129 This study trh+_10&30tdh+_10&30 ACKNOWLEDGMENTS This...”
Mlut_06870 acyl-CoA dehydrogenase family protein from Micrococcus luteus NCTC 2665
40% identity, 94% coverage
- Impact of Branched-Chain Amino Acid Catabolism on Fatty Acid and Alkene Biosynthesis in Micrococcus luteus
Surger, Frontiers in microbiology 2018 - “...02900:kan trpE16 with deletion of Mlut_02900; Kan R This study 06870:kan trpE16 with deletion of Mlut_06870; Kan R This study ope trpE16 P up 13230 (replacement of native oleABCD gene cluster promoter by strong succinate dehydrogenase promoter) This study ope 02880:hyg ope with deletion of Mlut_02880;...”
- “...in gene clusters potentially involved in the degradation of BCAAs, i.e., ORFs Mlut_02820, Mlut_02900 and Mlut_06870. Mlut_02820 and Mlut_02900 were located near a set of genes which seem to encode almost all steps of the isoleucine/valine degradation pathways, and Mlut_06870 was found in a gene cluster...”
NGR_b20870 probable acyl-CoA dehydrogenase from Rhizobium sp. NGR234
42% identity, 98% coverage
W5PHF2 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial from Ovis aries
36% identity, 85% coverage
Swit_0650 acyl-CoA dehydrogenase domain-containing protein from Sphingomonas wittichii RW1
40% identity, 98% coverage
- Proteomic profiling of the dioxin-degrading bacterium Sphingomonas wittichii RW1
Colquhoun, Journal of biomedicine & biotechnology 2012 - “...Average ratio c t -test d 821 148551036 Swit_5089 Fumarylacetoacetate hydrolase 1.99 0.063 470 148553574 Swit_0650 Acyl-CoA dehydrogenase domain 1.74 0.031 161 148550568 Swit_5129 TonB-dependent receptor 1.59 0.086 a Arbitrary identifier for spot location (see Figure 2 ). b NCBI gi number. c Using internal standard...”
NGR_b20870 isobutyryl-CoA dehydrogenase from Sinorhizobium fredii NGR234
41% identity, 98% coverage
Tfu_1647 / Q47PD7 5-carboxy-2-pentenoyl-CoA reductase from Thermobifida fusca (strain YX) (see 2 papers)
Tfu_1647 acyl-CoA dehydrogenase from Thermobifida fusca YX
42% identity, 98% coverage
- Repurposing of waste PET by microbial biotransformation to functionalized materials for additive manufacturing
Kolitha, Journal of industrial microbiology & biotechnology 2023 - “...Mad123146) expressing five-step reverse adipate-degradation pathway (RADP) identified in Thermobifida fusca , including overexpression of Tfu_1647 by pTrc99A and deletion of succinate-CoA ligase to promote accumulation of succinyl-CoA Fed-batch fermentation Nylon-6, 6 production by polymerization Zhao et al. ( 2018 ) cis,cis -Muconic acid (MA) PET...”
- Microbial cell factories for bio-based biodegradable plastics production
Han, iScience 2022 - “...titer of up to 68 g/L from glycerol. 10 Overexpression of the key rate-limiting enzyme Tfu_1647 has been shown to be very important for the efficient production of adipic acid. Strategies such as elimination of by-product pathways and succinyl-CoA consumption pathways have also been used to...”
- Reverse β-oxidation pathways for efficient chemical production
Tarasava, Journal of industrial microbiology & biotechnology 2022 - “...PaaF, tdTER Acot8 Cheong et al. ( 2016 ) Glycerol Glutarate 36.5mmol/l Tfu_0875 Tfu_2399, Tfu_0067, Tfu_1647 Tfu_2576-7 Zhao et al. ( 2018 ) Glycerol C6C10 dicarboxylic acids 0.5g/l BktB BktB, FadB and egTer YdiI, AlkBGT, ChnD, and ChnE Clomburg et al. ( 2015 ) -Hydroxyacids Glycerol...”
- Implementation of Synthetic Pathways to Foster Microbe-Based Production of Non-Naturally Occurring Carboxylic Acids and Derivatives
Vila-Santa, Journal of fungi (Basel, Switzerland) 2021 - “...2,3-Dehydroadipyl-CoA hydratase (3); 4 .2.1.17 T. fusca Tfu_0067 Adipyl-CoA dehydrogenase (4) ; 1.1.1.35 T. fusca Tfu_1647 Adipyl-CoA thioesterase (5) T. fusca Tfu_2577 and 2576 3.83 mg/L [ 32 ] Reverse -oxidation followed by -reduction * E. coli 3-ketoacyl-CoA thiolase (6) 2.3.1.16 C. necator BktB Trans-enoyl-CoA reductase...”
- Biosynthesis of adipic acid in metabolically engineered Saccharomyces cerevisiae
Zhang, Journal of microbiology (Seoul, Korea) 2020 (PubMed)- “...by co-expressing genes of Tfu_ 0875, Tfu_2399, Tfu_0067, Tfu_1647, Tfu_2576, and Tfu_ 2576. The AA titer combined with biomass, cofactors and other by-products...”
- “...dehydrogenase (Tfu_0067), 5-carboxy-2-pentenoyl-CoA reductase (Tfu_1647), and adipyl-CoA synthetase (Tfu_2576-7), respectively (Fig. 1). Subsequently,...”
- Site-directed mutation to improve the enzymatic activity of 5-carboxy-2-pentenoyl-CoA reductase for enhancing adipic acid biosynthesis
Yang, Enzyme and microbial technology 2019 (PubMed)- “...6 genes: Tfu_0875, Tfu_2399, Tfu_0067, Tfu_1647, Tfu_2576 and Tfu_2577, which encodes -ketothiolase, 3-hydroxyacyl-CoA dehydrogenase, 3-hydroxyadipyl-CoA...”
- “...respectively. Of the genes in this pathway, Tfu_1647 is the limited step. Here, we constructed a homology model of 5-carboxy-2-pentenoyl-CoA reductase...”
- Metabolic engineering of Escherichia coli for producing adipic acid through the reverse adipate-degradation pathway
Zhao, Metabolic engineering 2018 (PubMed)- “...that the step catalyzed by 5-Carboxy-2-pentenoyl-CoA reductase (Tfu_1647) as the rate-limiting step of the RADP. Overexpression of Tfu_1647 by pTrc99A carried...”
- “...3-hydroxyadipyl-CoA dehydrogenase (Tfu_0067), 5-Carboxy-2-pentenoyl-CoA reductase (Tfu_1647), and adipyl-CoA synthetase (Tfu_2576-7). The ldhA , atoB , and...”
- Engineering Escherichia coli for Glutarate Production as the C5 Platform Backbone
Zhao, Applied and environmental microbiology 2018 - “...by expressing five enzymes (Tfu_0875, Tfu_2399, Tfu_0067, Tfu_1647, and Tfu_2576-7) for glutarate production (Fig. 1). The glutarate was detected, and 0.5...”
- “...3-hydroxyadipyl-CoA dehydrogenase (Tfu_0067), 5-carboxy-2-pentenoyl-CoA reductase (Tfu_1647), and adipyl-CoA synthetase (Tfu_2576-7). The arcA, ldhA, atoB,...”
- More
AF2244 acyl-CoA dehydrogenase (acd-11) from Archaeoglobus fulgidus DSM 4304
37% identity, 94% coverage
- Assessment of the Carbon Monoxide Metabolism of the Hyperthermophilic Sulfate-Reducing Archaeon Archaeoglobus fulgidus VC-16 by Comparative Transcriptome Analyses
Hocking, Archaea (Vancouver, B.C.) 2015 - “...genes in the category fatty acid metabolism (I) encoding: enoyl-CoA hydratase (AF0963), acyl-CoA dehydrogenase (AF0964, AF2244), acetyl-CoA acetyltransferase (AF0967, AF2243), and acetyl-CoA synthetase (AF1287). Other upregulated transcripts encode enzymes involved in oxidation of uneven fatty acids/propionate metabolism, the putative methylmalonyl mutases (AF1288a, -b and AF2219). Finally,...”
Q7S9I3 short-chain 2-methylacyl-CoA dehydrogenase from Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
37% identity, 86% coverage
Sama_1362 Isovaleryl-CoA dehydrogenase (EC 1.3.8.4) from Shewanella amazonensis SB2B
36% identity, 97% coverage
- mutant phenotype: Specifically important for utilizing L-Leucine. Automated validation from mutant phenotype: the predicted function (RXN0-2301) was linked to the condition via a MetaCyc pathway. This annotation was also checked manually.
7w0jE / A0A4D5XMK4 Acyl-coa dehydrogenase, tfu_1647
42% identity, 97% coverage
- Ligand: [[(2r,3s,4r,5r)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2r,3s,4s)-5-azanyl-2,3,4-tris(oxidanyl)pentyl] hydrogen phosphate (7w0jE)
PGA1_c10280 Isovaleryl-CoA dehydrogenase (EC 1.3.8.4) from Phaeobacter inhibens DSM 17395
37% identity, 97% coverage
- mutant phenotype: Specifically important for utilizing L-Leucine. Automated validation from mutant phenotype: the predicted function (RXN0-2301) was linked to the condition via a MetaCyc pathway. This annotation was also checked manually.
FNP_2146 acyl-CoA dehydrogenase family protein from Fusobacterium polymorphum ATCC 10953
39% identity, 97% coverage
- Genome sequence of Fusobacterium nucleatum subspecies polymorphum - a genetically tractable fusobacterium
Karpathy, PloS one 2007 - “...2226995 2228584 von Willebrand factor domain protein FNP_1921 2263322 2265424 vacB ribonuclease R Butyrate fermentation FNP_2146 62092 60956 butyryl-CoA dehydrogenase FNP_0790 1158356 1159132 3-hydroxybutyryl-CoA dehydratase FNP_0791 1159148 1159987 fadB 3-hydroxybutyryl-CoA dehydrogenase FNP_0969 1326816 1326151 atoA butyrate-acetoacetate CoA-transferase, beta subunit FNP_0970 1327487 1326834 atoD butyrateacetoacetate CoA-transferase, alpha...”
PAAG_05454 acyl-CoA dehydrogenase from Paracoccidioides lutzii Pb01
37% identity, 85% coverage
- Differential Metabolism of a Two-Carbon Substrate by Members of the Paracoccidioides Genus
Baeza, Frontiers in microbiology 2017 - “...the beta-oxidation of fatty acids mainly functions in Pb 01 and Pb EPM83 (PAAG_06329; PAAG_02664; PAAG_05454; PAAG_03116; PAAG_06309; PAAG_06392; PAAG_01557; PADG_01228; PADG_01687; PADG_06805; PADG_07023; PADG_06721; PADG_01209; PADG_02527), producing acetyl-CoA and propionyl-CoA. Acetyl-CoA can be consumed in the glyoxylate cycle for biosynthetic purposes or in the TCA...”
- “...related to the entry of acyl fatty acid into the mitochondria, and acylCoA dehydrogenase mitochondrial (PAAG_05454; PABG_01791; PADG_06805), which catalyzes the initial step in each cycle of fatty acid -oxidation, were up-regulated in Pb 01, Pb 03, Pb 339, and Pb EPM83, suggesting higher fatty acid...”
- Proteomic profile response of Paracoccidioides lutzii to the antifungal argentilactone
Prado, Frontiers in microbiology 2015 - “...dehydrogenase flavoprotein subunit, mitochondrial PAAG_01725 1798.19 0.827 Oxidation of fatty acids Short-chain specific acyl-CoA dehydrogenase PAAG_05454 1028.15 * Transport Carbonic anhydrase PAAG_05716 854.25 0.795 Clathrin light chain PAAG_08252 1049.51 0.741 GTP-binding nuclear protein ran-1 PAAG_04651 3676.19 0.527 Nipsnap family protein PAAG_05960 4593.91 0.677 Vesicular-fusion protein sec17...”
SO3561_09667 acyl-CoA dehydrogenase family protein from Streptomyces olivochromogenes
42% identity, 95% coverage
YP_353229 Acyl-CoA dehydrogenase from Rhodobacter sphaeroides 2.4.1
41% identity, 98% coverage
- A Chemo-Enzymatic Road Map to the Synthesis of CoA Esters
Peter, Molecules (Basel, Switzerland) 2016 - “...expression vector pET28b generating the N-terminal His 6 tagged expression construct pTE423. The isobutyryl-CoA dehydrogenase YP_353229 gene from Rhodobacter sphaeroides was amplified with the forward primer CGGATCG CATATG GATTTCGCGCTGAGCG AG and the reverse primer GTACAT GAATTC TCATGCGGCCCCCAAGGC introducing a NdeI and an EcoRI restriction site. It...”
IVD_SOLTU / Q9FS87 Isovaleryl-CoA dehydrogenase, mitochondrial; IVD; Isovaleryl-CoA dehydrogenase 2; St-IVD2; EC 1.3.8.4 from Solanum tuberosum (Potato) (see 2 papers)
Q9FS87 isovaleryl-CoA dehydrogenase (EC 1.3.8.4) from Solanum tuberosum (see paper)
35% identity, 91% coverage
- function: Involved in the catabolism of amino acids. Uses isovaleryl- CoA as substrate. Minor activity detected with 2-methylpalmitoyl-CoA or 2-methylbutanoyl-CoA, but no activity with short- and medium-straight chain acyl-CoA esters or with 2-methylhexanoyl-CoA.
catalytic activity: 3-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = 3-methyl-(2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein] (RHEA:12276)
cofactor: FAD
subunit: Homotetramer.
SPO2793 isovaleryl-CoA dehydrogenase from Ruegeria pomeroyi DSS-3
37% identity, 98% coverage
- Diel investments in metabolite production and consumption in a model microbial system
Uchimiya, The ISME journal 2022 - “...acid derivative Betaine SPO3186 opuD Glycine-betaine transporter 1.6 (n.s.) [ 25 ] Amino Acid Leucine SPO2793 ivD isovaleryl-CoA dehydrogenase 2.6 SPO2789 mccA methylcrotonyl-CoA carboxylase, alpha subunit 3.1 SPO2790 mccB methylcrotonyl-CoA carboxylase, beta subunit 3.4 SPO0390 glutamate/leucine/phenylalanine/valine dehydrogenase 1.2 (n.s.) Amino acid derivative Ectoine/ 5-hydroxyectoine SPO1146 uehB...”
SDRG_07258 short/branched chain acyl-CoA dehydrogenase from Saprolegnia diclina VS20
39% identity, 87% coverage
SPRG_03679 hypothetical protein from Saprolegnia parasitica CBS 223.65
39% identity, 89% coverage
- Characterizing the Mechanisms of Metalaxyl, Bronopol and Copper Sulfate against Saprolegnia parasitica Using Modern Transcriptomics
Wang, Genes 2022 - “...pathways. PPI network analysis screened out three important proteins, and their corresponding genes were SPRG_08456, SPRG_03679 and SPRG_10775. Our results indicate that three antimicrobials inhibit S. parasitica growth by affecting multiple biological functions, including protein synthesis, oxidative stress, lipid metabolism and energy metabolism. Additionally, the screened...”
- “...protein and connected by 100 edges ( Figure 6 ). SDRG_06419 (SPRG_08456), followed by SDRG_07258 (SPRG_03679), SDRG_01993 (SPRG_04185), SDRG_06022 (SPRG_10775) and SDRG_06773 (SPRG_05141) presented the highest scores for degree centrality (DC), indicating that they were the most important factors for the network. 3.7. Verification of DEGs...”
ivd2 / CAC08234.1 isovaleryl-CoA dehydrogenase, partial from Solanum tuberosum (see paper)
35% identity, 94% coverage
lpp0931 hypothetical protein from Legionella pneumophila str. Paris
38% identity, 98% coverage
U876_10345 acyl-CoA dehydrogenase family protein from Aeromonas hydrophila NJ-35
40% identity, 98% coverage
HMPREF0397_RS02330 acyl-CoA dehydrogenase family protein from Fusobacterium nucleatum subsp. nucleatum ATCC 23726
FN1535 Acyl-CoA dehydrogenase, short-chain specific from Fusobacterium nucleatum subsp. nucleatum ATCC 25586
38% identity, 97% coverage
- The Fused Methionine Sulfoxide Reductase MsrAB Promotes Oxidative Stress Defense and Bacterial Virulence in Fusobacterium nucleatum
Scheible, mBio 2022 - “...protein 9.35 HMPREF0397_RS06445 NAD(P)/FAD-dependent oxidoreductase 7.08 HMPREF0397_RS03635 Urocanate hydratase 6.97 HMPREF0397_RS03630 hutH Histidine ammonia-lyase 6.57 HMPREF0397_RS02330 Acyl-CoA b dehydrogenase 6.57 HMPREF0397_RS02335 Electron transfer flavoprotein subunit beta 6.27 HMPREF0397_RS02340 Electron transfer flavoprotein subunit alpha 6.04 HMPREF0397_RS04970 Formate-tetrahydrofolate ligase 5.85 HMPREF0397_RS07365 ftcD Glutamate formimidoyltransferase 5.27 HMPREF0397_RS02930 Glu/Leu/Phe/Val dehydrogenase...”
- The Pathogenicity of Fusobacterium nucleatum Modulated by Dietary Fibers-A Possible Missing Link between the Dietary Composition and the Risk of Colorectal Cancer
Nawab, Microorganisms 2023 - “...(Hbd (FN1019), (R) and (S)-3-Hydroxybutanoyl-CoA (CroR (FN0816), cro (FN1020)), and Crotonyl-CoA (Bcd (FN1424, FN0783, and FN1535) to yield Butyryl-CoA; from Butyryl-CoA through the butyryl-CoA, the acetate CoA transferase (But: atoD/atoA) route (FN1856 and FN1857) finally yielded butyrate, and almost all the genes involved were identified, which...”
- Proteomics of Fusobacterium nucleatum within a model developing oral microbial community
Hendrickson, MicrobiologyOpen 2014 - “...butanoate acetoacetate CoA transferase alpha subunit (FN1857), and butyryl-CoA dehydrogenase (three homologs FN00783, FN 1424, FN1535), the stress protein DnaK (FN0116), and several proteins involved in translation. Again we saw no change in the stress protein, DnaK, but the metabolic proteins showed increased levels in one...”
Sfum_1371 Butyryl-CoA dehydrogenase from Syntrophobacter fumaroxidans MPOB
41% identity, 97% coverage
- Comparative proteome analysis of propionate degradation by Syntrophobacter fumaroxidans in pure culture and in coculture with methanogens
Sedano-Núñez, Environmental microbiology 2018 - “...or crotonate, complexes similar to Bcd/Etf have been predicted from the genome. The acylCoA subunit (Sfum_1371) of one of these complexes was abundant in all conditions, while the Etf subunits (Sfum_1372 and Sfum_1373) were detected in lower levels, and the beta subunit was not detected at...”
- “...Sfum_0107 was abundant in all conditions at similar levels than the acylCoA subunit from gene Sfum_1371. (Supporting Information Fig. S2) Two additional paralogs coding for AcylCoA/Etf complexes were found in the genome (Sfum_368688 and Sfum_39293931), but not detected in our proteomic analysis. Finally, NfnAB (Sfum_21502151), another...”
SMb20753 putative acyl-CoA dehydrogenase protein from Sinorhizobium meliloti 1021
41% identity, 98% coverage
BAB2_1047 Acyl-CoA dehydrogenase, C-terminal:Acyl-CoA dehydrogenase, central domain:Acyl-CoA dehydrogenase, N-terminal from Brucella melitensis biovar Abortus 2308
39% identity, 93% coverage
H16_B0485 Acyl-CoA dehydrogenase, short-chain specific from Ralstonia eutropha H16
40% identity, 91% coverage
PS417_17015 Isovaleryl-CoA dehydrogenase (EC 1.3.8.4) from Pseudomonas simiae WCS417
36% identity, 98% coverage
- mutant phenotype: Specifically important for utilizing L-Leucine. Automated validation from mutant phenotype: the predicted function (RXN0-2301) was linked to the condition via a MetaCyc pathway. This annotation was also checked manually.
C5C8N7 Acyl-CoA dehydrogenase from Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / CCM 169 / CCUG 5858 / IAM 1056 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230)
Mlut_02820 acyl-CoA dehydrogenase family protein from Micrococcus luteus NCTC 2665
39% identity, 98% coverage
AO353_20350 Isovaleryl-CoA dehydrogenase (EC 1.3.8.4) from Pseudomonas fluorescens FW300-N2E3
36% identity, 98% coverage
- mutant phenotype: Specifically important for utilizing L-Leucine. Automated validation from mutant phenotype: the predicted function (RXN0-2301) was linked to the condition via a MetaCyc pathway. This annotation was also checked manually.
TTHA0892 acyl-CoA dehydrogenase from Thermus thermophilus HB8
41% identity, 66% coverage
MAP3651c FadE3_2 from Mycobacterium avium subsp. paratuberculosis str. k10
40% identity, 93% coverage
- Mammalian cell entry operons; novel and major subset candidates for diagnostics with special reference to Mycobacterium avium subspecies paratuberculosis infection
Hemati, The veterinary quarterly 2019 - “...in MAP 11 MAP3936 Chaperonin GroEL 12 MAP4143 Elongation factor Tu 13 MAP3024c HupB 14 MAP3651c FadE3_2 15 MAP1997 Acyl carrier protein 16 MAP3968 Heparin-binding hemagglutinin adhesin-like protein 17 MAP1122 MIHF 18 MAP1589c Alkylhydroperoxidase C 19 MAP1506 Hypothetical protein 20 MAP3362c S-adenosyl-L-homocysteine hydrolase 21 MAP1519 Hypothetical...”
- Recent Trends in System-Scale Integrative Approaches for Discovering Protective Antigens Against Mycobacterial Pathogens
Rana, Frontiers in genetics 2018 - “...novel and more efficient vaccines against TB ( Monterrubio-Lpez, 2015 ). Eight proteins (MAP2698c, MAP2312c, MAP3651c, MAP2872c, MAP3523c, MAP0187c and the hypothetical proteins MAP3567 and MAP1168c) were also identified with highly immunogenic epitopes in the MAP as potential vaccine candidates for studying antibody and cell-mediated immune...”
- Description of a novel adhesin of Mycobacterium avium subsp. paratuberculosis
Viale, BioMed research international 2014 - “...Hypothetical protein Short-chain dehydrogenases/reductases 864 He and de Buck, 2010 (MAP) [ 34 ] 13 MAP3651c Rv0215c fadE3_2 Acyl-CoA dehydrogenase FadE3 1,218 He and de Buck, 2010 (MAP) [ 34 ] 7 MAP3692c Rv0242c fabG4 3-Ketoacyl reductase 1,365 He and de Buck, 2010 (MAP) [ 34...”
- Antigenicity of recombinant maltose binding protein-Mycobacterium avium subsp. paratuberculosis fusion proteins with and without factor Xa cleaving
Gurung, Clinical and vaccine immunology : CVI 2013 - “...MAP0516c, MAP1017c, MAP2698c, MAP2872c, MAP3190, MAP3577, MAP3651c MAP0187c, MAP0540, MAP1560, MAP1885c, MAP2411, MAP2487c, MAP2705c, MAP3007, MAP3538, MAP3567...”
- Key role for the alternative sigma factor, SigH, in the intracellular life of Mycobacterium avium subsp. paratuberculosis during macrophage stress
Ghosh, Infection and immunity 2013 - “...0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 MAP3651c MAP2585 MAP2580c MAP2306 MAP1593 MAP3337 MAP1553c MAP1554c MAP2175c MAP2642 MAP3763c MAP2174c MAP2178 MAP3740...”
- Host-Mycobacterium avium subsp. paratuberculosis interactome reveals a novel iron assimilation mechanism linked to nitric oxide stress during early infection
Lamont, BMC genomics 2013 - “...cell type infection) identified one fadD ( MAP2833c ) gene and one fadE gene ( MAP3651c ), indicating that beta-oxidation has just initiated within macrophages (Figure 6 ). Comparisons of infected co-cultured MAC-T cells against infected MAC-T cells, identified additional fadE gene ( MAP1458 ), enoyl...”
- In silico identification of epitopes in Mycobacterium avium subsp. paratuberculosis proteins that were upregulated under stress conditions
Gurung, Clinical and vaccine immunology : CVI 2012 - “...[encoded by desA2], MAP2312c [encoded by fadE19], MAP3651c [encoded by fadE3_2], MAP2872c [encoded by fabG5_2], MAP3523c [encoded by oxcA], MAP0187c [encoded...”
- “...are presented in Table 3. Five proteins (MAP2698c, MAP3567, MAP3651c, MAP3523c, and MAP2312c) were found to carry the largest numbers of MHC class I T cell...”
- Surface proteome of "Mycobacterium avium subsp. hominissuis" during the early stages of macrophage infection
McNamara, Infection and immunity 2012 - “...NA NA MAP1122 MAP3024c MAP4167 NA NA MAP0990 MAP3651c MAP1506 MAP1519 MAP2698c MAP1563c MAP3532 MAP3033c MAP3188 MAP1588c MAP2228 MAP2280c MAP1508 NA NA NA NA...”
- More
SMc01639 PUTATIVE ACYL-COA DEHYDROGENASE PROTEIN from Sinorhizobium meliloti 1021
38% identity, 97% coverage
- Characterization of l-Carnitine Metabolism in Sinorhizobium meliloti
Bazire, Journal of bacteriology 2019 - “...S. meliloti Rm2011 and were named Smc01637, Smc01638, Smc01639, Smc01640, and Smc01641. In summary, we considered that Smc01640 codes for BcoA/B, which forms...”
- “...45 7 3,000 693 kcat (s1)a 25.3 1.9 BcoC (Smc01639) -Butyrobetainyl-CoAe FADf 4.1 1.7 0.8 0.2 1.8 0.12 4.4 105 2.3 106 BcoD (Smc01641) Crotonobetainyl-CoA 20.5...”
- Proline betaine uptake in Sinorhizobium meliloti: Characterization of Prb, an opp-like ABC transporter regulated by both proline betaine and salinity stress
Alloing, Journal of bacteriology 2006 - “...unknown function; Smc01638, hydroxyacyl-CoA dehydrogenase; Smc01639, acyl-CoA dehydrogenase; Smc01640, acyl-CoA synthetase; Smc01641, enoyl-CoA hydratase;...”
BAB2_0214 Acyl-CoA dehydrogenase:Acyl-CoA dehydrogenase, C-terminal:Acyl-CoA dehydrogenase, central domain:Acyl-CoA dehydrogenase, N-te... from Brucella melitensis biovar Abortus 2308
37% identity, 97% coverage
- Molecular control of gene expression by Brucella BaaR, an IclR-type transcriptional repressor
Herrou, The Journal of biological chemistry 2018 - “...to WT (Fig. 3A). These four genes, bab2_0213, bab2_0214, bab2_0216, and bab2_0217, are contiguous and adjacent to baaR (bab2_0215). Genes bab2_0213, bab2_0214,...”
- “...ADP1 is involved in cis,cis-muconic acid uptake (39). bab2_0214 is annotated as an acyl-CoA dehydrogenase; this family of flavoJ. Biol. Chem. (2018) 293(19)...”
bglu_2g11300 Acyl-CoA dehydrogenase from Burkholderia glumae BGR1
38% identity, 95% coverage
- RNAseq-based Transcriptome Analysis of Burkholderia glumae Quorum Sensing
Kim, The plant pathology journal 2013 - “...R: TCTTGACGTTGTCGAGCTTCGTGT bglu_2g18750 aldehyde dehydrogenase F: GCCGATCCTCTACGTGCTGAAGTA R: AGATCGGTCGTAAACACGCACGAC bglu_2g18780 transferase F: TACAGCCTGGTCGGCATTCA R: GCATAGAACTCGATGTTGCCGC bglu_2g11300 acyl-CoA dehydrogenase F: ACATGGTGGCGATGGAGGAAATCT R:ATGGATCTGGTTGACGCAGAGATTG bglu_2g17540 MutT/nudix family protein F: ACTACGTGCTGATCGCGTTGCTGT R: TCGGAATGATTGATCTCGTGGGCA * reference gene Table 2. Expression profiling of genes involved in the flagellar assembly pathway in B....”
GAH_00591 acyl-CoA dehydrogenase family protein from Geoglobus ahangari
38% identity, 98% coverage
- The complete genome sequence and emendation of the hyperthermophilic, obligate iron-reducing archaeon "Geoglobus ahangari" strain 234(T)
Manzella, Standards in genomic sciences 2015 - “...dehydrogenase proteins, which in G. ahangari are putatively encoded by 11 genes (GAH_00179, GAH_00421, GAH_00484, GAH_00591, GAH_01331, GAH_01442, GAH_01601, GAH_01810, and GAH_02050). A water molecule is then added to trans-2-enoyl-CoA to form (3S)-3-hydroxyacyl-CoA in a reaction catalyzed by an enoyl-CoA hydratase, which in G. ahangari could...”
2z1qB / Q5SJW0 Crystal structure of acyl coa dehydrogenase
41% identity, 67% coverage
- Ligand: flavin-adenine dinucleotide (2z1qB)
SYN_00480 acyl-CoA dehydrogenase, short-chain specific from Syntrophus aciditrophicus SB
SYN_RS09650 glutaryl-CoA dehydrogenase Acd from Syntrophus aciditrophicus SB
38% identity, 98% coverage
For advice on how to use these tools together, see
Interactive tools for functional annotation of bacterial genomes.
The PaperBLAST database links 793,807 different protein sequences to 1,259,118 scientific articles. Searches against EuropePMC were last performed on March 13 2025.
PaperBLAST builds a database of protein sequences that are linked
to scientific articles. These links come from automated text searches
against the articles in EuropePMC
and from manually-curated information from GeneRIF, UniProtKB/Swiss-Prot,
BRENDA,
CAZy (as made available by dbCAN),
BioLiP,
CharProtDB,
MetaCyc,
EcoCyc,
TCDB,
REBASE,
the Fitness Browser,
and a subset of the European Nucleotide Archive with the /experiment tag.
Given this database and a protein sequence query,
PaperBLAST uses protein-protein BLAST
to find similar sequences with E < 0.001.
To build the database, we query EuropePMC with locus tags, with RefSeq protein
identifiers, and with UniProt
accessions. We obtain the locus tags from RefSeq or from MicrobesOnline. We use
queries of the form "locus_tag AND genus_name" to try to ensure that
the paper is actually discussing that gene. Because EuropePMC indexes
most recent biomedical papers, even if they are not open access, some
of the links may be to papers that you cannot read or that our
computers cannot read. We query each of these identifiers that
appears in the open access part of EuropePMC, as well as every locus
tag that appears in the 500 most-referenced genomes, so that a gene
may appear in the PaperBLAST results even though none of the papers
that mention it are open access. We also incorporate text-mined links
from EuropePMC that link open access articles to UniProt or RefSeq
identifiers. (This yields some additional links because EuropePMC
uses different heuristics for their text mining than we do.)
For every article that mentions a locus tag, a RefSeq protein
identifier, or a UniProt accession, we try to select one or two
snippets of text that refer to the protein. If we cannot get access to
the full text, we try to select a snippet from the abstract, but
unfortunately, unique identifiers such as locus tags are rarely
provided in abstracts.
PaperBLAST also incorporates manually-curated protein functions:
- Proteins from NCBI's RefSeq are included if a
GeneRIF
entry links the gene to an article in
PubMed®.
GeneRIF also provides a short summary of the article's claim about the
protein, which is shown instead of a snippet.
- Proteins from Swiss-Prot (the curated part of UniProt)
are included if the curators
identified experimental evidence for the protein's function (evidence
code ECO:0000269). For these proteins, the fields of the Swiss-Prot entry that
describe the protein's function are shown (with bold headings).
- Proteins from BRENDA,
a curated database of enzymes, are included if they are linked to a paper in PubMed
and their full sequence is known.
- Every protein from the non-redundant subset of
BioLiP,
a database
of ligand-binding sites and catalytic residues in protein structures, is included. Since BioLiP itself
does not include descriptions of the proteins, those are taken from the
Protein Data Bank.
Descriptions from PDB rely on the original submitter of the
structure and cannot be updated by others, so they may be less reliable.
(For SitesBLAST and Sites on a Tree, we use a larger subset of BioLiP so that every
ligand is represented among a group of structures with similar sequences, but for
PaperBLAST, we use the non-redundant set provided by BioLiP.)
- Every protein from EcoCyc, a curated
database of the proteins in Escherichia coli K-12, is included, regardless
of whether they are characterized or not.
- Proteins from the MetaCyc metabolic pathway database
are included if they are linked to a paper in PubMed and their full sequence is known.
- Proteins from the Transport Classification Database (TCDB)
are included if they have known substrate(s), have reference(s),
and are not described as uncharacterized or putative.
(Some of the references are not visible on the PaperBLAST web site.)
- Every protein from CharProtDB,
a database of experimentally characterized protein annotations, is included.
- Proteins from the CAZy database of carbohydrate-active enzymes
are included if they are associated with an Enzyme Classification number.
Even though CAZy does not provide links from individual protein sequences to papers,
these should all be experimentally-characterized proteins.
- Proteins from the REBASE database
of restriction enzymes are included if they have known specificity.
- Every protein with an evidence-based reannotation (based on mutant phenotypes)
in the Fitness Browser is included.
- Sequence-specific transcription factors (including sigma factors and DNA-binding response regulators)
with experimentally-determined DNA binding sites from the
PRODORIC database of gene regulation in prokaryotes.
- Putative transcription factors from RegPrecise
that have manually-curated predictions for their binding sites. These predictions are based on
conserved putative regulatory sites across genomes that contain similar transcription factors,
so PaperBLAST clusters the TFs at 70% identity and retains just one member of each cluster.
- Coding sequence (CDS) features from the
European Nucleotide Archive (ENA)
are included if the /experiment tag is set (implying that there is experimental evidence for the annotation),
the nucleotide entry links to paper(s) in PubMed,
and the nucleotide entry is from the STD data class
(implying that these are targeted annotated sequences, not from shotgun sequencing).
Also, to filter out genes whose transcription or translation was detected, but whose function
was not studied, nucleotide entries or papers with more than 25 such proteins are excluded.
Descriptions from ENA rely on the original submitter of the
sequence and cannot be updated by others, so they may be less reliable.
Except for GeneRIF and ENA,
the curated entries include a short curated
description of the protein's function.
For entries from BioLiP, the protein's function may not be known beyond binding to the ligand.
Many of these entries also link to articles in PubMed.
For more information see the
PaperBLAST paper (mSystems 2017)
or the code.
You can download PaperBLAST's database here.
Changes to PaperBLAST since the paper was written:
- November 2023: incorporated PRODORIC and RegPrecise. Many PRODORIC entries were not linked to a protein sequence (no UniProt identifier), so we added this information.
- February 2023: BioLiP changed their download format. PaperBLAST now includes their non-redundant subset. SitesBLAST and Sites on a Tree use a larger non-redundant subset that ensures that every ligand is represented within each cluster. This should ensure that every binding site is represented.
- June 2022: incorporated some coding sequences from ENA with the /experiment tag.
- March 2022: incorporated BioLiP.
- April 2020: incorporated TCDB.
- April 2019: EuropePMC now returns table entries in their search results. This has expanded PaperBLAST's database, but most of the new entries are of low relevance, and the resulting snippets are often just lists of locus tags with annotations.
- February 2018: the alignment page reports the conservation of the hit's functional sites (if available from from Swiss-Prot or UniProt)
- January 2018: incorporated BRENDA.
- December 2017: incorporated MetaCyc, CharProtDB, CAZy, REBASE, and the reannotations from the Fitness Browser.
- September 2017: EuropePMC no longer returns some table entries in their search results. This has shrunk PaperBLAST's database, but has also reduced the number of low-relevance hits.
Many of these changes are described in Interactive tools for functional annotation of bacterial genomes.
PaperBLAST cannot provide snippets for many of the papers that are
published in non-open-access journals. This limitation applies even if
the paper is marked as "free" on the publisher's web site and is
available in PubmedCentral or EuropePMC. If a journal that you publish
in is marked as "secret," please consider publishing elsewhere.
Many important articles are missing from PaperBLAST, either because
the article's full text is not in EuropePMC (as for many older
articles), or because the paper does not mention a protein identifier such as a locus tag, or because of PaperBLAST's heuristics. If you notice an
article that characterizes a protein's function but is missing from
PaperBLAST, please notify the curators at UniProt
or add an entry to GeneRIF.
Entries in either of these databases will eventually be incorporated
into PaperBLAST. Note that to add an entry to UniProt, you will need
to find the UniProt identifier for the protein. If the protein is not
already in UniProt, you can ask them to create an entry. To add an
entry to GeneRIF, you will need an NCBI Gene identifier, but
unfortunately many prokaryotic proteins in RefSeq do not have
corresponding Gene identifers.
References
PaperBLAST: Text-mining papers for information about homologs.
M. N. Price and A. P. Arkin (2017). mSystems, 10.1128/mSystems.00039-17.
Europe PMC in 2017.
M. Levchenko et al (2017). Nucleic Acids Research, 10.1093/nar/gkx1005.
Gene indexing: characterization and analysis of NLM's GeneRIFs.
J. A. Mitchell et al (2003). AMIA Annu Symp Proc 2003:460-464.
UniProt: the universal protein knowledgebase.
The UniProt Consortium (2016). Nucleic Acids Research, 10.1093/nar/gkw1099.
BRENDA in 2017: new perspectives and new tools in BRENDA.
S. Placzek et al (2017). Nucleic Acids Research, 10.1093/nar/gkw952.
The EcoCyc database: reflecting new knowledge about Escherichia coli K-12.
I. M. Keeseler et al (2016). Nucleic Acids Research, 10.1093/nar/gkw1003.
The MetaCyc database of metabolic pathways and enzymes.
R. Caspi et al (2018). Nucleic Acids Research, 10.1093/nar/gkx935.
CharProtDB: a database of experimentally characterized protein annotations.
R. Madupu et al (2012). Nucleic Acids Research, 10.1093/nar/gkr1133.
The carbohydrate-active enzymes database (CAZy) in 2013.
V. Lombard et al (2014). Nucleic Acids Research, 10.1093/nar/gkt1178.
The Transporter Classification Database (TCDB): recent advances
M. H. Saier, Jr. et al (2016). Nucleic Acids Research, 10.1093/nar/gkv1103.
REBASE - a database for DNA restriction and modification: enzymes, genes and genomes.
R. J. Roberts et al (2015). Nucleic Acids Research, 10.1093/nar/gku1046.
Deep annotation of protein function across diverse bacteria from mutant phenotypes.
M. N. Price et al (2016). bioRxiv, 10.1101/072470.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory