queryId subjectDb subjectId identity queryAlnBegin queryAlnEnd sujectAlnBegin subjectAlnEnd subjectDescription evalue bits subjectSite subjectSiteRange subjectSiteSeq querySiteRange querySiteSeq pubMedIds 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2vr1:A 63.2 4 446 2 442 Crystal structure of biotin carboxylase from e. Coli in complex with atp analog, adpcf2p. 1e-169 591 active site 116 K 118 K 18725455 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2vr1:A 63.2 4 446 2 442 Crystal structure of biotin carboxylase from e. Coli in complex with atp analog, adpcf2p. 1e-169 591 active site 159 K 161 K 18725455 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2vr1:A 63.2 4 446 2 442 Crystal structure of biotin carboxylase from e. Coli in complex with atp analog, adpcf2p. 1e-169 591 active site 194 D 198 G 18725455 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2vr1:A 63.2 4 446 2 442 Crystal structure of biotin carboxylase from e. Coli in complex with atp analog, adpcf2p. 1e-169 591 active site 207 H 211 H 18725455 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2vr1:A 63.2 4 446 2 442 Crystal structure of biotin carboxylase from e. Coli in complex with atp analog, adpcf2p. 1e-169 591 active site 233 R 237 A 18725455 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2vr1:A 63.2 4 446 2 442 Crystal structure of biotin carboxylase from e. Coli in complex with atp analog, adpcf2p. 1e-169 591 active site 272 T 276 T 18725455 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2vr1:A 63.2 4 446 2 442 Crystal structure of biotin carboxylase from e. Coli in complex with atp analog, adpcf2p. 1e-169 591 active site 274 E 278 E 18725455 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2vr1:A 63.2 4 446 2 442 Crystal structure of biotin carboxylase from e. Coli in complex with atp analog, adpcf2p. 1e-169 591 active site 286 E 290 E 18725455 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2vr1:A 63.2 4 446 2 442 Crystal structure of biotin carboxylase from e. Coli in complex with atp analog, adpcf2p. 1e-169 591 active site 288 N 292 N 18725455 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2vr1:A 63.2 4 446 2 442 Crystal structure of biotin carboxylase from e. Coli in complex with atp analog, adpcf2p. 1e-169 591 active site 290 R 294 R 18725455 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2vr1:A 63.2 4 446 2 442 Crystal structure of biotin carboxylase from e. Coli in complex with atp analog, adpcf2p. 1e-169 591 active site 294 E 298 E 18725455 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2vr1:A 63.2 4 446 2 442 Crystal structure of biotin carboxylase from e. Coli in complex with atp analog, adpcf2p. 1e-169 591 active site 336 R 340 R 18725455 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2vr1:A 63.2 4 446 2 442 Crystal structure of biotin carboxylase from e. Coli in complex with atp analog, adpcf2p. 1e-169 591 binding phosphodifluoromethylphosphonic acid-adenylate ester 159 K 161 K 18725455 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2vr1:A 63.2 4 446 2 442 Crystal structure of biotin carboxylase from e. Coli in complex with atp analog, adpcf2p. 1e-169 591 binding phosphodifluoromethylphosphonic acid-adenylate ester 165 R 169 K 18725455 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2vr1:A 63.2 4 446 2 442 Crystal structure of biotin carboxylase from e. Coli in complex with atp analog, adpcf2p. 1e-169 591 binding phosphodifluoromethylphosphonic acid-adenylate ester 167 M 171 M 18725455 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2vr1:A 63.2 4 446 2 442 Crystal structure of biotin carboxylase from e. Coli in complex with atp analog, adpcf2p. 1e-169 591 binding phosphodifluoromethylphosphonic acid-adenylate ester 201 Y 205 Y 18725455 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2vr1:A 63.2 4 446 2 442 Crystal structure of biotin carboxylase from e. Coli in complex with atp analog, adpcf2p. 1e-169 591 binding phosphodifluoromethylphosphonic acid-adenylate ester 202 L 206 L 18725455 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2vr1:A 63.2 4 446 2 442 Crystal structure of biotin carboxylase from e. Coli in complex with atp analog, adpcf2p. 1e-169 591 binding phosphodifluoromethylphosphonic acid-adenylate ester 274 E 278 E 18725455 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2vr1:A 63.2 4 446 2 442 Crystal structure of biotin carboxylase from e. Coli in complex with atp analog, adpcf2p. 1e-169 591 binding phosphodifluoromethylphosphonic acid-adenylate ester 276 L 280 L 18725455 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2vr1:A 63.2 4 446 2 442 Crystal structure of biotin carboxylase from e. Coli in complex with atp analog, adpcf2p. 1e-169 591 binding phosphodifluoromethylphosphonic acid-adenylate ester 286 E 290 E 18725455 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2vr1:A 63.2 4 446 2 442 Crystal structure of biotin carboxylase from e. Coli in complex with atp analog, adpcf2p. 1e-169 591 binding phosphodifluoromethylphosphonic acid-adenylate ester 288 N 292 N 18725455 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2vr1:A 63.2 4 446 2 442 Crystal structure of biotin carboxylase from e. Coli in complex with atp analog, adpcf2p. 1e-169 591 binding phosphodifluoromethylphosphonic acid-adenylate ester 435 I 439 I 18725455 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 4mv4:A 62.3 4 446 2 441 Crystal structure of biotin carboxylase from haemophilus influenzae in complex with amppcp and mg2 1e-166 582 active site 116 K 118 K 26020841 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 4mv4:A 62.3 4 446 2 441 Crystal structure of biotin carboxylase from haemophilus influenzae in complex with amppcp and mg2 1e-166 582 active site 159 K 161 K 26020841 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 4mv4:A 62.3 4 446 2 441 Crystal structure of biotin carboxylase from haemophilus influenzae in complex with amppcp and mg2 1e-166 582 active site 193 D 198 G 26020841 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 4mv4:A 62.3 4 446 2 441 Crystal structure of biotin carboxylase from haemophilus influenzae in complex with amppcp and mg2 1e-166 582 active site 206 H 211 H 26020841 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 4mv4:A 62.3 4 446 2 441 Crystal structure of biotin carboxylase from haemophilus influenzae in complex with amppcp and mg2 1e-166 582 active site 232 R 237 A 26020841 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 4mv4:A 62.3 4 446 2 441 Crystal structure of biotin carboxylase from haemophilus influenzae in complex with amppcp and mg2 1e-166 582 active site 271 T 276 T 26020841 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 4mv4:A 62.3 4 446 2 441 Crystal structure of biotin carboxylase from haemophilus influenzae in complex with amppcp and mg2 1e-166 582 active site 273 E 278 E 26020841 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 4mv4:A 62.3 4 446 2 441 Crystal structure of biotin carboxylase from haemophilus influenzae in complex with amppcp and mg2 1e-166 582 active site 285 E 290 E 26020841 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 4mv4:A 62.3 4 446 2 441 Crystal structure of biotin carboxylase from haemophilus influenzae in complex with amppcp and mg2 1e-166 582 active site 287 N 292 N 26020841 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 4mv4:A 62.3 4 446 2 441 Crystal structure of biotin carboxylase from haemophilus influenzae in complex with amppcp and mg2 1e-166 582 active site 289 R 294 R 26020841 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 4mv4:A 62.3 4 446 2 441 Crystal structure of biotin carboxylase from haemophilus influenzae in complex with amppcp and mg2 1e-166 582 active site 293 E 298 E 26020841 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 4mv4:A 62.3 4 446 2 441 Crystal structure of biotin carboxylase from haemophilus influenzae in complex with amppcp and mg2 1e-166 582 active site 335 R 340 R 26020841 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 4mv4:A 62.3 4 446 2 441 Crystal structure of biotin carboxylase from haemophilus influenzae in complex with amppcp and mg2 1e-166 582 binding phosphomethylphosphonic acid adenylate ester 159 K 161 K 26020841 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 4mv4:A 62.3 4 446 2 441 Crystal structure of biotin carboxylase from haemophilus influenzae in complex with amppcp and mg2 1e-166 582 binding phosphomethylphosphonic acid adenylate ester 164 G 166 G 26020841 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 4mv4:A 62.3 4 446 2 441 Crystal structure of biotin carboxylase from haemophilus influenzae in complex with amppcp and mg2 1e-166 582 binding phosphomethylphosphonic acid adenylate ester 166 M 171 M 26020841 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 4mv4:A 62.3 4 446 2 441 Crystal structure of biotin carboxylase from haemophilus influenzae in complex with amppcp and mg2 1e-166 582 binding phosphomethylphosphonic acid adenylate ester 198 E 203 E 26020841 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 4mv4:A 62.3 4 446 2 441 Crystal structure of biotin carboxylase from haemophilus influenzae in complex with amppcp and mg2 1e-166 582 binding phosphomethylphosphonic acid adenylate ester 200 Y 205 Y 26020841 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 4mv4:A 62.3 4 446 2 441 Crystal structure of biotin carboxylase from haemophilus influenzae in complex with amppcp and mg2 1e-166 582 binding phosphomethylphosphonic acid adenylate ester 201 L 206 L 26020841 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 4mv4:A 62.3 4 446 2 441 Crystal structure of biotin carboxylase from haemophilus influenzae in complex with amppcp and mg2 1e-166 582 binding phosphomethylphosphonic acid adenylate ester 233 H 238 Q 26020841 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 4mv4:A 62.3 4 446 2 441 Crystal structure of biotin carboxylase from haemophilus influenzae in complex with amppcp and mg2 1e-166 582 binding phosphomethylphosphonic acid adenylate ester 275 L 280 L 26020841 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 4mv4:A 62.3 4 446 2 441 Crystal structure of biotin carboxylase from haemophilus influenzae in complex with amppcp and mg2 1e-166 582 binding phosphomethylphosphonic acid adenylate ester 285 E 290 E 26020841 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 4mv4:A 62.3 4 446 2 441 Crystal structure of biotin carboxylase from haemophilus influenzae in complex with amppcp and mg2 1e-166 582 binding magnesium ion 273 E 278 E 26020841 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 4mv4:A 62.3 4 446 2 441 Crystal structure of biotin carboxylase from haemophilus influenzae in complex with amppcp and mg2 1e-166 582 binding magnesium ion 285 E 290 E 26020841 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 6oi8:A 61.9 4 446 2 439 Crystal structure of haemophilus influenzae biotin carboxylase complexed with 7-((1r,5s,6s)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl)- 6-(2-chloro-6-(pyridin-3-yl)phenyl)pyrido[2,3-d]pyrimidin-2-amine 1e-164 577 active site 116 K 118 K 31306011 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 6oi8:A 61.9 4 446 2 439 Crystal structure of haemophilus influenzae biotin carboxylase complexed with 7-((1r,5s,6s)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl)- 6-(2-chloro-6-(pyridin-3-yl)phenyl)pyrido[2,3-d]pyrimidin-2-amine 1e-164 577 active site 159 K 161 K 31306011 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 6oi8:A 61.9 4 446 2 439 Crystal structure of haemophilus influenzae biotin carboxylase complexed with 7-((1r,5s,6s)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl)- 6-(2-chloro-6-(pyridin-3-yl)phenyl)pyrido[2,3-d]pyrimidin-2-amine 1e-164 577 active site 191 D 198 G 31306011 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 6oi8:A 61.9 4 446 2 439 Crystal structure of haemophilus influenzae biotin carboxylase complexed with 7-((1r,5s,6s)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl)- 6-(2-chloro-6-(pyridin-3-yl)phenyl)pyrido[2,3-d]pyrimidin-2-amine 1e-164 577 active site 204 H 211 H 31306011 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 6oi8:A 61.9 4 446 2 439 Crystal structure of haemophilus influenzae biotin carboxylase complexed with 7-((1r,5s,6s)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl)- 6-(2-chloro-6-(pyridin-3-yl)phenyl)pyrido[2,3-d]pyrimidin-2-amine 1e-164 577 active site 230 R 237 A 31306011 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 6oi8:A 61.9 4 446 2 439 Crystal structure of haemophilus influenzae biotin carboxylase complexed with 7-((1r,5s,6s)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl)- 6-(2-chloro-6-(pyridin-3-yl)phenyl)pyrido[2,3-d]pyrimidin-2-amine 1e-164 577 active site 269 T 276 T 31306011 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 6oi8:A 61.9 4 446 2 439 Crystal structure of haemophilus influenzae biotin carboxylase complexed with 7-((1r,5s,6s)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl)- 6-(2-chloro-6-(pyridin-3-yl)phenyl)pyrido[2,3-d]pyrimidin-2-amine 1e-164 577 active site 271 E 278 E 31306011 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 6oi8:A 61.9 4 446 2 439 Crystal structure of haemophilus influenzae biotin carboxylase complexed with 7-((1r,5s,6s)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl)- 6-(2-chloro-6-(pyridin-3-yl)phenyl)pyrido[2,3-d]pyrimidin-2-amine 1e-164 577 active site 283 E 290 E 31306011 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 6oi8:A 61.9 4 446 2 439 Crystal structure of haemophilus influenzae biotin carboxylase complexed with 7-((1r,5s,6s)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl)- 6-(2-chloro-6-(pyridin-3-yl)phenyl)pyrido[2,3-d]pyrimidin-2-amine 1e-164 577 active site 285 N 292 N 31306011 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 6oi8:A 61.9 4 446 2 439 Crystal structure of haemophilus influenzae biotin carboxylase complexed with 7-((1r,5s,6s)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl)- 6-(2-chloro-6-(pyridin-3-yl)phenyl)pyrido[2,3-d]pyrimidin-2-amine 1e-164 577 active site 287 R 294 R 31306011 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 6oi8:A 61.9 4 446 2 439 Crystal structure of haemophilus influenzae biotin carboxylase complexed with 7-((1r,5s,6s)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl)- 6-(2-chloro-6-(pyridin-3-yl)phenyl)pyrido[2,3-d]pyrimidin-2-amine 1e-164 577 active site 291 E 298 E 31306011 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 6oi8:A 61.9 4 446 2 439 Crystal structure of haemophilus influenzae biotin carboxylase complexed with 7-((1r,5s,6s)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl)- 6-(2-chloro-6-(pyridin-3-yl)phenyl)pyrido[2,3-d]pyrimidin-2-amine 1e-164 577 active site 333 R 340 R 31306011 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 6oi8:A 61.9 4 446 2 439 Crystal structure of haemophilus influenzae biotin carboxylase complexed with 7-((1r,5s,6s)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl)- 6-(2-chloro-6-(pyridin-3-yl)phenyl)pyrido[2,3-d]pyrimidin-2-amine 1e-164 577 binding 7-[(1R,5S,6s)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl]-6-[2-chloro-6-(pyridin-3-yl)phenyl]pyrido[2,3-d]pyrimidin-2-amine 157 I 159 I 31306011 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 6oi8:A 61.9 4 446 2 439 Crystal structure of haemophilus influenzae biotin carboxylase complexed with 7-((1r,5s,6s)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl)- 6-(2-chloro-6-(pyridin-3-yl)phenyl)pyrido[2,3-d]pyrimidin-2-amine 1e-164 577 binding 7-[(1R,5S,6s)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl]-6-[2-chloro-6-(pyridin-3-yl)phenyl]pyrido[2,3-d]pyrimidin-2-amine 159 K 161 K 31306011 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 6oi8:A 61.9 4 446 2 439 Crystal structure of haemophilus influenzae biotin carboxylase complexed with 7-((1r,5s,6s)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl)- 6-(2-chloro-6-(pyridin-3-yl)phenyl)pyrido[2,3-d]pyrimidin-2-amine 1e-164 577 binding 7-[(1R,5S,6s)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl]-6-[2-chloro-6-(pyridin-3-yl)phenyl]pyrido[2,3-d]pyrimidin-2-amine 164 M 171 M 31306011 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 6oi8:A 61.9 4 446 2 439 Crystal structure of haemophilus influenzae biotin carboxylase complexed with 7-((1r,5s,6s)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl)- 6-(2-chloro-6-(pyridin-3-yl)phenyl)pyrido[2,3-d]pyrimidin-2-amine 1e-164 577 binding 7-[(1R,5S,6s)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl]-6-[2-chloro-6-(pyridin-3-yl)phenyl]pyrido[2,3-d]pyrimidin-2-amine 196 E 203 E 31306011 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 6oi8:A 61.9 4 446 2 439 Crystal structure of haemophilus influenzae biotin carboxylase complexed with 7-((1r,5s,6s)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl)- 6-(2-chloro-6-(pyridin-3-yl)phenyl)pyrido[2,3-d]pyrimidin-2-amine 1e-164 577 binding 7-[(1R,5S,6s)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl]-6-[2-chloro-6-(pyridin-3-yl)phenyl]pyrido[2,3-d]pyrimidin-2-amine 198 Y 205 Y 31306011 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 6oi8:A 61.9 4 446 2 439 Crystal structure of haemophilus influenzae biotin carboxylase complexed with 7-((1r,5s,6s)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl)- 6-(2-chloro-6-(pyridin-3-yl)phenyl)pyrido[2,3-d]pyrimidin-2-amine 1e-164 577 binding 7-[(1R,5S,6s)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl]-6-[2-chloro-6-(pyridin-3-yl)phenyl]pyrido[2,3-d]pyrimidin-2-amine 199 L 206 L 31306011 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 6oi8:A 61.9 4 446 2 439 Crystal structure of haemophilus influenzae biotin carboxylase complexed with 7-((1r,5s,6s)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl)- 6-(2-chloro-6-(pyridin-3-yl)phenyl)pyrido[2,3-d]pyrimidin-2-amine 1e-164 577 binding 7-[(1R,5S,6s)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl]-6-[2-chloro-6-(pyridin-3-yl)phenyl]pyrido[2,3-d]pyrimidin-2-amine 204 H 211 H 31306011 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 6oi8:A 61.9 4 446 2 439 Crystal structure of haemophilus influenzae biotin carboxylase complexed with 7-((1r,5s,6s)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl)- 6-(2-chloro-6-(pyridin-3-yl)phenyl)pyrido[2,3-d]pyrimidin-2-amine 1e-164 577 binding 7-[(1R,5S,6s)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl]-6-[2-chloro-6-(pyridin-3-yl)phenyl]pyrido[2,3-d]pyrimidin-2-amine 228 Q 235 Q 31306011 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 6oi8:A 61.9 4 446 2 439 Crystal structure of haemophilus influenzae biotin carboxylase complexed with 7-((1r,5s,6s)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl)- 6-(2-chloro-6-(pyridin-3-yl)phenyl)pyrido[2,3-d]pyrimidin-2-amine 1e-164 577 binding 7-[(1R,5S,6s)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl]-6-[2-chloro-6-(pyridin-3-yl)phenyl]pyrido[2,3-d]pyrimidin-2-amine 271 E 278 E 31306011 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 6oi8:A 61.9 4 446 2 439 Crystal structure of haemophilus influenzae biotin carboxylase complexed with 7-((1r,5s,6s)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl)- 6-(2-chloro-6-(pyridin-3-yl)phenyl)pyrido[2,3-d]pyrimidin-2-amine 1e-164 577 binding 7-[(1R,5S,6s)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl]-6-[2-chloro-6-(pyridin-3-yl)phenyl]pyrido[2,3-d]pyrimidin-2-amine 273 L 280 L 31306011 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 6oi8:A 61.9 4 446 2 439 Crystal structure of haemophilus influenzae biotin carboxylase complexed with 7-((1r,5s,6s)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl)- 6-(2-chloro-6-(pyridin-3-yl)phenyl)pyrido[2,3-d]pyrimidin-2-amine 1e-164 577 binding 7-[(1R,5S,6s)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl]-6-[2-chloro-6-(pyridin-3-yl)phenyl]pyrido[2,3-d]pyrimidin-2-amine 283 E 290 E 31306011 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 6oi8:A 61.9 4 446 2 439 Crystal structure of haemophilus influenzae biotin carboxylase complexed with 7-((1r,5s,6s)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl)- 6-(2-chloro-6-(pyridin-3-yl)phenyl)pyrido[2,3-d]pyrimidin-2-amine 1e-164 577 binding 7-[(1R,5S,6s)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl]-6-[2-chloro-6-(pyridin-3-yl)phenyl]pyrido[2,3-d]pyrimidin-2-amine 432 I 439 I 31306011 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 4mv3:A 61.9 4 446 2 438 Crystal structure of biotin carboxylase from haemophilus influenzae in complex with amppcp and bicarbonate 1e-164 577 active site 116 K 118 K 26020841 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 4mv3:A 61.9 4 446 2 438 Crystal structure of biotin carboxylase from haemophilus influenzae in complex with amppcp and bicarbonate 1e-164 577 active site 159 K 161 K 26020841 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 4mv3:A 61.9 4 446 2 438 Crystal structure of biotin carboxylase from haemophilus influenzae in complex with amppcp and bicarbonate 1e-164 577 active site 190 D 198 G 26020841 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 4mv3:A 61.9 4 446 2 438 Crystal structure of biotin carboxylase from haemophilus influenzae in complex with amppcp and bicarbonate 1e-164 577 active site 203 H 211 H 26020841 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 4mv3:A 61.9 4 446 2 438 Crystal structure of biotin carboxylase from haemophilus influenzae in complex with amppcp and bicarbonate 1e-164 577 active site 229 R 237 A 26020841 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 4mv3:A 61.9 4 446 2 438 Crystal structure of biotin carboxylase from haemophilus influenzae in complex with amppcp and bicarbonate 1e-164 577 active site 268 T 276 T 26020841 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 4mv3:A 61.9 4 446 2 438 Crystal structure of biotin carboxylase from haemophilus influenzae in complex with amppcp and bicarbonate 1e-164 577 active site 270 E 278 E 26020841 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 4mv3:A 61.9 4 446 2 438 Crystal structure of biotin carboxylase from haemophilus influenzae in complex with amppcp and bicarbonate 1e-164 577 active site 282 E 290 E 26020841 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 4mv3:A 61.9 4 446 2 438 Crystal structure of biotin carboxylase from haemophilus influenzae in complex with amppcp and bicarbonate 1e-164 577 active site 284 N 292 N 26020841 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 4mv3:A 61.9 4 446 2 438 Crystal structure of biotin carboxylase from haemophilus influenzae in complex with amppcp and bicarbonate 1e-164 577 active site 286 R 294 R 26020841 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 4mv3:A 61.9 4 446 2 438 Crystal structure of biotin carboxylase from haemophilus influenzae in complex with amppcp and bicarbonate 1e-164 577 active site 290 E 298 E 26020841 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 4mv3:A 61.9 4 446 2 438 Crystal structure of biotin carboxylase from haemophilus influenzae in complex with amppcp and bicarbonate 1e-164 577 active site 332 R 340 R 26020841 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 4mv3:A 61.9 4 446 2 438 Crystal structure of biotin carboxylase from haemophilus influenzae in complex with amppcp and bicarbonate 1e-164 577 binding phosphomethylphosphonic acid adenylate ester 159 K 161 K 26020841 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 4mv3:A 61.9 4 446 2 438 Crystal structure of biotin carboxylase from haemophilus influenzae in complex with amppcp and bicarbonate 1e-164 577 binding phosphomethylphosphonic acid adenylate ester 163 M 171 M 26020841 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 4mv3:A 61.9 4 446 2 438 Crystal structure of biotin carboxylase from haemophilus influenzae in complex with amppcp and bicarbonate 1e-164 577 binding phosphomethylphosphonic acid adenylate ester 195 E 203 E 26020841 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 4mv3:A 61.9 4 446 2 438 Crystal structure of biotin carboxylase from haemophilus influenzae in complex with amppcp and bicarbonate 1e-164 577 binding phosphomethylphosphonic acid adenylate ester 197 Y 205 Y 26020841 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 4mv3:A 61.9 4 446 2 438 Crystal structure of biotin carboxylase from haemophilus influenzae in complex with amppcp and bicarbonate 1e-164 577 binding phosphomethylphosphonic acid adenylate ester 198 L 206 L 26020841 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 4mv3:A 61.9 4 446 2 438 Crystal structure of biotin carboxylase from haemophilus influenzae in complex with amppcp and bicarbonate 1e-164 577 binding phosphomethylphosphonic acid adenylate ester 270 E 278 E 26020841 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 4mv3:A 61.9 4 446 2 438 Crystal structure of biotin carboxylase from haemophilus influenzae in complex with amppcp and bicarbonate 1e-164 577 binding phosphomethylphosphonic acid adenylate ester 272 L 280 L 26020841 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 4mv3:A 61.9 4 446 2 438 Crystal structure of biotin carboxylase from haemophilus influenzae in complex with amppcp and bicarbonate 1e-164 577 binding phosphomethylphosphonic acid adenylate ester 282 E 290 E 26020841 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 4mv3:A 61.9 4 446 2 438 Crystal structure of biotin carboxylase from haemophilus influenzae in complex with amppcp and bicarbonate 1e-164 577 binding bicarbonate ion 286 R 294 R 26020841 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 4mv3:A 61.9 4 446 2 438 Crystal structure of biotin carboxylase from haemophilus influenzae in complex with amppcp and bicarbonate 1e-164 577 binding bicarbonate ion 288 Q 296 Q 26020841 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 4mv3:A 61.9 4 446 2 438 Crystal structure of biotin carboxylase from haemophilus influenzae in complex with amppcp and bicarbonate 1e-164 577 binding bicarbonate ion 289 V 297 V 26020841 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3rup:A 63.4 4 446 2 444 Crystal structure of e.Coli biotin carboxylase in complex with two adp and two ca ions 1e-164 575 active site 116 K 118 K 21592965 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3rup:A 63.4 4 446 2 444 Crystal structure of e.Coli biotin carboxylase in complex with two adp and two ca ions 1e-164 575 active site 159 K 161 K 21592965 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3rup:A 63.4 4 446 2 444 Crystal structure of e.Coli biotin carboxylase in complex with two adp and two ca ions 1e-164 575 active site 196 D 198 G 21592965 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3rup:A 63.4 4 446 2 444 Crystal structure of e.Coli biotin carboxylase in complex with two adp and two ca ions 1e-164 575 active site 209 H 211 H 21592965 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3rup:A 63.4 4 446 2 444 Crystal structure of e.Coli biotin carboxylase in complex with two adp and two ca ions 1e-164 575 active site 235 R 237 A 21592965 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3rup:A 63.4 4 446 2 444 Crystal structure of e.Coli biotin carboxylase in complex with two adp and two ca ions 1e-164 575 active site 274 T 276 T 21592965 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3rup:A 63.4 4 446 2 444 Crystal structure of e.Coli biotin carboxylase in complex with two adp and two ca ions 1e-164 575 active site 276 E 278 E 21592965 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3rup:A 63.4 4 446 2 444 Crystal structure of e.Coli biotin carboxylase in complex with two adp and two ca ions 1e-164 575 active site 288 E 290 E 21592965 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3rup:A 63.4 4 446 2 444 Crystal structure of e.Coli biotin carboxylase in complex with two adp and two ca ions 1e-164 575 active site 290 N 292 N 21592965 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3rup:A 63.4 4 446 2 444 Crystal structure of e.Coli biotin carboxylase in complex with two adp and two ca ions 1e-164 575 active site 292 R 294 R 21592965 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3rup:A 63.4 4 446 2 444 Crystal structure of e.Coli biotin carboxylase in complex with two adp and two ca ions 1e-164 575 active site 296 E 298 E 21592965 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3rup:A 63.4 4 446 2 444 Crystal structure of e.Coli biotin carboxylase in complex with two adp and two ca ions 1e-164 575 active site 338 R 340 R 21592965 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3rup:A 63.4 4 446 2 444 Crystal structure of e.Coli biotin carboxylase in complex with two adp and two ca ions 1e-164 575 binding adenosine-5'-diphosphate 82 Y 84 Y 21592965 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3rup:A 63.4 4 446 2 444 Crystal structure of e.Coli biotin carboxylase in complex with two adp and two ca ions 1e-164 575 binding adenosine-5'-diphosphate 83 G 85 G 21592965 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3rup:A 63.4 4 446 2 444 Crystal structure of e.Coli biotin carboxylase in complex with two adp and two ca ions 1e-164 575 binding adenosine-5'-diphosphate 116 K 118 K 21592965 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3rup:A 63.4 4 446 2 444 Crystal structure of e.Coli biotin carboxylase in complex with two adp and two ca ions 1e-164 575 binding adenosine-5'-diphosphate 159 K 161 K 21592965 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3rup:A 63.4 4 446 2 444 Crystal structure of e.Coli biotin carboxylase in complex with two adp and two ca ions 1e-164 575 binding adenosine-5'-diphosphate 164 G 166 G 21592965 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3rup:A 63.4 4 446 2 444 Crystal structure of e.Coli biotin carboxylase in complex with two adp and two ca ions 1e-164 575 binding adenosine-5'-diphosphate 164 G 166 G 21592965 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3rup:A 63.4 4 446 2 444 Crystal structure of e.Coli biotin carboxylase in complex with two adp and two ca ions 1e-164 575 binding adenosine-5'-diphosphate 165 G 167 G 21592965 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3rup:A 63.4 4 446 2 444 Crystal structure of e.Coli biotin carboxylase in complex with two adp and two ca ions 1e-164 575 binding adenosine-5'-diphosphate 166 G 168 G 21592965 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3rup:A 63.4 4 446 2 444 Crystal structure of e.Coli biotin carboxylase in complex with two adp and two ca ions 1e-164 575 binding adenosine-5'-diphosphate 167 R 169 K 21592965 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3rup:A 63.4 4 446 2 444 Crystal structure of e.Coli biotin carboxylase in complex with two adp and two ca ions 1e-164 575 binding adenosine-5'-diphosphate 169 M 171 M 21592965 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3rup:A 63.4 4 446 2 444 Crystal structure of e.Coli biotin carboxylase in complex with two adp and two ca ions 1e-164 575 binding adenosine-5'-diphosphate 193 F 195 F 21592965 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3rup:A 63.4 4 446 2 444 Crystal structure of e.Coli biotin carboxylase in complex with two adp and two ca ions 1e-164 575 binding adenosine-5'-diphosphate 201 E 203 E 21592965 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3rup:A 63.4 4 446 2 444 Crystal structure of e.Coli biotin carboxylase in complex with two adp and two ca ions 1e-164 575 binding adenosine-5'-diphosphate 202 K 204 K 21592965 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3rup:A 63.4 4 446 2 444 Crystal structure of e.Coli biotin carboxylase in complex with two adp and two ca ions 1e-164 575 binding adenosine-5'-diphosphate 203 Y 205 Y 21592965 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3rup:A 63.4 4 446 2 444 Crystal structure of e.Coli biotin carboxylase in complex with two adp and two ca ions 1e-164 575 binding adenosine-5'-diphosphate 204 L 206 L 21592965 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3rup:A 63.4 4 446 2 444 Crystal structure of e.Coli biotin carboxylase in complex with two adp and two ca ions 1e-164 575 binding adenosine-5'-diphosphate 209 H 211 H 21592965 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3rup:A 63.4 4 446 2 444 Crystal structure of e.Coli biotin carboxylase in complex with two adp and two ca ions 1e-164 575 binding adenosine-5'-diphosphate 233 Q 235 Q 21592965 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3rup:A 63.4 4 446 2 444 Crystal structure of e.Coli biotin carboxylase in complex with two adp and two ca ions 1e-164 575 binding adenosine-5'-diphosphate 236 H 238 Q 21592965 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3rup:A 63.4 4 446 2 444 Crystal structure of e.Coli biotin carboxylase in complex with two adp and two ca ions 1e-164 575 binding adenosine-5'-diphosphate 238 K 240 K 21592965 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3rup:A 63.4 4 446 2 444 Crystal structure of e.Coli biotin carboxylase in complex with two adp and two ca ions 1e-164 575 binding adenosine-5'-diphosphate 278 L 280 L 21592965 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3rup:A 63.4 4 446 2 444 Crystal structure of e.Coli biotin carboxylase in complex with two adp and two ca ions 1e-164 575 binding adenosine-5'-diphosphate 288 E 290 E 21592965 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3rup:A 63.4 4 446 2 444 Crystal structure of e.Coli biotin carboxylase in complex with two adp and two ca ions 1e-164 575 binding adenosine-5'-diphosphate 292 R 294 R 21592965 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3rup:A 63.4 4 446 2 444 Crystal structure of e.Coli biotin carboxylase in complex with two adp and two ca ions 1e-164 575 binding adenosine-5'-diphosphate 295 V 297 V 21592965 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3rup:A 63.4 4 446 2 444 Crystal structure of e.Coli biotin carboxylase in complex with two adp and two ca ions 1e-164 575 binding adenosine-5'-diphosphate 296 E 298 E 21592965 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3rup:A 63.4 4 446 2 444 Crystal structure of e.Coli biotin carboxylase in complex with two adp and two ca ions 1e-164 575 binding adenosine-5'-diphosphate 338 R 340 R 21592965 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3rup:A 63.4 4 446 2 444 Crystal structure of e.Coli biotin carboxylase in complex with two adp and two ca ions 1e-164 575 binding adenosine-5'-diphosphate 382 D 384 D 21592965 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3rup:A 63.4 4 446 2 444 Crystal structure of e.Coli biotin carboxylase in complex with two adp and two ca ions 1e-164 575 binding adenosine-5'-diphosphate 437 I 439 I 21592965 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3rup:A 63.4 4 446 2 444 Crystal structure of e.Coli biotin carboxylase in complex with two adp and two ca ions 1e-164 575 binding calcium ion 87 E 89 E 21592965 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3rup:A 63.4 4 446 2 444 Crystal structure of e.Coli biotin carboxylase in complex with two adp and two ca ions 1e-164 575 binding calcium ion 276 E 278 E 21592965 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3rup:A 63.4 4 446 2 444 Crystal structure of e.Coli biotin carboxylase in complex with two adp and two ca ions 1e-164 575 binding calcium ion 288 E 290 E 21592965 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3rup:A 63.4 4 446 2 444 Crystal structure of e.Coli biotin carboxylase in complex with two adp and two ca ions 1e-164 575 binding calcium ion 288 E 290 E 21592965 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3rup:A 63.4 4 446 2 444 Crystal structure of e.Coli biotin carboxylase in complex with two adp and two ca ions 1e-164 575 binding calcium ion 290 N 292 N 21592965 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3g8c:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase in complex with biotin, bicarbonate, adp and mg ion 1e-164 575 active site 116 K 118 K 19213731 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3g8c:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase in complex with biotin, bicarbonate, adp and mg ion 1e-164 575 active site 159 K 161 K 19213731 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3g8c:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase in complex with biotin, bicarbonate, adp and mg ion 1e-164 575 active site 196 D 198 G 19213731 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3g8c:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase in complex with biotin, bicarbonate, adp and mg ion 1e-164 575 active site 209 H 211 H 19213731 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3g8c:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase in complex with biotin, bicarbonate, adp and mg ion 1e-164 575 active site 235 R 237 A 19213731 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3g8c:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase in complex with biotin, bicarbonate, adp and mg ion 1e-164 575 active site 274 T 276 T 19213731 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3g8c:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase in complex with biotin, bicarbonate, adp and mg ion 1e-164 575 active site 276 E 278 E 19213731 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3g8c:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase in complex with biotin, bicarbonate, adp and mg ion 1e-164 575 active site 288 E 290 E 19213731 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3g8c:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase in complex with biotin, bicarbonate, adp and mg ion 1e-164 575 active site 290 N 292 N 19213731 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3g8c:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase in complex with biotin, bicarbonate, adp and mg ion 1e-164 575 active site 292 R 294 R 19213731 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3g8c:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase in complex with biotin, bicarbonate, adp and mg ion 1e-164 575 active site 296 E 298 E 19213731 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3g8c:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase in complex with biotin, bicarbonate, adp and mg ion 1e-164 575 active site 338 R 340 R 19213731 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3g8c:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase in complex with biotin, bicarbonate, adp and mg ion 1e-164 575 binding adenosine-5'-diphosphate 157 I 159 I 19213731 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3g8c:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase in complex with biotin, bicarbonate, adp and mg ion 1e-164 575 binding adenosine-5'-diphosphate 159 K 161 K 19213731 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3g8c:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase in complex with biotin, bicarbonate, adp and mg ion 1e-164 575 binding adenosine-5'-diphosphate 164 G 166 G 19213731 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3g8c:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase in complex with biotin, bicarbonate, adp and mg ion 1e-164 575 binding adenosine-5'-diphosphate 169 M 171 M 19213731 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3g8c:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase in complex with biotin, bicarbonate, adp and mg ion 1e-164 575 binding adenosine-5'-diphosphate 201 E 203 E 19213731 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3g8c:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase in complex with biotin, bicarbonate, adp and mg ion 1e-164 575 binding adenosine-5'-diphosphate 202 K 204 K 19213731 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3g8c:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase in complex with biotin, bicarbonate, adp and mg ion 1e-164 575 binding adenosine-5'-diphosphate 203 Y 205 Y 19213731 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3g8c:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase in complex with biotin, bicarbonate, adp and mg ion 1e-164 575 binding adenosine-5'-diphosphate 204 L 206 L 19213731 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3g8c:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase in complex with biotin, bicarbonate, adp and mg ion 1e-164 575 binding adenosine-5'-diphosphate 233 Q 235 Q 19213731 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3g8c:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase in complex with biotin, bicarbonate, adp and mg ion 1e-164 575 binding adenosine-5'-diphosphate 236 H 238 Q 19213731 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3g8c:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase in complex with biotin, bicarbonate, adp and mg ion 1e-164 575 binding adenosine-5'-diphosphate 278 L 280 L 19213731 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3g8c:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase in complex with biotin, bicarbonate, adp and mg ion 1e-164 575 binding adenosine-5'-diphosphate 288 E 290 E 19213731 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3g8c:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase in complex with biotin, bicarbonate, adp and mg ion 1e-164 575 binding adenosine-5'-diphosphate 437 I 439 I 19213731 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3g8c:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase in complex with biotin, bicarbonate, adp and mg ion 1e-164 575 binding bicarbonate ion 238 K 240 K 19213731 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3g8c:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase in complex with biotin, bicarbonate, adp and mg ion 1e-164 575 binding bicarbonate ion 292 R 294 R 19213731 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3g8c:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase in complex with biotin, bicarbonate, adp and mg ion 1e-164 575 binding bicarbonate ion 294 Q 296 Q 19213731 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3g8c:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase in complex with biotin, bicarbonate, adp and mg ion 1e-164 575 binding bicarbonate ion 295 V 297 V 19213731 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3g8c:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase in complex with biotin, bicarbonate, adp and mg ion 1e-164 575 binding bicarbonate ion 296 E 298 E 19213731 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3g8c:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase in complex with biotin, bicarbonate, adp and mg ion 1e-164 575 binding biotin 82 Y 84 Y 19213731 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3g8c:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase in complex with biotin, bicarbonate, adp and mg ion 1e-164 575 binding biotin 84 F 86 F 19213731 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3g8c:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase in complex with biotin, bicarbonate, adp and mg ion 1e-164 575 binding biotin 292 R 294 R 19213731 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3g8c:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase in complex with biotin, bicarbonate, adp and mg ion 1e-164 575 binding biotin 295 V 297 V 19213731 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3g8c:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase in complex with biotin, bicarbonate, adp and mg ion 1e-164 575 binding biotin 338 R 340 R 19213731 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3g8c:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase in complex with biotin, bicarbonate, adp and mg ion 1e-164 575 binding biotin 382 D 384 D 19213731 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3g8c:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase in complex with biotin, bicarbonate, adp and mg ion 1e-164 575 binding magnesium ion 276 E 278 E 19213731 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3g8c:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase in complex with biotin, bicarbonate, adp and mg ion 1e-164 575 binding magnesium ion 288 E 290 E 19213731 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3jzi:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with benzimidazole series 1e-164 575 active site 116 K 118 K 19875284 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3jzi:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with benzimidazole series 1e-164 575 active site 159 K 161 K 19875284 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3jzi:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with benzimidazole series 1e-164 575 active site 196 D 198 G 19875284 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3jzi:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with benzimidazole series 1e-164 575 active site 209 H 211 H 19875284 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3jzi:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with benzimidazole series 1e-164 575 active site 235 R 237 A 19875284 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3jzi:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with benzimidazole series 1e-164 575 active site 274 T 276 T 19875284 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3jzi:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with benzimidazole series 1e-164 575 active site 276 E 278 E 19875284 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3jzi:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with benzimidazole series 1e-164 575 active site 288 E 290 E 19875284 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3jzi:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with benzimidazole series 1e-164 575 active site 290 N 292 N 19875284 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3jzi:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with benzimidazole series 1e-164 575 active site 292 R 294 R 19875284 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3jzi:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with benzimidazole series 1e-164 575 active site 296 E 298 E 19875284 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3jzi:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with benzimidazole series 1e-164 575 active site 338 R 340 R 19875284 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3jzi:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with benzimidazole series 1e-164 575 binding 7-amino-2-[(2-chlorobenzyl)amino]-1-{[(1S,2S)-2-hydroxycycloheptyl]methyl}-1H-benzimidazole-5-carboxamide 116 K 118 K 19875284 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3jzi:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with benzimidazole series 1e-164 575 binding 7-amino-2-[(2-chlorobenzyl)amino]-1-{[(1S,2S)-2-hydroxycycloheptyl]methyl}-1H-benzimidazole-5-carboxamide 159 K 161 K 19875284 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3jzi:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with benzimidazole series 1e-164 575 binding 7-amino-2-[(2-chlorobenzyl)amino]-1-{[(1S,2S)-2-hydroxycycloheptyl]methyl}-1H-benzimidazole-5-carboxamide 160 A 162 A 19875284 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3jzi:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with benzimidazole series 1e-164 575 binding 7-amino-2-[(2-chlorobenzyl)amino]-1-{[(1S,2S)-2-hydroxycycloheptyl]methyl}-1H-benzimidazole-5-carboxamide 164 G 166 G 19875284 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3jzi:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with benzimidazole series 1e-164 575 binding 7-amino-2-[(2-chlorobenzyl)amino]-1-{[(1S,2S)-2-hydroxycycloheptyl]methyl}-1H-benzimidazole-5-carboxamide 165 G 167 G 19875284 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3jzi:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with benzimidazole series 1e-164 575 binding 7-amino-2-[(2-chlorobenzyl)amino]-1-{[(1S,2S)-2-hydroxycycloheptyl]methyl}-1H-benzimidazole-5-carboxamide 169 M 171 M 19875284 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3jzi:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with benzimidazole series 1e-164 575 binding 7-amino-2-[(2-chlorobenzyl)amino]-1-{[(1S,2S)-2-hydroxycycloheptyl]methyl}-1H-benzimidazole-5-carboxamide 199 Y 201 Y 19875284 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3jzi:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with benzimidazole series 1e-164 575 binding 7-amino-2-[(2-chlorobenzyl)amino]-1-{[(1S,2S)-2-hydroxycycloheptyl]methyl}-1H-benzimidazole-5-carboxamide 201 E 203 E 19875284 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3jzi:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with benzimidazole series 1e-164 575 binding 7-amino-2-[(2-chlorobenzyl)amino]-1-{[(1S,2S)-2-hydroxycycloheptyl]methyl}-1H-benzimidazole-5-carboxamide 202 K 204 K 19875284 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3jzi:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with benzimidazole series 1e-164 575 binding 7-amino-2-[(2-chlorobenzyl)amino]-1-{[(1S,2S)-2-hydroxycycloheptyl]methyl}-1H-benzimidazole-5-carboxamide 203 Y 205 Y 19875284 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3jzi:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with benzimidazole series 1e-164 575 binding 7-amino-2-[(2-chlorobenzyl)amino]-1-{[(1S,2S)-2-hydroxycycloheptyl]methyl}-1H-benzimidazole-5-carboxamide 209 H 211 H 19875284 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3jzi:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with benzimidazole series 1e-164 575 binding 7-amino-2-[(2-chlorobenzyl)amino]-1-{[(1S,2S)-2-hydroxycycloheptyl]methyl}-1H-benzimidazole-5-carboxamide 233 Q 235 Q 19875284 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3jzi:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with benzimidazole series 1e-164 575 binding 7-amino-2-[(2-chlorobenzyl)amino]-1-{[(1S,2S)-2-hydroxycycloheptyl]methyl}-1H-benzimidazole-5-carboxamide 236 H 238 Q 19875284 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3jzi:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with benzimidazole series 1e-164 575 binding 7-amino-2-[(2-chlorobenzyl)amino]-1-{[(1S,2S)-2-hydroxycycloheptyl]methyl}-1H-benzimidazole-5-carboxamide 278 L 280 L 19875284 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3jzi:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with benzimidazole series 1e-164 575 binding 7-amino-2-[(2-chlorobenzyl)amino]-1-{[(1S,2S)-2-hydroxycycloheptyl]methyl}-1H-benzimidazole-5-carboxamide 287 I 289 M 19875284 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 3jzi:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with benzimidazole series 1e-164 575 binding 7-amino-2-[(2-chlorobenzyl)amino]-1-{[(1S,2S)-2-hydroxycycloheptyl]methyl}-1H-benzimidazole-5-carboxamide 288 E 290 E 19875284 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6o:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with 4-amino-7,7-dimethyl-7,8-dihydro-quinazolinone fragment 1e-164 575 active site 116 K 118 K 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6o:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with 4-amino-7,7-dimethyl-7,8-dihydro-quinazolinone fragment 1e-164 575 active site 159 K 161 K 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6o:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with 4-amino-7,7-dimethyl-7,8-dihydro-quinazolinone fragment 1e-164 575 active site 196 D 198 G 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6o:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with 4-amino-7,7-dimethyl-7,8-dihydro-quinazolinone fragment 1e-164 575 active site 209 H 211 H 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6o:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with 4-amino-7,7-dimethyl-7,8-dihydro-quinazolinone fragment 1e-164 575 active site 235 R 237 A 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6o:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with 4-amino-7,7-dimethyl-7,8-dihydro-quinazolinone fragment 1e-164 575 active site 274 T 276 T 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6o:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with 4-amino-7,7-dimethyl-7,8-dihydro-quinazolinone fragment 1e-164 575 active site 276 E 278 E 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6o:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with 4-amino-7,7-dimethyl-7,8-dihydro-quinazolinone fragment 1e-164 575 active site 288 E 290 E 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6o:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with 4-amino-7,7-dimethyl-7,8-dihydro-quinazolinone fragment 1e-164 575 active site 290 N 292 N 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6o:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with 4-amino-7,7-dimethyl-7,8-dihydro-quinazolinone fragment 1e-164 575 active site 292 R 294 R 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6o:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with 4-amino-7,7-dimethyl-7,8-dihydro-quinazolinone fragment 1e-164 575 active site 296 E 298 E 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6o:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with 4-amino-7,7-dimethyl-7,8-dihydro-quinazolinone fragment 1e-164 575 active site 338 R 340 R 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6o:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with 4-amino-7,7-dimethyl-7,8-dihydro-quinazolinone fragment 1e-164 575 binding 4-amino-7,7-dimethyl-7,8-dihydroquinazolin-5(6H)-one 159 K 161 K 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6o:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with 4-amino-7,7-dimethyl-7,8-dihydro-quinazolinone fragment 1e-164 575 binding 4-amino-7,7-dimethyl-7,8-dihydroquinazolin-5(6H)-one 202 K 204 K 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6o:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with 4-amino-7,7-dimethyl-7,8-dihydro-quinazolinone fragment 1e-164 575 binding 4-amino-7,7-dimethyl-7,8-dihydroquinazolin-5(6H)-one 203 Y 205 Y 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6o:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with 4-amino-7,7-dimethyl-7,8-dihydro-quinazolinone fragment 1e-164 575 binding 4-amino-7,7-dimethyl-7,8-dihydroquinazolin-5(6H)-one 204 L 206 L 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6o:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with 4-amino-7,7-dimethyl-7,8-dihydro-quinazolinone fragment 1e-164 575 binding 4-amino-7,7-dimethyl-7,8-dihydroquinazolin-5(6H)-one 278 L 280 L 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6o:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with 4-amino-7,7-dimethyl-7,8-dihydro-quinazolinone fragment 1e-164 575 binding 4-amino-7,7-dimethyl-7,8-dihydroquinazolin-5(6H)-one 437 I 439 I 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6n:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with amino-oxazole fragment series 1e-164 575 active site 116 K 118 K 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6n:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with amino-oxazole fragment series 1e-164 575 active site 159 K 161 K 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6n:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with amino-oxazole fragment series 1e-164 575 active site 196 D 198 G 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6n:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with amino-oxazole fragment series 1e-164 575 active site 209 H 211 H 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6n:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with amino-oxazole fragment series 1e-164 575 active site 235 R 237 A 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6n:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with amino-oxazole fragment series 1e-164 575 active site 274 T 276 T 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6n:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with amino-oxazole fragment series 1e-164 575 active site 276 E 278 E 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6n:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with amino-oxazole fragment series 1e-164 575 active site 288 E 290 E 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6n:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with amino-oxazole fragment series 1e-164 575 active site 290 N 292 N 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6n:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with amino-oxazole fragment series 1e-164 575 active site 292 R 294 R 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6n:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with amino-oxazole fragment series 1e-164 575 active site 296 E 298 E 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6n:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with amino-oxazole fragment series 1e-164 575 active site 338 R 340 R 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6n:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with amino-oxazole fragment series 1e-164 575 binding 2-amino-n,n-bis(phenylmethyl)-1,3-oxazole-5-carboxamide 157 I 159 I 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6n:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with amino-oxazole fragment series 1e-164 575 binding 2-amino-n,n-bis(phenylmethyl)-1,3-oxazole-5-carboxamide 159 K 161 K 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6n:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with amino-oxazole fragment series 1e-164 575 binding 2-amino-n,n-bis(phenylmethyl)-1,3-oxazole-5-carboxamide 169 M 171 M 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6n:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with amino-oxazole fragment series 1e-164 575 binding 2-amino-n,n-bis(phenylmethyl)-1,3-oxazole-5-carboxamide 201 E 203 E 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6n:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with amino-oxazole fragment series 1e-164 575 binding 2-amino-n,n-bis(phenylmethyl)-1,3-oxazole-5-carboxamide 202 K 204 K 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6n:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with amino-oxazole fragment series 1e-164 575 binding 2-amino-n,n-bis(phenylmethyl)-1,3-oxazole-5-carboxamide 203 Y 205 Y 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6n:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with amino-oxazole fragment series 1e-164 575 binding 2-amino-n,n-bis(phenylmethyl)-1,3-oxazole-5-carboxamide 278 L 280 L 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v59:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 2 1e-164 575 active site 116 K 118 K 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v59:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 2 1e-164 575 active site 159 K 161 K 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v59:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 2 1e-164 575 active site 196 D 198 G 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v59:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 2 1e-164 575 active site 209 H 211 H 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v59:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 2 1e-164 575 active site 235 R 237 A 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v59:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 2 1e-164 575 active site 274 T 276 T 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v59:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 2 1e-164 575 active site 276 E 278 E 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v59:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 2 1e-164 575 active site 288 E 290 E 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v59:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 2 1e-164 575 active site 290 N 292 N 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v59:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 2 1e-164 575 active site 292 R 294 R 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v59:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 2 1e-164 575 active site 296 E 298 E 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v59:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 2 1e-164 575 active site 338 R 340 R 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v59:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 2 1e-164 575 binding 6-(2,6-dimethoxyphenyl)pyrido[2,3-d]pyrimidine-2,7-diamine 159 K 161 K 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v59:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 2 1e-164 575 binding 6-(2,6-dimethoxyphenyl)pyrido[2,3-d]pyrimidine-2,7-diamine 203 Y 205 Y 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v59:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 2 1e-164 575 binding 6-(2,6-dimethoxyphenyl)pyrido[2,3-d]pyrimidine-2,7-diamine 204 L 206 L 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v59:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 2 1e-164 575 binding 6-(2,6-dimethoxyphenyl)pyrido[2,3-d]pyrimidine-2,7-diamine 209 H 211 H 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v59:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 2 1e-164 575 binding 6-(2,6-dimethoxyphenyl)pyrido[2,3-d]pyrimidine-2,7-diamine 233 Q 235 Q 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v59:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 2 1e-164 575 binding 6-(2,6-dimethoxyphenyl)pyrido[2,3-d]pyrimidine-2,7-diamine 236 H 238 Q 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v59:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 2 1e-164 575 binding 6-(2,6-dimethoxyphenyl)pyrido[2,3-d]pyrimidine-2,7-diamine 278 L 280 L 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v59:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 2 1e-164 575 binding 6-(2,6-dimethoxyphenyl)pyrido[2,3-d]pyrimidine-2,7-diamine 437 I 439 I 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 6oi9:A 63.4 4 446 2 444 Crystal structure of e. Coli biotin carboxylase complexed with 7-[3- (aminomethyl)pyrrolidin-1-yl]-6-(2,6-dichlorophenyl)pyrido[2,3- d]pyrimidin-2-amine 1e-164 575 active site 276 E 278 E 31306011 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 6oi9:A 63.4 4 446 2 444 Crystal structure of e. Coli biotin carboxylase complexed with 7-[3- (aminomethyl)pyrrolidin-1-yl]-6-(2,6-dichlorophenyl)pyrido[2,3- d]pyrimidin-2-amine 1e-164 575 active site 288 E 290 E 31306011 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 6oi9:A 63.4 4 446 2 444 Crystal structure of e. Coli biotin carboxylase complexed with 7-[3- (aminomethyl)pyrrolidin-1-yl]-6-(2,6-dichlorophenyl)pyrido[2,3- d]pyrimidin-2-amine 1e-164 575 active site 290 N 292 N 31306011 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 6oi9:A 63.4 4 446 2 444 Crystal structure of e. Coli biotin carboxylase complexed with 7-[3- (aminomethyl)pyrrolidin-1-yl]-6-(2,6-dichlorophenyl)pyrido[2,3- d]pyrimidin-2-amine 1e-164 575 active site 296 E 298 E 31306011 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 6oi9:A 63.4 4 446 2 444 Crystal structure of e. Coli biotin carboxylase complexed with 7-[3- (aminomethyl)pyrrolidin-1-yl]-6-(2,6-dichlorophenyl)pyrido[2,3- d]pyrimidin-2-amine 1e-164 575 active site 338 R 340 R 31306011 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 6oi9:A 63.4 4 446 2 444 Crystal structure of e. Coli biotin carboxylase complexed with 7-[3- (aminomethyl)pyrrolidin-1-yl]-6-(2,6-dichlorophenyl)pyrido[2,3- d]pyrimidin-2-amine 1e-164 575 binding 7-[(3S)-3-(aminomethyl)pyrrolidin-1-yl]-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-2-amine 159 K 161 K 31306011 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 6oi9:A 63.4 4 446 2 444 Crystal structure of e. Coli biotin carboxylase complexed with 7-[3- (aminomethyl)pyrrolidin-1-yl]-6-(2,6-dichlorophenyl)pyrido[2,3- d]pyrimidin-2-amine 1e-164 575 binding 7-[(3S)-3-(aminomethyl)pyrrolidin-1-yl]-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-2-amine 169 M 171 M 31306011 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 6oi9:A 63.4 4 446 2 444 Crystal structure of e. Coli biotin carboxylase complexed with 7-[3- (aminomethyl)pyrrolidin-1-yl]-6-(2,6-dichlorophenyl)pyrido[2,3- d]pyrimidin-2-amine 1e-164 575 binding 7-[(3S)-3-(aminomethyl)pyrrolidin-1-yl]-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-2-amine 201 E 203 E 31306011 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 6oi9:A 63.4 4 446 2 444 Crystal structure of e. Coli biotin carboxylase complexed with 7-[3- (aminomethyl)pyrrolidin-1-yl]-6-(2,6-dichlorophenyl)pyrido[2,3- d]pyrimidin-2-amine 1e-164 575 binding 7-[(3S)-3-(aminomethyl)pyrrolidin-1-yl]-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-2-amine 203 Y 205 Y 31306011 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 6oi9:A 63.4 4 446 2 444 Crystal structure of e. Coli biotin carboxylase complexed with 7-[3- (aminomethyl)pyrrolidin-1-yl]-6-(2,6-dichlorophenyl)pyrido[2,3- d]pyrimidin-2-amine 1e-164 575 binding 7-[(3S)-3-(aminomethyl)pyrrolidin-1-yl]-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-2-amine 204 L 206 L 31306011 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 6oi9:A 63.4 4 446 2 444 Crystal structure of e. Coli biotin carboxylase complexed with 7-[3- (aminomethyl)pyrrolidin-1-yl]-6-(2,6-dichlorophenyl)pyrido[2,3- d]pyrimidin-2-amine 1e-164 575 binding 7-[(3S)-3-(aminomethyl)pyrrolidin-1-yl]-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-2-amine 209 H 211 H 31306011 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 6oi9:A 63.4 4 446 2 444 Crystal structure of e. Coli biotin carboxylase complexed with 7-[3- (aminomethyl)pyrrolidin-1-yl]-6-(2,6-dichlorophenyl)pyrido[2,3- d]pyrimidin-2-amine 1e-164 575 binding 7-[(3S)-3-(aminomethyl)pyrrolidin-1-yl]-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-2-amine 233 Q 235 Q 31306011 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 6oi9:A 63.4 4 446 2 444 Crystal structure of e. Coli biotin carboxylase complexed with 7-[3- (aminomethyl)pyrrolidin-1-yl]-6-(2,6-dichlorophenyl)pyrido[2,3- d]pyrimidin-2-amine 1e-164 575 binding 7-[(3S)-3-(aminomethyl)pyrrolidin-1-yl]-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-2-amine 236 H 238 Q 31306011 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 6oi9:A 63.4 4 446 2 444 Crystal structure of e. Coli biotin carboxylase complexed with 7-[3- (aminomethyl)pyrrolidin-1-yl]-6-(2,6-dichlorophenyl)pyrido[2,3- d]pyrimidin-2-amine 1e-164 575 binding 7-[(3S)-3-(aminomethyl)pyrrolidin-1-yl]-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-2-amine 276 E 278 E 31306011 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 6oi9:A 63.4 4 446 2 444 Crystal structure of e. Coli biotin carboxylase complexed with 7-[3- (aminomethyl)pyrrolidin-1-yl]-6-(2,6-dichlorophenyl)pyrido[2,3- d]pyrimidin-2-amine 1e-164 575 binding 7-[(3S)-3-(aminomethyl)pyrrolidin-1-yl]-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-2-amine 278 L 280 L 31306011 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 6oi9:A 63.4 4 446 2 444 Crystal structure of e. Coli biotin carboxylase complexed with 7-[3- (aminomethyl)pyrrolidin-1-yl]-6-(2,6-dichlorophenyl)pyrido[2,3- d]pyrimidin-2-amine 1e-164 575 binding 7-[(3S)-3-(aminomethyl)pyrrolidin-1-yl]-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-2-amine 288 E 290 E 31306011 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 6oi9:A 63.4 4 446 2 444 Crystal structure of e. Coli biotin carboxylase complexed with 7-[3- (aminomethyl)pyrrolidin-1-yl]-6-(2,6-dichlorophenyl)pyrido[2,3- d]pyrimidin-2-amine 1e-164 575 binding 7-[(3S)-3-(aminomethyl)pyrrolidin-1-yl]-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-2-amine 437 I 439 I 31306011 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w71:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the imidazole-pyrimidine inhibitor 1e-164 575 active site 116 K 118 K 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w71:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the imidazole-pyrimidine inhibitor 1e-164 575 active site 159 K 161 K 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w71:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the imidazole-pyrimidine inhibitor 1e-164 575 active site 196 D 198 G 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w71:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the imidazole-pyrimidine inhibitor 1e-164 575 active site 209 H 211 H 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w71:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the imidazole-pyrimidine inhibitor 1e-164 575 active site 235 R 237 A 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w71:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the imidazole-pyrimidine inhibitor 1e-164 575 active site 274 T 276 T 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w71:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the imidazole-pyrimidine inhibitor 1e-164 575 active site 276 E 278 E 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w71:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the imidazole-pyrimidine inhibitor 1e-164 575 active site 288 E 290 E 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w71:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the imidazole-pyrimidine inhibitor 1e-164 575 active site 290 N 292 N 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w71:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the imidazole-pyrimidine inhibitor 1e-164 575 active site 292 R 294 R 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w71:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the imidazole-pyrimidine inhibitor 1e-164 575 active site 296 E 298 E 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w71:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the imidazole-pyrimidine inhibitor 1e-164 575 active site 338 R 340 R 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w71:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the imidazole-pyrimidine inhibitor 1e-164 575 binding 4-[1-(2,6-dichlorobenzyl)-2-methyl-1H-imidazol-4-yl]pyrimidin-2-amine 159 K 161 K 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w71:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the imidazole-pyrimidine inhibitor 1e-164 575 binding 4-[1-(2,6-dichlorobenzyl)-2-methyl-1H-imidazol-4-yl]pyrimidin-2-amine 203 Y 205 Y 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w71:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the imidazole-pyrimidine inhibitor 1e-164 575 binding 4-[1-(2,6-dichlorobenzyl)-2-methyl-1H-imidazol-4-yl]pyrimidin-2-amine 204 L 206 L 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w71:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the imidazole-pyrimidine inhibitor 1e-164 575 binding 4-[1-(2,6-dichlorobenzyl)-2-methyl-1H-imidazol-4-yl]pyrimidin-2-amine 209 H 211 H 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w71:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the imidazole-pyrimidine inhibitor 1e-164 575 binding 4-[1-(2,6-dichlorobenzyl)-2-methyl-1H-imidazol-4-yl]pyrimidin-2-amine 233 Q 235 Q 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w71:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the imidazole-pyrimidine inhibitor 1e-164 575 binding 4-[1-(2,6-dichlorobenzyl)-2-methyl-1H-imidazol-4-yl]pyrimidin-2-amine 236 H 238 Q 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w71:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the imidazole-pyrimidine inhibitor 1e-164 575 binding 4-[1-(2,6-dichlorobenzyl)-2-methyl-1H-imidazol-4-yl]pyrimidin-2-amine 278 L 280 L 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w71:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the imidazole-pyrimidine inhibitor 1e-164 575 binding 4-[1-(2,6-dichlorobenzyl)-2-methyl-1H-imidazol-4-yl]pyrimidin-2-amine 437 I 439 I 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w70:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the amino-thiazole-pyrimidine fragment 1e-164 575 active site 116 K 118 K 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w70:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the amino-thiazole-pyrimidine fragment 1e-164 575 active site 159 K 161 K 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w70:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the amino-thiazole-pyrimidine fragment 1e-164 575 active site 196 D 198 G 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w70:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the amino-thiazole-pyrimidine fragment 1e-164 575 active site 209 H 211 H 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w70:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the amino-thiazole-pyrimidine fragment 1e-164 575 active site 235 R 237 A 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w70:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the amino-thiazole-pyrimidine fragment 1e-164 575 active site 274 T 276 T 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w70:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the amino-thiazole-pyrimidine fragment 1e-164 575 active site 276 E 278 E 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w70:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the amino-thiazole-pyrimidine fragment 1e-164 575 active site 288 E 290 E 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w70:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the amino-thiazole-pyrimidine fragment 1e-164 575 active site 290 N 292 N 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w70:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the amino-thiazole-pyrimidine fragment 1e-164 575 active site 292 R 294 R 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w70:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the amino-thiazole-pyrimidine fragment 1e-164 575 active site 296 E 298 E 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w70:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the amino-thiazole-pyrimidine fragment 1e-164 575 active site 338 R 340 R 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w70:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the amino-thiazole-pyrimidine fragment 1e-164 575 binding 4-(2-amino-1,3-thiazol-4-yl)pyrimidin-2-amine 157 I 159 I 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w70:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the amino-thiazole-pyrimidine fragment 1e-164 575 binding 4-(2-amino-1,3-thiazol-4-yl)pyrimidin-2-amine 159 K 161 K 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w70:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the amino-thiazole-pyrimidine fragment 1e-164 575 binding 4-(2-amino-1,3-thiazol-4-yl)pyrimidin-2-amine 166 G 168 G 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w70:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the amino-thiazole-pyrimidine fragment 1e-164 575 binding 4-(2-amino-1,3-thiazol-4-yl)pyrimidin-2-amine 169 M 171 M 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w70:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the amino-thiazole-pyrimidine fragment 1e-164 575 binding 4-(2-amino-1,3-thiazol-4-yl)pyrimidin-2-amine 201 E 203 E 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w70:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the amino-thiazole-pyrimidine fragment 1e-164 575 binding 4-(2-amino-1,3-thiazol-4-yl)pyrimidin-2-amine 203 Y 205 Y 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w70:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the amino-thiazole-pyrimidine fragment 1e-164 575 binding 4-(2-amino-1,3-thiazol-4-yl)pyrimidin-2-amine 204 L 206 L 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w70:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the amino-thiazole-pyrimidine fragment 1e-164 575 binding 4-(2-amino-1,3-thiazol-4-yl)pyrimidin-2-amine 278 L 280 L 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6z:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the 3-(3-methyl-but-2-enyl)-3h-purin-6-ylamine fragment 1e-164 575 active site 116 K 118 K 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6z:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the 3-(3-methyl-but-2-enyl)-3h-purin-6-ylamine fragment 1e-164 575 active site 159 K 161 K 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6z:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the 3-(3-methyl-but-2-enyl)-3h-purin-6-ylamine fragment 1e-164 575 active site 196 D 198 G 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6z:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the 3-(3-methyl-but-2-enyl)-3h-purin-6-ylamine fragment 1e-164 575 active site 209 H 211 H 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6z:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the 3-(3-methyl-but-2-enyl)-3h-purin-6-ylamine fragment 1e-164 575 active site 235 R 237 A 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6z:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the 3-(3-methyl-but-2-enyl)-3h-purin-6-ylamine fragment 1e-164 575 active site 274 T 276 T 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6z:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the 3-(3-methyl-but-2-enyl)-3h-purin-6-ylamine fragment 1e-164 575 active site 276 E 278 E 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6z:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the 3-(3-methyl-but-2-enyl)-3h-purin-6-ylamine fragment 1e-164 575 active site 288 E 290 E 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6z:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the 3-(3-methyl-but-2-enyl)-3h-purin-6-ylamine fragment 1e-164 575 active site 290 N 292 N 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6z:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the 3-(3-methyl-but-2-enyl)-3h-purin-6-ylamine fragment 1e-164 575 active site 292 R 294 R 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6z:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the 3-(3-methyl-but-2-enyl)-3h-purin-6-ylamine fragment 1e-164 575 active site 296 E 298 E 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6z:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the 3-(3-methyl-but-2-enyl)-3h-purin-6-ylamine fragment 1e-164 575 active site 338 R 340 R 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6z:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the 3-(3-methyl-but-2-enyl)-3h-purin-6-ylamine fragment 1e-164 575 binding 3-(3-methylbut-2-en-1-yl)-3H-purin-6-amine 159 K 161 K 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6z:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the 3-(3-methyl-but-2-enyl)-3h-purin-6-ylamine fragment 1e-164 575 binding 3-(3-methylbut-2-en-1-yl)-3H-purin-6-amine 203 Y 205 Y 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6z:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the 3-(3-methyl-but-2-enyl)-3h-purin-6-ylamine fragment 1e-164 575 binding 3-(3-methylbut-2-en-1-yl)-3H-purin-6-amine 204 L 206 L 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6z:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the 3-(3-methyl-but-2-enyl)-3h-purin-6-ylamine fragment 1e-164 575 binding 3-(3-methylbut-2-en-1-yl)-3H-purin-6-amine 278 L 280 L 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6q:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the triazine-2,4-diamine fragment 1e-164 575 active site 116 K 118 K 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6q:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the triazine-2,4-diamine fragment 1e-164 575 active site 159 K 161 K 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6q:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the triazine-2,4-diamine fragment 1e-164 575 active site 196 D 198 G 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6q:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the triazine-2,4-diamine fragment 1e-164 575 active site 209 H 211 H 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6q:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the triazine-2,4-diamine fragment 1e-164 575 active site 235 R 237 A 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6q:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the triazine-2,4-diamine fragment 1e-164 575 active site 274 T 276 T 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6q:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the triazine-2,4-diamine fragment 1e-164 575 active site 276 E 278 E 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6q:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the triazine-2,4-diamine fragment 1e-164 575 active site 288 E 290 E 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6q:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the triazine-2,4-diamine fragment 1e-164 575 active site 290 N 292 N 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6q:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the triazine-2,4-diamine fragment 1e-164 575 active site 292 R 294 R 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6q:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the triazine-2,4-diamine fragment 1e-164 575 active site 296 E 298 E 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6q:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the triazine-2,4-diamine fragment 1e-164 575 active site 338 R 340 R 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6q:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the triazine-2,4-diamine fragment 1e-164 575 binding 6-(2-phenoxyethoxy)-1,3,5-triazine-2,4-diamine 157 I 159 I 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6q:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the triazine-2,4-diamine fragment 1e-164 575 binding 6-(2-phenoxyethoxy)-1,3,5-triazine-2,4-diamine 159 K 161 K 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6q:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the triazine-2,4-diamine fragment 1e-164 575 binding 6-(2-phenoxyethoxy)-1,3,5-triazine-2,4-diamine 201 E 203 E 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6q:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the triazine-2,4-diamine fragment 1e-164 575 binding 6-(2-phenoxyethoxy)-1,3,5-triazine-2,4-diamine 202 K 204 K 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6q:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the triazine-2,4-diamine fragment 1e-164 575 binding 6-(2-phenoxyethoxy)-1,3,5-triazine-2,4-diamine 203 Y 205 Y 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6q:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the triazine-2,4-diamine fragment 1e-164 575 binding 6-(2-phenoxyethoxy)-1,3,5-triazine-2,4-diamine 204 L 206 L 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6q:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the triazine-2,4-diamine fragment 1e-164 575 binding 6-(2-phenoxyethoxy)-1,3,5-triazine-2,4-diamine 236 H 238 Q 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6q:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with the triazine-2,4-diamine fragment 1e-164 575 binding 6-(2-phenoxyethoxy)-1,3,5-triazine-2,4-diamine 278 L 280 L 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6p:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with 5-methyl-6-phenyl-quinazoline-2,4-diamine 1e-164 575 active site 116 K 118 K 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6p:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with 5-methyl-6-phenyl-quinazoline-2,4-diamine 1e-164 575 active site 159 K 161 K 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6p:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with 5-methyl-6-phenyl-quinazoline-2,4-diamine 1e-164 575 active site 196 D 198 G 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6p:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with 5-methyl-6-phenyl-quinazoline-2,4-diamine 1e-164 575 active site 209 H 211 H 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6p:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with 5-methyl-6-phenyl-quinazoline-2,4-diamine 1e-164 575 active site 235 R 237 A 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6p:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with 5-methyl-6-phenyl-quinazoline-2,4-diamine 1e-164 575 active site 274 T 276 T 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6p:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with 5-methyl-6-phenyl-quinazoline-2,4-diamine 1e-164 575 active site 276 E 278 E 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6p:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with 5-methyl-6-phenyl-quinazoline-2,4-diamine 1e-164 575 active site 288 E 290 E 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6p:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with 5-methyl-6-phenyl-quinazoline-2,4-diamine 1e-164 575 active site 290 N 292 N 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6p:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with 5-methyl-6-phenyl-quinazoline-2,4-diamine 1e-164 575 active site 292 R 294 R 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6p:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with 5-methyl-6-phenyl-quinazoline-2,4-diamine 1e-164 575 active site 296 E 298 E 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6p:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with 5-methyl-6-phenyl-quinazoline-2,4-diamine 1e-164 575 active site 338 R 340 R 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6p:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with 5-methyl-6-phenyl-quinazoline-2,4-diamine 1e-164 575 binding 5-methyl-6-phenylquinazoline-2,4-diamine 159 K 161 K 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6p:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with 5-methyl-6-phenyl-quinazoline-2,4-diamine 1e-164 575 binding 5-methyl-6-phenylquinazoline-2,4-diamine 203 Y 205 Y 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6p:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with 5-methyl-6-phenyl-quinazoline-2,4-diamine 1e-164 575 binding 5-methyl-6-phenylquinazoline-2,4-diamine 204 L 206 L 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6p:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with 5-methyl-6-phenyl-quinazoline-2,4-diamine 1e-164 575 binding 5-methyl-6-phenylquinazoline-2,4-diamine 233 Q 235 Q 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6p:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with 5-methyl-6-phenyl-quinazoline-2,4-diamine 1e-164 575 binding 5-methyl-6-phenylquinazoline-2,4-diamine 236 H 238 Q 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6p:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with 5-methyl-6-phenyl-quinazoline-2,4-diamine 1e-164 575 binding 5-methyl-6-phenylquinazoline-2,4-diamine 278 L 280 L 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6p:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with 5-methyl-6-phenyl-quinazoline-2,4-diamine 1e-164 575 binding 5-methyl-6-phenylquinazoline-2,4-diamine 437 I 439 I 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6m:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with amino-oxazole fragment series 1e-164 575 active site 116 K 118 K 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6m:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with amino-oxazole fragment series 1e-164 575 active site 159 K 161 K 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6m:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with amino-oxazole fragment series 1e-164 575 active site 196 D 198 G 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6m:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with amino-oxazole fragment series 1e-164 575 active site 209 H 211 H 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6m:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with amino-oxazole fragment series 1e-164 575 active site 235 R 237 A 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6m:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with amino-oxazole fragment series 1e-164 575 active site 274 T 276 T 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6m:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with amino-oxazole fragment series 1e-164 575 active site 276 E 278 E 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6m:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with amino-oxazole fragment series 1e-164 575 active site 288 E 290 E 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6m:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with amino-oxazole fragment series 1e-164 575 active site 290 N 292 N 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6m:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with amino-oxazole fragment series 1e-164 575 active site 292 R 294 R 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6m:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with amino-oxazole fragment series 1e-164 575 active site 296 E 298 E 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6m:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with amino-oxazole fragment series 1e-164 575 active site 338 R 340 R 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6m:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with amino-oxazole fragment series 1e-164 575 binding (2-amino-1,3-oxazol-5-yl)-(3-bromophenyl)methanone 157 I 159 I 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6m:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with amino-oxazole fragment series 1e-164 575 binding (2-amino-1,3-oxazol-5-yl)-(3-bromophenyl)methanone 159 K 161 K 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6m:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with amino-oxazole fragment series 1e-164 575 binding (2-amino-1,3-oxazol-5-yl)-(3-bromophenyl)methanone 169 M 171 M 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6m:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with amino-oxazole fragment series 1e-164 575 binding (2-amino-1,3-oxazol-5-yl)-(3-bromophenyl)methanone 201 E 203 E 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6m:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with amino-oxazole fragment series 1e-164 575 binding (2-amino-1,3-oxazol-5-yl)-(3-bromophenyl)methanone 202 K 204 K 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6m:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with amino-oxazole fragment series 1e-164 575 binding (2-amino-1,3-oxazol-5-yl)-(3-bromophenyl)methanone 203 Y 205 Y 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6m:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with amino-oxazole fragment series 1e-164 575 binding (2-amino-1,3-oxazol-5-yl)-(3-bromophenyl)methanone 236 H 238 Q 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6m:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with amino-oxazole fragment series 1e-164 575 binding (2-amino-1,3-oxazol-5-yl)-(3-bromophenyl)methanone 278 L 280 L 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2w6m:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e. Coli in complex with amino-oxazole fragment series 1e-164 575 binding (2-amino-1,3-oxazol-5-yl)-(3-bromophenyl)methanone 437 I 439 I 19413326 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v5a:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 3 1e-164 575 active site 116 K 118 K 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v5a:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 3 1e-164 575 active site 159 K 161 K 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v5a:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 3 1e-164 575 active site 196 D 198 G 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v5a:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 3 1e-164 575 active site 209 H 211 H 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v5a:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 3 1e-164 575 active site 235 R 237 A 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v5a:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 3 1e-164 575 active site 274 T 276 T 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v5a:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 3 1e-164 575 active site 276 E 278 E 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v5a:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 3 1e-164 575 active site 288 E 290 E 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v5a:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 3 1e-164 575 active site 290 N 292 N 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v5a:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 3 1e-164 575 active site 292 R 294 R 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v5a:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 3 1e-164 575 active site 296 E 298 E 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v5a:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 3 1e-164 575 active site 338 R 340 R 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v5a:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 3 1e-164 575 binding 7-(2,5-dihydropyrrol-1-yl)-6-phenyl-pyrido[6,5-d]pyrimidin-2-amine 157 I 159 I 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v5a:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 3 1e-164 575 binding 7-(2,5-dihydropyrrol-1-yl)-6-phenyl-pyrido[6,5-d]pyrimidin-2-amine 159 K 161 K 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v5a:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 3 1e-164 575 binding 7-(2,5-dihydropyrrol-1-yl)-6-phenyl-pyrido[6,5-d]pyrimidin-2-amine 169 M 171 M 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v5a:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 3 1e-164 575 binding 7-(2,5-dihydropyrrol-1-yl)-6-phenyl-pyrido[6,5-d]pyrimidin-2-amine 201 E 203 E 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v5a:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 3 1e-164 575 binding 7-(2,5-dihydropyrrol-1-yl)-6-phenyl-pyrido[6,5-d]pyrimidin-2-amine 203 Y 205 Y 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v5a:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 3 1e-164 575 binding 7-(2,5-dihydropyrrol-1-yl)-6-phenyl-pyrido[6,5-d]pyrimidin-2-amine 204 L 206 L 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v5a:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 3 1e-164 575 binding 7-(2,5-dihydropyrrol-1-yl)-6-phenyl-pyrido[6,5-d]pyrimidin-2-amine 233 Q 235 Q 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v5a:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 3 1e-164 575 binding 7-(2,5-dihydropyrrol-1-yl)-6-phenyl-pyrido[6,5-d]pyrimidin-2-amine 236 H 238 Q 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v5a:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 3 1e-164 575 binding 7-(2,5-dihydropyrrol-1-yl)-6-phenyl-pyrido[6,5-d]pyrimidin-2-amine 278 L 280 L 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v5a:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 3 1e-164 575 binding 7-(2,5-dihydropyrrol-1-yl)-6-phenyl-pyrido[6,5-d]pyrimidin-2-amine 437 I 439 I 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v58:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 1 1e-164 575 active site 116 K 118 K 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v58:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 1 1e-164 575 active site 159 K 161 K 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v58:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 1 1e-164 575 active site 196 D 198 G 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v58:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 1 1e-164 575 active site 209 H 211 H 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v58:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 1 1e-164 575 active site 235 R 237 A 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v58:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 1 1e-164 575 active site 274 T 276 T 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v58:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 1 1e-164 575 active site 276 E 278 E 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v58:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 1 1e-164 575 active site 288 E 290 E 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v58:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 1 1e-164 575 active site 290 N 292 N 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v58:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 1 1e-164 575 active site 292 R 294 R 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v58:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 1 1e-164 575 active site 296 E 298 E 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v58:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 1 1e-164 575 active site 338 R 340 R 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v58:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 1 1e-164 575 binding 6-(2,6-dibromophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine 157 I 159 I 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v58:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 1 1e-164 575 binding 6-(2,6-dibromophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine 159 K 161 K 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v58:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 1 1e-164 575 binding 6-(2,6-dibromophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine 201 E 203 E 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v58:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 1 1e-164 575 binding 6-(2,6-dibromophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine 203 Y 205 Y 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v58:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 1 1e-164 575 binding 6-(2,6-dibromophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine 204 L 206 L 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v58:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 1 1e-164 575 binding 6-(2,6-dibromophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine 209 H 211 H 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v58:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 1 1e-164 575 binding 6-(2,6-dibromophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine 233 Q 235 Q 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v58:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 1 1e-164 575 binding 6-(2,6-dibromophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine 236 H 238 Q 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v58:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 1 1e-164 575 binding 6-(2,6-dibromophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine 278 L 280 L 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) PDB 2v58:A 63.4 4 446 2 444 Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 1 1e-164 575 binding 6-(2,6-dibromophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine 437 I 439 I 19164768 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) SwissProt ACCC_ECOLI 63.4 4 446 2 444 Biotin carboxylase; Acetyl-coenzyme A carboxylase biotin carboxylase subunit A; EC 6.3.4.14 from Escherichia coli (strain K12) 1e-164 575 mutation to E: Loss of homodimerization. No effect on... 19 R 21 R 16793549 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) SwissProt ACCC_ECOLI 63.4 4 446 2 444 Biotin carboxylase; Acetyl-coenzyme A carboxylase biotin carboxylase subunit A; EC 6.3.4.14 from Escherichia coli (strain K12) 1e-164 575 mutation to R: Loss of homodimerization. No effect on... 23 E 25 Q 16793549 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) SwissProt ACCC_ECOLI 63.4 4 446 2 444 Biotin carboxylase; Acetyl-coenzyme A carboxylase biotin carboxylase subunit A; EC 6.3.4.14 from Escherichia coli (strain K12) 1e-164 575 binding 116 K 118 K 10821865,19213731 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) SwissProt ACCC_ECOLI 63.4 4 446 2 444 Biotin carboxylase; Acetyl-coenzyme A carboxylase biotin carboxylase subunit A; EC 6.3.4.14 from Escherichia coli (strain K12) 1e-164 575 binding 159 K 161 K 19213731 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) SwissProt ACCC_ECOLI 63.4 4 446 2 444 Biotin carboxylase; Acetyl-coenzyme A carboxylase biotin carboxylase subunit A; EC 6.3.4.14 from Escherichia coli (strain K12) 1e-164 575 binding 165..166 GG 167..168 GG 10821865,19213731 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) SwissProt ACCC_ECOLI 63.4 4 446 2 444 Biotin carboxylase; Acetyl-coenzyme A carboxylase biotin carboxylase subunit A; EC 6.3.4.14 from Escherichia coli (strain K12) 1e-164 575 binding 201..204 EKYL 203..206 EKYL 10821865,19213731 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) SwissProt ACCC_ECOLI 63.4 4 446 2 444 Biotin carboxylase; Acetyl-coenzyme A carboxylase biotin carboxylase subunit A; EC 6.3.4.14 from Escherichia coli (strain K12) 1e-164 575 binding 209 H 211 H 19213731 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) SwissProt ACCC_ECOLI 63.4 4 446 2 444 Biotin carboxylase; Acetyl-coenzyme A carboxylase biotin carboxylase subunit A; EC 6.3.4.14 from Escherichia coli (strain K12) 1e-164 575 binding 236 H 238 Q 10821865,19213731 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) SwissProt ACCC_ECOLI 63.4 4 446 2 444 Biotin carboxylase; Acetyl-coenzyme A carboxylase biotin carboxylase subunit A; EC 6.3.4.14 from Escherichia coli (strain K12) 1e-164 575 binding 238 K 240 K 19213731 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) SwissProt ACCC_ECOLI 63.4 4 446 2 444 Biotin carboxylase; Acetyl-coenzyme A carboxylase biotin carboxylase subunit A; EC 6.3.4.14 from Escherichia coli (strain K12) 1e-164 575 binding ; binding 276 E 278 E 19213731 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) SwissProt ACCC_ECOLI 63.4 4 446 2 444 Biotin carboxylase; Acetyl-coenzyme A carboxylase biotin carboxylase subunit A; EC 6.3.4.14 from Escherichia coli (strain K12) 1e-164 575 binding ; binding 288 E 290 E 10821865,19213731 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) SwissProt ACCC_ECOLI 63.4 4 446 2 444 Biotin carboxylase; Acetyl-coenzyme A carboxylase biotin carboxylase subunit A; EC 6.3.4.14 from Escherichia coli (strain K12) 1e-164 575 active site; binding 292 R 294 R 19213731 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) SwissProt ACCC_ECOLI 63.4 4 446 2 444 Biotin carboxylase; Acetyl-coenzyme A carboxylase biotin carboxylase subunit A; EC 6.3.4.14 from Escherichia coli (strain K12) 1e-164 575 binding 295 V 297 V 19213731 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) SwissProt ACCC_ECOLI 63.4 4 446 2 444 Biotin carboxylase; Acetyl-coenzyme A carboxylase biotin carboxylase subunit A; EC 6.3.4.14 from Escherichia coli (strain K12) 1e-164 575 mutation to A: Severe reduction in catalytic activity. 296 E 298 E 19213731 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) SwissProt ACCC_ECOLI 63.4 4 446 2 444 Biotin carboxylase; Acetyl-coenzyme A carboxylase biotin carboxylase subunit A; EC 6.3.4.14 from Escherichia coli (strain K12) 1e-164 575 binding ; binding ; mutation to A: Severe reduction in catalytic activity. 338 R 340 R 19213731 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) SwissProt ACCC_ECOLI 63.4 4 446 2 444 Biotin carboxylase; Acetyl-coenzyme A carboxylase biotin carboxylase subunit A; EC 6.3.4.14 from Escherichia coli (strain K12) 1e-164 575 mutation to A: Loss of homodimerization. No effect on... 363 F 365 L 16793549 5210939 Shew_3365 acetyl-CoA carboxylase, biotin carboxylase (RefSeq) SwissProt ACCC_ECOLI 63.4 4 446 2 444 Biotin carboxylase; Acetyl-coenzyme A carboxylase biotin carboxylase subunit A; EC 6.3.4.14 from Escherichia coli (strain K12) 1e-164 575 mutation to E: Loss of homodimerization. No effect on... 366 R 368 R 16793549