queryId subjectDb subjectId identity queryAlnBegin queryAlnEnd sujectAlnBegin subjectAlnEnd subjectDescription evalue bits subjectSite subjectSiteRange subjectSiteSeq querySiteRange querySiteSeq pubMedIds CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 1wa3:D 33.3 17 222 11 201 Mechanism of the class i kdpg aldolase 5e-22 102 active site 39 E 45 E 16403639 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 1wa3:D 33.3 17 222 11 201 Mechanism of the class i kdpg aldolase 5e-22 102 active site 43 T 49 R 16403639 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 1wa3:D 33.3 17 222 11 201 Mechanism of the class i kdpg aldolase 5e-22 102 active site 128 K 137 K 16403639 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 1wa3:D 33.3 17 222 11 201 Mechanism of the class i kdpg aldolase 5e-22 102 binding pyruvic acid 68 T 77 S 16403639 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 1wa3:D 33.3 17 222 11 201 Mechanism of the class i kdpg aldolase 5e-22 102 binding pyruvic acid 88 S 97 G 16403639 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 1wa3:D 33.3 17 222 11 201 Mechanism of the class i kdpg aldolase 5e-22 102 binding pyruvic acid 89 P 98 P 16403639 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 1wa3:D 33.3 17 222 11 201 Mechanism of the class i kdpg aldolase 5e-22 102 binding pyruvic acid 128 K 137 K 16403639 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 1wa3:D 33.3 17 222 11 201 Mechanism of the class i kdpg aldolase 5e-22 102 binding pyruvic acid 130 F 139 F 16403639 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 1wa3:D 33.3 17 222 11 201 Mechanism of the class i kdpg aldolase 5e-22 102 binding sulfate ion 157 G 167 G 16403639 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 1wa3:D 33.3 17 222 11 201 Mechanism of the class i kdpg aldolase 5e-22 102 binding sulfate ion 177 G 189 G 16403639 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 1wa3:D 33.3 17 222 11 201 Mechanism of the class i kdpg aldolase 5e-22 102 binding sulfate ion 178 S 190 S 16403639 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 1eua:A 29.7 34 215 34 209 Schiff base intermediate in kdpg aldolase from escherichia coli 3e-15 80.1 active site 45 E 45 E 11274385 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 1eua:A 29.7 34 215 34 209 Schiff base intermediate in kdpg aldolase from escherichia coli 3e-15 80.1 active site 49 R 49 R 11274385 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 1eua:A 29.7 34 215 34 209 Schiff base intermediate in kdpg aldolase from escherichia coli 3e-15 80.1 active site 133 K 137 K 11274385 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 1eua:A 29.7 34 215 34 209 Schiff base intermediate in kdpg aldolase from escherichia coli 3e-15 80.1 binding pyruvic acid 45 E 45 E 11274385 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 1eua:A 29.7 34 215 34 209 Schiff base intermediate in kdpg aldolase from escherichia coli 3e-15 80.1 binding pyruvic acid 73 T 77 S 11274385 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 1eua:A 29.7 34 215 34 209 Schiff base intermediate in kdpg aldolase from escherichia coli 3e-15 80.1 binding pyruvic acid 92 I 96 V 11274385 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 1eua:A 29.7 34 215 34 209 Schiff base intermediate in kdpg aldolase from escherichia coli 3e-15 80.1 binding pyruvic acid 133 K 137 K 11274385 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase SwissProt ALKH_ECOLI 29.7 34 215 34 209 KHG/KDPG aldolase; EC 4.1.3.16; EC 4.1.2.14 from Escherichia coli (strain K12) 3e-15 80.1 mutation to N: 50-fold decrease in catalytic efficiency and... 45 E 45 E 16403639,17981470 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase SwissProt ALKH_ECOLI 29.7 34 215 34 209 KHG/KDPG aldolase; EC 4.1.3.16; EC 4.1.2.14 from Escherichia coli (strain K12) 3e-15 80.1 binding 49 R 49 R 16403639 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase SwissProt ALKH_ECOLI 29.7 34 215 34 209 KHG/KDPG aldolase; EC 4.1.3.16; EC 4.1.2.14 from Escherichia coli (strain K12) 3e-15 80.1 binding 73 T 77 S 16403639 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase SwissProt ALKH_ECOLI 29.7 34 215 34 209 KHG/KDPG aldolase; EC 4.1.3.16; EC 4.1.2.14 from Escherichia coli (strain K12) 3e-15 80.1 binding covalent; mutation to Q: Absence of aldolase activity. Shows a... 133 K 137 K 11342129,16403639 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase SwissProt ALKH_ECOLI 29.7 34 215 34 209 KHG/KDPG aldolase; EC 4.1.3.16; EC 4.1.2.14 from Escherichia coli (strain K12) 3e-15 80.1 binding ; mutation to K: Shows activity significantly greater than wild-type....; mutation to V: Little stereoselectivity, accepting KDPG and KDPGal... 161 T 165 T 11342129,16403639,17981470 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase SwissProt ALKH_ECOLI 29.7 34 215 34 209 KHG/KDPG aldolase; EC 4.1.3.16; EC 4.1.2.14 from Escherichia coli (strain K12) 3e-15 80.1 binding 163 G 167 G 16403639 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase SwissProt ALKH_ECOLI 29.7 34 215 34 209 KHG/KDPG aldolase; EC 4.1.3.16; EC 4.1.2.14 from Escherichia coli (strain K12) 3e-15 80.1 mutation to S: Shows activity significantly greater than wild-type. 168 N 174 S 11342129 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase SwissProt ALKH_ECOLI 29.7 34 215 34 209 KHG/KDPG aldolase; EC 4.1.3.16; EC 4.1.2.14 from Escherichia coli (strain K12) 3e-15 80.1 binding 184 S 190 S 16403639 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 1wau:A 29.1 34 215 34 209 Structure of kdpg aldolase e45n mutant 1e-14 78.2 active site 45 N 45 E 16403639 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 1wau:A 29.1 34 215 34 209 Structure of kdpg aldolase e45n mutant 1e-14 78.2 active site 49 R 49 R 16403639 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 1wau:A 29.1 34 215 34 209 Structure of kdpg aldolase e45n mutant 1e-14 78.2 active site 133 K 137 K 16403639 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 1wau:A 29.1 34 215 34 209 Structure of kdpg aldolase e45n mutant 1e-14 78.2 binding sulfate ion 162 G 166 G 16403639 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 1wau:A 29.1 34 215 34 209 Structure of kdpg aldolase e45n mutant 1e-14 78.2 binding sulfate ion 163 G 167 G 16403639 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 1wau:A 29.1 34 215 34 209 Structure of kdpg aldolase e45n mutant 1e-14 78.2 binding sulfate ion 184 S 190 S 16403639 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 2c0a:B 29.1 34 215 35 210 Mechanism of the class i kdpg aldolase 1e-14 78.2 active site 46 N 45 E 16403639 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 2c0a:B 29.1 34 215 35 210 Mechanism of the class i kdpg aldolase 1e-14 78.2 active site 50 R 49 R 16403639 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 2c0a:B 29.1 34 215 35 210 Mechanism of the class i kdpg aldolase 1e-14 78.2 active site 134 K 137 K 16403639 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 2c0a:B 29.1 34 215 35 210 Mechanism of the class i kdpg aldolase 1e-14 78.2 binding phosphate ion 132 E 135 I 16403639 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 2c0a:B 29.1 34 215 35 210 Mechanism of the class i kdpg aldolase 1e-14 78.2 binding phosphate ion 1 16403639 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 2c0a:B 29.1 34 215 35 210 Mechanism of the class i kdpg aldolase 1e-14 78.2 binding phosphate ion 5 16403639 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 2c0a:B 29.1 34 215 35 210 Mechanism of the class i kdpg aldolase 1e-14 78.2 binding phosphate ion 8 16403639 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 2c0a:B 29.1 34 215 35 210 Mechanism of the class i kdpg aldolase 1e-14 78.2 binding phosphate ion 9 16403639 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 2c0a:B 29.1 34 215 35 210 Mechanism of the class i kdpg aldolase 1e-14 78.2 binding phosphate ion 10 16403639 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 3vcr:A 28.2 17 216 14 213 Crystal structure of a putative kdpg (2-keto-3-deoxy-6- phosphogluconate) aldolase from oleispira antarctica 2e-14 77.8 active site 42 E 45 E 23877221 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 3vcr:A 28.2 17 216 14 213 Crystal structure of a putative kdpg (2-keto-3-deoxy-6- phosphogluconate) aldolase from oleispira antarctica 2e-14 77.8 active site 46 R 49 R 23877221 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 3vcr:A 28.2 17 216 14 213 Crystal structure of a putative kdpg (2-keto-3-deoxy-6- phosphogluconate) aldolase from oleispira antarctica 2e-14 77.8 active site 136 K 137 K 23877221 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 3vcr:A 28.2 17 216 14 213 Crystal structure of a putative kdpg (2-keto-3-deoxy-6- phosphogluconate) aldolase from oleispira antarctica 2e-14 77.8 binding pyruvic acid 46 R 49 R 23877221 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 3vcr:A 28.2 17 216 14 213 Crystal structure of a putative kdpg (2-keto-3-deoxy-6- phosphogluconate) aldolase from oleispira antarctica 2e-14 77.8 binding pyruvic acid 70 T 77 S 23877221 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 3vcr:A 28.2 17 216 14 213 Crystal structure of a putative kdpg (2-keto-3-deoxy-6- phosphogluconate) aldolase from oleispira antarctica 2e-14 77.8 binding pyruvic acid 89 V 96 V 23877221 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 3vcr:A 28.2 17 216 14 213 Crystal structure of a putative kdpg (2-keto-3-deoxy-6- phosphogluconate) aldolase from oleispira antarctica 2e-14 77.8 binding pyruvic acid 90 S 97 G 23877221 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 3vcr:A 28.2 17 216 14 213 Crystal structure of a putative kdpg (2-keto-3-deoxy-6- phosphogluconate) aldolase from oleispira antarctica 2e-14 77.8 binding pyruvic acid 91 P 98 P 23877221 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 1mxs:A 27.6 2 217 3 213 Crystal structure of 2-keto-3-deoxy-6-phosphogluconate (kdpg) aldolase from pseudomonas putida. 2e-12 71.2 active site 47 E 45 E 12876349 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 1mxs:A 27.6 2 217 3 213 Crystal structure of 2-keto-3-deoxy-6-phosphogluconate (kdpg) aldolase from pseudomonas putida. 2e-12 71.2 active site 51 R 49 R 12876349 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 1mxs:A 27.6 2 217 3 213 Crystal structure of 2-keto-3-deoxy-6-phosphogluconate (kdpg) aldolase from pseudomonas putida. 2e-12 71.2 active site 135 K 137 K 12876349 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 1mxs:A 27.6 2 217 3 213 Crystal structure of 2-keto-3-deoxy-6-phosphogluconate (kdpg) aldolase from pseudomonas putida. 2e-12 71.2 binding sulfate ion 47 E 45 E 12876349 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 1mxs:A 27.6 2 217 3 213 Crystal structure of 2-keto-3-deoxy-6-phosphogluconate (kdpg) aldolase from pseudomonas putida. 2e-12 71.2 binding sulfate ion 51 R 49 R 12876349 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 1mxs:A 27.6 2 217 3 213 Crystal structure of 2-keto-3-deoxy-6-phosphogluconate (kdpg) aldolase from pseudomonas putida. 2e-12 71.2 binding sulfate ion 75 T 77 S 12876349 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 1mxs:A 27.6 2 217 3 213 Crystal structure of 2-keto-3-deoxy-6-phosphogluconate (kdpg) aldolase from pseudomonas putida. 2e-12 71.2 binding sulfate ion 94 V 96 V 12876349 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 1mxs:A 27.6 2 217 3 213 Crystal structure of 2-keto-3-deoxy-6-phosphogluconate (kdpg) aldolase from pseudomonas putida. 2e-12 71.2 binding sulfate ion 95 T 97 G 12876349 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 1mxs:A 27.6 2 217 3 213 Crystal structure of 2-keto-3-deoxy-6-phosphogluconate (kdpg) aldolase from pseudomonas putida. 2e-12 71.2 binding sulfate ion 96 P 98 P 12876349 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 1mxs:A 27.6 2 217 3 213 Crystal structure of 2-keto-3-deoxy-6-phosphogluconate (kdpg) aldolase from pseudomonas putida. 2e-12 71.2 binding sulfate ion 135 K 137 K 12876349 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase SwissProt ALKD_PSEPU 28.0 2 217 13 223 2-dehydro-3-deoxy-phosphogluconate aldolase; KDPG-aldolase; Phospho-2-dehydro-3-deoxygluconate aldolase; Phospho-2-keto-3-deoxygluconate aldolase; EC 4.1.2.14 from Pseudomonas putida (Arthrobacter siderocapsulatus) 3e-12 70.5 active site, Schiff-base intermediate with substrate 145 K 137 K 6988426 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase SwissProt ALKD_PSEPU 28.0 2 217 13 223 2-dehydro-3-deoxy-phosphogluconate aldolase; KDPG-aldolase; Phospho-2-dehydro-3-deoxygluconate aldolase; Phospho-2-keto-3-deoxygluconate aldolase; EC 4.1.2.14 from Pseudomonas putida (Arthrobacter siderocapsulatus) 3e-12 70.5 modified: Initiator methionine, Removed 1 6988426 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 5xsf:A 28.7 17 173 14 165 Crystal structure of the 2-keto-3-deoxy-6-phosphogluconate aldolase of zymomonas mobilis zm4 with 3-phosphoglycerate 2e-10 64.3 binding 3-hydroxypyruvic acid 19 V 22 Y CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 5xsf:A 28.7 17 173 14 165 Crystal structure of the 2-keto-3-deoxy-6-phosphogluconate aldolase of zymomonas mobilis zm4 with 3-phosphoglycerate 2e-10 64.3 binding 3-hydroxypyruvic acid 21 E 24 P CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 5xsf:A 28.7 17 173 14 165 Crystal structure of the 2-keto-3-deoxy-6-phosphogluconate aldolase of zymomonas mobilis zm4 with 3-phosphoglycerate 2e-10 64.3 binding 3-hydroxypyruvic acid 22 D 25 D CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 5xsf:A 28.7 17 173 14 165 Crystal structure of the 2-keto-3-deoxy-6-phosphogluconate aldolase of zymomonas mobilis zm4 with 3-phosphoglycerate 2e-10 64.3 binding 3-hydroxypyruvic acid 25 D 28 V CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 6ovi:A 25.0 17 208 14 199 Crystal structure of kdpg aldolase from legionella pneumophila with pyruvate captured at low ph as a covalent carbinolamine intermediate 3e-10 63.9 binding 2,2-bis(oxidanyl)propanoic acid 42 E 45 E CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 6ovi:A 25.0 17 208 14 199 Crystal structure of kdpg aldolase from legionella pneumophila with pyruvate captured at low ph as a covalent carbinolamine intermediate 3e-10 63.9 binding 2,2-bis(oxidanyl)propanoic acid 46 R 49 R CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 6ovi:A 25.0 17 208 14 199 Crystal structure of kdpg aldolase from legionella pneumophila with pyruvate captured at low ph as a covalent carbinolamine intermediate 3e-10 63.9 binding 2,2-bis(oxidanyl)propanoic acid 70 T 77 S CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 6ovi:A 25.0 17 208 14 199 Crystal structure of kdpg aldolase from legionella pneumophila with pyruvate captured at low ph as a covalent carbinolamine intermediate 3e-10 63.9 binding 2,2-bis(oxidanyl)propanoic acid 91 P 98 P CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 6ovi:A 25.0 17 208 14 199 Crystal structure of kdpg aldolase from legionella pneumophila with pyruvate captured at low ph as a covalent carbinolamine intermediate 3e-10 63.9 binding 2,2-bis(oxidanyl)propanoic acid 130 K 137 K CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 6ovi:A 25.0 17 208 14 199 Crystal structure of kdpg aldolase from legionella pneumophila with pyruvate captured at low ph as a covalent carbinolamine intermediate 3e-10 63.9 binding 2,2-bis(oxidanyl)propanoic acid 132 F 139 F CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 2v82:A 28.5 70 216 58 205 Kdpgal complexed to kdpgal 7e-10 62.4 active site 125 K 137 K 17981470 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 2v82:A 28.5 70 216 58 205 Kdpgal complexed to kdpgal 7e-10 62.4 binding 2-keto-deoxy-galactose 65 T 77 S 17981470 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 2v82:A 28.5 70 216 58 205 Kdpgal complexed to kdpgal 7e-10 62.4 binding 2-keto-deoxy-galactose 84 V 96 V 17981470 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 2v82:A 28.5 70 216 58 205 Kdpgal complexed to kdpgal 7e-10 62.4 binding 2-keto-deoxy-galactose 85 T 97 G 17981470 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 2v82:A 28.5 70 216 58 205 Kdpgal complexed to kdpgal 7e-10 62.4 binding 2-keto-deoxy-galactose 125 K 137 K 17981470 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 2v82:A 28.5 70 216 58 205 Kdpgal complexed to kdpgal 7e-10 62.4 binding 2-keto-deoxy-galactose 127 F 139 F 17981470 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 2v82:A 28.5 70 216 58 205 Kdpgal complexed to kdpgal 7e-10 62.4 binding 2-keto-deoxy-galactose 153 V 165 T 17981470 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 2v82:A 28.5 70 216 58 205 Kdpgal complexed to kdpgal 7e-10 62.4 binding 2-keto-deoxy-galactose 175 G 189 G 17981470 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 2v82:A 28.5 70 216 58 205 Kdpgal complexed to kdpgal 7e-10 62.4 binding 2-keto-deoxy-galactose 176 S 190 S 17981470 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 2v82:A 28.5 70 216 58 205 Kdpgal complexed to kdpgal 7e-10 62.4 binding 2-keto-deoxy-galactose 205 L 216 L 17981470 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 2v82:A 28.5 70 216 58 205 Kdpgal complexed to kdpgal 7e-10 62.4 active site 36 17981470 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 2v82:A 28.5 70 216 58 205 Kdpgal complexed to kdpgal 7e-10 62.4 active site 40 17981470 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase PDB 2v82:A 28.5 70 216 58 205 Kdpgal complexed to kdpgal 7e-10 62.4 binding 2-keto-deoxy-galactose 13 17981470 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase SwissProt DGOA_ECOLI 28.0 70 215 59 205 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; 2-oxo-3-deoxygalactonate 6-phosphate aldolase; 6-phospho-2-dehydro-3-deoxygalactonate aldolase; 6-phospho-2-keto-3-deoxygalactonate aldolase; KDPGal; EC 4.1.2.21 from Escherichia coli (strain K12) 2e-09 60.8 binding 66 T 77 S 17981470 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase SwissProt DGOA_ECOLI 28.0 70 215 59 205 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; 2-oxo-3-deoxygalactonate 6-phosphate aldolase; 6-phospho-2-dehydro-3-deoxygalactonate aldolase; 6-phospho-2-keto-3-deoxygalactonate aldolase; KDPGal; EC 4.1.2.21 from Escherichia coli (strain K12) 2e-09 60.8 active site, Schiff-base intermediate with substrate; binding covalent 126 K 137 K 17981470 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase SwissProt DGOA_ECOLI 28.0 70 215 59 205 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; 2-oxo-3-deoxygalactonate 6-phosphate aldolase; 6-phospho-2-dehydro-3-deoxygalactonate aldolase; 6-phospho-2-keto-3-deoxygalactonate aldolase; KDPGal; EC 4.1.2.21 from Escherichia coli (strain K12) 2e-09 60.8 mutation to T: Little stereoselectivity, accepting KDPG and KDPGal... 154 V 165 T 17981470 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase SwissProt DGOA_ECOLI 28.0 70 215 59 205 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; 2-oxo-3-deoxygalactonate 6-phosphate aldolase; 6-phospho-2-dehydro-3-deoxygalactonate aldolase; 6-phospho-2-keto-3-deoxygalactonate aldolase; KDPGal; EC 4.1.2.21 from Escherichia coli (strain K12) 2e-09 60.8 binding 14 17981470 CCNA_01562 CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase SwissProt DGOA_ECOLI 28.0 70 215 59 205 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; 2-oxo-3-deoxygalactonate 6-phosphate aldolase; 6-phospho-2-dehydro-3-deoxygalactonate aldolase; 6-phospho-2-keto-3-deoxygalactonate aldolase; KDPGal; EC 4.1.2.21 from Escherichia coli (strain K12) 2e-09 60.8 E→N: 50-fold decrease in catalytic efficiency and 6-fold decrease... 37 17981470