queryId subjectDb subjectId identity queryAlnBegin queryAlnEnd sujectAlnBegin subjectAlnEnd subjectDescription evalue bits subjectSite subjectSiteRange subjectSiteSeq querySiteRange querySiteSeq pubMedIds PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt LYSP_ECOLI 40.7 6 457 3 469 Lysine-specific permease LysP; Lysine transporter LysP; Trigger transporter LysP from Escherichia coli (strain K12) 1e-97 355 mutation to L: Retains 4% of wild-type lysine uptake... 102 Y 105 Y 24056175 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt LYSP_ECOLI 40.7 6 457 3 469 Lysine-specific permease LysP; Lysine transporter LysP; Trigger transporter LysP from Escherichia coli (strain K12) 1e-97 355 mutation to L: Retains 20% of wild-type lysine uptake... 106 W 109 W 24056175 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt LYSP_ECOLI 40.7 6 457 3 469 Lysine-specific permease LysP; Lysine transporter LysP; Trigger transporter LysP from Escherichia coli (strain K12) 1e-97 355 mutation to A: Retains 24% of wild-type lysine uptake... 163 K 166 K 24056175 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt LYSP_ECOLI 40.7 6 457 3 469 Lysine-specific permease LysP; Lysine transporter LysP; Trigger transporter LysP from Escherichia coli (strain K12) 1e-97 355 mutation to L: Retains 13% of wild-type lysine uptake... 216 F 220 F 24056175 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt LYSP_ECOLI 40.7 6 457 3 469 Lysine-specific permease LysP; Lysine transporter LysP; Trigger transporter LysP from Escherichia coli (strain K12) 1e-97 355 mutation to A: Abolishes lysine uptake. Strongly inhibits CadC. 222 E 226 E 24056175 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt LYSP_ECOLI 40.7 6 457 3 469 Lysine-specific permease LysP; Lysine transporter LysP; Trigger transporter LysP from Escherichia coli (strain K12) 1e-97 355 mutation to V: Abolishes lysine uptake. Shows significant less... 230 E 234 E 24056175 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt LYSP_ECOLI 40.7 6 457 3 469 Lysine-specific permease LysP; Lysine transporter LysP; Trigger transporter LysP from Escherichia coli (strain K12) 1e-97 355 Essential for the stimulus-dependent interaction with CadC; mutation to A: Retains 88% of wild-type lysine uptake... 275 D - 24056175 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt LYSP_ECOLI 40.7 6 457 3 469 Lysine-specific permease LysP; Lysine transporter LysP; Trigger transporter LysP from Escherichia coli (strain K12) 1e-97 355 Essential for the stimulus-dependent interaction with CadC; mutation to A: Retains 88% of wild-type lysine uptake... 278 D - 24056175 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt LYSP_ECOLI 40.7 6 457 3 469 Lysine-specific permease LysP; Lysine transporter LysP; Trigger transporter LysP from Escherichia coli (strain K12) 1e-97 355 mutation to A: Retains 14% of wild-type lysine uptake... 438 E 434 D 24056175 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt LYSP_ECOLI 40.7 6 457 3 469 Lysine-specific permease LysP; Lysine transporter LysP; Trigger transporter LysP from Escherichia coli (strain K12) 1e-97 355 mutation to A: Retains 11% of wild-type lysine uptake... 443 D - 24056175 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt LYSP_ECOLI 40.7 6 457 3 469 Lysine-specific permease LysP; Lysine transporter LysP; Trigger transporter LysP from Escherichia coli (strain K12) 1e-97 355 mutation to A: Retains 13% of wild-type lysine uptake... 446 D - 24056175 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt LYSP_ECOLI 40.7 6 457 3 469 Lysine-specific permease LysP; Lysine transporter LysP; Trigger transporter LysP from Escherichia coli (strain K12) 1e-97 355 modified: Initiator methionine, Removed 1 7551055 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt GABP_BACSU 39.3 10 441 2 429 Gamma-aminobutyric acid permease; GABA permease; 4-aminobutyrate permease; Gamma-aminobutyrate permease; Proline transporter GabP from Bacillus subtilis (strain 168) 1e-87 322 mutation to D: Lack of activity. 33 G 41 T 24142252 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt GABP_BACSU 39.3 10 441 2 429 Gamma-aminobutyric acid permease; GABA permease; 4-aminobutyrate permease; Gamma-aminobutyrate permease; Proline transporter GabP from Bacillus subtilis (strain 168) 1e-87 322 mutation to S: Lack of activity. 42 G 50 G 24142252 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt GABP_BACSU 39.3 10 441 2 429 Gamma-aminobutyric acid permease; GABA permease; 4-aminobutyrate permease; Gamma-aminobutyrate permease; Proline transporter GabP from Bacillus subtilis (strain 168) 1e-87 322 mutation to V: Lack of activity. 301 G 311 G 24142252 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt GABP_BACSU 39.3 10 441 2 429 Gamma-aminobutyric acid permease; GABA permease; 4-aminobutyrate permease; Gamma-aminobutyrate permease; Proline transporter GabP from Bacillus subtilis (strain 168) 1e-87 322 mutation to E: Lack of activity. 338 G 348 S 24142252 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt GABP_BACSU 39.3 10 441 2 429 Gamma-aminobutyric acid permease; GABA permease; 4-aminobutyrate permease; Gamma-aminobutyrate permease; Proline transporter GabP from Bacillus subtilis (strain 168) 1e-87 322 mutation to S: Lack of activity. 341 F 351 G 24142252 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt GABP_BACSU 39.3 10 441 2 429 Gamma-aminobutyric acid permease; GABA permease; 4-aminobutyrate permease; Gamma-aminobutyrate permease; Proline transporter GabP from Bacillus subtilis (strain 168) 1e-87 322 mutation to R: Lack of activity. 414 G 426 L 24142252 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt PHEP_ECOLI 38.1 2 415 5 412 Phenylalanine-specific permease; Phenylalanine:H(+) symporter PheP from Escherichia coli (strain K12) 9e-75 279 mutation R->G,S,Q: Strong decrease in phenylalanine transport activity. 26 R 23 R 8226700 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt PHEP_ECOLI 38.1 2 415 5 412 Phenylalanine-specific permease; Phenylalanine:H(+) symporter PheP from Escherichia coli (strain K12) 9e-75 279 mutation to A: 50% of wild-type phenylalanine transport activity.; mutation to G: No change in phenylalanine transport activity.; mutation to L: 26% of wild-type phenylalanine transport activity. 54 P 51 P 9791098 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt PHEP_ECOLI 38.1 2 415 5 412 Phenylalanine-specific permease; Phenylalanine:H(+) symporter PheP from Escherichia coli (strain K12) 9e-75 279 mutation to L: No effect on phenylalanine transport activity. 87 F 85 F 8226700 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt PHEP_ECOLI 38.1 2 415 5 412 Phenylalanine-specific permease; Phenylalanine:H(+) symporter PheP from Escherichia coli (strain K12) 9e-75 279 mutation to L: 65% of wild-type phenylalanine transport activity. 90 F 88 Y 8226700 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt PHEP_ECOLI 38.1 2 415 5 412 Phenylalanine-specific permease; Phenylalanine:H(+) symporter PheP from Escherichia coli (strain K12) 9e-75 279 mutation to L: 41% of wild-type phenylalanine transport activity. 92 Y 90 T 8226700 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt PHEP_ECOLI 38.1 2 415 5 412 Phenylalanine-specific permease; Phenylalanine:H(+) symporter PheP from Escherichia coli (strain K12) 9e-75 279 mutation to L: 69% of wild-type phenylalanine transport activity. 94 Y 92 Y 8226700 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt PHEP_ECOLI 38.1 2 415 5 412 Phenylalanine-specific permease; Phenylalanine:H(+) symporter PheP from Escherichia coli (strain K12) 9e-75 279 mutation to L: 10% of wild-type phenylalanine transport activity. 95 W 93 L 8226700 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt PHEP_ECOLI 38.1 2 415 5 412 Phenylalanine-specific permease; Phenylalanine:H(+) symporter PheP from Escherichia coli (strain K12) 9e-75 279 mutation to L: No effect on phenylalanine transport activity. 98 F 96 G 8226700 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt PHEP_ECOLI 38.1 2 415 5 412 Phenylalanine-specific permease; Phenylalanine:H(+) symporter PheP from Escherichia coli (strain K12) 9e-75 279 mutation to L: 38% of wild-type phenylalanine transport activity. 101 F 99 Y 8226700 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt PHEP_ECOLI 38.1 2 415 5 412 Phenylalanine-specific permease; Phenylalanine:H(+) symporter PheP from Escherichia coli (strain K12) 9e-75 279 mutation to L: 39% of wild-type phenylalanine transport activity. 105 W 103 W 8226700 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt PHEP_ECOLI 38.1 2 415 5 412 Phenylalanine-specific permease; Phenylalanine:H(+) symporter PheP from Escherichia coli (strain K12) 9e-75 279 mutation to L: No effect on phenylalanine transport activity. 107 Y 105 Y 8226700 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt PHEP_ECOLI 38.1 2 415 5 412 Phenylalanine-specific permease; Phenylalanine:H(+) symporter PheP from Escherichia coli (strain K12) 9e-75 279 mutation to L: 71% of wild-type phenylalanine transport activity. 108 W 106 W 8226700 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt PHEP_ECOLI 38.1 2 415 5 412 Phenylalanine-specific permease; Phenylalanine:H(+) symporter PheP from Escherichia coli (strain K12) 9e-75 279 mutation to L: 60% of wild-type phenylalanine transport activity.; mutation to Y: Enables the transport of tryptophan to... 111 F 109 W 10735864,8226700 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt PHEP_ECOLI 38.1 2 415 5 412 Phenylalanine-specific permease; Phenylalanine:H(+) symporter PheP from Escherichia coli (strain K12) 9e-75 279 mutation E->G,L,V,N: Loss of activity. 118 E 116 E 8226700 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt PHEP_ECOLI 38.1 2 415 5 412 Phenylalanine-specific permease; Phenylalanine:H(+) symporter PheP from Escherichia coli (strain K12) 9e-75 279 mutation K->L,R: Strong decrease in phenylalanine transport activity.; mutation to N: Loss of activity. 168 K 166 K 8226700 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt PHEP_ECOLI 38.1 2 415 5 412 Phenylalanine-specific permease; Phenylalanine:H(+) symporter PheP from Escherichia coli (strain K12) 9e-75 279 mutation E->A,Q,K,R,W: Loss of activity. 226 E 226 E 8226700 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt PHEP_ECOLI 38.1 2 415 5 412 Phenylalanine-specific permease; Phenylalanine:H(+) symporter PheP from Escherichia coli (strain K12) 9e-75 279 mutation R->D,E,F,W,P: Loss of activity. 252 R 252 R 8226700 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt PHEP_ECOLI 38.1 2 415 5 412 Phenylalanine-specific permease; Phenylalanine:H(+) symporter PheP from Escherichia coli (strain K12) 9e-75 279 mutation to A: 5% of wild-type phenylalanine transport activity.; mutation P->G,Q,K,R: Loss of activity.; mutation to S: 3% of wild-type phenylalanine transport activity.; mutation to T: 17% of wild-type phenylalanine transport activity. 341 P 341 P 9791098 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt PHEP_ECOLI 38.1 2 415 5 412 Phenylalanine-specific permease; Phenylalanine:H(+) symporter PheP from Escherichia coli (strain K12) 9e-75 279 P→A: 46% of wild-type phenylalanine transport activity.; P→G: 52% of wild-type phenylalanine transport activity.; P→L: 43% of wild-type phenylalanine transport activity. 442 9791098 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt AROP_ECOLI 36.0 14 394 9 386 Aromatic amino acid transport protein AroP; Aromatic amino acid:H(+) symporter AroP; General aromatic amino acid permease; General aromatic transport system from Escherichia coli (strain K12) 1e-70 265 Key residue for tryptophan transport; mutation to F: Decreases tryptophan transport to less than... 103 Y 109 W 10735864 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt CAN1_YEAST 31.0 17 464 85 551 Arginine permease CAN1; Canavanine resistance protein 1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 3e-59 228 mutation to L: In CAN1-343; confers citrulline transport activity... 113 P 45 T 11746604 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt CAN1_YEAST 31.0 17 464 85 551 Arginine permease CAN1; Canavanine resistance protein 1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 3e-59 228 mutation to L: In CAN1-337; confers citrulline transport activity... 148 P 80 P 11746604 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt CAN1_YEAST 31.0 17 464 85 551 Arginine permease CAN1; Canavanine resistance protein 1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 3e-59 228 mutation to F: In CAN1-315; confers citrulline transport activity... 149 V 81 E 11746604 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt CAN1_YEAST 31.0 17 464 85 551 Arginine permease CAN1; Canavanine resistance protein 1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 3e-59 228 mutation to F: In CAN1-342; confers citrulline transport activity... 152 S 84 S 11746604 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt CAN1_YEAST 31.0 17 464 85 551 Arginine permease CAN1; Canavanine resistance protein 1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 3e-59 228 mutation to D: In CAN1-306; confers citrulline transport activity...; mutation to H: In CAN1-327; confers citrulline transport activity... 173 Y 105 Y 11746604 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt CAN1_YEAST 31.0 17 464 85 551 Arginine permease CAN1; Canavanine resistance protein 1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 3e-59 228 mutation to A: In CAN1-341; confers citrulline transport activity... 308 G 233 G 11746604 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt CAN1_YEAST 31.0 17 464 85 551 Arginine permease CAN1; Canavanine resistance protein 1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 3e-59 228 mutation to S: In CAN1-329; confers citrulline transport activity... 313 P 238 P 11746604 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt CAN1_YEAST 31.0 17 464 85 551 Arginine permease CAN1; Canavanine resistance protein 1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 3e-59 228 mutation Missing: In CAN1-318; confers citrulline transport activity in... 354..355 TS -- 11746604 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt CAN1_YEAST 31.0 17 464 85 551 Arginine permease CAN1; Canavanine resistance protein 1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 3e-59 228 mutation to H: In CAN1-340; confers citrulline transport activity...; mutation to N: In CAN1-339; confers citrulline transport activity... 356 Y - 11746604 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt CAN1_YEAST 31.0 17 464 85 551 Arginine permease CAN1; Canavanine resistance protein 1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 3e-59 228 mutation to C: In CAN1-328; confers citrulline transport activity...; mutation to L: In CAN1-316; confers citrulline transport activity...; mutation to S: In CAN1-335; confers citrulline transport activity... 451 W 369 A 11746604 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt CAN1_YEAST 31.0 17 464 85 551 Arginine permease CAN1; Canavanine resistance protein 1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 3e-59 228 mutation to S: In CAN1-307; confers citrulline transport activity... 461 F 379 V 11746604 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt CAT1_SCHPO 30.8 17 408 81 481 Cationic amino acid transporter 1 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 2e-53 208 modified: Phosphoserine 29 18257517 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt CAT1_SCHPO 30.8 17 408 81 481 Cationic amino acid transporter 1 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 2e-53 208 modified: Phosphoserine 30 18257517 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt CAT1_SCHPO 30.8 17 408 81 481 Cationic amino acid transporter 1 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 2e-53 208 modified: Phosphoserine 37 18257517 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt GAP1_YEAST 32.1 17 409 87 491 General amino-acid permease GAP1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 1e-49 196 mutation to V: Impairs basic amino-acids transport and regulation... 297 A 223 S 21471002 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt GAP1_YEAST 32.1 17 409 87 491 General amino-acid permease GAP1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 1e-49 196 modified: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in... 76 12872131,14557538 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt GNP1_YEAST 27.6 4 409 133 550 High-affinity glutamine permease from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 4e-47 187 modified: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in... 132 12872131 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt SSY1_YEAST 21.8 8 425 269 761 SPS-sensor component SSY1; Amino-acid permease homolog SSY1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 6e-22 103 mutation T->H,L: Constitutively active, up-regulates amino acid permease transcription...; mutation to K: In SSY1-102; constitutively active, up-regulates amino...; mutation to R: Constitutively active, up-regulates amino acid permease... 382 T 122 I 14555474 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt PUUP_ECOLI 27.1 17 269 19 265 Putrescine importer PuuP from Escherichia coli (strain K12) 3e-11 68.2 mutation to X: The uptake activity is reduced to... 110 Y 109 W 19181795 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 6f34:A 23.0 11 424 18 421 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine. 1e-10 66.2 binding arginine 40 I 33 V 29416041 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 6f34:A 23.0 11 424 18 421 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine. 1e-10 66.2 binding arginine 42 G 35 G 29416041 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 6f34:A 23.0 11 424 18 421 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine. 1e-10 66.2 binding arginine 43 T 36 T 29416041 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 6f34:A 23.0 11 424 18 421 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine. 1e-10 66.2 binding arginine 44 G 37 G 29416041 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 6f34:A 23.0 11 424 18 421 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine. 1e-10 66.2 binding arginine 115 E 108 T 29416041 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 6f34:A 23.0 11 424 18 421 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine. 1e-10 66.2 binding arginine 116 Y 109 W 29416041 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 6f34:A 23.0 11 424 18 421 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine. 1e-10 66.2 binding arginine 119 A 112 A 29416041 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 6f34:A 23.0 11 424 18 421 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine. 1e-10 66.2 binding arginine 228 F 220 F 29416041 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 6f34:A 23.0 11 424 18 421 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine. 1e-10 66.2 binding arginine 229 A 221 A 29416041 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 6f34:A 23.0 11 424 18 421 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine. 1e-10 66.2 binding arginine 231 I 223 S 29416041 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 6f34:A 23.0 11 424 18 421 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine. 1e-10 66.2 binding arginine 314 V 307 A 29416041 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 6f34:A 23.0 11 424 18 421 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine. 1e-10 66.2 binding cholesterol 201 W 196 G 29416041 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 6f34:A 23.0 11 424 18 421 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine. 1e-10 66.2 binding cholesterol 202 Y 197 N 29416041 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 6f34:A 23.0 11 424 18 421 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine. 1e-10 66.2 binding peptide 28 G 21 Q 29416041 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 6f34:A 23.0 11 424 18 421 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine. 1e-10 66.2 binding peptide 30 F 23 R 29416041 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 6f34:A 23.0 11 424 18 421 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine. 1e-10 66.2 binding peptide 31 D 24 H 29416041 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 6f34:A 23.0 11 424 18 421 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine. 1e-10 66.2 binding peptide 34 M 27 M 29416041 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 6f34:A 23.0 11 424 18 421 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine. 1e-10 66.2 binding peptide 178 A 183 G 29416041 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 6f34:A 23.0 11 424 18 421 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine. 1e-10 66.2 binding peptide 179 R 184 G 29416041 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 6f34:A 23.0 11 424 18 421 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine. 1e-10 66.2 binding peptide 186 A 191 H 29416041 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 6f34:A 23.0 11 424 18 421 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine. 1e-10 66.2 binding peptide 187 I - 29416041 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 6f34:A 23.0 11 424 18 421 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine. 1e-10 66.2 binding peptide 190 A - 29416041 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 6f34:A 23.0 11 424 18 421 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine. 1e-10 66.2 binding peptide 194 L - 29416041 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 6f34:A 23.0 11 424 18 421 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine. 1e-10 66.2 binding peptide 296 Q 289 I 29416041 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 6f34:A 23.0 11 424 18 421 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine. 1e-10 66.2 binding peptide 299 V 292 A 29416041 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 5oqt:A 23.0 11 424 16 419 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue 3e-10 65.5 binding alanine 38 I 33 V 29416041 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 5oqt:A 23.0 11 424 16 419 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue 3e-10 65.5 binding alanine 40 G 35 G 29416041 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 5oqt:A 23.0 11 424 16 419 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue 3e-10 65.5 binding alanine 41 T 36 T 29416041 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 5oqt:A 23.0 11 424 16 419 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue 3e-10 65.5 binding alanine 42 G 37 G 29416041 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 5oqt:A 23.0 11 424 16 419 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue 3e-10 65.5 binding alanine 226 F 220 F 29416041 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 5oqt:A 23.0 11 424 16 419 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue 3e-10 65.5 binding alanine 227 A 221 A 29416041 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 5oqt:A 23.0 11 424 16 419 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue 3e-10 65.5 binding alanine 229 I 223 S 29416041 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 5oqt:A 23.0 11 424 16 419 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue 3e-10 65.5 binding peptide 24 E 19 D 29416041 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 5oqt:A 23.0 11 424 16 419 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue 3e-10 65.5 binding peptide 26 G 21 Q 29416041 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 5oqt:A 23.0 11 424 16 419 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue 3e-10 65.5 binding peptide 28 F 23 R 29416041 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 5oqt:A 23.0 11 424 16 419 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue 3e-10 65.5 binding peptide 29 D 24 H 29416041 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 5oqt:A 23.0 11 424 16 419 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue 3e-10 65.5 binding peptide 32 M 27 M 29416041 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 5oqt:A 23.0 11 424 16 419 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue 3e-10 65.5 binding peptide 176 A 183 G 29416041 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 5oqt:A 23.0 11 424 16 419 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue 3e-10 65.5 binding peptide 177 R 184 G 29416041 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 5oqt:A 23.0 11 424 16 419 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue 3e-10 65.5 binding peptide 184 A 191 H 29416041 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 5oqt:A 23.0 11 424 16 419 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue 3e-10 65.5 binding peptide 188 A - 29416041 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 5oqt:A 23.0 11 424 16 419 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue 3e-10 65.5 binding peptide 192 L - 29416041 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 5oqt:A 23.0 11 424 16 419 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue 3e-10 65.5 binding peptide 294 Q 289 I 29416041 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 5oqt:A 23.0 11 424 16 419 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue 3e-10 65.5 binding peptide 297 V 292 A 29416041 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt LAT2_MOUSE 22.1 30 359 49 381 Large neutral amino acids transporter small subunit 2; L-type amino acid transporter 2; mLAT2; Solute carrier family 7 member 8 from Mus musculus (Mouse) 3e-09 61.6 mutation to A: Increases T2 import. Increases T3 and... 130 Y - 28108384 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt LAT2_MOUSE 22.1 30 359 49 381 Large neutral amino acids transporter small subunit 2; L-type amino acid transporter 2; mLAT2; Solute carrier family 7 member 8 from Mus musculus (Mouse) 3e-09 61.6 mutation to S: Increases T2 import. Does not affect... 133 N 109 W 28108384 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt LAT2_MOUSE 22.1 30 359 49 381 Large neutral amino acids transporter small subunit 2; L-type amino acid transporter 2; mLAT2; Solute carrier family 7 member 8 from Mus musculus (Mouse) 3e-09 61.6 mutation to W: Increases T2 import. Does not affect... 242 F 220 F 28108384 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt ADIC_ECOLI 23.5 8 347 2 329 Arginine/agmatine antiporter from Escherichia coli (strain K12) 7e-09 60.5 binding ; binding 23 I 33 V 21368142,27582465 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt ADIC_ECOLI 23.5 8 347 2 329 Arginine/agmatine antiporter from Escherichia coli (strain K12) 7e-09 60.5 binding 26 S 36 T 21368142 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt ADIC_ECOLI 23.5 8 347 2 329 Arginine/agmatine antiporter from Escherichia coli (strain K12) 7e-09 60.5 mutation to L: Greatly decreased Arg uptake into liposomes. 93 Y 105 Y 19578361 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt ADIC_ECOLI 23.5 8 347 2 329 Arginine/agmatine antiporter from Escherichia coli (strain K12) 7e-09 60.5 binding ; binding 96 A - 21368142,27582465 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt ADIC_ECOLI 23.5 8 347 2 329 Arginine/agmatine antiporter from Escherichia coli (strain K12) 7e-09 60.5 binding 97 C 108 T 27582465 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt ADIC_ECOLI 23.5 8 347 2 329 Arginine/agmatine antiporter from Escherichia coli (strain K12) 7e-09 60.5 binding ; mutation to A: Vmax for Arg-Agm exchange 1% of...; mutation to D: Nearly wild-type Arg-Agm exchange. 101 N 112 A 21368142,27582465 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt ADIC_ECOLI 23.5 8 347 2 329 Arginine/agmatine antiporter from Escherichia coli (strain K12) 7e-09 60.5 binding ; mutation to A: 30% decreased affinity for Arg, 50%... 104 M 115 S 27582465 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt ADIC_ECOLI 23.5 8 347 2 329 Arginine/agmatine antiporter from Escherichia coli (strain K12) 7e-09 60.5 binding ; mutation to L: Halves Arg uptake into liposomes. 202 W 220 F 19578361,21368142 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt ADIC_ECOLI 23.5 8 347 2 329 Arginine/agmatine antiporter from Escherichia coli (strain K12) 7e-09 60.5 binding 203 S 221 A 27582465 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt ADIC_ECOLI 23.5 8 347 2 329 Arginine/agmatine antiporter from Escherichia coli (strain K12) 7e-09 60.5 binding ; binding ; mutation to A: About wild-type affinity for Arg and... 205 I 223 S 21368142,27582465 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt ADIC_ECOLI 23.5 8 347 2 329 Arginine/agmatine antiporter from Escherichia coli (strain K12) 7e-09 60.5 binding ; mutation W->C,H,L: Loss of Arg-Agm exchange.; mutation W->F,Y: Less than 20% Arg-Agm exchange activity. Vmax... 293 W 311 G 19578361,21368142,27582465 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt ADIC_ECOLI 23.5 8 347 2 329 Arginine/agmatine antiporter from Escherichia coli (strain K12) 7e-09 60.5 binding ; S→A: 20% decreased affinity for Arg, 40% decrease affinity... 357 21368142,27582465 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt ADIC_ECO57 23.5 8 347 2 329 Arginine/agmatine antiporter from Escherichia coli O157:H7 7e-09 60.5 mutation to A: No change in antiport activity, 6-fold... 22 N 32 G 19478139,20090677 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt ADIC_ECO57 23.5 8 347 2 329 Arginine/agmatine antiporter from Escherichia coli O157:H7 7e-09 60.5 binding 23 I 33 V 20090677 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt ADIC_ECO57 23.5 8 347 2 329 Arginine/agmatine antiporter from Escherichia coli O157:H7 7e-09 60.5 Helix-breaking GSG motif TM1 25..27 GSG 35..37 GTG 19478139,20090677 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt ADIC_ECO57 23.5 8 347 2 329 Arginine/agmatine antiporter from Escherichia coli O157:H7 7e-09 60.5 binding ; mutation to K: 5% Agm antiport. 26 S 36 T 19478139,20090677 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt ADIC_ECO57 23.5 8 347 2 329 Arginine/agmatine antiporter from Escherichia coli O157:H7 7e-09 60.5 binding 27 G 37 G 20090677 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt ADIC_ECO57 23.5 8 347 2 329 Arginine/agmatine antiporter from Escherichia coli O157:H7 7e-09 60.5 mutation to A: 50% antiport activity at pH 6.0,...; mutation Y->C,H,L,M,Q,S: Loss of pH-dependence of substrate transport.; mutation to F: Approximately wild-type antiport. 74 Y 86 S 25136114 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt ADIC_ECO57 23.5 8 347 2 329 Arginine/agmatine antiporter from Escherichia coli O157:H7 7e-09 60.5 mutation to A: Markedly reduced binding affinity for Agm... 87 Y 99 Y 19478139 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt ADIC_ECO57 23.5 8 347 2 329 Arginine/agmatine antiporter from Escherichia coli O157:H7 7e-09 60.5 mutation to A: Reduced binding affinity for Arg, no...; mutation to K: Almost no binding to both Arg... 93 Y 105 Y 19478139 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt ADIC_ECO57 23.5 8 347 2 329 Arginine/agmatine antiporter from Escherichia coli O157:H7 7e-09 60.5 binding 96 A - 20090677 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt ADIC_ECO57 23.5 8 347 2 329 Arginine/agmatine antiporter from Escherichia coli O157:H7 7e-09 60.5 binding 97 C 108 T 20090677 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt ADIC_ECO57 23.5 8 347 2 329 Arginine/agmatine antiporter from Escherichia coli O157:H7 7e-09 60.5 binding 101 N 112 A 20090677 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt ADIC_ECO57 23.5 8 347 2 329 Arginine/agmatine antiporter from Escherichia coli O157:H7 7e-09 60.5 binding ; Periplasmic (proximal) gate 202 W 220 F 20090677 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt ADIC_ECO57 23.5 8 347 2 329 Arginine/agmatine antiporter from Escherichia coli O157:H7 7e-09 60.5 binding 205 I 223 S 20090677 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt ADIC_ECO57 23.5 8 347 2 329 Arginine/agmatine antiporter from Escherichia coli O157:H7 7e-09 60.5 Helix-breaking GVESA motif TM6 206..210 GVESA 224..228 GTELI 19478139,20090677 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt ADIC_ECO57 23.5 8 347 2 329 Arginine/agmatine antiporter from Escherichia coli O157:H7 7e-09 60.5 mutation E->A,D: 5-10% Agm antiport. 208 E 226 E 19478139 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt ADIC_ECO57 23.5 8 347 2 329 Arginine/agmatine antiporter from Escherichia coli O157:H7 7e-09 60.5 binding 293 W 311 G 20090677 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt ADIC_ECO57 23.5 8 347 2 329 Arginine/agmatine antiporter from Escherichia coli O157:H7 7e-09 60.5 F→A: Severely decreased antiport. 337 25136114 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt ADIC_ECO57 23.5 8 347 2 329 Arginine/agmatine antiporter from Escherichia coli O157:H7 7e-09 60.5 binding 357 20090677 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt ADIC_ECO57 23.5 8 347 2 329 Arginine/agmatine antiporter from Escherichia coli O157:H7 7e-09 60.5 Y→A: Markedly weakened binding to Arg but not to... 365 19478139 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 5j4n:A 23.8 25 347 11 325 Crystal structure of the l-arginine/agmatine antiporter adic in complex with agmatine at 2.6 angstroem resolution 7e-09 60.5 binding agmatine 19 I 33 V 27582465 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 5j4n:A 23.8 25 347 11 325 Crystal structure of the l-arginine/agmatine antiporter adic in complex with agmatine at 2.6 angstroem resolution 7e-09 60.5 binding agmatine 92 A - 27582465 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 5j4n:A 23.8 25 347 11 325 Crystal structure of the l-arginine/agmatine antiporter adic in complex with agmatine at 2.6 angstroem resolution 7e-09 60.5 binding agmatine 93 C 108 T 27582465 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 5j4n:A 23.8 25 347 11 325 Crystal structure of the l-arginine/agmatine antiporter adic in complex with agmatine at 2.6 angstroem resolution 7e-09 60.5 binding agmatine 96 G 111 V 27582465 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 5j4n:A 23.8 25 347 11 325 Crystal structure of the l-arginine/agmatine antiporter adic in complex with agmatine at 2.6 angstroem resolution 7e-09 60.5 binding agmatine 97 N 112 A 27582465 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 5j4n:A 23.8 25 347 11 325 Crystal structure of the l-arginine/agmatine antiporter adic in complex with agmatine at 2.6 angstroem resolution 7e-09 60.5 binding agmatine 100 M 115 S 27582465 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 5j4n:A 23.8 25 347 11 325 Crystal structure of the l-arginine/agmatine antiporter adic in complex with agmatine at 2.6 angstroem resolution 7e-09 60.5 binding agmatine 289 W 311 G 27582465 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt LAT2_HUMAN 21.5 30 359 50 382 Large neutral amino acids transporter small subunit 2; L-type amino acid transporter 2; hLAT2; Solute carrier family 7 member 8 from Homo sapiens (Human) 1e-08 60.1 binding 53 I 33 V 33298890 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt LAT2_HUMAN 21.5 30 359 50 382 Large neutral amino acids transporter small subunit 2; L-type amino acid transporter 2; hLAT2; Solute carrier family 7 member 8 from Homo sapiens (Human) 1e-08 60.1 mutation to A: Nearly complete reduction of glycine, L-alanine,... 93 Y 72 L 34848541 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt LAT2_HUMAN 21.5 30 359 50 382 Large neutral amino acids transporter small subunit 2; L-type amino acid transporter 2; hLAT2; Solute carrier family 7 member 8 from Homo sapiens (Human) 1e-08 60.1 binding ; Important for substrate specificity; mutation to Q: Reduces L-leucine uptake activity. Abolishes L-tryptophan...; mutation to S: The substrate specificity changed dramatically reducing... 134 N 109 W 33298890,34848541 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt LAT2_HUMAN 21.5 30 359 50 382 Large neutral amino acids transporter small subunit 2; L-type amino acid transporter 2; hLAT2; Solute carrier family 7 member 8 from Homo sapiens (Human) 1e-08 60.1 modified: Interchain (with C-210 in SLC3A2) 154 C 126 R 33298890,34848541 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt LAT2_HUMAN 21.5 30 359 50 382 Large neutral amino acids transporter small subunit 2; L-type amino acid transporter 2; hLAT2; Solute carrier family 7 member 8 from Homo sapiens (Human) 1e-08 60.1 mutation to A: Does not affect protein expression, plasma... 174 W 146 I 34848541 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt LAT2_HUMAN 21.5 30 359 50 382 Large neutral amino acids transporter small subunit 2; L-type amino acid transporter 2; hLAT2; Solute carrier family 7 member 8 from Homo sapiens (Human) 1e-08 60.1 mutation to A: Abolishes leucine and tryptophan transport activities. 243 F 220 F 33298890 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt LAT2_HUMAN 21.5 30 359 50 382 Large neutral amino acids transporter small subunit 2; L-type amino acid transporter 2; hLAT2; Solute carrier family 7 member 8 from Homo sapiens (Human) 1e-08 60.1 binding ; Important for substrate specificity; mutation to S: Strong decrease in the uptake of... 246 G 223 S 33298890,34848541 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt LAT2_HUMAN 21.5 30 359 50 382 Large neutral amino acids transporter small subunit 2; L-type amino acid transporter 2; hLAT2; Solute carrier family 7 member 8 from Homo sapiens (Human) 1e-08 60.1 to I: found in a patient with age-related hearing... 302 V 278 S 29355479 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt LAT2_HUMAN 21.5 30 359 50 382 Large neutral amino acids transporter small subunit 2; L-type amino acid transporter 2; hLAT2; Solute carrier family 7 member 8 from Homo sapiens (Human) 1e-08 60.1 binding ; N→Q: Strongly reduces L-leucine uptake activity. Strongly reduces L-tryptophan... 395 33298890 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt LAT2_HUMAN 21.5 30 359 50 382 Large neutral amino acids transporter small subunit 2; L-type amino acid transporter 2; hLAT2; Solute carrier family 7 member 8 from Homo sapiens (Human) 1e-08 60.1 Y→A: Strongly reduces L-leucine uptake activity. 396 33298890 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt LAT2_HUMAN 21.5 30 359 50 382 Large neutral amino acids transporter small subunit 2; L-type amino acid transporter 2; hLAT2; Solute carrier family 7 member 8 from Homo sapiens (Human) 1e-08 60.1 T → M: found in a patient with age-related... 402 29355479 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt LAT2_HUMAN 21.5 30 359 50 382 Large neutral amino acids transporter small subunit 2; L-type amino acid transporter 2; hLAT2; Solute carrier family 7 member 8 from Homo sapiens (Human) 1e-08 60.1 R → C: found in a patient with age-related... 418 29355479 PP_0660 PP_0660 S-methyl-L-methionine transporter SwissProt LAT2_HUMAN 21.5 30 359 50 382 Large neutral amino acids transporter small subunit 2; L-type amino acid transporter 2; hLAT2; Solute carrier family 7 member 8 from Homo sapiens (Human) 1e-08 60.1 V → E: found in a patient with age-related... 460 29355479 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 7b00:A 21.5 30 359 10 342 Human lat2-4f2hc complex in the apo-state 1e-08 60.1 binding Digitonin 338 M 355 S 34848541 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 7b00:A 21.5 30 359 10 342 Human lat2-4f2hc complex in the apo-state 1e-08 60.1 binding Digitonin 350 34848541 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 7b00:A 21.5 30 359 10 342 Human lat2-4f2hc complex in the apo-state 1e-08 60.1 binding Digitonin 408 34848541 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 7b00:A 21.5 30 359 10 342 Human lat2-4f2hc complex in the apo-state 1e-08 60.1 binding Digitonin 411 34848541 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 7cmi:B 21.5 30 359 10 342 The lat2-4f2hc complex in complex with leucine 1e-08 60.1 binding leucine 13 I 33 V 33298890 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 7cmi:B 21.5 30 359 10 342 The lat2-4f2hc complex in complex with leucine 1e-08 60.1 binding leucine 15 G 35 G 33298890 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 7cmi:B 21.5 30 359 10 342 The lat2-4f2hc complex in complex with leucine 1e-08 60.1 binding leucine 17 G 37 G 33298890 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 7cmi:B 21.5 30 359 10 342 The lat2-4f2hc complex in complex with leucine 1e-08 60.1 binding leucine 94 N 109 W 33298890 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 7cmi:B 21.5 30 359 10 342 The lat2-4f2hc complex in complex with leucine 1e-08 60.1 binding leucine 203 F 220 F 33298890 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 7cmi:B 21.5 30 359 10 342 The lat2-4f2hc complex in complex with leucine 1e-08 60.1 binding leucine 206 G 223 S 33298890 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 7cmh:B 21.5 30 359 10 342 The lat2-4f2hc complex in complex with tryptophan 1e-08 60.1 binding tryptophan 15 G 35 G 33298890 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 7cmh:B 21.5 30 359 10 342 The lat2-4f2hc complex in complex with tryptophan 1e-08 60.1 binding tryptophan 17 G 37 G 33298890 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 7cmh:B 21.5 30 359 10 342 The lat2-4f2hc complex in complex with tryptophan 1e-08 60.1 binding tryptophan 94 N 109 W 33298890 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 7cmh:B 21.5 30 359 10 342 The lat2-4f2hc complex in complex with tryptophan 1e-08 60.1 binding tryptophan 203 F 220 F 33298890 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 7cmh:B 21.5 30 359 10 342 The lat2-4f2hc complex in complex with tryptophan 1e-08 60.1 binding tryptophan 204 A 221 A 33298890 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 7cmh:B 21.5 30 359 10 342 The lat2-4f2hc complex in complex with tryptophan 1e-08 60.1 binding tryptophan 206 G 223 S 33298890 PP_0660 PP_0660 S-methyl-L-methionine transporter PDB 7cmh:B 21.5 30 359 10 342 The lat2-4f2hc complex in complex with tryptophan 1e-08 60.1 binding tryptophan 355 33298890