PaperBLAST
PaperBLAST Hits for reanno::pseudo1_N1B4:Pf1N1B4_1109 2-ketoglutaric semialdehyde dehydrogenase (EC 1.2.1.26) (Pseudomonas fluorescens FW300-N1B4) (481 a.a., VADAKRYDNY...)
Show query sequence
>reanno::pseudo1_N1B4:Pf1N1B4_1109 2-ketoglutaric semialdehyde dehydrogenase (EC 1.2.1.26) (Pseudomonas fluorescens FW300-N1B4)
VADAKRYDNYINGEWVSGADYSANINPSELTDTIGDYAKADLAQVHAAIDAARAAFPAWS
TSGIQARHDSLDKVGTEILARREELGTLLAREEGKTLPEAIGEVTRAGNIFKFFAGECLR
LSGDYLPSVRPGVNVEVTREALGVVGLITPWNFPIAIPAWKIAPALAYGNCVVLKPADLV
PGCAWALAEIISRAGFPAGVFNLVMGSGRVVGDALVQSPKVDGISFTGSVGVGRQIAVSC
VSRQAKVQLEMGGKNPQIILDDADLKQAVELSVQSAFYSTGQRCTASSRFIVTAGIHDKF
VEAMAERMKSIKVGHALKTGTDIGPVVSQAQLEQDLKYIDIGQSEGARLVSGGGLVACDT
EGYFLAPTLFADSTAAMRISREEIFGPVANIVRVADYEAALAMANDTEFGLSAGIATTSL
KYANHFKRHSQAGMVMVNLPTAGVDYHVPFGGRKGSSYGSREQGRYAQEFYTVVKTSYIG
S
Running BLASTp...
Found 250 similar proteins in the literature:
Pf1N1B4_1109 2-ketoglutaric semialdehyde dehydrogenase (EC 1.2.1.26) from Pseudomonas fluorescens FW300-N1B4
100% identity, 100% coverage
- mutant phenotype: Specifically important for: D-Galacturonic Acid monohydrate. ketoglutarate semialdehyde is an intermedate in the oxidation of galacturonate
PFLU0850 putative aldehyde dehydrogenase from Pseudomonas fluorescens SBW25
93% identity, 100% coverage
PS417_04200 2-ketoglutaric semialdehyde dehydrogenase (EC 1.2.1.26) from Pseudomonas simiae WCS417
PS417_04200 aldehyde dehydrogenase family protein from Pseudomonas simiae
93% identity, 100% coverage
- mutant phenotype: Specifically important for: D-Galacturonic Acid monohydrate. alpha-ketoglutarate semialdehyde is an intermediate in the oxidation of galacturonate
- Oxidative Pathways of Deoxyribose and Deoxyribonate Catabolism
Price, mSystems 2019 - “...in defined media with three carbon sources: d -glucose, deoxyribose, and deoxyribonate. The mutant of PS417_04200 (2-ketoglutaric semialdehyde dehydrogenase) is included as a control. Each curve is the median of six replicates. Each carbon source was provided at 10mM. The proposed pathway for deoxyribose catabolism in...”
Bphyt_5803 Aldehyde Dehydrogenase from Burkholderia phytofirmans PsJN
65% identity, 99% coverage
SAMCCGM7_Ch2624 aldehyde dehydrogenase family protein from Sinorhizobium americanum CCGM7
68% identity, 98% coverage
RL3613 putative aldehyde dehydrogenase from Rhizobium leguminosarum bv. viciae 3841
65% identity, 98% coverage
- Arabinose and protocatechuate catabolism genes are important for growth of Rhizobium leguminosarum biovar viciae in the pea rhizosphere
Garcia-Fraile, Plant and soil 2015 - “...X380 (H2K2C07-1C07) 3841 carrying mTn5 in RL4123 This study X382 (H3K3G11-1E05) 3841 carrying mTn5 in RL3613 This study X383 (H2K2B09-1B06) 3841 carrying mTn5 in RL0885 This study X384 (H2K2C07-1E04) 3841 carrying mTn5 in RL3906 This study X385(H2K2C07-1E03) 3841 carrying mTn5 in RL0079 This study RU4372 300...”
- “...This study A1402 300 carrying mTn5 in RL4123 This study A1404 300 carrying mTn5 in RL3613 This study A1405 300 carrying mTn5 in RL0885 This study A1406 300 carrying mTn5 in RL3906 This study E. coli S17-1 pir Donor strain for conjugation of STM plasmids (DeLorenzo...”
SM_b20891 Ketoglutarate semialdehyde dehydrogenase (EC 1.2.1.26) from Sinorhizobium meliloti 1021
66% identity, 98% coverage
- mutant phenotype: Specifically important for: L-Arabinose. The only dehydrogenase steps in the arabinose catabolism pathway are L-arabinose 1-dehydrogenase (which is SMc00588) and a-ketoglutarate semialdehyde dehydrogenase (EC 1.2.1.26). So, this is the semialdehyde dehydrogenase.
BAB1_0211 Aldehyde dehydrogenase from Brucella melitensis biovar Abortus 2308
BruAb1_0205 aldehyde dehydrogenase family protein from Brucella abortus biovar 1 str. 9-941
66% identity, 98% coverage
- Iron-dependent reconfiguration of the proteome underlies the intracellular lifestyle of Brucella abortus
Roset, Scientific reports 2017 - “...Mean ratio(I/C) SD Ratio Glycolysis/Gluconeogenesis GI:82699048 BAB1_0128 zinc-containing alcohol dehydrogenase C NO 1.35 0.10 GI:82699119 BAB1_0211 aldehyde dehydrogenase U NO 0.75 0.02 GI:91206675 BAB1_0316 pgi Glucose-6-phosphate isomerase C NO 0.60 0.06 GI:82699972 BAB1_1155 eno enolase U NO 1.60 0.40 GI:82698932 BAB1_1742 pgk Phosphoglycerate kinase C NO...”
- Brucella abortus choloylglycine hydrolase affects cell envelope composition and host cell internalization
Marchesini, PloS one 2011 - “...5.21 64.2 23.3 6.8 BAB1_1639 OM 126 Aldehyde dehydrogenase gi|17988023 4.40 5.99 31.4 51.1 2.8 BAB1_0211 C pH 4.75.9 10 25 kDa Omp 7 gi|3914203 5.15 8.58 55.4 23.2 2.1 BAB1_0722 OM 13 25 kDa Omp 4 gi|3914203 5.02 8.58 56.6 23.2 4.9 BAB1_0722 OM 19...”
- Microarray-based identification of differentially expressed genes in intracellular Brucella abortus within RAW264.7 cells
Tian, PloS one 2013 - “...in cellular processes; homoprotocatechuate 2,3-dioxygenase (Hpcd, BruAb2_1096) and the aldehyde dehydrogenase family of proteins (ALDH, BruAb1_0205) are involved in metabolic pathways; major facilitator family transporters (MFS, BruAb2_0692) and nickel transporter permease (NikC, BruAb2_0430) are involved in both cellular processes and metabolic pathways; and four hypothetical proteins,...”
- “...transporter Outer Membrane COG0477/GEPR 12.30 BruAb2_0126 flagellar basal body rod protein Outer Membrane COG1749/N 12.00 BruAb1_0205 aldehyde dehydrogenase family protein Outer Membrane COG1012/C 11.45 BruAb2_0430 nickel transporter permease Outer Membrane; Extracellular COG1173/EP 10.93 BruAb1_0475 hypothetical protein Unknown 10.53 BruAb2_0061 type IV secretion system protein VirB9 Outer...”
Ac3H11_612 2-ketoglutaric semialdehyde dehydrogenase (EC 1.2.1.26) from Acidovorax sp. GW101-3H11
62% identity, 98% coverage
- mutant phenotype: Specifically important for utilizing L-Arabinose. Automated validation from mutant phenotype: the predicted function (25-DIOXOVALERATE-DEHYDROGENASE-RXN) was linked to the condition via a MetaCyc pathway. This annotation was also checked manually.
PP2694 aldehyde dehydrogenase family protein from Pseudomonas putida KT2440
PP_2694 aldehyde dehydrogenase family protein from Pseudomonas putida KT2440
58% identity, 99% coverage
- Mechanisms of resistance to chloramphenicol in Pseudomonas putida KT2440
Fernández, Antimicrobial agents and chemotherapy 2012 - “...PP2677 (M) PP2678 PP2679 PP2680 PP2681 PP2682 PP2683 PP2688 PP2694 (M) PP2695 (M) PP2723 (M) PP2821 PP2936 PP2943 PP3138 (M) PP3155 (M) PP3214 PP3297 PP3316...”
- Genomic analysis reveals the major driving forces of bacterial life in the rhizosphere
Matilla, Genome biology 2007 - “...gamma subunit 4.8 7.9 5.8 6 PP1403 - bglX -periplasmic beta-glucosidase 2.5 2.9 2.5 2.6 PP2694 - aldehyde dehydrogenase family protein 9 8.3 LS 10.2 PP2847 - ureJ -urease accessory protein UreJ 22.9 29.6 21.9 24.6 PP3281 - phenylacetic acid degradation protein PaaI putative 6.2 8.1...”
- Computational analysis into the potential of azo dyes as a feedstock for actinorhodin biosynthesis in Pseudomonas putida
Nayyara, PloS one 2024 - “...MALS, FDH, SUCD4, ALDD2y, ALDD2x, SUCDi, GLYOX, NACODA, PGL PP_0356, PP_2183, PP_0489, PP_4203, PP_2589, PP_0545, PP_2694, PP_4190, PP_2492, PP_4144, PP_5186, PP_1023 2 1 0 MALS, ALDD2y, MTHFC, ALDD2x, SUCDi, GLYOX, NACODA, ACACt2pp, RPE PP_0356, PP_2492, PP_2265, PP_1945, PP_2589, PP_0545, PP_2694, PP_4190, PP_4144, PP_5186, PP_0415, PP_3124 4...”
- “...PP_4186, PP_4666, PP_4947, PP_2492, PP_4144, PP_2351, PP_2339, PP_2112, PP_2082, PP_1023, PP_0612, PP_3124, PP_0654, PP_2589, PP_0545, PP_2694, PP_1620, PP_0327, PP_1367, PP_1943, PP_1664, PP_5347, PP_4116, PP_1031, PP_4947 5 1 5 ALDD2y, FTHFD, ALDD2x, MDH, MICITDr, GLYOX, ACACT11, MALS, PGL, ACONTa, NACODA PP_2492, PP_0327, PP_1367, PP_1943, PP_2589, PP_0545, PP_2694,...”
xylA / A0A0H3C801 2,5-dioxovalerate dehydrogenase (EC 1.2.1.26) from Caulobacter vibrioides (strain NA1000 / CB15N) (see 6 papers)
CC0822, CC_0822 aldehyde dehydrogenase from Caulobacter crescentus CB15
59% identity, 98% coverage
- Carbohydrate metabolism in Archaea: current insights into unusual enzymes and pathways and their regulation
Bräsen, Microbiology and molecular biology reviews : MMBR 2014 - “...(283- 285). In Cau. crescentus, the KGSADH-encoding gene (CC_0822) is also located in the xylose gene cluster, as de- Microbiology and Molecular Biology Reviews...”
- D-xylose degradation pathway in the halophilic archaeon Haloferax volcanii
Johnsen, The Journal of biological chemistry 2009 - “...genes of H. volcanii and H. crescentus the ortholog CC_0822, which is 45% identical to marismortui are found in two and three different genomic KGSADH form H....”
- Genetic analysis of a novel pathway for D-xylose metabolism in Caulobacter crescentus
Stephens, Journal of bacteriology 2007 - “...of the xyl operon are hereafter designated xylA (CC0822), xylB (CC0821), xylC (CC0820), and xylD (CC0819). Because transposon insertions in upstream genes of...”
- “...isolates Annotation Proposed function xylX (CC0823) xylA (CC0822) 2 2 Conserved hypothetical protein Aldehyde dehydrogenase xylB (CC0821) 1 xylC (CC0820)...”
- Transcriptional profiling of Caulobacter crescentus during growth on complex and minimal media
Hottes, Journal of bacteriology 2004 - “...putativea,b,c CC0819, dehydratase, IlvD/Edd familyd CC0822, aldehyde dehydrogenase, aldAd CC0945, oxidoreductase, glucose-methanolcholine family CC1534,...”
- “...M2G) for CC0820 to a high of 11.6-fold for CC0822. (No expression data were obtained for CC0821.) A chromosomal Tn5-lacZ insertion previously isolated in the...”
P42329 Aldehyde dehydrogenase, thermostable from Geobacillus stearothermophilus
44% identity, 98% coverage
BLi00285 YcbD from Bacillus licheniformis DSM 13
44% identity, 98% coverage
HWX41_RS19325 aldehyde dehydrogenase family protein from Bacillus paramycoides
43% identity, 99% coverage
- Genomic Analysis of Endophytic Bacillus cereus T4S and Its Plant Growth-Promoting Traits
Adeleke, Plants (Basel, Switzerland) 2021 - “...HWX41_RS06485 dha aldehyde dehydrogenase HWX41_RS25615 dha acetaldehyde dehydrogenase (acetylating) HWX41_RS13995 dha aldehyde dehydrogenase family protein HWX41_RS19325 dha aldehyde dehydrogenase family protein HWX41_RS06850 dha aldehyde dehydrogenase family protein HWX41_RS10480 dha aldehyde dehydrogenase family protein HWX41_RS13000 dha aldehyde dehydrogenase family protein HWX41_RS17225 dha aldehyde dehydrogenase family protein HWX41_RS17590...”
alr3771 aldehyde dehydrogenase from Nostoc sp. PCC 7120
41% identity, 95% coverage
- Nitrogen-regulated antisense transcription in the adaptation to nitrogen deficiency in Nostoc sp. PCC 7120
Brenes-Álvarez, PNAS nexus 2023 - “...TU01300 ggt TU03408 6.23 4.75 alr4984 E-DIF TU03409 susA TU02503 6.18 3.76 all3772 E-DIF TU02502 alr3771 TU00203 5.42 7.24 hesF L-DIF TU00204 prfB to all0268 TU00037 5.27 3.50 all0059 TU00036 alr0056alr0058 TU02896 5.15 3.59 nrrA NtcA TU02895 alr4310 TU01911 4.82 5.80 all2965 L-DIF TU01912 alr2966alr2967 TU01656...”
- Bioinformatic evaluation of L-arginine catabolic pathways in 24 cyanobacteria and transcriptional analysis of genes encoding enzymes of L-arginine catabolism in the cyanobacterium Synechocystis sp. PCC 6803
Schriek, BMC genomics 2007 - “...Gll2207, Gll1504, Glr3848, Gll2805 Nostoc sp. PCC 7120 All3401, All4887 Alr2310 n.d Alr2001 n.d Alr2826, Alr3771, All3556, All5022 Nostoc punctiforme PCC 73102 Npun02000556, Npun02000612 Npun02002114 n.d Npun02002053 n.d Npun02003427, Npun02002895, Npun02002692, Npun02003702 Anabaena variabilis ATCC 29413 Ava_2157, Ava_3423 Ava_0127 n.d Ava_5061 n.d Ava_1107, Ava_1554, Ava_3534, Ava_2258...”
- “...Glr3849, Gll2223 Glr2755, Glr3848, Gll1504, Gll2805 Nostoc sp. PCC 7120 Alr2310 Alr2398, Alr1080, All0396 Alr0540, Alr3771, All3556, All5022 Nostoc punctiforme PCC 73102 Npun02002114 Npun02005728, Npun02001164, Npun02001509 Npun02003702, Npun02006572, Npun02002895, Npun02002692 Anabaena variabilis ATCC 29413 Ava_0127 Ava_0214, Ava_3730, Ava_2839 Ava_2942, Ava_1554, Ava_3534, Ava_2258 N.d. = not detected....”
KGSDH_BACSU / P42236 Alpha-ketoglutaric semialdehyde dehydrogenase; alphaKGSA dehydrogenase; 2,5-dioxovalerate dehydrogenase; EC 1.2.1.26 from Bacillus subtilis (strain 168) (see 2 papers)
44% identity, 98% coverage
- function: Catalyzes the NAD(P)(+)-dependent oxidation of alpha- ketoglutaric semialdehyde (alphaKGSA) to alpha-ketoglutarate. Prefers NADP(+) to NAD(+) as a cosubstrate. In vitro, can also use various aldehydes.
catalytic activity: 2,5-dioxopentanoate + H2O + NADP(+) = 2-oxoglutarate + 2 H(+) + NADPH (RHEA:11296)
catalytic activity: 2,5-dioxopentanoate + H2O + NAD(+) = 2-oxoglutarate + 2 H(+) + NADH (RHEA:47152)
subunit: Homotetramer.
disruption phenotype: No effect on vanillin degradation.
Ava_1554 Aldehyde dehydrogenase from Anabaena variabilis ATCC 29413
40% identity, 95% coverage
- Bioinformatic evaluation of L-arginine catabolic pathways in 24 cyanobacteria and transcriptional analysis of genes encoding enzymes of L-arginine catabolism in the cyanobacterium Synechocystis sp. PCC 6803
Schriek, BMC genomics 2007 - “...Npun02003427, Npun02002895, Npun02002692, Npun02003702 Anabaena variabilis ATCC 29413 Ava_2157, Ava_3423 Ava_0127 n.d Ava_5061 n.d Ava_1107, Ava_1554, Ava_3534, Ava_2258 N.d. = not detected. Table 6 Database entries of genes from 24 cyanobacterial genomes encoding putative arginases (B1), L-ornithine transaminases (C2), and 1 pyrroline-5-carboxylate dehydrogenases (C3) of the...”
- “...Npun02001164, Npun02001509 Npun02003702, Npun02006572, Npun02002895, Npun02002692 Anabaena variabilis ATCC 29413 Ava_0127 Ava_0214, Ava_3730, Ava_2839 Ava_2942, Ava_1554, Ava_3534, Ava_2258 N.d. = not detected. Table 7 Database entries of genes from 24 cyanobacterial genomes encoding putative L-arginine amidinotransferases (C1), L-ornithine transaminases (C2), and 1 pyrroline-5-carboxylate dehydrogenases (C3) of...”
xacF / D4GP41 α-ketoglutarate semialdehyde dehydrogenase subunit (EC 1.2.1.26) from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (see paper)
KGSDH_HALVD / D4GP41 Alpha-ketoglutarate semialdehyde dehydrogenase; KGSADH; EC 1.2.1.26 from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii) (see 2 papers)
HVO_B0039 alpha-ketoglutarate semialdehyde dehydrogenase from Haloferax volcanii DS2
43% identity, 98% coverage
- function: Alpha-ketoglutarate semialdehyde dehydrogenase involved in the degradation of D-xylose, a major component of hemicelluloses such as xylan. Catalyzes the fifth reaction in the xylose utilization pathway through dehydratation of alpha-ketoglutarate semialdehyde (2,5- dioxopentanoate) into alpha-ketoglutarate.
catalytic activity: 2,5-dioxopentanoate + H2O + NADP(+) = 2-oxoglutarate + 2 H(+) + NADPH (RHEA:11296)
subunit: Homotetramer.
disruption phenotype: Impairs growth on D-xylose as sole energy and carbon substrate. - Biochemical routes for uptake and conversion of xylose by microorganisms
Zhao, Biotechnology for biofuels 2020 - “...xylose dehydrogenase (HVO_B0028), xylonolactonase (HVO_B0030), xylonate dehydratase (HVO_B0038A), 2-keto-3-deoxy-xylonate dehydratase (HVO_B0027), and -ketoglutarate semialdehyde dehydrogenase (HVO_B0039) [ 55 ]. The related genes in H. volcanii are clustered and transcriptionally regulated by a putative IclR-like regulator HVO_B0040 (designated XacR) [ 56 ]. XacR is an activator for...”
- Metabolic reconstruction and experimental verification of glucose utilization in Desulfurococcus amylolyticus DSM 16532
Reischl, Folia microbiologica 2018 - “...could be detected. Furthermore, no H. volcanii homologs for arabinose degradation (e.g. HVO_B0038A, HVO_B0027, or HVO_B0039 (Johnsen et al. 2013 ) could be identified in the genome of D. amylolyticus . Concerning utilization of disaccharides by D. amylolyticus , sucrose could be split into D-fructose and...”
- Carbohydrate metabolism in Archaea: current insights into unusual enzymes and pathways and their regulation
Bräsen, Microbiology and molecular biology reviews : MMBR 2014 - “...genes, HVO_B0027, HVO_B0028, HVO_B0038A, and HVO_B0039, encoding 2-keto-3-deoxyxylonate dehydratase (KDXD), xylose dehydrogenase (XDH), xylonate dehydratase...”
- “...cells of Hfx. volcanii, and the encoding gene, HVO_B0039, was identified after N-terminal amino acid sequencing (287). Hfx. volcanii KGSADH was characterized as...”
- L-Arabinose degradation pathway in the haloarchaeon Haloferax volcanii involves a novel type of L-arabinose dehydrogenase
Johnsen, Extremophiles : life under extreme conditions 2013 (PubMed)- “...and deletion mutants as HVO_B0038A, HVO_B0027 and HVO_B0039 recently reported to be involved in D-xylonate conversion to a-ketoglutarate in H. volcanii...”
- “...frames HVO_B0027, HVO_B0028, HVO_B0038A and HVO_B0039 encode 2-keto-3-deoxy-D-xylonate dehydratase (KDXD), xylose dehydrogenase (XDH), xylonate dehydratase...”
- D-xylose degradation pathway in the halophilic archaeon Haloferax volcanii
Johnsen, The Journal of biological chemistry 2009 - “...dehydratase (HVO_B0027), and -ketoglutarate semialdehyde dehydrogenase (HVO_B0039). The functional involvement of these enzymes in xylose degradation was proven...”
- “...deletion mutants (HVO_B0027, HVO_B0028, HVO_B0029, HVO_B0038A, and HVO_B0039), a complex medium (8) containing 1% casamino acids was used. For pop-out...”
MSMEG_6687 aldehyde dehydrogenase, thermostable from Mycobacterium smegmatis str. MC2 155
44% identity, 97% coverage
- Distinct Responses of Mycobacterium smegmatis to Exposure to Low and High Levels of Hydrogen Peroxide
Li, PloS one 2015 - “...-4.0478653 2.97E-105 4.33E-104 -2.1612025 4.92E-60 2.38E-59 msmeg_6616 S-(hydroxymethyl)glutathione dehydrogenase -2.956082 0.00E+00 0.00E+00 -1.1422205 1.36E-159 1.45E-158 msmeg_6687 aldehyde dehydrogenase, thermostable -3.706221 1.64E-29 1.03E-28 -1.5049935 9.36E-12 1.94E-11 msmeg_6834 alcohol dehydrogenase -2.7848309 2.21E-05 5.51E-05 0.08733237 0.840712 0.85579383 fadA acetyl-CoA acetyltransferase -2.7273404 0.00E+00 0.00E+00 0.33348045 5.36E-35 1.86E-34 fadB putative 3-hydroxyacyl-CoA...”
glr3848 aldehyde dehydrogenase from Gloeobacter violaceus PCC 7421
40% identity, 95% coverage
- Bioinformatic evaluation of L-arginine catabolic pathways in 24 cyanobacteria and transcriptional analysis of genes encoding enzymes of L-arginine catabolism in the cyanobacterium Synechocystis sp. PCC 6803
Schriek, BMC genomics 2007 - “...Sll1495, Slr0370 Gloeobacter violaceus PCC 7421 Gll4070, Gll3478 n.d Glr1681 Glr1682, Glr2043 n.d Gll2207, Gll1504, Glr3848, Gll2805 Nostoc sp. PCC 7120 All3401, All4887 Alr2310 n.d Alr2001 n.d Alr2826, Alr3771, All3556, All5022 Nostoc punctiforme PCC 73102 Npun02000556, Npun02000612 Npun02002114 n.d Npun02002053 n.d Npun02003427, Npun02002895, Npun02002692, Npun02003702 Anabaena...”
- “...Sll1077, Sll0228 Slr1022 Sll1561, Slr0370, Slr0091 Gloeobacter violaceus PCC 7421 n.d. Glr0547, Glr3849, Gll2223 Glr2755, Glr3848, Gll1504, Gll2805 Nostoc sp. PCC 7120 Alr2310 Alr2398, Alr1080, All0396 Alr0540, Alr3771, All3556, All5022 Nostoc punctiforme PCC 73102 Npun02002114 Npun02005728, Npun02001164, Npun02001509 Npun02003702, Npun02006572, Npun02002895, Npun02002692 Anabaena variabilis ATCC 29413...”
dopDH / Q97UA1 2,5-dioxopentanoate dehydrogenase subunit (EC 1.2.1.26) from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (see paper)
KGSDH_SACS2 / Q97UA1 2,5-dioxopentanoate dehydrogenase; DopDH; Aldehyde dehydrogenase T; Alpha-ketoglutaric semialdehyde dehydrogenase AldhT; EC 1.2.1.26 from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see paper)
Q97UA1 lactaldehyde dehydrogenase (EC 1.2.1.22); 2,5-dioxovalerate dehydrogenase (EC 1.2.1.26) from Saccharolobus solfataricus (see 3 papers)
SSO3117 Aldehyde dehydrogenase (aldhT) from Sulfolobus solfataricus P2
SSO3117 2,5-dioxopentanoate dehydrogenase from Saccharolobus solfataricus P2
41% identity, 98% coverage
- function: 2,5-dioxopentanoate dehydrogenase involved in the degradation of pentoses such as D-arabinose or D-xylose, a major component of hemicelluloses such as xylan. Catalyzes the fifth reaction in the pentose utilization pathway through dehydratation of 2,5- dioxopentanoate into 2-oxoglutarate. Shows also dehydrogenase activity toward glycolaldehyde and DL-glyceraldehyde.
catalytic activity: 2,5-dioxopentanoate + H2O + NADP(+) = 2-oxoglutarate + 2 H(+) + NADPH (RHEA:11296)
subunit: Homotetramer. - Utilization of Phenol as Carbon Source by the Thermoacidophilic Archaeon Saccharolobus solfataricus P2 Is Limited by Oxygen Supply and the Cellular Stress Response
Wolf, Frontiers in microbiology 2020 - “...branch. The genome encodes for five members of the aldehyde dehydrogenase superfamily: Two of them, Sso3117 and Sso3194, have been extensively studied and proven to be involved in different sugar degradation pathways ( Brouns et al., 2006 ; Ettema et al., 2008 ). The remaining candidates...”
- Sulfolobus acidocaldarius Transports Pentoses via a Carbohydrate Uptake Transporter 2 (CUT2)-Type ABC Transporter and Metabolizes Them through the Aldolase-Independent Weimberg Pathway
Wagner, Applied and environmental microbiology 2018 - “...Saci_1938 and Saci_1939 are close homologues of KGSADH (SSO3117; 84% sequence identity) and KDXD (also known as KDAD) (SSO3118; 78% sequence identity), involved...”
- “...to 2-oxoglutarate in addition to the canonical KGSADH (SSO3117) (48). Therefore, it is likely that these aldehyde dehydrogenase homologues account for the...”
- Metabolic reconstruction and experimental verification of glucose utilization in Desulfurococcus amylolyticus DSM 16532
Reischl, Folia microbiologica 2018 - “...al. 2006 ) and genes for arabinose degradation found in S. solfataricus , e.g., SSO3124, SSO3117 and SSO3118 (Peng et al. 2011 ) or SSO3107, SSO1303 (Brouns et al. 2006 ), could not be detected in the genome of D. amylolyticus . Only a homolog of...”
- Carbohydrate metabolism in Archaea: current insights into unusual enzymes and pathways and their regulation
Bräsen, Microbiology and molecular biology reviews : MMBR 2014 - “...to the characterized KGSADH enzyme from Sul. solfataricus (SSO3117) (283- 285). In Cau. crescentus, the KGSADH-encoding gene (CC_0822) is also located in the...”
- “...has not yet been shown. Also, -KGSADH (DOPDH; SSO3117) has been reported to utilize glycolaldehyde as the substrate (283), and the NADP-dependent gylcolaldehyde...”
- Metabolism of pentose sugars in the hyperthermophilic archaea Sulfolobus solfataricus and Sulfolobus acidocaldarius
Nunn, The Journal of biological chemistry 2010 - “...(2-Oxoglutarate Semialdehyde) Dehydrogenase--The 2,5-dioxopentanoate dehydrogenase gene (SSO3117) annotated in the genome of S. solfataricus was cloned into...”
- “...al. (8) reported that S. solfataricus gene SSO3117 encodes an aldehyde dehydrogenase that, when recombinantly expressed, possessed catalytic activity with...”
- D-xylose degradation pathway in the halophilic archaeon Haloferax volcanii
Johnsen, The Journal of biological chemistry 2009 - “...in H. volcanii and C. crescentus. to characterized KGSADH (SSO3117, 44%) from S. solfatari- Haloarcula and Halorubrum contain homologs of the cus and to KGSADH...”
Hlac_2240 Aldehyde Dehydrogenase from Halorubrum lacusprofundi ATCC 49239
42% identity, 98% coverage
Saci_1938 aldehyde dehydrogenase from Sulfolobus acidocaldarius DSM 639
41% identity, 97% coverage
- Identification of XylR, the Activator of Arabinose/Xylose Inducible Regulon in Sulfolobus acidocaldarius and Its Application for Homologous Protein Expression
van, Frontiers in microbiology 2020 - “...D-xylonate/L-arabinoate dehydratase (D-KDXD/L-KDAD, Saci_1039), the 2-keto-deoxy-D-xylonate/L-arabinoate dehydratase (D-KDXD/L-KDAD, Saci_1939), and the -ketoglutarate semialdehyde dehydrogenase (-KGSADH, Saci_1938) degrade the metabolites to -ketoglutarate, a central intermediate of the citric acid cycle. Our studies demonstrated that S. acidocaldarius strain MW001 utilizes only the Weimberg pathway and not the aldolase-dependent...”
- “...system were integrated. PCR products of 100 bp base pairs upstream of saci_2122 (pSVAaraFX-) or saci_1938 (pSVAxylFX-) were generated to create the pentose inducible expression plasmids, and a PCR product of 150 bp base pairs upstream of saci_1165 (pSVAmalFX-) for the maltose/dextrin inducible promoter. With an...”
- Sulfolobus acidocaldarius Transports Pentoses via a Carbohydrate Uptake Transporter 2 (CUT2)-Type ABC Transporter and Metabolizes Them through the Aldolase-Independent Weimberg Pathway
Wagner, Applied and environmental microbiology 2018 - “...D-xylose medium. The -ketoglutarate semialdehyde dehydrogenase (KGSADH; Saci_1938) seemed not to be essential for growth on pentoses. However, the deletion...”
- “...observed for the four genes saci_2122, saci_2121, saci_1938, and saci_1939. Bioinformatic analysis of saci_2121 and saci_2122 using BLASTP 2.3.0 (34) indicated...”
- Protein phosphorylation and its role in archaeal signal transduction
Esser, FEMS microbiology reviews 2016 (no snippet) - Archaeal signal transduction: impact of protein phosphatase deletions on cell size, motility, and energy metabolism in Sulfolobus acidocaldarius
Reimann, Molecular & cellular proteomics : MCP 2013 - “...purchased from Promega (Madison, WI). The p-peptide TEVGKRI(pY)RLVGDKN was synthesized according to the p-peptide of Saci_1938 determined in the phosphoproteome analysis and purchased from PROTEINMODS (Madison, WI). For the characterization of Saci_PTP the p-peptides NIDAIRA(pS)LNIMSR and ETTYERW(pT)TITQRER derived from the respective p-peptides of Saci_1346 and Saci_1857,...”
rrnAC3036 aldehyde dehydrogenase from Haloarcula marismortui ATCC 43049
41% identity, 99% coverage
Saci_1700 aldehyde dehydrogenase from Sulfolobus acidocaldarius DSM 639
41% identity, 94% coverage
BpOF4_21524 aldehyde dehydrogenase from Bacillus pseudofirmus OF4
39% identity, 98% coverage
SLG_31150 NAD-dependent succinate-semialdehyde dehydrogenase from Sphingobium sp. SYK-6
39% identity, 95% coverage
- Bacterial Catabolism of β-Hydroxypropiovanillone and β-Hydroxypropiosyringone Produced in the Reductive Cleavage of Arylglycerol-β-Aryl Ether in Lignin
Higuchi, Applied and environmental microbiology 2018 - “...SLG_20400, 371 SLG_27910 (bzaA), SLG_27920 (bzaB), SLG_28150, SLG_31150, SLG_38120] were 372 used instead of the control vector, HPV was converted into...”
- “...SLG_07270, SLG_12800, 374 SLG_18210, SLG_20400, bzaA, bzaB, and SLG_31150, larger amounts of VAA 375 accumulated (Fig. 5A). We, therefore, measured the VAA...”
- A bacterial aromatic aldehyde dehydrogenase critical for the efficient catabolism of syringaldehyde
Kamimura, Scientific reports 2017 - “...amplified for 18 ALDH genes ( Fig. 2 ). In contrast, no amplification products of SLG_31150, SLG_34940, SLG_38120, SLG_11410, and SLG_32240 were obtained from RNA isolated from cells grown in either culture condition ( Fig. 2 ). To investigate the ability of putative ALDH gene products...”
Trad_2228 aldehyde dehydrogenase family protein from Truepera radiovictrix DSM 17093
38% identity, 90% coverage
WP_013178702 aldehyde dehydrogenase family protein from Truepera radiovictrix
38% identity, 89% coverage
RGM3321_11565 aldehyde dehydrogenase from Pseudomonas sp. RGM 3321
39% identity, 96% coverage
Dret_0129 betaine aldehyde dehydrogenase from Desulfohalobium retbaense DSM 5692
38% identity, 95% coverage
- Complete genome sequence of Desulfohalobium retbaense type strain (HR(100))
Spring, Standards in genomic sciences 2010 - “...be oxidized to glycine betaine by the enzymes choline dehydrogenase (Dret_0130) and betaine aldehyde dehydrogenase (Dret_0129). The sensitivity of the obligately anaerobic species D. retbaense to oxygen exposure has not been analyzed in detail, but it can be assumed that it is quite moderate as in...”
HWX41_RS17225 aldehyde dehydrogenase family protein from Bacillus paramycoides
38% identity, 94% coverage
- Genomic Analysis of Endophytic Bacillus cereus T4S and Its Plant Growth-Promoting Traits
Adeleke, Plants (Basel, Switzerland) 2021 - “...dehydrogenase family protein HWX41_RS10480 dha aldehyde dehydrogenase family protein HWX41_RS13000 dha aldehyde dehydrogenase family protein HWX41_RS17225 dha aldehyde dehydrogenase family protein HWX41_RS17590 dha aldehyde dehydrogenase family protein HWX41_RS14005 CK biosynthesis and transformation mia A tRNA (adenosine(37)-N6)-dimethylallyltransferase Mia A HWX41_RS05835 Ammonia production nad E ammonia-dependent NAD(+) synthetase...”
GK2772 NAD-dependent aldehyde dehydrogenase from Geobacillus kaustophilus HTA426
41% identity, 95% coverage
- A novel alkane monooxygenase evolved from a broken piece of ribonucleotide reductase in Geobacillus kaustophilus HTA426 isolated from Mariana Trench
Nithimethachoke, Extremophiles : life under extreme conditions 2024 - “...respectively. This maverick gene gk2771 forms a cluster with the genes encoding aldehyde dehydrogenase ( gk2772 , GK2772) and alcohol dehydrogenase ( gk2774 , GK2774), which are essential for alkane metabolism (Ji et al. 2013 ). GK2771 location strongly implies its involvement in alkane metabolism rather...”
- “...metabolism including beta-oxidation (Fig. 3 ). These are GK2771, putative alkane monooxygenase; GK2774, alcohol dehydrogenase; GK2772, aldehyde dehydrogenase; GK2782, long-chain fatty acid CoA ligase; GK2780/GK2781 (GK3006), GK2779, enoyl-CoA hydratase; acyl-CoA dehydrogenase; GK2778, 3-oxoacyl carrier protein reductase; enoyl-CoA hydratase; (GK3008), 3-hydroxyacyl-CoA dehydrogenase; and GK2777 (GK3007), thiolase/acetyl-CoA acetyltransferase....”
Q5KEX3 Aldehyde dehydrogenase (Alddh), putative from Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)
CNF03900 aldehyde dehydrogenase (alddh) from Cryptococcus neoformans var. neoformans JEC21
39% identity, 93% coverage
- Identifying Potential Molecular Targets in Fungi Based on (Dis)Similarities in Binding Site Architecture with Proteins of the Human Pharmacolome
Bedoya-Cardona, Molecules (Basel, Switzerland) 2023 - “...73 G8BKE8 71 Q5KEJ1 73 ALDH class 2 P05091 F0UNE9 75 Q4WM26 79 Q6FPK0 74 Q5KEX3 73 A0A0D2XAL2 74 CPSase 1 P31327 F0UNF7 75 Tubulin beta-3 chain Q13509 F0UQK5 74 Q4WA70 93 A0A1D8PC97 96 G8B7W7 96 Q5K876 89 A0A0C4DHQ2 93 MEK2 P36507 F0UAN5 74 Q4WWH7 76...”
- Role of clathrin-mediated endocytosis in the use of heme and hemoglobin by the fungal pathogen Cryptococcus neoformans
Bairwa, Cellular microbiology 2019 - “...encoding a calmodulin-dependent protein kinase-I; 2) Functions for gluconeogenesis (e.g., CNA00280 encoding an alcohol dehydrogenase, CNF03900 encoding an aldehyde dehydrogenase, CND03740 encoding aldo-keto reductase) and; 3) DNA synthesis and mismatch repair (e.g., FEN1 , MSH2 , CNA03100 , CNG03940 , CNK01700 and CND04530 ) ( Fig....”
- Brain inositol is a novel stimulator for promoting Cryptococcus penetration of the blood-brain barrier
Liu, PLoS pathogens 2013 - “...Metabolism CNH03280 CNAG_05303 Isocitrate lyase 5.27 CNA00470 CNAG_00057 Fructose-1,6-bisphosphatase 5.02 CNA04370 CNAG_00457 Glutamine synthetase 4.41 CNF03900 CNAG_06628 Aldehyde dehydrogenase 4.31 CNC02480 CNAG_01745 sn-Glycerol-3-phosphate dehydrogenase 3.52 CNF04450 CNAG_07660 Pyruvate dehydrogenase 3.51 CNA01050 CNAG_00115 Sorbitol dehydrogenase 3.33 CNJ00950 CNAG_04659 Pyruvate decarboxylase 3.23 CNG00600 CNAG_07745 Mannitol-1-phosphate dehydrogenase 3.00 CNC06440...”
- Importance of mitochondria in survival of Cryptococcus neoformans under low oxygen conditions and tolerance to cobalt chloride
Ingavale, PLoS pathogens 2008 - “...(Sdh4 subunit) CNJ00140 3.12 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit CND02060 1.57 Succinate-semialdehyde dehydrogenase I, GabD CNF03900 1.32 Succinate-semialdehyde dehydrogenase I, Alddh CNA05580 1.27 Complex I protein (LYR family) Complex III CNF00630 1.40 Electron transporter, cytochrome c 1 CNH02740 1.17 ubiquinol-cytochrome C reductase complex (Qcr9 subunit) CNG00860...”
- Metabolic adaptation in Cryptococcus neoformans during early murine pulmonary infection
Hu, Molecular microbiology 2008 - “...gene name (if known) Glyoxylate cycle and acetate/ethanol/pyruvate metabolism CAGCAGTGTA 3 0 144 46 7 CNF03900 XM_571348 aldehyde dehydrogenase CGCGAGGGCA 1 9 80 40 0 CNA07740 XM_567122 acetyl-CoA synthase, ACS1 GCCCAGCAGG 0 1 62 25 0 CNH02910 XM_572462 malate synthase, MLS1 CATCACTCTT 13 2 39 48...”
Q9FAB1 long-chain-aldehyde dehydrogenase (EC 1.2.1.48) from Geobacillus thermoleovorans (see paper)
40% identity, 96% coverage
SCHCODRAFT_65657 aldehyde dehydrogenase from Schizophyllum commune H4-8
41% identity, 94% coverage
3jz4A / P25526 Crystal structure of e. Coli NADP dependent enzyme (see paper)
38% identity, 99% coverage
- Ligand: nadp nicotinamide-adenine-dinucleotide phosphate (3jz4A)
Gmet_2131 Aldehyde dehydrogenase from Geobacter metallireducens GS-15
39% identity, 98% coverage
Pc18g02760 uncharacterized protein from Penicillium rubens
39% identity, 88% coverage
- Diamine Fungal Inducers of Secondary Metabolism: 1,3-Diaminopropane and Spermidine Trigger Enzymes Involved in β-Alanine and Pantothenic Acid Biosynthesis, Precursors of Phosphopantetheine in the Activation of Multidomain Enzymes
Martín, Antibiotics (Basel, Switzerland) 2024 - “...these isoforms revealed that all of them correspond to protein KAJ6152794 encoded by the gene Pc18g02760 in the genome of P chrysogenum Wis 54-1255 [ 61 ]. This gene contains four introns and encodes a protein of 502 amino acids. The same P. chrysogenum protein with...”
- Resolving phenylalanine metabolism sheds light on natural synthesis of penicillin G in Penicillium chrysogenum
Veiga, Eukaryotic cell 2012 - “...in P. chrysogenum (Pc14g01080, Pc21g22810, Pc22g24860, Pc18g02760, Pc14g01040, Pc22g17230, Pc20g11160, Pc22g19300, and Pc06g00180), only three were expressed in...”
- “...participating in this pathway. The two remaining genes, Pc18g02760 and Pc06g00180, exhibited a slight upregulation on phenylalanine with a fold change of 1.4...”
Smp_022960 putative aldehyde dehydrogenase from Schistosoma mansoni
40% identity, 91% coverage
- The genome of the blood fluke Schistosoma mansoni
Berriman, Nature 2009 - “...Smp_016780 1 tubulin alpha chain, putative Vinblastine A , Colchicine A , Vincristine A , Smp_022960 aldehyde dehydrogenase, putative Disulfiram B Smp_026560 calmodulin, putative Bepridil C Smp_030730 1 tubulin beta chain, putative Colchicine A , Vinblastine A , Vincristine A , Albendazole B , Mebendazole B...”
Sca_1625 putative aldehyde dehydrogenase family protein from Staphylococcus carnosus subsp. carnosus TM300
B9DMD5 aldehyde dehydrogenase (NAD(+)) from Staphylococcus carnosus (strain TM300)
40% identity, 97% coverage
- S-bacillithiolation protects conserved and essential proteins against hypochlorite stress in firmicutes bacteria
Chi, Antioxidants & redox signaling 2013 - “...dehydrogenase ThiM Hydroxyethylthiazole kinase (thiamine biosynthesis) Sca_1625 Putative aldehyde dehydrogenase family protein (similar to GbsA betaine aldehyde...”
- “...(S8Z), DnaK (S9A), GrpE (S9B), Ldh (S9C), ThiM (S9D), Sca_1625 (S9E), YtpR (S9F), Dtd (S9G), SceB (S9H), Sca_1381 (S9I), TypA (S9J), Sca_1554 (S9K), and Adk...”
- S-bacillithiolation protects conserved and essential proteins against hypochlorite stress in firmicutes bacteria
Chi, Antioxidants & redox signaling 2013 - “...(Continued) 1286 ThiG B4AF80 MetE GuaB B9DMD5 B9DNK0 B9DNK1 B9DN51 Q9RGS6 B9DJN8 B9DNY0 Phospho-2-dehydro-3deoxyheptonate aldolase/ chorismate mutase...”
GabD / b2661 succinate-semialdehyde dehydrogenase (NADP+) GabD (EC 1.2.1.79) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
gabD / P25526 succinate-semialdehyde dehydrogenase (NADP+) GabD (EC 1.2.1.79; EC 1.2.1.20) from Escherichia coli (strain K12) (see 22 papers)
GABD_ECOLI / P25526 Succinate-semialdehyde dehydrogenase [NADP(+)] GabD; SSDH; Glutarate-semialdehyde dehydrogenase; EC 1.2.1.79; EC 1.2.1.- from Escherichia coli (strain K12) (see 4 papers)
P25526 succinate-semialdehyde dehydrogenase (NADP+) (EC 1.2.1.79) from Escherichia coli K-12 (see paper)
GB|AAC75708.1 succinate-semialdehyde dehydrogenase [NAD(P)+]; EC 1.2.1.16 from Escherichia coli K12 (see 5 papers)
NP_417147 succinate-semialdehyde dehydrogenase (NADP(+)) GabD from Escherichia coli str. K-12 substr. MG1655
b2661 succinate-semialdehyde dehydrogenase I, NADP-dependent from Escherichia coli str. K-12 substr. MG1655
38% identity, 99% coverage
- function: Catalyzes the NADP(+)-dependent oxidation of succinate semialdehyde to succinate (PubMed:20174634). Thereby functions in a GABA degradation pathway that allows some E.coli strains to utilize GABA as a nitrogen source for growth (PubMed:7011797). Also catalyzes the conversion of glutarate semialdehyde to glutarate, as part of a L- lysine degradation pathway that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate (PubMed:30498244).
catalytic activity: H2O + NADP(+) + succinate semialdehyde = 2 H(+) + NADPH + succinate (RHEA:13213)
catalytic activity: 5-oxopentanoate + H2O + NADP(+) = glutarate + 2 H(+) + NADPH (RHEA:57832)
subunit: Homotetramer. - Insufficient Acetyl-CoA Pool Restricts the Phototrophic Production of Organic Acids in Model Cyanobacteria
You, International journal of molecular sciences 2024 - Metabolic engineering of a fast-growing cyanobacterium Synechococcus elongatus PCC 11801 for photoautotrophic production of succinic acid.
Sengupta, Biotechnology for biofuels 2020 - “...NSI site of S. elongatus PCC 11801 chromosome. The locus tag are: OgdA -Synpcc7002_A2770, SsaD -P25526, and PEPC -Synpcc7942_2252. c Schematic showing homologous recombination of a construct of Synpcc7942_0612 ( gltA ), Synpcc7942_0505 ( SBPase ) at the glgA site. d Schematic showing homologous recombination of...”
- “...sites where constructs are integrated b The locus tag/Uniprot identifiers as follows OgdA (Synpcc7002_A2770), SsaD (P25526), PEPC (Synpcc7942_2252), gltA (Synpcc7942_0612), Sbpase ( Synpcc7942_0505), yjjP (POADD2) and yjjB (POADD5) Xknockout/disrupted site genes overexpressed The genes overexpressed in PCC 11801 were chromosomally integrated along with antibiotic markers [...”
- A curated C. difficile strain 630 metabolic network: prediction of essential targets and inhibitors.
Larocque, BMC systems biology 2014 - “...(gapB) P0A9B2 [52%] O14556 [47%] BRZ, NMD, TND (O14556 [44%]); AES (P04406 [49%]) gapB (gapA) P25526 [35%] P00352 [35%] APR, SND, AES (P04406 [49%]); BRZ, NMD, TND (O14556 [47%]) uppS (CD2762) P0A825 [56%] P34897-3 [45%] B08, B28, B29, B76, FPP, FPS, IPE (P60472 [44%]); GPP (P60379...”
- Functional versatility and molecular diversity of the metabolic map of Escherichia coli
Tsoka, Genome research 2001 - “...P17445 BETAINE ALDEHYDE DEHYDROGENASE 1.2.1.16 P25526 SUCCINATE-SEMIALDEHYDE DEHYDROGENASE [NADP+] 1.2.1.21 1.2.1.22 P25553 ALDEHYDE DEHYDROGENASE A 1.2.1.22...”
- Characterization of the p-toluenesulfonate operon tsaMBCD and tsaR in Comamonas testosteroni T-2
Junker, Journal of bacteriology 1997 - “...ND Tetramer Dimer ND 58 54 51 ND 55 P25526 X95396 P25553 P15437 A55684 a Mr,calc, molecular weight calculated from amino acid composition. The total number of...”
- Purification and molecular characterization of the NAD(+)-dependent acetaldehyde/alcohol dehydrogenase from Entamoeba histolytica
Bruchhaus, The Biochemical journal 1994 - “...Schulz, A. and Bartsch, K. (1992) SwissProt accession no. P25526 29 Hidalgo, E., Chen, Y.-M., Lin, E. C. C. and Aguilar, J. (1991) J. Bacteriol. 173, 6118-6123...”
- Subtraction hybridisation and shot-gun sequencing: a new approach to identify symbiotic loci
Perret, Nucleic acids research 1994 - “...dehydrogenase from E.coli (Swissprot accession number P25526), a methyl-accepting chemotaxis protein from Caulobacter crescentus (23), the UGPC protein...”
- Molecular characterization of an aldehyde/alcohol dehydrogenase gene from Clostridium acetobutylicum ATCC 824
Nair, Journal of bacteriology 1994 - “...Schulz, and K. Bartsch. 1992. SwissProt accession no. P25526. 35. Palosaari, N. R., and P. Rogers. 1988. Purification and properties of the inducible coenzyme...”
- Kinetic and structural insights into enzymatic mechanism of succinic semialdehyde dehydrogenase from Cyanothece sp. ATCC51142
Xie, PloS one 2020 - “...from Samlonella typhimurium (NP_460484), YneI from E . coli (WP_115463367), GabD from E . coli (NP_417147), GabD from Human (NP_001071), GabD from A . thaliana (NP_178062), YneI from Bacillus subtilis (ARW30050). Triangle indicates residues involved in cofactor preference, and pentagram indicates residues involved in enzyme catalysis....”
- Structural basis for a cofactor-dependent oxidation protection and catalysis of cyanobacterial succinic semialdehyde dehydrogenase
Park, The Journal of biological chemistry 2013 - “...EcSSADH for E. coli SSADH (gene accession no. NP_417147), AtSSADH for A. thaliana SSADH (gene accession no. NP_178062), and HsSSADH for human SSADH (gene...”
- Crystal structure of non-redox regulated SSADH from Escherichia coli.
Ahn, Biochemical and biophysical research communications 2010 (PubMed)- GeneRIF: the crystal structure of EcSSADH, revealing that the catalytic loop of EcSSADH, unlike that of human SSADH, was presented.
- The X-ray crystal structure of Escherichia coli succinic semialdehyde dehydrogenase; structural insights into NADP+/enzyme interactions.
Langendorf, PloS one 2010 - GeneRIF: Data suggest that a deletion of three amino acids in gabD gene (SSADH) permits this enzyme to use NADP+.
- Polyamine and Ethanolamine Metabolism in Bacteria as an Important Component of Nitrogen Assimilation for Survival and Pathogenicity
Krysenko, Medical sciences (Basel, Switzerland) 2022 - “...-aminobutyrate aminotransferase gabT-like or puuE-like GabT (b2662)/PuuE (b1302) GabT (PA266) SCO5676 Succinate-semialdehyde dehydrogenase gabD-like GabD (b2661) GabD (PA0265) SCO5679 Amino acids/polyamine permease PuuP (b1296) PA5510/PAO322 SCO5977 Hydrolase - - SCO6960 Amidohydrolase - - SCO6961 -glutamyl-polyamine synthetase PuuA (b1297) PauA7 (PA5508)/SpuI (PA0296) SCO6962 medsci-10-00040-t002_Table 2 Table 2...”
- Gap-filling analysis of the iJO1366 Escherichia coli metabolic network reconstruction for discovery of metabolic functions
Orth, BMC systems biology 2012 - “...none identified pabC (b1096) ilvE (b3770) 7.00E-8 icd (b1136) dmlA (b1800) 3.00E-19 aldA (b1415) gabD (b2661) 1.00E-90 prr (b1444) 3.00E-80 feaB (b1385) 1.00E-69 aldB (b3588) 2.00E-66 betB (b0312) 4.00E-65 ubiX (b2311) none identified luxS (b2687) none identified thyA (b2827) none identified zupT (b3040) none identified folB...”
- In vitro transcription profiling of the σS subunit of bacterial RNA polymerase: re-definition of the σS regulon and identification of σS-specific promoter sequence elements
Maciag, Nucleic acids research 2011 - “...Polyamine metabolism puuB -glutamylputrescine oxidase b1301 1.61 S ( 19 ) gabD Succinate semialdehyde dehydrogenase b2661 1.65 S , Nac ( 9 , 66 ) speB Agmatinase (in arginine/putrescine degradation pathway) b2937 1.66 Transcription regulation IG582284_582903-f Intergenic region including appY promoter N.A. 1.69 H-NS ( 67...”
- Systematizing the generation of missing metabolic knowledge
Orth, Biotechnology and bioengineering 2010 - “...top candidate ( Fuhrer et al. 2007 ). A yneI strain along with a gabD (b2661) strain (missing the known gene encoding NADP + -dependent SSADH) were grown in M9 glycerol media with GABA as the only nitrogen source. Both strains grew to lower concentrations than...”
- Homotaurine metabolized to 3-sulfopropanoate in Cupriavidus necator H16: enzymes and genes in a patchwork pathway
Mayer, Journal of bacteriology 2009 - “...dehydrogenase; NAD(P)] (EC 1.2.1.16; b2661), whose structure is available online (http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId 3ETF). In...”
- Reconfiguring the quorum-sensing regulator SdiA of Escherichia coli to control biofilm formation via indole and N-acylhomoserine lactones
Lee, Applied and environmental microbiology 2009 - “...b1744 b1745 b1746 b1747 b1748 b2000 b2097 b2210 b2465 b2661 b2662 b2663 b2724 b2873 b3012 b3049 b3175 b3230 b3311 b3426 b3447 b3453 b1488 b3540 b3541 b3542...”
- The Crp-activated small noncoding regulatory RNA CyaR (RyeE) links nutritional status to group behavior
De, Journal of bacteriology 2009 - “...b1740 b1820 2,776.2 388.8 450.9 176.5 yeeD gabD b2012 b2661 3,063.7 531.3 ygaU b2665 yqaE Locus uspG modC b0607 b0765 951.8 297.3 ompX b0814 gsiB Level when...”
- Genome-wide analysis of the general stress response network in Escherichia coli: sigmaS-dependent genes, promoters, and sigma factor selectivity
Weber, Journal of bacteriology 2005 - “...conditions Function (reference) and gene b1478 b1927 b3012 b2097 b2661 b1619 b2720 b0186 b1469 b1467 b0871 b4051 b2464 b1519 b2465 b3449 b0485 ybaY ycaC yfcF...”
WP_153256127 aldehyde dehydrogenase DhaS from Bacillus subtilis
39% identity, 95% coverage
ALDH4_BACSU / O34660 Putative aldehyde dehydrogenase DhaS; EC 1.2.1.3 from Bacillus subtilis (strain 168) (see paper)
BSU19310 putative aldehyde dehydrogenase from Bacillus subtilis subsp. subtilis str. 168
39% identity, 95% coverage
AS588_RS05800 aldehyde dehydrogenase family protein from Bacillus amyloliquefaciens
39% identity, 95% coverage
WP_105285925 NADP-dependent succinate-semialdehyde dehydrogenase from Escherichia coli
38% identity, 99% coverage
- Fitness cost of a mcr-1-carrying IncHI2 plasmid
Ma, PloS one 2018 - “...competition J53 LB CT (-) spacer 3 GC (T208S) gabD NADP-dependent succinate- semialdehyde dehydrogenase I WP_105285925 catalyzes the NADP+-dependent oxidation of succinate semialdehyde to succinate. CT (-) mprA transcriptional regulator WP_000378442 M9 CT (A86 * ) orf DUF1116 domain-containing protein WP_000083429 unknown 1 aa sub, amino...”
PSPTO0300 succinate-semialdehyde dehydrogenase from Pseudomonas syringae pv. tomato str. DC3000
37% identity, 98% coverage
V529_19360 aldehyde dehydrogenase family protein from Bacillus velezensis SQR9
39% identity, 95% coverage
- Analysis and cloning of the synthetic pathway of the phytohormone indole-3-acetic acid in the plant-beneficial Bacillus amyloliquefaciens SQR9
Shao, Microbial cell factories 2015 - “...ydaP (V529_04190), pycA (V529_14260), padC (V529_34370), yclB (V529_03390), yclC (V529_03400) IAAld dehydrogenase aldX (V529_39560), dhaS (V529_19360), yfmT (V529_06950), ywdH (V529_29500) IAM Trp mono-oxygenase Not detected IAM hydrolase Not detected TAM Trp decarboxylase ydaP (V529_04190), pycA (V529_14260), padC (V529_34370), yclB (V529_03390), yclC (V529_03400) Amine oxidase Not detected...”
ECs3522 succinate-semialdehyde dehydrogenase from Escherichia coli O157:H7 str. Sakai
Z3959 succinate-semialdehyde dehydrogenase, NADP-dependent activity from Escherichia coli O157:H7 EDL933
38% identity, 99% coverage
RCF35_14870 aldehyde dehydrogenase family protein from Bacillus velezensis
38% identity, 95% coverage
- Whole genome sequencing data of the submerged macrophytes growth promoting and aerobic denitrifying bacterium Bacillus velezensis NBNZ-0060
Chen, Data in brief 2024 - “...decarboxylase RCF35_07465, RCF35_12695 ( pyc ), RCF35_01945, RCF35_07080, RCF35_07085 ( bsdC ) indole-3-acetaldehyde dehydrogenase RCF35_04555, RCF35_14870, RCF35_08890, RCF35_18825 tryptamine pathway tryptophan decarboxylase RCF35_07465, RCF35_12695 ( pyc ), RCF35_01945, RCF35_07080, RCF35_07085 ( bsdC ) indole-3-acetaldehyde dehydrogenase RCF35_04555, RCF35_14870, RCF35_08890, RCF35_18825 indole-3-acetonitrile pathway nitrilase RCF35_09895 Others tryptophan acetyltransferase...”
Q4WPA5 Aldehyde dehydrogenase, putative from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293)
Afu4g08600 aldehyde dehydrogenase, putative from Aspergillus fumigatus Af293
38% identity, 85% coverage
- Identifying Potential Molecular Targets in Fungi Based on (Dis)Similarities in Binding Site Architecture with Proteins of the Human Pharmacolome
Bedoya-Cardona, Molecules (Basel, Switzerland) 2023 - “...Q4WWH7 76 A0A2H0ZYL6 77 G8BAQ2 76 Q5KKP1 77 A0A0D2XNJ1 77 Succinate dehydrogenase P51649 F0U4T1 72.2 Q4WPA5 78 Q6FVP8 81 G8B862 78 Q5K8N2 81 A0A0D2Y168 88 CFTR P13569 F0ULL9 72 Q4WIK7 74 Q6FWS5 79 Q5KL35 78 DPDE4 Q07343 F0UHN7 71.4 FADK 2 Q14289 F0UKJ3 70.8 Q4X028 76...”
- Transcript levels of the Aspergillus fumigatus Cdc42 module, polarisome, and septin genes show little change from dormancy to polarity establishment
Oda, Medical mycology 2017 - “...Afu3g08710 Afu1g14930 Afu6g03050 Afu2g13210 Afu5g03230 Afu4g08600 Afu2g05560 Afu3g11030 Afu2g10420 integral membrane protein, putative antigenic thaumatin...”
- Transcriptomic and proteomic analyses of the Aspergillus fumigatus hypoxia response using an oxygen-controlled fermenter
Barker, BMC genomics 2012 - “...aldehyde dehydrogenase encoding genes in A. fumigatus , Afu2g00720 and Afu7g01000 (NAD + ) and Afu4g08600 and Afu4g13500 (NAD(P) + ), so it is possible that these enzymes, and not AldA, are utilized under hypoxic conditions to metabolize ethanol. Afu4g08600 does show a gradual increase in...”
SE2166 glycine betaine aldehyde dehydrogenase gbsA from Staphylococcus epidermidis ATCC 12228
36% identity, 94% coverage
AO090023000467 No description from Aspergillus oryzae RIB40
39% identity, 94% coverage
- Versatile filamentous fungal host highly-producing heterologous natural products developed by genome editing-mediated engineering of multiple metabolic pathways
Saito, Communications biology 2024 - “...these enzymes of A. oryzae were identified as follows; AO090003000661 for PDC, AO090003001112 for ACS, AO090023000467 for ALD, and AO090009000634 for ADH (Supplementary Table 1 ). Therefore, these genes were deleted from the pleuromutilin-producing strain (Supplementary Fig. 5 ). The deletion of pdc and adh involved...”
- Genomic and transcriptomic comparison of Aspergillus oryzae strains: a case study in soy sauce koji fermentation
Zhong, Journal of industrial microbiology & biotechnology 2018 - “...4.1.1.1 Pyruvate decarboxylase 0.31 1.64 1.50 9 AO090003000261 1.1.1.1 Alcohol dehydrogenase 2.45 1.29 2.33 10 AO090023000467 1.2.1.3 Aldehyde dehydrogenase 1.03 0.85 0.14 10 AO090026000741 1.2.1.5 Aldehyde dehydrogenase 1.13 0.19 0.80 11 AO090003000174 4.1.1.49 Phosphoenolpyruvate carboxykinase 1.90 4.62 0.96 12 AO090023000801 6.4.1.1 Pyruvate carboxylase 0.16 1.39 0.51...”
- “...AO090001000143 , AO090701000542 ), fatty acid synthase ( fas1 , AO090011000046 ), aldehyde dehydrogenase ( AO090023000467 ), and alcohol dehydrogenases ( AO090003000261 , AO090003001407 ) were up-regulated in RD2. The up-regulation of these enzymes largely induced the accumulation of fatty acids, which can be further catabolized...”
- Survey of the transcriptome of Aspergillus oryzae via massively parallel mRNA sequencing
Wang, Nucleic acids research 2010 - “...And it seemed that the conversion of pyruvate to acetate was also repressed because aldA (AO090023000467, responsible for oxidizing acetaldehyde to acetate) was downregulated on SC ( Supplementary Table S10 ). So, the flux of pyruvate in A. oryzae was targeted to the TCA cycle and...”
WP_013623073 aldehyde dehydrogenase family protein from Deinococcus proteolyticus MRP
36% identity, 87% coverage
ABC0047 aldehyde dehydrogenase from Bacillus clausii KSM-K16
40% identity, 94% coverage
RBAM_019060 DhaS from Bacillus amyloliquefaciens FZB42
38% identity, 95% coverage
- Linking plant nutritional status to plant-microbe interactions
Carvalhais, PloS one 2013 - “...RBAM_035760 licH 6.6 187.6 -Fe RBAM_036760 iolC 2.5 21.3 -Fe RBAM_030250 yvqH 4.3 9.6 -Fe RBAM_019060 dhaS 3.2 3.6 -Fe RBAM_035790 licB 3.3 111.0 -P RBAM_032550 flgL 2.4 2.8 -P RBAM_032490 fliS 2.5 2.7 -P RBAM0_36710 iolH 2.5 9.9 -P RBAM_018960 yocH 3.2 2.7 -N RBAM_001110...”
- “...RBAM_036710 iolH 4.7 28.5 -N RBAM_002320 glmS 2.2 2.3 -N RBAM_018960 yocH 2.0 1.9 -K RBAM_019060 dhaS 2.1 68.6 -K RBAM_036760 iolC 2.1 244.0 -K RBAM_018960 yocH 2.7 22.1 -K RBAM_030250 yvqH 5.5 305.8 Root exudates from the iron deficiency treatment are represented as -Fe, phosphorus...”
SERP2177 betaine aldehyde dehydrogenase from Staphylococcus epidermidis RP62A
SERP_RS10790 betaine-aldehyde dehydrogenase from Staphylococcus epidermidis RP62A
36% identity, 94% coverage
Q88RC0 glutarate-semialdehyde dehydrogenase (EC 1.2.1.20) from Pseudomonas putida (see 2 papers)
PP0213 succinate-semialdehyde dehydrogenase from Pseudomonas putida KT2440
PP_0213 NADP-dependent succinate-semialdehyde dehydrogenase from Pseudomonas putida KT2440
38% identity, 98% coverage
- UEG Week 2024 Poster Presentations
, United European gastroenterology journal 2024 - UEG Week 2023 Poster Presentations
, United European gastroenterology journal 2023 - Genome-scale reconstruction and analysis of the Pseudomonas putida KT2440 metabolic network facilitates applications in biotechnology
Puchałka, PLoS computational biology 2008 - “...3 List of genes reannotated during the reconstruction process. Gene Old Annotation New Annotation Reference PP0213 Succinate-semialdehyde dehydrogenase; EC:1.2.1.16 Glutarate-semialdehyde; dehydrogenase EC 1.2.1.20 [36] PP0214 4-Aminobutyrate aminotransferase; EC:2.6.1.19, EC:2.6.1.22 5-Aminovalerate transaminase; EC 2.6.1.48 [36] PP0382 Carbon-nitrogen hydrolase family protein 5-Aminopentanamidase; EC 3.5.1.30 [36] PP0383 Tryptophan 2-monooxygenase,...”
- Functional genomics of stress response in Pseudomonas putida KT2440
Reva, Journal of bacteriology 2006 - “...the cellular levels of succinate semialdehyde dehydrogenase (DavD, PP0213) (63). Hence, PP0213 and PP3724, the paralog of the succinyl-CoA synthetase gene, may...”
- Multiple and interconnected pathways for L-lysine catabolism in Pseudomonas putida KT2440
Revelles, Journal of bacteriology 2005 - “...12, 2017 by University of California, Berkeley davD (PP0213) davT (PP214) davB (PP0383) davA (PP0382) amaA (PP5257) amaB (PP5258) cadA (PP4140) Periplasmic...”
- Proteomic analysis reveals the participation of energy- and stress-related proteins in the response of Pseudomonas putida DOT-T1E to toluene
Segura, Journal of bacteriology 2005 - “...protein CspA todC1 todF gabD sucC lpdG PPUY18245 PPUY18245 PP0213 PP4186 PP4187 51.3 30.8 51.8 41.5 50.1 fda pflu3720b ppa tuf-1 PP4960 Pflu3720 PP0538 PP0440...”
- Production of selenium nanoparticles occurs through an interconnected pathway of sulphur metabolism and oxidative stress response in Pseudomonas putida KT2440
Avendaño, Microbial biotechnology 2023 - “...enzymes responsible for transforming GABA to succinate semialdehyde (PP_0214 and PP_2799) and succinate semialdehyde succinate (PP_0213, PP_2488, PP_3151 and PP_4422) are present. However, an enzyme with glutamate decarboxylase activity responsible for transforming glutamate to GABA has not been described. Although there is no annotated enzyme for...”
- Nitrogen Metabolism in Pseudomonas putida: Functional Analysis Using Random Barcode Transposon Sequencing
Schmidt, Applied and environmental microbiology 2022 (secret) - Unraveling 1,4-Butanediol Metabolism in Pseudomonas putida KT2440
Li, Frontiers in microbiology 2020 - “...oxidation step. The resulting succinate semialdehyde can be oxidized by the annotated succinate semialdehyde dehydrogenases PP_0213 (GabD-I) and PP_3151 (SadI), but also possibly by the methylmalonate-semialdehyde dehydrogenase PP_4667 (MmsA-II). The resulting oxidation product succinate can be further metabolized in the TCA cycle. The low growth rate...”
- Systems metabolic engineering of Corynebacterium glutamicum for the production of the carbon-5 platform chemicals 5-aminovalerate and glutarate
Rohles, Microbial cell factories 2016 - “...by BLASTX search using sequence information of the P. putida genes gabT ( davT , PP_0213) a and gabD ( davD , PP_0214) b Results Recombinant expression of the davBA genes establishes 5-aminovalerate and glutarate production in C. glutamicum Upon implementation of the P. putida genes...”
- “...of C. glutamicum , the corresponding gene sequences from P. putida (PP_0214, gabT, davT and PP_0213, gabD, davD ) were BLASTed (BLASTX, http://www.genome.jp/tools/blast/ ) against the C. glutamicum genome, deposited at KEGG ( http://www.genome.jp/kegg/ ). The genetic construct for genome-based integration of the davBA gene cluster...”
CNAG_06628 aldehyde dehydrogenase (NAD) from Cryptococcus neoformans var. grubii H99
40% identity, 93% coverage
- Cryptococcus neoformans resists to drastic conditions by switching to viable but non-culturable cell phenotype
Hommel, PLoS pathogens 2019 - “...Metabolic pathways Genes Corrected p value (FDR 1%) Fatty acid degradation CNAG_00490, CNAG_00524, CNAG_03019, CNAG_02489, CNAG_06628, CNAG_07747, CNAG_04531, CNAG_04688 1.20E-09 Valine, leucine and isoleucine degradation CNAG_00484, CNAG_00490, CNAG_00524, CNAG_03067, CNAG_06628, CNAG_04531, CNAG_04351, CNAG_04688 2.40E-08 Fatty acid metabolism CNAG_00490, CNAG_00524, CNAG_03019, CNAG_07747, CNAG_04531, CNAG_04688 9.50E-07 Propanoate metabolism...”
- “...CNAG_04531, CNAG_04351, CNAG_04217, CNAG_04688 4.00E-05 Biosynthesis of secondary metabolites CNAG_00484, CNAG_00490, CNAG_00524, CNAG_00797, CNAG_03067, CNAG_02489, CNAG_06628, CNAG_04531, CNAG_04217, CNAG_04688, CNAG_06431 2.60E-04 Peroxisome CNAG_00537, CNAG_03067, CNAG_03019, CNAG_06551, CNAG_07747 2.90E-04 Metabolic pathways CNAG_00484, CNAG_00490, CNAG_00524, CNAG_00797, CNAG_00826, CNAG_03067, CNAG_03019, CNAG_01540, CNAG_02489, CNAG_06628, CNAG_07747, CNAG_05653, CNAG_05303, CNAG_04531, CNAG_04351, CNAG_04217,...”
- Characterization of Lipids and Proteins Associated to the Cell Wall of the Acapsular Mutant Cryptococcus neoformans Cap 67
Longo, The Journal of eukaryotic microbiology 2015 - “...CNAG_03482 peroxiredoxin Ca Sc CnSc CNAG_03618 NADPH2:quinone reductase Ca Sc HcSc CNAG_04981 catalase Pb CnHcPbSc CNAG_06628 aldehydedehydrogenase PbSc CnHcSc CNAG_06917 thiol-specific antioxidant protein 3 Ca Pb CnHcPb CNAG_00162 alternative oxidase, mitochondrial - - CNAG_03936 NAD(P)H:quinoneoxidoreductase, type IV - PbSc CNAG_05753 N-acetyl-gamma-glutamyl-Preductase - - CNAG_05721 multifunctional beta-oxidation...”
- Brain inositol is a novel stimulator for promoting Cryptococcus penetration of the blood-brain barrier
Liu, PLoS pathogens 2013 - “...CNH03280 CNAG_05303 Isocitrate lyase 5.27 CNA00470 CNAG_00057 Fructose-1,6-bisphosphatase 5.02 CNA04370 CNAG_00457 Glutamine synthetase 4.41 CNF03900 CNAG_06628 Aldehyde dehydrogenase 4.31 CNC02480 CNAG_01745 sn-Glycerol-3-phosphate dehydrogenase 3.52 CNF04450 CNAG_07660 Pyruvate dehydrogenase 3.51 CNA01050 CNAG_00115 Sorbitol dehydrogenase 3.33 CNJ00950 CNAG_04659 Pyruvate decarboxylase 3.23 CNG00600 CNAG_07745 Mannitol-1-phosphate dehydrogenase 3.00 CNC06440 CNAG_01539...”
- The transcriptional response of Cryptococcus neoformans to ingestion by Acanthamoeba castellanii and macrophages provides insights into the evolutionary adaptation to the mammalian host
Derengowski, Eukaryotic cell 2013 - “...CNAG_00371 CNAG_04308 CNAG_01671 CNAG_00499 CNAG_06628 CNAG_02087 Long-chain-fatty-acid-CoA ligase Acyl-CoA oxidase Acetyl-CoA C-acyltransferase Acyl-CoA...”
PSPTO_2673 aldehyde dehydrogenase family protein from Pseudomonas syringae pv. tomato str. DC3000
38% identity, 96% coverage
- Investigating the biosynthesis and roles of the auxin phenylacetic acid during Pseudomonas syringae-Arabidopsis thaliana pathogenesis
Lee, Frontiers in plant science 2024 - “...mutant by triparental mating and selecting for Km- and Spec-resistant colonies. Disruption of aldB ( PSPTO_2673) by pJP5603 was confirmed by PCR using primers M13F and 2673SeqF. 2.3 Feeding P. syringae with PAAld Wild-type Pto DC3000 and mutant strains were grown in NYG medium without antibiotics...”
- The plant pathogen enzyme AldC is a long-chain aliphatic aldehyde dehydrogenase
Lee, The Journal of biological chemistry 2020 (secret) - Investigating the reaction and substrate preference of indole-3-acetaldehyde dehydrogenase from the plant pathogen Pseudomonas syringae PtoDC3000
Zhang, Bioscience reports 2020 - “...encoding an ALDH. Subsequent examination of Pto DC3000 identified three ALDHsAldA (UniProt: PSPTO_0092), AldB (UniProt: PSPTO_2673), and AldC (UniProt: PSPTO_3644)that are related by 3040% amino acid identity [ 18 ]. AldA from Pto DC3000 was determined to function as an indole-3-acetaldehyde dehydrogenase through comprehensive metabolic, biochemical,...”
- Indole-3-acetaldehyde dehydrogenase-dependent auxin synthesis contributes to virulence of Pseudomonas syringae strain DC3000
McClerklin, PLoS pathogens 2018 - “...PSPTO_0728 sequence to search the DC3000 genome and identified 5 additional putative ALD homologs, PSPTO_0092, PSPTO_2673, PSPTO_3064, PSPTO_3323, and PSPTO_3644, with ~3040% amino acid identity to PSPTO_0728. None of these proteins had previously been demonstrated to have dehydrogenase activity, nor were they described as involved in...”
- “...we observed increased IAA levels for three of the six proteins. The strains expressing either PSPTO_2673 or PSPTO_3644 showed ~10- and 5-fold increases in IAA levels, respectively ( Fig 2A ). Cells expressing PSPTO_0092 showed the greatest accumulation of IAA with an ~200-fold increase in IAA...”
O74187 Aldehyde dehydrogenase from Agaricus bisporus
37% identity, 94% coverage
PP_3646 aldehyde dehydrogenase family protein from Pseudomonas putida KT2440
38% identity, 96% coverage
FGSG_02273 aldehyde dehydrogenase from Fusarium graminearum PH-1
37% identity, 94% coverage
Cbei_4936 aldehyde dehydrogenase from Clostridium beijerincki NCIMB 8052
38% identity, 95% coverage
- Transcriptional analysis of degenerate strain Clostridium beijerinckii DG-8052 reveals a pleiotropic response to CaCO3-associated recovery of solvent production
Jiao, Scientific reports 2016 - “...in their expression in response to CaCO 3 . The aldehyde dehydrogenase (Cbei_2518, Cbei_0305 and Cbei_4936) showed up-regulation folds from +4.33, +3.36, +164.7 (acidogenisis) to +4.83, +4.01, +39.86 (solventogensis), separately. Alcohol dehydrogenase (Cbei_4552, Cbei_4354 and Cbei_1937) were also all up-transcripted from +3.42, +8.44, +159.77 (acidogenisis) to...”
OGAPODRAFT_16764 aldehyde dehydrogenase from Ogataea polymorpha
38% identity, 91% coverage
SXYL_00225 betaine-aldehyde dehydrogenase from Staphylococcus xylosus
35% identity, 94% coverage
- Investigating Extracellular DNA Release in Staphylococcus xylosus Biofilm In Vitro
Leroy, Microorganisms 2021 - “...TO STRESS Osmotic SXYL_00223 cudT Choline transporter 2.4 SXYL_00224 cudC Putative transcriptional regulator 4.9 5.6 SXYL_00225 cudA Glycine betaine aldehyde dehydrogenase 21.1 21.4 SXYL_00226 betA Oxygen-dependent choline dehydrogenase 13.4 12.3 SXYL_02221-26 mnhF2E2D2C2B2A2 Na(+)/H(+) antiporter 2.7 * SXYL_02219 Putative NhaP-type Na+ H+ and K+ H+ antiporter 2.1...”
4neaA / A0A0H2X0S3 1.90 angstrom resolution crystal structure of betaine aldehyde dehydrogenase (betb) from staphylococcus aureus in complex with NAD+ and bme-free cys289 (see paper)
35% identity, 92% coverage
- Ligand: nicotinamide-adenine-dinucleotide (4neaA)
Q9L4P8 betaine-aldehyde dehydrogenase (EC 1.2.1.8) from Staphylococcus aureus (see paper)
SACOL2628 betaine aldehyde dehydrogenase from Staphylococcus aureus subsp. aureus COL
SAOUHSC_02933 betaine aldehyde dehydrogenase from Staphylococcus aureus subsp. aureus NCTC 8325
SAUSA300_2546 glycine betaine aldehyde dehydrogenase from Staphylococcus aureus subsp. aureus USA300_FPR3757
MW2532 glycine betaine aldehyde dehydrogenase gbsA from Staphylococcus aureus subsp. aureus MW2
NWMN_2510 glycine betaine aldehyde dehydrogenase from Staphylococcus aureus subsp. aureus str. Newman
CH51_RS14770 betaine-aldehyde dehydrogenase from Staphylococcus aureus
35% identity, 94% coverage
- Apt (Adenine Phosphoribosyltransferase) Mutation in Laboratory-Selected Vancomycin-Intermediate Staphylococcus aureus
Lamichhane-Khadka, Antibiotics (Basel, Switzerland) 2021 - “...B ND 2.2 SACOL2581 ssaA2 ssaA homolog ND 3.1 SACOL2627 betA Choline dehydrogenase ND 7.4 SACOL2628 betB Glycine betaine aldehyde dehydrogenase ND (2.2) 9.2 (7.0) SACOL2632 opuD2 BCCT family osmoprotectant transporter ND 4.6 a Gene ID correspond to strain COL genome. Abbreviations: ND, transcriptional alteration not...”
- Structural and functional analysis of betaine aldehyde dehydrogenase from Staphylococcus aureus
Halavaty, Acta crystallographica. Section D, Biological crystallography 2015 - “...of this article is available from Crystallography Journals Online. The purified putative betaine aldehyde dehydrogenase SACOL2628 from the early methicillin-resistant S. aureus COL has betaine aldehyde dehydrogenase activity and is structurally similar to aldehyde dehydrogenases. When exposed to high osmolarity, methicillin-resistant Staphylococcus aureus (MRSA) restores its...”
- “...betaine aldehyde dehydrogenase (BADH) enzymes. Here, it is shown that the putative betaine aldehyde dehydrogenase SACOL2628 from the early MRSA isolate COL ( Sa BADH) utilizes betaine aldehyde as the primary substrate and nicotinamide adenine dinucleotide (NAD + ) as the cofactor. Surface plasmon resonance experiments...”
- In vitro and in vivo models of Staphylococcus aureus endophthalmitis implicate specific nutrients in ocular infection
Sadaka, PloS one 2014 - “...upstream of SACOL2620 34.3 (1.3) 7.9 (3.4) 20.4 (2.1) SACOL2627 betA Choline dehydrogenase 5.0 (2.4) SACOL2628 betB Betaine aldehyde dehydrogenase 5.4 (2.4) SACOL2641 gpxA2 Glutathione peroxidase 6.4 (1.4) ig_SACOL2641-2 Intergenic region betweenSACOL2642 and gpxA2 (SACOL2641) 8.3 (1.6) ig_SACOL2641-2 rev comp Reverse complement of intergenicregion between SACOL2642...”
- Tea tree oil-induced transcriptional alterations in Staphylococcus aureus
Cuaron, Phytotherapy research : PTR 2013 - “...qRT-PCR experiments Gene Function Locus ID Primer sequence (forward and reverse) betB betaine aldehyde dehydrogenase SACOL2628 5-AATTGCTGTTGGTGGTAAACG-3 5-TAACGACAGGTCCGAAAACC-3 dnaK DnaK protein SACOL1637 5-CCGGTGACAACAAACTTGG-3 5-TCAGCAGCATCTTTCAAACG-3 mmpL MmpL efflux pump, putative SACOL2566 5-GGAATGACATCTACAGAAGTAGGC-3 5-AACTGCTAGTCCAATCATTACGG-3 purA adenylosuccinate synthase SACOL0018 5-GAGGTTGGTCGTGAATACGG-3 5-TGGGTACTCAGTAATTTCTTTACCG-3 purM phosphoribosylaminoimidazole synthetase SACOL1080 5-AATATGGGTATTGGCTATACGG-3 5-CACAATATGACCAATTTGATAGGC-3 rpmI ribosomal...”
- “...amidotransferase SACOL1079 7.2 similar to xanthine/uracil permease family protein SACOL2242 7.1 betB betaine aldehyde dehydrogenase SACOL2628 7.0 1.5 1.6 hypothetical protein (191 aa) SACOL1086 7.0 rpmI ribosomal protein L35 SACOL1726 5.9 2.0 1.8 thiD phosphomethylpyrimidine kinase SACOL2085 5.1 purQ phosphoribosylformylglycinamidine synthase I SACOL1077 4.9 purC phosphoribosylaminoimidazole-succinocarboxamide...”
- Rbf promotes biofilm formation by Staphylococcus aureus via repression of icaR, a negative regulator of icaADBC
Cue, Journal of bacteriology 2009 - “...Fold change in rbf vs wt SACOL2627 SACOL2628 SACOL0302 MSRA252-SAR2036 SACOL2652 SACOL1168 SACOL2511 SACOL2003 SACOL2688 SACOL0600 SACOL0247 SACOL0248 SACOL0245...”
- Synthetic Cinnamides and Cinnamates: Antimicrobial Activity, Mechanism of Action, and In Silico Study
de, Molecules (Basel, Switzerland) 2023 - “...reductase Homology A7X0K2 saFABH 18 3-oxoacyl-[acyl-carrier-protein] synthase III PDB A0A5C0VWB1 saFLHA 18 Alcohol dehydrogenase Homology Q9L4P8 saGBSA 18 Betaine aldehyde dehydrogenase PDB A0A1Q8DC81 saPPTHL 18 Alpha,alpha-phosphotrehalase Homology (a) ID used for the target. (b) Description of the target. (c) Source of the protein structure: PDB from...”
- Teg58, a small regulatory RNA, is involved in regulating arginine biosynthesis and biofilm formation in Staphylococcus aureus
Manna, Scientific reports 2022 - “...threonine metabolism SAOUHSC_02716 Dethiobiotin, bioD1 107 230 2.15 SAOUHSC-02932 Choline dehydrogenase, betA 4988 879 5.67 SAOUHSC_02933 Betaine aldehyde dehydrogenase, gbsA 11,652 2229 5.22 Virulence factors SAOUHSC_01121 alpha-hemolysin, hla 3247 8832 2.72 SAOUHSC_00069 Immunoglobulin G binding protein A, spa 1108 3256 2.94 SAOUHSC_02710 Leukocidin S subunit, hlgC...”
- Bacteria Are New Targets for Inhibitors of Human Farnesyltransferase
Weber, Frontiers in microbiology 2021 - “...a hemin transport system permease protein (SAOUHSC_02641), and betB , encoding the betaine aldehyde dehydrogenase (SAOUHSC_02933) ( Figure 6 ). The treatment of S. aureus with lonafarnib induced no significant transcriptional changes ( Figure 6 ). Discussion In this study, we investigated the effect of the...”
- Staphylococcus aureus AI-2 quorum sensing associates with the KdpDE two-component system to regulate capsular polysaccharide synthesis and virulence
Zhao, Infection and immunity 2010 - “...SAOUHSC_00830 SAOUHSC_02596 SAOUHSC_00043 SAOUHSC_01548 SAOUHSC_02933 SAOUHSC_02761 SAOUHSC_01921 SAOUHSC_00971 SAOUHSC_02787 SAOUHSC_02865 Hypothetical...”
- “...SAOUHSC_01536 SAOUHSC_02311 SAOUHSC_02374 SAOUHSC_02468 SAOUHSC_00310 SAOUHSC_00312 SAOUHSC_02933 SAOUHSC_02173 VOL. 78, 2010 S. AUREUS AI-2 QUORUM SENSING 3511...”
- Roles of the Site 2 Protease Eep in Staphylococcus aureus
Cheng, Journal of bacteriology 2020 (secret) - The SaeR/S gene regulatory system is essential for innate immune evasion by Staphylococcus aureus
Voyich, The Journal of infectious diseases 2009 - “...ES MW2212 ureD urease accessory protein UreD 2.31 ES MW2531 betA choline dehydrogenase 2.52 ES MW2532 gbsA glycine betaine aldehyde dehydrogenase gbsA 3.13 ES III . Genes without defined function down-regulated in the saeR/S mutant strain during growth in TSB ID Putative Function Fold Decrease Growth...”
- NWMN2330 May Be Associated with the Virulence of Staphylococcus aureus by Increasing the Expression of hla and saeRS
Liu, Infection and drug resistance 2022 - “...metabolism NWMN_1348 2.9716 4.71E-55 7.73E-54 L-threonine dehydratase catabolic TdcB NWMN_1239 1.7232 6.55E-11 2.79E-10 Aspartokinase 3 NWMN_2510 1.3361 1.07E-49 1.51E-48 Betaine aldehyde dehydrogenase NWMN_2331 1.4893 7.89E-22 5.58E-21 Glycerate kinase NWMN_1441 1.4886 2.01E-43 2.57E-42 Aminomethyltransferase NWMN_1242 1.3081 1.86E-17 1.11E-16 Homoserine kinase NWMN_1241 1.1079 1.13E-24 9.04E-24 Threonine synthase NWMN_1240...”
- PurN Is Involved in Antibiotic Tolerance and Virulence in Staphylococcus aureus
Peng, Antibiotics (Basel, Switzerland) 2022 - “..., saeR , ilvA , NWMN_1873 , lukS , hla , hlgC , lukF , NWMN_2510 , NWMN_2262 , NWMN_2266 , NWMN_0485 , and NWMN_0845 ) for validation by RT-qPCR and the results confirmed the reliability of the transcriptome analysis ( Supplementary Table S2 ). The...”
- Sulfide Homeostasis and Nitroxyl Intersect via Formation of Reactive Sulfur Species in Staphylococcus aureus
Peng, mSphere 2017 - “...gntR 5.4 Gluconate operon repressor + NWMN_2408 SA2300 12.0 Hypothetical; putative transporter protein (glucaronic acid) NWMN_2510 SA2406 6.2 Glycine betaine aldehyde dehydrogenase GbsA NWMN_2513 SA2408 3.7 Putative choline transporter a See Table1 . b At least 2-fold induction with NaHS (see TableS1A; adjusted P value of...”
- Functional expression and extension of staphylococcal staphyloxanthin biosynthetic pathway in Escherichia coli
Kim, The Journal of biological chemistry 2012 - “...gbsA NWMN_2026 NWMN_0113 NWMN_1858 NWMN_1305 NWMN_0741 NWMN_1580 NWMN_2510 Not assigned Not assigned Carotenoid biosynthesis (this study) Amino acid metabolism...”
- Staphylococcus aureus PhoU Homologs Regulate Persister Formation and Virulence
Shang, Frontiers in microbiology 2020 - “...small chain 0.38 ND Glycine, serine, and threonine metabolism CH51_RS14765 Oxygen-dependent choline dehydrogenase 2.71 ND CH51_RS14770 Betaine-aldehyde dehydrogenase 3.33 ND ND, not done. FIGURE 2 Proteinprotein interaction network. Up-regulated or down-regulated differentially expressed genes are indicated in red or green, respectively. The size of the node...”
MED193_21681 betaine aldehyde dehydrogenase from Roseobacter sp. MED193
A3XF87 Betaine-aldehyde dehydrogenase from Roseobacter sp. MED193
38% identity, 96% coverage
- Bacterial catabolism of membrane phospholipids links marine biogeochemical cycles
Westermann, Science advances 2023 - “...0.00 1.19 0.00 MED193_21676 A3XF95 BetC, choline sulfatase 1.16 0.00 + 2.34 0.00 0.60 0.00 MED193_21681 A3XF87 BetB, betaine aldehyde dehydrogenase 1.65 0.01 + 2.74 0.01 0.21 0.00 MED193_21686 A3XF88 BetA, choline dehydrogenase 0.44 0.00 + 2.45 0.00 0.36 0.00 * P value < 0.05 (+)...”
- “...transcriptional regulator (MED193_21666); BetT: choline transporter (MED193_21671), BetC: choline sulfatase (MED193_21676); BetB: betaine aldehyde dehydrogenase (MED193_21681); BetA: choline dehydrogenase (MED193_21686); ChoW: ABC-type transporter, permease component (MED193_07693); ChoV: ABC-type transporter, ATP-binding component (MED193_07698); ChoX: ABC-type transporter, betaine/carnitine/choline binding protein (MED193_07703); RpiR: RpiR regulator (MED193_10021); GGAH: -glutamylglycine amidohydrolase...”
- Bacterial catabolism of membrane phospholipids links marine biogeochemical cycles
Westermann, Science advances 2023 - “...1.19 0.00 MED193_21676 A3XF95 BetC, choline sulfatase 1.16 0.00 + 2.34 0.00 0.60 0.00 MED193_21681 A3XF87 BetB, betaine aldehyde dehydrogenase 1.65 0.01 + 2.74 0.01 0.21 0.00 MED193_21686 A3XF88 BetA, choline dehydrogenase 0.44 0.00 + 2.45 0.00 0.36 0.00 * P value < 0.05 (+) and...”
SAR2691 putative betaine aldehyde dehydrogenase from Staphylococcus aureus subsp. aureus MRSA252
35% identity, 94% coverage
Q6FVP8 Candida glabrata strain CBS138 chromosome D complete sequence from Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)
38% identity, 89% coverage
MAA_02517 aldehyde dehydrogenase from Metarhizium robertsii ARSEF 23
39% identity, 89% coverage
MOC_0592 aldehyde dehydrogenase from Methylobacterium oryzae CBMB20
40% identity, 86% coverage
A0A0D2Y168 Uncharacterized protein from Fusarium oxysporum (strain Fo5176)
37% identity, 94% coverage
An04g03400 uncharacterized protein from Aspergillus niger
38% identity, 94% coverage
SSCH_320003 aldehyde dehydrogenase family protein from Syntrophaceticus schinkii
37% identity, 97% coverage
GYMC52_3134 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase from Geobacillus sp. Y412MC52
37% identity, 94% coverage
A0A0F4THK8 succinate-semialdehyde dehydrogenase [NAD(P)+] (EC 1.2.1.16) from Pseudomonas fluorescens (see paper)
36% identity, 99% coverage
PFLU0180 succinate-semialdehyde dehydrogenase from Pseudomonas fluorescens SBW25
36% identity, 99% coverage
A2QRU8 Aldehyde dehydrogenase from Aspergillus niger (strain ATCC MYA-4892 / CBS 513.88 / FGSC A1513)
An08g07290 aldehyde dehydrogenase aldA-Aspergillus niger from Aspergillus niger
39% identity, 94% coverage
- Integration of enzyme constraints in a genome-scale metabolic model of Aspergillus niger improves phenotype predictions
Zhou, Microbial cell factories 2021 - “...A2R9F2 Acyl-CoA dehydrogenase A2R9F4 Acyl-CoA dehydrogenase A2QI52 Acyl-CoA dehydrogenase A2R800 Acyl-CoA dehydrogenase A2QMT9 Acyl-CoA dehydrogenase A2QRU8 Aldehyde dehydrogenase (NAD+) activity/glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity A2Q8K9 ADP biosynthetic process/AMP metabolic process/GTP metabolic process/ITP metabolic process Enzyme-constrained integration improves the biomass growth rate prediction One of the main...”
- Metabolic engineering with ATP-citrate lyase and nitrogen source supplementation improves itaconic acid production in Aspergillus niger
Hossain, Biotechnology for biofuels 2019 - “...ANI_1_796114 Pyruvate decarboxylase An13g03320 Mito/Cyto 0 0 0.03 0.03 ANI_1_1024074 Aldehyde dehydrogenase ( aldA ) An08g07290 Cyto 143.48 142.19 178.07 177.72 ANI_1_226174 Aldehyde dehydrogenase An10g00850 Per 1.59 1.35 1.69 2.21 ANI_1_1748184 Aldehyde dehydrogenase An04g03400 Cyto 54.25 54.85 53.22 54.15 ANI_1_924184 Acetyl-CoA synthetase ( acuA ) An04g05620...”
- Cytosolic streaming in vegetative mycelium and aerial structures of Aspergillus niger
Bleichrodt, Studies in mycology 2013 - “...An01g00750 1317 Hypothetical protein An01g12550 1292 Strong similarity to mannosyl-oligosaccharide 1,2-alpha-mannosidase msdS - Aspergillus saitoi An08g07290 1262 Aldehyde dehydrogenase aldA - Aspergillus niger An04g08980 1250 Strong similarity to cytoplasmic ribosomal protein of the large subunit L43a - Saccharomyces cerevisiae An18g00500 1204 Strong similarity to obtusifoliol 14-alpha...”
- “...protein nmt1 - Aspergillus parasiticus An08g06960 1206 Strong similarity to histone H3 - Aspergillus nidulans An08g07290 1186 Aldehyde dehydrogenase aldA - Aspergillus niger An03g02400 1166 Strong similarity to spore-wall fungal hydrophobin dewA - Aspergillus nidulans An07g09990 1165 Strong similarity to heat shock protein 70 hsp70 -...”
Marky_1255, WP_013704042 aldehyde dehydrogenase family protein from Marinithermus hydrothermalis DSM 14884
38% identity, 87% coverage
- The quaternary structure of Thermus thermophilus aldehyde dehydrogenase is stabilized by an evolutionary distinct C-terminal arm extension
Hayes, Scientific reports 2018 - “...539 20699 Holophaga foetida DSM 6591 WP_005036551 HolfoDRAFT_1243 537 20356 Marinithermus hydrothermalis DSM 14884 WP_013704042 Marky_1255 533 20349 Meiothermus ruber DSM 1279 WP_013013654 Mrub_1373 529 20350 Meiothermus silvanus DSM 9946 WP_013158503 Mesil_2080 530 21980 Meiothermus timidus DSM 17022 WP_018465841 B047_04905 535 20355 Oceanithermus profundus DSM 14977...”
- “...Deipr_2214 539 20699 Holophaga foetida DSM 6591 WP_005036551 HolfoDRAFT_1243 537 20356 Marinithermus hydrothermalis DSM 14884 WP_013704042 Marky_1255 533 20349 Meiothermus ruber DSM 1279 WP_013013654 Mrub_1373 529 20350 Meiothermus silvanus DSM 9946 WP_013158503 Mesil_2080 530 21980 Meiothermus timidus DSM 17022 WP_018465841 B047_04905 535 20355 Oceanithermus profundus DSM...”
APA386B_1946 aldehyde dehydrogenase from Acetobacter pasteurianus 386B
38% identity, 100% coverage
P41751 Aldehyde dehydrogenase from Aspergillus niger
39% identity, 94% coverage
SAV2613 glycine betaine aldehyde dehydrogenase from Staphylococcus aureus subsp. aureus Mu50
SA2406 glycine betaine aldehyde dehydrogenase gbsA from Staphylococcus aureus subsp. aureus N315
35% identity, 94% coverage
- Additional routes to Staphylococcus aureus daptomycin resistance as revealed by comparative genome sequencing, transcriptional profiling, and phenotypic studies
Song, PloS one 2013 - “...were upregulated including cudT (SAV2615), a likely choline transporter, betA (SAV2612, choline dehydrogenase), and gbsA (SAV2613, glycine betaine aldehyde dehydrogenase). These genes are involved in the uptake and metabolism of choline to produce glycine betaine [59] . Also opuD2 , glycine betaine transporter 2, SAV 2185,...”
- Sulfide Homeostasis and Nitroxyl Intersect via Formation of Reactive Sulfur Species in Staphylococcus aureus
Peng, mSphere 2017 - “...5.4 Gluconate operon repressor + NWMN_2408 SA2300 12.0 Hypothetical; putative transporter protein (glucaronic acid) NWMN_2510 SA2406 6.2 Glycine betaine aldehyde dehydrogenase GbsA NWMN_2513 SA2408 3.7 Putative choline transporter a See Table1 . b At least 2-fold induction with NaHS (see TableS1A; adjusted P value of 0.05)....”
- Myosin-cross-reactive antigen (MCRA) protein from Bifidobacterium breve is a FAD-dependent fatty acid hydratase which has a function in stress protection
Rosberg-Cody, BMC biochemistry 2011 - “...(N315-SA1987, encoding the glycine betaine transporter), proP (N315-SA0531, encoding a proline/betaine transport homolog) and gbsA (SA2406, encoding glycine betaine aldehyde dehydrogenase)) [ 9 ]. The MCRA protein shows over 50% homology with linoleate isomerases from Lactobacillus acidophilus (Genbank: ABB43 157.1) and Lb. reuteri PYR8 linoleate isomerase...”
- Bacteriophage-resistant Staphylococcus aureus mutant confers broad immunity against staphylococcal infection in mice
Capparelli, PloS one 2010 - “...precursor SsaA); SA2206 ( sbi ; IgG-binding protein SBI); SA2255 (oligopeptide transporter substrate binding protein); SA2406 ( gbsA ; glycine betaine aldehyde dehydrogenase gbsA); SA2459 ( ica ; N-glycosyltransferase); SAR216 ( groEL ; chaperonin GROEL); SAR2117 ( groES ; co-chaperonin GRES). ORFs numbers correspond to the...”
- Transcription Profiling of the mgrA Regulon in Staphylococcus aureus
Luong, Journal of bacteriology 2006 - “...SArRNA01 SArRNA01 SA1305 SA1305 SA0573 SA0573 SA2428 SA2428 SA2406 SA2406 SA1997 SA1997 SA0904 SA0904 SA1637 SA1637 SA1090 SA1090 SA1631 Sa1631 SA2147 SA2147...”
- “...encoding a proline/betaine transport homolog), gbsA (SA2406, encoding glycine betaine aldehyde dehydrogenase), cudT (N315-SA2408, encoding the choline...”
- In vivo survival of teicoplanin-resistant Staphylococcus aureus and fitness cost of teicoplanin resistance
McCallum, Antimicrobial agents and chemotherapy 2006 - “...opp-1A F opp-1A R CTTGTACGTAACACGAAAGA TTAACTTGATAGTCACCTCT gbsA (SA2406) gbsA F gbsA R CGTTAGAAGAATCATATGCA AAGTTCCAAGGCAATATTCG icaA (SA2459) icaA F icaA R...”
- “...SA2206 SA2255 sbi opp-1A SA2252 opp-1D SA2405 betA SA2406 gbsA SA2459 icaA SA2460 icaD SA2461 icaB Description and/or putative functionb Fold downregulation...”
- A novel MATE family efflux pump contributes to the reduced susceptibility of laboratory-derived Staphylococcus aureus mutants to tigecycline
McAleese, Antimicrobial agents and chemotherapy 2005 - “...SA0324 SAS016 SA0889 SA1048 SA1203 SA1204 SA1205 SA1898 SA2405 SA2406 SAV0398c a b c uhpT mepR mepA mepB pyrE trpF trpB trpA betA gbsA tet(M) LPXTG protein...”
cymC / O33455 cumic aldehyde dehydrogenase (EC 1.2.1.29) from Pseudomonas putida (see paper)
cymc / AAB62298.1 p-cumic aldehyde dehydrogenase from Pseudomonas putida (see 3 papers)
39% identity, 95% coverage
PfGW456L13_495 Glutarate-semialdehyde dehydrogenase (EC 1.2.1.20) from Pseudomonas fluorescens GW456-L13
36% identity, 99% coverage
- mutant phenotype: Specifically important for utilizing L-Lysine. Automated validation from mutant phenotype: the predicted function (GLUTARATE-SEMIALDEHYDE-DEHYDROGENASE-RXN) was linked to the condition via a MetaCyc pathway. This annotation was also checked manually.
CND02060 Aldehyde dehydrogenase (ALDDH) from Cryptococcus neoformans var. neoformans JEC21
CNBD4300 hypothetical protein from Cryptococcus neoformans var. neoformans B-3501A
37% identity, 95% coverage
LOC4326376 aldehyde dehydrogenase family 2 member C4 from Oryza sativa Japonica Group
39% identity, 92% coverage
- Hub Gene Mining and Co-Expression Network Construction of Low-Temperature Response in Maize of Seedling by WGCNA
Yu, Genes 2023 - “...LOC4326149 isoflavone reductase-like 1 100274353 LOC9269286 uncharacterized 103642911 LOC4346124 exocyst complex component EXO70B1 greenyellow LOC541914 LOC4326376 aldehyde dehydrogenase 5 LOC100502288 LOC4325649 lipid phosphate phosphatase 2 LOC100191783 LOC4349708 carbohydrate transporter/sugar porter/transporter LOC103640644 LOC4352852 thaumatin-like protein LOC100286314 LOC4341938 phosphate import ATP-binding protein pstB 1 LOC100283475 LOC4342022 peptidyl-prolyl cis-trans...”
Saci_1857 aldehyde dehydrogenase from Sulfolobus acidocaldarius DSM 639
36% identity, 96% coverage
AWC34_RS13165 aldehyde dehydrogenase family protein from Staphylococcus equorum
36% identity, 95% coverage
Q6FPK0 Candida glabrata strain CBS138 chromosome J complete sequence from Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)
37% identity, 90% coverage
AL1L1_MOUSE / Q8R0Y6 Cytosolic 10-formyltetrahydrofolate dehydrogenase; 10-FTHFDH; FDH; Aldehyde dehydrogenase family 1 member L1; EC 1.5.1.6 from Mus musculus (Mouse) (see paper)
38% identity, 52% coverage
- function: Cytosolic 10-formyltetrahydrofolate dehydrogenase that catalyzes the NADP(+)-dependent conversion of 10-formyltetrahydrofolate to tetrahydrofolate and carbon dioxide (PubMed:31624291). May also have an NADP(+)-dependent aldehyde dehydrogenase activity towards formaldehyde, acetaldehyde, propionaldehyde, and benzaldehyde (By similarity).
catalytic activity: (6R)-10-formyltetrahydrofolate + H2O + NADP(+) = (6S)-5,6,7,8- tetrahydrofolate + CO2 + H(+) + NADPH (RHEA:10180)
subunit: Homotetramer.
disruption phenotype: Homozygous knockout mice are viable, fertile, develop normally and do not display overt phenotype (PubMed:31624291). However, they have metabolic signs of folate deficiency like the accumulation of formiminoglutamate (PubMed:31624291). Mice show reduced hepatic folate pools with a strong accumulation of (6S)-10- formyltetrahydrofolate and a significant drop in tetrahydrofolate levels (PubMed:31624291). This is associated with a strong decrease of glycine levels as well as levels of several glycine conjugates (PubMed:31624291). - A Murine Model of Maternal Micronutrient Deficiencies and Gut Inflammatory Host-microbe Interactions in the Offspring.
Holani, Cellular and molecular gastroenterology and hepatology 2024 - “...5.12874086820523E-07 8.23675783433759E-04 Up-regulated Q8K3J1 Ndufs8 1.0061373325053900 1.02419070768762E-07 1.65611637433088E-04 Down-regulated Q8QZT1 Acat1 0.571845237423549 2.66429838502315E-06 0.00423889873057183 Down-regulated Q8R0Y6 Aldh1l1 1.173311316002950 3.97439816102578E-07 6.39878103925151E-04 Up-regulated Q91V61 Sfxn3 0.9213072890036610 4.51384641994155E-09 7.33500043240502E-06 Down-regulated Q91VD9 Ndufs1 1.3910446323582500 7.10073967628065E-06 0.011226269428199700 Down-regulated Q91WD5 Ndufs2 1.6323070402188000 1.00580034534228E-05 0.015881587452954600 Down-regulated Q91WT7 Akr1c14 1.1302618764599300 2.57428488310453E-05 0.039849929990458100 Up-regulated Q922Q1...”
- Proteomic profiling of the brain from the wobbler mouse model of amyotrophic lateral sclerosis reveals elevated levels of the astrogliosis marker glial fibrillary acidic protein
Murphy, European journal of translational myology 2023 - “...Q00612 Glucose-6-phosphate 1-dehydrogenase X 2 79.96 0.01139 3.47 Q9WUB3 Glycogen phosphorylase 2 97.04 0.02155 2.55 Q8R0Y6 Cytosolic 10-formyltetrahydrofolate dehydrogenase 2 108.71 0.00524 2.44 P22752 Histone H2A type 1 2 139.57 0.00241 2.21 P03995 Glial fibrillary acidic protein 9 710.27 0.01580 2.21 Q9D0F9 Phosphoglucomutase-1 2 147.84 0.02593...”
- A Detoxification Enzyme for Apis mellifera Newly Characterized by Recombinant Expression: 10-Formyl Tetrahydrofolate Dehydrogenase
Mating, Frontiers in insect science 2022 - “...and Mus musculus amino acid sequences were retrieved from uniprot.org (Accesion Nr: O75891, P28037, Q5RFM9, Q8R0Y6), and predicted amino acid sequences of A. mellifera was retrieved from NCBI (Accesion Nr.: XP_026298140.1). A protein similarity summary was generated based on the DNA sequence of A. mellifera THFDH...”
- Proteomic Identification and Quantification of Snake Venom Biomarkers in Venom and Plasma Extracellular Vesicles
Willard, Toxins 2021 - “...component 1, s subcomponent 2 >100 B2RT14 UDP-glucuronosyltransferase >100 Q01279 Epidermal growth factor receptor >100 Q8R0Y6 Cytosolic 10-formyltetrahydrofolate dehydrogenase >100 P55258 Ras-related protein Rab-8A >100 Q9D1D4 Transmembrane emp24 domain-containing protein 10 >100 Q9QXF8 Glycine N-methyltransferase >100 Q3TNA1 Xylulose kinase >100 Q91YI0 Argininosuccinate lyase >100 Q9R257 Heme-binding...”
- Diminazene Aceturate Stabilizes Atherosclerotic Plaque and Attenuates Hepatic Steatosis in apoE-Knockout Mice by Influencing Macrophages Polarization and Taurine Biosynthesis.
Stachowicz, International journal of molecular sciences 2021 - “...P35492 Hal Histidine ammonia-lyase 1.10 Q9QXF8 Gnmt Glycine N-methyltransferase 1.10 P52840 Sult1a1 Sulfotransferase 1A1 1.11 Q8R0Y6 Aldh1l1 Cytosolic 10-formyltetrahydrofolate dehydrogenase 1.12 P62631 Eef1a2 Elongation factor 1-alpha 2 1.14 O35490 Bhmt Betaine-homocysteine S-methyltransferase 1 1.14 P49429 Hpd 4-hydroxyphenylpyruvate dioxygenase 1.15 O88428 Papss2 Bifunctional 3-phosphoadenosine 5-phosphosulfate synthase 2...”
- The Proteomic Signature of Intestinal Acute Rejection in the Mouse.
Oltean, Metabolites 2021 - “...mitochondrial 0.57 Oxidoreductase Small molecule biochemistry Q9CQ62 Decr 2,4-dienoyl-CoA reductase, mitochondrial 0.54 Oxidoreductase Lipid metabolism Q8R0Y6 Fthfd 10-formyltetrahydrofolate dehydrogenase 0.54 Oxidoreductase Cellular function and maintenance Q9D8W7 Ocad2 OCIA domain-containing protein 2 0.5 Unknown Cancer Q9QWG7 St1b1 Sulfotransferase family cytosolic 1B member 1 0.49 Sulfotransferase Cellular function...”
- Proteomic changes during experimental de- and remyelination in the corpus callosum
Szilagyi, PloS one 2020 - “...ribosomal protein S24 0.830 0.007 0.246 0.593 Q00915 Retinol-binding protein 1 0.622 0.009 0.166 0.431 Q8R0Y6 10-formyltetrahydrofolate dehydrogenase 0.331 0.038 0.164 0.270 Q9D379 Epoxide hydrolase 1 0.904 0.002 0.396 0.430 Q9DCN2 NADH-cytochrome b5 reductase 3 0.714 0.001 0.368 0.343 Q9JJU8 SH3-binding glutamic acid-rich-like protein 0.480 0.036...”
- The impact of postsynaptic density 95 blocking peptide (Tat-NR2B9c) and an iNOS inhibitor (1400W) on proteomic profile of the hippocampus in C57BL/6J mouse model of kainate-induced epileptogenesis.
Tse, Journal of neuroscience research 2019 - “...cortactin P14602 2 43 12.4 3.41E-05 0.011 4.605 KA+1400W VEH HSPB1_MOUSE Heat shock protein beta-1 Q8R0Y6 23 5970 38 4.84E-05 0.0139 1.305 KA+1400W VEH+1400W AL1L1_MOUSE Cytosolic 10-formyltetrahydrofolate dehydrogenase Q02105 3 395 16.3 6.06E-05 0.0156 1.727 KA VEH C1QC_MOUSE Complement C1q subcomponent subunit C Q99L04 7 1495...”
- More
ATEG_05020 aldehyde dehydrogenase from Aspergillus terreus NIH2624
39% identity, 94% coverage
LADH / A3LNE3 NAD(P)+ L-lactaldehyde dehydrogenase from Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (see paper)
38% identity, 95% coverage
FGSG_04194 aldehyde dehydrogenase from Fusarium graminearum PH-1
37% identity, 94% coverage
- Functional Characterization of Aldehyde Dehydrogenase in Fusarium graminearum
Tang, Microorganisms 2023 - “...spore production and weakened the pathogenicity. Furthermore, these deletions altered susceptibility to various abiotic stresses. FGSG_04194 is associated with a number of functions, including mycelial growth and development, stress sensitivity, pathogenicity, toxin production, and energy metabolism. FGSG_00139 and FGSG_11482 are involved in sporulation, pathogenicity, and SDH...”
- “...activity, whereas FGSG_00979 has a positive impact. RNA sequencing and subcellular location analysis revealed that FGSG_04194 is responsible for biological process regulation, including glucose and lipid metabolism. Our results suggest that ALDH contributes to growth, stress responses, pathogenicity, deoxynivalenol synthesis, and mitochondrial energy metabolism in F....”
UW3_RS0109265 NADP-dependent succinate-semialdehyde dehydrogenase from Pseudomonas donghuensis
36% identity, 98% coverage
Entcl_0876 NADP-dependent succinate-semialdehyde dehydrogenase from [Enterobacter] lignolyticus SCF1
37% identity, 99% coverage
- Multi-time series RNA-seq analysis of Enterobacter lignolyticus SCF1 during growth in lignin-amended medium
Orellana, PloS one 2017 - “...Entcl_3805 4-hydroxyphenylacetate 3-monooxygenase (EC 1.14.13.3) 0.000 1.706 -1.529 Entcl_2233 Succinate-semialdehyde dehydrogenase [NADP+] 0.340 1.543 -0.248 Entcl_0876 Succinate-semialdehyde dehydrogenase [NADP+] (EC 1.2.1.16) -1.962 0.231 0.408 Entcl_2810 Gamma-glutamyl-aminobutyraldehyde dehydrogenase (EC 1.2.1.-) -1.292 0.011 0.519 Entcl_2233 Succinate-semialdehyde dehydrogenase [NADP+] 0.340 1.543 -0.248 During the degradation of lignin, many phenolic...”
- “...61 ]. The genome of SCF-1 contains four homologs encoding for this enzyme (Entcl_2233, Entcl_2291, Entcl_0876 and Entcl_2810) and one of them (Entcl_2233) was expressed in higher abundance in lignin-amended cultures. Other genes with a potential role during aromatic metabolism that support lignin degradation were found...”
DV527_RS01175 betaine-aldehyde dehydrogenase from Staphylococcus saprophyticus
36% identity, 94% coverage
7rluA / P28037 Structure of aldh1l1 (10-formyltetrahydrofolate dehydrogenase) in complex with NADP (see paper)
37% identity, 81% coverage
- Ligands: nadp nicotinamide-adenine-dinucleotide phosphate; 4'-phosphopantetheine (7rluA)
XP_011241705 mitochondrial 10-formyltetrahydrofolate dehydrogenase isoform X1 from Mus musculus
38% identity, 59% coverage
AO353_11505 succinate-semialdehyde dehydrogenase (EC 1.2.1.16) from Pseudomonas fluorescens FW300-N2E3
36% identity, 99% coverage
- mutant phenotype: Specifically important for: L-Citrulline; L-Arginine; Putrescine Dihydrochloride. succinate semialdehyde is an intermediate in putrescine catabolism. KEGG has updated its annotation (K00135, see pman:OU5_3276) to include both succinate semialdehyde and glutarate semialdehyde as substrates. The other phenotypes are milder and might indicate a side pathway of conversion of citrulline and arginine to putrescine via ornithine decarboxylase.
LOC101506901, XP_004488550 succinate-semialdehyde dehydrogenase, mitochondrial from Cicer arietinum
37% identity, 90% coverage
- Aldehyde Dehydrogenase 3 Is an Expanded Gene Family with Potential Adaptive Roles in Chickpea
Carmona-Molero, Plants (Basel, Switzerland) 2021 - “...6.72 CaALDH7A1 LOC101513733 Ca1 23,039,421 23,046,624 + XM_012718791 15 XP_012574245 508 54.09 2 5.70 CaALDH5F1 LOC101506901 Ca1 37,645,851 37,658,363 + XM_004488493 20 XP_004488550 530 56.59 1 6.58 CaALDH18B3 LOC101499756 Ca3 8,714,224 8,700,487 - XM_012713409 20 XP_012568863 717 77.75 2 5.96 CaALDH3H3 LOC101515558 Ca4 38,313,842 38,325,387 +...”
- “...XM_012718791 15 XP_012574245 508 54.09 2 5.70 CaALDH5F1 LOC101506901 Ca1 37,645,851 37,658,363 + XM_004488493 20 XP_004488550 530 56.59 1 6.58 CaALDH18B3 LOC101499756 Ca3 8,714,224 8,700,487 - XM_012713409 20 XP_012568863 717 77.75 2 5.96 CaALDH3H3 LOC101515558 Ca4 38,313,842 38,325,387 + XM_004498289 10 XP_004498346 488 53.06 1 8.43...”
NCU00378 aldehyde dehydrogenase from Neurospora crassa OR74A
38% identity, 86% coverage
- L-Carnitine Production Through Biosensor-Guided Construction of the Neurospora crassa Biosynthesis Pathway in Escherichia coli
Kugler, Frontiers in bioengineering and biotechnology 2021 - “...( Franken et al., 2015 ). Both TMABADH.1S and TMABADH.1 are based on the ORF NCU00378; however, TMABADH.1 (549 AA; RefSeq: XP_957264.2) is longer than TMABADH.1S (495 AA; XP_957264.1), which results from a reannotation extending the ORF to a start codon 153 bp upstream. For -BBH,...”
- “...pECXT99A derivatives expressing potential TMABADH from N. crassa . TMABADH.1S and TMABADH.1 were derived from NCU00378, and TMABADH.2 was derived from NCU03415. pECXT99A was used as the empty vector control (EV). Means of three replicates are shown. Error bars were calculated by error analysis from the...”
- Identification and manipulation of Neurospora crassa genes involved in sensitivity to furfural
Feldman, Biotechnology for biofuels 2019 - “...non-preferred carbon sources). In addition, analysis of aldehyde dehydrogenase mutants showed that ahd - 2 (NCU00378) was involved in tolerance to furfural as well as the predicted membrane transporter NCU05580 ( flr - 1 ), a homolog of FLR1 in S. cerevisiae . Further to the...”
- “...using complementing experimental approaches. Based on RNA-seq data analyses, an aldehyde dehydrogenase ahd - 2 (NCU00378) and the transcription factor responsible for carbon catabolite repression, cre - 1 , were identified to be involved in tolerance to furfural. Using a hypothesis-driven approach and based on screening...”
- Characterization of indole-3-pyruvic acid pathway-mediated biosynthesis of auxin in Neurospora crassa
Sardar, PloS one 2018 - “...well as for experimental studies were aro-8 (NCU09116), cfp (NCU02193), cbs-3 (NCU03415), ahd-3 (NCU09648), ahd-2 (NCU00378) and mox-2 (NCU03755). Site-specific binding of enzymes to their respective cofactors is essential to determine their active states. The ligand binding sites for the group of homologous enzymes analyzed in...”
HMPREF0010_01350 NAD-dependent succinate-semialdehyde dehydrogenase from Acinetobacter baumannii ATCC 19606 = CIP 70.34 = JCM 6841
37% identity, 98% coverage
- Delineating the Plausible Molecular Vaccine Candidates and Drug Targets of Multidrug-Resistant Acinetobacter baumannii
Mujawar, Frontiers in cellular and infection microbiology 2019 - “...HMPREF0010_01691 A1S_0561 HMPREF0010_01682 A1S_0571 KFC HMPREF0010_02522 HMPREF0010_02769 HMPREF0010_03233 HMPREF0010_00091 A1S_2232 HMPREF0010_03207 HMPREF0010_01641 HMPREF0010_03022 HMPREF0010_02437 A1S_3280 HMPREF0010_01350 HMPREF0010_01047 Table 6 The human counterparts of the corresponding VaC, ViF, KeF, KFC, and R6 candidates of A. baumannii ATCC19606 strain. Modified String_ID Accession_ID Query coverage Identity VaC AB_01334 NP_858059.1...”
AL1L1_RAT / P28037 Cytosolic 10-formyltetrahydrofolate dehydrogenase; 10-FTHFDH; FDH; Aldehyde dehydrogenase family 1 member L1; FBP-CI; EC 1.5.1.6 from Rattus norvegicus (Rat) (see 7 papers)
P28037 formyltetrahydrofolate dehydrogenase (EC 1.5.1.6) from Rattus norvegicus (see 3 papers)
NP_071992 cytosolic 10-formyltetrahydrofolate dehydrogenase from Rattus norvegicus
37% identity, 52% coverage
- function: Cytosolic 10-formyltetrahydrofolate dehydrogenase that catalyzes the NADP(+)-dependent conversion of 10-formyltetrahydrofolate to tetrahydrofolate and carbon dioxide (PubMed:10585460, PubMed:17302434, PubMed:17884809, PubMed:1848231, PubMed:7822273). May also have an NADP(+)-dependent aldehyde dehydrogenase activity towards formaldehyde, acetaldehyde, propionaldehyde, and benzaldehyde (PubMed:1848231).
catalytic activity: (6R)-10-formyltetrahydrofolate + H2O + NADP(+) = (6S)-5,6,7,8- tetrahydrofolate + CO2 + H(+) + NADPH (RHEA:10180)
subunit: Homotetramer. - A Paternal Methylation Error in the Congenital Hydrocephalic Texas (H-Tx) Rat Is Partially Rescued with Natural Folate Supplements.
Naz, International journal of molecular sciences 2023 - GeneRIF: A Paternal Methylation Error in the Congenital Hydrocephalic Texas (H-Tx) Rat Is Partially Rescued with Natural Folate Supplements.
- Structure of putative tumor suppressor ALDH1L1.
Tsybovsky, Communications biology 2022 - GeneRIF: Structure of putative tumor suppressor ALDH1L1.
- Crystal structures of the carboxyl terminal domain of rat 10-formyltetrahydrofolate dehydrogenase: implications for the catalytic mechanism of aldehyde dehydrogenases.
Tsybovsky, Biochemistry 2007 (PubMed)- GeneRIF: Upon binding of NADP+, side chain of Glu673 is displaced from the active site by the nicotinamide ring & contacts a chain of highly ordered water molecules that may represent a pathway for translocation of the abstracted proton from Glu673 to the solvent.
- The crystal structure of the hydrolase domain of 10-formyltetrahydrofolate dehydrogenase: mechanism of hydrolysis and its interplay with the dehydrogenase domain.
Chumanevich, The Journal of biological chemistry 2004 (PubMed)- GeneRIF: catalytic mechanism for the hydrolase reaction in which Asp-142 polarizes the catalytic water molecule and His-106 orients the carbonyl group of formyl.
- PPAR beta/gamma mediates the antihypertensive activity of a synbiotic preparation of Bifidobacterium lactis and Lactobacillus acidophilus in spontaneous hypertensive rats
Huang, Heliyon 2024 - “...27 2.0893 0.0082 0.9120 0.0814 39 Q63041 Alpha-1-macroglobulin A1M 29 2.0137 0.0147 1.3804 0.0660 40 P28037 Cytosolic 10-formyltetrahydrofolate dehydrogenase AL1L1 24 1.8707 0.0006 1.0471 0.9649 41 P15684 Aminopeptidase N AMPN 41 1.9588 0.0051 1.0765 0.2186 42 P55260 Annexin A4 ANXA4 37 1.4588 0.0339 0.7870 0.9124 43...”
- A Detoxification Enzyme for Apis mellifera Newly Characterized by Recombinant Expression: 10-Formyl Tetrahydrofolate Dehydrogenase
Mating, Frontiers in insect science 2022 - “...abllei , and Mus musculus amino acid sequences were retrieved from uniprot.org (Accesion Nr: O75891, P28037, Q5RFM9, Q8R0Y6), and predicted amino acid sequences of A. mellifera was retrieved from NCBI (Accesion Nr.: XP_026298140.1). A protein similarity summary was generated based on the DNA sequence of A....”
- Hepatoprotective Effect of Grape Seed and Skin Extract Against Lithium Exposure Examined by the Window of Proteomics
Mezni, Dose-response : a publication of International Hormesis Society 2022 - “...1.23 10 6 Creatine kinase (EC 2.7.3.2) chain M ++ + - + + + P28037 Aldh1l1 8.25 10 6 Formyltetrahydrofolate dehydrogenase ++ + + + + ++ P02600 Myl1 6.38 10 9 Myosin light chain 1 ++ + - + + + P00689 Amy2 1.41...”
- “...groups P00564 Ckm Cytoplasm Nucleotide binding, creatine kinase activity, ATP binding, kinase activity, transferase activity P28037 Aldh1l1 Cytoplasm Formyltetrahydrofolate dehydrogenase activity, oxidoreductase activity, aldehydedehydrogenase (NADP+) activity P02600 Myl1 Myosin complex Calcium ion binding P00689 Amy2 Extracellular region Extracellular space, alpha-amylase activity, calcium ion binding, hydrolase activity,...”
- Extracellular vesicles released by steatotic hepatocytes alter adipocyte metabolism
Mleczko, Journal of extracellular biology 2022 - “...1 LPP60_RAT O88202 0.75 4.57E02 60kDa lysophospholipase EF1D_RAT Q68FR9 0.72 4.02E02 Elongation factor 1delta AL1L1_RAT P28037 0.69 6.91E03 Cytosolic 10formyltetrahydrofolate dehydrogenase GCKR_RAT Q07071 0.65 1.03E02 Glucokinase regulatory protein ACACA_RAT P11497 0.63 2.19E02 AcetylCoA carboxylase 1 PH4H_RAT P04176 0.61 4.92E02 Phenylalanine4hydroxylase RS4X_RAT P62703 0.59 3.99E03 40S ribosomal...”
- Gephyrin Interacts with the K-Cl Cotransporter KCC2 to Regulate Its Surface Expression and Function in Cortical Neurons
Al, The Journal of neuroscience : the official journal of the Society for Neuroscience 2022 (secret) - Microglia and astrocytes show limited, acute alterations in morphology and protein expression following a single developmental alcohol exposure.
Lowery, Journal of neuroscience research 2021 - “...1902 (full-length) of rat Aldh1L1(also known as 10-formyltetrahydrofolate dehydrogenase, 10-FTHFDH, FBP-CI and Fthfd, accession number P28037); Mouse: 97% identity (875/902 amino acids identical); Human: 91% identity (823/902 amino acids identical); ~70% identity with Aldh1L2 NeuroMab, Cat: 75140, Lot: 4414BK67, RRID:AB_10673448, Mouse, monoclonal 1:2,000 GFAP Recombinant protein...”
- Identification of hepatic protein-protein interaction targets for betaine homocysteine S-methyltransferase
Garrido, PloS one 2018 - “...c , MS a rat [ 53 ] 10-formyltetrahydrofolate dehydrogenase + carbamoyl phosphate synthetase 1 P28037 P07756 Liver affinity purification and N-terminal sequencing rat [ 54 ] Bardet-Biedl syndrome 1 protein (BBS1) Q8NFJ9 YTH d (fetal kidney library) human [ 55 ] Bardet-Biedl syndrome 2 protein...”
- Functional proteomic analysis of corticosteroid pharmacodynamics in rat liver: Relationship to hepatic stress, signaling, energy regulation, and drug metabolism.
Ayyar, Journal of proteomics 2017 - “...Ces1d Carboxylesterase 1D Metabolism of xenobiotics and of natural substrates; hydrolyzes triacylglycerols and monoacylglycerols UP P28037 Aldh1l1 Cytosolic 10-formyltetrahydrofolate dehydrogenase Folate metabolism - interconversion of tetrahydrofolate molecules UP P07687 Ephx1 Epoxide hydrolase 1, microsomal Hydrolysis of arene and aliphatic epoxides to less reactive and more water...”
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HWX41_RS06485 aldehyde dehydrogenase DhaS from Bacillus paramycoides
38% identity, 95% coverage
- Genomic Analysis of Endophytic Bacillus cereus T4S and Its Plant Growth-Promoting Traits
Adeleke, Plants (Basel, Switzerland) 2021 - “...trp S TryptophantRNA ligase HWX41_RS18055 IAA production, IPA pathway dha S aldehyde dehydrogenase Dha S HWX41_RS06485 dha aldehyde dehydrogenase HWX41_RS25615 dha acetaldehyde dehydrogenase (acetylating) HWX41_RS13995 dha aldehyde dehydrogenase family protein HWX41_RS19325 dha aldehyde dehydrogenase family protein HWX41_RS06850 dha aldehyde dehydrogenase family protein HWX41_RS10480 dha aldehyde dehydrogenase...”
ZP_01726360 aldehyde dehydrogenase from Cyanothece sp. CCY 0110
39% identity, 95% coverage
D3Z6B9 formyltetrahydrofolate dehydrogenase from Mus musculus
38% identity, 58% coverage
AWY96_RS13985 aldehyde dehydrogenase family protein from Serratia plymuthica
38% identity, 95% coverage
- Regulation of indole-3-acetic acid biosynthesis and consequences of auxin production deficiency in Serratia plymuthica
Rico-Jiménez, Microbial biotechnology 2023 - “...of bacterial mutant strains and complementation plasmids Chromosomal mutants defective in ipdc , tyrR , AWY96_RS13985 , AWY96_RS19325 , AWY96_RS21200 and pigP were constructed by homologous recombination using derivate plasmids of pKNG101. These plasmids are listed in Table S2 and were generated by amplifying a 0.60.9kb...”
- “...6.15 AAM AWY96_RS12570 hpaC 4Hydroxyphenylacetate 3monooxygenase, reductase component 3.55 AAM AWY96_RS13795 3Deoxy7phosphoheptulonate synthase 2.25 AAM AWY96_RS13985 Aldehyde dehydrogenase family protein 6.30 AAM AWY96_RS14025 ipdc Indolepyruvate decarboxylase 2.1 Unclassified AWY96_RS21745 4Hydroxybenzoate 3monooxygenase 2.28 XBM AWY96_RS24295 3Oxoacid CoAtransferase subunit A 2.28 XBM AWY96_RS24300 3Oxoacid CoAtransferase subunit B 2.15...”
VDAG_06372 aldehyde dehydrogenase from Verticillium dahliae VdLs.17
38% identity, 93% coverage
- Hypothetical Protein VDAG_07742 Is Required for Verticillium dahliae Pathogenicity in Potato
Wang, International journal of molecular sciences 2023 - “...VDAG_08496 VDAG_09536 VDAG_08929 VDAG_05344 10.37 11.3 Map00350 Tyrosine metabolism VDAG_04798 VDAG_03345 VDAG_07316 VDAG_07507 VDAG_07314 VDAG_07369 VDAG_06372 7.04 4.49 Map00600 Sphingolipid metabolism VDAG_05015 VDAG_05347 VDAG_01556 VDAG_07821 10.23 3.41 Map00561 Glycerolipid metabolism VDAG_09648 VDAG_04951 VDAG_09741 VDAG_02013 VDAG_07738 7.04 3.31 Map00010 Glycolysis/Gluconeogenesis VDAG_07446 VDAG_07507 VDAG_09741 VDAG_02013 VDAG_07057 VDAG_06372 4.33...”
FOXG_00928 aldehyde dehydrogenase from Fusarium oxysporum f. sp. lycopersici 4287
38% identity, 95% coverage
- Gene Regulatory Network Inference and Gene Module Regulating Virulence in Fusarium oxysporum
Cano, Frontiers in microbiology 2022 - “...FOXG_01037 (0.11987755) FOXG_02500 (0.00537207) FOXG_01037 (0.0009947) FOXG_01626 (0.0498954) 4 FOXG_04255 (0.0987459) FOXG_12790 (0.00530916) FOXG_05265 (0.0009814) FOXG_00928 (0.0498882) 5 FOXG_05265 (0.09045126) FOXG_03680 (0.0052953) FOXG_04255 (0.0009301) FOXG_12790 (0.04926705) * Between parentheses, the value of centrality of each gene is added, the higher the value, the more important the...”
CNAG_01078 aldehyde dehydrogenase (NAD) from Cryptococcus neoformans var. grubii H99
37% identity, 95% coverage
Q9CZS1 aldehyde dehydrogenase (NAD+) (EC 1.2.1.3) from Mus musculus (see 2 papers)
NP_082546 aldehyde dehydrogenase X, mitochondrial precursor from Mus musculus
39% identity, 91% coverage
- Branched-Chain Amino Acid Degradation Pathway was Inactivated in Colorectal Cancer: Results from a Proteomics Study
Lian, Journal of Cancer 2024 - “...0.99 Yes Q8QZT1 Acat1 Acetyl-CoA acetyltransferase, mitochondrial 17.45 9 1 0.63 0.62 Down 0.91 Yes Q9CZS1 Aldh1b1 Aldehyde dehydrogenase X, mitochondrial 27.17 14 1.04 0.33 0.44 Down 0.23 Yes * 'Yes' indicates a relationship between protein expression and the overall survival rate of cancer patients in...”
- Proteomic Analysis of Protective Effects of Dl-3-n-Butylphthalide against mpp + -Induced Toxicity via downregulating P53 pathway in N2A Cells
Zhao, Proteome science 2023 - “...mitochondrial \"" 0.032273 Q9D0M2 Cdca7 Cell division cycle-associated protein 7 0.049852 Q9D0A3 Arpin Arpin 0.001291 Q9CZS1 Aldh1b1 \Aldehyde dehydrogenase X, mitochondrial \"" 0.001256 Q9CZC8 Scrn1 Secernin-1 0.027164 Q9CYL5 Glipr2 Golgi-associated plant pathogenesis-related protein 1 0.002113 Q9CY64 Blvra Biliverdin reductase A 0.000413 Q9CY50 Ssr1 Translocon-associated protein subunit...”
- Decreased Klotho Expression Causes Accelerated Decline of Male Fecundity through Oxidative Injury in Murine Testis.
Wang, Antioxidants (Basel, Switzerland) 2023 - “...Q5M9K1; P07309; Q9D6A4 Aldh1a1 Retinal dehydrogenase 1 1.110 P24549 Aldh1b1 Aldehyde dehydrogenase X, mitochondrial 0.844 Q9CZS1 Tpi1 Triosephosphate isomerase 0.679 P17751; P17751-2; H7BXC3 Aldh2 Aldehyde dehydrogenase, mitochondrial 0.610 Q544B1; Q3UJW1; Q3U9J7; P47738; A0A0G2JEU1; Q3U6I3; Q3TVM2 MCODE_4 PPAR signaling pathway Fabp3 Fatty acid-binding protein, heart 2.254 Q5EBJ0;...”
- Proteomic analysis reveals activation of platelet- and fibrosis-related pathways in hearts of ApoE-/- mice exposed to diesel exhaust particles.
Jung, Scientific reports 2023 - “...CLTC Clathrin heavy chain 1 1.31 0.035 P22437 PTGS1 Prostaglandin G/H synthase 1 1.31 0.017 Q9CZS1 ALDH1B1 Aldehyde dehydrogenase X, mitochondrial 1.31 0.049 Q8C1D8 IWS1 Protein IWS1 homolog 1.30 0.027 P32261 SERPINC1 Antithrombin-III 1.30 0.045 Pathway analysis of differentially expressed proteins in hearts of DEP-exposed ApoE...”
- ISG15 Is a Novel Regulator of Lipid Metabolism during Vaccinia Virus Infection.
Albert, Microbiology spectrum 2022 - “...Q8CAY6 Acat2 Acetyl-CoA acetyltransferase, cytosolic 2.61 P97742 Cpt1a Carnitine O -palmitoyltransferase 1, liver isoform 5.88 Q9CZS1 Aldh1b1 Aldehyde dehydrogenase X, mitochondrial 6.21 P32020 Scp2 Sterol carrier protein 2 6.86 Lipid synthesis O35083 Agpat1 1-Acyl- sn -glycerol-3-phosphate acyltransferase alpha 4.95 Q9D517 Agpat3 1-Acyl- sn -glycerol-3-phosphate acyltransferase gamma...”
- The Proteomic Signature of Intestinal Acute Rejection in the Mouse.
Oltean, Metabolites 2021 - “...Oxidoreductase, Transferase Oxidative stress Q8K0C9 Gmds GDP-mannose 4,6 dehydratase 0.57 Lyase Cellular function and maintenance Q9CZS1 Al1b1 Aldehyde dehydrogenase X, mitochondrial 0.57 Oxidoreductase Small molecule biochemistry Q9CQ62 Decr 2,4-dienoyl-CoA reductase, mitochondrial 0.54 Oxidoreductase Lipid metabolism Q8R0Y6 Fthfd 10-formyltetrahydrofolate dehydrogenase 0.54 Oxidoreductase Cellular function and maintenance Q9D8W7...”
- Modulation of Proteome Profile in AβPP/PS1 Mice Hippocampus, Medial Prefrontal Cortex, and Striatum by Palm Oil Derived Tocotrienol-Rich Fraction
Hamezah, Journal of Alzheimer's disease : JAD 2019 - “...subunit B, brain isoform ATP6V1B2 Q61753 D-3-phosphoglycerate dehydrogenase PHGDH Q9Z1B3 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 PLCB1 Q9CZS1 Aldehyde dehydrogenase X ALDH1B1 Q91WD5 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2 NDUFS2 Q7TMF3 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 Q91YQ5 Dolichyl-diphosphooligosaccharideprotein glycosyltransferase subunit 1 RPN1 P00397 Cytochrome...”
- “...Creatine kinase U-type CKMT1 Striatum Glycerolipid metabolism 2 0.0027 0.0275 Q9JII6 Alcohol dehydrogenase [NADP(+)] AKR1A1 Q9CZS1 Aldehyde dehydrogenase X ALDH1B1 Glycolysis/Gluconeogenesis 2 0.0035 0.0290 Q9JII6 Alcohol dehydrogenase [NADP(+)] AKR1A1 Q9CZS1 Aldehyde dehydrogenase X ALDH1B1 Proteasome 2 0.0016 0.0265 Q9WVJ2 26S proteasome non-ATPase regulatory subunit 13 PSMD13...”
- Dgat1 and Dgat2 regulate enterocyte triacylglycerol distribution and alter proteins associated with cytoplasmic lipid droplets in response to dietary fat.
Hung, Biochimica et biophysica acta. Molecular and cell biology of lipids 2017 - “...Carbonyl reductase [NADPH] 1 Cbr1 P48758 Carbohydrate Metabolism Dgat2 Int Aldehyde dehydrogenase X, mitochondrial Aldh1b1 Q9CZS1 Carbohydrate Metabolism Cytochrome c oxidase subunit 2 Mtco2 P00405 Carbohydrate Metabolism Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit Ddost O54734 Carbohydrate Metabolism Ornithine aminotransferase, mitochondrial Oat P29758 Carbohydrate Metabolism Ces2g E9PV38 Hydrolase...”
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- The aldehyde dehydrogenase ALDH1B1 exerts antiviral effects through the aggregation of the adaptor MAVS.
Sun, Science signaling 2024 (PubMed)- GeneRIF: The aldehyde dehydrogenase ALDH1B1 exerts antiviral effects through the aggregation of the adaptor MAVS.
- Acetaldehyde and defective mismatch repair increase colonic tumours in a Lynch syndrome model with Aldh1b1 inactivation.
Cerretelli, Disease models & mechanisms 2023 - GeneRIF: Acetaldehyde and defective mismatch repair increase colonic tumours in a Lynch syndrome model with Aldh1b1 inactivation.
- Protein Methyltransferase Inhibition Decreases Endocrine Specification Through the Upregulation of Aldh1b1 Expression.
Giannios, Stem cells (Dayton, Ohio) 2019 - GeneRIF: We identified AMI-5, a protein methyltransferase inhibitor, as an Aldh1b1 inducer and showed that it can maintain Aldh1b1 expression in embryonic pancreas explants. This led to a selective reduction in endocrine specification. This effect was due to a downregulation of Ngn3, and it was mediated through Aldh1b1 since the effect was abolished in Aldh1b1 null pancreata.
- Aldh1b1 expression defines progenitor cells in the adult pancreas and is required for Kras-induced pancreatic cancer.
Mameishvili, Proceedings of the National Academy of Sciences of the United States of America 2019 - GeneRIF: Overexpression of Aldh1b1 is associated with pancreatic cancer development.
- Aldehyde dehydrogenase activity is necessary for beta cell development and functionality in mice.
Anastasiou, Diabetologia 2016 - GeneRIF: Aldehyde dehydrogenase has a critical role for beta cell development and functionality in mice
- ALDH1B1 links alcohol consumption and diabetes.
Singh, Biochemical and biophysical research communications 2015 - GeneRIF: show for the first time the functional in vivo role of ALDH1B1 in acetaldehyde metabolism and in maintaining glucose homeostasis
- ALDH1B1 is a potential stem/progenitor marker for multiple pancreas progenitor pools.
Ioannou, Developmental biology 2013 - GeneRIF: ALDH1B1 is a potential stem/progenitor marker for multiple pancreas progenitor pools
- Transcriptome profiling of selectively bred Pacific oyster Crassostrea gigas families that differ in tolerance of heat shock
Lang, Marine biotechnology (New York, N.Y.) 2009 - “...BQ426907 C 1.E-02 Arginase Equus caballus XP_001503335 8.E-58 BQ426918 B 3.E-02 Aldehyde dehydrogenase Mus musculis NP_082546 3.E-42 BQ426932 B 1.E-04 Diaphorase 1 Xenopus laevis NP_001080477 2.E-84 BQ427069 NA 2.E-03 Alcohol dehydrogenase Lysiphlebus testaceipes AAY63990 6.E-104 CD526814 F 8.E-15 Senescence associated Brugia malayi EDP31077 2.E-55 CD526816 F...”
PGTG_15008 aldehyde dehydrogenase (NAD+) from Puccinia graminis f. sp. tritici CRL 75-36-700-3
39% identity, 94% coverage
AL1L2_MOUSE / Q8K009 Mitochondrial 10-formyltetrahydrofolate dehydrogenase; Mitochondrial 10-FTHFDH; mtFDH; Aldehyde dehydrogenase family 1 member L2; EC 1.5.1.6 from Mus musculus (Mouse) (see paper)
38% identity, 51% coverage
- function: Mitochondrial 10-formyltetrahydrofolate dehydrogenase that catalyzes the NADP(+)-dependent conversion of 10-formyltetrahydrofolate to tetrahydrofolate and carbon dioxide.
catalytic activity: (6R)-10-formyltetrahydrofolate + H2O + NADP(+) = (6S)-5,6,7,8- tetrahydrofolate + CO2 + H(+) + NADPH (RHEA:10180)
disruption phenotype: Homozygous knockout mice lacking Aldh1l2 are viable and fertile and no embryonic lethality is observed (PubMed:33168096). They do not display phenotypic differences in terms of growth, food consumption and development (PubMed:33168096). 10- formyl-THF and dihydrofolate accumulate in the liver of the knockout mice. It is associated with a decrease in levels of NADPH and ATP specifically in the mitochondrion (PubMed:33168096). Male knockout mice accumulate more fats in the liver which is associated with impaired beta-oxidation of fatty acids (PubMed:33168096). - Lectin-Based Immunophenotyping and Whole Proteomic Profiling of CT-26 Colon Carcinoma Murine Model.
Faragó, International journal of molecular sciences 2024 - “...Q9R1Q7 Proteolipid protein 2 68.83 P16110 Galectin-3 73.50 P97310 DNA replication licensing factor MCM2 81.89 Q8K009 Mitochondrial 10-formyltetrahydrofolate dehydrogenase 82.70 Q61753 D-3-phosphoglycerate dehydrogenase 100 P25206 DNA replication licensing factor MCM3 100 P52927 High mobility group protein HMGI-C 100 P14069 Protein S100-A6 100 P70202 Latexin 100 Q64437...”
- miR-29a/b1 Regulates the Luteinizing Hormone Secretion and Affects Mouse Ovulation
Guo, Frontiers in endocrinology 2021 - “...0.79 Q64674 Srm Spermidine synthase OS=Mus musculus GN=Srm PE=1 SV=1 34 kDa < 0.0001 0.79 Q8K009 Aldh1l2 Mitochondrial 10-formyltetrahydrofolate dehydrogenase OS=Mus musculus GN=Aldh1l2 PE=1 SV=2 102 kDa < 0.0001 0.79 Q8R1U2 Cgref1 Cell growth regulator with EF hand domain protein 1 OS=Mus musculus GN=Cgref1 PE=1 SV=1...”
- Preclinical Development of FA5, a Novel AMP-Activated Protein Kinase (AMPK) Activator as an Innovative Drug for the Management of Bowel Inflammation
Antonioli, International journal of molecular sciences 2021 - “...3.7 538/a P58252 Elongation factor 2 Eef2 33 27 95,314 6.41 6.8 0.001 6.8 549 Q8K009 Mitochondrial 10-formyltetrahydrofolate dehydrogen Aldh1l2 32 24 101,590 5.93 7.2 0.03 7.2 594 P61979 Heterogeneous nuclear ribonucleoprotein K Hnrnpk 5 2 50,976 5.39 0.15 0.000086 6.5 652 Q61881 DNA replication licensing...”
- Functional proteomic analysis of corticosteroid pharmacodynamics in rat liver: Relationship to hepatic stress, signaling, energy regulation, and drug metabolism.
Ayyar, Journal of proteomics 2017 - “...Aldh1b1 Aldehyde dehydrogenase 1B1, mitochondrial Ethanol degradation - transformation from acetaldehyde to acetic acid UP Q8K009 Aldh1l2 Aldehyde dehydrogenase 1L2, mitochondrial Formate oxidation (homolog of 10-formyltetrahydrofolate dehydrogenase) UP Q9JLJ3 Aldh9a1 Aldehyde dehydrogenase 9A1 Carnitine biosynthesis UP P13601 Aldh1a7 Aldehyde dehydrogenase 1A7, cytosolic Oxidizes benzaldehyde, propionaldehyde and...”
- Cardiac metabolic pathways affected in the mouse model of barth syndrome
Huang, PloS one 2015 - “...) Q8CGK3 >99 2.77 Degradation of misfolded, polypeptides. Chaperone activity 37 Mitochondrial 10-formyltetrahydrofolate dehydrogenase Aldh1l2 Q8K009 100 2.31 Tetrahydrofolate / One carbon metabolism 76 Mitochondrial 10-formyltetrahydrofolate dehydrogenase Aldh1l2 Q8K009 100 2.60 Tetrahydrofolate / One carbon metabolism 5 Bifunctional methylenetetrahydrofolate dehydrogenase Mthfd2 ( * ) P18155 100...”
davD / Q9I6M5 glutarate semialdehyde dehydrogenase (EC 1.2.1.20) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 2 papers)
DAVD_PSEAE / Q9I6M5 Glutarate-semialdehyde dehydrogenase; EC 1.2.1.- from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
PA0265 succinate-semialdehyde dehydrogenase from Pseudomonas aeruginosa PAO1
36% identity, 99% coverage
- function: Catalyzes the conversion of 5-oxopentanoate (glutarate semialdehyde) to glutarate. Involved in L-lysine degradation.
catalytic activity: 5-oxopentanoate + H2O + NADP(+) = glutarate + 2 H(+) + NADPH (RHEA:57832) - Polyamine and Ethanolamine Metabolism in Bacteria as an Important Component of Nitrogen Assimilation for Survival and Pathogenicity
Krysenko, Medical sciences (Basel, Switzerland) 2022 - “...gabT-like or puuE-like GabT (b2662)/PuuE (b1302) GabT (PA266) SCO5676 Succinate-semialdehyde dehydrogenase gabD-like GabD (b2661) GabD (PA0265) SCO5679 Amino acids/polyamine permease PuuP (b1296) PA5510/PAO322 SCO5977 Hydrolase - - SCO6960 Amidohydrolase - - SCO6961 -glutamyl-polyamine synthetase PuuA (b1297) PauA7 (PA5508)/SpuI (PA0296) SCO6962 medsci-10-00040-t002_Table 2 Table 2 Combined list...”
- Transcription Inhibitors with XRE DNA-Binding and Cupin Signal-Sensing Domains Drive Metabolic Diversification in Pseudomonas
Trouillon, mSystems 2021 - “...( PA4450 ) (D), PA4987 and PA4985 - PA4986 (E), and PauR and davD ( PA0265 ), PA1541 (by RT-qPCR), and PA2776 (by EMSA) (F). (Upper left panels) Local RNA-seq read abundance fold changes in the corresponding mutants compared to parental strain. Red lines show the...”
- Differential transcription profiling of the phage LUZ19 infection process in different growth media
Brandão, RNA biology 2021 (secret) - Proteome profiling of Pseudomonas aeruginosa PAO1 identifies novel responders to copper stress
Wright, BMC microbiology 2019 - “...Class 4 PA5562 1.9 0.002 5 Chromosome partitioning protein Spo0J Cytoplasmic [Class 3] Class 2 PA0265 2.0 0.004 3 Succinate-semialdehyde dehydrogenase Cytoplasmic [Class 3] Class 2 PA5554 2.0 <0.0001 15 ATP synthase beta chain Cytoplasmic [Class 3]; Outer Membrane Vesicle [Class 1] Class 2 PA2259 2.1...”
- Reconciling high-throughput gene essentiality data with metabolic network reconstructions
Blazier, PLoS computational biology 2019 - “...and in vitro identified consensus nonessential genes for PAO1. PAO1 Locus Tag Name Function Subsystem PA0265 davD Glutaric semialdehyde dehydrogenase Carbohydrate PA0546 metK Methionine adenosyltransferase Amino Acid PA0581 ygiH Glycerol-3-phosphate acyltransferase Lipid PA1758 pabB Para-aminobenzoate synthase component I Cofactors and Vitamins PA1806 fabI NADH-dependent enoyl-ACP reductase...”
- Modulation of Type III Secretion System in Pseudomonas aeruginosa: Involvement of the PA4857 Gene Product
Zhu, Frontiers in microbiology 2016 - “...PA2621 ( clpS ) 2964732 ATP-dependent Clp protease adaptor 7.2 PA3284 3676853 Hypothetical protein 6.0 PA0265 ( gabD ) 300415 Succinate-semialdehyde dehydrogenase -6.5 PA1056 ( shaC ) 1146026 Proton transport -4.0 PA1703 ( pcrD ) 1850681 Type III secretory apparatus protein -7.0 PA1713 ( exsA )...”
- “...of the master regulator ExsA, and regulates T3SS expression ( Liang et al., 2014 ). PA0265 ( gabD ) and PA2550 are involved in amino acid metabolism, while NuoL and ShaC are associated with energy metabolism. These results are consistent with previous studies showing that metabolic...”
- Functional characterization of seven γ-Glutamylpolyamine synthetase genes and the bauRABCD locus for polyamine and β-Alanine utilization in Pseudomonas aeruginosa PAO1
Yao, Journal of bacteriology 2011 - “...function -Alanine:pyruvate transaminase Transcriptional regulator; LysR family PA0265 PA0266 gabD gabT 448 721 6,923 9,244 4,434 6,136 Succinate semialdehyde...”
- The development of ciprofloxacin resistance in Pseudomonas aeruginosa involves multiple response stages and multiple proteins
Su, Antimicrobial agents and chemotherapy 2010 - “...identified by mass spectrometry as PA0265 (succinate-semialdehyde dehydrogenase [SSADH], encoded by gabD) and PA3570 (methylmalonate-semialdehyde dehydroge-...”
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- Modified N-acyl-L-homoserine lactone compounds abrogate Las-dependent quorum-sensing response in human pathogen Pseudomonas aeruginosa
Ballante, Frontiers in molecular biosciences 2023 - “...Yes Protein hcp1 hcp1 Q9I747 17 1.6 0.0037 X X Secreted Yes Glutarate-semialdehyde dehydrogenase davD Q9I6M5 52 1.5 0.0043 X Cytosol Yes Flagellar hook-associated protein type 3 FlgL flgL Q9I4P2 47 1.2 0.0059 X X X X Secreted Yes Extracellular DNA degradation protein EddB eddB Q9HXA4...”
LOC541914, NP_001105047 aldehyde dehydrogenase 5 from Zea mays
Q8S529 Aldehyde dehydrogenase5 from Zea mays
40% identity, 91% coverage
- Hub Gene Mining and Co-Expression Network Construction of Low-Temperature Response in Maize of Seedling by WGCNA
Yu, Genes 2023 - “...LOC542717 LOC4326149 isoflavone reductase-like 1 100274353 LOC9269286 uncharacterized 103642911 LOC4346124 exocyst complex component EXO70B1 greenyellow LOC541914 LOC4326376 aldehyde dehydrogenase 5 LOC100502288 LOC4325649 lipid phosphate phosphatase 2 LOC100191783 LOC4349708 carbohydrate transporter/sugar porter/transporter LOC103640644 LOC4352852 thaumatin-like protein LOC100286314 LOC4341938 phosphate import ATP-binding protein pstB 1 LOC100283475 LOC4342022 peptidyl-prolyl...”
- Janus-Faced Nature of Light in the Cold Acclimation Processes of Maize
Szalai, Frontiers in plant science 2018 - “...ACG28932 Glycosyltransferase 2.375742 0.002720237 ONM02814 Glycerophosphodiester phosphodiesterase GDPDL3 2.1040068 4.56E-04 ONM60638 Alpha-galactosidase 3 1.4812617 0.002564861 NP_001105047 Aldehyde dehydrogenase 5 2.2098408 0.001409359 ONM10264 Plastidial pyruvate kinase 1 chloroplastic 1.807035 2.80E-04 AQK87666 Trehalose-6-phosphate synthase12 1.4775023 1.85E-04 ONM30490 Glycosyltransferase family 61 protein 2.2052014 0.001584862 NP_001148138 Glycerol 3-phosphate permease 1.7980256...”
- A new and unified nomenclature for male fertility restorer (RF) proteins in higher plants
Kotchoni, PloS one 2010 - “...PS00687PS00070 ALDH Zea mays RF1B2 RF2C AF348413 Q8S531 PS00687PS00070 ALDH Zea mays RF1B3 RF2D BT041044 Q8S529 PS00687PS00070 ALDH Zea mays Family 2 RF2A1 RF1B DQ311054 Q2PPE6 PS51375 PPR repeat Oryza sativa RF2B1 RF1A DQ311052 Q2PPE8 PS51375 PPR repeat Oryza sativa RF2B2 RF1 AB106867 Q76C99 PS51375 PPR...”
BAS3348 aldehyde dehydrogenase from Bacillus anthracis str. Sterne
BA3609 aldehyde dehydrogenase from Bacillus anthracis str. Ames
GBAA3609 aldehyde dehydrogenase from Bacillus anthracis str. 'Ames Ancestor'
38% identity, 95% coverage
- Ser/Thr protein kinase PrkC-mediated regulation of GroEL is critical for biofilm formation in Bacillus anthracis
Arora, NPJ biofilms and microbiomes 2017 - “...50.5% Superoxide dismutase Bas5300 105 60.3% GroEL, 60kDa chaperone Bas0253 97 44.1 % Aldehyde dehydrogenase Bas3348 113 54.5% 1-Pyrroline-5-carboxylate dehydrogenase Bas0295 197 52.0% Formate acetyltransferase Bas0481 94 42.3% Alcohol dehydrogenase Bas2111 144 59.7% Table 3 Phospho-enriched proteins in Bas -wt identified by mass spectrometry Protein identified...”
- Identification of CodY targets in Bacillus anthracis by genome-wide in vitro binding analysis
Château, Journal of bacteriology 2013 - “...Upstream Upstream Upstream BAS3072 BAS3079* BAS3228 BAS3315* BAS3348 BAS3379 BAS3408 BAS3421 BAS3424 BAS3443 (hutP) BAS3682 (xerC) BAS3682 (xerC) BAS3850...”
- Identification of in vivo-expressed immunogenic proteins by serological proteome analysis of the Bacillus anthracis secretome
Chitlaru, Infection and immunity 2007 - “...BA2673 BA2944 BA2947 BA3189 BA3338 BA3346 BA3367 BA3588 BA3609 BA3645 BA3660 BA3737 BA4322 BA4346 BA4387 BA4539 BA4705 BA4750 BA4873 BA5220 BA5364 BA5427 BA5470...”
- “...the membranal fraction are BA0108, BA0309, BA1129, BA1818, BA2346, BA3609, BA4705, and BA5576. f The numbers are the numbers assigned to the protein spots on...”
- Genome-based bioinformatic selection of chromosomal Bacillus anthracis putative vaccine candidates coupled with proteomic identification of surface-associated antigens
Ariel, Infection and immunity 2003 - “...protein S-layer protein Aldehyde dehydrogenase (BA3609, gi21401476) Methylcitrate dehydratase (BA2349, gi21400220) Hydroxyperoxide reductase Novel SLH...”
- Identification of Bacillus anthracis spore component antigens conserved across diverse Bacillus cereus sensu lato strains
Mukhopadhyay, Molecular & cellular proteomics : MCP 2009 - “...GBAA4157 GBAA0887 GBAA3944 GBAA4843 GBAA5583 GBAA0309 GBAA3609 GBAA4184 GBAA0252 GBAA5222 GBAA4539 GBAA0267 GBAA0108 GBAA0107 gi47528887 gi47526368 gi47528961...”
- “...GBAA4157 GBAA0887 GBAA3944 GBAA4843 GBAA5583 GBAA0309 GBAA3609 GBAA4184 GBAA0252 GBAA5222 Accession no. gi47528887 gi47526368 gi47528961 gi47525306 gi47529455...”
BC3555 Aldehyde dehydrogenase from Bacillus cereus ATCC 14579
37% identity, 95% coverage
G3V7I5 Aldehyde dehydrogenase X, mitochondrial from Rattus norvegicus
39% identity, 91% coverage
- [Quantitative analysis of differential proteins in renal tissues of rats with chronic intermittent hypoxic exposure based on TMT and PRM technology].
Wei, Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2023 - The mitochondrial proteomic changes of rat hippocampus induced by 28-day simulated microgravity.
Ji, PloS one 2022 - “...MACROD1 1.61 0.018189 IDH3B_RAT Q68FX0 Idh3B Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial 1.60 0.002549 G3V7I5_RAT G3V7I5 Aldh1b1 Aldehyde dehydrogenase X, mitochondrial 1.60 0.006674 D3ZKG1_RAT D3ZKG1 Mmut Methylmalonyl CoA mutase 1.60 0.015932 F210A_RAT Q5XIJ4 Fam210a Protein FAM210A 1.60 0.013908 FMT_RAT Q5I0C5 Mtfmt Methionyl-tRNA formyltransferase, mitochondrial 1.60 0.018123...”
- Fluoxetine Enhances Synaptic Vesicle Trafficking and Energy Metabolism in the Hippocampus of Socially Isolated Rats.
Filipović, International journal of molecular sciences 2022 - “...29 21 Adenylyl cyclase-associated protein 2 P52481 Cap2 1.67 7 5 Aldehyde dehydrogenase X, mitochondrial G3V7I5 Aldh1b1 1.66 7 5 Oxidation resistance protein 1 A0A0G2K7Y2 Oxr1 1.64 6 5 Protein NDRG2 Q8VBU2 Ndrg2 1.64 9 9 Spectrin beta chain A0A0G2K8W9 Sptbn1 1.64 23 19 Amine oxidase...”
- iTRAQ-based quantitative proteomics analysis of the hepatoprotective effect of melatonin on ANIT-induced cholestasis in rats.
Wang, Experimental and therapeutic medicine 2021 - “...carrier protein 2 (SCP2) 2.0842 0.0795 G3V6I4 Mitochondrial amidoxime reducing component 1 (MARC1) 1.5733 0.1288 G3V7I5 Aldehyde dehydrogenase 1 family, member B1 (ALDH1A1) 3.5411 0.0442 G3V7J0 Aldehyde dehydrogenase 6 family, member A1 (ALDH6A1) 1.5926 0.0348 G3V836 Clusterin (CLU) 0.6256 0.0209 M0R4N4 Dehydrogenase/reductase (SDR family) member 7...”
- iTRAQ-based proteomics profiling of Schwann cells before and after peripheral nerve injury.
Shi, Iranian journal of basic medical sciences 2018 - “...G3V824 Insulin-like growth factor 2 receptor 8.57422E-17 1.552795031 GFPT2 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 5.26705E-09 1.547987616 G3V7I5 Aldehyde dehydrogenase X, mitochondrial 2.6707E-10 1.545595054 Q6AY48 Poly(RC) binding protein 3 4.40202E-09 1.545595054 NDRG1 Protein NDRG1 2.77589E-13 1.543209877 A0A0G2K9I6 Ceruloplasmin 2.93992E-08 1.543209877 BACD3 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation...”
P30837 aldehyde dehydrogenase (NAD+) (EC 1.2.1.3) from Homo sapiens (see 2 papers)
NP_000683 aldehyde dehydrogenase X, mitochondrial precursor from Homo sapiens
38% identity, 91% coverage
- Multi-omics profiling reveals cellular pathways and functions regulated by ALDH1B1 in colon cancer cells.
Wang, Chemico-biological interactions 2023 - GeneRIF: Multi-omics profiling reveals cellular pathways and functions regulated by ALDH1B1 in colon cancer cells.
- Targeting colorectal cancer with small-molecule inhibitors of ALDH1B1.
Feng, Nature chemical biology 2022 - GeneRIF: Targeting colorectal cancer with small-molecule inhibitors of ALDH1B1.
- Aldehyde Dehydrogenase 1B1 Is Implicated in DNA Damage Response in Human Colorectal Adenocarcinoma.
Tsochantaridis, Cells 2022 - GeneRIF: Aldehyde Dehydrogenase 1B1 Is Implicated in DNA Damage Response in Human Colorectal Adenocarcinoma.
- Aldehyde dehydrogenase 1B1 is a potential marker of colorectal tumors.
Wang, Histology and histopathology 2021 (PubMed)- GeneRIF: Aldehyde dehydrogenase 1B1 is a potential marker of colorectal tumors.
- AMBRA1 Negatively Regulates the Function of ALDH1B1, a Cancer Stem Cell Marker, by Controlling Its Ubiquitination.
Baek, International journal of molecular sciences 2021 - GeneRIF: AMBRA1 Negatively Regulates the Function of ALDH1B1, a Cancer Stem Cell Marker, by Controlling Its Ubiquitination.
- Role of aldehyde dehydrogenases, alcohol dehydrogenase 1B genotype, alcohol consumption, and their combination in breast cancer in East-Asian women.
Park, Scientific reports 2020 - GeneRIF: Role of aldehyde dehydrogenases, alcohol dehydrogenase 1B genotype, alcohol consumption, and their combination in breast cancer in East-Asian women.
- Protein Methyltransferase Inhibition Decreases Endocrine Specification Through the Upregulation of Aldh1b1 Expression.
Giannios, Stem cells (Dayton, Ohio) 2019 - GeneRIF: We identified AMI-5, a protein methyltransferase inhibitor, as an Aldh1b1 inducer and showed that it can maintain Aldh1b1 expression in embryonic pancreas explants. This led to a selective reduction in endocrine specification. This effect was due to a downregulation of Ngn3, and it was mediated through Aldh1b1 since the effect was abolished in Aldh1b1 null pancreata.
- Genetic variants in ALDH1B1 and alcohol dependence risk in a British and Irish population: A bioinformatic and genetic study.
Way, PloS one 2017 - GeneRIF: The aims of this study were: (i) to use bioinformatic techniques to characterize the possible effects of selected variants in ALDH1B1 on protein structure and function; and, (ii) to genotype three missense and one stop-gain, protein-altering, non-synonymous single nucleotide polymorphisms in 1478 alcohol dependent cases and 1254 controls of matched British and Irish ancestry.
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- Integrated lipid metabolomics and proteomics analysis reveal the pathogenesis of polycystic ovary syndrome.
Qian, Journal of translational medicine 2024 - “...4,250,366 6,880,411 1.62 0.69 0.000 0.003 P25311 AZGP1 563 751,209 1,195,863 1.59 0.67 0.000 0.003 P30837 ALDH1B1 219 2,173,243 1,349,944 1.61 -0.69 0.000 0.003 Q00266 MAT1A 4143 230,553 351,976 1.53 0.61 0.000 0.003 O14949 UQCRQ 27,089 803,205 488,817 1.64 0.72 0.000 0.003 P02774 GC 2638 3,965,445...”
- Sertoli cell-enriched proteins in mouse and human testicular interstitial fluid
O'Donnell, PloS one 2023 - “...P33897 ABCD1 ATP-binding cassette sub-family D member 1 No P55263-2 ADK * Adenosine kinase Yes P30837 ALDH1B1 Aldehyde dehydrogenase X, mitochondrial Yes Q14012 CAMK1 Calcium/calmodulin-dependent protein kinase type 1 No P10909-4 CLU * Clusterin Yes Q8N1G2 CMTR1 Cap-specific mRNA (nucleoside-2-O-)-methyltransferase 1 Yes P78310-3 CXADR Coxsackievirus and...”
- Proteomic and Metabolomic Analysis of Bone Marrow and Plasma from Patients with Extramedullary Multiple Myeloma Identifies Distinct Protein and Metabolite Signatures
Dunphy, Cancers 2023 - “...Thioredoxin-related transmembrane protein 2 TMX2 5.92 0.0014 Q13263 Transcription intermediary factor 1-beta TRIM28 2.19 0.0015 P30837 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 8.19 0.0015 Q9BY50 Signal peptidase complex catalytic subunit SEC11C SEC11C 5.19 0.0016 Q13813 Spectrin alpha chain, non-erythrocytic 1 SPTAN1 2.10 0.0023 Q3SY69 Mitochondrial 10-formyltetrahydrofolate dehydrogenase...”
- Characterization of human oxidoreductases involved in aldehyde odorant metabolism.
Boichot, Scientific reports 2023 - “...1, 0) 3-Oxo-5-beta-steroid 4-dehydrogenase (AKR1D1) P51857 1 (2, 1, 0) Aldehyde dehydrogenase X, mitochondrial (ALDH1B1) P30837 3 (0, 2, 0) Aldehyde dehydrogenase family 8 member A1 (ALDH8A1) Q9H2A2 1 (1, 1, 0) Retinal dehydrogenase 2 (ALDH1A2) O94788 3 (1, 0, 0) 3-Hydroxyacyl-CoA dehydrogenase type-2 Q99714 1...”
- Mitochondria-derived vesicles and their potential roles in kidney stone disease.
Chaiyarit, Journal of translational medicine 2023 - “...ligase, mitochondrial (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS) 31 AARS2 Q5JTZ9 AlaninetRNA ligase, mitochondrial 32 ALDH1B1 P30837 Aldehyde dehydrogenase X, mitochondrial (EC 1.2.1.3) (Aldehyde dehydrogenase 5) (Aldehyde dehydrogenase family 1 member B1) 33 ALDH7A1 P49419 Alpha-aminoadipic semialdehyde dehydrogenase (Alpha-AASA dehydrogenase) (EC 1.2.1.31) (Aldehyde dehydrogenase family 7 member...”
- Investigation of the potential mechanism of the Shugan Xiaozhi decoction for the treatment of nonalcoholic fatty liver disease based on network pharmacology, molecular docking and molecular dynamics simulation
Yang, PeerJ 2022 - “...P17931 LGALS3 Galectin-3 11 P31639 SLC5A2 Sodium/glucose cotransporter 2 11 P13726 F3 Tissue factor 10 P30837 ALDH1B1 Aldehyde dehydrogenase X, mitochondrial 7 O00748 CES2 Cocaine esterase 7 P05231 IL-6 Interleukin-6 7 P07237 P4HB Protein disulfide-isomerase 7 Outcome of the PPI network The PPI network was constructed...”
- Proteomic analysis of the umbilical cord in fetal growth restriction and preeclampsia.
Conrad, PloS one 2022 - “...-2.97 P08574 Cytochrome c1, heme protein, mitochondrial -2.87 Q9UNS2 COP9 signalosome complex subunit 3 -2.69 P30837 Aldehyde dehydrogenase X, mitochondrial -2.66 P00367 Glutamate dehydrogenase 1 -2.54 P07357 Complement component C8 alpha chain -2.41 O15061 Synemin; Type-VI intermediate filament -2.25 Q15717 ELAV-like protein 1 -2.19 P35573 Glycogen...”
- Anti-Cancer Auto-Antibodies: Roles, Applications and Open Issues.
de, Cancers 2021 - “...(late-stage patients) AHSG Alpha-2-HS-glycoprotein (Fetuin-A) P02765 Prostate cancer E N.A. N.A. ALDH1B1 Aldehyde dehydrogenase X P30837 Colorectal cancer I 62.3175.68% 73.7863.06% ALK Anaplastic lymphoma kinase Q9UM73 Lung cancer E N.A. N.A. NSCLC inversely correlated with stage of disease ALMS1 Alstrom syndrome protein 1 Q8TCU4 Lung cancer...”
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7mjcA / P30837 Crystal structure analysis of aldh1b1
38% identity, 95% coverage
- Ligand: nicotinamide-adenine-dinucleotide (7mjcA)
8rwkA / P46367 Cryoem structure of the central ald4 filament determined by filamentid (see paper)
39% identity, 91% coverage
- Ligand: nadp nicotinamide-adenine-dinucleotide phosphate (8rwkA)
FOXG_11443 aldehyde dehydrogenase (NAD+) from Fusarium oxysporum f. sp. lycopersici 4287
37% identity, 84% coverage
E4T72_11990 aldehyde dehydrogenase family protein from Staphylococcus xylosus
39% identity, 97% coverage
- Rhein against Staphylococcus xylosus by interfering with respiratory metabolism and inducing oxidative stress
Li, Current research in food science 2024 - “...name Fold change P-value A0A418I6B5 Aldehyde dehydrogenase BU104_10160 1.618 0.00023 A0A5F0V8A2 Aldehyde dehydrogenase family protein E4T72_11990 1.841 1.10E-06 A0A5F0V9V1 Long-chain fatty acid--CoA ligase fadD 2.164 0.00968 A0A5F0V8U0 Zinc-type alcohol dehydrogenase-like protein E4T72_11180 1.9 2.82E-06 C6ZDG5 NAD binding 3-hydroxy acyl-CoA dehydrogenase fadN 1.962 9.55E-05 A0A512SQK0 Glutaryl-CoA dehydrogenase...”
ALD6 / P54115 magnesium-activated aldehyde dehydrogenase, cytosolic (EC 1.2.1.4) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 3 papers)
ALDH6_YEAST / P54115 Magnesium-activated aldehyde dehydrogenase, cytosolic; Mg(2+)-activated acetaldehyde dehydrogenase; Mg(2+)-ACDH; EC 1.2.1.-; EC 1.2.1.4 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
P54115 aldehyde dehydrogenase (NAD+) (EC 1.2.1.3); aldehyde dehydrogenase (NADP+) (EC 1.2.1.4) from Saccharomyces cerevisiae (see 2 papers)
NP_015264 aldehyde dehydrogenase (NADP(+)) ALD6 from Saccharomyces cerevisiae S288C
YPL061W Ald6p from Saccharomyces cerevisiae
37% identity, 93% coverage
- function: Cytosolic aldehyde dehydrogenase which utilizes NADP(+) as the preferred coenzyme. Performs the conversion of acetaldehyde to acetate.
catalytic activity: acetaldehyde + H2O + NADP(+) = acetate + 2 H(+) + NADPH (RHEA:25298)
catalytic activity: H2O + NADP(+) + propanal = 2 H(+) + NADPH + propanoate (RHEA:27918)
catalytic activity: H2O + NAD(+) + propanal = 2 H(+) + NADH + propanoate (RHEA:67256) - ALDH1A3-acetaldehyde metabolism potentiates transcriptional heterogeneity in melanoma
Lu, Cell reports 2024 - “...--scaleFactor). AlphaFold Multimer modeling of ALD6-ACS2 and ALDH1A3-ACSS2 interaction Canonical sequences of yeast ALD6 (UniProt: P54115 ) and ACS2 (UniProt: P52910) and human ALDH1A3 (UniProt: P47895) and ACSS2 (UniProt: Q9NR19) were retrieved. 121 Disordered N-termini of the human proteins, the first 24 residues of each, were...”
- ALDH1A3-acetaldehyde metabolism potentiates transcriptional heterogeneity in melanoma
Lu, 2023 - Fatty aldehyde dehydrogenase multigene family involved in the assimilation of n-alkanes in Yarrowia lipolytica
Iwama, The Journal of biological chemistry 2014 - “...of sequences from UniProtKB are as follows: Ald1p/Ald6p (P54115), Ald2p (P47771), Ald3p (P54114), Ald4p (P46367), Ald5p (P40047), and Hfd1p (Q04458) of S....”
- Regulation of xylose metabolism in recombinant Saccharomyces cerevisiae
Salusjärvi, Microbial cell factories 2008 - “...1.0 P46367 Ald4p YOR374W aldehyde dehydrogenase (NAD + ) 1.7 -0.2 3.6 1.0 1.9 1.1 P54115 Ald6p_a YPL061W aldehyde dehydrogenase (NADP + ) -0.9 -2.6 0.2 -1.9 1.0 0.7 P54115 Ald6p_b YPL061W aldehyde dehydrogenase (NADP + ) -2.0 -2.6 -2.8 -1.9 -0.8 0.7 P28777 Aro2p YGL148W...”
- Mitochondrial NAD dependent aldehyde dehydrogenase either from yeast or human replaces yeast cytoplasmic NADP dependent aldehyde dehydrogenase for the aerobic growth of yeast on ethanol.
Mukhopadhyay, Biochimica et biophysica acta 2013 - GeneRIF: Mitochondrial NAD dependent aldehyde dehydrogenase either from yeast or human replaces yeast cytoplasmic NADP dependent aldehyde dehydrogenase for the aerobic growth of yeast on ethanol.
- Ald6p is a preferred target for autophagy in yeast, Saccharomyces cerevisiae.
Onodera, The Journal of biological chemistry 2004 (PubMed)- GeneRIF: Ald6p enzymatic activity may be disadvantageous for survival under nitrogen starvation; therefore, yeast cells may preferentially eliminate Ald6p via autophagy
- Molecular mechanics studies of factors affecting overall rate in cascade reactions: Multi-enzyme colocalization and environment
Kaushik, Protein science : a publication of the Protein Society 2024 - “...generate the modeled structures (Biasini et al., 2014 ). Sequence information from the Genome Database (YPL061W) and GenBank (NP_015022.3), along with template structures (PDB IDs: 6TGW and 3FP0) exhibiting sequence similarities of 26% and 43%, respectively, was utilized for modeling the enzymes Ald6 and Atf1, respectively...”
- A non-canonical Puf3p-binding sequence regulates CAT5/COQ7 mRNA under both fermentable and respiratory conditions in budding yeast
Hayashi, PloS one 2023 - “...independent of Puf3p Polysome YOR335C ALA1 Cytoplasmic and mitochondrial alanyl-tRNA synthetase undetermined Yes - Polysome YPL061W ALD6 Cytosolic aldehyde dehydrogenase undetermined No - Polysome YIL125W KGD1 Subunit of the mitochondrial alpha-ketoglutarate dehydrogenase complex Localized No independent of Puf3p Polysome YKL182W FAS1 Beta subunit of fatty acid...”
- Pareto optimal metabolic engineering for the growth-coupled overproduction of sustainable chemicals
Amaradio, Biotechnology and bioengineering 2022 - “...(KO) genes of Saccharomycescerevisiae . KO GeneKO GeneKO (standard name) and chromosomic locations 4 YDL171C, YPL061W, YPR160W, YPR127W GLT1 (IV), ALD6 (XVI), GPH1 (XVI), YPR127W 4 YBR221C, YDL171C, YPL061W, YPR160W PDB1 (II), GLT1 (IV), ALD6 (XVI), GPH1 (XVI) 4 YDL171C, YGR193C, YPL061W, YPR160W GLT1 (IV), PDX1...”
- “...YDL171C, YNL071W, YPL061W, YPR160W GLT1 (IV), LAT1 (XIV), ALD6 (XVI), GPH1 (XVI) 4 YDL171C, YER178W, YPL061W, YPR160W GLT1 (IV), PDA1 (V), ALD6 (XVI), GPH1 (XVI) 4 YDL171C, YHR002W, YPL061W, YPR160W GLT1 (IV), LEU5 (VIII), ALD6 (XVI), GPH1 (XVI) 9 YDL171C, YHR144C, YJR105W, YLR209C, YNL071W, YNL169C, YOR175C,...”
- Combinations of slow-translating codon clusters can increase mRNA half-life in Saccharomyces cerevisiae
Sharma, Proceedings of the National Academy of Sciences of the United States of America 2021 (secret) - Screening and Genetic Network Analysis of Genes Involved in Freezing and Thawing Resistance in DaMDHAR-Expressing Saccharomyces cerevisiae Using Gene Expression Profiling
Kim, Genes 2021 - “...iron/copper reductases YMR251W GTO3 5.008 Omega class glutathione transferase YOR374W ALD4 4.982 Mitochondrial aldehyde dehydrogenase YPL061W ALD6 4.828 Cytosolic aldehyde dehydrogenase YOR100C CRC1 4.597 Mitochondrial inner membrane carnitine transporter YOR348C PUT4 3.630 Proline permease YOR028C CIN5 3.522 Basic leucine zipper transcription factor of the yAP-1 family...”
- Commonalities and Differences in the Transcriptional Response of the Model Fungus Saccharomyces cerevisiae to Different Commercial Graphene Oxide Materials
Laguna-Teno, Frontiers in microbiology 2020 - “...be upregulated in the presence of GOC: YDL010W ( GRX6 ), YGR154C ( GTO1 ), YPL061W ( ALD6 ), YKL086W ( SRX1 ), YGR023W ( MTL1 ), and YLR380W ( CSR1 ) (see Supplementary Table 2 for exact values of fold change). Many studies have identified...”
- Yeast screen for modifiers of C9orf72 poly(glycine-arginine) dipeptide repeat toxicity
Chai, FEMS yeast research 2018 - “...YOL059W gph1 YPR160W stb5 YHR178W nnr2 ald6 YKL151C YPL061W yes Nucleotide biosynthetic pathway (7/133, P = 3.488e-5) ade1 YAR015W ade2 YOR128C ade4 YMR300C...”
- Overexpression of THI4 and HAP4 Improves Glucose Metabolism and Ethanol Production in Saccharomyces cerevisiae
Shi, Frontiers in microbiology 2018 - “...TCAATTTTTGCCCCGTATCTG R: GATAGCTCTGACGTGTGAATCAACA YHL032C GUT1 F: GCCCCAGCTCGTGAAACA R: GGGCTTTCCGCTGGTTTT YOL086C ADH1 F: GAAGGTGCCGGTGTCGTT R: ACCGATCTTCCAGCCCTTAAC YPL061W ALD6 F: GACAAAGTCAACGGTAGAACAATCA R: GGCTCTAAGGTGGTGAAGTTCATG YLR113W HOG1 F: GGGCATTTGGGTTGGTTTG R: TTAATGGCAACTGGCTGAGATG YML120C NDI1 F: GAGGCCGCTGGTGAACTACA R: GCCAATGCAGGGAGAAACTTT YPR002W PDH1 F: CTTACCGTCATGCCCCAAAT R: AGCCCTCGAAACTGCATCTC YER148W SPT15 F: ACATGCCCGTAATGCAGAATATAA R: GGCTCTCTAATACGCATGATGACA YKL062W...”
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FGSG_02160 aldehyde dehydrogenase from Fusarium graminearum PH-1
37% identity, 97% coverage
- Functional Characterization of Aldehyde Dehydrogenase in Fusarium graminearum
Tang, Microorganisms 2023 - “...coding for aldehyde dehydrogenase ( FGSG_04194 , FGSG_00139 , FGSG_11482 , FGSG_05375 , FGSG_00979 , FGSG_02160 , FGSG_05831 , FGSG_02273 , and FGSG_01759 ) were identified in F. graminearum . It is unclear why efforts to knockout FGSG_ 02273 and FGSG_01759 did not succeed. An evaluation...”
- “...suggests that ALDHs play a significant role in detoxification. The conserved domain, ALD2, of the FGSG_02160 is highly analogous to the ALDH2 of brewers yeast (YMR170c) and is mainly responsible for ethanol oxidation and -alanine biosynthesis. The FGSG_00979 protein contains a conserved domain in ALDH_F1-2_Ald2-like, which...”
ALD4 / P46367 potassium-activated aldehyde dehydrogenase, mitochondrial (EC 1.2.1.4; EC 1.2.1.3) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 2 papers)
ALDH4_YEAST / P46367 Potassium-activated aldehyde dehydrogenase, mitochondrial; K(+)-activated acetaldehyde dehydrogenase; K(+)-ACDH; EC 1.2.1.-; EC 1.2.1.4 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 4 papers)
P46367 aldehyde dehydrogenase [NAD(P)+] (EC 1.2.1.5) from Saccharomyces cerevisiae (see paper)
NP_015019 aldehyde dehydrogenase (NADP(+)) ALD4 from Saccharomyces cerevisiae S288C
YOR374W Ald4p from Saccharomyces cerevisiae
39% identity, 87% coverage
- function: Potassium-activated aldehyde dehydrogenase involved in acetate formation during anaerobic growth on glucose.
catalytic activity: acetaldehyde + H2O + NADP(+) = acetate + 2 H(+) + NADPH (RHEA:25298)
catalytic activity: H2O + NADP(+) + propanal = 2 H(+) + NADPH + propanoate (RHEA:27918)
catalytic activity: H2O + NAD(+) + propanal = 2 H(+) + NADH + propanoate (RHEA:67256) - An Isoform of the Eukaryotic Translation Elongation Factor 1A (eEF1a) Acts as a Pro-Viral Factor Required for Tomato Spotted Wilt Virus Disease in Nicotiana benthamiana
Helderman, Viruses 2021 - “...biogenesis NbS00009856g0011.1 P36520 MRPL10 54S ribosomal protein L10 KOG0846 Translation, ribosomal structure, and biogenesis NbS00003478g0004.1 P46367 ALD4 Potassium-activated aldehyde dehydrogenase KOG2450 Energy production and conversion NbS00048826g0001.1 P32610 VMA8 V-type proton ATPase subunit D KOG1647 Energy production and conversion NbS00039262g0004.1 P40557 EPS1 ER-retained PMA1-suppressing protein 1 KOG0191...”
- Coupled regulations of enzymatic activity and structure formation of aldehyde dehydrogenase Ald4p
Noree, Biology open 2020 - “...dehydrogenase Ald4p and amino acid residues selected for site-directed mutagenesis. The 3D model of Ald4p (P46367) is provided by MODBASE, based on template 1bi9A (with 50% sequence identity; alignment shown in Fig.S2 ; www.proteinmodelportal.org ). Four amino acid residues of Ald4p were selected for site-directed mutagenesis...”
- Proteomic analysis reveals a novel function of the kinase Sat4p in Saccharomyces cerevisiae mitochondria
Gey, PloS one 2014 - “...of pyruvate dehydrogenase complex, mitochondrial 2.54 nanoLC-MS/MS 2549 20 52 51.8 7.80 60 5.7 ALD4 P46367 Potassium-activated aldehyde dehydrogenase, mitochondrial nanoLC-MS/MS 5337 30 76 56.7 6.74 FCJ1 P36112 Formation of crista junctions protein 1 nanoLC-MS/MS 2219 26 58 61.1 6.60 11 KGD2 P19262 Dihydrolipoyllysine-residue succinyltransferase component...”
- Fatty aldehyde dehydrogenase multigene family involved in the assimilation of n-alkanes in Yarrowia lipolytica
Iwama, The Journal of biological chemistry 2014 - “...Ald1p/Ald6p (P54115), Ald2p (P47771), Ald3p (P54114), Ald4p (P46367), Ald5p (P40047), and Hfd1p (Q04458) of S. cerevisiae, and YALI0E00264p (Q6C7J6),...”
- Mitochondrial enzymes are protected from stress-induced aggregation by mitochondrial chaperones and the Pim1/LON protease
Bender, Molecular biology of the cell 2011 - “...in supernatant (%) 1 Aco1 Aconitate hydratase P21147 85 84 25 2 Ald4 Aldehyde dehydrogenase P46367 57 110 42 3 Atp1 F 1 F O ATPase complex, subunit P07251 59 88 32 4 Atp2 F 1 F O ATPase complex, subunit P00830 55 106 35 5...”
- Regulation of xylose metabolism in recombinant Saccharomyces cerevisiae
Salusjärvi, Microbial cell factories 2008 - “...0.5 -0.2 1.0 -0.2 P54114 Ald3p YMR169C aldehyde dehydrogenase 0.4 0.8 1.8 1.8 1.4 1.0 P46367 Ald4p YOR374W aldehyde dehydrogenase (NAD + ) 1.7 -0.2 3.6 1.0 1.9 1.1 P54115 Ald6p_a YPL061W aldehyde dehydrogenase (NADP + ) -0.9 -2.6 0.2 -1.9 1.0 0.7 P54115 Ald6p_b YPL061W...”
- FilamentID reveals the composition and function of metabolic enzyme polymers during gametogenesis.
Hugener, Cell 2024 (PubMed)- GeneRIF: FilamentID reveals the composition and function of metabolic enzyme polymers during gametogenesis.
- Robust assembly of the aldehyde dehydrogenase Ald4p in Saccharomyces cerevisiae.
Nasalingkhan, Biology open 2023 - GeneRIF: Robust assembly of the aldehyde dehydrogenase Ald4p in Saccharomyces cerevisiae.
- Two sources of mitochondrial NADPH in the yeast Saccharomyces cerevisiae.
Miyagi, The Journal of biological chemistry 2009 - GeneRIF: there are two sources of mitochondrial NADPH in yeast: one is the mitochondrial Pos5p-NADH kinase reaction and the other is the mitochondrial Pos5p-NAD kinase reaction followed by the mitochondrial Ald4/5 reaction.
- The regulatory mechanism of the yeast osmoresponse under different glucose concentrations
Shen, iScience 2023 - “...Tps2-GFP 2E 7 YOR173W Dcs2-GFP 5F 23 YMR105C Pgm2-GFP 3D 12 YHR008C Sod2-GFP 8G 11 YOR374W Ald4-GFP 4I 4 YDR368W Ypr1-GFP 6B 20 YPR160W Gph1-GFP 2M 3 YHR043C Dog2-GFP 7D 18 YOR185C Gsp2-GFP 11B 5 YFR053C Hxk1-GFP 4J 17 YLR113W Hog1-GFP 5A 4 msn2msn4 strain Hog1-GFP...”
- Screening and Genetic Network Analysis of Genes Involved in Freezing and Thawing Resistance in DaMDHAR-Expressing Saccharomyces cerevisiae Using Gene Expression Profiling
Kim, Genes 2021 - “...5.285 Protein with sequence similarity to iron/copper reductases YMR251W GTO3 5.008 Omega class glutathione transferase YOR374W ALD4 4.982 Mitochondrial aldehyde dehydrogenase YPL061W ALD6 4.828 Cytosolic aldehyde dehydrogenase YOR100C CRC1 4.597 Mitochondrial inner membrane carnitine transporter YOR348C PUT4 3.630 Proline permease YOR028C CIN5 3.522 Basic leucine zipper...”
- Metschnikowia pulcherrima Influences the Expression of Genes Involved in PDH Bypass and Glyceropyruvic Fermentation in Saccharomyces cerevisiae
Sadoudi, Frontiers in microbiology 2017 - “...20 ALD6 (YPL061W) 856044 Cytosolic aldehyde dehydrogenase, isozyme 6 TCTCTTCTGCCACCACTGAA 20 100 CCTCTTTCTCTTGGGTCTTGG 21 ALD4 (YOR374W) 854556 Mitochondrial aldehyde dehydrogenase, isozyme 4 CGGGTTTGGTAAGATTGTGG 20 106 TGCGGACTGGTAAATGTGTC 20 ACS2 (YLR153C) 850846 Acetyl-CoA synthase, isozyme 2 ATTGGTCCTTTCGCCTCAC 19 118 GCTGTTCGGCTTCGTTAGA 19 ADH1 (YOL086C) 854068 Alcohol dehydrogenase, isozyme 1...”
- Different specificities of two aldehyde dehydrogenases from Saccharomyces cerevisiae var. boulardii
Datta, Bioscience reports 2017 - “...into cytosolic and mitochondrial enzymes. ALD2 ( YMR170C ), ALD3 ( YMR169C ), ALD4 ( YOR374W ), ALD5 ( YER073W ) and ALD6 ( YPL061W ) are the five different gene products identified in these categories [ 19 , 20 ]. Two cytosolic (Ald2p and Ald3p)...”
- ALD5, PAD1, ATF1 and ATF2 facilitate the catabolism of coniferyl aldehyde, ferulic acid and p-coumaric acid in Saccharomyces cerevisiae
Adeboye, Scientific reports 2017 - “...and sequentially named ALD2-ALD6. ALD6 (YPL061w), ALD2 (YMR170c) and ALD3 (YMR169c) are cytosolic, while ALD4 (YOR374w) and ALD5 (YER073w) are mitochondrial 19 . The ALD genes have also been reported to exhibit redundancy, although they use different co-factors 19 20 . The redundancy in the ALD...”
- Aldehyde dehydrogenase, Ald4p, is a major component of mitochondrial fluorescent inclusion bodies in the yeast Saccharomyces cerevisiae
Misonou, Biology open 2014 - “...at positions 24 to 33 of mitochondrial aldehyde dehydrogenase Ald4p, which is encoded by ALD4 (YOR374W). To compare the enzyme activity among the mitochondrial fractions, the activities of aldehyde dehydrogenase were measured in 7 fractions, as was that of fumarase as a marker enzyme of mitochondria...”
- Defects in mitochondrial fatty acid synthesis result in failure of multiple aspects of mitochondrial biogenesis in Saccharomyces cerevisiae
Kursu, Molecular microbiology 2013 - “...MATaade2, ade3, can1-100, his3-11,15; leu2-3,112; trp1-1, ura3-1 ( Kastaniotis et al. , 2004 ) ald4 yor374w, kanMX4 This study cbp2 yhl038c, kanMX4 This study cem1 yer061c, kanMX4 This study etr1 ybr026c, kanMX4 This study etr1 0 ybr026c, kanMX4, 0 This study ietr1 ybr026c, kanMX4, intronless mtDNA...”
- “...mss51 F199I This study FabI ybr026c, kanMX4, mtFabI This study FabI ald4 ybr026c, kanMX4, mtFabI, yor374w, kanMX4 This study FabI mrps5 ybr026c, kanMX4, mtFabI, ybr251w, kanMX4 This study gcv3 yal044c, kanMX4 This study htd2 yhr067w, kanMX4 This study htd2 0 yhr067w, kanMX4, 0 This study ihtd2...”
- Adjustment of trehalose metabolism in wine Saccharomyces cerevisiae strains to modify ethanol yields
Rossouw, Applied and environmental microbiology 2013 - “...YMR303c YMR083w YGL256w YBR145w YPL061w YMR169c YMR170c YOR374w Y16236 Y10891 Y16217 Y14623 Y13284 Y12767 Y10752 Y10753 Y11671 Trehalose metabolism...”
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Rmet_4942 succinate-semialdehyde dehydrogenase I, NADP-dependent from Ralstonia metallidurans CH34
Rmet_4942 NAD-dependent succinate-semialdehyde dehydrogenase from Cupriavidus metallidurans CH34
38% identity, 97% coverage
NP_695212 retinaldehyde dehydrogenase 3 from Rattus norvegicus
39% identity, 92% coverage
F7H5N9 Aldehyde dehydrogenase X, mitochondrial from Macaca mulatta
38% identity, 91% coverage
- Comparative genomics, molecular evolution and computational modeling of ALDH1B1 and ALDH2
Jackson, Chemico-biological interactions 2013 - “...(ve) inc inc na 117 71 98 63 Rhesus Macaca mulatta 1B1 XP_001114412 a EHH23951 F7H5N9 517 15:39,015,75439,017,304 1 (ve) 1551 57,175 na 117 71 98 64 Marmoset Callithrix jacchus 1B1 XP_002743154 a Na na 514 1:140,345,262140,346,964 2 (+ve) 1703 56,987 na 112 71 96 64...”
Q8K4D8 retinal dehydrogenase (EC 1.2.1.36) from Rattus norvegicus (see paper)
39% identity, 92% coverage
A9EEP5 Aldehyde dehydrogenase family 1 subfamily A3 from Rattus norvegicus
39% identity, 92% coverage
hpaE / Q46979 subunit of 5-carboxymethyl-2-hydroxymuconic semialdehyde dehydrogenase (EC 1.2.1.60) from Escherichia coli (see 2 papers)
37% identity, 97% coverage
SSDH_ARATH / Q9SAK4 Succinate-semialdehyde dehydrogenase, mitochondrial; At-SSADH1; Aldehyde dehydrogenase family 5 member F1; NAD(+)-dependent succinic semialdehyde dehydrogenase; Protein ENLARGED FIL EXPRESSING DOMAIN 1; EC 1.2.1.24 from Arabidopsis thaliana (Mouse-ear cress) (see 8 papers)
AT1G79440 ALDH5F1; 3-chloroallyl aldehyde dehydrogenase/ NAD or NADH binding / succinate-semialdehyde dehydrogenase from Arabidopsis thaliana
NP_178062 aldehyde dehydrogenase 5F1 from Arabidopsis thaliana
37% identity, 90% coverage
- function: Oxidizes specifically succinate semialdehyde. Involved in plant response to environmental stress by preventing the accumulation of reactive oxygen species, probably by regulating proline, gamma- hydroxybutyrate (GHB) and gamma-aminobutyrate (GABA) levels (PubMed:15642352). Required for the maintenance of the shoot apical meristem (SAM) structure and subsequent adaxial-abaxial axis-dependent development of cotyledons and leaves (PubMed:21690177, PubMed:25840087).
catalytic activity: H2O + NAD(+) + succinate semialdehyde = 2 H(+) + NADH + succinate (RHEA:13217)
subunit: Homotetramer.
disruption phenotype: Plants are sensitive to UVB and heat stress, and accumulate elevated levels of H(2)O(2) (PubMed:12740438). High light- dependent increased of proline, gamma-hydroxybutyrate (GHB) and gamma- aminobutyrate (GABA) levels. Treatment with gamma-vinyl-gamma- aminobutyrate, a specific gamma-aminobutyrate (GABA)-transaminase inhibitor, prevents the accumulation of reactive oxygen intermediates (ROI) and GHB in ssadh mutants, inhibits cell death, and improves growth (PubMed:15642352). The ssadh mutant defects associated with stress responses are suppressed by POP2 disruption (PubMed:18846220). In enf1, pleiotropic developmental defects including dwarfism, and abnormal leaf shape (including abaxialized and adaxialized leaves) and cotyledon associated with altered GABA and SucA levels in shoots; these phenotypes are partially suppressed by the disruption of POP2/GABAT1, GSA1, GSA2 and HEMA1 (PubMed:21690177, PubMed:25840087). Abnormal FIL expression, especially in the adaxial side, in the leaf primordia (PubMed:21690177). - The m6A reader ECT8 is an abiotic stress sensor that accelerates mRNA decay in Arabidopsis
Cai, The Plant cell 2024 - “...genomics viewer (IGV) showing the m 6 A-seq and FA-CLIP sequencing results on AT5G13570 and AT1G79440 transcripts. FA-CLIP, formaldehyde crosslinking and immunoprecipitation. G) The RNA half-lives of AT5G13570 and AT1G79440 transcripts in 7-d-old WT and ect8-1 seedlings. External spike-ins were used as internal control. WT, wild-type....”
- “...function of ECT8 and DCP5 in mRNA degradation. Moreover, we selected 4 DCP5-targeted genes, AT5G13570, AT1G79440, AT3G45970, and AT1G03440, for further confirmation. Among them, AT5G13570 and AT3G45970 have been validated ( Xu and Chua 2009 ). The results from FA-CLIP and m 6 A-seq showed that...”
- Metabolic enzymes moonlight as selective autophagy receptors to protect plants against viral-induced cellular damage
Clavel, 2024 - Identification and function analysis of GABA branch three gene families in the cotton related to abiotic stresses
Zheng, BMC plant biology 2024 - “...genes (AT2G02010, AT5G17330, AT2G02000, AT1G65960, AT3G17760, AT3G17720), 1 GABA-T gene (AT3G22200), and 1 SSADH gene (AT1G79440). Bioedit software ( http://www.mbio.ncsu.edu/bioedit/page2.html (accessed on)) was employed for trimming and alignment of the protein sequences of the different cotton varieties, including upland, Asian, and G. raimondii varieties separately. The...”
- NTRC and thioredoxins m1/m2 underpin the light acclimation of plants on proteome and metabolome levels
Dziubek, Plant physiology 2024 - “...cytosol AT4G39330 Probable cinnamyl alcohol dehydrogenase 9 cytosol AT1G17990 Putative 12-oxophytodienoate reductase-like protein 2A cytosol AT1G79440 Succinate-semialdehyde dehydrogenase mitochondrion AT2G45770 Cell division protein FtsY homolog plastid AT5G21430 NAD(P)H-quinone oxidoreductase subunit U plastid AT4G22890 PGR5-like protein 1A plastid AT1G06690 Uncharacterized oxidoreductase plastid Significances on protein level were...”
- Deciphering the molecular basis of abiotic stress response in cucumber (Cucumis sativus L.) using RNA-Seq meta-analysis, systems biology, and machine learning approaches
Zinati, Scientific reports 2023 - “...protein) response to endoplasmic reticulum stress, and response to inorganic substance; AT5G12380 ( ANNAT8 ), AT1G79440 ( ALDH5F1 ), AT3G53110 ( LOS4 ) in response to cold, and response to heat. One unexpected GO-term was a response to cadmium ion that drew our attention. An explanation...”
- Phenotypic effects from the expression of a deregulated AtGAD1 transgene and GABA pathway suppression mutants in maize
S, PloS one 2021 - “...et al. [ 37 ] reported that the loss of function Arabidopsis SSADH knock-out plants (At1g79440) had greater sensitivity to oxidative damage due to hyper-accumulation of ROIs (Reactive Oxygen Intermediates) under light and heat stress. Bouche et al. 2003 [ 38 ] demonstrated that the GABA...”
- Network Topological Analysis for the Identification of Novel Hubs in Plant Nutrition
Di, Frontiers in plant science 2021 - “...Csa_6G497310 SHM1 (AT4G37930) 80% 869 9 2 10 28 Serine hydroxymethyl transferase A0A0A0KGA1 Csa_6G135470 ALDH5F1 (AT1G79440) 77% 813 3,5 3,0E-02 7 3 9 20 Succinate-semialdehyde dehydrogenase A0A0A0L5J6 Csa_3G115030 AT5G40810 87% 514 3,4 3,6E-02 6 8 5 18 Cytochrome c1 component of cyt-bc1 complex A0A0A0LP60 Csa_2G360050 SDH5...”
- Profiling of advanced glycation end products uncovers abiotic stress-specific target proteins in Arabidopsis
Chaplin, Journal of experimental botany 2019 - “...h ADK1 Q9SF85-2 AT3G09820 4.11 2.16 1.95 RPL23AB Q9M3C3 AT3G55280 2.63 2.21 0.418 ALDH5F1 Q9SAK4 AT1G79440 0.492 1.46 0.973 MPPA2 O04308 AT3G16480 1.3 1.63 2.93 Q0WW26 Q0WW26 AT4G34450 2.41 0.551 1.86 GLN1-3 Q9LVI8 AT3G17820 3.03 0.948 2.08 XYL1 Q9S7Y7 AT1G68560 1.98 1.18 3.16 AGP31 Q9FZA2-2 AT1G28290...”
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- Kinetic and structural insights into enzymatic mechanism of succinic semialdehyde dehydrogenase from Cyanothece sp. ATCC51142
Xie, PloS one 2020 - “...GabD from E . coli (NP_417147), GabD from Human (NP_001071), GabD from A . thaliana (NP_178062), YneI from Bacillus subtilis (ARW30050). Triangle indicates residues involved in cofactor preference, and pentagram indicates residues involved in enzyme catalysis. 10.1371/journal.pone.0239372.g006 Fig 6 Structural modeling of cce4228 protein. A. The...”
- Structural basis for a cofactor-dependent oxidation protection and catalysis of cyanobacterial succinic semialdehyde dehydrogenase
Park, The Journal of biological chemistry 2013 - “...AtSSADH for A. thaliana SSADH (gene accession no. NP_178062), and HsSSADH for human SSADH (gene accession no. NP_001071). Note that the catalytic loop is...”
- Succinic semialdehyde dehydrogenase is involved in the robust patterning of Arabidopsis leaves along the adaxial-abaxial axis.
Toyokura, Plant & cell physiology 2011 (PubMed)- GeneRIF: The ENF1 gene encodes SUCCINIC SEMIALDEHYDE DEHYDROGENASE (SSADH), which catalyzes the conversion of succinic semialdehyde (SSA) to succinate.
- Mutants of GABA transaminase (POP2) suppress the severe phenotype of succinic semialdehyde dehydrogenase (ssadh) mutants in Arabidopsis.
Ludewig, PloS one 2008 - GeneRIF: Data suggest that POP2 mutants suppress the phenotype of succinic semialdehyde dehydrogenase (ssadh) mutants in Arabidopsis.
- Physiological and Transcriptional Responses of Apocynum venetum to Salt Stress at the Seed Germination Stage
Li, International journal of molecular sciences 2023 - “...AVP1 P31414 Pyrophosphate-energized vacuolar membrane proton pump 1 3.98 REM4.1 Q93YN8 Remorin 4.1 1.16 ALDH5F1 Q9SAK4 Succinate-semialdehyde dehydrogenase 4.24 TIL Q9FGT8 Temperature-induced lipocalin-1 4.08 WSD1 Q93ZR6 Wax ester synthase/diacylglycerol acyltransferase 1 1.11 At2g40140 Q9XEE6 Zinc finger CCCH domain-containing protein 29 1.30 Os07g0682400 Q0D3J9 Zinc finger CCCH...”
- Parthenium hysterophorus steps up Ca-regulatory pathway in defence against highlight intensities
Ahmad, Scientific reports 2020 - “...thaliana gi190358919 13.8/5.9 13.4/5.8 PSBP1 61 Photosynthesis Calcium ion binding S29 Succinate-semialdehyde dehydrogenase Arabidopsis thaliana/ Q9SAK4 56.0/6.3 56.9/6.5 ALDH5F1 SSADH1 T8K14.14 23 Involved in plant response to environmental stress S30 Peptide methionine sulfoxide reductase B4 Arabidopsis thaliana/ Q9M0Z5 20.7/4.2 15.5/5.3 MSRB4 46 Plays a protective role...”
- Profiling of advanced glycation end products uncovers abiotic stress-specific target proteins in Arabidopsis
Chaplin, Journal of experimental botany 2019 - “...16.00 h ADK1 Q9SF85-2 AT3G09820 4.11 2.16 1.95 RPL23AB Q9M3C3 AT3G55280 2.63 2.21 0.418 ALDH5F1 Q9SAK4 AT1G79440 0.492 1.46 0.973 MPPA2 O04308 AT3G16480 1.3 1.63 2.93 Q0WW26 Q0WW26 AT4G34450 2.41 0.551 1.86 GLN1-3 Q9LVI8 AT3G17820 3.03 0.948 2.08 XYL1 Q9S7Y7 AT1G68560 1.98 1.18 3.16 AGP31 Q9FZA2-2...”
- Transcriptomic and metabolite analyses of Cabernet Sauvignon grape berry development
Deluc, BMC genomics 2007 - “...3 3.59 1617448_at BQ795936 TC54982 Q9M6B3 Malate dehydrogenase Organic Acid 10 3.48 1606935_at CB969531 TC66898 Q9SAK4 Succinic semialdehyde dehydrogenase 1 Organic acid 3 3.05 1620641_at CF511421 TC52472 Q39540 AOBP-like protein Organic Acid 9 2.11 1611871_at CF415063 TC54132 Q84UH4 Dehydroascorbate reductase Organic Acid 19 2.1 1609147_at CB979150...”
BU104_12250 aldehyde dehydrogenase family protein from Staphylococcus xylosus
39% identity, 97% coverage
C1LFP4 Putative aldehyde dehydrogenase 1B1 from Schistosoma japonicum
38% identity, 95% coverage
- Effect of Praziquantel on Schistosoma mekongi Proteome and Phosphoproteome
Chienwichai, Pathogens (Basel, Switzerland) 2020 - “...182.4 5.6 873 28.2 2.0 Energy 4 B2LXU1 Enolase 46.7 6.77 130 24.7 3.12 5 C1LFP4 Putative aldehyde dehydrogenase 1B1 precursor 53.5 6.06 379 28.9 4.0 6 G4LWI3 Aldehyde dehydrogenase, putative 53.7 5.76 113 19.8 2.86 7 B2LXU3 Glyceraldehyde 3-phosphate dehydrogenase 36.5 7.68 152 33.4 2.63...”
- “...Glyceraldehyde 3-phosphate dehydrogenase Down 34 B2LXU3 Glyceraldehyde 3-phosphate dehydrogenase Down 35 B2LXU1 Enolase Down 36 C1LFP4 Putative aldehyde dehydrogenase 1B1 precursor Down 37 G4LWI3 Aldehyde dehydrogenase, putative Down 38 A0A095A4B6 Aldehyde dehydrogenase X, mitochondrial Down 39 Q5DAK2 SJCHGC06828 protein Down 40 Q5BXP5 SJCHGC05927 protein, partial Down...”
Bxe_B2030 5-carboxy-2-hydroxymuconate semialdehyde dehydrogenase (HpaE) from Burkholderia xenovorans LB400
Bxe_B2030 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase from Paraburkholderia xenovorans LB400
37% identity, 96% coverage
Q66HF8 Aldehyde dehydrogenase X, mitochondrial from Rattus norvegicus
38% identity, 91% coverage
- Functional proteomic analysis of corticosteroid pharmacodynamics in rat liver: Relationship to hepatic stress, signaling, energy regulation, and drug metabolism.
Ayyar, Journal of proteomics 2017 - “...UP/DOWN Q8BH00 Aldh8a1 Aldehyde dehydrogenase family 8 member A1 Converts 9-cis-retinal to 9-cis-retinoic acid UP Q66HF8 Aldh1b1 Aldehyde dehydrogenase 1B1, mitochondrial Ethanol degradation - transformation from acetaldehyde to acetic acid UP Q8K009 Aldh1l2 Aldehyde dehydrogenase 1L2, mitochondrial Formate oxidation (homolog of 10-formyltetrahydrofolate dehydrogenase) UP Q9JLJ3 Aldh9a1...”
- Comparative genomics, molecular evolution and computational modeling of ALDH1B1 and ALDH2
Jackson, Chemico-biological interactions 2013 - “...1 (+ve) 1557 57,553 2.8 119 72 94 65 Rat Rattus norvegicus 1b1 NM_001011975 BC081884 Q66HF8 519 5:62,314,15662,315,712 1 (+ve) 1557 57,625 0.1 119 71 93 65 Pig Sus scrofa 1B1 XP_003353634 a AK347304 na 517 1: 250,617,521250,619,071 1 (+ve) 1551 57,535 na 117 71 94...”
- Mechanism of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy)-mediated mitochondrial dysfunction in rat liver.
Moon, Proteomics 2008 - “...5 Aldehyde dehydrogenase family 7 member A1 (ALDH7) Q64057 3 Aldehyde dehydrogenase X (ALDH X) Q66HF8 3 Voltage-dependent T-type calcium channel subunit -1G (VSCC) O54898 2 ATP synthase subunit alpha (-ATP) P15999 2 5 Methylmalonate-semialdehyde dehydrogenase (ALDH6) Q02253 21 Glutamate dehydrogenase 1 (GDH) P10860 12 UDP-glucose...”
- “...3 Aldehyde dehydrogenase family 7 member A1 (ALDH7) Q64057 2 Aldehyde dehydrogenase X (ALDH X) Q66HF8 2 Cytochrome P450 11B1 P15393 2 6 Methylmalonate-semialdehyde dehydrogenase (ALDH6) Q02253 16 Glutamate dehydrogenase 1 (GDH) P10860 15 Cytochrome P450 11B1 P15393 2 UDP-glucose pyrophosphorylase 2 Q4V8I9 2 7 Methylmalonate-semialdehyde...”
AL1A3_MOUSE / Q9JHW9 Retinaldehyde dehydrogenase 3; RALDH-3; RalDH3; Aldehyde dehydrogenase 6; Aldehyde dehydrogenase family 1 member A3; Aldh1a3; EC 1.2.1.36 from Mus musculus (Mouse) (see 7 papers)
Q9JHW9 retinal dehydrogenase (EC 1.2.1.36); aldehyde dehydrogenase [NAD(P)+] (EC 1.2.1.5) from Mus musculus (see 4 papers)
NP_444310 retinaldehyde dehydrogenase 3 from Mus musculus
39% identity, 92% coverage
- function: Catalyzes the NAD-dependent oxidation of aldehyde substrates, such as all-trans-retinal and all-trans-13,14-dihydroretinal, to their corresponding carboxylic acids, all-trans-retinoate and all-trans- 13,14-dihydroretinoate, respectively (PubMed:11013254, PubMed:11044606, PubMed:14623956, PubMed:15911617). High specificity for all-trans- retinal as substrate, can also accept acetaldehyde as substrate in vitro but with lower affinity (By similarity). Required for the biosynthesis of normal levels of retinoate in the embryonic ocular and nasal regions; a critical lipid in the embryonic development of the eye and the nasal region (PubMed:14623956).
catalytic activity: H2O + NAD(+) + retinal = 2 H(+) + NADH + retinoate (RHEA:16177)
catalytic activity: all-trans-retinal + H2O + NAD(+) = all-trans-retinoate + 2 H(+) + NADH (RHEA:42080)
catalytic activity: all-trans-13,14-dihydroretinal + H2O + NAD(+) = all-trans- 13,14-dihydroretinoate + 2 H(+) + NADH (RHEA:75119)
subunit: Homotetramer.
disruption phenotype: Mutant mice are born at the expected Mendelian rate, but all die within 10 hours after birth (PubMed:14623956, PubMed:23536097). Lethality is due to respiratory distress, caused by choanal atresia, i.e. the lack of communication between the nasal and oral cavities. Mutant embryos at 11.5 dpc lack detectable retinoic acid in the ventral retina, nasal epithelium and in the nasolacrimal groove. At 14.5 dpc mutant embryos display shortening of the ventral retina associated with lens rotation and persistence of the retrolenticular membrane, indicative of retinoic acid deficiency. Still, at 18.5 dpc the ventral retina appears normal. Embryos at 18.5 dpc lack Harderian glands, and display multiple malformations in the nasal region, including choanal atresia, lack of maxillary sinuses and nasolacrimal ducts (PubMed:14623956). Oral gavage of pregnant females with retinoic acid prevents choanal atresia and other malformations of the nasal region (PubMed:14623956, PubMed:23536097). Females that were fed retinoic acid give birth to pups with malformations of the inner ear vestibular organ, causing repetitive circling behavior with head tilting (PubMed:23536097). Likewise, mice display impaired ability in crossing a beam without slipping and an impaired ability to swim (PubMed:23536097). - ALDH1A1 and ALDH1A3 paralogues of aldehyde dehydrogenase 1 control myogenic differentiation of skeletal muscle satellite cells by retinoic acid-dependent and -independent mechanisms.
Steingruber, Cell and tissue research 2023 (PubMed)- GeneRIF: ALDH1A1 and ALDH1A3 paralogues of aldehyde dehydrogenase 1 control myogenic differentiation of skeletal muscle satellite cells by retinoic acid-dependent and -independent mechanisms.
- microRNA-483 Protects Pancreatic β-Cells by Targeting ALDH1A3.
Wang, Endocrinology 2021 - GeneRIF: microRNA-483 Protects Pancreatic beta-Cells by Targeting ALDH1A3.
- ALDH1A3 Coordinates Metabolism With Gene Regulation in Pulmonary Arterial Hypertension.
Li, Circulation 2021 - GeneRIF: ALDH1A3 Coordinates Metabolism With Gene Regulation in Pulmonary Arterial Hypertension.
- CHD7 represses the retinoic acid synthesis enzyme ALDH1A3 during inner ear development.
Yao, JCI insight 2018 - GeneRIF: Study using human SH-SY5Y neuroblastoma and 293T cells and transgenic mouse model show that CHD7 directly regulates expression of retinoic acid synthetic enzyme ALDH1A3. Results indicate that ALDH1A3 acts with CHD7 in a common genetic pathway to regulate inner ear development, providing insights for exploration of the pathogenic mechanisms underlying CHARGE syndrome.
- Aldehyde dehydrogenase 1a3 defines a subset of failing pancreatic β cells in diabetic mice.
Kim-Muller, Nature communications 2016 - GeneRIF: Study in diabetic mice reports the discovery of ALDH1A3 isoform as a biomarker of dysfunctional beta cells.
- Sam68 promotes self-renewal and glycolytic metabolism in mouse neural progenitor cells by modulating Aldh1a3 pre-mRNA 3'-end processing.
La, eLife 2016 - GeneRIF: This study identifies Sam68 as a key regulator of neural progenitor cell self-renewal and establishes a novel link between modulation of ALDH1A3 expression and maintenance of high glycolytic metabolism in the developing cortex.
- Expression of aldehyde dehydrogenase family 1, member A3 in glycogen trophoblast cells of the murine placenta.
Outhwaite, Placenta 2015 (PubMed)- GeneRIF: Data suggest that expression of Aldh1a3/Raldh3 in placenta plays role in differentiation/placentation of glycogen trophoblast cells (junctional zone cells) via production of a local source of retinoic acid.
- Whole-Exome Sequencing in a South American Cohort Links ALDH1A3, FOXN1 and Retinoic Acid Regulation Pathways to Autism Spectrum Disorders.
Moreno-Ramos, PloS one 2015 - GeneRIF: Chromatin immunoprecipitation assay using RarB as the immunoprecipitation target suggests retinoic acid regulation of Aldh1a3 and Foxn1 in mice.
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- Effects of Doxorubicin on Extracellular Matrix Regulation in Primary Cardiac Fibroblasts from Mice.
Skaggs, BMC research notes 2023 - “...Q64695 Endothelial protein C receptor 3.3 P13597-2 Isoform 2 of Intercellular adhesion molecule 1 2.5 Q9JHW9 Aldehyde dehydrogenase family 1 member A3 2.4 P48999 Arachidonate 5-lipoxygenase 2.0 P16125 L-lactate dehydrogenase B chain 2.0 Q9CRC6 BLOC-1-related complex subunit 7 1.9 Q62433 Protein NDRG1 1.8 Q5I2A0 Serine protease...”
- Pressure Cycling Technology Assisted Mass Spectrometric Quantification of Gingival Tissue Reveals Proteome Dynamics during the Initiation and Progression of Inflammatory Periodontal Disease.
Bao, Proteomics 2020 - “...2.09E-05 6.76E-03 P31725 Protein S100-A9 18 5.18 1.05E-04 9.45E-03 P08071 Lactotransferrin 17 4.86 9.88E-04 3.01E-02 Q9JHW9 Aldehyde dehydrogenase family 1 member A3 7 4.5 8.42E-04 2.77E-02 P27005 Protein S100-A8 5 4.47 2.96E-04 1.65E-02 P51437 Cathelicidin antimicrobial peptide 2 4.33 1.11E-04 9.45E-03 O08692 Neutrophilic granule protein 9...”
Q5R6B5 Aldehyde dehydrogenase X, mitochondrial from Pongo abelii
38% identity, 91% coverage
- Comparative genomics, molecular evolution and computational modeling of ALDH1B1 and ALDH2
Jackson, Chemico-biological interactions 2013 - “...1 (+ve) 1551 57,265 na 117 71 98 64 Orangutan Pongo abelii 1B1 NM_001134104 CR860576 Q5R6B5 517 9:23,179,16323,180,713 1 (ve) 1551 57,261 na 117 71 98 64 Gibbon Nomascus leucogenys 1B1 XP_003263524 a na na inc GL397291:19,434,44319,436,340 ^ 1 (ve) inc inc na 117 71 98...”
SC1052 4-hydroxyphenylacetate catabolism from Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67
36% identity, 97% coverage
- Characterization of the Caulobacter crescentus flbF promoter and identification of the inferred FlbF product as a homolog of the LcrD protein from a Yersinia enterocolitica virulence plasmid
Sanders, Journal of bacteriology 1992 - “...University of California, Berkeley Strains C. crescentus CB15 SC1052 SC1032 SC1061 SC1132 E. coli HB101 DH5a RZ1032 Relevant characteristic 32P labeled with...”
- Ntr-like promoters and upstream regulatory sequence ftr are required for transcription of a developmentally regulated Caulobacter crescentus flagellar gene
Mullin, Journal of bacteriology 1989 - “...phage or Bacterial strains C. crescentus CB15 SC511 SC1052 SC1132 E. coli HB101 JM107 CJ236 Plasmids pUC19 pUC18 pUC19603 pUC19285 pRK290 pRK2L1 pRK2L1-603...”
- “...the transcripts could be detected in flaO mutant strain SC1052 (lane C) or flbF mutant strain SC1132 (lane D). Therefore,flbG andflaN are on plasmid PRK2L1-603...”
- Use of pulsed field gel electrophoresis and transposon mutagenesis to estimate the minimal number of genes required for motility in Caulobacter crescentus
Ely, Genetics 1989 - “...- 1 6 6 )SC1042 , (pa601), SC1043 (flu-616), SC1045 (flu-169), SC1049 (fluN616), SC1052 (flb0172), SC1054 ( f l ~ - 1 7 3 )SC1060 , ( f l ~ - 1 7 6 )SC1061 , (...”
- Promoter mapping and cell cycle regulation of flagellin gene transcription in Caulobacter crescentus
Minnich, Proceedings of the National Academy of Sciences of the United States of America 1987 - “...deletion mutant]; 5, strain SC1032; 6, strain SC1052 (flaO172::TN5, a mutation in transcription unit III; ref. 9). (C) P27 [640-bp HindIII(a)-EcoRI(a)...”
- “...CB15; 4, strain PC7081; 5, strain SC1032; 6, strain SC1052. The sizes of the S1-resistant DNA fragments were determined by electrophoresis on a 4% denaturing...”
- Physical mapping and complementation analysis of transposon Tn5 mutations in Caulobacter crescentus: organization of transcriptional units in the hook gene cluster
Ohta, Journal of bacteriology 1984 - “...SC511 SC1028 SC1032 SC1038 SC1042 SC1043 SC1045 SC1049 SC1052 SC1054 SC1060 SC1061 SC1062 SC1114 SC1132 SC1134 SC1135 SC1166 SC1582 SC1585 SC1721 PC5001 PC5005...”
F7HB04 10-formyltetrahydrofolate dehydrogenase from Macaca mulatta
38% identity, 49% coverage
4pz2B / W8SZG1 Structure of zm aldh2-6 (rf2f) in complex with NAD (see paper)
40% identity, 95% coverage
- Ligand: nicotinamide-adenine-dinucleotide (4pz2B)
Q8CNI5 Putative aldehyde dehydrogenase SE_1720 from Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)
Q5HMA0 Putative aldehyde dehydrogenase SERP1729 from Staphylococcus epidermidis (strain ATCC 35984 / DSM 28319 / BCRC 17069 / CCUG 31568 / BM 3577 / RP62A)
SERP1729 aldehyde dehydrogenase from Staphylococcus epidermidis RP62A
37% identity, 97% coverage
- The Extracellular Vesicles from the Commensal Staphylococcus Epidermidis ATCC12228 Strain Regulate Skin Inflammation in the Imiquimod-Induced Psoriasis Murine Model
Gómez-Chávez, International journal of molecular sciences 2021 - “...beta C Q8CS25 COG1866 pckA Phosphoenolpyruvate carboxykinase (ATP) C Q8PCP2 COG1048 acnA Aconitate hydratase1 C Q8CNI5 COG1012 - Aldehyde dehydrogenase (NAD) family protein C Q8CNJ1 COG0356 atpA ATP synthase subunit alpha C Q8CN24 COG1012 aldA Aldehyde dehydrogenase (NAD) family protein C Q8CQB2 COG0371 gldA Glycerol dehydrogenase...”
- Phenotypic Modulation of Biofilm Formation in a Staphylococcus epidermidis Orthopedic Clinical Isolate Grown Under Different Mechanical Stimuli: Contribution From a Combined Proteomic Study
Bottagisio, Frontiers in microbiology 2020 - “...Q5HM69 Glutaminefructose-6-phosphate aminotransferase (0.0000149) GLMS_STAEQ Q5HM69 Glutaminefructose-6-phosphate aminotransferase (0.00177) NAGB_STAEQ Q5HRH8 Glucosamine-6-phosphate deaminase (0.00333) ALD1_STAEQ Q5HMA0 Aldehyde dehydrogenase SERP1729 (0.00172) A0A2G7HXB3_STAEP A0A2G7HXB3 NADP-dependent oxidoreductase (0.0000188) Q5HL33_STAEQ Q5HL33 Alpha-acetolactate decarboxylase (0.000513) BUTA_STAEQ Q5HKG6 Diacetyl reductase [(S)-acetoin forming] (0.00847) Q5HP34_STAEQ Q5HP34 Dihydrolipoyl dehydrogenase (0.0000481) Y1888_STAEQ Q5HLU4 Putative 2-hydroxyacid...”
- Proteomic Analysis Reveals a Biofilm-Like Behavior of Planktonic Aggregates of Staphylococcus epidermidis Grown Under Environmental Pressure/Stress
Bottagisio, Frontiers in microbiology 2019 - “...trend toward carbohydrate degradation. Moreover, the overexpression of putative aldehyde dehydrogenase SERP1729 ( SERP1729 gene, Q5HMA0), alcohol dehydrogenase ( SERP0257 gene, Q8CQ56), and zinc-type alcohol dehydrogenase-like protein SERP1785 ( SERP1785 gene, Q5HM44) strongly support the previous finding of anaerobic bacterial growth, besides the initial aerobic culture...”
- Concentration-Dependent Global Quantitative Proteome Response of Staphylococcus epidermidis RP62A Biofilms to Subinhibitory Tigecycline
Sung, Cells 2022 - “...46 , 47 ]. Our proteome data showed that levels of putative aldehyde dehydrogenase (AldA, SERP1729) and NADH:flavin oxidoreductase/fumarate reductase (SERP2381) expressed in strain RP62A biofilms were altered under sublethal TC pressure. Interestingly, several antibiotic resistance proteins, ErmA-1, FolA-2, Aac-aphD, Rho, MecA, IleS, and MprF exhibited...”
- Phenotypic Modulation of Biofilm Formation in a Staphylococcus epidermidis Orthopedic Clinical Isolate Grown Under Different Mechanical Stimuli: Contribution From a Combined Proteomic Study
Bottagisio, Frontiers in microbiology 2020 - “...(0.0000149) GLMS_STAEQ Q5HM69 Glutaminefructose-6-phosphate aminotransferase (0.00177) NAGB_STAEQ Q5HRH8 Glucosamine-6-phosphate deaminase (0.00333) ALD1_STAEQ Q5HMA0 Aldehyde dehydrogenase SERP1729 (0.00172) A0A2G7HXB3_STAEP A0A2G7HXB3 NADP-dependent oxidoreductase (0.0000188) Q5HL33_STAEQ Q5HL33 Alpha-acetolactate decarboxylase (0.000513) BUTA_STAEQ Q5HKG6 Diacetyl reductase [(S)-acetoin forming] (0.00847) Q5HP34_STAEQ Q5HP34 Dihydrolipoyl dehydrogenase (0.0000481) Y1888_STAEQ Q5HLU4 Putative 2-hydroxyacid dehydrogenase (0.0000504) EFG_STAEQ...”
- Proteomic Analysis Reveals a Biofilm-Like Behavior of Planktonic Aggregates of Staphylococcus epidermidis Grown Under Environmental Pressure/Stress
Bottagisio, Frontiers in microbiology 2019 - “...metabolism and an overall trend toward carbohydrate degradation. Moreover, the overexpression of putative aldehyde dehydrogenase SERP1729 ( SERP1729 gene, Q5HMA0), alcohol dehydrogenase ( SERP0257 gene, Q8CQ56), and zinc-type alcohol dehydrogenase-like protein SERP1785 ( SERP1785 gene, Q5HM44) strongly support the previous finding of anaerobic bacterial growth, besides...”
FRAAL0200 NAD+-dependent aldehyde dehydrogenase from Frankia alni ACN14a
37% identity, 91% coverage
NP_001257293 cytosolic 10-formyltetrahydrofolate dehydrogenase isoform 1 from Homo sapiens
39% identity, 51% coverage
- Abnormal downregulation of 10-formyltetrahydrofolate dehydrogenase promotes the progression of oral squamous cell carcinoma by activating PI3K/Akt/Rb pathway.
Qu, Cancer medicine 2023 - GeneRIF: Abnormal downregulation of 10-formyltetrahydrofolate dehydrogenase promotes the progression of oral squamous cell carcinoma by activating PI3K/Akt/Rb pathway.
- One-carbon metabolizing enzyme ALDH1L1 influences mitochondrial metabolism through 5-aminoimidazole-4-carboxamide ribonucleotide accumulation and serine depletion, contributing to tumor suppression.
Sasaki, Scientific reports 2023 - GeneRIF: One-carbon metabolizing enzyme ALDH1L1 influences mitochondrial metabolism through 5-aminoimidazole-4-carboxamide ribonucleotide accumulation and serine depletion, contributing to tumor suppression.
- Genetic variants in ALDH1L1 and GLDC influence the serine-to-glycine ratio in Hispanic children.
Krupenko, The American journal of clinical nutrition 2022 - GeneRIF: Genetic variants in ALDH1L1 and GLDC influence the serine-to-glycine ratio in Hispanic children.
- Modeling of interactions between functional domains of ALDH1L1.
Horita, Chemico-biological interactions 2017 - GeneRIF: The three functional domains of ALDH1L1 was defined positions of the 4'-phosphopantetheine arm within the two catalytic domains and to predict N-terminal:intermediate and intermediate:C-terminal domain interfaces.
- ALDH1L1 variant rs2276724 and mRNA expression predict post-operative clinical outcomes and are associated with TP53 expression in HBV-related hepatocellular carcinoma.
Zhu, Oncology reports 2017 - GeneRIF: Our results suggest that ALDH1L1 may be a biomarker for predicting postoperative clinical outcomes. Moreover, ALDH1L1-rs2276724 and mRNA expression were associated with TP53 expression in HBV-related hepatocellular carcinoma patients
- Association between ALDH1L1 gene polymorphism and neural tube defects in the Chinese Han population.
Wu, Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2016 (PubMed)- GeneRIF: The polymorphic loci rs4646733, rs2305225, and rs2276731 in the ALDH1L1 gene maybe potential risk factors for neural tube defects in the Chinese population.
- Mining distinct aldehyde dehydrogenase 1 (ALDH1) isoenzymes in gastric cancer.
Shen, Oncotarget 2016 - GeneRIF: high transcription activities of ALDH1A2, ALDH1A3 and ALDH1L1 predicted worsen overall survival in gastric cancer patients
- Aldehyde dehydrogenase inhibition combined with phenformin treatment reversed NSCLC through ATP depletion.
Kang, Oncotarget 2016 - GeneRIF: ALDH1L1 has a role in response to the combined treatment of gossypol and phenformin in non-small cell lung cancer
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ALDH1L1 / O75891 10-formyltetrahydrofolate dehydrogenase 1 (EC 3.5.1.10; EC 1.5.1.6) from Homo sapiens (see 7 papers)
AL1L1_HUMAN / O75891 Cytosolic 10-formyltetrahydrofolate dehydrogenase; 10-FTHFDH; FDH; Aldehyde dehydrogenase family 1 member L1; EC 1.5.1.6 from Homo sapiens (Human) (see 3 papers)
O75891 formyltetrahydrofolate dehydrogenase (EC 1.5.1.6) from Homo sapiens (see paper)
39% identity, 52% coverage
- function: Cytosolic 10-formyltetrahydrofolate dehydrogenase that catalyzes the NADP(+)-dependent conversion of 10-formyltetrahydrofolate to tetrahydrofolate and carbon dioxide (PubMed:19933275, PubMed:21238436). May also have an NADP(+)-dependent aldehyde dehydrogenase activity towards formaldehyde, acetaldehyde, propionaldehyde, and benzaldehyde (By similarity).
catalytic activity: (6R)-10-formyltetrahydrofolate + H2O + NADP(+) = (6S)-5,6,7,8- tetrahydrofolate + CO2 + H(+) + NADPH (RHEA:10180)
subunit: Homotetramer. - Proteomic association with age-dependent sex differences in Wisconsin Card Sorting Test performance in healthy Thai subjects
Chen, Scientific reports 2023 - “...NDUFS1 NADH-ubiquinone oxidoreductase 75kDa subunit, mitochondrial 4.06335 0.00375275 39 P01042 KNG1 Kininogen-1 5.17065 0.00387168 40 O75891 ALDH1L1 Cytosolic 10-formyltetrahydrofolate dehydrogenase 3.43624 0.00418803 41 P01008 SERPINC1 Antithrombin-III 4.40148 0.00418803 42 P36955 SERPINF1 Pigment epithelium-derived factor 4.6215 0.00424301 43 P14652 HOXB2 Homeobox protein Hox-B2 2.88034 0.00549476 44 P10412...”
- Distinct or Overlapping Areas of Mitochondrial Thioredoxin 2 May Be Used for Its Covalent and Strong Non-Covalent Interactions with Protein Ligands.
Ntallis, Antioxidants (Basel, Switzerland) 2023 - “...Cytochrome b-c1 complex subunit 1, mitochondrial 5xte (chain K) 6.69 2j0fAC 7.9 1500 C 29 O75891 Cytosolic 10-formyltetra-hydrofolate dehydrogenase AF 5.45 3zymAB 9.8 60 C 30 O75828 Carbonyl reductase [NADPH] 3 2HRB (chain A) 5.45 1jmuFG 8.4 640 C 31 P49411 Elongation factor Tu, mitochondrial, EF-Tu...”
- Proteomic Analysis in Valvular Cardiomyopathy: Aortic Regurgitation vs. Aortic Stenosis.
Holst, Cells 2023 - “...Q5T0D9 TPRG1L Tumor protein p63-regulated gene 1-like protein 0.050 Q16881 TXNRD1 Thioredoxin reductase 1 0.054 O75891 ALDH1L1 Cytosolic 10-formyltetrahydrofolate dehydrogenase 0.024 Q99766 ATP5S/DMAC2L ATP synthase subunit s, mitochondrial 0.049 * p -values calculated by the glm function of the stats package in R using LFQ protein...”
- Characterization of human oxidoreductases involved in aldehyde odorant metabolism.
Boichot, Scientific reports 2023 - “...8 (15, 10, 1) Sepiapterin reductase P35270 11 (15, 11, 0) Cytosolic 10-formyltetrahydrofolate dehydrogenase (ALDH1L1) O75891 3 (13, 11, 1) Quinone oxidoreductase Q08257 8 (10, 10, 0) Isocitrate dehydrogenase [NADP], mitochondrial P48735 10 (5, 14, 0) Alcohol dehydrogenase 1A (ADH1A) P07327 16 (9, 7, 1) Dihydropteridine...”
- Interplay between Cultured Human Osteoblastic and Skeletal Muscle Cells: Effects of Conditioned Media on Glucose and Fatty Acid Metabolism.
Lunde, Biomedicines 2023 - “...1 0.025562 0.01318 P35914 HMGCL 3-hydroxy-3-methylglutaryl-CoA lyase 0.0276 0.010166 Q99798 ACO2 Aconitase 2 0.010616 0.025911 O75891 ALDH1L1 Aldehyde dehydrogenase 1 family member L1 0.029607 0.004703 P54886 ALDH18A Aldehyde dehydrogenase 18 family member A1 0.014905 0.048835 P05091 ALDH2 Aldehyde dehydrogenase 2 family member 0.027491 0.006844 Q9Y2R0 COA3...”
- A Detoxification Enzyme for Apis mellifera Newly Characterized by Recombinant Expression: 10-Formyl Tetrahydrofolate Dehydrogenase
Mating, Frontiers in insect science 2022 - “...Pongo abllei , and Mus musculus amino acid sequences were retrieved from uniprot.org (Accesion Nr: O75891, P28037, Q5RFM9, Q8R0Y6), and predicted amino acid sequences of A. mellifera was retrieved from NCBI (Accesion Nr.: XP_026298140.1). A protein similarity summary was generated based on the DNA sequence of...”
- Insight into the Molecular Signature of Skeletal Muscle Characterizing Lifelong Football Players
Orrù, International journal of environmental research and public health 2022 - “...delta CCT4 3.43 Q8NBN7 Retinol dehydrogenase 13 RDH13 3.43 Q5HYK3 2-Methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial COQ5 3.43 O75891 Cytosolic 10-formyltetrahydrofolate dehydrogenase ALDH1L1 3.43 P11532 Dystrophin DMD 3.43 O95182 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 7 NDUFA7 3.07 Q9UFN0 Protein NipSnap homolog 3A NIPSNAP3A 3.07 P55039 Developmentally regulated...”
- Proteomic Signatures of Human Visceral and Subcutaneous Adipocytes
Hruska, The Journal of clinical endocrinology and metabolism 2022 - “...Transferrin receptor protein 1 TFRC -2.39 6.09E-05 Q8N6C5 Immunoglobulin superfamily member 1 IGSF1 -2.45 4.60E-06 O75891 Cytosolic 10-formyltetrahydrofolate dehydrogenase ALDH1L1 -2.46 2.54E-12 O95671 N-acetylserotonin O-methyltransferase-like protein ASMTL -2.48 1.60E-04 P27487 Dipeptidyl peptidase 4 DPP4 -2.58 3.41E-05 P21810 Biglycan BGN -2.61 3.15E-05 P51888 Prolargin PRELP -2.64 4.22E-04...”
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LOC18031917 succinate-semialdehyde dehydrogenase, mitochondrial from Citrus x clementina
36% identity, 90% coverage
- Transcriptome analysis of the pulp of citrus fruitlets suggests that domestication enhanced growth processes and reduced chemical defenses increasing palatability
Perez-Roman, Frontiers in plant science 2022 - “...GAD5 (LOC18046053 and LOC18052541, EC:4.1.1.15), butyrate pyruvate transaminase, POP2 (LOC18039191, EC:2.6.1.96) and succinate-semialdehyde dehydrogenase, SSADH (LOC18031917, EC:1.2.1.24), that together make up the GABA shunt, showed the same tendency ( Supplementary Figure 4.021 ). The conversion of glutamate to glutamine (LOC18044424, EC:6.3.1.2) and pyrroline-carboxylate (LOC18045924, EC:1.2.1.88) also...”
XP_002939310 aldehyde dehydrogenase family 1 member A3 from Xenopus tropicalis
39% identity, 92% coverage
SPSK_00262 aldehyde dehydrogenase (NAD+) from Sporothrix schenckii 1099-18
38% identity, 95% coverage
KPHS_06330 4-hydroxyphenylacetate catabolism from Klebsiella pneumoniae subsp. pneumoniae HS11286
36% identity, 97% coverage
- Use of a combined antibacterial synergy approach and the ANNOgesic tool to identify novel targets within the gene networks of multidrug-resistant Klebsiella pneumoniae
Lee, mSystems 2024 - “...( D ) Tyrosine metabolism. The gross pattern of tyrosine metabolism decreased under combination treatment. KPHS_06330 (4-hydroxyphenlacetate catabolism) and KPHS_06260 (4-hydroxyphenlacetate catabolism) were remarkably enhanced in the colistin-only single-treatment condition. Both genes participated in 4-hydroxypenylacetate catabolism, including phenylacetate breakdown. ( E ) Carbon metabolism. Expression of...”
- “...are functionally connected with KPHS_01080, which is associated with the cobalamin riboswitch. ( D ) KPHS_06330, KPHS_23680 (bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase), KPHS_06340 (4-hydroxyphenlacetate degradation bifunctional isomerase/decarboxylase C-terminal subunit), KPHS_06310 (4-hydroxyphenlacetate catabolism), and KPHS_06350 (4-hydroxyphenlacetate catabolism) are linked in a functional network. ( E ) According to...”
gabD / Q4KKA2 NAD(P)-dependent succinate-semialdehyde dehydrogenase (EC 1.2.1.16) from Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5) (see paper)
35% identity, 99% coverage
Q5RF00 Aldehyde dehydrogenase, mitochondrial from Pongo abelii
NP_001124747 aldehyde dehydrogenase, mitochondrial precursor from Pongo abelii
39% identity, 90% coverage
- Comparative genomics, molecular evolution and computational modeling of ALDH1B1 and ALDH2
Jackson, Chemico-biological interactions 2013 - “...(+ve) * 21,456 56,283 na 124 99 72 68 Orangutan Pongo abelii 2 NP_001124747 na Q5RF00 517 12:113,595,100113,634,788 13 (+ve) 39,689 56,381 na 125 99 72 68 Gibbon Nomascus leucogenys 2 XP_003274503 a na na 517 GL397363:46,368133,282 13 (+ve) 86,915 56,333 na 125 99 71 67...”
- Comparative genomics, molecular evolution and computational modeling of ALDH1B1 and ALDH2
Jackson, Chemico-biological interactions 2013 - “...12:112,226,948112,248,403 13 (+ve) * 21,456 56,283 na 124 99 72 68 Orangutan Pongo abelii 2 NP_001124747 na Q5RF00 517 12:113,595,100113,634,788 13 (+ve) 39,689 56,381 na 125 99 72 68 Gibbon Nomascus leucogenys 2 XP_003274503 a na na 517 GL397363:46,368133,282 13 (+ve) 86,915 56,333 na 125 99...”
rrnAC2473 aldehyde dehydrogenase from Haloarcula marismortui ATCC 43049
36% identity, 88% coverage
- Genome information management and integrated data analysis with HaloLex
Pfeiffer, Archives of microbiology 2008 - “...OE4360R, HQ3733A rrnAC2460 1,977 2,127 Shortened NP1264A, HQ3402A, OE4140R rrnAC2469 1,299 1,422 Shortened HQ2809A, HQ2192A rrnAC2473 1,524 1,569 Shortened OE2133R, NP3020A rrnAC2474 288 351 Shortened NP1258A, OE4136R, HQ3399A rrnAC2476 936 582 Extended NP1312A, OE4133R rrnAC2518 1,266 1,221 Extended NP1318A, OE3943R, HQ3056A rrnAC2525 1,026 735 Extended HQ1021A,...”
4fr8C / P05091 Crystal structure of human aldehyde dehydrogenase-2 in complex with nitroglycerin (see paper)
39% identity, 94% coverage
- Ligand: nicotinamide-adenine-dinucleotide (4fr8C)
LOC116940317 retinal dehydrogenase 2-like from Petromyzon marinus
39% identity, 91% coverage
BRA1161 5-carboxy-2-hydroxymuconate semialdehyde dehydrogenase from Brucella suis 1330
39% identity, 93% coverage
CwatDRAFT_0842 Aldehyde dehydrogenase (NAD+) from Crocosphaera watsonii WH 8501
39% identity, 95% coverage
- Bioinformatic evaluation of L-arginine catabolic pathways in 24 cyanobacteria and transcriptional analysis of genes encoding enzymes of L-arginine catabolism in the cyanobacterium Synechocystis sp. PCC 6803
Schriek, BMC genomics 2007 - “...Synechococcus sp. RS 9917 RS9917_06190 RS9917_02041, RS9917_05240 RS9917_02641 Crocosphaera watsonii WH 8501 n.d. CwatDRAFT_5161 CwatDRAFT_0865, CwatDRAFT_0842, CwatDRAFT_0969 Trichodesmium erythraeum IMS 101 TeryDRAFT_4567 TeryDRAFT_3251 TeryDRAFT_2672 TeryDRAFT_3296, TeryDRAFT_3923 Freshwater species Synechococcus elongatus sp. PCC 6301 n.d. Syc0599_c, Syc1466_c Syc1030_d Synechococcus elongatus sp. PCC 7942 n.d. Synpcc7942_0943, Synpcc7942_0031 Synpcc7942_0489...”
- “...Synechococcus sp. RS 9917 n.d. RS9917_02041, RS9917_05240 RS9917_02641 Crocosphaera watsonii WH 8501 CwatDRAFT_0830 CwatDRAFT_5161 CwatDRAFT_0865, CwatDRAFT_0842, CwatDRAFT_0969 Trichodesmium erythraeum IMS 101 TeryDRAFT_2282 TeryDRAFT_3251 TeryDRAFT_2672 TeryDRAFT_3296, TeryDRAFT_3923 Freshwater species Synechococcus elongatus sp. PCC 6301 n.d. Syc0599_c, Syc1466_c Syc1030_d Synechococcus elongatus sp. PCC 7942 n.d. Synpcc7942_0943, Synpcc7942_0031 Synpcc7942_0489...”
ALDH2 / P05091 mitochondrial aldehyde dehydrogenase subunit (EC 1.2.1.3; EC 1.2.1.39) from Homo sapiens (see 14 papers)
ALDH2_HUMAN / P05091 Aldehyde dehydrogenase, mitochondrial; ALDH class 2; ALDH-E2; ALDHI; EC 1.2.1.3 from Homo sapiens (Human) (see 3 papers)
P05091 aldehyde dehydrogenase (NAD+) (EC 1.2.1.3) from Homo sapiens (see 13 papers)
NP_000681 aldehyde dehydrogenase, mitochondrial isoform 1 precursor from Homo sapiens
39% identity, 90% coverage
- function: Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage.
catalytic activity: an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH (RHEA:16185)
subunit: Homotetramer - Identification of inhibitors from a functional food-based plant Perillae Folium against hyperuricemia via metabolomics profiling, network pharmacology and all-atom molecular dynamics simulations
Wu, Frontiers in endocrinology 2024 - “...ZH02 P08254 MMP3 Intersected target -2151.6 -6.56 ZH03 P21397 MAOA Intersected target -2128.7 -6.49 ZH04 P05091 ALDH2 Intersected target -1975.6 -6.02 ZH05 P45983 MAPK8 Intersected target -2037.3 -6.21 ZH06 Q14790 CASP8 Intersected target -1903.8 -5.8 ZH07 P37231 PPARG Intersected target -1907.6 -5.82 ZH08 Q04206 RELA Intersected...”
- Exploring the effective compounds and potential mechanisms of Shengxian Decoction against coronary heart disease by UPLC-Q-TOF/MS and network pharmacology analysis
Zhou, Heliyon 2024 - “...Gamma-aminobutyric acid type B receptor subunit 1 Q9UBS5 GABBR1 2 0 T95 Aldehyde dehydrogenase, mitochondrial P05091 ALDH2 3 0 T96 Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO 1 0 3.4 C-T-D network construction and CI analysis A C-T-D network was constructed by the Cytoscape 3.8.2 software to facilitate...”
- Impact of a Functional Dairy Powder and Its Primary Component on the Growth of Pathogenic and Probiotic Gut Bacteria and Human Coronavirus 229E.
Dang, International journal of molecular sciences 2024 - “...motif-containing protein_ mitochondrial 1.09 P12109 COL6A1 Collagen alpha-1chain 1.07 Q12841 FSTL1 Follistatin-related protein 1 1.07 P05091 ALDH2 Aldehyde dehydrogenase_ mitochondrial 1.05 P29966 MARCKS Myristoylated alanine-rich C-kinase substrate 1.05 P06756 ITGAV Integrin alpha V 1.04 Q13308 PTK7 Inactive tyrosine-protein kinase 7 1.04 Q9Y570 PPME1 Protein phosphatase methylesterase...”
- Comparative Proteomic Analysis of Type 2 Diabetic versus Non-Diabetic Vitreous Fluids.
Alanazi, Life (Basel, Switzerland) 2024 - “...Adhesion G protein-coupled receptor B3 ADGRB3 0.015424 4 O60333 Kinesin-like protein KIF1B KIF1B 0.045349 5 P05091 Aldehyde dehydrogenase, mitochondrial ALDH2 0.002538 6 P27487 Dipeptidyl peptidase 4 DPP4 0.049516 7 Q3LXA3 Triokinase/FMN cyclase TKFC 0.034098 8 Q86YR5 G-protein-signaling modulator 1 GPSM1 0.048014 9 Q9UL18 Protein argonaute-1 AGO1...”
- Novel Genetic and Biochemical Insights into the Spectrum of NEFL-Associated Phenotypes.
Della, Journal of neuromuscular diseases 2024 - “...mitochondrial (CH60_HUMAN) 1.80 0.002 P49821 4 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (NDUV1_HUMAN) 1.79 0.016 P05091 3 Aldehyde dehydrogenase, mitochondrial (ALDH2_HUMAN) 1.79 0.015 P30048 6 Thioredoxin-dependent peroxide reductase, mitochondrial (PRDX3_HUMAN) 1.75 0.013 P00505 17 Aspartate aminotransferase, mitochondrial (AATM_HUMAN) 1.66 0.001 P10412 7 Histone H1.4 (H14_HUMAN) 1.65...”
- A Network Pharmacology Method Combined with Molecular Docking Verification to Explore the Therapeutic Mechanisms Underlying Simiao Pill Herbal Medicine against Hyperuricemia
Qian, BioMed research international 2023 - “...P01138 74 COG2 Q14746 35 LCN2 P80188 75 TNFRSF11B O00300 36 NPPA P01160 76 ALDH2 P05091 37 NPPB P16860 77 G6PD P11413 38 HNF1A P20823 78 IL6R P08887 39 HNF4A P41235 79 IL18 Q14116 40 NFATC1 O95644 80 SLC6A3 Q01959 Table 2 Top 5 enriched BP,...”
- The mitotic surveillance pathway requires PLK1-dependent 53BP1 displacement from kinetochores
Burigotto, 2023 - Comprehensive proteomic analysis of autophagosomes derived from Leishmania-infected macrophages
Nandan, PloS one 2023 - “...1.138326 LIPA P38571 Lysosomal acid lipase/cholesteryl ester hydrolase 1.059779 ASPH Q12797 Aspartyl/asparaginyl beta-hydroxylase 1.031428 ALDH2 P05091 Aldehyde dehydrogenase, mitochondrial -1.09031 SOD2 P04179 Superoxide dismutase [Mn], mitochondrial -1.11184 STMN1 P16949 Stathmin -1.12842 LAPTM5 Q13571 Lysosomal-associated transmembrane protein 5 -1.24044 NDUFA4 O00483 Cytochrome c oxidase subunit NDUFA4 -1.52182...”
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- ALDH2: Essential Mediator for the Remote Ischemic Conditioning Strategy to Reduce Myocardial Ischemia/Reperfusion Injury.
Zhu, Journal of cardiovascular translational research 2024 (PubMed)- GeneRIF: ALDH2: Essential Mediator for the Remote Ischemic Conditioning Strategy to Reduce Myocardial Ischemia/Reperfusion Injury.
- Changes of neurofilament light chain in patients with alcohol dependence following withdrawal and the genetic effect from ALDH2 Polymorphism.
Huang, European archives of psychiatry and clinical neuroscience 2024 - GeneRIF: Changes of neurofilament light chain in patients with alcohol dependence following withdrawal and the genetic effect from ALDH2 Polymorphism.
- Activation of mitochondrial aldehyde dehydrogenase 2 promotes hair growth in human hair follicles.
Lee, Journal of advanced research 2024 - GeneRIF: Activation of mitochondrial aldehyde dehydrogenase 2 promotes hair growth in human hair follicles.
- ALDH2 deficiency exacerbates MCD-diet induced MASLD by modulating bile acid metabolism.
Luo, Free radical biology & medicine 2024 (PubMed)- GeneRIF: ALDH2 deficiency exacerbates MCD-diet induced MASLD by modulating bile acid metabolism.
- Aldehyde Dehydrogenase 2 (ALDH2) rs671 Polymorphism is a Predictor of Pulmonary Hypertension Due to Left Heart Disease.
Tang, Heart, lung & circulation 2024 (PubMed)- GeneRIF: Aldehyde Dehydrogenase 2 (ALDH2) rs671 Polymorphism is a Predictor of Pulmonary Hypertension Due to Left Heart Disease.
- ALDH2 is a novel biomarker and exerts an inhibitory effect on melanoma.
Lei, Scientific reports 2024 - GeneRIF: ALDH2 is a novel biomarker and exerts an inhibitory effect on melanoma.
- Exploring patterns of alcohol use and alcohol use disorder among Asian Americans with a finer lens.
Zhang, Drug and alcohol dependence 2024 (PubMed)- GeneRIF: Exploring patterns of alcohol use and alcohol use disorder among Asian Americans with a finer lens.
- Research Progress on the Correlation between Acetaldehyde Dehydrogenase 2 and Hepatocellular Carcinoma Development.
Yang, The Journal of pharmacology and experimental therapeutics 2024 (PubMed)- GeneRIF: Research Progress on the Correlation between Acetaldehyde Dehydrogenase 2 and Hepatocellular Carcinoma Development.
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ALD5 / P40047 aldehyde dehydrogenase, mitochondrial (EC 1.2.1.4; EC 1.2.1.3) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see paper)
ALDH5_YEAST / P40047 Aldehyde dehydrogenase 5, mitochondrial; EC 1.2.1.-; EC 1.2.1.4 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 6 papers)
NP_010996 aldehyde dehydrogenase (NAD(P)(+)) ALD5 from Saccharomyces cerevisiae S288C
37% identity, 90% coverage
- function: Minor mitochondrial aldehyde dehydrogenase isoform. Plays a role in regulation or biosynthesis of electron transport chain components. Involved in the biosynthesis of acetate during anaerobic growth on glucose.
catalytic activity: acetaldehyde + H2O + NADP(+) = acetate + 2 H(+) + NADPH (RHEA:25298)
catalytic activity: H2O + NADP(+) + propanal = 2 H(+) + NADPH + propanoate (RHEA:27918)
catalytic activity: H2O + NAD(+) + propanal = 2 H(+) + NADH + propanoate (RHEA:67256) - Mitochondrial NAD dependent aldehyde dehydrogenase either from yeast or human replaces yeast cytoplasmic NADP dependent aldehyde dehydrogenase for the aerobic growth of yeast on ethanol.
Mukhopadhyay, Biochimica et biophysica acta 2013 - GeneRIF: Mitochondrial NAD dependent aldehyde dehydrogenase either from yeast or human replaces yeast cytoplasmic NADP dependent aldehyde dehydrogenase for the aerobic growth of yeast on ethanol.
- Two sources of mitochondrial NADPH in the yeast Saccharomyces cerevisiae.
Miyagi, The Journal of biological chemistry 2009 - GeneRIF: there are two sources of mitochondrial NADPH in yeast: one is the mitochondrial Pos5p-NADH kinase reaction and the other is the mitochondrial Pos5p-NAD kinase reaction followed by the mitochondrial NADP(+)-dependent acetaldehyde dehydrogenase reaction.
- Fatty aldehyde dehydrogenase multigene family involved in the assimilation of n-alkanes in Yarrowia lipolytica
Iwama, The Journal of biological chemistry 2014 - “...Ald2p (P47771), Ald3p (P54114), Ald4p (P46367), Ald5p (P40047), and Hfd1p (Q04458) of S. cerevisiae, and YALI0E00264p (Q6C7J6), YALI0C03025p (Q6CD79),...”
Q0QHK6 1-pyrroline-5-carboxylate dehydrogenase 2 from Glossina morsitans morsitans
38% identity, 89% coverage
NP_010996, YER073W Ald5p from Saccharomyces cerevisiae
37% identity, 90% coverage
- Furfural tolerance of mutant Saccharomyces cerevisiae selected via ionizing radiation combined with adaptive laboratory evolution
Ren, Biotechnology for biofuels and bioproducts 2024 - “...YGL055W OLE1 1916.41 1.99 Delta(9) fatty acid desaturase YNL071W LAT1 4.82 2.39 Dihydrolipoamide acetyltransferase component YER073W ALD5 190.66 3.85 Mitochondrial aldehyde dehydrogenase YGR256W GND2 3.82 2.69 6-Phosphogluconate dehydrogenase YGR248W SOL4 14.40 4.25 6-Phosphogluconolactonase Analysis of RT-qPCR results The 32 mutation sites related to furfural tolerance were...”
- Spt4 facilitates the movement of RNA polymerase II through the +2 nucleosomal barrier
Uzun, Cell reports 2021 - “...TEF-seq (Spt4 and Spt5) reads of example genes transcribed fromthe positive strand, namely, YER072W , YER073W , and YDR381W , in two biological replicates. The dark-blue boxes indicate the transcribed region of the genes (from TSS to PAS), and the blue line indicates the intronic region...”
- tRNA Genes Affect Chromosome Structure and Function via Local Effects
Hamdani, Molecular and cellular biology 2019 - “...chaperone Downregulated YBR068c YBR296c YCR008w YER073w YER091c YGL009c YHR208w YJR010w YJR016c 0.030966243 0.039894621 0.015662463 0.045197971 0.042003857...”
- ALD5, PAD1, ATF1 and ATF2 facilitate the catabolism of coniferyl aldehyde, ferulic acid and p-coumaric acid in Saccharomyces cerevisiae
Adeboye, Scientific reports 2017 - “...The nucleotides sequences accession numbers of the ALD5, PAD1, ATF1, ATF2 and CALDH respectively are NP_010996, DAA12367, CAA99708, CAA97203 and WP_016502080 respectively. Selection criteria for genes of interest As, we have previously proposed a pathway for the conversion of coniferyl aldehyde, ferulic acid and p-coumaric acid...”
- “...ALD2-ALD6. ALD6 (YPL061w), ALD2 (YMR170c) and ALD3 (YMR169c) are cytosolic, while ALD4 (YOR374w) and ALD5 (YER073w) are mitochondrial 19 . The ALD genes have also been reported to exhibit redundancy, although they use different co-factors 19 20 . The redundancy in the ALD gene family may...”
- Different specificities of two aldehyde dehydrogenases from Saccharomyces cerevisiae var. boulardii
Datta, Bioscience reports 2017 - “...enzymes. ALD2 ( YMR170C ), ALD3 ( YMR169C ), ALD4 ( YOR374W ), ALD5 ( YER073W ) and ALD6 ( YPL061W ) are the five different gene products identified in these categories [ 19 , 20 ]. Two cytosolic (Ald2p and Ald3p) and one mitochondrial (Ald5p)...”
- Dynamic identifying protein functional modules based on adaptive density modularity in protein-protein interaction networks
Shen, BMC bioinformatics 2015 - “...translation q0140 yal041w ybl090w ybr006w ybr146w ybr251w ydl045w-a ydr041w ydr124w ydr175c ydr337w ydr347w ydr494w yer050c yer073w ygl129c ygr165w ygr215w yhl004w yhr059w yil070c yil093c yjl063c yjr060w yjr101w yjr113c ykl003c ykl151c ykl155c ymr158w ymr188c ynl081c ynl137c ynl306w ynr036c ynr037c yol143c yor158w ypl013c ypl118w 5.52e-32 23 out of 36...”
- Ecological success of a group of Saccharomyces cerevisiae/Saccharomyces kudriavzevii hybrids in the northern european wine-making environment
Erny, Applied and environmental microbiology 2012 - “...YBL021C SK_YCR093w YCL014w YDL003W YDR337fw YEL061wfw YER073w (HE585129) YFR030W SK_YGL035 YGL162W YHL038c YHR043C YIL013C SK_YJL206c SK_YJL123c YJL052W YJR139c...”
- Relating perturbation magnitude to temporal gene expression in biological systems
Callister, BMC research notes 2009 - “...Phenylpyruvate decarboxylase Glycolysis YDR481C Repressible alkaline phosphatase Glycerolipid YER026C phosphatidylserine synthase Glycerolipid YER062C DL-glycerol-3-phosphatase Glycerolipid YER073W Mitochondrial aldehyde dehydrogenase Glycerolipid YER118C Transmembrane osmosensor HOG YER178W E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex Glycolysis YFL056C Putative aryl-alcohol dehydrogenase Glycerolipid YFR053C Hexokinase isoenzyme 1 Glycolysis YGL257C...”
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Entcl_3798 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase from [Enterobacter] lignolyticus SCF1
36% identity, 97% coverage
TGNE_ACIAD / Q6F9G0 Succinate semialdehyde dehydrogenase; SSA dehydrogenase; EC 1.2.1.24 from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) (see paper)
ACIAD2539 succinate-semialdehyde dehydrogenase from Acinetobacter sp. ADP1
35% identity, 98% coverage
- function: Involved in the degradation of the pyridine ring of trigonelline (TG; N-methylnicotinate) into succinate and methylamine as carbon and nitrogen sources, respectively. Catalyzes the NAD(+)- dependent oxidation of succinate semialdehyde to succinate.
catalytic activity: H2O + NAD(+) + succinate semialdehyde = 2 H(+) + NADH + succinate (RHEA:13217)
subunit: Homotetramer. - Elucidation of the trigonelline degradation pathway reveals previously undescribed enzymes and metabolites
Perchat, Proceedings of the National Academy of Sciences of the United States of America 2018 - “...to ACIAD2542-ACIAD2545 but also to the nearby ACIAD2539 and ACIAD2546 are present on a symbiotic megaplasmid in Sinorhizobium meliloti 1021 (SMa0792-SMa0796,...”
- “...the growth kinetics of mutant strains deleted for ACIAD2539, ACIAD2542-ACIAD2545, and ACIAD2546 with TG as the carbon source, the nitrogen source, or both....”
BADH_SPIOL / P17202 Aminoaldehyde dehydrogenase BADH; 4-trimethylammoniobutyraldehyde dehydrogenase BADH; Aminobutyraldehyde dehydrogenase BADH; Betaine aldehyde dehydrogenase; SoBADH; EC 1.2.1.-; EC 1.2.1.47; EC 1.2.1.19; EC 1.2.1.8 from Spinacia oleracea (Spinach) (see 5 papers)
P17202 betaine-aldehyde dehydrogenase (EC 1.2.1.8) from Spinacia oleracea (see 3 papers)
35% identity, 94% coverage
- function: Dehydrogenase innvolved in glycine betaine biosynthesis (PubMed:22345508, PubMed:2320587, PubMed:24884441). Metabolizes and detoxifies aldehyde products of polyamine degradation to non-toxic amino acids (Probable). Catalyzes the oxidation of betaine aldehyde to glycine betaine (PubMed:22345508, PubMed:24884441). Catalyzes the oxidation of 4-aminobutanal and 3-aminopropanal to 4-aminobutanoate and beta-alanine, respectively (PubMed:22345508).
catalytic activity: 4-aminobutanal + H2O + NAD(+) = 4-aminobutanoate + 2 H(+) + NADH (RHEA:19105)
catalytic activity: 3-aminopropanal + H2O + NAD(+) = beta-alanine + 2 H(+) + NADH (RHEA:30695)
catalytic activity: 4-(trimethylamino)butanal + H2O + NAD(+) = 4- (trimethylamino)butanoate + 2 H(+) + NADH (RHEA:17985)
catalytic activity: betaine aldehyde + H2O + NAD(+) = glycine betaine + 2 H(+) + NADH (RHEA:15305)
subunit: Forms homodimers. - Structural and functional analysis of betaine aldehyde dehydrogenase from Staphylococcus aureus
Halavaty, Acta crystallographica. Section D, Biological crystallography 2015 - “...Q9HTJ1; PDB entry 2wme ; Gonzlez-Segura et al. , 2009 ), So BADH (UniProtKB entry P17202; PDB entry 4a0m ; Daz-Snchez et al. , 2012 ), At BADH (UniProtKB entry Q8UH56; PDB entry 3r31 ; New York Structural Genomics Research Consortium, unpublished work) and Gm BADH...”
Q6C7J6 YALI0E00264p from Yarrowia lipolytica (strain CLIB 122 / E 150)
38% identity, 89% coverage
AFUA_7G01000, Afu7g01000 aldehyde dehydrogenase, putative from Aspergillus fumigatus Af293
37% identity, 95% coverage
- Distinct transcriptional responses to fludioxonil in Aspergillus fumigatus and its ΔtcsC and Δskn7 mutants reveal a crucial role for Skn7 in the cell wall reorganizations triggered by this antifungal
Schruefer, BMC genomics 2023 - “...and 30 down-regulated at both time points (Additional Table 3 ). The two neighbouring genes Afu7g01000 and Afu7g01010 encode a putative alcohol and a putative acetaldehyde dehydrogenase and are both strongly up-regulated at both time points (Fig. 6 A). The two flanking genes Afu7g0990 and Afu7g01020...”
- “...in the metabolism of ethanol. These genes are largely or exclusively wild type-specific FUGs and Afu7g01000 and Afu7g01010 belong to the most strongly up-regulated genes. Adh1 (Afu7g01010) is the ortholog of C.albicans Adh1, which was shown to catalyse the oxidation of methylglyoxal to pyruvate [ 20...”
- Effects of amino acids on the lignocellulose degradation by Aspergillus fumigatus Z5: insights into performance, transcriptional, and proteomic profiles
Miao, Biotechnology for biofuels 2019 - “...energy metabolism. Proteins such as acetyl-coA hydrolase (AFUA_8G05580), malate synthase (AFUA_6G03540), and aldehyde dehydrogenase (AFUA_2G00720, AFUA_7G01000) showed significant differences between the transcriptome and proteome results. The differences in mRNA and proteins between these genes indicated the post-transcriptional control mechanisms of these proteins involving, for example, protein...”
- A possible role for fumagillin in cellular damage during host infection by Aspergillus fumigatus
Guruceaga, Virulence 2018 - “...3.79 4.50 Pectin lyase Afu5g10380 3.57 3.31 C6 transcription factor Afu5g14290 4.36 1.16 Aldehyde dehydrogenase Afu7g01000 4.11 7.86 Indoleamine 2.3-dioxygenase Afu7g02010 4.19 5.94 5.72 8.21 Defensin domain protein Afu7g05180 5.06 6.71 4.81 4.21 Integral membrane protein Pth11-like Afu7g06620 3.41 4.72 3.38 4.41 a This value represents...”
- “...genes of the tyrosine degradation cluster ( hppD and maiA ) and an aldehyde dehydrogenase (Afu7g01000), a gene that is overexpressed in the presence of L-tyrosine [ 55 ], were DEGs, with a higher expression on the final day of infection. Interestingly, pyomelanin is derived by...”
- A Multifaceted Role of Tryptophan Metabolism and Indoleamine 2,3-Dioxygenase Activity in Aspergillus fumigatus-Host Interactions
Choera, Frontiers in immunology 2017 - “...Trp carboxylase AADC MaoN Afu3g00100 Monoamine oxidase MAOA AldA Ald4 Afu2g00720 Aldehyde dehydrogenase ALDH Ald5 Afu7g01000 Afu6g11430 a Prediction of protein function based on AspGD ( http://www.aspgd.org/ ) and KEGG ( http://www.genome.jp/kegg/kegg2.html ) . DAHP synthase, 3-deoxy- d -arabinoheptulosonate 7-phosphate synthase; EPSP synthase, enolpyruvylshikimate-3-phosphate synthase; AFMID,...”
- The Aspergillus fumigatus SchASCH9 kinase modulates SakAHOG1 MAP kinase activity and it is essential for virulence
Alves, Molecular microbiology 2016 - “...AFUA_8G00550 AFUB_086020 Putative methyl transferase; member of the pseurotin A gene cluster 2.742 NI NI AFUA_7G01000 AFUB_087580 Putative alcohol dehydrogenase involved in ethanol metabolism 1.659 NI NI AFUA_7G01340 AFUB_087920 Putative RPEL repeat protein NI NI 1.315 AFUA_7G06050 AFUB_091630 Ortholog(s) have SNARE binding, polyubiquitin bind- ing activity...”
- Interplay between Gliotoxin Resistance, Secretion, and the Methyl/Methionine Cycle in Aspergillus fumigatus
Owens, Eukaryotic cell 2015 - “...AFUA_2G16080 AFUA_2G12200 AFUA_7G06810 AFUA_1G16523 AFUA_2G15290 AFUA_5G09580 AFUA_7G01000 Data are sorted by fold change, in descending order. Statistical...”
- Transcriptomic and proteomic analyses of the Aspergillus fumigatus hypoxia response using an oxygen-controlled fermenter
Barker, BMC genomics 2012 - “...However, there are four additional aldehyde dehydrogenase encoding genes in A. fumigatus , Afu2g00720 and Afu7g01000 (NAD + ) and Afu4g08600 and Afu4g13500 (NAD(P) + ), so it is possible that these enzymes, and not AldA, are utilized under hypoxic conditions to metabolize ethanol. Afu4g08600 does...”
- “...transcript by 24 hours in hypoxia when ethanol levels are assumed to be higher, whereas Afu7g01000 and Afu4g13500 transcripts are reduced, although not to the same degree as aldA (Additional file 5 ). A recent proteomics study indicated that Afu7g01000 is most probably the major aldehyde...”
- The temporal dynamics of differential gene expression in Aspergillus fumigatus interacting with human immature dendritic cells in vitro
Morton, PloS one 2011 - “...ion transporter AFUA_2G05560 exonuclease AFUA_3G03640 MFS siderochrome iron transporter MirB AFUA_3G11860 microtubule associated protein EB1 AFUA_7G01000 aldehyde dehydrogenase Nucleotide/nucleoside/nucleobase binding (p: 0.042) AFUA_2G16860 MFS multidrug transporter, AFUA_4G08930 nucleolar GTPase AFUA_1G06190 histone H4 arginine methyltransferase RmtA AFUA_2G14020 ABC transporter AFUA_2G09860 purine-cytosine permease AFUA_6G08710 alkaline phosphatase AFUA_8G00720 amino...”
- “...AFUA_1G04720 C-8 sterol isomerase (Erg-1) Disease, virulence and defense (p: 0.072) AFUA_4G00830 MFS peptide transporter AFUA_7G01000 aldehyde dehydrogenase AFUA_3G10770 RTA1 domain protein AFUA_2G16860 MFS multidrug transporter AFUA_1G02730 mitochondrial phosphate carrier protein (Ptp) AFUA_1G06190 histone H4 arginine methyltransferase RmtA Protein Binding (p: 0.0158) AFUA_1G13800 MFS multidrug transporter...”
- “...with each study showing regulation of AfSOD3 (Afu1g14550), hppD , (Afu2g04200), mirB (Afu3g03640) and ald4 (Afu7g01000). In each dataset there was a response to oxidative stress, and significant differential expression of genes involved in transport, fatty acid metabolism and aerobic respiration. There was an increase in...”
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XP_002322147 aminoaldehyde dehydrogenase 2, peroxisomal from Populus trichocarpa
35% identity, 93% coverage
- Proteomic analysis of salt-responsive proteins in the leaves of mangrove Kandelia candel during short-term stress
Wang, PloS one 2014 - “...Cucumis melo AAX35343 HKDHISAYGEGNER(1612.736) 47.63/8.06 40.49/5.97 133/101 1/9 22% Others 23 predicted protein Populus trichocarpa XP_002322147 QLFIDGEWR(1163.5789) QLFIDGEWREPVLK(1729.9249) 54.88/5.25 58.37/5.56 114/108 2/3 5% 33 unknown Glycine max ACU22776 AAYNNPER(934.4539) NSQQFQALR(1091.5814) 41.17/4.8 48.18/5.00 121/99 2/6 21% 41 Unknown Populus trichocarpaPopulus deltoides ABK96657 GNELWYGPDR(1206.589) VDFKEPVWFK(1294.7012) GNELWYGPDRVK(1433.7603) 24.36/4.77 26.13/4.85...”
BCAM0469 putative aldehyde dehydrogenase from Burkholderia cenocepacia J2315
36% identity, 96% coverage
Tery_2599 Aldehyde dehydrogenase (NAD+) from Trichodesmium erythraeum IMS101
38% identity, 95% coverage
Q53FB6 Aldehyde dehydrogenase, mitochondrial (Fragment) from Homo sapiens
39% identity, 90% coverage
4o6rA / B4EJX1 Crystal structure of a putative aldehyde dehydrogenase from burkholderia cenocepacia
36% identity, 96% coverage
- Ligand: adenosine monophosphate (4o6rA)
HD73_3146 aldehyde dehydrogenase family protein from Bacillus thuringiensis serovar kurstaki str. HD73
36% identity, 95% coverage
- Sox transcription in sarcosine utilization is controlled by Sigma(54) and SoxR in Bacillus thuringiensis HD73
Peng, Scientific reports 2016 - “...annotated as amino acid carrier protein ( soxI , HD73_3147), aldehyde dehydrogenase ( soxH , HD73_3146), dihydrodipicolinate synthase ( soxG , HD73_3145), proline racemase ( soxE , HD73_3143), sarcosine oxidase, subunit ( soxB , HD73_3142), Sigma 54 -dependent transcriptional activator ( soxR , HD73_3141), hypothetical protein...”
- Identification of metabolism pathways directly regulated by sigma(54) factor in Bacillus thuringiensis
Peng, Frontiers in microbiology 2015 - “...beta subunit 35.033 HD73_3143 Proline racemase 35.278 HD73_3144 Hypothetical protein 31.999 HD73_3145 Dihydrodipicolinate synthase 34.853 HD73_3146 Aldehyde dehydrogenase 28.844 HD73_3147 Amino acid carrier protein 37.362 HD73_3213 Acetoin:2,6-dichlorophenolindophenol oxidoreductase subunit alpha 25.424 HD73_3214 TPP-dependent acetoin dehydrogenase E1 alpha-subunit 19.979 HD73_3215 Acetoin:2,6-dichlorophenolindophenol oxidoreductase subunit beta 9.610 HD73_3216 Dihydrolipoyllysine-residue...”
G7PIP6 Aldehyde dehydrogenase, mitochondrial from Macaca fascicularis
39% identity, 90% coverage
PAS_chr4_0043 Mitochondrial aldehyde dehydrogenase from Komagataella phaffii GS115
C4R6P6 Mitochondrial aldehyde dehydrogenase from Komagataella phaffii (strain GS115 / ATCC 20864)
F2R0E4 Magnesium-activated aldehyde dehydrogenase, cytosolic from Komagataella phaffii (strain ATCC 76273 / CBS 7435 / CECT 11047 / NRRL Y-11430 / Wegner 21-1)
38% identity, 93% coverage
betB / P54222 betaine aldehyde dehydrogenase (EC 1.2.1.8) from Rhizobium meliloti (strain 1021) (see 2 papers)
SMc00094 BETAINE ALDEHYDE DEHYDROGENASE BADH OXIDOREDUCTASE NAD PROTEIN from Sinorhizobium meliloti 1021
38% identity, 98% coverage
- Comparative genomics and mutagenesis analyses of choline metabolism in the marine Roseobacter clade
Lidbury, Environmental microbiology 2015 - “...following genes used as query sequences were as follows: betA , SMc00093, 637181738; betB , SMc00094, 637181739; betC , SMc00127, 637181740; betT , 637288573; choX , 638910580. Phylogenetic analysis was conducted using the mega 5.2 package (Tamura etal ., 2011 ). The National Centre for Biotechnology...”
Q6C2W9 YALI0F04444p from Yarrowia lipolytica (strain CLIB 122 / E 150)
38% identity, 91% coverage
- Proteomic Study of Response to Copper, Cadmium, and Chrome Ion Stress in Yarrowia lipolytica Strains Isolated from Andean Mine Tailings in Peru
Sánchez-Rojas, Microorganisms 2022 - “...modulated upon chromium treatment, such as glycerol-3-phosphate dehydrogenase (Q6CEQ0), isocitrate dehydrogenase [NAD] (Q6CA33), aldehyde dehydrogenase (Q6C2W9), and HSPs. As already reported, Cr +6 can affect the structure and degradation of proteins, as well as DNA, lipids, and other supramolecular biological compounds due to the oxidizing effect...”
- Fatty aldehyde dehydrogenase multigene family involved in the assimilation of n-alkanes in Yarrowia lipolytica
Iwama, The Journal of biological chemistry 2014 - “...and YALI0E00264p (Q6C7J6), YALI0C03025p (Q6CD79), YALI0F04444p (Q6C2W9), YALI0D07942p (Q6C9V7), Hfd1p (Q6C0L0), Hfd2p (Q6C5T1), Hfd3p (Q6CGN3), and Hfd4p...”
2d4eC / Q5SJP9 Crystal structure of the hpcc from thermus thermophilus hb8
37% identity, 91% coverage
- Ligand: nicotinamide-adenine-dinucleotide (2d4eC)
D0Z05_13800 NAD-dependent succinate-semialdehyde dehydrogenase from Enterobacter hormaechei
36% identity, 97% coverage
pRL120044 succinate-semialdehyde dehydrogenase (NADP+) from Rhizobium leguminosarum bv. viciae 3841
38% identity, 94% coverage
- Pathway of gamma-aminobutyrate metabolism in Rhizobium leguminosarum 3841 and its role in symbiosis
Prell, Journal of bacteriology 2009 - “...shown. c n 2. pRL100252 (gabD4), pRL120628 (gabD5), and pRL120044 (tentatively named gabD6 and similar to SMb20424 but not annotated in S. meliloti 1021). gabD2...”
- The genome of Rhizobium leguminosarum has recognizable core and accessory components
Young, Genome biology 2006 - “...on acetate. There are six genes whose products closely resemble succinate semialdehyde dehydrogenases (pRL100134, pRL100252, pRL120044, pRL120603, pRL120628, and RL0101), which could feed succinate semialdehyde directly into the TCA cycle. Two of these (pRL100134 and pRL100252) are on the symbiosis plasmid, and RL0101 is the characterized...”
AL1A1_RABIT / Q8MI17 Aldehyde dehydrogenase 1A1; 3-deoxyglucosone dehydrogenase; ALDH-E1; ALHDII; Aldehyde dehydrogenase family 1 member A1; Aldehyde dehydrogenase, cytosolic; Retinal dehydrogenase 1; RALDH 1; RalDH1; EC 1.2.1.19; EC 1.2.1.28; EC 1.2.1.3; EC 1.2.1.36 from Oryctolagus cuniculus (Rabbit) (see paper)
39% identity, 94% coverage
- function: Cytosolic dehydrogenase that catalyzes the irreversible oxidation of a wide range of aldehydes to their corresponding carboxylic acid (PubMed:12941160). Functions downstream of retinol dehydrogenases and catalyzes the oxidation of retinaldehyde into retinoic acid, the second step in the oxidation of retinol/vitamin A into retinoic acid. This pathway is crucial to control the levels of retinol and retinoic acid, two important molecules which excess can be teratogenic and cytotoxic (By similarity). Also oxidizes aldehydes resulting from lipid peroxidation like (E)-4-hydroxynon-2-enal/HNE, malonaldehyde and hexanal that form protein adducts and are highly cytotoxic. By participating for instance to the clearance of (E)-4- hydroxynon-2-enal/HNE in the lens epithelium prevents the formation of HNE-protein adducts and lens opacification (PubMed:12941160). Functions also downstream of fructosamine-3-kinase in the fructosamine degradation pathway by catalyzing the oxidation of 3-deoxyglucosone, the carbohydrate product of fructosamine 3-phosphate decomposition, which is itself a potent glycating agent that may react with lysine and arginine side-chains of proteins (By similarity). Has also an aminobutyraldehyde dehydrogenase activity and is probably part of an alternative pathway for the biosynthesis of GABA/4-aminobutanoate in midbrain, thereby playing a role in GABAergic synaptic transmission (By similarity).
catalytic activity: an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH (RHEA:16185)
catalytic activity: all-trans-retinal + H2O + NAD(+) = all-trans-retinoate + 2 H(+) + NADH (RHEA:42080)
catalytic activity: 9-cis-retinal + H2O + NAD(+) = 9-cis-retinoate + 2 H(+) + NADH (RHEA:42084)
catalytic activity: 11-cis-retinal + H2O + NAD(+) = 11-cis-retinoate + 2 H(+) + NADH (RHEA:47132)
catalytic activity: 13-cis-retinal + H2O + NAD(+) = 13-cis-retinoate + 2 H(+) + NADH (RHEA:67332)
catalytic activity: (E)-4-hydroxynon-2-enal + H2O + NAD(+) = (E)-4-hydroxynon-2- enoate + 2 H(+) + NADH (RHEA:67248)
catalytic activity: H2O + malonaldehyde + NAD(+) = 3-oxopropanoate + 2 H(+) + NADH (RHEA:67252)
catalytic activity: H2O + hexanal + NAD(+) = 2 H(+) + hexanoate + NADH (RHEA:67276)
catalytic activity: H2O + NAD(+) + propanal = 2 H(+) + NADH + propanoate (RHEA:67256)
catalytic activity: 3-deoxyglucosone + H2O + NAD(+) = 2-dehydro-3-deoxy-D- gluconate + 2 H(+) + NADH (RHEA:67244)
catalytic activity: acetaldehyde + H2O + NAD(+) = acetate + 2 H(+) + NADH (RHEA:25294)
catalytic activity: benzaldehyde + H2O + NAD(+) = benzoate + 2 H(+) + NADH (RHEA:11840)
catalytic activity: 4-aminobutanal + H2O + NAD(+) = 4-aminobutanoate + 2 H(+) + NADH (RHEA:19105)
subunit: Homotetramer (By similarity). Interacts with PRMT3; the interaction is direct, inhibits ALDH1A1 aldehyde dehydrogenase activity and is independent of the methyltransferase activity of PRMT3 (By similarity).
blr3954 methylmalonate-semialdehyde dehydrogenase from Bradyrhizobium japonicum USDA 110
Q89N88 methylmalonate-semialdehyde dehydrogenase (CoA acylating) from Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110)
37% identity, 94% coverage
- Pleiotropic Effects of PhaR Regulator in Bradyrhizobium diazoefficiens Microaerobic Metabolism
Quelas, International journal of molecular sciences 2024 - “...in the phaR mutant ( Table S3 ). These genes code for a methylmalonate-semialdehyde dehydrogenase (Blr3954), an acyl-CoA dehydrogenase (Blr3955), an enoyl-CoA hydratase (Blr3956), a 3-hydroxyisobutyrate dehydrogenase (Blr3957), and an acyl-coenzyme A synthetase (Blr3958). In turn, the encoded polypeptides were more abundant in the phaR mutant,...”
- “...AGCGCGGCGTCG GGCGTCGCAGGC blr3456blr3459 bll3830 - Q89NK8 hypothetical protein 2.3 1.0 114 30 AGCTATGCGTCG AGCGTTGCAGTT - blr3954 - Q89N88 methylmalonate-semialdehyde dehydrogenase 3.7 4.4 165 CGCCCCGCACGA blr3954blr3957 blr3958 - Q89N84 putative acetyl-coenzyme A synthetase (EC 6.2.1.1) 2.6 2.4 255 199 194 GGCGCGGCGACG GGCGGGGCAGGG GGCAGGGCGGGG - bll4252 - Q89ME1...”
- Proteomic Characterization of Bradyrhizobium diazoefficiens Bacteroids Reveals a Post-Symbiotic, Hemibiotrophic-Like Lifestyle of the Bacteria within Senescing Soybean Nodules
Strodtman, International journal of molecular sciences 2018 - “...cofactor balancing [ 28 , 29 , 30 , 31 , 32 ], methymalonate-semialdehyde dehydrogenase (blr3954), which participates in active turnover in branched chain amino acids and propanoate metabolism, leading to a source of acetyl-CoA, and propanoyl-CoA, a putative alcohol dehydrogenase precursor (bll6220) and carbonic anhydrase...”
- “...NP_767576 Periplasm ATP-dependent protease, ATP-binding subunit blr1404 NP_768044 Periplasm Dehydrogenase blr2146 NP_768786 Periplasm Methylmalonate-semialdehyde dehydrogenase blr3954 NP_770594 Periplasm Probable transaldolase blr6758 NP_773398 Periplasm Histone H4 - Glyma02g38920 Periplasm Histone H3 - Glyma06g32880 Periplasm Glu/leu/phe/val dehydrogenase - Glyma16g04560 Periplasm...”
- Pleiotropic Effects of PhaR Regulator in Bradyrhizobium diazoefficiens Microaerobic Metabolism
Quelas, International journal of molecular sciences 2024 - “...blr3456blr3459 bll3830 - Q89NK8 hypothetical protein 2.3 1.0 114 30 AGCTATGCGTCG AGCGTTGCAGTT - blr3954 - Q89N88 methylmalonate-semialdehyde dehydrogenase 3.7 4.4 165 CGCCCCGCACGA blr3954blr3957 blr3958 - Q89N84 putative acetyl-coenzyme A synthetase (EC 6.2.1.1) 2.6 2.4 255 199 194 GGCGCGGCGACG GGCGGGGCAGGG GGCAGGGCGGGG - bll4252 - Q89ME1 putative hydrolase...”
UW3_RS0108160 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase from Pseudomonas donghuensis
38% identity, 97% coverage
ALDH1L2 / Q3SY69 10-formyltetrahydrofolate dehydrogenase 2 (EC 3.5.1.10; EC 1.5.1.6) from Homo sapiens (see 4 papers)
AL1L2_HUMAN / Q3SY69 Mitochondrial 10-formyltetrahydrofolate dehydrogenase; Mitochondrial 10-FTHFDH; mtFDH; Aldehyde dehydrogenase family 1 member L2; EC 1.5.1.6 from Homo sapiens (Human) (see 3 papers)
Q3SY69 formyltetrahydrofolate dehydrogenase (EC 1.5.1.6) from Homo sapiens (see paper)
37% identity, 51% coverage
- function: Mitochondrial 10-formyltetrahydrofolate dehydrogenase that catalyzes the NADP(+)-dependent conversion of 10-formyltetrahydrofolate to tetrahydrofolate and carbon dioxide.
catalytic activity: (6R)-10-formyltetrahydrofolate + H2O + NADP(+) = (6S)-5,6,7,8- tetrahydrofolate + CO2 + H(+) + NADPH (RHEA:10180) - Proteomic and Metabolomic Analysis of Bone Marrow and Plasma from Patients with Extramedullary Multiple Myeloma Identifies Distinct Protein and Metabolite Signatures
Dunphy, Cancers 2023 - “...catalytic subunit SEC11C SEC11C 5.19 0.0016 Q13813 Spectrin alpha chain, non-erythrocytic 1 SPTAN1 2.10 0.0023 Q3SY69 Mitochondrial 10-formyltetrahydrofolate dehydrogenase ALDH1L2 7.33 0.0033 P08240 Signal recognition particle receptor subunit alpha SRPR 2.48 0.0035 P30044 Peroxiredoxin-5, mitochondrial PRDX5 1.77 0.0037 Q7KZF4 Staphylococcal nuclease domain-containing protein 1 SND1 2.91...”
- Dichlorvos-induced formation of isopeptide crosslinks between proteins in SH-SY5Y cells
Schopfer, Analytical biochemistry 2022 - “...+ 2.8 65.4 AVNKVKDTPGLGK 450 VK Hemicentin-1 Q96RW7 KGVDIE 4391 ISHR 18 Mitochondrial 10-formyltetrahydrofolate dehydrogenase Q3SY69 538.5169 29.11 5 29.0 + 7.4 57.2 VKGKTIK 89 EVAEAYR Lysine-specific demethylase 5C P41229 VALEVE 784 DGRK 19 DnaJ homolog subfamily C member 9 Q8WXX5 538.5166 29.63 5 43.5 +...”
- Electron-Transfer/Higher-Energy Collision Dissociation (EThcD)-Enabled Intact Glycopeptide/Glycoproteome Characterization
Yu, Journal of the American Society for Mass Spectrometry 2017 - “...Zinc finger MYM-type protein 1 U * N1006 Q86XJ1 GAS2-like protein 3 U * N401 Q3SY69 Mitochondrial 10-formyltetrahydrofolate dehydrogenase U * N142 Q8WXG9 G-protein coupled receptor 98 N3794 N3794 Q92833 Protein Jumonji U * N1201 Q96N64 PWWP domain-containing protein 2A U * N563 Q99459 Cell division...”
- The Fatty Acid β-Oxidation Pathway is Activated by Leucine Deprivation in HepG2 Cells: A Comparative Proteomics Study
Yan, Scientific reports 2017 - “...3.423 P21695 Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic GPD1 3.393*|- 3.393 P47989 Xanthine dehydrogenase/oxidase XDH 3.342*|- 3.342 Q3SY69 Mitochondrial 10-formyltetrahydrofolate dehydrogenase ALDH1L2 3.299*|- 3.299 Q16696 Cytochrome P450 2A13 CYP2A13 2.950*|- 2.950 P26440 Isovaleryl-CoA dehydrogenase, mitochondrial IVD 2.722*|- 2.722 Q3LXA3 Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing) DAK 2.606*|- 2.606...”
- Exploring the Human-Nipah Virus Protein-Protein Interactome.
Martinez-Gil, Journal of virology 2017 - Aldehyde dehydrogenase is used by cancer cells for energy metabolism
Kang, Experimental & molecular medicine 2016 - “...y10(2+) ALDH1L1 Target O75891 H. sapiens (human) 24.7 714.8483 VLEVEDSTDFFK 34.6 y3,y7,y8,y9,y10 y7 ALDH1L2 Target Q3SY69 H. sapiens 30.1 786.8863 ANSTEYGLASGVFTR 37.2 y5,y6,y7,y9,y10 y9 ALDH2 Target P05091 H. sapiens (human) 32.7 764.3938 ANNSTYGLAAAVFTK 36.4 y3,y6,y7,y9,y10 y9 ALDH2 Target P05091 H. sapiens (human) 38.7 766.3751 TIPIDGDFFSYTR 36.4...”
- A framework for application of metabolic modeling in yeast to predict the effects of nsSNV in human orthologs.
Dingerdissen, Biology direct 2014 - “...5-hydroxy-L-lysine SID: 4433 Q16873 r k 104 Leukotriene A4 CID: 5280383 Leukotriene C4 CID: 5280493 Q3SY69 y x 127 10-formyltetrahydrofolate CID: 122347 Tetrahydrofolate CID: 91443 Q6PI48 r x 266 L-aspartic acid CID: 5960 L-aspartyl-tRNA(Asp) SID: 5893 Q8IVS2 s t 153 Malonyl-CoA CID: 10663 Malonyl-[acyl-carrier-protein] SID: 4431...”
- Post-translational modifications of mitochondrial aldehyde dehydrogenase and biomedical implications.
Song, Journal of proteomics 2011 - “...AGRLFVED 699 O75891 ALDH1L2 700 GAV F FNK G EN C I A AGRLFVEE 720 Q3SY69 ALDH2 291 FAL F FNQ G QC C C A GSRTFVQE 311 P05091 ALDH3A1 216 WGK F MNS G QT C V A PDYILCDP 236 P30838 ALDH3A2 213 WGK Y...”
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HP15_3144 Aldehyde dehydrogenase (EC 1.2.1.3) from Marinobacter adhaerens HP15
37% identity, 90% coverage
- mutant phenotype: Specifically important for utilizing Ethanol. Automated validation from mutant phenotype: the predicted function (RXN66-3) was linked to the condition via a MetaCyc pathway. This annotation was also checked manually.
Q5RFM9 Cytosolic 10-formyltetrahydrofolate dehydrogenase from Pongo abelii
39% identity, 52% coverage
BC2832 Aldehyde dehydrogenase from Bacillus cereus ATCC 14579
Q81CE0 Aldehyde dehydrogenase from Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711)
36% identity, 95% coverage
- Linking genome content to biofuel production yields: a meta-analysis of major catabolic pathways among select H2 and ethanol-producing bacteria
Carere, BMC microbiology 2012 - “...Geoth_0268 Geoth_1572 Geoth_3879 Geoth_0879 Geoth_0652 Geoth_1941 Geoth_2349 Geoth_3494 Geoth_0631 B. cereus ATCC 14579 BC5387 BC4637 BC2832 BC0802 BC4365 BC3555 BC2529 BC1285 BC2220 Abbreviations: pta , phosphotransacetylase; ack , acetate kinase; atk , acetate thiokinase; aldH , acetaldehyde dehydrogenase; adh , alcohol dehydrogenase; adhE ; bifunctional acetylaldehyde/alcohol...”
- Prediction and characterization of enzymatic activities guided by sequence similarity and genome neighborhood networks
Zhao, eLife 2014 - “...Q73CS0, Q7CFV0, Q7CTP1, Q7CTP2, Q7CTP3, Q7CTP4, Q7CTQ2, Q7CTQ3, Q7CTQ5, Q7CVK1, Q7NU77, Q81CD6, Q81CD7, Q81CD8, Q81CD9, Q81CE0, Q81HB0, Q81HB1, Q8FYS0, Q8P833, Q8YFD6, Q92WR9, Q92WS1, Q9I476, Q9I489, and Q9I492. Funding Information This paper was supported by the following grants: National Institute of General Medical Sciences FundRef identification ID:...”
Q5K8N2 Aldehyde dehydrogenase (ALDDH), putative from Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)
36% identity, 90% coverage
AL1A1_SHEEP / P51977 Aldehyde dehydrogenase 1A1; 3-deoxyglucosone dehydrogenase; ALDH-E1; ALHDII; Aldehyde dehydrogenase family 1 member A1; Aldehyde dehydrogenase, cytosolic; Retinal dehydrogenase 1; RALDH 1; RalDH1; EC 1.2.1.19; EC 1.2.1.28; EC 1.2.1.3; EC 1.2.1.36 from Ovis aries (Sheep) (see 2 papers)
39% identity, 94% coverage
- function: Cytosolic dehydrogenase that catalyzes the irreversible oxidation of a wide range of aldehydes to their corresponding carboxylic acid (PubMed:26373694). Functions downstream of retinol dehydrogenases and catalyzes the oxidation of retinaldehyde into retinoic acid, the second step in the oxidation of retinol/vitamin A into retinoic acid. This pathway is crucial to control the levels of retinol and retinoic acid, two important molecules which excess can be teratogenic and cytotoxic (By similarity). Also oxidizes aldehydes resulting from lipid peroxidation like (E)-4-hydroxynon-2-enal/HNE, malonaldehyde and hexanal that form protein adducts and are highly cytotoxic. By participating for instance to the clearance of (E)-4- hydroxynon-2-enal/HNE in the lens epithelium prevents the formation of HNE-protein adducts and lens opacification. Functions also downstream of fructosamine-3-kinase in the fructosamine degradation pathway by catalyzing the oxidation of 3-deoxyglucosone, the carbohydrate product of fructosamine 3-phosphate decomposition, which is itself a potent glycating agent that may react with lysine and arginine side-chains of proteins (By similarity). Has also an aminobutyraldehyde dehydrogenase activity and is probably part of an alternative pathway for the biosynthesis of GABA/4-aminobutanoate in midbrain, thereby playing a role in GABAergic synaptic transmission (By similarity).
catalytic activity: an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH (RHEA:16185)
catalytic activity: all-trans-retinal + H2O + NAD(+) = all-trans-retinoate + 2 H(+) + NADH (RHEA:42080)
catalytic activity: 9-cis-retinal + H2O + NAD(+) = 9-cis-retinoate + 2 H(+) + NADH (RHEA:42084)
catalytic activity: 11-cis-retinal + H2O + NAD(+) = 11-cis-retinoate + 2 H(+) + NADH (RHEA:47132)
catalytic activity: 13-cis-retinal + H2O + NAD(+) = 13-cis-retinoate + 2 H(+) + NADH (RHEA:67332)
catalytic activity: 3-deoxyglucosone + H2O + NAD(+) = 2-dehydro-3-deoxy-D- gluconate + 2 H(+) + NADH (RHEA:67244)
catalytic activity: (E)-4-hydroxynon-2-enal + H2O + NAD(+) = (E)-4-hydroxynon-2- enoate + 2 H(+) + NADH (RHEA:67248)
catalytic activity: H2O + malonaldehyde + NAD(+) = 3-oxopropanoate + 2 H(+) + NADH (RHEA:67252)
catalytic activity: H2O + hexanal + NAD(+) = 2 H(+) + hexanoate + NADH (RHEA:67276)
catalytic activity: H2O + NAD(+) + propanal = 2 H(+) + NADH + propanoate (RHEA:67256)
catalytic activity: acetaldehyde + H2O + NAD(+) = acetate + 2 H(+) + NADH (RHEA:25294)
catalytic activity: benzaldehyde + H2O + NAD(+) = benzoate + 2 H(+) + NADH (RHEA:11840)
catalytic activity: 4-aminobutanal + H2O + NAD(+) = 4-aminobutanoate + 2 H(+) + NADH (RHEA:19105)
subunit: Homotetramer (PubMed:26373694, PubMed:9862807). Interacts with PRMT3; the interaction is direct, inhibits ALDH1A1 aldehyde dehydrogenase activity and is independent of the methyltransferase activity of PRMT3 (By similarity). - Genetic and functional analysis of the styrene catabolic cluster of Pseudomonas sp. strain Y2
Velasco, Journal of bacteriology 1998 - “...L49438 U39411 Z92524 Z92524 U24215 S43184 X97453 X99402 P51977 D83955 D63341 P10384 U24215 a Sequences included in this analysis: Pcl, phenylacetyl-coenzyme A...”
NCU03415 aldehyde dehydrogenase from Neurospora crassa OR74A
37% identity, 95% coverage
- L-Carnitine Production Through Biosensor-Guided Construction of the Neurospora crassa Biosynthesis Pathway in Escherichia coli
Kugler, Frontiers in bioengineering and biotechnology 2021 - “...N. crassa . TMABADH.1S and TMABADH.1 were derived from NCU00378, and TMABADH.2 was derived from NCU03415. pECXT99A was used as the empty vector control (EV). Means of three replicates are shown. Error bars were calculated by error analysis from the standard deviations of the enzyme assays...”
- Identification and manipulation of Neurospora crassa genes involved in sensitivity to furfural
Feldman, Biotechnology for biofuels 2019 - “...or downregulated when exposed to furfural. Five putative aldehyde dehydrogenase genes met these criteria: NCU03076, NCU03415, NCU09648, NCU00936 and NCU00378. The phenotypic consequences of exposing strains carrying a deletion of each of these predicted aldehyde dehydrogenase genes to 60mM furfural were assessed: one mutant, NCU00378, previously...”
- “...crassa [ 48 ]. Strains carrying deletions of the other identified aldehyde dehydrogenase genes (NCU03076, NCU03415, NCU09648 or NCU00936) did not show a growth phenotype that differed from the wild-type strain when exposed to furfural. The AHD-2 protein is the closest homolog of the mitochondrial aldehyde...”
- Cold Shock as a Screen for Genes Involved in Cold Acclimatization in Neurospora crassa
Watters, G3 (Bethesda, Md.) 2018 - “...Factors NCU04899 17402 dense tricarboxylic acid-15 tca-15 E. coli CS Orth Catalytic Activity Metabolic Process NCU03415 12921 fail aldehyde dehydrogenase CBS-3 E. coli CS Orth NCU11289 23565 fail aldo-keto reductase E. coli CS Orth Catalytic Activity/transporter Activity NCU00097 11110 fail BEAK-1 bek-1 Transc Factors NCU02017 11108...”
- Characterization of indole-3-pyruvic acid pathway-mediated biosynthesis of auxin in Neurospora crassa
Sardar, PloS one 2018 - “...used for bioinformatics as well as for experimental studies were aro-8 (NCU09116), cfp (NCU02193), cbs-3 (NCU03415), ahd-3 (NCU09648), ahd-2 (NCU00378) and mox-2 (NCU03755). Site-specific binding of enzymes to their respective cofactors is essential to determine their active states. The ligand binding sites for the group of...”
- Modulation of Circadian Gene Expression and Metabolic Compensation by the RCO-1 Corepressor of Neurospora crassa
Olivares-Yañez, Genetics 2016 - “...NCU00629 NCU01227 NCU01528 NCU02139 NCU02713 NCU03317 NCU03415 NCU04851 NCU04866 NCU05855 NCU07027 NCU07442 NCU09873 NCU10007 NCU11201 NCU06660 NCU07649...”
- BEM46 shows eisosomal localization and association with tryptophan-derived auxin pathway in Neurospora crassa
Kollath-Leiß, Eukaryotic cell 2014 - “...in N. crassa: NCU09166.7 (tam1), NCU02397.7 (ipd), and NCU03415 (iad1) (see Fig. S3 in the supplemental material). Regulation of transcription of the auxin...”
- The functions of grainy head-like proteins in animals and fungi and the evolution of apical extracellular barriers
Paré, PloS one 2012 - “...important in fungal pea-pathogens for detoxifying host defensive chemicals [58] ; the aldehyde dehydrogenase gene (NCU03415), which encodes a broadly acting detoxification and metabolic enzyme; the genes catalase-3 (NCU00355) (another verified component of the cell wall [46] ) and NAD(P) transhydrogenase (NCU01140), which encode enzymes known...”
- “...following genes: NCU04883 chitinase 1 ; NCU04850 exo-beta-1,3-glucanase ; NCU07787 cerato-platanin ; NCU10051 flavohemoglobin ; NCU03415 aldehyde dehydrogenase ; NCU07821 dimethylaniline monooxygenase ; NCU04533 abundant perithecial protein ; NCU07610 taurine dioxygenase ; NCU07819 alpha-ketoglutarate-dependent taurine dioxygenase ; and NCU07232 heat shock protein 30 . Primer sequences...”
- Differential impact of nutrition on developmental and metabolic gene expression during fruiting body development in Neurospora crassa
Wang, Fungal genetics and biology : FG & B 2012 - “...exoglucanase I precursor (NCU07340), two 60S ribosomal proteins (NCU05804, 00706) and an aldehyde dehydrogenase (NAD+, NCU03415) were significantly down-regulated during late development in SCM samples ( Table S5 ). 3.3. Transcriptional profiling of N. crassa on SCM Growing on SCM, expression patterns for well measured genes...”
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SAB2006c aldehyde dehydrogenase from Staphylococcus aureus RF122
38% identity, 97% coverage
- Alternative Sigma Factor B in Bovine Mastitis-Causing Staphylococcus aureus: Characterization of Its Role in Biofilm Formation, Resistance to Hydrogen Peroxide Stress, Regulon Members
Supa-Amornkul, Frontiers in microbiology 2019 - “...RNA sequencing results; i.e., B is a positive regulator for asp23, sarA, katA, yabJ, sodA, SAB2006c , and nrdD expressions. In the RF122 strain, B plays a role in biofilm formation, general stress response (e.g., H 2 O 2 ), and regulation of virulence factors and...”
- “...[ asp23, sarA , catalase gene ( katA ), yabJ , aldehyde dehydrogenase gene ( SAB2006c ), sodA , and nrdD ] to verify B -dependence identified by RNA-Seq using LightCycler 480 (Roche). Expression levels were normalized with those of the housekeeping gene rpoB . For...”
YLX7_SCHPO / Q9URW9 Putative aldehyde dehydrogenase-like protein C922.07c; EC 1.2.1.- from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
SPAC922.07c aldehyde dehydrogenase (predicted) from Schizosaccharomyces pombe
36% identity, 95% coverage
- Comparative transcriptome analysis reveals candidate genes related to cadmium accumulation and tolerance in two almond mushroom (Agaricus brasiliensis) strains with contrasting cadmium tolerance
Liu, PloS one 2020 - “...-1.94 -2.00 c32902.graph_c0 Aldose 1-epimerase gal10 3.37 5.56 7.55 c19606.graph_c0 Putative aldehyde dehydrogenase-like protein C922.07c SPAC922.07c 3.15 2.77 3.48 c19606.graph_c1 Aldehyde dehydrogenase aldA 3.92 c19606.graph_c2 Aldehyde dehydrogenase aldA 1.85 3.29 2.58 2.55 3.67 c19606.graph_c3 Aldehyde dehydrogenase aldA 2.99 2.32 2.56 3.67 c32143.graph_c1 Aldehyde dehydrogenase family -1.20...”
- “...-1.27 -1.04 c32789.graph_c1 Acetyl-CoA acetyltransferase PAT1 1.83 1.28 1.34 c19606.graph_c0 Putative aldehyde dehydrogenase-like protein C922.07c SPAC922.07c 3.15 2.77 3.48 c19606.graph_c1 Aldehyde dehydrogenase aldA 3.92 c19606.graph_c2 Aldehyde dehydrogenase aldA 1.85 3.29 2.58 2.55 3.67 c19606.graph_c3 Aldehyde dehydrogenase aldA 2.99 2.32 2.56 3.67 c29558.graph_c0 Aldehyde dehydrogenase aldA 2.33...”
- Genetic controls of DNA damage avoidance in response to acetaldehyde in fission yeast
Noguchi, Cell cycle (Georgetown, Tex.) 2017 - “...to ALDH2 (query coverage, 91%). The other protein, SPAC922.07c, which consists of 469 amino acids, showed 48% identity and 67% similarity to ALDH2 (query...”
- “...ALDH2, the 3 most similar proteins, SPAC9E9.09c, SPAC922.07c, and SPCC550.10 were designated atd1, atd2, and atd3 (putative AceTaldehyde Dehydrogenase),...”
GNP06_05115 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase from Pseudomonas sp. TDA1
38% identity, 97% coverage
- Extracellular degradation of a polyurethane oligomer involving outer membrane vesicles and further insights on the degradation of 2,4-diaminotoluene in Pseudomonas capeferrum TDA1
Puiggené, Scientific reports 2022 - “...0.1117 1.970.35 4.12E-08 Ring-cleaving dioxygenase GNP06_05110 6 hpaE*** 2.821.52 0.1927 3.310.56 1.32E-08 5-carboxymethyl-2-hydroxymuconic semialdehyde dehydrogenase GNP06_05115 7 GNP06_05035 6.022.85 0.1295 7.231.20 8.51E-09 Aminomuconate deaminase GNP06_05035 8+9 hpcE_1*** 2.761.73 0.2721 3.300.59 7.69E-08 Homoprotocatechuate catabolism bifunctional isomerase/decarboxylase GNP06_05120 */**/***Adjacent genes (to each other). a log2 Fold Changestandard error...”
- “...the presence of 2,4-TDA ( data not shown ). Encoded by the adjacent gene hpaE (GNP06_05115), 5-carboxymethyl-2-hydroxymuconic semialdehyde dehydrogenase could yield 4-amino-2-hydroxy-muconate. Finally, the uncharacterized gene GNP06_05035 , which encodes a putative aminomuconate deaminase, could enable the second deamination step. This gene holds many homologues in...”
- Toward Biorecycling: Isolation of a Soil Bacterium That Grows on a Polyurethane Oligomer and Monomer
Espinosa, Frontiers in microbiology 2020 - “...6 , 8 and 9 : Enzymes for the homoprotocatechuate meta -cleavage pathway (candidate genes GNP06_05115, GNP06_05105 and GNP06_05120/25). 7 : 4-amino-2-hydroxymuconate deaminase (candidate genes GNP06_14860 or GNP06_05035). Studies showed that aromatic compounds with electron-donating substituents, such as amino groups, are preferably degraded via the meta...”
BLJAPNOD_03725 betaine-aldehyde dehydrogenase from Ensifer sp. M14
38% identity, 97% coverage
Q0H2G3 retinal dehydrogenase (EC 1.2.1.36) from Danio rerio (see paper)
NP_001038210 aldehyde dehydrogenase family 1 member A3 from Danio rerio
38% identity, 93% coverage
AL1A7_MOUSE / O35945 Aldehyde dehydrogenase, cytosolic 1; ALDH class 1; ALDH-E1; ALHDII; Aldehyde dehydrogenase family 1 member A7; Aldehyde dehydrogenase phenobarbital-inducible; EC 1.2.1.3 from Mus musculus (Mouse) (see paper)
O35945 aldehyde dehydrogenase (NAD+) (EC 1.2.1.3) from Mus musculus (see paper)
B2RTL5 Aldehyde dehydrogenase family 1, subfamily A7 from Mus musculus
38% identity, 93% coverage
- function: Can oxidize benzaldehyde, propionaldehyde and acetaldehyde (By similarity). No detectable activity with retinal.
catalytic activity: an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH (RHEA:16185)
subunit: Homotetramer. - Redox Proteomic Profile of Tirapazamine-Resistant Murine Hepatoma Cells
Nemeikaitė-Čėnienė, International journal of molecular sciences 2023 - “...chain 4.80 1.16 4 Aldh3b1 Q3TX25 Aldehyde dehydrogenase family 3 member B1 3.43 5 Aldh1a7 B2RTL5 Aldehyde dehydrogenase family 1 3.42 5.16 6 Gsto1 O09131 Glutathione S-transferase omega-1 2.63 0.90 7 Cbr3 Q8K354 Carbonyl reductase (NADPH) 3 2.62 1.54 8 Adh1 P00329 Alcohol dehydrogenase 1 2.43...”
- Decreased Klotho Expression Causes Accelerated Decline of Male Fecundity through Oxidative Injury in Murine Testis.
Wang, Antioxidants (Basel, Switzerland) 2023 - “...Catalase 1.258 Q3UF58; Q91XI2; Q8C6E3; Q542K4; Q3UZE7; Q3TVZ1; P24270 Aldh1a7 Aldehyde dehydrogenase, cytosolic 1 1.254 B2RTL5; O35945 Ttr Transthyretin 1.140 Q5M9K1; P07309; Q9D6A4 Aldh1a1 Retinal dehydrogenase 1 1.110 P24549 Aldh1b1 Aldehyde dehydrogenase X, mitochondrial 0.844 Q9CZS1 Tpi1 Triosephosphate isomerase 0.679 P17751; P17751-2; H7BXC3 Aldh2 Aldehyde dehydrogenase,...”
- The impact of abstinence from chronic alcohol consumption on the mouse striatal proteome: sex and subregion-specific differences
Duffus, Frontiers in pharmacology 2024 - “...intermediate peptidase 0.0089 A0A8Q0Q6H9 Steroid receptor RNA activator 1 0.0476 Q8BGT5 Alanine aminotransferase 2 0.0348 O35945 Aldehyde dehydrogenase, cytosolic 1 0.0139 V9GXP8 ELKS/Rab6-interacting/CAST family member 1 0.0443 P63300 Selenoprotein W OS = Mus musculus 0.0248 E9Q7M2 TSC22 domain family, member 2 0.0368 E9Q448 Tropomyosin alpha -1...”
- Proteins from toad's parotoid macroglands: do they play a role in gland functioning and chemical defence?
Kowalski, Frontiers in zoology 2023 - “...10 Q3T0X5 112 29,797 3 6 Proteasome subunit alpha type-1 Proteolysis, immune response 7, 10 O35945 111 54,921 1 2 Aldehyde dehydrogenase, cytosolic 1 Ethanol metabolism 7 P00168 111 10,026 6 49 Cytochrome b5 (Fragment) Electron transport 8 Q76KP1 108 116,855 7 1 N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1...”
- Comparative proteomic analysis of exosomes derived from endothelial cells and Schwann cells.
Wang, PloS one 2023 - “...p65 P14602 HSPB1 Heat shock protein beta-1 Q9WVJ9 EFEMP2 EGF-containing fibulin-like extracellular matrix protein 1 O35945 ALDH1A7 Aldehyde dehydrogenase, cytosolic 1 P37889 FBLN2 Fibulin-2 P18242 CATHEPSIN Cathepsin Exosome proteins associated with vascular function. The table shows a list of proteins that are enriched in EC-Exo and...”
- “...II subunit delta Q80X90 FLNB Filamin-B SC-Exo enriched proteins Protein ID Gene name Protein name O35945 ALDH1a7 Aldehyde dehydrogenase, cytosolic 1 O08917 FLOT1 Flotillin-1 P18872 GNAO1 Guanine nucleotide-binding protein G(o) subunit alpha Q62059 VCAN Versican core protein O08989 MRAS Ras-related protein M-Ras Q07235 SERPINE2 Plasminogen activator...”
- Decreased Klotho Expression Causes Accelerated Decline of Male Fecundity through Oxidative Injury in Murine Testis.
Wang, Antioxidants (Basel, Switzerland) 2023 - “...1.258 Q3UF58; Q91XI2; Q8C6E3; Q542K4; Q3UZE7; Q3TVZ1; P24270 Aldh1a7 Aldehyde dehydrogenase, cytosolic 1 1.254 B2RTL5; O35945 Ttr Transthyretin 1.140 Q5M9K1; P07309; Q9D6A4 Aldh1a1 Retinal dehydrogenase 1 1.110 P24549 Aldh1b1 Aldehyde dehydrogenase X, mitochondrial 0.844 Q9CZS1 Tpi1 Triosephosphate isomerase 0.679 P17751; P17751-2; H7BXC3 Aldh2 Aldehyde dehydrogenase, mitochondrial...”
- LRP1 loss in airway epithelium exacerbates smoke-induced oxidative damage and airway remodeling.
Garcia-Arcos, Journal of lipid research 2022 - “...5 (class III), chi polypeptide Q6P5I3 1.825 2.97E-02 Aldh1a7 aldehyde dehydrogenase family 1, subfamily A7 O35945 2.197 2.14E-03 CAT catalase Q3UF58 0.8 3.10E-01 CES1 carboxylesterase 1 Q8VCT4 1.226 1.27E-03 GLO1 glyoxalase I Q9CPU0 0.881 9.14E-03 GPX1 glutathione peroxidase 1 A0A0A6YY34 0.921 9.29E-01 GSR glutathione-disulfide reductase Q3UAS7...”
- Diabetes Induced Alterations in Murine Vitreous Proteome Are Mitigated by IL-6 Trans-Signaling Inhibition.
Robinson, Investigative ophthalmology & visual science 2020 - “...17.52 0.0027 15.24 0.0443 Q78ZA7 Nap1l4 Nucleosome assembly protein 1like 4 17.43 0.0027 13.73 0.0767 O35945 Aldh1a7 Aldehyde dehydrogenase, cytosolic 1 16.92 0.0050 1.00 1.0000 P01027 C3 Complement C3 16.38 0.0082 1.00 1.0000 P48774 Gstm5 Glutathione S-transferase Mu 5 16.33 0.0049 3.68 1.0000 Q61838 A2m Alpha-2-macroglobulin...”
- “...Change Fold Change Accession Symbol Description Diabetic * P Value Diab + Sgp130Fc P Value O35945 Aldh1a7 Aldehyde dehydrogenase, cytosolic 1 6.71 0.0116 3.24 0.8255 P22599 Serpina1b Alpha-1-antitrypsin 1-2 10.78 0.0461 1.18 0.3521 Q00623 Apoa1 Apolipoprotein A-1 515.5 0.0140 33.15 0.9006 P01027 C3 Complement C3 209.3...”
- MS/MS in silico subtraction-based proteomic profiling as an approach to facilitate disease gene discovery: application to lens development and cataract.
Aryal, Human genetics 2020 - “...Dong and Chung 1991 ) 27 Nol3 Q9D1X0 Nucleolar protein 3 None found 28 Aldh1a7 O35945 Aldehyde dehydrogenase, cytosolic 1 None found 29 Snx18 Q91ZR2 Sorting nexin-18 None found 30 Prox1 P48437 Prospero homeobox protein 1 lens fiber elongation * ( Wigle et al. 1999 )...”
- Mass spectrometry-based analysis of murine bronchoalveolar lavage fluid following respiratory exposure to 4,4'-methylene diphenyl diisocyanate aerosol
Hettick, Xenobiotica; the fate of foreign compounds in biological systems 2018 - “...576 2.04 Down A0A0J9YUJ8 Gelsolin 18 727 2.10 Down Q9Z1R9 MCG124046 26 117 2.23 Down O35945 Aldehyde dehydrogenase 54 552 2.30 Down D3YYI5 Glyceraldehye 3 phosphate dehydrogenase 36 280 2.30 Down O08529 Calpain 2 79 821 2.35 Down P29699 Alpha 2 HS glycoprotein 37 301 2.36...”
- More
S4S7H4 betaine-aldehyde dehydrogenase (EC 1.2.1.8) from Atriplex canescens (see paper)
35% identity, 93% coverage
RHE_RS28200 NAD-dependent succinate-semialdehyde dehydrogenase from Rhizobium etli CFN 42
36% identity, 98% coverage
5abmA / P51977 Sheep aldehyde dehydrogenase 1a1 (see paper)
39% identity, 95% coverage
- Ligand: [[(2r,3s,4r,5r)-5-[(3r)-3-aminocarbonyl-3,4-dihydro-2h-pyridin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanidyl-phosphoryl] [(2r,3s,4r,5r)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl phosphate (5abmA)
Q3U6I3 Aldehyde dehydrogenase, mitochondrial from Mus musculus
39% identity, 90% coverage
gbsA / P71016 betaine aldehyde dehydrogenase subunit (EC 1.2.1.8) from Bacillus subtilis (strain 168) (see paper)
GBSA_BACSU / P71016 Betaine aldehyde dehydrogenase; BADH; Glycine betaine aldehyde dehydrogenase; EC 1.2.1.8 from Bacillus subtilis (strain 168) (see 4 papers)
BSU31060 glycine betaine aldehyde dehydrogenase, NAD+-dependent from Bacillus subtilis subsp. subtilis str. 168
36% identity, 96% coverage
- function: Involved in the biosynthesis of the osmoprotectant glycine betaine from choline (PubMed:8752328, PubMed:9297465). Catalyzes the oxidation of betaine aldehyde to betaine (PubMed:9297465). Shows specificity for betaine aldehyde as substrate. Can use both NAD(+) and NADP(+), but NAD(+) is strongly preferred (PubMed:9297465).
catalytic activity: betaine aldehyde + H2O + NAD(+) = glycine betaine + 2 H(+) + NADH (RHEA:15305)
subunit: Homodimer.
disruption phenotype: Deletion of the gbsAB genes abolishes the choline-glycine betaine synthesis pathway and the ability of B.subtilis to deal effectively with high-osmolarity stress in choline- or glycine betaine aldehyde-containing medium (PubMed:8752328). No effect on vanillin degradation (PubMed:26658822). - rocF affects the production of tetramethylpyrazine in fermented soybeans with Bacillus subtilis BJ3-2
Liu, BMC biotechnology 2022 - “...Up BSU30290 8.444 28.629 1.75 9.44E-04 3.34E-02 Up BSU38080 223.922 747.383 1.74 1.76E-04 9.59E-03 Up BSU31060 17.602 58.817 1.73 2.31E-04 1.16E-02 Up BSU25150 9.698 32.51 1.73 1.03E-03 3.53E-02 Up BSU16740 18.631 61.488 1.72 7.91E-04 2.86E-02 Up BSU32180 5.357 17.113 1.66 1.45E-03 4.43E-02 Up BSU33500 42.669 132.323...”
- Proteomic Response of Bacillus subtilis Spores under High Pressure Combined with Moderate Temperature and Random Peptide Mixture LK Treatment
Pang, Foods (Basel, Switzerland) 2022 - “...c oxidase subunit 2 A0A0G2YRU4 0.02 0.15 Glycine, serine, and threonine metabolism Betaine aldehyde dehydrogenase P71016 0.04 0.14 Aminomethyltransferase P54378 0.04 0.14 l -Serine ammonia-lyase, iron-sulfur-dependent subunit beta A0A8A7MTS3 0.04 0.14 Hydroxymethyltransferase A0A857HNR6 0.04 0.14 Glycine dehydrogenase (Decarboxylating) subunit 1 A0A857HK36 0.04 0.14 NAD-dependent alcohol dehydrogenase...”
BTH_RS10850 NADP-dependent succinate-semialdehyde dehydrogenase from Burkholderia thailandensis E264
Q2T3E1 Succinate-semialdehyde dehydrogenase from Burkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CCUG 48851 / CIP 106301 / E264)
37% identity, 96% coverage
B8AIJ7 Aldehyde dehydrogenase from Oryza sativa subsp. indica
35% identity, 90% coverage
GKP31 glycine betaine aldehyde dehydrogenase from Geobacillus kaustophilus HTA426
37% identity, 93% coverage
sll1561 delta-1-pyrroline-5-carboxylate dehydrogenase from Synechocystis sp. PCC 6803
37% identity, 46% coverage
- Bioinformatic evaluation of L-arginine catabolic pathways in 24 cyanobacteria and transcriptional analysis of genes encoding enzymes of L-arginine catabolism in the cyanobacterium Synechocystis sp. PCC 6803
Schriek, BMC genomics 2007 - “...elongatus BP-1 n.d. Tlr1328, Tlr0408, Tll1935 Tlr0416, Tlr0221 Synechocystis sp. PCC 6803 Sll1077, Sll0228 Slr1022 Sll1561, Slr0370, Slr0091 Gloeobacter violaceus PCC 7421 n.d. Glr0547, Glr3849, Gll2223 Glr2755, Glr3848, Gll1504, Gll2805 Nostoc sp. PCC 7120 Alr2310 Alr2398, Alr1080, All0396 Alr0540, Alr3771, All3556, All5022 Nostoc punctiforme PCC 73102...”
- “...Thermosynechococcus elongatus BP-1 Tll0507 Tlr1328, Tlr0408, Tll1935 Tlr0416, Tlr0221 Synechocystis sp. PCC 6803 Sll1336 Slr1022 Sll1561, Slr0370, Slr0091 Gloeobacter violaceus PCC 7421 Glr1758 Glr0547, Glr3849, Gll2223 Glr2755, Glr3848, Gll1504, Gll2805 Nostoc sp. PCC 7120 Alr4495 Alr2398, Alr1080, All0396 Alr0540, Alr3771, All3556, All5022 Nostoc punctiforme PCC 73102...”
- Arginine catabolism in the cyanobacterium Synechocystis sp. Strain PCC 6803 involves the urea cycle and arginase pathway
Quintero, Journal of bacteriology 2000 - “...argD proC sll0902 sll0228 sll1077 sll1561 slr1022 slr0661 3227266-3226340 148942-148022 801206-800034 1969118-1966146 640737-642026 3338682-3339485...”
- “...a proline auxotroph, was unexpected (see Discussion). ORF sll1561 is the putative Synechocystis putA gene encoding proline oxidase. An insertional mutant of...”
Sb10g023000 No description from Sorghum bicolor
39% identity, 90% coverage
FGSG_00979 aldehyde dehydrogenase from Fusarium graminearum PH-1
37% identity, 96% coverage
- Functional Characterization of Aldehyde Dehydrogenase in Fusarium graminearum
Tang, Microorganisms 2023 - “...are multifunctional. Notably, we found that FGSG_04194 has an inhibitory impact on ALDH activity, whereas FGSG_00979 has a positive impact. RNA sequencing and subcellular location analysis revealed that FGSG_04194 is responsible for biological process regulation, including glucose and lipid metabolism. Our results suggest that ALDH contributes...”
- “...annotated genes coding for aldehyde dehydrogenase ( FGSG_04194 , FGSG_00139 , FGSG_11482 , FGSG_05375 , FGSG_00979 , FGSG_02160 , FGSG_05831 , FGSG_02273 , and FGSG_01759 ) were identified in F. graminearum . It is unclear why efforts to knockout FGSG_ 02273 and FGSG_01759 did not succeed....”
Q69XE0 Cytosolic aldehyde dehydrogenase from Oryza sativa subsp. japonica
38% identity, 90% coverage
SAR_RS11525 aldehyde dehydrogenase family protein from Staphylococcus aureus subsp. aureus MRSA252
SAR2210 aldehyde dehydrogenase family protein from Staphylococcus aureus subsp. aureus MRSA252
38% identity, 97% coverage
- Characterisation and Molecular Analysis of an Unusual Chimeric Methicillin Resistant Staphylococcus Aureus Strain and its Bacteriophages
Burgold-Voigt, Frontiers in genetics 2021 - “...respectively, with recombination breakpoints being situated around SAUR0261 (SAR_RS01305), or positions 279,625..280,329, and between SAUR2305 (SAR_RS11525) and SAUR2306 (SAR_RS11530), i.e., between positions 2,290,040 and 2,290,278 ( Supplementary File S6 ). In conclusion, the observations indicate an integration of a segment that originates from CC140 into a...”
- Staphylococcus aureus nitric oxide synthase (saNOS) modulates aerobic respiratory metabolism and cell physiology
Mogen, Molecular microbiology 2017 - “...In addition, several metabolic genes, including those associated with anaerobic metabolism/fermentation ( pfl, narG, SAR2013, SAR2210 , and ldh2 ), pyruvate and carbohydrate metabolism ( pyk , lac operon, nanA , fda , gap, and pgi ), amino acid metabolism ( SAR1143 , otc , SAR1836...”
- The Staphylococcus aureus response to unsaturated long chain free fatty acids: survival mechanisms and virulence implications
Kenny, PloS one 2009 - “...5.32 1.58E-03 SAR1585 malR maltose operon transcriptional repressor 2.21 2.20E-02 SAR1655 putative methyltransferase 2.25 6.08E-03 SAR2210 aldehyde dehydrogenase family protein 5.48 1.51E-03 SAR2352 moaA putative molybdenum cofactor biosynthesis protein A 2.07 1.86E-03 SAR2385 putative Na+/H+ antiporter 2.35 1.34E-02 SAR2395 inositol monophosphatase family protein 2.90 7.59E-04 SAR2413...”
A0R5S7 Aldehyde dehydrogenase from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)
MSMEG_6297 aldehyde dehydrogenase from Mycobacterium smegmatis str. MC2 155
39% identity, 82% coverage
- Associating H2O2-and NO-related changes in the proteome of Mycobacterium smegmatis with enhanced survival in macrophage.
Ganief, Emerging microbes & infections 2018 - “...gluconeogenesis A0R171 MSMEG_4646 Pyruvate flavodoxin/ferredoxin oxidoreductase-like protein (EC 1.2.7.3) (pyruvate synthase) 1.2.7.3 0.28 Glycolysis/ gluconeogenesis A0R5S7 MSMEG_6297 Aldehyde d ehydrogenase (EC 1.2.-.-) (aldehyde dehydrogenase) 1.2.-.- 0.41 Glycolysis/ gluconeogenesis A0R170 orB Alpha oxoglutarate ferredoxin oxidoreductase, beta subunit N/A 0,49 Lipid metabolism A0R0B5 kasB 3-oxoacyl-(Acyl-carrier-protein) synthase 1 KasA...”
- Associating H2O2-and NO-related changes in the proteome of Mycobacterium smegmatis with enhanced survival in macrophage
Ganief, Emerging microbes & infections 2018 - “...suggest an increase in acetyl-CoA synthesis through the reaction 1.2.7.11 (Supplementary Figure 4 ). However, MSMEG_6297, which is also involved in acetyl-CoA metabolism, was observed to have a decreased abundance. The increased levels of proteins such as KasB and Des (Supplementary Figure 6B ) suggest that...”
- “...A0R171 MSMEG_4646 Pyruvate flavodoxin/ferredoxin oxidoreductase-like protein (EC 1.2.7.3) (pyruvate synthase) 1.2.7.3 0.28 Glycolysis/ gluconeogenesis A0R5S7 MSMEG_6297 Aldehyde d ehydrogenase (EC 1.2.-.-) (aldehyde dehydrogenase) 1.2.-.- 0.41 Glycolysis/ gluconeogenesis A0R170 orB Alpha oxoglutarate ferredoxin oxidoreductase, beta subunit N/A 0,49 Lipid metabolism A0R0B5 kasB 3-oxoacyl-(Acyl-carrier-protein) synthase 1 KasA (3-oxoacyl-[acyl-carrier-protein]...”
B9F3B6 Succinate-semialdehyde dehydrogenase, mitochondrial from Oryza sativa subsp. japonica
35% identity, 90% coverage
- Overexpression of EiKCS confers paraquat-resistance in rice (Oryza sativa L.) by promoting the polyamine pathway
Luo, Pest management science 2022 - “...conversion to spermidine and spermine. The expression levels of the proteins Q69P84 (1.15fold), Q9FRX7 (1.20fold), B9F3B6 (1.24fold), and O04226 (1.13fold), which are mainly associated with the metabolism of putrescine and spermidine, were enhanced. In contrast, that of proteins such as Q6KAJ2 (0.93fold), B9FK36 (0.84fold), and Q0J9M3...”
- “...Mitochondria Aldehyde dehydrogenase (NAD + ) EC 1.2.1.3 K00128 osa00071 Fatty acid degradation and osa00330 B9F3B6 ALDH5F1 Chloroplast Succinatesemialdehyde dehydrogenase EC 1.2.1.24 K17761 osa00250 Alanine, aspartate and glutamate metabolism O04226 P5CS1 Chloroplast Delta1pyrroline5carboxylate synthase 1 EC 1.2.1.41 K12657 osa00330 Arginine and proline metabolism Q6KAJ2 Os02g0797500 Chloroplast...”
- Pluronic F-68 Improves Callus Proliferation of Recalcitrant Rice Cultivar via Enhanced Carbon and Nitrogen Metabolism and Nutrients Uptake.
Kok, Frontiers in plant science 2021 - “...0.72888 15 Protein SPIRAL1-like 3 Q2QQ99 Signaling and Cellular Process 0.69104 16 Succinate-semialdehyde dehydrogenase, mitochondrial B9F3B6 Carbohydrate Metabolism 0.68819 17 ATP synthase subunit beta, mitochondrial Q01859 Transporter Protein 0.68358 18 Elongation factor Ts, mitochondrial Q6ZJS7 Protein Biosynthesis 0.67611 19 Cupincin Q852L2 N/A 0.66449 20 Betaine aldehyde...”
- Global Proteomic Analysis Reveals Widespread Lysine Succinylation in Rice Seedlings
Zhang, International journal of molecular sciences 2019 - “...Half of these overlapping proteins are involved in different metabolic pathways. For examples, succinate-semialdehyde dehydrogenase B9F3B6, isocitrate dehydrogenase Q9SDG5 and Q7XMA0, and glyceraldehyde 3-phosphate dehydrogenase Q0J8A4 and Q7FAH2 participate in carbon metabolism, Q9FRX7 which is an aldehyde dehydrogenase, participates in glycolysis, and nucleoside diphosphate kinase Q5TKF4...”
Smp_050390 aldehyde dehydrogenase,putative from Schistosoma mansoni
G4LWI3 Aldehyde dehydrogenase,putative from Schistosoma mansoni
37% identity, 95% coverage
- Serological screening of the Schistosoma mansoni adult worm proteome
Ludolf, PLoS neglected tropical diseases 2014 - “...zeta isoform Smp_009760 x x x Actin-1 1 Smp_046600 x x x x Aldehyde dehydrogenase Smp_050390 x x x x Antigen Sm 21.7 Smp_086480 x x Annexin 2 Smp_162170.2 x Arginase Smp_059980 x ATP synthase alpha subunit mitochondrial Smp_002880.2 x x ATP synthase beta subunit Smp_038100...”
- Proteomic identification of IPSE/alpha-1 as a major hepatotoxin secreted by Schistosoma mansoni eggs
Abdulla, PLoS neglected tropical diseases 2011 - “...proteasome subunit beta 2 (T01 family) Smp_074500.2 2 11 3.23 1.80E-06 22.8 14 aldehyde dehydrogenase Smp_050390 4 9 1.81 3.00E-04 53.8 8, 19, 26 ++ NAD dependent epimerase/dehydratase Smp_089370 4 16 2.19 7.10E-06 29.8 5, 9, 10 PwLAP aminopeptidase (M17 family) Smp_083870 7 13 1.49 2.90E-05...”
- “...[1] heat shock protein 70 Smp_182190.2 31 41.3 5.61 8.90E-10 69830 3 [1] aldehyde dehydrogenase Smp_050390 5 11.6 4.33 2.10E-07 53763 3 [2] expressed protein Smp_170410 2 4.2 2.7 1.70E-05 29253 4 [1] heat shock protein (Major egg antigen (P40) Smp_049250 10 25.1 4.76 3.30E-08 40192...”
- The genome of the blood fluke Schistosoma mansoni
Berriman, Nature 2009 - “...B Cyclosporine A Smp_044440 alcohol dehydrogenase, putative Fomepizole A Smp_048430 thioredoxin reductase (TGR) Auranofin B Smp_050390 aldehyde dehydrogenase, putative Disulfiram B Smp_053220 aldo-keto reductase, putative Tolrestat A Smp_055890 ribonucleoside-diphosphate reductase small chain, putative Hydroxyurea A , Gemcitabine B Smp_065120 deoxyhypusine synthase, putative Ciclopirox B Smp_069160 cyclophilin,...”
- Effect of Praziquantel on Schistosoma mekongi Proteome and Phosphoproteome
Chienwichai, Pathogens (Basel, Switzerland) 2020 - “...24.7 3.12 5 C1LFP4 Putative aldehyde dehydrogenase 1B1 precursor 53.5 6.06 379 28.9 4.0 6 G4LWI3 Aldehyde dehydrogenase, putative 53.7 5.76 113 19.8 2.86 7 B2LXU3 Glyceraldehyde 3-phosphate dehydrogenase 36.5 7.68 152 33.4 2.63 8 C7TRL1 Glyceraldehyde 3-phosphate dehydrogenase 36.5 8.4 340 33.7 2.63 9 G4M130...”
- “...dehydrogenase Down 35 B2LXU1 Enolase Down 36 C1LFP4 Putative aldehyde dehydrogenase 1B1 precursor Down 37 G4LWI3 Aldehyde dehydrogenase, putative Down 38 A0A095A4B6 Aldehyde dehydrogenase X, mitochondrial Down 39 Q5DAK2 SJCHGC06828 protein Down 40 Q5BXP5 SJCHGC05927 protein, partial Down 41 Q5DAM7 SJCHGC06305 protein Down 42 Q5DFZ8 SJCHGC00411...”
- Known Allergen Structures Predict Schistosoma mansoni IgE-Binding Antigens in Human Infection
Farnell, Frontiers in immunology 2015 - “...Protein Heat shock protein Hsp90 Q26582 Sm Aldehypde dehydrogenase PF00171 Aldehyde dehydrogenase family Aldehyde dehydrogenase G4LWI3 Sm Serpin-like protein PF00079 Serpin (serine protease inhibitor) Serpin serine protease inhibitor G4LZN6 Sm Triosephosphate Isomerase PF00121 Triosephosphate Isomerase Triosephosphate isomerase G4V6B9 Sm Cyclophilin PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD...”
SAUSA300_2076 aldehyde dehydrogenase family protein from Staphylococcus aureus subsp. aureus USA300_FPR3757
SA1924 hypothetical protein from Staphylococcus aureus subsp. aureus N315
SAV2122 aldehyde dehydrogenase from Staphylococcus aureus subsp. aureus Mu50
NWMN_2026 aldehyde dehydrogenase family protein from Staphylococcus aureus subsp. aureus str. Newman
USA300HOU_2110 aldehyde dehydrogenase from Staphylococcus aureus subsp. aureus USA300_TCH1516
SACOL2114 aldehyde dehydrogenase from Staphylococcus aureus subsp. aureus COL
38% identity, 97% coverage
- Novel Regulation of Alpha-Toxin and the Phenol-Soluble Modulins by Peptidyl-Prolyl cis/trans Isomerase Enzymes in Staphylococcus aureus
Keogh, Toxins 2019 - “...Purines, pyrimidines, nucleosides, and nucleotides SAUSA300_0492 FolP 0.47 Biosynthesis of cofactors, prosthetic groups, and carriers SAUSA300_2076 0.46 Central intermediary metabolism SAUSA300_1640 Icd 0.46 Energy metabolism SAUSA300_0841 0.46 Conserved hypothetical protein SAUSA300_2197 RplP 0.45 Protein synthesis SAUSA300_1443 RluB 0.45 Protein synthesis SAUSA300_1159 NusA 0.45 Transcription SAUSA300_1530 YbeY...”
- Sulfide Homeostasis and Nitroxyl Intersect via Formation of Reactive Sulfur Species in Staphylococcus aureus
Peng, mSphere 2017 - “...SA1814 dapE 9.5 Succinyl-diaminopimelate desuccinylase (dinuclear) NWMN_1949 SA1847 scrR 3.1 4.0 Sucrose operon repressor NWMN_2026 SA1924 11.3 Aldehyde dehydrogenase family NWMN_2043 SA1941 25.8 Dps; nonheme Fe-containing ferritin Yes (3.0) NWMN_2044 SA1942 8.0 Hypothetical; predicted disulfide oxidoreductase Yes (2.9) NWMN_2048 SA1946 19.1 Hypothetical NWMN_2059 SA1962 mtlA 14.7...”
- Global regulation of Staphylococcus aureus genes by Rot
Saïd-Salim, Journal of bacteriology 2003 - “...VOL. 185, 2003 615 TABLE 4--Continued Chip ORF no.a SA1924 SA0173 SA2339 SA0310 SA0003 SA1942 SA1016 SA0973 SA1056 SA2256 SA0827 SA0246 SA1131 SA1679 N315 geneb...”
- Protein CoAlation and antioxidant function of coenzyme A in prokaryotic cells
Tsuchiya, The Biochemical journal 2018 - “...147.84 SAKOR_00998 Hydroxymethylpyrimidine transport ATP-binding protein 53.302 VLLLGPSGC*GK 54.898 SAOUHSC_01872 Uncharacterized protein 46.176 C*SQFVYK 68.657 SAV2122 Putative aldehyde dehydrogenase SAV2122 51.968 VVNNTGQVC*TAGTR 225.69 SAOUHSC_02064 Phi ETA orf 25-like protein 15.401 DVNLTWIC*K 79.089 HUNSC491_pPR9_p11 ATP-binding protein p271 (ATP-binding protein, putative) 7.4555 YQYIGIC*YGQPGVGK 91.065 AYM28_02415 Acetyltransferase (GNAT) family...”
- Quantitative proteomic view associated with resistance to clinically important antibiotics in Gram-positive bacteria: a systematic review
Lee, Frontiers in microbiology 2015 - “...only Metal-dependent hydrolase SA1529 Met Down 1 Cordwell et al., 2002 Protein degradation Aldehyde dehydrogenase SAV2122 Met Up 1 Enany et al., 2014 Energy metabolism Putative transaldolase tal Van Down 1 Drummelsmith et al., 2007 Energy metabolism Putative transcription factor SA2296 Van Up 1 Scherl et...”
- Citrate serves as a signal molecule to modulate carbon metabolism and iron homeostasis in Staphylococcus aureus
Chen, PLoS pathogens 2024 - “...markedly increased expression of genes, such as butA , NWMN_2459 , lctP1 , NWMN_1315 , NWMN_2026 , adh1 , pflB , and fdhA , associated with fermentation pathways [ 56 , 57 ] ( S5 Fig ). Additionally, in the pathway from pyruvate to L-leucine through...”
- Transcriptional Response of Staphylococcus aureus to Sunlight in Oxic and Anoxic Conditions
McClary, Frontiers in microbiology 2018 - “...agrC Staphylococcal accessory gene regulator protein C 0.41 12.1 NWMN_1806 Conserved hypothetical protein 0.39 24.8 NWMN_2026 Aldehyde dehydrogenase family protein 0.38 12.6 glnA Glutamine synthetase 0.38 8.6 gapR Glycolytic operon regulator 0.36 13.0 citC Isocitrate dehydrogenase, NADP-dependent 0.36 19.2 NWMN_1263 Aconitate hydratase 0.35 21.7 NWMN_0845 ATP-dependent...”
- Sulfide Homeostasis and Nitroxyl Intersect via Formation of Reactive Sulfur Species in Staphylococcus aureus
Peng, mSphere 2017 - “...NWMN_1929 SA1814 dapE 9.5 Succinyl-diaminopimelate desuccinylase (dinuclear) NWMN_1949 SA1847 scrR 3.1 4.0 Sucrose operon repressor NWMN_2026 SA1924 11.3 Aldehyde dehydrogenase family NWMN_2043 SA1941 25.8 Dps; nonheme Fe-containing ferritin Yes (3.0) NWMN_2044 SA1942 8.0 Hypothetical; predicted disulfide oxidoreductase Yes (2.9) NWMN_2048 SA1946 19.1 Hypothetical NWMN_2059 SA1962 mtlA...”
- Functional expression and extension of staphylococcal staphyloxanthin biosynthetic pathway in Escherichia coli
Kim, The Journal of biological chemistry 2012 - “...dehydrogenase 2 Glycine betaine aldehyde dehydrogenase NWMN_2026 aldA aldH asd gapA gapB gbsA NWMN_2026 NWMN_0113 NWMN_1858 NWMN_1305 NWMN_0741...”
- “...dehydrogenase homolog (aldA), and aldehyde dehydrogenase family protein (NWMN_2026). These genes were then cloned from S. aureus and expressed by the 21580...”
- Protein S-Bacillithiolation Functions in Thiol Protection and Redox Regulation of the Glyceraldehyde-3-Phosphate Dehydrogenase Gap in Staphylococcus aureus Under Hypochlorite Stress
Imber, Antioxidants & redox signaling 2018 - “...36.20 0.28 USA300HOU_0610 adh Alcohol DH Cys37 a B 2.3 25.18 11.02 0.35 36.20 0.28 USA300HOU_2110 aldA Aldehyde DH Cys279 a (-SSB) B 1.4 26.29 11.14 0.14 37.43 0.06 USA300HOU_2291 fdhA Formate DH alpha subunit Cys386 a B 15.8 13.68 47.82 0.07 61.50 0.09 Tricarboxyclic acid...”
- “...(G3P) dehydrogenase Gap and phosphofructokinase PfkA (USA300HOU_1685), the alcohol dehydrogenase Adh, the aldehyde dehydrogenase AldA (USA300HOU_2110), the formate dehydrogenase FdhA (USA300HOU_2291), and the malate dehydrogenase Mqo (USA300HOU_2348). Gap and AldA both showed the highest oxidation increase of 29% and 26% under NaOCl stress at their catalytic...”
- The aldehyde dehydrogenase AldA contributes to the hypochlorite defense and is redox-controlled by protein S-bacillithiolation in Staphylococcus aureus
Imber, Redox biology 2018 - “...50M methylhydroquinone (MHQ) for 15 and 30min and subjected to Northern blot analysis for aldA (SACOL2114) transcription. (B) For comparison of Northern blot analysis of aldA transcription between the wild type and the sigB mutant, RNA was isolated from S. aureus COL wild type and the...”
Q155V4 betaine-aldehyde dehydrogenase (EC 1.2.1.8) from Suaeda salsa (see paper)
Q8W5A1 betaine-aldehyde dehydrogenase (EC 1.2.1.8) from Suaeda liaotungensis (see 2 papers)
35% identity, 93% coverage
5gtkA NAD+ complex structure of aldehyde dehydrogenase from bacillus cereus
36% identity, 96% coverage
- Ligand: nicotinamide-adenine-dinucleotide (5gtkA)
4v37A / P17202 Crystal structure of betaine aldehyde dehydrogenase from spinach showing a thiohemiacetal with 3-aminopropionaldehyde
34% identity, 94% coverage
- Ligands: nicotinamide-adenine-dinucleotide; 3-aminopropan-1-ol (4v37A)
YPK_2459 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase from Yersinia pseudotuberculosis YPIII
35% identity, 97% coverage
- HpaR, the Repressor of Aromatic Compound Metabolism, Positively Regulates the Expression of T6SS4 to Resist Oxidative Stress in Yersinia pseudotuberculosis
Wang, Frontiers in microbiology 2020 - “...YPK_2456 HpaH 2-Oxo-hept-3-ene-1,7-dioate hydratase 3.91 YPK_2457 HpaF 5-Carboxymethyl-2-hydroxymuconate isomerase 4.25 YPK_2458 HpaD 3,4-Dihydroxyphenylacetate 2,3-dioxygenase 4.42 YPK_2459 HpaE 5-Carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase 4.45 YPK_2460 HpaG2 2-Hydroxyhepta-2,4-diene-1,7-dioate isomerase 4.56 YPK_2461 HpaG1 2-Hydroxyhepta-2,4-diene-1,7-dioate isomerase 4.50 *Fold change: log 2 ( hpaR /WT). TABLE 2 T6SS4 genes regulated by HpaR in Y....”
NP_001068835 aldehyde dehydrogenase, mitochondrial precursor from Bos taurus
P20000 Aldehyde dehydrogenase, mitochondrial from Bos taurus
38% identity, 90% coverage
- miR-224 Affects Mammary Epithelial Cell Apoptosis and Triglyceride Production by Downregulating ACADM and ALDH2 Genes.
Shen, DNA and cell biology 2017 (PubMed)- GeneRIF: ACADM and ALDH2 were predicted to be the target genes of miR-224
- Formation of Nitric Oxide by Aldehyde Dehydrogenase-2 Is Necessary and Sufficient for Vascular Bioactivation of Nitroglycerin.
Opelt, The Journal of biological chemistry 2016 - GeneRIF: ALDH2-catalyzed NO formation is necessary and sufficient for nitroglycerin bioactivation in vascular smooth muscle cells.
- Comparative genomics, molecular evolution and computational modeling of ALDH1B1 and ALDH2
Jackson, Chemico-biological interactions 2013 - “...8:20,270,52520,285,138 13 (ve) * 14,614 56,660 na 129 93 71 66 Cow Bos taurus 2 NP_001068835 BC116084 P20000 520 17:64,552,47564,577,817 13 (ve) 25,343 56,653 na 121 93 74 67 Opossum Monodelphis domestica 2 XP_003340827 a na na 518 3:482,516,060482,539,080 13 (ve) 23,021 56,689 na 117 90...”
- Bioactivation of nitroglycerin by purified mitochondrial and cytosolic aldehyde dehydrogenases.
Beretta, The Journal of biological chemistry 2008 - GeneRIF: analysis of bioactivation of nitroglycerin by purified mitochondrial and cytosolic aldehyde dehydrogenases ALDH1 and ALDH2
- Proteome Analysis Related to Unsaturated Fatty Acid Synthesis by Interfering with Bovine Adipocyte ACSL1 Gene
, Antioxidants (Basel, Switzerland) 2024 - “...A0A3Q1M066, A5D7T5 map00071 Fatty acid degradation 0.0228 P48818, Q17QI3, A0A3S5ZP98, A0A3Q1NDR1, Q3T0R7, F1N1M7, Q3ZC42, A0A3Q1LZB8, P20000, Q2KJH9 map00561 Glycerol metabolism 0.0289 A0A3S5ZP98, A0A3Q1LZB8, P20000, Q2KJH9, A0A3Q1MGZ4, E1BGF8 map04910 Insulin signaling pathway 0.0416 A0A3Q1M168, A0A3Q1M0F0, F1MDS3, Q3SWW9, P00515, Q3T0E7, P46196, A0A3Q1MNN7, E1BME6, F1MU24, P00514, B0JYK4, A2VDU0, I7CLV3,...”
- Characterization of the Testis-Specific Angiotensin Converting Enzyme (tACE)-Interactome during Bovine Sperm Capacitation
Ojaghi, Current issues in molecular biology 2022 - “...(SD) Normalized Spectral Count in Fresh Sperm Mean (SD) Normalized Spectral Count in Capacitated Sperm P20000 Aldehyde dehydrogenase, mitochondrial ALDH2 Oxidoreductase; NAD binding; 5-Hydroxytryptamine degradation 0 0 15.12 3.66 Q2YDN8 Inactive serine/threonine-protein kinase VRK3 Protein phosphorylation; Vesicle-mediated transport signal transduction; Membrane organization 0 0 10.10 3.45...”
- Protein acetylation in mitochondria plays critical functions in the pathogenesis of fatty liver disease
Le-Tian, BMC genomics 2020 - “...( n =6) 0.0191 P05307 P4HB 11 6 387 NFEEVAFDEK(1)K 0.560.06 ( n =6) 0.0151 P20000 ALDH2 11 6 371 TEQGPQVDETQFK(1)K 1.260.29 ( n =6)) 0.0176 O46629 HADHB 10 6 189 MMLDLNK(1)AK(1)TLAQR 1.430.34 ( n =6) 0.0350 Q0VCM4 PYGL 9 6 465 IHSDIVK(1)TQVFK 0.610.08 ( n...”
- Proteomic changes in the milk of water buffaloes (Bubalus bubalis) with subclinical mastitis due to intramammary infection by Staphylococcus aureus and by non-aureus staphylococci
Pisanu, Scientific reports 2019 - “...b 1.61 1.75 IM Q3T035 Actin-related protein 2/3 complex subunit 3* ,a 1.57 1.71 S P20000 Aldehyde dehydrogenase, mitochondrial* ,a 1.57 1.71 CM P01030 Complement C4 b 1.57 1.72 I P0C0S4 Histone H2A.Z a 1.56 1.66 S Q27996 Lysozyme C, tracheal isozyme 1.56 1.51 1.61 I...”
- Reconstruction of insect hormone pathways in an aquatic firefly, Sclerotia aquatilis (Coleoptera: Lampyridae), using RNA-seq.
Chanchay, PeerJ 2019 - “...Q8IZ83 2 0 0 0 Q2XQV4 2 0 0 0 O94788 1 0 0 0 P20000 1 0 0 0 P51648 1 0 0 0 P27463 1 0 0 1 K10718 JHAMT 29 Q9NBX5 1 18 9 1 Q9TYP1 1 0 0 0 Q54XD0 1 0...”
- Neutrophil extracellular traps in sheep mastitis.
Pisanu, Veterinary research 2015 - “...Cellular retinoic acid-binding protein 2 O 1.54 Mitochondrion P45879 Voltage-dependent anion-selective channel protein 1 4.74 P20000 Aldehyde dehydrogenase, mitochondrial 3.90 Q9Y6N5 Sulfide:quinone oxidoreductase, mitochondrial 3.69 Q9MZ13 Voltage-dependent anion-selective channel protein 3 3.43 Q9UKU0 Long-chain-fatty-acid-CoA ligase 6 3.26 P41976 Superoxide dismutase [Mn], mitochondrial 3.17 Q3T165 Prohibitin 3.11...”
- Production and release of antimicrobial and immune defense proteins by mammary epithelial cells following Streptococcus uberis infection of sheep
Addis, Infection and immunity 2013 - “...P05164 Q3SWX7 P02544 P21333 Q92176 Q258K2 P28783 Q1JPB0 P20000 P20700 Q8SPQ0 P27214 O46522 P47843 Integrin beta-2 Myeloperoxidase Annexin A3 Vimentin Filamin A...”
- Comparative genomics, molecular evolution and computational modeling of ALDH1B1 and ALDH2
Jackson, Chemico-biological interactions 2013 - “...(ve) * 14,614 56,660 na 129 93 71 66 Cow Bos taurus 2 NP_001068835 BC116084 P20000 520 17:64,552,47564,577,817 13 (ve) 25,343 56,653 na 121 93 74 67 Opossum Monodelphis domestica 2 XP_003340827 a na na 518 3:482,516,060482,539,080 13 (ve) 23,021 56,689 na 117 90 75 70...”
- More
lmo0383 highly similar to B. subtilis methylmalonate-semialdehyde dehydrogenase IolA from Listeria monocytogenes EGD-e
36% identity, 97% coverage
- Prebiotic Oligosaccharides Potentiate Host Protective Responses against L. Monocytogenes Infection
Chen, Pathogens (Basel, Switzerland) 2017 - “...0.022 serC , lmo2101 Amino acid metabolism Amino Acids Degradation 0.006 gltD, aspB, lmo2836, lmo2363, lmo0383, lmo1182, lmo2101, lmo2749, lmo1915 Proteinogenic Amino Acids Degradation 0.006 L-aspartate Degradation 0.022 aspB , lmo1915 Aspartate degradation II 0.022 Aspartate superpathway 0.047 nadE, nadD, aspB , lmo1436, lmo1437 Pyrimidine deoxyribonucleosides...”
- “...Energy metabolism Degradation/Utilization/Assimilation 0.026 gltD, aspB , lmo0347, lmo2696, lmo1057, lmo2648, lmo2836, lmo1463, lmo0877, lmo1182, lmo0383, lmo2101, lmo2749, lmo0372, lmo0917, lmo2771, lmo2840, lmo1915, lmo2362, lmo2095, lmo2835 Secondary metabolite degradation Taxiphyllin bioactivation 0.028 lmo0372, lmo0917, lmo2771 Nitrogen Containing Glucosides Degradation 0.028 Cyanogenic Glucosides Degradation 0.028 Nitrogen Containing...”
- Functional γ-Aminobutyrate Shunt in Listeria monocytogenes: role in acid tolerance and succinate biosynthesis
Feehily, Applied and environmental microbiology 2013 - “...a secondary SSDH also revealed a likely candidate in Lmo0383, which has 54% similarity and 33% identity to the corresponding SSDH (GabD) in E. coli. Further...”
- A postgenomic appraisal of osmotolerance in Listeria monocytogenes
Sleator, Applied and environmental microbiology 2003 - “...exhibiting significant sequence similarities to gbsA (lmo0913, lmo0383, and lmo1179) and gbsB (pduQ, lmo1634, lmo1166, and lmo0554), encoding a glycine betaine...”
AL1A1_BOVIN / P48644 Aldehyde dehydrogenase 1A1; 3-deoxyglucosone dehydrogenase; ALDH-E1; ALHDII; Aldehyde dehydrogenase family 1 member A1; Aldehyde dehydrogenase, cytosolic; Retinal dehydrogenase 1; RALDH 1; RalDH1; EC 1.2.1.19; EC 1.2.1.28; EC 1.2.1.3; EC 1.2.1.36 from Bos taurus (Bovine) (see paper)
39% identity, 94% coverage
- function: Cytosolic dehydrogenase that catalyzes the irreversible oxidation of a wide range of aldehydes to their corresponding carboxylic acid (PubMed:7786847). Functions downstream of retinol dehydrogenases and catalyzes the oxidation of retinaldehyde into retinoic acid, the second step in the oxidation of retinol/vitamin A into retinoic acid (PubMed:7786847). This pathway is crucial to control the levels of retinol and retinoic acid, two important molecules which excess can be teratogenic and cytotoxic (Probable). Also oxidizes aldehydes resulting from lipid peroxidation like (E)-4-hydroxynon-2- enal/HNE, malonaldehyde and hexanal that form protein adducts and are highly cytotoxic. By participating for instance to the clearance of (E)-4-hydroxynon-2-enal/HNE in the lens epithelium prevents the formation of HNE-protein adducts and lens opacification. Functions also downstream of fructosamine-3-kinase in the fructosamine degradation pathway by catalyzing the oxidation of 3-deoxyglucosone, the carbohydrate product of fructosamine 3-phosphate decomposition, which is itself a potent glycating agent that may react with lysine and arginine side-chains of proteins (By similarity). Has also an aminobutyraldehyde dehydrogenase activity and is probably part of an alternative pathway for the biosynthesis of GABA/4-aminobutanoate in midbrain, thereby playing a role in GABAergic synaptic transmission (By similarity).
catalytic activity: an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH (RHEA:16185)
catalytic activity: all-trans-retinal + H2O + NAD(+) = all-trans-retinoate + 2 H(+) + NADH (RHEA:42080)
catalytic activity: 9-cis-retinal + H2O + NAD(+) = 9-cis-retinoate + 2 H(+) + NADH (RHEA:42084)
catalytic activity: 11-cis-retinal + H2O + NAD(+) = 11-cis-retinoate + 2 H(+) + NADH (RHEA:47132)
catalytic activity: 13-cis-retinal + H2O + NAD(+) = 13-cis-retinoate + 2 H(+) + NADH (RHEA:67332)
catalytic activity: 3-deoxyglucosone + H2O + NAD(+) = 2-dehydro-3-deoxy-D- gluconate + 2 H(+) + NADH (RHEA:67244)
catalytic activity: (E)-4-hydroxynon-2-enal + H2O + NAD(+) = (E)-4-hydroxynon-2- enoate + 2 H(+) + NADH (RHEA:67248)
catalytic activity: H2O + malonaldehyde + NAD(+) = 3-oxopropanoate + 2 H(+) + NADH (RHEA:67252)
catalytic activity: H2O + hexanal + NAD(+) = 2 H(+) + hexanoate + NADH (RHEA:67276)
catalytic activity: H2O + NAD(+) + propanal = 2 H(+) + NADH + propanoate (RHEA:67256)
catalytic activity: acetaldehyde + H2O + NAD(+) = acetate + 2 H(+) + NADH (RHEA:25294)
catalytic activity: benzaldehyde + H2O + NAD(+) = benzoate + 2 H(+) + NADH (RHEA:11840)
catalytic activity: 4-aminobutanal + H2O + NAD(+) = 4-aminobutanoate + 2 H(+) + NADH (RHEA:19105)
subunit: Homotetramer (By similarity). Interacts with PRMT3; the interaction is direct, inhibits ALDH1A1 aldehyde dehydrogenase activity and is independent of the methyltransferase activity of PRMT3 (By similarity). - A 3D endometrium-on-a-chip reveals the role of conceptus-derived factors CAPG and PDI in conceptus-endometrial communication
Tinning, 2024 - Proteomic and computational analyses followed by functional validation of protective effects of trigonelline against calcium oxalate-induced renal cell deteriorations.
Peerapen, Computational and structural biotechnology journal 2023 - “...Rab-1B Q9H0U4 RAB1B 70.79 54.2 5/11 22.17 28.831.14 33.331.01 1.1558 0.0095 2.1429 Retinal dehydrogenase 1 P48644 ALDH1A1 16.42 10.6 1/4 54.81 5.280.70 2.051.05 0.3887 0.0208 1.9586 RuvB-like 1 Q9Y265 RUVBL1 33.88 37.3 13/13 50.23 26.120.47 24.560.50 0.9402 0.0376 1.8400 Small nuclear ribonucleoprotein F Q3T0Z8 SNRPF 5.98...”
- Proteins from toad's parotoid macroglands: do they play a role in gland functioning and chemical defence?
Kowalski, Frontiers in zoology 2023 - “...5 ATP synthase subunit alpha, mitochondrial Aging, apoptosis, lipid metabolism, electron transport 5, 7, 8 P48644 191 55,276 4 3 Retinal dehydrogenase 1 Oxidoreductase activity 8 Q8HZM6 177 38,943 3 3 Annexin A1 Innate and adaptive immune response, actin cytoskeleton organisation 4, 10 P51857 175 37,629...”
- Identification of 56 Proteins Involved in Embryo-Maternal Interactions in the Bovine Oviduct
Banliat, International journal of molecular sciences 2020 - “...A1A4J1 85 4.9 RPL6 60S ribosomal protein L6 Q58DQ3 33 4.5 ALDH1A1 Retinal dehydrogenase 1 P48644 55 2.9 PPP2R1A Alpha isoform of regulatory subunit A. protein phosphatase 2 Q32PI5 65 2.3 ANXA5 Annexin A5 P81287 36 2.3 1 Protein detected only in OF-treated embryos. ijms-21-00466-t002_Table 2...”
- Naturally Produced Lovastatin Modifies the Histology and Proteome Profile of Goat Skeletal Muscle.
Leo, Animals : an open access journal from MDPI 2019 - “...and a half LIM domains protein 1 3.01 3.9 K0J107 Malate dehydrogenase, mitochondrial 2.93 3.06 P48644 Retinal dehydrogenase 1 2.5 4.3 P19858 L-lactate dehydrogenase A chain 2.46 3.26 Q148F1 Cofilin-2 2.35 2.89 P13707 Glycerol-3-phosphate dehydrogenase [NAD( + )], cytoplasmic 2.23 2.49 Q99497 Protein DJ-1 1.99 2.63...”
- Beef tenderness and intramuscular fat proteomic biomarkers: muscle type effect.
Picard, PeerJ 2018 - “...Mo. anti-human Abnova Eno3 (M01), clone 5D1 1/30 000 Retinal dehydrogenase 1 ( ALDH1A1 ) P48644 Po. anti-bovine Abcam ab23375 1/500 Triosephosphate isomerase ( TPI1 ) Q5E956 Po. anti-human Novus NBP1-31470 1/50 000 Phosphoglycerate kinase 1 ( PGK1 ) Q3T0P6 Po. anti-human Abcam ab90787 1/5000 Fructose-bisphosphate...”
P27463 retinal dehydrogenase (EC 1.2.1.36) from Gallus gallus (see 2 papers)
39% identity, 92% coverage
- Metalloproteomic analysis of liver proteins isolated from broilers fed with different sources and levels of copper and manganese
Aparecida, Scientific reports 2024 - “...6.17/47,305.01 380.7553 High Cu/Mn SO 4 =Mn P07322 ENO3 Beta-enolase 7.28/47,196.08 247.165 High Cu/Mn (OH)Cl=Mn P27463 ALDH1A1 Retinal dehydrogenase 1 7.49/55,809.33 66.4081 10 O93344 ALDH1A2 Retinal dehydrogenase 2 5.87/56,731.99 66.4081 P51913 ENO1 Alpha-enolase 6.65/43,874 6.17/47,305.01 10,775.61 High Cu/Mn SO 4 =CuHigh Cu/Mn (OH)Cl=Cu O57391 ENO2 Gamma-enolase...”
- “...GLUD1 Glutamate dehydrogenase 1, mitochondrial 7.82/51,213 8.48/55,712.06 2828.28 High Cu/Mn SO 4 =Cu e Mn P27463 ALDH1A1 Retinal dehydrogenase 1 7.49/55,809.33 2341.783 P07341 ALDOB Fructose-bisphosphate aldolase B 8.81/39,295.78 299.201 High Cu/Mn (OH)Cl=Cu e Mn O93344 ALDH1A2 Retinal dehydrogenase 2 5.87/56,731.99 155.6904 26 Q5ZJF4 PRDX6 Peroxiredoxin-6 6.65/25,240...”
- Characterization of the Effects of Low-Sodium Salt Substitution on Sensory Quality, Protein Oxidation, and Hydrolysis of Air-Dried Chicken Meat and Its Molecular Mechanisms Based on Tandem Mass Tagging-Labeled Quantitative Proteomics.
Li, Foods (Basel, Switzerland) 2024 - “...transferase A0A3Q2TYR0 MYOZ3 Myozenin 3 E1C312 CAPN6 Calpain 6 A0A8V0YZK6 NMNAT1 Retinol binding protein 7 P27463 ALDH1A1 Aldehyde dehydrogenase 1A1 A0A8V1AEN9 DPP7 Dipeptidyl peptidase 7...”
- Effect of Dietary Betaine on Muscle Protein Deposition, Nucleic Acid and Amino Acid Contents, and Proteomes of Broilers
Chen, Animals : an open access journal from MDPI 2022 - “...1.337 0.046 A0A3Q2U578 Histone H3 N/A 1.205 0.019 A0A1D5NY17 Transmembrane protein 182 TMEM182 1.223 0.033 P27463 Retinal dehydrogenase 1 ALDH1A1 1.502 0.050 P25324 Thiosulfate sulfurtransferase TST 1.259 0.017 Q90579 Anion exchange protein N/A 1.649 0.016 Q5F3G6 PHD finger protein 20-like protein 1 PHF20L1 1.538 0.007 Q8QGU2...”
- Reconstruction of insect hormone pathways in an aquatic firefly, Sclerotia aquatilis (Coleoptera: Lampyridae), using RNA-seq.
Chanchay, PeerJ 2019 - “...O94788 1 0 0 0 P20000 1 0 0 0 P51648 1 0 0 0 P27463 1 0 0 1 K10718 JHAMT 29 Q9NBX5 1 18 9 1 Q9TYP1 1 0 0 0 Q54XD0 1 0 2 0 Q91WU5 1 0 0 0 A2APY7 1 1...”
LMOf2365_0395 methylmalonate-semialdehyde dehydrogenase from Listeria monocytogenes str. 4b F2365
36% identity, 97% coverage
LOC114357983 aldehyde dehydrogenase X, mitochondrial-like from Ostrinia furnacalis
38% identity, 96% coverage
XP_623084 aldehyde dehydrogenase, mitochondrial from Apis mellifera
39% identity, 92% coverage
mmsA / P42412 (methyl)malonate-semialdehyde dehydrogenase monomer (EC 1.2.1.27; EC 1.2.1.18) from Bacillus subtilis (strain 168) (see 4 papers)
IOLA_BACSU / P42412 Malonate-semialdehyde dehydrogenase; MSA dehydrogenase; Methylmalonate-semialdehyde dehydrogenase; MMSA dehydrogenase; MMSDH; MSDH; EC 1.2.1.27 from Bacillus subtilis (strain 168) (see 5 papers)
P42412 methylmalonate-semialdehyde dehydrogenase (CoA-acylating) (EC 1.2.1.27) from Bacillus subtilis (see paper)
NP_391855 methylmalonate-semialdehyde dehydrogenase from Bacillus subtilis subsp. subtilis str. 168
35% identity, 97% coverage
- function: Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively (PubMed:16332250, PubMed:18310071, PubMed:21515690). Is involved in a myo-inositol catabolic pathway (PubMed:18310071). Bicarbonate, and not CO2, is the end-product of the enzymatic reaction (PubMed:16332250).
catalytic activity: 3-oxopropanoate + CoA + H2O + NAD(+) = acetyl-CoA + H(+) + hydrogencarbonate + NADH (RHEA:76615)
catalytic activity: 2-methyl-3-oxopropanoate + CoA + H2O + NAD(+) = H(+) + hydrogencarbonate + NADH + propanoyl-CoA (RHEA:20804)
subunit: Homotetramer.
disruption phenotype: No effect on vanillin degradation. - Mechanistic characterization of the MSDH (methylmalonate semialdehyde dehydrogenase) from Bacillus subtilis.
Stines-Chaumeil, The Biochemical journal 2006 - GeneRIF: A detailed mechanistic characterization of the MSDH-catalysed reaction has been carried out.
PSHAb0219 aldehyde dehydrogenase family protein from Pseudoalteromonas translucida
36% identity, 93% coverage
- Anti-Biofilm Activity of a Long-Chain Fatty Aldehyde from Antarctic Pseudoalteromonas haloplanktis TAC125 against Staphylococcus epidermidis Biofilm
Casillo, Frontiers in cellular and infection microbiology 2017 - “...and P. haloplanktis TAC125-b0219 mutant construction PCR was employed to amplify a DNA fragment of PSHAb0219 gene. P. haloplanktis TAC125 genomic DNA was used as PCR template and two primers were designed to amplify a 275 bp-long region of the PHSAb0219 gene and to introduce an...”
- “...(EC1.11.1.3, Martin and Stumpf, 1959 ). However, the analysis allowed the identification of a gene (PSHAb0219) coding for an aldehyde dehydrogenase B (EC1.2.1.3), an enzyme annotated as a reversible aldehyde oxidoreductase NAD(P) + -dependent with a wide specificity ( http://www.genoscope.cns.fr/agc/microscope/mage/viewer.php ). The aldehyde oxidoreductase, in specific...”
P81178 Aldehyde dehydrogenase, mitochondrial from Mesocricetus auratus
39% identity, 94% coverage
P47738 aldehyde dehydrogenase (NAD+) (EC 1.2.1.3) from Mus musculus (see 4 papers)
Q544B1 Aldehyde dehydrogenase, mitochondrial from Mus musculus
NP_033786 aldehyde dehydrogenase, mitochondrial isoform 1 precursor from Mus musculus
39% identity, 90% coverage
- Decreased Klotho Expression Causes Accelerated Decline of Male Fecundity through Oxidative Injury in Murine Testis.
Wang, Antioxidants (Basel, Switzerland) 2023 - “...mitochondrial 0.844 Q9CZS1 Tpi1 Triosephosphate isomerase 0.679 P17751; P17751-2; H7BXC3 Aldh2 Aldehyde dehydrogenase, mitochondrial 0.610 Q544B1; Q3UJW1; Q3U9J7; P47738; A0A0G2JEU1; Q3U6I3; Q3TVM2 MCODE_4 PPAR signaling pathway Fabp3 Fatty acid-binding protein, heart 2.254 Q5EBJ0; P11404 Me1 Malic enzyme; NADP-dependent malic enzyme 0.703 Q99LF5; Q921S3; P06801; Q3TQP6 Apoa1...”
- Human ApoE ɛ2 Promotes Regulatory Mechanisms of Bioenergetic and Synaptic Function in Female Brain: A Focus on V-type H+-ATPase.
Woody, Journal of Alzheimer's disease : JAD 2016 - “...kinase, B-type Q04447 Ckb 29% 10 0.62 0.033 7 Aldehyde dehydrogenase 2, mitochondrial, isoform CRA_b Q544B1 Aldh2 12% 5 0.70 0.025 8 Glycerol-3-phosphate dehydrogenase [NAD(+)] B2RSR7 Gpd1l 13% 4 2.70 0.020 Synaptic Transmission 2 V-type proton ATPase subunit B, brain isoform P62814 Atp6v1b2 17% 7 1.67...”
- Multifactorial comparative proteomic study of cytochrome P450 2E1 function in chronic alcohol administration.
Wang, PloS one 2014 - “...** oxidation reduction 1.95 - Q3UKT3 Putative uncharacterized protein Oat amino acid metabolism 1.87 - Q544B1 Aldehyde dehydrogenase 2 Aldh2 * alcohol metabolism 1.79 - Q546G4 Albumin 1 Krt8 * developmental process 1.63 2.07 Q3TCQ3 Putative uncharacterized protein Pcx energy production 1.57 - A2A6J8 Troponin I,...”
- “...0.211 2 Q3UKT3 Putative uncharacterized protein Oat amino acid metabolism 1.87 0.001 0.61 0.737 2 Q544B1 Aldehyde dehydrogenase 2 Aldh2 alcohol metabolism 1.79 0.000 0.69 0.064 2 A2A6J8 Troponin I, skeletal, fast 2 Tnni2 developmental process 1.57 0.003 0.01 0.007 2 Q91XD4 Formimidoyltransferase-cyclodeaminase Ftcd fatty acid...”
- Aldehyde dehydrogenase 2 deficiency reinforces formaldehyde-potentiated pro-inflammatory responses and glycolysis in macrophages.
Ma, Journal of biochemical and molecular toxicology 2024 (PubMed)- GeneRIF: Aldehyde dehydrogenase 2 deficiency reinforces formaldehyde-potentiated pro-inflammatory responses and glycolysis in macrophages.
- Mitochondrial aldehyde dehydrogenase rescues against diabetic cardiomyopathy through GSK3β-mediated preservation of mitochondrial integrity and Parkin-mediated mitophagy.
Zhang, Journal of molecular cell biology 2024 - GeneRIF: Mitochondrial aldehyde dehydrogenase rescues against diabetic cardiomyopathy through GSK3beta-mediated preservation of mitochondrial integrity and Parkin-mediated mitophagy.
- ALDH2 deficiency exacerbates MCD-diet induced MASLD by modulating bile acid metabolism.
Luo, Free radical biology & medicine 2024 (PubMed)- GeneRIF: ALDH2 deficiency exacerbates MCD-diet induced MASLD by modulating bile acid metabolism.
- Aldehyde dehydrogenase 2 serves as a key cardiometabolic adaptation regulator in response to plateau hypoxia in mice.
Gao, Translational research : the journal of laboratory and clinical medicine 2024 (PubMed)- GeneRIF: Aldehyde dehydrogenase 2 serves as a key cardiometabolic adaptation regulator in response to plateau hypoxia in mice.
- LncRNA CHKB-DT Downregulation Enhances Dilated Cardiomyopathy Through ALDH2.
Nie, Circulation research 2024 (PubMed)- GeneRIF: LncRNA CHKB-DT Downregulation Enhances Dilated Cardiomyopathy Through ALDH2.
- Aldehyde Dehydrogenase 2 (ALDH2) Deficiency, Obesity, and Atrial Fibrillation Susceptibility: Unraveling the Connection.
Hsu, International journal of molecular sciences 2024 - GeneRIF: Aldehyde Dehydrogenase 2 (ALDH2) Deficiency, Obesity, and Atrial Fibrillation Susceptibility: Unraveling the Connection.
- Neutrophil ALDH2 is a new therapeutic target for the effective treatment of sepsis-induced ARDS.
Xu, Cellular & molecular immunology 2024 - GeneRIF: Neutrophil ALDH2 is a new therapeutic target for the effective treatment of sepsis-induced ARDS.
- Aldehyde Dehydrogenase 2 Deficiency Aggravates Lung Fibrosis through Mitochondrial Dysfunction and Aging in Fibroblasts.
Wei, The American journal of pathology 2024 (PubMed)- GeneRIF: Aldehyde Dehydrogenase 2 Deficiency Aggravates Lung Fibrosis through Mitochondrial Dysfunction and Aging in Fibroblasts.
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- Branched-Chain Amino Acid Degradation Pathway was Inactivated in Colorectal Cancer: Results from a Proteomics Study
Lian, Journal of Cancer 2024 - “...cancer datasets* P38060 Hmgcl Hydroxymethylglutaryl-CoA lyase, mitochondrial 5.85 2 1.02 0.5 0.58 NA 0.072 Yes P47738 Aldh2 Aldehyde dehydrogenase, mitochondrial 27.36 17 1.01 0.5 0.56 Down 0.65 Yes P54869 Hmgcs2 Hydroxymethylglutaryl-CoA synthase, mitochondrial 27.17 20 1.01 0.32 0.28 Down 0.016 Yes Q07417 Acads Short-chain specific acyl-CoA...”
- Prenylcysteine Oxidase 1 Is a Key Regulator of Adipogenesis
Banfi, Antioxidants (Basel, Switzerland) 2023 - “...0.034 1.41 NEG Mitochondrial amidoxime reducing component 2 OS = Mus musculus GN = Marc2 P47738 8 0.016 1.40 NEG Aldehyde dehydrogenase_ mitochondrial OS = Mus musculus GN = Aldh2 Q9D9V3 4 0.022 1.40 NEG Ethylmalonyl-CoA decarboxylase OS = Mus musculus GN = Echdc1 Increased in...”
- Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle
Masania, Redox biology 2023 - “...translation 5. P14602 Heat shock protein beta-1 (HSPB1) 6.44 0.014 Major skeletal muscle chaperone 6. P47738 Aldehyde dehydrogenase, mitochondrial 4.79 0.011 Metabolizes lipid peroxidation products 7. E9PZF0 Nucleoside diphosphate kinase 4.28 0.002 8. P14211 Calreticulin 4.22 0.001 Calcium-binding chaperone 9. Q8VHX6 Filamin-C 3.69 0.005 Sarcomere assembly...”
- ISG15 Is Required for the Dissemination of Vaccinia Virus Extracellular Virions
Bécares, Microbiology spectrum 2023 - “...synthase-coupling factor 6, mitochondrial Atp5pf 1.05 2.80 Q5SUC9 Protein SCO1 homolog, mitochondrial Sco1 1.22 2.22 P47738 Aldehyde dehydrogenase, mitochondrial Aldh2 1.24 3.90 A0A0R4J083 Long-chain specific acyl-CoA dehydrogenase, mitochondrial Acadl 1.37 2.70 Nucleus P15864 Histone H1.2 H1-2 1.84 6.00 Q64525 Histone H2B type 2-B Hist2h2bb 1.64 3.04...”
- Proteomic Analysis of Protective Effects of Dl-3-n-Butylphthalide against mpp + -Induced Toxicity via downregulating P53 pathway in N2A Cells
Zhao, Proteome science 2023 - “...P48678 Lmna Prelamin-A/C 0.001037 P48036 Anxa5 Annexin A5 0.000223 P48025 Syk Tyrosine-protein kinase SYK 0.00388 P47738 Aldh2 \Aldehyde dehydrogenase, mitochondrial \"" 0.00029 P47713 Pla2g4a Cytosolic phospholipase A2 2.33E-05 P46656 Fdx1 \Adrenodoxin, mitochondrial \"" 0.033399 P46414 Cdkn1b Cyclin-dependent kinase inhibitor 1B 0.001209 P45952 Acadm \Medium-chain specific acyl-CoA...”
- Decreased Klotho Expression Causes Accelerated Decline of Male Fecundity through Oxidative Injury in Murine Testis.
Wang, Antioxidants (Basel, Switzerland) 2023 - “...Tpi1 Triosephosphate isomerase 0.679 P17751; P17751-2; H7BXC3 Aldh2 Aldehyde dehydrogenase, mitochondrial 0.610 Q544B1; Q3UJW1; Q3U9J7; P47738; A0A0G2JEU1; Q3U6I3; Q3TVM2 MCODE_4 PPAR signaling pathway Fabp3 Fatty acid-binding protein, heart 2.254 Q5EBJ0; P11404 Me1 Malic enzyme; NADP-dependent malic enzyme 0.703 Q99LF5; Q921S3; P06801; Q3TQP6 Apoa1 Apolipoprotein A-I 0.678...”
- Periostin Protects Against Alcohol-related Liver Disease by Activating Autophagy by Interacting With Protein Disulfide Isomerase.
Zhang, Cellular and molecular gastroenterology and hepatology 2023 - “...Histone H1.3 17 4 1 P46471 Psmc2 26S proteasome regulatory subunit 7 3 1 1 P47738 Aldh2 Aldehyde dehydrogenase mitochondrial 3 1 1 P47753 Capza1 F-actin-capping protein subunit alpha-1 3 1 1 P47754 Capza2 F-actin-capping protein subunit alpha-2 3 1 1 P47963 Rpl13 60S ribosomal protein...”
- Multi-omics analysis reveals the pathogenesis of db/db mice diabetic kidney disease and the treatment mechanisms of multi-bioactive compounds combination from Salvia miltiorrhiza
Xu, Frontiers in pharmacology 2022 - “...mice compared to db/m mice. Salvia miltiorrhiza multi-bioactive compounds combination could callback Q9DBM2, S4R1W1, Q91Y97, P47738, A8DUK4, and A2ARV4. In summary, Salvia miltiorrhiza multi-bioactive compounds combination may ameliorate kidney injury in diabetes through regulation of TGF-/Smad and PI3K/Akt/FoxO signaling pathways. multi-bioactive compounds combination diabetic kidney disease...”
- “...(Peroxisomal bifunctional enzyme), P09411 (Phosphoglycerate kinase 1), P26443 (Glutamate dehydrogenase 1, mitochondrial), S4R1W1 (Glyceraldehyde-3-phosphate dehydrogenase), P47738 (Aldehyde dehydrogenase, mitochondrial), A0A087WS56 (Fibronectin), and P52503 (NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial), which correspond to the genes are Hbb-bs, Lrp2, Aldob, Hba-a1, Ehhadh, Pgk1, Glud1, Gm3839, Aldh2, Fn1,...”
- More
PA4123 5-carboxy-2-hydroxymuconate semialdehyde dehydrogenase from Pseudomonas aeruginosa PAO1
38% identity, 97% coverage
- Designing and Constructing a Novel Artificial Pathway for Malonic Acid Production Biologically
Gu, Frontiers in bioengineering and biotechnology 2021 - “...aspA , and yneI from E. coli ; + panD from Corynebacterium glutamicum ; + pa4123 from Pseudomonas aeruginosa ; ydfG 0.45g/L Fed batch Song et al. (2016) 3.6g/L Shake flask E. coli Acyl-CoA + ehd3 mutant from Saccharomyces cerevisiae 82.3mg/L Shake flask Dietrich et al....”
- Traditional Chinese Medicine Tanreqing Inhibits Quorum Sensing Systems in Pseudomonas aeruginosa
Yang, Frontiers in microbiology 2020 - “...subunit PA4091 hpaA 4.7 4-Hydroxyphenylacetate 3-monooxygenase large chain PA4092 hpaC 4.5 4-Hydroxyphenylacetate 3-monooxygenase small chain PA4123 hpcC 4.2 5-Carboxy-2-hydroxymuconate semialdehyde dehydrogenase PA4124 hpcB 4.0 Homoprotocatechuate 2,3-dioxygenase PA4125 hpcD 4.0 5-Carboxymethyl-2-hydroxymuconate isomerase PA4127 hpcG 3.8 2-Oxo-hept3ene-1,7-dioate hydratase PA5351 rubA1 1.4 Rubredoxin 1 PA4670 prs 1.6 2.0 Ribose-phosphate...”
- Reorganization of gene network for degradation of polycyclic aromatic hydrocarbons (PAHs) in Pseudomonas aeruginosa PAO1 under several conditions
Yan, Journal of applied genetics 2017 - “...PA2513, PA2514, PA2515, PA2516, PA2517, PA2518, PA2546, PA3240, PA3389, PA3629, PA3935, PA4091, PA4092, PA4121, PA4122, PA4123, PA4124, PA4125, PA4190, PA4486, PA4515, and PA5427. Gene network The genes with similar expression profiles are more likely (i) to encode interacting proteins, (ii) to have a similar biological function,...”
- “...aeruginosa PAO1 should increase its synthesis of defending protein. Two PAH degradation genes PA2514 and PA4123 associated with 121 genes at 20min (panel A), among them 28 genes are associated with the transport and metabolism of amino acid or carbohydrate or inorganic ion. At 60min, many...”
Q3UJW1 Aldehyde dehydrogenase, mitochondrial from Mus musculus
39% identity, 90% coverage
PA14_10630 5-carboxy-2-hydroxymuconate semialdehyde dehydrogenase from Pseudomonas aeruginosa UCBPP-PA14
38% identity, 97% coverage
Q3U9J7 Aldehyde dehydrogenase, mitochondrial from Mus musculus
39% identity, 90% coverage
XP_001373128 aldehyde dehydrogenase 1A1 from Monodelphis domestica
39% identity, 91% coverage
Q9KR28 Aldehyde dehydrogenase from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
VC1819 aldehyde dehydrogenase from Vibrio cholerae O1 biovar eltor str. N16961
MS6_1586 aldehyde dehydrogenase family protein from Vibrio cholerae MS6
38% identity, 94% coverage
- Proteomic analysis of Vibrio cholerae in human stool
LaRocque, Infection and immunity 2008 - “...VC1819 VC2073 VCA0002 VCA0455 VCA0809 VCA1028 Q9KRN2 Q9KR28 Q9KQC7 Q9KNG2 Q9KMB8 Q9KLD7 Q56652 a TIGR common name Threonine dehydratase Ubiquinone/menaquinone...”
- Exploration of the effects of a degS mutant on the growth of Vibrio cholerae and the global regulatory function of degS by RNA sequencing
Huang, PeerJ 2019 - “...pathways of differentially expressed genes. Pathway ID Pathway term Pathway gene P -value PATH:00010 Glycolysis/Gluconeogenesis VC1819, VC2000, VC2738,VC2013, VCA0843, VC0485, VC2638 0.0089266 PATH:01200 Carbon metabolism VC2504, VC2000, VC1942, VC2738, VC1304, VC2090, VCA0843, VCA0666, VC0485, VC0432, VC2638, VCA0278, VC2646, VC0027 0.0221534 PATH:00260 Glycine, serine and threonine metabolism...”
- “...PATH:00020 Citrate cycle (TCA cycle) VC2738, VC1304, VC2090, VC0432, VC2638 0.0240401 PATH:01120 Energy metabolism VC2504, VC1819, VC2000, VC2036, VC1942, VC2738, VC0715, VC0384, VC1304, VC2090, VCA0843, VCA0549, VC1347, VC0485, VC0432, VC2638, VCA0278, VC2646, VC2669 0.0257444 PATH:00280 Valine, leucine and isoleucine degradation VCA0007, VC2638, VCA0829 0.0328662 PATH:00620 Pyruvate...”
- Proteomic analysis of Vibrio cholerae in human stool
LaRocque, Infection and immunity 2008 - “...VC1456 Q9KV51 Q9KTS9 Q9KSA5 P01556 VC1457 P01555 VC1604 VC1819 VC2073 VCA0002 VCA0455 VCA0809 VCA1028 Q9KRN2 Q9KR28 Q9KQC7 Q9KNG2 Q9KMB8 Q9KLD7 Q56652 a TIGR...”
- Vibrio cholerae embraces two major evolutionary traits as revealed by targeted gene sequencing
Okada, Scientific reports 2018 - “...mimicus 27 , carried homologues of the aldehyde dehydrogenase (MS6_1585) and sigma 54-dependent transcriptional regulator (MS6_1586) genes between the two loci, although they did not carry M and LH . The alternative selection of M/LH at MS6_A0927 would have occurred in ancestral populations of V. cholerae...”
7a6qA / P47895 Crystal structure of human aldehyde dehydrogenase 1a3 in complex with selective nr6 inhibitor compound (see paper)
37% identity, 96% coverage
- Ligands: nicotinamide-adenine-dinucleotide; 3-(2-phenylimidazo[1,2-a]pyridin-6-yl)benzenecarbonitrile (7a6qA)
Q6TH48 Aldehyde dehydrogenase, mitochondrial from Danio rerio
39% identity, 91% coverage
- Comparative genomics, molecular evolution and computational modeling of ALDH1B1 and ALDH2
Jackson, Chemico-biological interactions 2013 - “...13 (ve) 24,853 56,563 na 117 75 68 64 Zebrafish Danio rerio 2b NM_213301 AY398308 Q6TH48 516 5:72,465,28272,486,769 13 (ve) 21,488 56,550 na 117 75 68 64 Zebrafish Danio rerio 2c CAM13323 BX510999 Q7SXU3 516 5:72,441,57672,461,572 13 (ve) 19,997 56,483 na 118 76 69 65 na:...”
- Molecular phenotype of zebrafish ovarian follicle by serial analysis of gene expression and proteomic profiling, and comparison with the transcriptomes of other animals
Knoll-Gellida, BMC genomics 2006 - “...dismutase [Cu-Zn] O73872 22 CATGTCTGAGCTGA 4 AY398308 Dr.4751 aldh2 Mitochondrial aldehyde dehydrogenase 2 family [aldh2l] Q6TH48, Q6NWJ9 10, 11 CATGAACCACTCAA 4 BC050953 Dr.7644 cct2 Chaperonin containing TCP1, subunit 2 (Beta) Q6PBW6 V CATGACACAAAATA 4 BQ263267 Dr.25009 vg1 Vitellogenin 1 Q8JH36, Q8JH37, Q90YN8 I-XI, 17, 1017, 2124...”
HD73_0368 NADP-dependent succinate-semialdehyde dehydrogenase from Bacillus thuringiensis serovar kurstaki str. HD73
34% identity, 98% coverage
- Identification of metabolism pathways directly regulated by sigma(54) factor in Bacillus thuringiensis
Peng, Frontiers in microbiology 2015 - “...Annotation Fold-change HD73_0366 4-aminobutyrate aminotransferase 9.165 HD73_0367 Sensory box sigma-54 dependent DNA-binding response regulator 2.860 HD73_0368 Succinic semialdehyde dehydrogenase 2.410 HD73_0369 Quaternary ammonium compound-resistance protein 2.377 HD73_0560 Biotin carboxyl carrier protein - HD73_0561 Hypothetical protein - HD73_0562 Amino-acid permease rocC - HD73_1024 Proline racemase 62.621 HD73_1025...”
BAA13145 / Q47943 L-sorbosone dehydrogenase subunit from Gluconobacter oxydans (see paper)
37% identity, 95% coverage
T1FVK5 Aldehyde dehydrogenase domain-containing protein from Helobdella robusta
37% identity, 91% coverage
I3LRS5 aldehyde dehydrogenase (NAD(+)) from Sus scrofa
38% identity, 94% coverage
- Animal Food Products to Support Human Nutrition and to Boost Human Health: The Potential of Feedstuffs Resources and Their Metabolites as Health-Promoters.
Cuchillo-Hilario, Metabolites 2024 - “...the porcine liver as pigments and bioactive peptides and evaluated two isoforms of aldehyde dehydrogenase (I3LRS5, ALDH1A1) and four peptides from fructose bisphosphate aldolase (A0A4X1VHB8, ALDOB) as correlated with antioxidant and antihypertensive elements. Mora et al. [ 133 ] reported that Iberian dry-cured ham is a...”
- “...0.31 mg/mL for S. aureus . Abou-Diab et al., 2020 [ 137 ] Bioactive peptides I3LRS5, ALDH1A1, A0A4X1VHB8, and ALDOB Porcine liver protein fraction at pH 4.8 showed antioxidant capacity but antihypertensive inhibition NR Two isoforms of aldehyde dehydrogenase (I3LRS5, ALDH1A1) and four peptides from fructose...”
- Label-free quantitative proteomics and stress responses in pigs-The case of short or long road transportation
Di, PloS one 2022 - “...2 4.87 0.008 3.1 STRESSED A0A287AGG3 PSMB5 Proteasome subunit beta 2 6.71 0.021 3.05 STRESSED I3LRS5 ALDH1A1 Aldehyde dehydrogenase 1 family member A1 2 5.61 0.012 2.73 STRESSED A0A287AT21 SORD Sorbitol dehydrogenase 2 9.86 0.014 2.61 STRESSED I3L9I6 BCAM Basal cell adhesion molecule (Lutheran blood group)...”
- Diffusion and Protein Corona Formation of Lipid-Based Nanoparticles in the Vitreous Humor: Profiling and Pharmacokinetic Considerations
Tavakoli, Molecular pharmaceutics 2021 - “...(+) 0.582 AL2 (0.51:0.46) A0A287ARU7 YWHAE 1433 protein g 27.4 4.77 () 0.440 AL2 (0.51:0.49) I3LRS5 ALDH1A1 retinal dehydrogenase 1 22.9 6.44 () 0.085 AL1-PEG (0.65:0.23) A0A287BCX5 ATP6V1A V-type proton ATPase catalytic subunit A g 64.2 5.38 () 0.165 AL1-PEG (0.51:0.41) A0A287AYJ0 DPYSL3 dihydropyrimidinase-related protein 3...”
- Sperm Proteome after Interaction with Reproductive Fluids in Porcine: From the Ejaculation to the Fertilization Site
Luongo, International journal of molecular sciences 2020 - “...ribosomal protein P2 A0A287B7U0 60S ribosomal protein L4 A0A5G2QSX6 Aldehyde dehydrogenase 1 family member A1 I3LRS5 Annexin I F1SJB5 Annexin II A0A286ZJV6 Annexin V F2Z5C1 Calreticulin P28491 Clathrin light chain A0A287BFJ2 Cofilin-1 K7GK75 Deleted in malignant brain tumors 1 protein Q4A3R3 Endoplasmic reticulum chaperone BiP/78 kDa...”
- Proteomic analysis indicates that mitochondrial energy metabolism in skeletal muscle tissue is negatively correlated with feed efficiency in pigs.
Fu, Scientific reports 2017 - “...1.44 0.02 F1RX51 malignant T-cell-amplified sequence Ssc.3881 1.48 0.001 I3L8S3 carboxymethylenebutenolidase homolog CMBL 1.5 0.01 I3LRS5 aldehyde dehydrogenase 1 family member A1 ALDH1A1 1.5 0.03 F1S288 syntrophin beta 1 SNTB1 1.57 0.04 Q2PYM7 proteasome subunit beta 9 LMP2 1.85 0.04 Q3ZD69 lamin A/C LMNA 1.92 0.002...”
ALDH1A3 / P47895 retinal dehydrogenase 3 (EC 1.2.1.36) from Homo sapiens (see 3 papers)
AL1A3_HUMAN / P47895 Retinaldehyde dehydrogenase 3; RALDH-3; RalDH3; Aldehyde dehydrogenase 6; Aldehyde dehydrogenase family 1 member A3; ALDH1A3; EC 1.2.1.36 from Homo sapiens (Human) (see 9 papers)
P47895 retinal dehydrogenase (EC 1.2.1.36); aldehyde dehydrogenase [NAD(P)+] (EC 1.2.1.5) from Homo sapiens (see 6 papers)
NP_000684 retinaldehyde dehydrogenase 3 isoform 1 from Homo sapiens
37% identity, 92% coverage
- function: Catalyzes the NAD-dependent oxidation of aldehyde substrates, such as all-trans-retinal and all-trans-13,14-dihydroretinal, to their corresponding carboxylic acids, all-trans-retinoate and all-trans- 13,14-dihydroretinoate, respectively (By similarity) (PubMed:27759097). High specificity for all-trans-retinal as substrate, can also accept acetaldehyde as substrate in vitro but with lower affinity (PubMed:27759097). Required for the biosynthesis of normal levels of retinoate in the embryonic ocular and nasal regions; a critical lipid in the embryonic development of the eye and the nasal region (By similarity).
catalytic activity: all-trans-retinal + H2O + NAD(+) = all-trans-retinoate + 2 H(+) + NADH (RHEA:42080)
catalytic activity: H2O + NAD(+) + retinal = 2 H(+) + NADH + retinoate (RHEA:16177)
catalytic activity: all-trans-13,14-dihydroretinal + H2O + NAD(+) = all-trans- 13,14-dihydroretinoate + 2 H(+) + NADH (RHEA:75119)
subunit: Homotetramer. - METTL3-mediated ALDH m6A methylation regulates the malignant behavior of BMI1+ HNSCC stem cells.
Chen, Oral diseases 2024 (PubMed)- GeneRIF: METTL3-mediated ALDH m[6]A methylation regulates the malignant behavior of BMI1[+] HNSCC stem cells.
- ALDH1A3 promotes invasion and metastasis in triple-negative breast cancer by regulating the plasminogen activation pathway.
Bharadwaj, Molecular oncology 2024 - GeneRIF: ALDH1A3 promotes invasion and metastasis in triple-negative breast cancer by regulating the plasminogen activation pathway.
- ALDH1A3 is the switch that determines the balance of ALDH+ and CD24-CD44+ cancer stem cells, EMT-MET, and glucose metabolism in breast cancer.
Fernando, Oncogene 2024 - GeneRIF: ALDH1A3 is the switch that determines the balance of ALDH[+] and CD24[-]CD44[+] cancer stem cells, EMT-MET, and glucose metabolism in breast cancer.
- MiR-320b aberrant expression enhances the radioresistance of human glioma via upregulated expression of ALDH1A3.
Mao, Aging 2023 - GeneRIF: MiR-320b aberrant expression enhances the radioresistance of human glioma via upregulated expression of ALDH1A3.
- Clinical and genetic analysis further delineates the phenotypic spectrum of ALDH1A3-related anophthalmia and microphthalmia.
Kesim, European journal of human genetics : EJHG 2023 - GeneRIF: Clinical and genetic analysis further delineates the phenotypic spectrum of ALDH1A3-related anophthalmia and microphthalmia.
- Enhanced Sensitivity to ALDH1A3-Dependent Ferroptosis in TMZ-Resistant Glioblastoma Cells.
Wu, Cells 2023 - GeneRIF: Enhanced Sensitivity to ALDH1A3-Dependent Ferroptosis in TMZ-Resistant Glioblastoma Cells.
- Structural and biochemical evidence that ATP inhibits the cancer biomarker human aldehyde dehydrogenase 1A3.
Castellví, Communications biology 2022 - GeneRIF: Structural and biochemical evidence that ATP inhibits the cancer biomarker human aldehyde dehydrogenase 1A3.
- Lactic acidosis promotes aggressive features of cholangiocarcinoma cells via upregulating ALDH1A3 expression through EGFR axis.
Thamrongwaranggoon, Life sciences 2022 (PubMed)- GeneRIF: Lactic acidosis promotes aggressive features of cholangiocarcinoma cells via upregulating ALDH1A3 expression through EGFR axis.
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- ALDH1A3-acetaldehyde metabolism potentiates transcriptional heterogeneity in melanoma.
Lu, Cell reports 2024 - “...sequences of yeast ALD6 (UniProt: P54115 ) and ACS2 (UniProt: P52910) and human ALDH1A3 (UniProt: P47895) and ACSS2 (UniProt: Q9NR19) were retrieved. 121 Disordered N-termini of the human proteins, the first 24 residues of each, were removed to facilitate complex prediction. AlphaFold-Multimer 76 predictions were performed...”
- Characterization of human oxidoreductases involved in aldehyde odorant metabolism.
Boichot, Scientific reports 2023 - “...1) Dihydropteridine reductase P09417 7 (8, 7, 0) Aldehyde dehydrogenase family 1 member A3 (ALDH1A3) P47895 10 (5, 9, 0) Carbonyl reductase [NADPH] 3 O75828 8 (5, 5, 0) 25-Hydroxycholesterol 7-alpha-hydroxylase O75881 4 (3, 7, 0) Aflatoxin B1 aldehyde reductase member 2 (AKR7A2) O43488 6 (3,...”
- LHPP Inhibits the Viability, Migration, and Proliferation of PDAC Cells and Significantly Affects the Expression of SDC1 and S100p.
Xia, Technology in cancer research & treatment 2023 - “...2.131E-03 0.624 1.319E-02 P23229 ITGA6 0.452 3.015E-06 0.988 5.703E-01 P25815 S100P 0.990 7.654E-01 0.661 4.669E-04 P47895 ALDH1A3 0.360 8.545E-08 1.132 1.747E-03 P78504 JAG1 1.008 7.458E-01 1.848 1.091E-05 Q00534 CDK6 0.769 4.082E-04 1.382 9.703E-05 Q14258 TRIM25 0.722 1.178E-03 0.650 4.520E-04 Q6PIU2 NCEH1 0.869 2.592E-04 0.575 1.116E-05 Q96LJ7...”
- Zika Virus Infection of Sertoli Cells Alters Protein Expression Involved in Activated Immune and Antiviral Response Pathways, Carbohydrate Metabolism and Cardiovascular Disease
Rashid, Viruses 2022 - “...2.1 10 4 Q96LM1 LINC00615 Putative uncharacterized protein encoded by LINC00615 2.56 3.0 10 3 P47895 ALDH1A3 Aldehyde dehydrogenase family 1 member A3 2.50 3.4 10 5 3.86 9.7 10 5 1.38 2.9 10 2 P20592 MX2 Interferon-induced GTP-binding protein Mx2 2.48 9.3 10 5 2.98...”
- Quantitative proteomic analysis of aberrant expressed lysine acetylation in gastrointestinal stromal tumors
Wang, Clinical proteomics 2021 - “...P47756 F-actin-capping protein subunit beta OS=Homo sapiens OX=9606 GN=CAPZB PE=1 SV=4 235 1.399 Up 0.022458 P47895 Aldehyde dehydrogenase family 1 member A3 OS=Homo sapiens OX=9606 GN=ALDH1A3 PE=1 SV=2 373 2.773 Up 0.0454 P48163 NADP-dependent malic enzyme OS=Homo sapiens OX=9606 GN=ME1 PE=1 SV=1 60 0.731 Down 0.02706...”
- CD9 inhibition reveals a functional connection of extracellular vesicle secretion with mitophagy in melanoma cells
Suárez, Journal of extracellular vesicles 2021 - “...P50990 23 0.63 Tcomplex protein 1 subunit theta OS=Homo sapiens OX=9606 GN=CCT8 PE=1 SV=4 ALDH1A3 P47895 21.75 0.63 Aldehyde dehydrogenase family 1 member A3 OS=Homo sapiens OX=9606 GN=ALDH1A3 PE=1 SV=2 RGN Q15493 40.54 0.64 Regucalcin OS=Homo sapiens OX=9606 GN=RGN PE=1 SV=1 F13A1 P00488 30.72 0.64 Coagulation...”
- Proteomic Analysis of Tears and Conjunctival Cells Collected with Schirmer Strips Using timsTOF Pro: Preanalytical Considerations
Akkurt, Metabolites 2021 - “...2.1 22 1 P07858 Cathepsin B [ 1 ] 18.3 1.5 19.7 1.5 22 1.7 P47895 Aldehyde dehydrogenase family 1 member A3 [ 23 , 48 ] 18 2.6 23.7 1.5 6.3 2.1 P00738 Haptoglobin [ 1 ] 18 2 19 1.7 14 0 P30740 Serpin...”
- Mass Spectrometry and Computer Simulation Predict the Interactions of AGPS and HNRNPK in Glioma.
Zhou, BioMed research international 2021 - “...P04350 Tubulin beta-4A chain TUBB4A 1767.33 56 O94925 Glutaminase kidney isoform, mitochondrial GLS 70.06 21 P47895 Aldehyde dehydrogenase family 1 member A3 ALDH1A3 1583.06 57 Q15392 Delta(24)-sterol reductase DHCR24 69.37 22 Q07065 Cytoskeleton-associated protein 4 CKAP4 1229.76 58 Q9NRG9 Aladin AAAS 65.81 23 Q13885 Tubulin beta-2A...”
- More
BC1G_06362 hypothetical protein from Botrytis cinerea B05.10
37% identity, 95% coverage
Q2F5Y9 Mitochondrial aldehyde dehydrogenase from Bombyx mori
38% identity, 97% coverage
- Investigation of the protein profile of silkworm (Bombyx mori) pupae reared on a well-calibrated artificial diet compared to mulberry leaf diet
Lamberti, PeerJ 2019 - “...Vitellogenin 203,725/40,000 6.85/6.00 16 1,087 10.5 126 H9IXK0 Antichymotrypsin-1 41,893/45,000 5.14/5.10 29 2,062 57.6 135 Q2F5Y9 Mitochondrial aldehyde dehydrogenase 53,127/54,000 5.57/5.70 14 696 31.1 141 P49010 Chitooligosaccharidolytic beta- N -acetylglucosaminidase 68,968/60,000 5.17/5.70 24 1,871 39.3 H9J8Q7 Beta-hexosaminidase 61,914/60,000 5.33/5.30 24 1,836 44.5 144 Q1HPP4 Arylphorin 83,569/80,000...”
ACIAD1009 NAD+-dependent betaine aldehyde dehydrogenase from Acinetobacter sp. ADP1
36% identity, 97% coverage
- Characterization of a novel β-alanine biosynthetic pathway consisting of promiscuous metabolic enzymes
Perchat, The Journal of biological chemistry 2022 - “...showed that four proteins exhibited activity ( Table1 ). Based on these data, ACIAD0960 (GabD-like), ACIAD1009 (BetB), ACIAD2018 (acoD), and ACIAD3339 (AdhA) were purified (see the Experimental procedures section and Fig.S2 ) and kinetically characterized ( Table2 ). ACoD and AdhA were specific for NAD +...”
- “...1 ) ACIAD0960 gabD like Putative succinate-semialdehyde dehydrogenase [NADP + ] (GabD-like) 5.47 0.08 a ACIAD1009 betB NAD + -dependent betaine aldehyde dehydrogenase 1.80 0.02 b ACIAD2018 acoD Acetaldehyde dehydrogenase II (ACDH-II) 5.71 0.06 b ACIAD3339 adhA Alcohol dehydrogenase 1.99 0.03 b Activities reported represent the...”
I1U3B9 Aldehyde dehydrogenase 1 family member L1 (Fragment) from Ovis aries
40% identity, 81% coverage
7w5nA / Q47943 The crystal structure of the reduced form of gluconobacter oxydans wsh-004 sndh (see paper)
37% identity, 97% coverage
- Ligand: nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (7w5nA)
DW66_3578 aldehyde dehydrogenase family protein from Pseudomonas putida
37% identity, 91% coverage
- The Regulation of para-Nitrophenol Degradation in Pseudomonas putida DLL-E4
Chen, PloS one 2016 - “...1,4-benzoquinone reductase 306.1 47.6 610.8 298.2 6.9 17.7 DW66_3577 pnpE maleylacetate reductase 32.3 12.7 0.4 DW66_3578 pnpD 4-hydroxymuconic semial-dehydrogenase 23.2 12.7 0.6 DW66_3579 pnpC2 hydroquinone hydroxylase beta subunit 35.4 30.7 0.5 DW66_3580 pnpC1 hydroquinone dioxygenase alpha subunit 25.7 10.3 21.6 17.2 0.4 0.6 DW66_3581 pnpR putative...”
NP_776664 aldehyde dehydrogenase 1A1 from Bos taurus
39% identity, 94% coverage
U3IF86 Aldehyde dehydrogenase from Anas platyrhynchos platyrhynchos
38% identity, 92% coverage
For advice on how to use these tools together, see
Interactive tools for functional annotation of bacterial genomes.
The PaperBLAST database links 784,739 different protein sequences to 1,253,012 scientific articles. Searches against EuropePMC were last performed on November 25 2024.
PaperBLAST builds a database of protein sequences that are linked
to scientific articles. These links come from automated text searches
against the articles in EuropePMC
and from manually-curated information from GeneRIF, UniProtKB/Swiss-Prot,
BRENDA,
CAZy (as made available by dbCAN),
BioLiP,
CharProtDB,
MetaCyc,
EcoCyc,
TCDB,
REBASE,
the Fitness Browser,
and a subset of the European Nucleotide Archive with the /experiment tag.
Given this database and a protein sequence query,
PaperBLAST uses protein-protein BLAST
to find similar sequences with E < 0.001.
To build the database, we query EuropePMC with locus tags, with RefSeq protein
identifiers, and with UniProt
accessions. We obtain the locus tags from RefSeq or from MicrobesOnline. We use
queries of the form "locus_tag AND genus_name" to try to ensure that
the paper is actually discussing that gene. Because EuropePMC indexes
most recent biomedical papers, even if they are not open access, some
of the links may be to papers that you cannot read or that our
computers cannot read. We query each of these identifiers that
appears in the open access part of EuropePMC, as well as every locus
tag that appears in the 500 most-referenced genomes, so that a gene
may appear in the PaperBLAST results even though none of the papers
that mention it are open access. We also incorporate text-mined links
from EuropePMC that link open access articles to UniProt or RefSeq
identifiers. (This yields some additional links because EuropePMC
uses different heuristics for their text mining than we do.)
For every article that mentions a locus tag, a RefSeq protein
identifier, or a UniProt accession, we try to select one or two
snippets of text that refer to the protein. If we cannot get access to
the full text, we try to select a snippet from the abstract, but
unfortunately, unique identifiers such as locus tags are rarely
provided in abstracts.
PaperBLAST also incorporates manually-curated protein functions:
- Proteins from NCBI's RefSeq are included if a
GeneRIF
entry links the gene to an article in
PubMed®.
GeneRIF also provides a short summary of the article's claim about the
protein, which is shown instead of a snippet.
- Proteins from Swiss-Prot (the curated part of UniProt)
are included if the curators
identified experimental evidence for the protein's function (evidence
code ECO:0000269). For these proteins, the fields of the Swiss-Prot entry that
describe the protein's function are shown (with bold headings).
- Proteins from BRENDA,
a curated database of enzymes, are included if they are linked to a paper in PubMed
and their full sequence is known.
- Every protein from the non-redundant subset of
BioLiP,
a database
of ligand-binding sites and catalytic residues in protein structures, is included. Since BioLiP itself
does not include descriptions of the proteins, those are taken from the
Protein Data Bank.
Descriptions from PDB rely on the original submitter of the
structure and cannot be updated by others, so they may be less reliable.
(For SitesBLAST and Sites on a Tree, we use a larger subset of BioLiP so that every
ligand is represented among a group of structures with similar sequences, but for
PaperBLAST, we use the non-redundant set provided by BioLiP.)
- Every protein from EcoCyc, a curated
database of the proteins in Escherichia coli K-12, is included, regardless
of whether they are characterized or not.
- Proteins from the MetaCyc metabolic pathway database
are included if they are linked to a paper in PubMed and their full sequence is known.
- Proteins from the Transport Classification Database (TCDB)
are included if they have known substrate(s), have reference(s),
and are not described as uncharacterized or putative.
(Some of the references are not visible on the PaperBLAST web site.)
- Every protein from CharProtDB,
a database of experimentally characterized protein annotations, is included.
- Proteins from the CAZy database of carbohydrate-active enzymes
are included if they are associated with an Enzyme Classification number.
Even though CAZy does not provide links from individual protein sequences to papers,
these should all be experimentally-characterized proteins.
- Proteins from the REBASE database
of restriction enzymes are included if they have known specificity.
- Every protein with an evidence-based reannotation (based on mutant phenotypes)
in the Fitness Browser is included.
- Sequence-specific transcription factors (including sigma factors and DNA-binding response regulators)
with experimentally-determined DNA binding sites from the
PRODORIC database of gene regulation in prokaryotes.
- Putative transcription factors from RegPrecise
that have manually-curated predictions for their binding sites. These predictions are based on
conserved putative regulatory sites across genomes that contain similar transcription factors,
so PaperBLAST clusters the TFs at 70% identity and retains just one member of each cluster.
- Coding sequence (CDS) features from the
European Nucleotide Archive (ENA)
are included if the /experiment tag is set (implying that there is experimental evidence for the annotation),
the nucleotide entry links to paper(s) in PubMed,
and the nucleotide entry is from the STD data class
(implying that these are targeted annotated sequences, not from shotgun sequencing).
Also, to filter out genes whose transcription or translation was detected, but whose function
was not studied, nucleotide entries or papers with more than 25 such proteins are excluded.
Descriptions from ENA rely on the original submitter of the
sequence and cannot be updated by others, so they may be less reliable.
Except for GeneRIF and ENA,
the curated entries include a short curated
description of the protein's function.
For entries from BioLiP, the protein's function may not be known beyond binding to the ligand.
Many of these entries also link to articles in PubMed.
For more information see the
PaperBLAST paper (mSystems 2017)
or the code.
You can download PaperBLAST's database here.
Changes to PaperBLAST since the paper was written:
- November 2023: incorporated PRODORIC and RegPrecise. Many PRODORIC entries were not linked to a protein sequence (no UniProt identifier), so we added this information.
- February 2023: BioLiP changed their download format. PaperBLAST now includes their non-redundant subset. SitesBLAST and Sites on a Tree use a larger non-redundant subset that ensures that every ligand is represented within each cluster. This should ensure that every binding site is represented.
- June 2022: incorporated some coding sequences from ENA with the /experiment tag.
- March 2022: incorporated BioLiP.
- April 2020: incorporated TCDB.
- April 2019: EuropePMC now returns table entries in their search results. This has expanded PaperBLAST's database, but most of the new entries are of low relevance, and the resulting snippets are often just lists of locus tags with annotations.
- February 2018: the alignment page reports the conservation of the hit's functional sites (if available from from Swiss-Prot or UniProt)
- January 2018: incorporated BRENDA.
- December 2017: incorporated MetaCyc, CharProtDB, CAZy, REBASE, and the reannotations from the Fitness Browser.
- September 2017: EuropePMC no longer returns some table entries in their search results. This has shrunk PaperBLAST's database, but has also reduced the number of low-relevance hits.
Many of these changes are described in Interactive tools for functional annotation of bacterial genomes.
PaperBLAST cannot provide snippets for many of the papers that are
published in non-open-access journals. This limitation applies even if
the paper is marked as "free" on the publisher's web site and is
available in PubmedCentral or EuropePMC. If a journal that you publish
in is marked as "secret," please consider publishing elsewhere.
Many important articles are missing from PaperBLAST, either because
the article's full text is not in EuropePMC (as for many older
articles), or because the paper does not mention a protein identifier such as a locus tag, or because of PaperBLAST's heuristics. If you notice an
article that characterizes a protein's function but is missing from
PaperBLAST, please notify the curators at UniProt
or add an entry to GeneRIF.
Entries in either of these databases will eventually be incorporated
into PaperBLAST. Note that to add an entry to UniProt, you will need
to find the UniProt identifier for the protein. If the protein is not
already in UniProt, you can ask them to create an entry. To add an
entry to GeneRIF, you will need an NCBI Gene identifier, but
unfortunately many prokaryotic proteins in RefSeq do not have
corresponding Gene identifers.
References
PaperBLAST: Text-mining papers for information about homologs.
M. N. Price and A. P. Arkin (2017). mSystems, 10.1128/mSystems.00039-17.
Europe PMC in 2017.
M. Levchenko et al (2017). Nucleic Acids Research, 10.1093/nar/gkx1005.
Gene indexing: characterization and analysis of NLM's GeneRIFs.
J. A. Mitchell et al (2003). AMIA Annu Symp Proc 2003:460-464.
UniProt: the universal protein knowledgebase.
The UniProt Consortium (2016). Nucleic Acids Research, 10.1093/nar/gkw1099.
BRENDA in 2017: new perspectives and new tools in BRENDA.
S. Placzek et al (2017). Nucleic Acids Research, 10.1093/nar/gkw952.
The EcoCyc database: reflecting new knowledge about Escherichia coli K-12.
I. M. Keeseler et al (2016). Nucleic Acids Research, 10.1093/nar/gkw1003.
The MetaCyc database of metabolic pathways and enzymes.
R. Caspi et al (2018). Nucleic Acids Research, 10.1093/nar/gkx935.
CharProtDB: a database of experimentally characterized protein annotations.
R. Madupu et al (2012). Nucleic Acids Research, 10.1093/nar/gkr1133.
The carbohydrate-active enzymes database (CAZy) in 2013.
V. Lombard et al (2014). Nucleic Acids Research, 10.1093/nar/gkt1178.
The Transporter Classification Database (TCDB): recent advances
M. H. Saier, Jr. et al (2016). Nucleic Acids Research, 10.1093/nar/gkv1103.
REBASE - a database for DNA restriction and modification: enzymes, genes and genomes.
R. J. Roberts et al (2015). Nucleic Acids Research, 10.1093/nar/gku1046.
Deep annotation of protein function across diverse bacteria from mutant phenotypes.
M. N. Price et al (2016). bioRxiv, 10.1101/072470.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory