queryId subjectDb subjectId identity queryAlnBegin queryAlnEnd sujectAlnBegin subjectAlnEnd subjectDescription evalue bits subjectSite subjectSiteRange subjectSiteSeq querySiteRange querySiteSeq pubMedIds BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 5ti1:H 92.9 3 436 1 430 Crystal structure of fumarylacetoacetate hydrolase from burkholderia xenovorans lb400 0.0 831 active site 139 D 145 D BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 5ti1:H 92.9 3 436 1 430 Crystal structure of fumarylacetoacetate hydrolase from burkholderia xenovorans lb400 0.0 831 active site 146 H 152 H BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 5ti1:H 92.9 3 436 1 430 Crystal structure of fumarylacetoacetate hydrolase from burkholderia xenovorans lb400 0.0 831 active site 212 E 218 E BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 5ti1:H 92.9 3 436 1 430 Crystal structure of fumarylacetoacetate hydrolase from burkholderia xenovorans lb400 0.0 831 active site 214 E 220 E BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 5ti1:H 92.9 3 436 1 430 Crystal structure of fumarylacetoacetate hydrolase from burkholderia xenovorans lb400 0.0 831 active site 246 D 252 D BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 5ti1:H 92.9 3 436 1 430 Crystal structure of fumarylacetoacetate hydrolase from burkholderia xenovorans lb400 0.0 831 active site 250 R 256 R BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 5ti1:H 92.9 3 436 1 430 Crystal structure of fumarylacetoacetate hydrolase from burkholderia xenovorans lb400 0.0 831 active site 253 Q 259 Q BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 5ti1:H 92.9 3 436 1 430 Crystal structure of fumarylacetoacetate hydrolase from burkholderia xenovorans lb400 0.0 831 active site 266 K 272 K BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 5ti1:H 92.9 3 436 1 430 Crystal structure of fumarylacetoacetate hydrolase from burkholderia xenovorans lb400 0.0 831 active site 270 T 276 T BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 5ti1:H 92.9 3 436 1 430 Crystal structure of fumarylacetoacetate hydrolase from burkholderia xenovorans lb400 0.0 831 active site 377 E 383 E BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 5ti1:H 92.9 3 436 1 430 Crystal structure of fumarylacetoacetate hydrolase from burkholderia xenovorans lb400 0.0 831 binding magnesium ion 139 D 145 D BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 5ti1:H 92.9 3 436 1 430 Crystal structure of fumarylacetoacetate hydrolase from burkholderia xenovorans lb400 0.0 831 binding magnesium ion 212 E 218 E BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 5ti1:H 92.9 3 436 1 430 Crystal structure of fumarylacetoacetate hydrolase from burkholderia xenovorans lb400 0.0 831 binding magnesium ion 214 E 220 E BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 5ti1:H 92.9 3 436 1 430 Crystal structure of fumarylacetoacetate hydrolase from burkholderia xenovorans lb400 0.0 831 binding magnesium ion 246 D 252 D BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase SwissProt FAAA_MOUSE 57.5 17 435 2 416 Fumarylacetoacetase; FAA; Beta-diketonase; Fumarylacetoacetate hydrolase; EC 3.7.1.2 from Mus musculus (Mouse) 1e-145 511 binding 126 D 145 D 10508789,11154690 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase SwissProt FAAA_MOUSE 57.5 17 435 2 416 Fumarylacetoacetase; FAA; Beta-diketonase; Fumarylacetoacetate hydrolase; EC 3.7.1.2 from Mus musculus (Mouse) 1e-145 511 binding 199 E 218 E 10508789,11154690 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase SwissProt FAAA_MOUSE 57.5 17 435 2 416 Fumarylacetoacetase; FAA; Beta-diketonase; Fumarylacetoacetate hydrolase; EC 3.7.1.2 from Mus musculus (Mouse) 1e-145 511 binding ; mutation to G: Decrease in activity. 201 E 220 E 10508789,11154690,11209059 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase SwissProt FAAA_MOUSE 57.5 17 435 2 416 Fumarylacetoacetase; FAA; Beta-diketonase; Fumarylacetoacetate hydrolase; EC 3.7.1.2 from Mus musculus (Mouse) 1e-145 511 binding ; binding 233 D 252 D 10508789,11154690 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase SwissProt FAAA_MOUSE 57.5 17 435 2 416 Fumarylacetoacetase; FAA; Beta-diketonase; Fumarylacetoacetate hydrolase; EC 3.7.1.2 from Mus musculus (Mouse) 1e-145 511 binding 253 K 272 K 11154690 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase SwissProt FAAA_MOUSE 57.5 17 435 2 416 Fumarylacetoacetase; FAA; Beta-diketonase; Fumarylacetoacetate hydrolase; EC 3.7.1.2 from Mus musculus (Mouse) 1e-145 511 binding 257 T 276 T 11154690 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase SwissProt FAAA_HUMAN 57.0 17 435 2 416 Fumarylacetoacetase; FAA; Beta-diketonase; Fumarylacetoacetate hydrolase; EC 3.7.1.2 from Homo sapiens (Human) 1e-144 511 modified: N-acetylserine 2 S 17 S BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase SwissProt FAAA_HUMAN 57.0 17 435 2 416 Fumarylacetoacetase; FAA; Beta-diketonase; Fumarylacetoacetate hydrolase; EC 3.7.1.2 from Homo sapiens (Human) 1e-144 511 to I: in TYRSN1; loss of activity; dbSNP:rs121965073 16 N 33 N 11278491,1401056 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase SwissProt FAAA_HUMAN 57.0 17 435 2 416 Fumarylacetoacetase; FAA; Beta-diketonase; Fumarylacetoacetate hydrolase; EC 3.7.1.2 from Homo sapiens (Human) 1e-144 511 to T: in TYRSN1; atypical mild phenotype 35 A 52 A 20003495 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase SwissProt FAAA_HUMAN 57.0 17 435 2 416 Fumarylacetoacetase; FAA; Beta-diketonase; Fumarylacetoacetate hydrolase; EC 3.7.1.2 from Homo sapiens (Human) 1e-144 511 to C: in TYRSN1; loss of activity 62 F 81 F 11278491 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase SwissProt FAAA_HUMAN 57.0 17 435 2 416 Fumarylacetoacetase; FAA; Beta-diketonase; Fumarylacetoacetate hydrolase; EC 3.7.1.2 from Homo sapiens (Human) 1e-144 511 to D: in TYRSN1; loss of activity; dbSNP:rs121965074 134 A 153 A 11278491,8005583,8364576 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase SwissProt FAAA_HUMAN 57.0 17 435 2 416 Fumarylacetoacetase; FAA; Beta-diketonase; Fumarylacetoacetate hydrolase; EC 3.7.1.2 from Homo sapiens (Human) 1e-144 511 to R: in TYRSN1; loss of activity 193 C 212 C 11278491,8557261 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase SwissProt FAAA_HUMAN 57.0 17 435 2 416 Fumarylacetoacetase; FAA; Beta-diketonase; Fumarylacetoacetate hydrolase; EC 3.7.1.2 from Homo sapiens (Human) 1e-144 511 to V: in TYRSN1; loss of activity; dbSNP:rs80338897 233 D 252 D 11278491,7942842 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase SwissProt FAAA_HUMAN 57.0 17 435 2 416 Fumarylacetoacetase; FAA; Beta-diketonase; Fumarylacetoacetate hydrolase; EC 3.7.1.2 from Homo sapiens (Human) 1e-144 511 to G: in TYRSN1; loss of activity; dbSNP:rs1555441595 234 W 253 W 11278491,7550234 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase SwissProt FAAA_HUMAN 57.0 17 435 2 416 Fumarylacetoacetase; FAA; Beta-diketonase; Fumarylacetoacetate hydrolase; EC 3.7.1.2 from Homo sapiens (Human) 1e-144 511 to R: in TYRSN1; may affect splicing resulting in... 279 Q 298 Q 11196105,11278491,11476670 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase SwissProt FAAA_HUMAN 57.0 17 435 2 416 Fumarylacetoacetase; FAA; Beta-diketonase; Fumarylacetoacetate hydrolase; EC 3.7.1.2 from Homo sapiens (Human) 1e-144 511 to W: does not cause a clinically relevant phenotype;... 341 R 360 R 11278491,27535533,7977370 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase SwissProt FAAA_HUMAN 57.0 17 435 2 416 Fumarylacetoacetase; FAA; Beta-diketonase; Fumarylacetoacetate hydrolase; EC 3.7.1.2 from Homo sapiens (Human) 1e-144 511 to L: in TYRSN1; loss of activity; dbSNP:rs779040832 342 P 361 V 8005583 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase SwissProt FAAA_HUMAN 57.0 17 435 2 416 Fumarylacetoacetase; FAA; Beta-diketonase; Fumarylacetoacetate hydrolase; EC 3.7.1.2 from Homo sapiens (Human) 1e-144 511 to G: in TYRSN1; loss of activity; dbSNP:rs121965077 381 R 400 R 7757089 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase SwissProt FAAA_HUMAN 57.0 17 435 2 416 Fumarylacetoacetase; FAA; Beta-diketonase; Fumarylacetoacetate hydrolase; EC 3.7.1.2 from Homo sapiens (Human) 1e-144 511 to H: in TYRSN1; requires 2 nucleotide substitutions 405 F 424 F 9633815 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase SwissProt FAAA_HUMAN 57.0 17 435 2 416 Fumarylacetoacetase; FAA; Beta-diketonase; Fumarylacetoacetate hydrolase; EC 3.7.1.2 from Homo sapiens (Human) 1e-144 511 modified: Initiator methionine, Removed 1 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 1hyo:B 57.5 17 435 4 418 Crystal structure of fumarylacetoacetate hydrolase complexed with 4- (hydroxymethylphosphinoyl)-3-oxo-butanoic acid 1e-144 510 active site 128 D 145 D 11154690 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 1hyo:B 57.5 17 435 4 418 Crystal structure of fumarylacetoacetate hydrolase complexed with 4- (hydroxymethylphosphinoyl)-3-oxo-butanoic acid 1e-144 510 active site 135 H 152 H 11154690 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 1hyo:B 57.5 17 435 4 418 Crystal structure of fumarylacetoacetate hydrolase complexed with 4- (hydroxymethylphosphinoyl)-3-oxo-butanoic acid 1e-144 510 active site 201 E 218 E 11154690 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 1hyo:B 57.5 17 435 4 418 Crystal structure of fumarylacetoacetate hydrolase complexed with 4- (hydroxymethylphosphinoyl)-3-oxo-butanoic acid 1e-144 510 active site 203 E 220 E 11154690 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 1hyo:B 57.5 17 435 4 418 Crystal structure of fumarylacetoacetate hydrolase complexed with 4- (hydroxymethylphosphinoyl)-3-oxo-butanoic acid 1e-144 510 active site 235 D 252 D 11154690 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 1hyo:B 57.5 17 435 4 418 Crystal structure of fumarylacetoacetate hydrolase complexed with 4- (hydroxymethylphosphinoyl)-3-oxo-butanoic acid 1e-144 510 active site 239 R 256 R 11154690 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 1hyo:B 57.5 17 435 4 418 Crystal structure of fumarylacetoacetate hydrolase complexed with 4- (hydroxymethylphosphinoyl)-3-oxo-butanoic acid 1e-144 510 active site 242 Q 259 Q 11154690 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 1hyo:B 57.5 17 435 4 418 Crystal structure of fumarylacetoacetate hydrolase complexed with 4- (hydroxymethylphosphinoyl)-3-oxo-butanoic acid 1e-144 510 active site 255 K 272 K 11154690 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 1hyo:B 57.5 17 435 4 418 Crystal structure of fumarylacetoacetate hydrolase complexed with 4- (hydroxymethylphosphinoyl)-3-oxo-butanoic acid 1e-144 510 active site 259 T 276 T 11154690 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 1hyo:B 57.5 17 435 4 418 Crystal structure of fumarylacetoacetate hydrolase complexed with 4- (hydroxymethylphosphinoyl)-3-oxo-butanoic acid 1e-144 510 active site 366 E 383 E 11154690 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 1hyo:B 57.5 17 435 4 418 Crystal structure of fumarylacetoacetate hydrolase complexed with 4- (hydroxymethylphosphinoyl)-3-oxo-butanoic acid 1e-144 510 binding acetate ion 130 Y 147 Y 11154690 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 1hyo:B 57.5 17 435 4 418 Crystal structure of fumarylacetoacetate hydrolase complexed with 4- (hydroxymethylphosphinoyl)-3-oxo-butanoic acid 1e-144 510 binding acetate ion 139 V 156 V 11154690 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 1hyo:B 57.5 17 435 4 418 Crystal structure of fumarylacetoacetate hydrolase complexed with 4- (hydroxymethylphosphinoyl)-3-oxo-butanoic acid 1e-144 510 binding acetate ion 144 R 161 R 11154690 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 1hyo:B 57.5 17 435 4 418 Crystal structure of fumarylacetoacetate hydrolase complexed with 4- (hydroxymethylphosphinoyl)-3-oxo-butanoic acid 1e-144 510 binding calcium ion 128 D 145 D 11154690 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 1hyo:B 57.5 17 435 4 418 Crystal structure of fumarylacetoacetate hydrolase complexed with 4- (hydroxymethylphosphinoyl)-3-oxo-butanoic acid 1e-144 510 binding calcium ion 201 E 218 E 11154690 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 1hyo:B 57.5 17 435 4 418 Crystal structure of fumarylacetoacetate hydrolase complexed with 4- (hydroxymethylphosphinoyl)-3-oxo-butanoic acid 1e-144 510 binding calcium ion 203 E 220 E 11154690 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 1hyo:B 57.5 17 435 4 418 Crystal structure of fumarylacetoacetate hydrolase complexed with 4- (hydroxymethylphosphinoyl)-3-oxo-butanoic acid 1e-144 510 binding calcium ion 235 D 252 D 11154690 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 1hyo:B 57.5 17 435 4 418 Crystal structure of fumarylacetoacetate hydrolase complexed with 4- (hydroxymethylphosphinoyl)-3-oxo-butanoic acid 1e-144 510 binding 4-[hydroxy-[methyl-phosphinoyl]]-3-oxo-butanoic acid 128 D 145 D 11154690 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 1hyo:B 57.5 17 435 4 418 Crystal structure of fumarylacetoacetate hydrolase complexed with 4- (hydroxymethylphosphinoyl)-3-oxo-butanoic acid 1e-144 510 binding 4-[hydroxy-[methyl-phosphinoyl]]-3-oxo-butanoic acid 129 F 146 F 11154690 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 1hyo:B 57.5 17 435 4 418 Crystal structure of fumarylacetoacetate hydrolase complexed with 4- (hydroxymethylphosphinoyl)-3-oxo-butanoic acid 1e-144 510 binding 4-[hydroxy-[methyl-phosphinoyl]]-3-oxo-butanoic acid 130 Y 147 Y 11154690 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 1hyo:B 57.5 17 435 4 418 Crystal structure of fumarylacetoacetate hydrolase complexed with 4- (hydroxymethylphosphinoyl)-3-oxo-butanoic acid 1e-144 510 binding 4-[hydroxy-[methyl-phosphinoyl]]-3-oxo-butanoic acid 135 H 152 H 11154690 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 1hyo:B 57.5 17 435 4 418 Crystal structure of fumarylacetoacetate hydrolase complexed with 4- (hydroxymethylphosphinoyl)-3-oxo-butanoic acid 1e-144 510 binding 4-[hydroxy-[methyl-phosphinoyl]]-3-oxo-butanoic acid 161 Y 178 Y 11154690 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 1hyo:B 57.5 17 435 4 418 Crystal structure of fumarylacetoacetate hydrolase complexed with 4- (hydroxymethylphosphinoyl)-3-oxo-butanoic acid 1e-144 510 binding 4-[hydroxy-[methyl-phosphinoyl]]-3-oxo-butanoic acid 255 K 272 K 11154690 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 1hyo:B 57.5 17 435 4 418 Crystal structure of fumarylacetoacetate hydrolase complexed with 4- (hydroxymethylphosphinoyl)-3-oxo-butanoic acid 1e-144 510 binding 4-[hydroxy-[methyl-phosphinoyl]]-3-oxo-butanoic acid 351 G 368 G 11154690 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 1hyo:B 57.5 17 435 4 418 Crystal structure of fumarylacetoacetate hydrolase complexed with 4- (hydroxymethylphosphinoyl)-3-oxo-butanoic acid 1e-144 510 binding 4-[hydroxy-[methyl-phosphinoyl]]-3-oxo-butanoic acid 352 T 369 T 11154690 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 1hyo:B 57.5 17 435 4 418 Crystal structure of fumarylacetoacetate hydrolase complexed with 4- (hydroxymethylphosphinoyl)-3-oxo-butanoic acid 1e-144 510 binding magnesium ion 235 D 252 D 11154690 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 1hyo:B 57.5 17 435 4 418 Crystal structure of fumarylacetoacetate hydrolase complexed with 4- (hydroxymethylphosphinoyl)-3-oxo-butanoic acid 1e-144 510 binding magnesium ion 236 W 253 W 11154690 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 1hyo:B 57.5 17 435 4 418 Crystal structure of fumarylacetoacetate hydrolase complexed with 4- (hydroxymethylphosphinoyl)-3-oxo-butanoic acid 1e-144 510 binding magnesium ion 255 K 272 K 11154690 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 1hyo:B 57.5 17 435 4 418 Crystal structure of fumarylacetoacetate hydrolase complexed with 4- (hydroxymethylphosphinoyl)-3-oxo-butanoic acid 1e-144 510 binding magnesium ion 258 G 275 A 11154690 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 1hyo:B 57.5 17 435 4 418 Crystal structure of fumarylacetoacetate hydrolase complexed with 4- (hydroxymethylphosphinoyl)-3-oxo-butanoic acid 1e-144 510 binding magnesium ion 259 T 276 T 11154690 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 2hzy:A 57.5 17 435 2 416 Mouse fumarylacetoacetate hydrolase complexes with a transition-state mimic of the complete substrate 1e-144 510 active site 126 D 145 D 17064256 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 2hzy:A 57.5 17 435 2 416 Mouse fumarylacetoacetate hydrolase complexes with a transition-state mimic of the complete substrate 1e-144 510 active site 133 H 152 H 17064256 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 2hzy:A 57.5 17 435 2 416 Mouse fumarylacetoacetate hydrolase complexes with a transition-state mimic of the complete substrate 1e-144 510 active site 199 E 218 E 17064256 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 2hzy:A 57.5 17 435 2 416 Mouse fumarylacetoacetate hydrolase complexes with a transition-state mimic of the complete substrate 1e-144 510 active site 201 E 220 E 17064256 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 2hzy:A 57.5 17 435 2 416 Mouse fumarylacetoacetate hydrolase complexes with a transition-state mimic of the complete substrate 1e-144 510 active site 233 D 252 D 17064256 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 2hzy:A 57.5 17 435 2 416 Mouse fumarylacetoacetate hydrolase complexes with a transition-state mimic of the complete substrate 1e-144 510 active site 237 R 256 R 17064256 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 2hzy:A 57.5 17 435 2 416 Mouse fumarylacetoacetate hydrolase complexes with a transition-state mimic of the complete substrate 1e-144 510 active site 240 Q 259 Q 17064256 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 2hzy:A 57.5 17 435 2 416 Mouse fumarylacetoacetate hydrolase complexes with a transition-state mimic of the complete substrate 1e-144 510 active site 253 K 272 K 17064256 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 2hzy:A 57.5 17 435 2 416 Mouse fumarylacetoacetate hydrolase complexes with a transition-state mimic of the complete substrate 1e-144 510 active site 257 T 276 T 17064256 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 2hzy:A 57.5 17 435 2 416 Mouse fumarylacetoacetate hydrolase complexes with a transition-state mimic of the complete substrate 1e-144 510 active site 364 E 383 E 17064256 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 2hzy:A 57.5 17 435 2 416 Mouse fumarylacetoacetate hydrolase complexes with a transition-state mimic of the complete substrate 1e-144 510 binding calcium ion 122 G 141 P 17064256 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 2hzy:A 57.5 17 435 2 416 Mouse fumarylacetoacetate hydrolase complexes with a transition-state mimic of the complete substrate 1e-144 510 binding calcium ion 123 D 142 G 17064256 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 2hzy:A 57.5 17 435 2 416 Mouse fumarylacetoacetate hydrolase complexes with a transition-state mimic of the complete substrate 1e-144 510 binding manganese (ii) ion 126 D 145 D 17064256 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 2hzy:A 57.5 17 435 2 416 Mouse fumarylacetoacetate hydrolase complexes with a transition-state mimic of the complete substrate 1e-144 510 binding manganese (ii) ion 199 E 218 E 17064256 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 2hzy:A 57.5 17 435 2 416 Mouse fumarylacetoacetate hydrolase complexes with a transition-state mimic of the complete substrate 1e-144 510 binding manganese (ii) ion 201 E 220 E 17064256 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 2hzy:A 57.5 17 435 2 416 Mouse fumarylacetoacetate hydrolase complexes with a transition-state mimic of the complete substrate 1e-144 510 binding manganese (ii) ion 233 D 252 D 17064256 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 1qco:A 57.5 17 435 2 416 Crystal structure of fumarylacetoacetate hydrolase complexed with fumarate and acetoacetate 1e-144 510 active site 253 K 272 K 10508789 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 1qco:A 57.5 17 435 2 416 Crystal structure of fumarylacetoacetate hydrolase complexed with fumarate and acetoacetate 1e-144 510 binding acetoacetic acid 126 D 145 D 10508789 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 1qco:A 57.5 17 435 2 416 Crystal structure of fumarylacetoacetate hydrolase complexed with fumarate and acetoacetate 1e-144 510 binding acetoacetic acid 127 F 146 F 10508789 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 1qco:A 57.5 17 435 2 416 Crystal structure of fumarylacetoacetate hydrolase complexed with fumarate and acetoacetate 1e-144 510 binding acetoacetic acid 128 Y 147 Y 10508789 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 1qco:A 57.5 17 435 2 416 Crystal structure of fumarylacetoacetate hydrolase complexed with fumarate and acetoacetate 1e-144 510 binding acetoacetic acid 133 H 152 H 10508789 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 1qco:A 57.5 17 435 2 416 Crystal structure of fumarylacetoacetate hydrolase complexed with fumarate and acetoacetate 1e-144 510 binding acetoacetic acid 159 Y 178 Y 10508789 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 1qco:A 57.5 17 435 2 416 Crystal structure of fumarylacetoacetate hydrolase complexed with fumarate and acetoacetate 1e-144 510 binding acetoacetic acid 199 E 218 E 10508789 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 1qco:A 57.5 17 435 2 416 Crystal structure of fumarylacetoacetate hydrolase complexed with fumarate and acetoacetate 1e-144 510 binding acetoacetic acid 253 K 272 K 10508789 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 1qco:A 57.5 17 435 2 416 Crystal structure of fumarylacetoacetate hydrolase complexed with fumarate and acetoacetate 1e-144 510 binding acetoacetic acid 349 G 368 G 10508789 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 1qco:A 57.5 17 435 2 416 Crystal structure of fumarylacetoacetate hydrolase complexed with fumarate and acetoacetate 1e-144 510 binding acetoacetic acid 350 T 369 T 10508789 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 1qco:A 57.5 17 435 2 416 Crystal structure of fumarylacetoacetate hydrolase complexed with fumarate and acetoacetate 1e-144 510 binding calcium ion 126 D 145 D 10508789 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 1qco:A 57.5 17 435 2 416 Crystal structure of fumarylacetoacetate hydrolase complexed with fumarate and acetoacetate 1e-144 510 binding calcium ion 199 E 218 E 10508789 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 1qco:A 57.5 17 435 2 416 Crystal structure of fumarylacetoacetate hydrolase complexed with fumarate and acetoacetate 1e-144 510 binding calcium ion 201 E 220 E 10508789 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 1qco:A 57.5 17 435 2 416 Crystal structure of fumarylacetoacetate hydrolase complexed with fumarate and acetoacetate 1e-144 510 binding calcium ion 233 D 252 D 10508789 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 1qco:A 57.5 17 435 2 416 Crystal structure of fumarylacetoacetate hydrolase complexed with fumarate and acetoacetate 1e-144 510 binding fumaric acid 128 Y 147 Y 10508789 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 1qco:A 57.5 17 435 2 416 Crystal structure of fumarylacetoacetate hydrolase complexed with fumarate and acetoacetate 1e-144 510 binding fumaric acid 137 V 156 V 10508789 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 1qco:A 57.5 17 435 2 416 Crystal structure of fumarylacetoacetate hydrolase complexed with fumarate and acetoacetate 1e-144 510 binding fumaric acid 142 R 161 R 10508789 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 1qco:A 57.5 17 435 2 416 Crystal structure of fumarylacetoacetate hydrolase complexed with fumarate and acetoacetate 1e-144 510 binding fumaric acid 240 Q 259 Q 10508789 BPHYT_RS03805 BPHYT_RS03805 fumarylacetoacetase PDB 1qco:A 57.5 17 435 2 416 Crystal structure of fumarylacetoacetate hydrolase complexed with fumarate and acetoacetate 1e-144 510 binding fumaric acid 244 Y 263 Y 10508789