queryId subjectDb subjectId identity queryAlnBegin queryAlnEnd sujectAlnBegin subjectAlnEnd subjectDescription evalue bits subjectSite subjectSiteRange subjectSiteSeq querySiteRange querySiteSeq pubMedIds CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit SwissProt LEUC_SCHPO 55.0 3 468 9 482 3-isopropylmalate dehydratase; Alpha-IPM isomerase; IPMI; Isopropylmalate isomerase; EC 4.2.1.33 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 1e-144 510 modified: Phosphoserine 486 18257517 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit SwissProt LEUC_SCHPO 55.0 3 468 9 482 3-isopropylmalate dehydratase; Alpha-IPM isomerase; IPMI; Isopropylmalate isomerase; EC 4.2.1.33 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 1e-144 510 modified: Phosphoserine 488 18257517 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 4kp1:A 34.7 4 464 3 423 Crystal structure of ipm isomerase large subunit from methanococcus jannaschii (mj0499) 1e-63 242 active site 64 D 62 D 24699638 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 4kp1:A 34.7 4 464 3 423 Crystal structure of ipm isomerase large subunit from methanococcus jannaschii (mj0499) 1e-63 242 active site 65 H 63 H 24699638 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 4kp1:A 34.7 4 464 3 423 Crystal structure of ipm isomerase large subunit from methanococcus jannaschii (mj0499) 1e-63 242 active site 121 D 128 D 24699638 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 4kp1:A 34.7 4 464 3 423 Crystal structure of ipm isomerase large subunit from methanococcus jannaschii (mj0499) 1e-63 242 active site 387 R 429 R 24699638 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 4kp1:A 34.7 4 464 3 423 Crystal structure of ipm isomerase large subunit from methanococcus jannaschii (mj0499) 1e-63 242 binding 2,4-dimethylpentane-2,4-diol 299 F 342 F 24699638 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 4kp1:A 34.7 4 464 3 423 Crystal structure of ipm isomerase large subunit from methanococcus jannaschii (mj0499) 1e-63 242 binding 2,4-dimethylpentane-2,4-diol 302 S 345 S 24699638 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 4kp1:A 34.7 4 464 3 423 Crystal structure of ipm isomerase large subunit from methanococcus jannaschii (mj0499) 1e-63 242 binding 2,4-dimethylpentane-2,4-diol 383 S 425 S 24699638 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 4kp1:A 34.7 4 464 3 423 Crystal structure of ipm isomerase large subunit from methanococcus jannaschii (mj0499) 1e-63 242 binding 2,4-dimethylpentane-2,4-diol 389 F 431 F 24699638 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 4kp1:A 34.7 4 464 3 423 Crystal structure of ipm isomerase large subunit from methanococcus jannaschii (mj0499) 1e-63 242 binding magnesium ion 303 C 346 C 24699638 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 4kp1:A 34.7 4 464 3 423 Crystal structure of ipm isomerase large subunit from methanococcus jannaschii (mj0499) 1e-63 242 binding magnesium ion 304 T 347 T 24699638 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 4kp1:A 34.7 4 464 3 423 Crystal structure of ipm isomerase large subunit from methanococcus jannaschii (mj0499) 1e-63 242 binding magnesium ion 387 R 429 R 24699638 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 4nqy:A 34.2 4 463 2 409 The reduced form of mj0499 2e-61 234 active site 63 D 62 D 24699638 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 4nqy:A 34.2 4 463 2 409 The reduced form of mj0499 2e-61 234 active site 108 D 128 D 24699638 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 4nqy:A 34.2 4 463 2 409 The reduced form of mj0499 2e-61 234 active site 374 R 429 R 24699638 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 4nqy:A 34.2 4 463 2 409 The reduced form of mj0499 2e-61 234 binding zinc ion 351 C 406 C 24699638 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 4nqy:A 34.2 4 463 2 409 The reduced form of mj0499 2e-61 234 binding zinc ion 354 C 409 C 24699638 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit SwissProt ACON2_YEAST 28.5 72 456 137 505 Homocitrate dehydratase, mitochondrial; Aconitase 2; EC 4.2.1.- from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 9e-35 146 K→R: Reduces catalytic activity towards homoaconitate by 45% and... 610 23106124 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit SwissProt ACON_YEAST 29.3 77 469 141 512 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 3e-31 134 modified: transit peptide, Mitochondrion 1..16 15975908 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit SwissProt ACON_YEAST 29.3 77 469 141 512 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 3e-31 134 R→K: Strongly diminishes the catalytic activity towards both known... 604 23106124 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit SwissProt ACON_PIG 26.5 76 458 144 505 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Sus scrofa (Pig) 7e-23 107 binding 192..194 DSH 128..130 DSH 10631981 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit SwissProt ACON_PIG 26.5 76 458 144 505 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Sus scrofa (Pig) 7e-23 107 binding 385 C 346 C 10631981,2726740 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit SwissProt ACON_PIG 26.5 76 458 144 505 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Sus scrofa (Pig) 7e-23 107 binding 448 C 406 C 10631981,2726740 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit SwissProt ACON_PIG 26.5 76 458 144 505 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Sus scrofa (Pig) 7e-23 107 binding 451 C 409 C 10631981,2726740 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit SwissProt ACON_PIG 26.5 76 458 144 505 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Sus scrofa (Pig) 7e-23 107 binding 474 R 429 R 10631981 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit SwissProt ACON_PIG 26.5 76 458 144 505 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Sus scrofa (Pig) 7e-23 107 binding 479 R 434 R 10631981 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit SwissProt ACON_PIG 26.5 76 458 144 505 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Sus scrofa (Pig) 7e-23 107 modified: Pyrrolidone carboxylic acid 28 2303429 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit SwissProt ACON_PIG 26.5 76 458 144 505 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Sus scrofa (Pig) 7e-23 107 binding 99 10631981 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit SwissProt ACON_PIG 26.5 76 458 144 505 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Sus scrofa (Pig) 7e-23 107 binding 607 10631981 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit SwissProt ACON_PIG 26.5 76 458 144 505 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Sus scrofa (Pig) 7e-23 107 binding 670..671 10631981 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit SwissProt ACON_BOVIN 26.5 76 458 144 505 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Bos taurus (Bovine) 8e-23 107 binding 192..194 DSH 128..130 DSH 1547214 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit SwissProt ACON_BOVIN 26.5 76 458 144 505 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Bos taurus (Bovine) 8e-23 107 binding 385 C 346 C 1547214,3372519 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit SwissProt ACON_BOVIN 26.5 76 458 144 505 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Bos taurus (Bovine) 8e-23 107 binding 448 C 406 C 1547214,3372519 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit SwissProt ACON_BOVIN 26.5 76 458 144 505 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Bos taurus (Bovine) 8e-23 107 binding 451 C 409 C 1547214,3372519 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit SwissProt ACON_BOVIN 26.5 76 458 144 505 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Bos taurus (Bovine) 8e-23 107 binding 474 R 429 R 1547214 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit SwissProt ACON_BOVIN 26.5 76 458 144 505 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Bos taurus (Bovine) 8e-23 107 binding 479 R 434 R 1547214 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit SwissProt ACON_BOVIN 26.5 76 458 144 505 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Bos taurus (Bovine) 8e-23 107 binding 99 1547214 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit SwissProt ACON_BOVIN 26.5 76 458 144 505 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Bos taurus (Bovine) 8e-23 107 binding 607 1547214 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit SwissProt ACON_BOVIN 26.5 76 458 144 505 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Bos taurus (Bovine) 8e-23 107 binding 670..671 1547214 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1b0k:A 26.5 76 458 116 477 S642a:fluorocitrate complex of aconitase 8e-23 107 active site 164 D 128 D 10631981 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1b0k:A 26.5 76 458 116 477 S642a:fluorocitrate complex of aconitase 8e-23 107 active site 446 R 429 R 10631981 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1b0k:A 26.5 76 458 116 477 S642a:fluorocitrate complex of aconitase 8e-23 107 binding citrate anion 164 D 128 D 10631981 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1b0k:A 26.5 76 458 116 477 S642a:fluorocitrate complex of aconitase 8e-23 107 binding citrate anion 165 S 129 S 10631981 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1b0k:A 26.5 76 458 116 477 S642a:fluorocitrate complex of aconitase 8e-23 107 binding citrate anion 446 R 429 R 10631981 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1b0k:A 26.5 76 458 116 477 S642a:fluorocitrate complex of aconitase 8e-23 107 binding citrate anion 451 R 434 R 10631981 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1b0k:A 26.5 76 458 116 477 S642a:fluorocitrate complex of aconitase 8e-23 107 binding oxygen atom 164 D 128 D 10631981 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1b0k:A 26.5 76 458 116 477 S642a:fluorocitrate complex of aconitase 8e-23 107 binding oxygen atom 166 H 130 H 10631981 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1b0k:A 26.5 76 458 116 477 S642a:fluorocitrate complex of aconitase 8e-23 107 binding iron/sulfur cluster 164 D 128 D 10631981 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1b0k:A 26.5 76 458 116 477 S642a:fluorocitrate complex of aconitase 8e-23 107 binding iron/sulfur cluster 166 H 130 H 10631981 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1b0k:A 26.5 76 458 116 477 S642a:fluorocitrate complex of aconitase 8e-23 107 binding iron/sulfur cluster 356 S 345 S 10631981 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1b0k:A 26.5 76 458 116 477 S642a:fluorocitrate complex of aconitase 8e-23 107 binding iron/sulfur cluster 357 C 346 C 10631981 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1b0k:A 26.5 76 458 116 477 S642a:fluorocitrate complex of aconitase 8e-23 107 binding iron/sulfur cluster 420 C 406 C 10631981 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1b0k:A 26.5 76 458 116 477 S642a:fluorocitrate complex of aconitase 8e-23 107 binding iron/sulfur cluster 423 C 409 C 10631981 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1b0k:A 26.5 76 458 116 477 S642a:fluorocitrate complex of aconitase 8e-23 107 active site 99 10631981 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1b0k:A 26.5 76 458 116 477 S642a:fluorocitrate complex of aconitase 8e-23 107 active site 100 10631981 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1b0k:A 26.5 76 458 116 477 S642a:fluorocitrate complex of aconitase 8e-23 107 active site 641 10631981 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1b0k:A 26.5 76 458 116 477 S642a:fluorocitrate complex of aconitase 8e-23 107 active site 643 10631981 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1b0k:A 26.5 76 458 116 477 S642a:fluorocitrate complex of aconitase 8e-23 107 binding citrate anion 71 10631981 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1b0k:A 26.5 76 458 116 477 S642a:fluorocitrate complex of aconitase 8e-23 107 binding citrate anion 100 10631981 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1b0k:A 26.5 76 458 116 477 S642a:fluorocitrate complex of aconitase 8e-23 107 binding citrate anion 579 10631981 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1b0k:A 26.5 76 458 116 477 S642a:fluorocitrate complex of aconitase 8e-23 107 binding citrate anion 641 10631981 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1b0k:A 26.5 76 458 116 477 S642a:fluorocitrate complex of aconitase 8e-23 107 binding citrate anion 642 10631981 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1b0k:A 26.5 76 458 116 477 S642a:fluorocitrate complex of aconitase 8e-23 107 binding citrate anion 643 10631981 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1b0k:A 26.5 76 458 116 477 S642a:fluorocitrate complex of aconitase 8e-23 107 binding iron/sulfur cluster 100 10631981 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 5acn:A 26.5 76 458 117 478 Structure of activated aconitase. Formation of the (4fe-4s) cluster in the crystal 9e-23 106 active site 165 D 128 D 2726740 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 5acn:A 26.5 76 458 117 478 Structure of activated aconitase. Formation of the (4fe-4s) cluster in the crystal 9e-23 106 active site 447 R 429 R 2726740 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 5acn:A 26.5 76 458 117 478 Structure of activated aconitase. Formation of the (4fe-4s) cluster in the crystal 9e-23 106 binding fe3-s4 cluster 145 I 107 I 2726740 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 5acn:A 26.5 76 458 117 478 Structure of activated aconitase. Formation of the (4fe-4s) cluster in the crystal 9e-23 106 binding fe3-s4 cluster 147 H 109 H 2726740 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 5acn:A 26.5 76 458 117 478 Structure of activated aconitase. Formation of the (4fe-4s) cluster in the crystal 9e-23 106 binding fe3-s4 cluster 167 H 130 H 2726740 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 5acn:A 26.5 76 458 117 478 Structure of activated aconitase. Formation of the (4fe-4s) cluster in the crystal 9e-23 106 binding fe3-s4 cluster 358 C 346 C 2726740 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 5acn:A 26.5 76 458 117 478 Structure of activated aconitase. Formation of the (4fe-4s) cluster in the crystal 9e-23 106 binding fe3-s4 cluster 421 C 406 C 2726740 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 5acn:A 26.5 76 458 117 478 Structure of activated aconitase. Formation of the (4fe-4s) cluster in the crystal 9e-23 106 binding fe3-s4 cluster 424 C 409 C 2726740 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 5acn:A 26.5 76 458 117 478 Structure of activated aconitase. Formation of the (4fe-4s) cluster in the crystal 9e-23 106 binding fe3-s4 cluster 446 N 428 N 2726740 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 5acn:A 26.5 76 458 117 478 Structure of activated aconitase. Formation of the (4fe-4s) cluster in the crystal 9e-23 106 binding tricarballylic acid 198 K 161 S 2726740 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 5acn:A 26.5 76 458 117 478 Structure of activated aconitase. Formation of the (4fe-4s) cluster in the crystal 9e-23 106 binding tricarballylic acid 235 G 198 G 2726740 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 5acn:A 26.5 76 458 117 478 Structure of activated aconitase. Formation of the (4fe-4s) cluster in the crystal 9e-23 106 active site 100 2726740 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 5acn:A 26.5 76 458 117 478 Structure of activated aconitase. Formation of the (4fe-4s) cluster in the crystal 9e-23 106 active site 101 2726740 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 5acn:A 26.5 76 458 117 478 Structure of activated aconitase. Formation of the (4fe-4s) cluster in the crystal 9e-23 106 active site 642 2726740 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 5acn:A 26.5 76 458 117 478 Structure of activated aconitase. Formation of the (4fe-4s) cluster in the crystal 9e-23 106 active site 644 2726740 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 5acn:A 26.5 76 458 117 478 Structure of activated aconitase. Formation of the (4fe-4s) cluster in the crystal 9e-23 106 binding tricarballylic acid 666 2726740 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 8acn:A 26.2 76 458 116 477 Crystal structures of aconitase with isocitrate and nitroisocitrate bound 1e-22 106 active site 164 D 128 D 1547214 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 8acn:A 26.2 76 458 116 477 Crystal structures of aconitase with isocitrate and nitroisocitrate bound 1e-22 106 active site 446 R 429 R 1547214 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 8acn:A 26.2 76 458 116 477 Crystal structures of aconitase with isocitrate and nitroisocitrate bound 1e-22 106 binding nitroisocitric acid 164 D 128 D 1547214 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 8acn:A 26.2 76 458 116 477 Crystal structures of aconitase with isocitrate and nitroisocitrate bound 1e-22 106 binding nitroisocitric acid 165 S 129 S 1547214 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 8acn:A 26.2 76 458 116 477 Crystal structures of aconitase with isocitrate and nitroisocitrate bound 1e-22 106 binding nitroisocitric acid 446 R 429 R 1547214 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 8acn:A 26.2 76 458 116 477 Crystal structures of aconitase with isocitrate and nitroisocitrate bound 1e-22 106 binding nitroisocitric acid 451 R 434 R 1547214 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 8acn:A 26.2 76 458 116 477 Crystal structures of aconitase with isocitrate and nitroisocitrate bound 1e-22 106 binding iron/sulfur cluster 164 D 128 D 1547214 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 8acn:A 26.2 76 458 116 477 Crystal structures of aconitase with isocitrate and nitroisocitrate bound 1e-22 106 binding iron/sulfur cluster 166 H 130 H 1547214 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 8acn:A 26.2 76 458 116 477 Crystal structures of aconitase with isocitrate and nitroisocitrate bound 1e-22 106 binding iron/sulfur cluster 356 S 345 S 1547214 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 8acn:A 26.2 76 458 116 477 Crystal structures of aconitase with isocitrate and nitroisocitrate bound 1e-22 106 binding iron/sulfur cluster 357 C 346 C 1547214 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 8acn:A 26.2 76 458 116 477 Crystal structures of aconitase with isocitrate and nitroisocitrate bound 1e-22 106 binding iron/sulfur cluster 420 C 406 C 1547214 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 8acn:A 26.2 76 458 116 477 Crystal structures of aconitase with isocitrate and nitroisocitrate bound 1e-22 106 binding iron/sulfur cluster 423 C 409 C 1547214 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 8acn:A 26.2 76 458 116 477 Crystal structures of aconitase with isocitrate and nitroisocitrate bound 1e-22 106 binding iron/sulfur cluster 424 I 410 L 1547214 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 8acn:A 26.2 76 458 116 477 Crystal structures of aconitase with isocitrate and nitroisocitrate bound 1e-22 106 active site 99 1547214 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 8acn:A 26.2 76 458 116 477 Crystal structures of aconitase with isocitrate and nitroisocitrate bound 1e-22 106 active site 100 1547214 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 8acn:A 26.2 76 458 116 477 Crystal structures of aconitase with isocitrate and nitroisocitrate bound 1e-22 106 active site 641 1547214 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 8acn:A 26.2 76 458 116 477 Crystal structures of aconitase with isocitrate and nitroisocitrate bound 1e-22 106 active site 643 1547214 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 8acn:A 26.2 76 458 116 477 Crystal structures of aconitase with isocitrate and nitroisocitrate bound 1e-22 106 binding nitroisocitric acid 71 1547214 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 8acn:A 26.2 76 458 116 477 Crystal structures of aconitase with isocitrate and nitroisocitrate bound 1e-22 106 binding nitroisocitric acid 74 1547214 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 8acn:A 26.2 76 458 116 477 Crystal structures of aconitase with isocitrate and nitroisocitrate bound 1e-22 106 binding nitroisocitric acid 100 1547214 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 8acn:A 26.2 76 458 116 477 Crystal structures of aconitase with isocitrate and nitroisocitrate bound 1e-22 106 binding nitroisocitric acid 579 1547214 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 8acn:A 26.2 76 458 116 477 Crystal structures of aconitase with isocitrate and nitroisocitrate bound 1e-22 106 binding nitroisocitric acid 641 1547214 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 8acn:A 26.2 76 458 116 477 Crystal structures of aconitase with isocitrate and nitroisocitrate bound 1e-22 106 binding nitroisocitric acid 642 1547214 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 8acn:A 26.2 76 458 116 477 Crystal structures of aconitase with isocitrate and nitroisocitrate bound 1e-22 106 binding nitroisocitric acid 643 1547214 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 8acn:A 26.2 76 458 116 477 Crystal structures of aconitase with isocitrate and nitroisocitrate bound 1e-22 106 binding iron/sulfur cluster 100 1547214 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1fgh:A 26.2 76 458 116 477 Complex with 4-hydroxy-trans-aconitate 1e-22 106 active site 164 D 128 D 8942997 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1fgh:A 26.2 76 458 116 477 Complex with 4-hydroxy-trans-aconitate 1e-22 106 active site 446 R 429 R 8942997 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1fgh:A 26.2 76 458 116 477 Complex with 4-hydroxy-trans-aconitate 1e-22 106 binding 4-hydroxy-aconitate ion 164 D 128 D 8942997 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1fgh:A 26.2 76 458 116 477 Complex with 4-hydroxy-trans-aconitate 1e-22 106 binding 4-hydroxy-aconitate ion 165 S 129 S 8942997 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1fgh:A 26.2 76 458 116 477 Complex with 4-hydroxy-trans-aconitate 1e-22 106 binding 4-hydroxy-aconitate ion 446 R 429 R 8942997 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1fgh:A 26.2 76 458 116 477 Complex with 4-hydroxy-trans-aconitate 1e-22 106 binding 4-hydroxy-aconitate ion 451 R 434 R 8942997 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1fgh:A 26.2 76 458 116 477 Complex with 4-hydroxy-trans-aconitate 1e-22 106 binding iron/sulfur cluster 164 D 128 D 8942997 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1fgh:A 26.2 76 458 116 477 Complex with 4-hydroxy-trans-aconitate 1e-22 106 binding iron/sulfur cluster 166 H 130 H 8942997 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1fgh:A 26.2 76 458 116 477 Complex with 4-hydroxy-trans-aconitate 1e-22 106 binding iron/sulfur cluster 356 S 345 S 8942997 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1fgh:A 26.2 76 458 116 477 Complex with 4-hydroxy-trans-aconitate 1e-22 106 binding iron/sulfur cluster 357 C 346 C 8942997 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1fgh:A 26.2 76 458 116 477 Complex with 4-hydroxy-trans-aconitate 1e-22 106 binding iron/sulfur cluster 420 C 406 C 8942997 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1fgh:A 26.2 76 458 116 477 Complex with 4-hydroxy-trans-aconitate 1e-22 106 binding iron/sulfur cluster 423 C 409 C 8942997 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1fgh:A 26.2 76 458 116 477 Complex with 4-hydroxy-trans-aconitate 1e-22 106 binding iron/sulfur cluster 424 I 410 L 8942997 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1fgh:A 26.2 76 458 116 477 Complex with 4-hydroxy-trans-aconitate 1e-22 106 binding iron/sulfur cluster 451 R 434 R 8942997 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1fgh:A 26.2 76 458 116 477 Complex with 4-hydroxy-trans-aconitate 1e-22 106 active site 99 8942997 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1fgh:A 26.2 76 458 116 477 Complex with 4-hydroxy-trans-aconitate 1e-22 106 active site 100 8942997 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1fgh:A 26.2 76 458 116 477 Complex with 4-hydroxy-trans-aconitate 1e-22 106 active site 641 8942997 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1fgh:A 26.2 76 458 116 477 Complex with 4-hydroxy-trans-aconitate 1e-22 106 active site 643 8942997 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1fgh:A 26.2 76 458 116 477 Complex with 4-hydroxy-trans-aconitate 1e-22 106 binding 4-hydroxy-aconitate ion 71 8942997 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1fgh:A 26.2 76 458 116 477 Complex with 4-hydroxy-trans-aconitate 1e-22 106 binding 4-hydroxy-aconitate ion 74 8942997 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1fgh:A 26.2 76 458 116 477 Complex with 4-hydroxy-trans-aconitate 1e-22 106 binding 4-hydroxy-aconitate ion 100 8942997 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1fgh:A 26.2 76 458 116 477 Complex with 4-hydroxy-trans-aconitate 1e-22 106 binding 4-hydroxy-aconitate ion 579 8942997 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1fgh:A 26.2 76 458 116 477 Complex with 4-hydroxy-trans-aconitate 1e-22 106 binding 4-hydroxy-aconitate ion 641 8942997 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1fgh:A 26.2 76 458 116 477 Complex with 4-hydroxy-trans-aconitate 1e-22 106 binding 4-hydroxy-aconitate ion 642 8942997 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1fgh:A 26.2 76 458 116 477 Complex with 4-hydroxy-trans-aconitate 1e-22 106 binding 4-hydroxy-aconitate ion 643 8942997 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1fgh:A 26.2 76 458 116 477 Complex with 4-hydroxy-trans-aconitate 1e-22 106 binding iron/sulfur cluster 100 8942997 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1amj:A 26.2 76 458 116 477 Steric and conformational features of the aconitase mechanism 1e-22 106 active site 164 D 128 D 7675781 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1amj:A 26.2 76 458 116 477 Steric and conformational features of the aconitase mechanism 1e-22 106 active site 446 R 429 R 7675781 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1amj:A 26.2 76 458 116 477 Steric and conformational features of the aconitase mechanism 1e-22 106 binding iron/sulfur cluster 144 I 107 I 7675781 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1amj:A 26.2 76 458 116 477 Steric and conformational features of the aconitase mechanism 1e-22 106 binding iron/sulfur cluster 166 H 130 H 7675781 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1amj:A 26.2 76 458 116 477 Steric and conformational features of the aconitase mechanism 1e-22 106 binding iron/sulfur cluster 357 C 346 C 7675781 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1amj:A 26.2 76 458 116 477 Steric and conformational features of the aconitase mechanism 1e-22 106 binding iron/sulfur cluster 420 C 406 C 7675781 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1amj:A 26.2 76 458 116 477 Steric and conformational features of the aconitase mechanism 1e-22 106 binding iron/sulfur cluster 423 C 409 C 7675781 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1amj:A 26.2 76 458 116 477 Steric and conformational features of the aconitase mechanism 1e-22 106 active site 99 7675781 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1amj:A 26.2 76 458 116 477 Steric and conformational features of the aconitase mechanism 1e-22 106 active site 100 7675781 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1amj:A 26.2 76 458 116 477 Steric and conformational features of the aconitase mechanism 1e-22 106 active site 641 7675781 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1amj:A 26.2 76 458 116 477 Steric and conformational features of the aconitase mechanism 1e-22 106 active site 643 7675781 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1amj:A 26.2 76 458 116 477 Steric and conformational features of the aconitase mechanism 1e-22 106 binding sulfate ion 71 7675781 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1amj:A 26.2 76 458 116 477 Steric and conformational features of the aconitase mechanism 1e-22 106 binding sulfate ion 579 7675781 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1amj:A 26.2 76 458 116 477 Steric and conformational features of the aconitase mechanism 1e-22 106 binding sulfate ion 643 7675781 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1ami:A 26.2 76 458 116 477 Steric and conformational features of the aconitase mechanism 1e-22 106 active site 164 D 128 D 7675781 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1ami:A 26.2 76 458 116 477 Steric and conformational features of the aconitase mechanism 1e-22 106 active site 446 R 429 R 7675781 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1ami:A 26.2 76 458 116 477 Steric and conformational features of the aconitase mechanism 1e-22 106 binding alpha-methylisocitric acid 164 D 128 D 7675781 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1ami:A 26.2 76 458 116 477 Steric and conformational features of the aconitase mechanism 1e-22 106 binding alpha-methylisocitric acid 165 S 129 S 7675781 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1ami:A 26.2 76 458 116 477 Steric and conformational features of the aconitase mechanism 1e-22 106 binding alpha-methylisocitric acid 446 R 429 R 7675781 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1ami:A 26.2 76 458 116 477 Steric and conformational features of the aconitase mechanism 1e-22 106 binding alpha-methylisocitric acid 451 R 434 R 7675781 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1ami:A 26.2 76 458 116 477 Steric and conformational features of the aconitase mechanism 1e-22 106 binding iron/sulfur cluster 144 I 107 I 7675781 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1ami:A 26.2 76 458 116 477 Steric and conformational features of the aconitase mechanism 1e-22 106 binding iron/sulfur cluster 164 D 128 D 7675781 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1ami:A 26.2 76 458 116 477 Steric and conformational features of the aconitase mechanism 1e-22 106 binding iron/sulfur cluster 166 H 130 H 7675781 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1ami:A 26.2 76 458 116 477 Steric and conformational features of the aconitase mechanism 1e-22 106 binding iron/sulfur cluster 356 S 345 S 7675781 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1ami:A 26.2 76 458 116 477 Steric and conformational features of the aconitase mechanism 1e-22 106 binding iron/sulfur cluster 357 C 346 C 7675781 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1ami:A 26.2 76 458 116 477 Steric and conformational features of the aconitase mechanism 1e-22 106 binding iron/sulfur cluster 420 C 406 C 7675781 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1ami:A 26.2 76 458 116 477 Steric and conformational features of the aconitase mechanism 1e-22 106 binding iron/sulfur cluster 423 C 409 C 7675781 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1ami:A 26.2 76 458 116 477 Steric and conformational features of the aconitase mechanism 1e-22 106 binding iron/sulfur cluster 445 N 428 N 7675781 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1ami:A 26.2 76 458 116 477 Steric and conformational features of the aconitase mechanism 1e-22 106 active site 99 7675781 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1ami:A 26.2 76 458 116 477 Steric and conformational features of the aconitase mechanism 1e-22 106 active site 100 7675781 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1ami:A 26.2 76 458 116 477 Steric and conformational features of the aconitase mechanism 1e-22 106 active site 641 7675781 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1ami:A 26.2 76 458 116 477 Steric and conformational features of the aconitase mechanism 1e-22 106 active site 643 7675781 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1ami:A 26.2 76 458 116 477 Steric and conformational features of the aconitase mechanism 1e-22 106 binding alpha-methylisocitric acid 71 7675781 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1ami:A 26.2 76 458 116 477 Steric and conformational features of the aconitase mechanism 1e-22 106 binding alpha-methylisocitric acid 74 7675781 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1ami:A 26.2 76 458 116 477 Steric and conformational features of the aconitase mechanism 1e-22 106 binding alpha-methylisocitric acid 100 7675781 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1ami:A 26.2 76 458 116 477 Steric and conformational features of the aconitase mechanism 1e-22 106 binding alpha-methylisocitric acid 579 7675781 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1ami:A 26.2 76 458 116 477 Steric and conformational features of the aconitase mechanism 1e-22 106 binding alpha-methylisocitric acid 641 7675781 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1ami:A 26.2 76 458 116 477 Steric and conformational features of the aconitase mechanism 1e-22 106 binding alpha-methylisocitric acid 642 7675781 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1ami:A 26.2 76 458 116 477 Steric and conformational features of the aconitase mechanism 1e-22 106 binding alpha-methylisocitric acid 643 7675781 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1ami:A 26.2 76 458 116 477 Steric and conformational features of the aconitase mechanism 1e-22 106 binding iron/sulfur cluster 100 7675781 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1aco:A 26.2 76 458 116 477 Crystal structure of aconitase with transaconitate bound 1e-22 106 active site 164 D 128 D 8151704 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1aco:A 26.2 76 458 116 477 Crystal structure of aconitase with transaconitate bound 1e-22 106 active site 446 R 429 R 8151704 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1aco:A 26.2 76 458 116 477 Crystal structure of aconitase with transaconitate bound 1e-22 106 binding iron/sulfur cluster 144 I 107 I 8151704 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1aco:A 26.2 76 458 116 477 Crystal structure of aconitase with transaconitate bound 1e-22 106 binding iron/sulfur cluster 164 D 128 D 8151704 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1aco:A 26.2 76 458 116 477 Crystal structure of aconitase with transaconitate bound 1e-22 106 binding iron/sulfur cluster 166 H 130 H 8151704 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1aco:A 26.2 76 458 116 477 Crystal structure of aconitase with transaconitate bound 1e-22 106 binding iron/sulfur cluster 356 S 345 S 8151704 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1aco:A 26.2 76 458 116 477 Crystal structure of aconitase with transaconitate bound 1e-22 106 binding iron/sulfur cluster 357 C 346 C 8151704 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1aco:A 26.2 76 458 116 477 Crystal structure of aconitase with transaconitate bound 1e-22 106 binding iron/sulfur cluster 420 C 406 C 8151704 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1aco:A 26.2 76 458 116 477 Crystal structure of aconitase with transaconitate bound 1e-22 106 binding iron/sulfur cluster 423 C 409 C 8151704 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1aco:A 26.2 76 458 116 477 Crystal structure of aconitase with transaconitate bound 1e-22 106 binding iron/sulfur cluster 445 N 428 N 8151704 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1aco:A 26.2 76 458 116 477 Crystal structure of aconitase with transaconitate bound 1e-22 106 binding aconitate ion 164 D 128 D 8151704 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1aco:A 26.2 76 458 116 477 Crystal structure of aconitase with transaconitate bound 1e-22 106 binding aconitate ion 165 S 129 S 8151704 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1aco:A 26.2 76 458 116 477 Crystal structure of aconitase with transaconitate bound 1e-22 106 binding aconitate ion 446 R 429 R 8151704 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1aco:A 26.2 76 458 116 477 Crystal structure of aconitase with transaconitate bound 1e-22 106 binding aconitate ion 451 R 434 R 8151704 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1aco:A 26.2 76 458 116 477 Crystal structure of aconitase with transaconitate bound 1e-22 106 active site 99 8151704 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1aco:A 26.2 76 458 116 477 Crystal structure of aconitase with transaconitate bound 1e-22 106 active site 100 8151704 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1aco:A 26.2 76 458 116 477 Crystal structure of aconitase with transaconitate bound 1e-22 106 active site 641 8151704 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1aco:A 26.2 76 458 116 477 Crystal structure of aconitase with transaconitate bound 1e-22 106 active site 643 8151704 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1aco:A 26.2 76 458 116 477 Crystal structure of aconitase with transaconitate bound 1e-22 106 binding iron/sulfur cluster 100 8151704 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1aco:A 26.2 76 458 116 477 Crystal structure of aconitase with transaconitate bound 1e-22 106 binding aconitate ion 71 8151704 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1aco:A 26.2 76 458 116 477 Crystal structure of aconitase with transaconitate bound 1e-22 106 binding aconitate ion 579 8151704 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1aco:A 26.2 76 458 116 477 Crystal structure of aconitase with transaconitate bound 1e-22 106 binding aconitate ion 641 8151704 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1aco:A 26.2 76 458 116 477 Crystal structure of aconitase with transaconitate bound 1e-22 106 binding aconitate ion 642 8151704 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1aco:A 26.2 76 458 116 477 Crystal structure of aconitase with transaconitate bound 1e-22 106 binding aconitate ion 643 8151704 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1nis:A 26.2 76 458 116 477 Crystal structure of aconitase with trans-aconitate and nitrocitrate bound 1e-22 106 active site 164 D 128 D 8151704 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1nis:A 26.2 76 458 116 477 Crystal structure of aconitase with trans-aconitate and nitrocitrate bound 1e-22 106 active site 446 R 429 R 8151704 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1nis:A 26.2 76 458 116 477 Crystal structure of aconitase with trans-aconitate and nitrocitrate bound 1e-22 106 binding 2-hydroxy-2-nitromethyl succinic acid 164 D 128 D 8151704 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1nis:A 26.2 76 458 116 477 Crystal structure of aconitase with trans-aconitate and nitrocitrate bound 1e-22 106 binding 2-hydroxy-2-nitromethyl succinic acid 165 S 129 S 8151704 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1nis:A 26.2 76 458 116 477 Crystal structure of aconitase with trans-aconitate and nitrocitrate bound 1e-22 106 binding 2-hydroxy-2-nitromethyl succinic acid 446 R 429 R 8151704 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1nis:A 26.2 76 458 116 477 Crystal structure of aconitase with trans-aconitate and nitrocitrate bound 1e-22 106 binding 2-hydroxy-2-nitromethyl succinic acid 451 R 434 R 8151704 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1nis:A 26.2 76 458 116 477 Crystal structure of aconitase with trans-aconitate and nitrocitrate bound 1e-22 106 binding iron/sulfur cluster 144 I 107 I 8151704 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1nis:A 26.2 76 458 116 477 Crystal structure of aconitase with trans-aconitate and nitrocitrate bound 1e-22 106 binding iron/sulfur cluster 166 H 130 H 8151704 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1nis:A 26.2 76 458 116 477 Crystal structure of aconitase with trans-aconitate and nitrocitrate bound 1e-22 106 binding iron/sulfur cluster 356 S 345 S 8151704 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1nis:A 26.2 76 458 116 477 Crystal structure of aconitase with trans-aconitate and nitrocitrate bound 1e-22 106 binding iron/sulfur cluster 357 C 346 C 8151704 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1nis:A 26.2 76 458 116 477 Crystal structure of aconitase with trans-aconitate and nitrocitrate bound 1e-22 106 binding iron/sulfur cluster 420 C 406 C 8151704 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1nis:A 26.2 76 458 116 477 Crystal structure of aconitase with trans-aconitate and nitrocitrate bound 1e-22 106 binding iron/sulfur cluster 423 C 409 C 8151704 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1nis:A 26.2 76 458 116 477 Crystal structure of aconitase with trans-aconitate and nitrocitrate bound 1e-22 106 active site 99 8151704 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1nis:A 26.2 76 458 116 477 Crystal structure of aconitase with trans-aconitate and nitrocitrate bound 1e-22 106 active site 100 8151704 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1nis:A 26.2 76 458 116 477 Crystal structure of aconitase with trans-aconitate and nitrocitrate bound 1e-22 106 active site 641 8151704 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1nis:A 26.2 76 458 116 477 Crystal structure of aconitase with trans-aconitate and nitrocitrate bound 1e-22 106 active site 643 8151704 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1nis:A 26.2 76 458 116 477 Crystal structure of aconitase with trans-aconitate and nitrocitrate bound 1e-22 106 binding 2-hydroxy-2-nitromethyl succinic acid 71 8151704 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1nis:A 26.2 76 458 116 477 Crystal structure of aconitase with trans-aconitate and nitrocitrate bound 1e-22 106 binding 2-hydroxy-2-nitromethyl succinic acid 100 8151704 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1nis:A 26.2 76 458 116 477 Crystal structure of aconitase with trans-aconitate and nitrocitrate bound 1e-22 106 binding 2-hydroxy-2-nitromethyl succinic acid 579 8151704 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1nis:A 26.2 76 458 116 477 Crystal structure of aconitase with trans-aconitate and nitrocitrate bound 1e-22 106 binding 2-hydroxy-2-nitromethyl succinic acid 641 8151704 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1nis:A 26.2 76 458 116 477 Crystal structure of aconitase with trans-aconitate and nitrocitrate bound 1e-22 106 binding 2-hydroxy-2-nitromethyl succinic acid 642 8151704 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 1nis:A 26.2 76 458 116 477 Crystal structure of aconitase with trans-aconitate and nitrocitrate bound 1e-22 106 binding iron/sulfur cluster 100 8151704 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit SwissProt ACO3M_ARATH 26.7 103 459 268 663 Aconitate hydratase 3, mitochondrial; Aconitase 3; mACO1; Citrate hydro-lyase 3; EC 4.2.1.3 from Arabidopsis thaliana (Mouse-ear cress) 2e-21 102 modified: Phosphoserine 91 25307043 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit SwissProt ACNA_BACSU 25.9 107 459 198 580 Aconitate hydratase A; ACN; Aconitase; Aconitate/2-methylaconitate hydratase; Iron-responsive protein-like; IRP-like; RNA-binding protein; EC 4.2.1.3; EC 4.2.1.- from Bacillus subtilis (strain 168) 1e-18 93.2 mutation to S: Loss of aconitase activity. It is... 450 C 346 C 23354745 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit SwissProt ACNA_BACSU 25.9 107 459 198 580 Aconitate hydratase A; ACN; Aconitase; Aconitate/2-methylaconitate hydratase; Iron-responsive protein-like; IRP-like; RNA-binding protein; EC 4.2.1.3; EC 4.2.1.- from Bacillus subtilis (strain 168) 1e-18 93.2 modified: Initiator methionine, Removed 1 3110133 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit SwissProt ACNA_BACSU 25.9 107 459 198 580 Aconitate hydratase A; ACN; Aconitase; Aconitate/2-methylaconitate hydratase; Iron-responsive protein-like; IRP-like; RNA-binding protein; EC 4.2.1.3; EC 4.2.1.- from Bacillus subtilis (strain 168) 1e-18 93.2 R→E: Same aconitase activity compared to the wild-type. It... 741 23354745 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 2b3x:A 24.4 103 458 171 565 Structure of an orthorhombic crystal form of human cytosolic aconitase (irp1) 1e-16 86.3 active site 204 D 128 D 16407072 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 2b3x:A 24.4 103 458 171 565 Structure of an orthorhombic crystal form of human cytosolic aconitase (irp1) 1e-16 86.3 active site 535 R 429 R 16407072 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 2b3x:A 24.4 103 458 171 565 Structure of an orthorhombic crystal form of human cytosolic aconitase (irp1) 1e-16 86.3 binding iron/sulfur cluster 175 I 107 I 16407072 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 2b3x:A 24.4 103 458 171 565 Structure of an orthorhombic crystal form of human cytosolic aconitase (irp1) 1e-16 86.3 binding iron/sulfur cluster 206 H 130 H 16407072 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 2b3x:A 24.4 103 458 171 565 Structure of an orthorhombic crystal form of human cytosolic aconitase (irp1) 1e-16 86.3 binding iron/sulfur cluster 436 C 346 C 16407072 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 2b3x:A 24.4 103 458 171 565 Structure of an orthorhombic crystal form of human cytosolic aconitase (irp1) 1e-16 86.3 binding iron/sulfur cluster 502 C 406 C 16407072 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 2b3x:A 24.4 103 458 171 565 Structure of an orthorhombic crystal form of human cytosolic aconitase (irp1) 1e-16 86.3 binding iron/sulfur cluster 505 C 409 C 16407072 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 2b3x:A 24.4 103 458 171 565 Structure of an orthorhombic crystal form of human cytosolic aconitase (irp1) 1e-16 86.3 binding iron/sulfur cluster 506 I 410 L 16407072 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 2b3x:A 24.4 103 458 171 565 Structure of an orthorhombic crystal form of human cytosolic aconitase (irp1) 1e-16 86.3 binding iron/sulfur cluster 534 N 428 N 16407072 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 2b3x:A 24.4 103 458 171 565 Structure of an orthorhombic crystal form of human cytosolic aconitase (irp1) 1e-16 86.3 active site 124 16407072 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 2b3x:A 24.4 103 458 171 565 Structure of an orthorhombic crystal form of human cytosolic aconitase (irp1) 1e-16 86.3 active site 125 16407072 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 2b3x:A 24.4 103 458 171 565 Structure of an orthorhombic crystal form of human cytosolic aconitase (irp1) 1e-16 86.3 active site 777 16407072 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit PDB 2b3x:A 24.4 103 458 171 565 Structure of an orthorhombic crystal form of human cytosolic aconitase (irp1) 1e-16 86.3 active site 779 16407072 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit SwissProt ACOHC_HUMAN 24.4 103 458 172 566 Cytoplasmic aconitate hydratase; Aconitase; Citrate hydro-lyase; Ferritin repressor protein; Iron regulatory protein 1; IRP1; Iron-responsive element-binding protein 1; IRE-BP 1; EC 4.2.1.3 from Homo sapiens (Human) 1e-16 86.3 mutation to S: No effect on aconitase activity or... 300 C 223 S 8041788 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit SwissProt ACOHC_HUMAN 24.4 103 458 172 566 Cytoplasmic aconitate hydratase; Aconitase; Citrate hydro-lyase; Ferritin repressor protein; Iron regulatory protein 1; IRP1; Iron-responsive element-binding protein 1; IRE-BP 1; EC 4.2.1.3 from Homo sapiens (Human) 1e-16 86.3 to M: in dbSNP:rs150373174 318 T 241 D 23033978 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit SwissProt ACOHC_HUMAN 24.4 103 458 172 566 Cytoplasmic aconitate hydratase; Aconitase; Citrate hydro-lyase; Ferritin repressor protein; Iron regulatory protein 1; IRP1; Iron-responsive element-binding protein 1; IRE-BP 1; EC 4.2.1.3 from Homo sapiens (Human) 1e-16 86.3 mutation to S: Loss of aconitase activity. Leads to... 437 C 346 C 8041788 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit SwissProt ACOHC_HUMAN 24.4 103 458 172 566 Cytoplasmic aconitate hydratase; Aconitase; Citrate hydro-lyase; Ferritin repressor protein; Iron regulatory protein 1; IRP1; Iron-responsive element-binding protein 1; IRE-BP 1; EC 4.2.1.3 from Homo sapiens (Human) 1e-16 86.3 mutation to S: Loss of aconitase activity. Leads to... 503 C 406 C 8041788 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit SwissProt ACOHC_HUMAN 24.4 103 458 172 566 Cytoplasmic aconitate hydratase; Aconitase; Citrate hydro-lyase; Ferritin repressor protein; Iron regulatory protein 1; IRP1; Iron-responsive element-binding protein 1; IRE-BP 1; EC 4.2.1.3 from Homo sapiens (Human) 1e-16 86.3 mutation to S: Loss of aconitase activity. Leads to... 506 C 409 C 8041788 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit SwissProt ACOHC_HUMAN 24.4 103 458 172 566 Cytoplasmic aconitate hydratase; Aconitase; Citrate hydro-lyase; Ferritin repressor protein; Iron regulatory protein 1; IRP1; Iron-responsive element-binding protein 1; IRE-BP 1; EC 4.2.1.3 from Homo sapiens (Human) 1e-16 86.3 mutation to Q: Strongly reduced RNA binding. 536 R 429 R 8041788 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit SwissProt ACOHC_HUMAN 24.4 103 458 172 566 Cytoplasmic aconitate hydratase; Aconitase; Citrate hydro-lyase; Ferritin repressor protein; Iron regulatory protein 1; IRP1; Iron-responsive element-binding protein 1; IRE-BP 1; EC 4.2.1.3 from Homo sapiens (Human) 1e-16 86.3 mutation to Q: Strongly reduced RNA binding. 541 R 434 R 8041788 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit SwissProt ACOHC_HUMAN 24.4 103 458 172 566 Cytoplasmic aconitate hydratase; Aconitase; Citrate hydro-lyase; Ferritin repressor protein; Iron regulatory protein 1; IRP1; Iron-responsive element-binding protein 1; IRE-BP 1; EC 4.2.1.3 from Homo sapiens (Human) 1e-16 86.3 R→K: No effect on RNA binding. 699 8041788 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit SwissProt ACOHC_HUMAN 24.4 103 458 172 566 Cytoplasmic aconitate hydratase; Aconitase; Citrate hydro-lyase; Ferritin repressor protein; Iron regulatory protein 1; IRP1; Iron-responsive element-binding protein 1; IRE-BP 1; EC 4.2.1.3 from Homo sapiens (Human) 1e-16 86.3 S→A: No effect on iron-regulated RNA binding. Loss of... 778 8041788 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit SwissProt ACOHC_HUMAN 24.4 103 458 172 566 Cytoplasmic aconitate hydratase; Aconitase; Citrate hydro-lyase; Ferritin repressor protein; Iron regulatory protein 1; IRP1; Iron-responsive element-binding protein 1; IRE-BP 1; EC 4.2.1.3 from Homo sapiens (Human) 1e-16 86.3 R→Q: Nearly abolishes RNA binding. 780 8041788 CA265_RS15830 CA265_RS15830 3-isopropylmalate dehydratase large subunit SwissProt ACNA_MYCS2 24.1 103 458 178 607 Aconitate hydratase A; ACN; Aconitase; (2R,3S)-2-methylisocitrate dehydratase; (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate dehydratase; Iron-responsive protein-like; IRP-like; Probable 2-methyl-cis-aconitate hydratase; RNA-binding protein; EC 4.2.1.3; EC 4.2.1.99 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) 7e-15 80.5 modified: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in... 394 K - 20094657