queryId subjectDb subjectId identity queryAlnBegin queryAlnEnd sujectAlnBegin subjectAlnEnd subjectDescription evalue bits subjectSite subjectSiteRange subjectSiteSeq querySiteRange querySiteSeq pubMedIds PP_1743 PP_1743 acetate permease SwissProt PUTP_ECOLI 26.5 42 484 7 462 Sodium/proline symporter; Proline carrier; Proline permease; Propionate transporter from Escherichia coli (strain K12) 3e-19 95.1 mutation to C: Sodium-independent binding affinity for proline. 257 R 288 R 3053649 PP_1743 PP_1743 acetate permease SwissProt PUTP_ECOLI 26.5 42 484 7 462 Sodium/proline symporter; Proline carrier; Proline permease; Propionate transporter from Escherichia coli (strain K12) 3e-19 95.1 mutation to S: Does not affect proline uptake activity.... 281 C 316 T 1567896,3053687 PP_1743 PP_1743 acetate permease SwissProt PUTP_ECOLI 26.5 42 484 7 462 Sodium/proline symporter; Proline carrier; Proline permease; Propionate transporter from Escherichia coli (strain K12) 3e-19 95.1 mutation to S: Small decrease in proline uptake activity.... 344 C 378 G 1567896,3053687 PP_1743 PP_1743 acetate permease SwissProt PUTP_ECOLI 26.5 42 484 7 462 Sodium/proline symporter; Proline carrier; Proline permease; Propionate transporter from Escherichia coli (strain K12) 3e-19 95.1 mutation to S: Does not affect proline uptake activity.... 349 C 383 G 1567896,3053687 PP_1743 PP_1743 acetate permease SwissProt PUTP_ECOLI 26.5 42 484 7 462 Sodium/proline symporter; Proline carrier; Proline permease; Propionate transporter from Escherichia coli (strain K12) 3e-19 95.1 mutation R->E,Q: No change in activity.; mutation to K: Loss of activity. 376 R 411 K 8119910 PP_1743 PP_1743 acetate permease PDB 5nv9:A 21.9 58 336 25 304 Substrate-bound outward-open state of a na+-coupled sialic acid symporter reveals a novel na+-site 2e-09 62.4 binding sodium ion 52 A 85 G 29717135 PP_1743 PP_1743 acetate permease PDB 5nv9:A 21.9 58 336 25 304 Substrate-bound outward-open state of a na+-coupled sialic acid symporter reveals a novel na+-site 2e-09 62.4 binding sodium ion 53 T 86 D 29717135 PP_1743 PP_1743 acetate permease PDB 5nv9:A 21.9 58 336 25 304 Substrate-bound outward-open state of a na+-coupled sialic acid symporter reveals a novel na+-site 2e-09 62.4 binding sodium ion 55 L 88 M 29717135 PP_1743 PP_1743 acetate permease PDB 5nv9:A 21.9 58 336 25 304 Substrate-bound outward-open state of a na+-coupled sialic acid symporter reveals a novel na+-site 2e-09 62.4 binding sodium ion 56 S 89 S 29717135 PP_1743 PP_1743 acetate permease PDB 5nv9:A 21.9 58 336 25 304 Substrate-bound outward-open state of a na+-coupled sialic acid symporter reveals a novel na+-site 2e-09 62.4 binding sodium ion 174 V 208 T 29717135 PP_1743 PP_1743 acetate permease PDB 5nv9:A 21.9 58 336 25 304 Substrate-bound outward-open state of a na+-coupled sialic acid symporter reveals a novel na+-site 2e-09 62.4 binding sodium ion 178 D 212 Q 29717135 PP_1743 PP_1743 acetate permease PDB 5nv9:A 21.9 58 336 25 304 Substrate-bound outward-open state of a na+-coupled sialic acid symporter reveals a novel na+-site 2e-09 62.4 binding N-acetyl-beta-neuraminic acid 54 T 87 Y 29717135 PP_1743 PP_1743 acetate permease PDB 5nv9:A 21.9 58 336 25 304 Substrate-bound outward-open state of a na+-coupled sialic acid symporter reveals a novel na+-site 2e-09 62.4 binding N-acetyl-beta-neuraminic acid 56 S 89 S 29717135 PP_1743 PP_1743 acetate permease PDB 5nv9:A 21.9 58 336 25 304 Substrate-bound outward-open state of a na+-coupled sialic acid symporter reveals a novel na+-site 2e-09 62.4 binding N-acetyl-beta-neuraminic acid 58 I 91 A 29717135 PP_1743 PP_1743 acetate permease PDB 5nv9:A 21.9 58 336 25 304 Substrate-bound outward-open state of a na+-coupled sialic acid symporter reveals a novel na+-site 2e-09 62.4 binding N-acetyl-beta-neuraminic acid 59 T 92 S 29717135 PP_1743 PP_1743 acetate permease PDB 5nv9:A 21.9 58 336 25 304 Substrate-bound outward-open state of a na+-coupled sialic acid symporter reveals a novel na+-site 2e-09 62.4 binding N-acetyl-beta-neuraminic acid 77 G 110 Y 29717135 PP_1743 PP_1743 acetate permease PDB 5nv9:A 21.9 58 336 25 304 Substrate-bound outward-open state of a na+-coupled sialic acid symporter reveals a novel na+-site 2e-09 62.4 binding N-acetyl-beta-neuraminic acid 78 Q 111 S 29717135 PP_1743 PP_1743 acetate permease PDB 5nv9:A 21.9 58 336 25 304 Substrate-bound outward-open state of a na+-coupled sialic acid symporter reveals a novel na+-site 2e-09 62.4 binding N-acetyl-beta-neuraminic acid 131 R 166 L 29717135 PP_1743 PP_1743 acetate permease PDB 5nv9:A 21.9 58 336 25 304 Substrate-bound outward-open state of a na+-coupled sialic acid symporter reveals a novel na+-site 2e-09 62.4 binding N-acetyl-beta-neuraminic acid 239 F - 29717135 PP_1743 PP_1743 acetate permease PDB 5nv9:A 21.9 58 336 25 304 Substrate-bound outward-open state of a na+-coupled sialic acid symporter reveals a novel na+-site 2e-09 62.4 binding sodium ion 335 29717135 PP_1743 PP_1743 acetate permease PDB 5nv9:A 21.9 58 336 25 304 Substrate-bound outward-open state of a na+-coupled sialic acid symporter reveals a novel na+-site 2e-09 62.4 binding sodium ion 338 29717135 PP_1743 PP_1743 acetate permease PDB 5nv9:A 21.9 58 336 25 304 Substrate-bound outward-open state of a na+-coupled sialic acid symporter reveals a novel na+-site 2e-09 62.4 binding sodium ion 338 29717135 PP_1743 PP_1743 acetate permease PDB 5nv9:A 21.9 58 336 25 304 Substrate-bound outward-open state of a na+-coupled sialic acid symporter reveals a novel na+-site 2e-09 62.4 binding sodium ion 339 29717135 PP_1743 PP_1743 acetate permease PDB 5nv9:A 21.9 58 336 25 304 Substrate-bound outward-open state of a na+-coupled sialic acid symporter reveals a novel na+-site 2e-09 62.4 binding sodium ion 341 29717135 PP_1743 PP_1743 acetate permease PDB 5nv9:A 21.9 58 336 25 304 Substrate-bound outward-open state of a na+-coupled sialic acid symporter reveals a novel na+-site 2e-09 62.4 binding sodium ion 342 29717135 PP_1743 PP_1743 acetate permease SwissProt SC5A5_HUMAN 24.6 42 222 19 201 Sodium/iodide cotransporter; Na(+)/I(-) cotransporter; Natrium iodide transporter; Sodium-iodide symporter; Na(+)/I(-) symporter; Solute carrier family 5 member 5 from Homo sapiens (Human) 1e-06 53.5 natural variant: A -> P 102 A 122 L 9329364 PP_1743 PP_1743 acetate permease SwissProt SC5A5_HUMAN 24.6 42 222 19 201 Sodium/iodide cotransporter; Na(+)/I(-) cotransporter; Natrium iodide transporter; Sodium-iodide symporter; Na(+)/I(-) symporter; Solute carrier family 5 member 5 from Homo sapiens (Human) 1e-06 53.5 mutation H->A,D,E,K: Significant loss of iodide transport activity but... 226 18708479 PP_1743 PP_1743 acetate permease SwissProt SC5A5_HUMAN 24.6 42 222 19 201 Sodium/iodide cotransporter; Na(+)/I(-) cotransporter; Natrium iodide transporter; Sodium-iodide symporter; Na(+)/I(-) symporter; Solute carrier family 5 member 5 from Homo sapiens (Human) 1e-06 53.5 D→A: Loss of localization to the cell membrane, significant... 237 31310151 PP_1743 PP_1743 acetate permease SwissProt SC5A5_HUMAN 24.6 42 222 19 201 Sodium/iodide cotransporter; Na(+)/I(-) cotransporter; Natrium iodide transporter; Sodium-iodide symporter; Na(+)/I(-) symporter; Solute carrier family 5 member 5 from Homo sapiens (Human) 1e-06 53.5 Required for homodimerization; Y→A: Loss of localization to the cell membrane, significant... 242 31310151 PP_1743 PP_1743 acetate permease SwissProt SC5A5_HUMAN 24.6 42 222 19 201 Sodium/iodide cotransporter; Na(+)/I(-) cotransporter; Natrium iodide transporter; Sodium-iodide symporter; Na(+)/I(-) symporter; Solute carrier family 5 member 5 from Homo sapiens (Human) 1e-06 53.5 Required for homodimerization; T→A: Loss of localization to the cell membrane, significant... 243 31310151 PP_1743 PP_1743 acetate permease SwissProt SC5A5_HUMAN 24.6 42 222 19 201 Sodium/iodide cotransporter; Na(+)/I(-) cotransporter; Natrium iodide transporter; Sodium-iodide symporter; Na(+)/I(-) symporter; Solute carrier family 5 member 5 from Homo sapiens (Human) 1e-06 53.5 Required for homodimerization; Q→A: No effect on localization to the cell membrane,... 471 31310151 PP_1743 PP_1743 acetate permease SwissProt SC5A5_HUMAN 24.6 42 222 19 201 Sodium/iodide cotransporter; Na(+)/I(-) cotransporter; Natrium iodide transporter; Sodium-iodide symporter; Na(+)/I(-) symporter; Solute carrier family 5 member 5 from Homo sapiens (Human) 1e-06 53.5 A→F: Loss of localization to the cell membrane, significant... 525 31310151 PP_1743 PP_1743 acetate permease SwissProt SC5A5_HUMAN 24.6 42 222 19 201 Sodium/iodide cotransporter; Na(+)/I(-) cotransporter; Natrium iodide transporter; Sodium-iodide symporter; Na(+)/I(-) symporter; Solute carrier family 5 member 5 from Homo sapiens (Human) 1e-06 53.5 T → Q: requires 2 nucleotide substitutions 536 9329364 PP_1743 PP_1743 acetate permease SwissProt SC5A5_HUMAN 24.6 42 222 19 201 Sodium/iodide cotransporter; Na(+)/I(-) cotransporter; Natrium iodide transporter; Sodium-iodide symporter; Na(+)/I(-) symporter; Solute carrier family 5 member 5 from Homo sapiens (Human) 1e-06 53.5 S → Q: requires 2 nucleotide substitutions 556 9329364 PP_1743 PP_1743 acetate permease SwissProt SC5A1_RABIT 18.7 29 482 18 501 Sodium/glucose cotransporter 1; Na(+)/glucose cotransporter 1; High affinity sodium-glucose cotransporter; Solute carrier family 5 member 1 from Oryctolagus cuniculus (Rabbit) 6e-05 48.1 modified: Disulfide link with 608 255 C 261 L 17616521 PP_1743 PP_1743 acetate permease SwissProt SC5A1_RABIT 18.7 29 482 18 501 Sodium/glucose cotransporter 1; Na(+)/glucose cotransporter 1; High affinity sodium-glucose cotransporter; Solute carrier family 5 member 1 from Oryctolagus cuniculus (Rabbit) 6e-05 48.1 mutation to W: Drasticly decreased affinity for glucose and... 457 Q 441 F 20692230 PP_1743 PP_1743 acetate permease SwissProt SC5A1_RABIT 18.7 29 482 18 501 Sodium/glucose cotransporter 1; Na(+)/glucose cotransporter 1; High affinity sodium-glucose cotransporter; Solute carrier family 5 member 1 from Oryctolagus cuniculus (Rabbit) 6e-05 48.1 mutation to W: Decreased affinity for glucose and phlorizin. 460 T 444 A 20692230 PP_1743 PP_1743 acetate permease SwissProt SC5A1_RABIT 18.7 29 482 18 501 Sodium/glucose cotransporter 1; Na(+)/glucose cotransporter 1; High affinity sodium-glucose cotransporter; Solute carrier family 5 member 1 from Oryctolagus cuniculus (Rabbit) 6e-05 48.1 modified: Disulfide link with 255 608 17616521