queryId subjectDb subjectId identity queryAlnBegin queryAlnEnd sujectAlnBegin subjectAlnEnd subjectDescription evalue bits subjectSite subjectSiteRange subjectSiteSeq querySiteRange querySiteSeq pubMedIds PfGW456L13_318 Histidine transport protein (permease) SwissProt PHEP_ECOLI 45.3 2 447 13 454 Phenylalanine-specific permease; Phenylalanine:H(+) symporter PheP from Escherichia coli (strain K12) 1e-107 387 mutation R->G,S,Q: Strong decrease in phenylalanine transport activity. 26 R 15 R 8226700 PfGW456L13_318 Histidine transport protein (permease) SwissProt PHEP_ECOLI 45.3 2 447 13 454 Phenylalanine-specific permease; Phenylalanine:H(+) symporter PheP from Escherichia coli (strain K12) 1e-107 387 mutation to A: 50% of wild-type phenylalanine transport activity.; mutation to G: No change in phenylalanine transport activity.; mutation to L: 26% of wild-type phenylalanine transport activity. 54 P 43 P 9791098 PfGW456L13_318 Histidine transport protein (permease) SwissProt PHEP_ECOLI 45.3 2 447 13 454 Phenylalanine-specific permease; Phenylalanine:H(+) symporter PheP from Escherichia coli (strain K12) 1e-107 387 mutation to L: No effect on phenylalanine transport activity. 87 F 76 F 8226700 PfGW456L13_318 Histidine transport protein (permease) SwissProt PHEP_ECOLI 45.3 2 447 13 454 Phenylalanine-specific permease; Phenylalanine:H(+) symporter PheP from Escherichia coli (strain K12) 1e-107 387 mutation to L: 65% of wild-type phenylalanine transport activity. 90 F 79 Y 8226700 PfGW456L13_318 Histidine transport protein (permease) SwissProt PHEP_ECOLI 45.3 2 447 13 454 Phenylalanine-specific permease; Phenylalanine:H(+) symporter PheP from Escherichia coli (strain K12) 1e-107 387 mutation to L: 41% of wild-type phenylalanine transport activity. 92 Y 81 S 8226700 PfGW456L13_318 Histidine transport protein (permease) SwissProt PHEP_ECOLI 45.3 2 447 13 454 Phenylalanine-specific permease; Phenylalanine:H(+) symporter PheP from Escherichia coli (strain K12) 1e-107 387 mutation to L: 69% of wild-type phenylalanine transport activity. 94 Y 83 Y 8226700 PfGW456L13_318 Histidine transport protein (permease) SwissProt PHEP_ECOLI 45.3 2 447 13 454 Phenylalanine-specific permease; Phenylalanine:H(+) symporter PheP from Escherichia coli (strain K12) 1e-107 387 mutation to L: 10% of wild-type phenylalanine transport activity. 95 W 84 L 8226700 PfGW456L13_318 Histidine transport protein (permease) SwissProt PHEP_ECOLI 45.3 2 447 13 454 Phenylalanine-specific permease; Phenylalanine:H(+) symporter PheP from Escherichia coli (strain K12) 1e-107 387 mutation to L: No effect on phenylalanine transport activity. 98 F 87 M 8226700 PfGW456L13_318 Histidine transport protein (permease) SwissProt PHEP_ECOLI 45.3 2 447 13 454 Phenylalanine-specific permease; Phenylalanine:H(+) symporter PheP from Escherichia coli (strain K12) 1e-107 387 mutation to L: 38% of wild-type phenylalanine transport activity. 101 F 90 F 8226700 PfGW456L13_318 Histidine transport protein (permease) SwissProt PHEP_ECOLI 45.3 2 447 13 454 Phenylalanine-specific permease; Phenylalanine:H(+) symporter PheP from Escherichia coli (strain K12) 1e-107 387 mutation to L: 39% of wild-type phenylalanine transport activity. 105 W 94 W 8226700 PfGW456L13_318 Histidine transport protein (permease) SwissProt PHEP_ECOLI 45.3 2 447 13 454 Phenylalanine-specific permease; Phenylalanine:H(+) symporter PheP from Escherichia coli (strain K12) 1e-107 387 mutation to L: No effect on phenylalanine transport activity. 107 Y 96 Y 8226700 PfGW456L13_318 Histidine transport protein (permease) SwissProt PHEP_ECOLI 45.3 2 447 13 454 Phenylalanine-specific permease; Phenylalanine:H(+) symporter PheP from Escherichia coli (strain K12) 1e-107 387 mutation to L: 71% of wild-type phenylalanine transport activity. 108 W 97 A 8226700 PfGW456L13_318 Histidine transport protein (permease) SwissProt PHEP_ECOLI 45.3 2 447 13 454 Phenylalanine-specific permease; Phenylalanine:H(+) symporter PheP from Escherichia coli (strain K12) 1e-107 387 mutation to L: 60% of wild-type phenylalanine transport activity.; mutation to Y: Enables the transport of tryptophan to... 111 F 100 M 10735864,8226700 PfGW456L13_318 Histidine transport protein (permease) SwissProt PHEP_ECOLI 45.3 2 447 13 454 Phenylalanine-specific permease; Phenylalanine:H(+) symporter PheP from Escherichia coli (strain K12) 1e-107 387 mutation E->G,L,V,N: Loss of activity. 118 E 107 D 8226700 PfGW456L13_318 Histidine transport protein (permease) SwissProt PHEP_ECOLI 45.3 2 447 13 454 Phenylalanine-specific permease; Phenylalanine:H(+) symporter PheP from Escherichia coli (strain K12) 1e-107 387 mutation K->L,R: Strong decrease in phenylalanine transport activity.; mutation to N: Loss of activity. 168 K 157 K 8226700 PfGW456L13_318 Histidine transport protein (permease) SwissProt PHEP_ECOLI 45.3 2 447 13 454 Phenylalanine-specific permease; Phenylalanine:H(+) symporter PheP from Escherichia coli (strain K12) 1e-107 387 mutation E->A,Q,K,R,W: Loss of activity. 226 E 218 E 8226700 PfGW456L13_318 Histidine transport protein (permease) SwissProt PHEP_ECOLI 45.3 2 447 13 454 Phenylalanine-specific permease; Phenylalanine:H(+) symporter PheP from Escherichia coli (strain K12) 1e-107 387 mutation R->D,E,F,W,P: Loss of activity. 252 R 244 R 8226700 PfGW456L13_318 Histidine transport protein (permease) SwissProt PHEP_ECOLI 45.3 2 447 13 454 Phenylalanine-specific permease; Phenylalanine:H(+) symporter PheP from Escherichia coli (strain K12) 1e-107 387 mutation to A: 5% of wild-type phenylalanine transport activity.; mutation P->G,Q,K,R: Loss of activity.; mutation to S: 3% of wild-type phenylalanine transport activity.; mutation to T: 17% of wild-type phenylalanine transport activity. 341 P 333 P 9791098 PfGW456L13_318 Histidine transport protein (permease) SwissProt PHEP_ECOLI 45.3 2 447 13 454 Phenylalanine-specific permease; Phenylalanine:H(+) symporter PheP from Escherichia coli (strain K12) 1e-107 387 mutation to A: 46% of wild-type phenylalanine transport activity.; mutation to G: 52% of wild-type phenylalanine transport activity.; mutation to L: 43% of wild-type phenylalanine transport activity. 442 P 435 V 9791098 PfGW456L13_318 Histidine transport protein (permease) SwissProt AROP_ECOLI 44.5 2 457 5 456 Aromatic amino acid transport protein AroP; Aromatic amino acid:H(+) symporter AroP; General aromatic amino acid permease; General aromatic transport system from Escherichia coli (strain K12) 1e-104 378 Key residue for tryptophan transport; mutation to F: Decreases tryptophan transport to less than... 103 Y 100 M 10735864 PfGW456L13_318 Histidine transport protein (permease) SwissProt GABP_BACSU 33.7 1 464 1 466 Gamma-aminobutyric acid permease; GABA permease; 4-aminobutyrate permease; Gamma-aminobutyrate permease; Proline transporter GabP from Bacillus subtilis (strain 168) 1e-76 285 mutation to D: Lack of activity. 33 G 33 G 24142252 PfGW456L13_318 Histidine transport protein (permease) SwissProt GABP_BACSU 33.7 1 464 1 466 Gamma-aminobutyric acid permease; GABA permease; 4-aminobutyrate permease; Gamma-aminobutyrate permease; Proline transporter GabP from Bacillus subtilis (strain 168) 1e-76 285 mutation to S: Lack of activity. 42 G 42 G 24142252 PfGW456L13_318 Histidine transport protein (permease) SwissProt GABP_BACSU 33.7 1 464 1 466 Gamma-aminobutyric acid permease; GABA permease; 4-aminobutyrate permease; Gamma-aminobutyrate permease; Proline transporter GabP from Bacillus subtilis (strain 168) 1e-76 285 mutation to V: Lack of activity. 301 G 303 D 24142252 PfGW456L13_318 Histidine transport protein (permease) SwissProt GABP_BACSU 33.7 1 464 1 466 Gamma-aminobutyric acid permease; GABA permease; 4-aminobutyrate permease; Gamma-aminobutyrate permease; Proline transporter GabP from Bacillus subtilis (strain 168) 1e-76 285 mutation to E: Lack of activity. 338 G 340 M 24142252 PfGW456L13_318 Histidine transport protein (permease) SwissProt GABP_BACSU 33.7 1 464 1 466 Gamma-aminobutyric acid permease; GABA permease; 4-aminobutyrate permease; Gamma-aminobutyrate permease; Proline transporter GabP from Bacillus subtilis (strain 168) 1e-76 285 mutation to S: Lack of activity. 341 F 343 A 24142252 PfGW456L13_318 Histidine transport protein (permease) SwissProt GABP_BACSU 33.7 1 464 1 466 Gamma-aminobutyric acid permease; GABA permease; 4-aminobutyrate permease; Gamma-aminobutyrate permease; Proline transporter GabP from Bacillus subtilis (strain 168) 1e-76 285 mutation to R: Lack of activity. 414 G 416 F 24142252 PfGW456L13_318 Histidine transport protein (permease) SwissProt LYSP_ECOLI 35.1 7 417 12 431 Lysine-specific permease LysP; Lysine transporter LysP; Trigger transporter LysP from Escherichia coli (strain K12) 1e-60 232 mutation to L: Retains 4% of wild-type lysine uptake... 102 Y 96 Y 24056175 PfGW456L13_318 Histidine transport protein (permease) SwissProt LYSP_ECOLI 35.1 7 417 12 431 Lysine-specific permease LysP; Lysine transporter LysP; Trigger transporter LysP from Escherichia coli (strain K12) 1e-60 232 mutation to L: Retains 20% of wild-type lysine uptake... 106 W 100 M 24056175 PfGW456L13_318 Histidine transport protein (permease) SwissProt LYSP_ECOLI 35.1 7 417 12 431 Lysine-specific permease LysP; Lysine transporter LysP; Trigger transporter LysP from Escherichia coli (strain K12) 1e-60 232 mutation to A: Retains 24% of wild-type lysine uptake... 163 K 157 K 24056175 PfGW456L13_318 Histidine transport protein (permease) SwissProt LYSP_ECOLI 35.1 7 417 12 431 Lysine-specific permease LysP; Lysine transporter LysP; Trigger transporter LysP from Escherichia coli (strain K12) 1e-60 232 mutation to L: Retains 13% of wild-type lysine uptake... 216 F 212 F 24056175 PfGW456L13_318 Histidine transport protein (permease) SwissProt LYSP_ECOLI 35.1 7 417 12 431 Lysine-specific permease LysP; Lysine transporter LysP; Trigger transporter LysP from Escherichia coli (strain K12) 1e-60 232 mutation to A: Abolishes lysine uptake. Strongly inhibits CadC. 222 E 218 E 24056175 PfGW456L13_318 Histidine transport protein (permease) SwissProt LYSP_ECOLI 35.1 7 417 12 431 Lysine-specific permease LysP; Lysine transporter LysP; Trigger transporter LysP from Escherichia coli (strain K12) 1e-60 232 mutation to V: Abolishes lysine uptake. Shows significant less... 230 E 226 E 24056175 PfGW456L13_318 Histidine transport protein (permease) SwissProt LYSP_ECOLI 35.1 7 417 12 431 Lysine-specific permease LysP; Lysine transporter LysP; Trigger transporter LysP from Escherichia coli (strain K12) 1e-60 232 Essential for the stimulus-dependent interaction with CadC; mutation to A: Retains 88% of wild-type lysine uptake... 275 D - 24056175 PfGW456L13_318 Histidine transport protein (permease) SwissProt LYSP_ECOLI 35.1 7 417 12 431 Lysine-specific permease LysP; Lysine transporter LysP; Trigger transporter LysP from Escherichia coli (strain K12) 1e-60 232 Essential for the stimulus-dependent interaction with CadC; mutation to A: Retains 88% of wild-type lysine uptake... 278 D 266 G 24056175 PfGW456L13_318 Histidine transport protein (permease) SwissProt LYSP_ECOLI 35.1 7 417 12 431 Lysine-specific permease LysP; Lysine transporter LysP; Trigger transporter LysP from Escherichia coli (strain K12) 1e-60 232 modified: Initiator methionine, Removed 1 7551055 PfGW456L13_318 Histidine transport protein (permease) SwissProt LYSP_ECOLI 35.1 7 417 12 431 Lysine-specific permease LysP; Lysine transporter LysP; Trigger transporter LysP from Escherichia coli (strain K12) 1e-60 232 E→A: Retains 14% of wild-type lysine uptake activity. Is... 438 24056175 PfGW456L13_318 Histidine transport protein (permease) SwissProt LYSP_ECOLI 35.1 7 417 12 431 Lysine-specific permease LysP; Lysine transporter LysP; Trigger transporter LysP from Escherichia coli (strain K12) 1e-60 232 D→A: Retains 11% of wild-type lysine uptake activity. Is... 443 24056175 PfGW456L13_318 Histidine transport protein (permease) SwissProt LYSP_ECOLI 35.1 7 417 12 431 Lysine-specific permease LysP; Lysine transporter LysP; Trigger transporter LysP from Escherichia coli (strain K12) 1e-60 232 D→A: Retains 13% of wild-type lysine uptake activity. Is... 446 24056175 PfGW456L13_318 Histidine transport protein (permease) SwissProt CAN1_YEAST 31.8 8 423 84 515 Arginine permease CAN1; Canavanine resistance protein 1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 1e-47 189 mutation to L: In CAN1-343; confers citrulline transport activity... 113 P 37 A 11746604 PfGW456L13_318 Histidine transport protein (permease) SwissProt CAN1_YEAST 31.8 8 423 84 515 Arginine permease CAN1; Canavanine resistance protein 1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 1e-47 189 mutation to L: In CAN1-337; confers citrulline transport activity... 148 P 71 P 11746604 PfGW456L13_318 Histidine transport protein (permease) SwissProt CAN1_YEAST 31.8 8 423 84 515 Arginine permease CAN1; Canavanine resistance protein 1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 1e-47 189 mutation to F: In CAN1-315; confers citrulline transport activity... 149 V 72 V 11746604 PfGW456L13_318 Histidine transport protein (permease) SwissProt CAN1_YEAST 31.8 8 423 84 515 Arginine permease CAN1; Canavanine resistance protein 1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 1e-47 189 mutation to F: In CAN1-342; confers citrulline transport activity... 152 S 75 S 11746604 PfGW456L13_318 Histidine transport protein (permease) SwissProt CAN1_YEAST 31.8 8 423 84 515 Arginine permease CAN1; Canavanine resistance protein 1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 1e-47 189 mutation to D: In CAN1-306; confers citrulline transport activity...; mutation to H: In CAN1-327; confers citrulline transport activity... 173 Y 96 Y 11746604 PfGW456L13_318 Histidine transport protein (permease) SwissProt CAN1_YEAST 31.8 8 423 84 515 Arginine permease CAN1; Canavanine resistance protein 1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 1e-47 189 mutation to A: In CAN1-341; confers citrulline transport activity... 308 G 225 G 11746604 PfGW456L13_318 Histidine transport protein (permease) SwissProt CAN1_YEAST 31.8 8 423 84 515 Arginine permease CAN1; Canavanine resistance protein 1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 1e-47 189 mutation to S: In CAN1-329; confers citrulline transport activity... 313 P 230 P 11746604 PfGW456L13_318 Histidine transport protein (permease) SwissProt CAN1_YEAST 31.8 8 423 84 515 Arginine permease CAN1; Canavanine resistance protein 1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 1e-47 189 mutation Missing: In CAN1-318; confers citrulline transport activity in... 354..355 TS 266..267 GS 11746604 PfGW456L13_318 Histidine transport protein (permease) SwissProt CAN1_YEAST 31.8 8 423 84 515 Arginine permease CAN1; Canavanine resistance protein 1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 1e-47 189 mutation to H: In CAN1-340; confers citrulline transport activity...; mutation to N: In CAN1-339; confers citrulline transport activity... 356 Y - 11746604 PfGW456L13_318 Histidine transport protein (permease) SwissProt CAN1_YEAST 31.8 8 423 84 515 Arginine permease CAN1; Canavanine resistance protein 1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 1e-47 189 mutation to C: In CAN1-328; confers citrulline transport activity...; mutation to L: In CAN1-316; confers citrulline transport activity...; mutation to S: In CAN1-335; confers citrulline transport activity... 451 W 361 L 11746604 PfGW456L13_318 Histidine transport protein (permease) SwissProt CAN1_YEAST 31.8 8 423 84 515 Arginine permease CAN1; Canavanine resistance protein 1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 1e-47 189 mutation to S: In CAN1-307; confers citrulline transport activity... 461 F 371 V 11746604 PfGW456L13_318 Histidine transport protein (permease) SwissProt CAT1_SCHPO 30.8 8 402 80 485 Cationic amino acid transporter 1 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 3e-43 174 modified: Phosphoserine 29 18257517 PfGW456L13_318 Histidine transport protein (permease) SwissProt CAT1_SCHPO 30.8 8 402 80 485 Cationic amino acid transporter 1 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 3e-43 174 modified: Phosphoserine 30 18257517 PfGW456L13_318 Histidine transport protein (permease) SwissProt CAT1_SCHPO 30.8 8 402 80 485 Cationic amino acid transporter 1 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 3e-43 174 modified: Phosphoserine 37 18257517 PfGW456L13_318 Histidine transport protein (permease) SwissProt GAP1_YEAST 28.9 8 401 86 493 General amino-acid permease GAP1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 4e-38 157 mutation to V: Impairs basic amino-acids transport and regulation... 297 A 215 G 21471002 PfGW456L13_318 Histidine transport protein (permease) SwissProt GAP1_YEAST 28.9 8 401 86 493 General amino-acid permease GAP1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 4e-38 157 modified: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in... 76 12872131,14557538 PfGW456L13_318 Histidine transport protein (permease) SwissProt GNP1_YEAST 25.7 1 391 138 540 High-affinity glutamine permease from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 7e-37 153 modified: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in... 132 12872131 PfGW456L13_318 Histidine transport protein (permease) SwissProt SSY1_YEAST 22.7 8 422 277 762 SPS-sensor component SSY1; Amino-acid permease homolog SSY1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 2e-21 102 mutation T->H,L: Constitutively active, up-regulates amino acid permease transcription...; mutation to K: In SSY1-102; constitutively active, up-regulates amino...; mutation to R: Constitutively active, up-regulates amino acid permease... 382 T 112 G 14555474 PfGW456L13_318 Histidine transport protein (permease) SwissProt STET_BACSU 23.0 1 419 1 405 Serine/threonine exchanger SteT from Bacillus subtilis (strain 168) 2e-16 85.5 mutation to S: Retains 25% of the transport activity;... 94 C 92 L 17344220 PfGW456L13_318 Histidine transport protein (permease) SwissProt STET_BACSU 23.0 1 419 1 405 Serine/threonine exchanger SteT from Bacillus subtilis (strain 168) 2e-16 85.5 mutation to S: Retains 25% of the transport activity;... 141 C 141 C 17344220 PfGW456L13_318 Histidine transport protein (permease) SwissProt STET_BACSU 23.0 1 419 1 405 Serine/threonine exchanger SteT from Bacillus subtilis (strain 168) 2e-16 85.5 mutation to S: Retains 25% of the transport activity;... 168 C 163 A 17344220 PfGW456L13_318 Histidine transport protein (permease) SwissProt STET_BACSU 23.0 1 419 1 405 Serine/threonine exchanger SteT from Bacillus subtilis (strain 168) 2e-16 85.5 mutation to S: Retains 25% of the transport activity;... 291 C 299 A 17344220 PfGW456L13_318 Histidine transport protein (permease) SwissProt STET_BACSU 23.0 1 419 1 405 Serine/threonine exchanger SteT from Bacillus subtilis (strain 168) 2e-16 85.5 C→S: Retains 25% of the transport activity; when associated... 415 17344220 PfGW456L13_318 Histidine transport protein (permease) PDB 6f34:A 22.7 36 413 52 420 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine. 1e-14 79.7 binding arginine 115 E 99 E 29416041 PfGW456L13_318 Histidine transport protein (permease) PDB 6f34:A 22.7 36 413 52 420 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine. 1e-14 79.7 binding arginine 116 Y 100 M 29416041 PfGW456L13_318 Histidine transport protein (permease) PDB 6f34:A 22.7 36 413 52 420 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine. 1e-14 79.7 binding arginine 119 A 103 V 29416041 PfGW456L13_318 Histidine transport protein (permease) PDB 6f34:A 22.7 36 413 52 420 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine. 1e-14 79.7 binding arginine 228 F 212 F 29416041 PfGW456L13_318 Histidine transport protein (permease) PDB 6f34:A 22.7 36 413 52 420 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine. 1e-14 79.7 binding arginine 229 A 213 A 29416041 PfGW456L13_318 Histidine transport protein (permease) PDB 6f34:A 22.7 36 413 52 420 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine. 1e-14 79.7 binding arginine 231 I 215 G 29416041 PfGW456L13_318 Histidine transport protein (permease) PDB 6f34:A 22.7 36 413 52 420 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine. 1e-14 79.7 binding arginine 314 V 299 A 29416041 PfGW456L13_318 Histidine transport protein (permease) PDB 6f34:A 22.7 36 413 52 420 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine. 1e-14 79.7 binding cholesterol 201 W 173 W 29416041 PfGW456L13_318 Histidine transport protein (permease) PDB 6f34:A 22.7 36 413 52 420 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine. 1e-14 79.7 binding cholesterol 202 Y 174 F 29416041 PfGW456L13_318 Histidine transport protein (permease) PDB 6f34:A 22.7 36 413 52 420 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine. 1e-14 79.7 binding peptide 178 A 149 M 29416041 PfGW456L13_318 Histidine transport protein (permease) PDB 6f34:A 22.7 36 413 52 420 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine. 1e-14 79.7 binding peptide 179 R 150 E 29416041 PfGW456L13_318 Histidine transport protein (permease) PDB 6f34:A 22.7 36 413 52 420 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine. 1e-14 79.7 binding peptide 186 A 157 K 29416041 PfGW456L13_318 Histidine transport protein (permease) PDB 6f34:A 22.7 36 413 52 420 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine. 1e-14 79.7 binding peptide 187 I 158 V 29416041 PfGW456L13_318 Histidine transport protein (permease) PDB 6f34:A 22.7 36 413 52 420 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine. 1e-14 79.7 binding peptide 190 A 161 I 29416041 PfGW456L13_318 Histidine transport protein (permease) PDB 6f34:A 22.7 36 413 52 420 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine. 1e-14 79.7 binding peptide 194 L 165 I 29416041 PfGW456L13_318 Histidine transport protein (permease) PDB 6f34:A 22.7 36 413 52 420 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine. 1e-14 79.7 binding peptide 296 Q 281 I 29416041 PfGW456L13_318 Histidine transport protein (permease) PDB 6f34:A 22.7 36 413 52 420 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine. 1e-14 79.7 binding peptide 299 V 284 A 29416041 PfGW456L13_318 Histidine transport protein (permease) PDB 6f34:A 22.7 36 413 52 420 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine. 1e-14 79.7 binding arginine 40 29416041 PfGW456L13_318 Histidine transport protein (permease) PDB 6f34:A 22.7 36 413 52 420 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine. 1e-14 79.7 binding arginine 42 29416041 PfGW456L13_318 Histidine transport protein (permease) PDB 6f34:A 22.7 36 413 52 420 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine. 1e-14 79.7 binding arginine 43 29416041 PfGW456L13_318 Histidine transport protein (permease) PDB 6f34:A 22.7 36 413 52 420 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine. 1e-14 79.7 binding arginine 44 29416041 PfGW456L13_318 Histidine transport protein (permease) PDB 6f34:A 22.7 36 413 52 420 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine. 1e-14 79.7 binding peptide 28 29416041 PfGW456L13_318 Histidine transport protein (permease) PDB 6f34:A 22.7 36 413 52 420 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine. 1e-14 79.7 binding peptide 30 29416041 PfGW456L13_318 Histidine transport protein (permease) PDB 6f34:A 22.7 36 413 52 420 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine. 1e-14 79.7 binding peptide 31 29416041 PfGW456L13_318 Histidine transport protein (permease) PDB 6f34:A 22.7 36 413 52 420 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine. 1e-14 79.7 binding peptide 34 29416041 PfGW456L13_318 Histidine transport protein (permease) PDB 5oqt:A 22.7 36 413 50 418 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue 4e-14 78.2 binding alanine 226 F 212 F 29416041 PfGW456L13_318 Histidine transport protein (permease) PDB 5oqt:A 22.7 36 413 50 418 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue 4e-14 78.2 binding alanine 227 A 213 A 29416041 PfGW456L13_318 Histidine transport protein (permease) PDB 5oqt:A 22.7 36 413 50 418 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue 4e-14 78.2 binding alanine 229 I 215 G 29416041 PfGW456L13_318 Histidine transport protein (permease) PDB 5oqt:A 22.7 36 413 50 418 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue 4e-14 78.2 binding peptide 176 A 149 M 29416041 PfGW456L13_318 Histidine transport protein (permease) PDB 5oqt:A 22.7 36 413 50 418 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue 4e-14 78.2 binding peptide 177 R 150 E 29416041 PfGW456L13_318 Histidine transport protein (permease) PDB 5oqt:A 22.7 36 413 50 418 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue 4e-14 78.2 binding peptide 184 A 157 K 29416041 PfGW456L13_318 Histidine transport protein (permease) PDB 5oqt:A 22.7 36 413 50 418 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue 4e-14 78.2 binding peptide 188 A 161 I 29416041 PfGW456L13_318 Histidine transport protein (permease) PDB 5oqt:A 22.7 36 413 50 418 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue 4e-14 78.2 binding peptide 192 L 165 I 29416041 PfGW456L13_318 Histidine transport protein (permease) PDB 5oqt:A 22.7 36 413 50 418 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue 4e-14 78.2 binding peptide 294 Q 281 I 29416041 PfGW456L13_318 Histidine transport protein (permease) PDB 5oqt:A 22.7 36 413 50 418 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue 4e-14 78.2 binding peptide 297 V 284 A 29416041 PfGW456L13_318 Histidine transport protein (permease) PDB 5oqt:A 22.7 36 413 50 418 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue 4e-14 78.2 binding alanine 38 29416041 PfGW456L13_318 Histidine transport protein (permease) PDB 5oqt:A 22.7 36 413 50 418 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue 4e-14 78.2 binding alanine 40 29416041 PfGW456L13_318 Histidine transport protein (permease) PDB 5oqt:A 22.7 36 413 50 418 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue 4e-14 78.2 binding alanine 41 29416041 PfGW456L13_318 Histidine transport protein (permease) PDB 5oqt:A 22.7 36 413 50 418 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue 4e-14 78.2 binding alanine 42 29416041 PfGW456L13_318 Histidine transport protein (permease) PDB 5oqt:A 22.7 36 413 50 418 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue 4e-14 78.2 binding peptide 24 29416041 PfGW456L13_318 Histidine transport protein (permease) PDB 5oqt:A 22.7 36 413 50 418 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue 4e-14 78.2 binding peptide 26 29416041 PfGW456L13_318 Histidine transport protein (permease) PDB 5oqt:A 22.7 36 413 50 418 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue 4e-14 78.2 binding peptide 28 29416041 PfGW456L13_318 Histidine transport protein (permease) PDB 5oqt:A 22.7 36 413 50 418 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue 4e-14 78.2 binding peptide 29 29416041 PfGW456L13_318 Histidine transport protein (permease) PDB 5oqt:A 22.7 36 413 50 418 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue 4e-14 78.2 binding peptide 32 29416041 PfGW456L13_318 Histidine transport protein (permease) SwissProt PUUP_ECOLI 26.0 3 238 12 242 Putrescine importer PuuP from Escherichia coli (strain K12) 2e-13 75.9 mutation to X: The uptake activity is reduced to... 110 Y 100 M 19181795 PfGW456L13_318 Histidine transport protein (permease) SwissProt CTR1_HUMAN 23.0 2 333 22 385 High affinity cationic amino acid transporter 1; CAT-1; CAT1; Ecotropic retroviral leukemia receptor homolog; Ecotropic retrovirus receptor homolog; Solute carrier family 7 member 1; System Y+ basic amino acid transporter from Homo sapiens (Human) 9e-12 70.1 modified: carbohydrate, N-linked (GlcNAc...) asparagine 226 N 188 N 19349973 PfGW456L13_318 Histidine transport protein (permease) PDB 6f2w:A 23.6 20 417 12 398 Bacterial asc transporter crystal structure in open to in conformation 1e-08 59.7 binding alpha-aminoisobutyric acid 17 V 25 A 31000719 PfGW456L13_318 Histidine transport protein (permease) PDB 6f2w:A 23.6 20 417 12 398 Bacterial asc transporter crystal structure in open to in conformation 1e-08 59.7 binding alpha-aminoisobutyric acid 19 G 27 G 31000719 PfGW456L13_318 Histidine transport protein (permease) PDB 6f2w:A 23.6 20 417 12 398 Bacterial asc transporter crystal structure in open to in conformation 1e-08 59.7 binding alpha-aminoisobutyric acid 20 A 28 T 31000719 PfGW456L13_318 Histidine transport protein (permease) PDB 6f2w:A 23.6 20 417 12 398 Bacterial asc transporter crystal structure in open to in conformation 1e-08 59.7 binding alpha-aminoisobutyric acid 21 G 29 G 31000719 PfGW456L13_318 Histidine transport protein (permease) PDB 6f2w:A 23.6 20 417 12 398 Bacterial asc transporter crystal structure in open to in conformation 1e-08 59.7 binding alpha-aminoisobutyric acid 199 F 212 F 31000719 PfGW456L13_318 Histidine transport protein (permease) PDB 6f2w:A 23.6 20 417 12 398 Bacterial asc transporter crystal structure in open to in conformation 1e-08 59.7 binding alpha-aminoisobutyric acid 200 A 213 A 31000719 PfGW456L13_318 Histidine transport protein (permease) PDB 6f2w:A 23.6 20 417 12 398 Bacterial asc transporter crystal structure in open to in conformation 1e-08 59.7 binding alpha-aminoisobutyric acid 202 D 215 G 31000719 PfGW456L13_318 Histidine transport protein (permease) PDB 5j4n:A 22.8 17 333 11 319 Crystal structure of the l-arginine/agmatine antiporter adic in complex with agmatine at 2.6 angstroem resolution 5e-08 57.8 binding agmatine 19 I 25 A 27582465 PfGW456L13_318 Histidine transport protein (permease) PDB 5j4n:A 22.8 17 333 11 319 Crystal structure of the l-arginine/agmatine antiporter adic in complex with agmatine at 2.6 angstroem resolution 5e-08 57.8 binding agmatine 92 A 92 L 27582465 PfGW456L13_318 Histidine transport protein (permease) PDB 5j4n:A 22.8 17 333 11 319 Crystal structure of the l-arginine/agmatine antiporter adic in complex with agmatine at 2.6 angstroem resolution 5e-08 57.8 binding agmatine 93 C 93 G 27582465 PfGW456L13_318 Histidine transport protein (permease) PDB 5j4n:A 22.8 17 333 11 319 Crystal structure of the l-arginine/agmatine antiporter adic in complex with agmatine at 2.6 angstroem resolution 5e-08 57.8 binding agmatine 96 G 96 Y 27582465 PfGW456L13_318 Histidine transport protein (permease) PDB 5j4n:A 22.8 17 333 11 319 Crystal structure of the l-arginine/agmatine antiporter adic in complex with agmatine at 2.6 angstroem resolution 5e-08 57.8 binding agmatine 97 N 97 A 27582465 PfGW456L13_318 Histidine transport protein (permease) PDB 5j4n:A 22.8 17 333 11 319 Crystal structure of the l-arginine/agmatine antiporter adic in complex with agmatine at 2.6 angstroem resolution 5e-08 57.8 binding agmatine 100 M 100 M 27582465 PfGW456L13_318 Histidine transport protein (permease) PDB 5j4n:A 22.8 17 333 11 319 Crystal structure of the l-arginine/agmatine antiporter adic in complex with agmatine at 2.6 angstroem resolution 5e-08 57.8 binding agmatine 289 W 303 D 27582465 PfGW456L13_318 Histidine transport protein (permease) SwissProt ADIC_ECOLI 22.8 17 333 15 323 Arginine/agmatine antiporter from Escherichia coli (strain K12) 6e-08 57.4 binding ; binding 23 I 25 A 21368142,27582465 PfGW456L13_318 Histidine transport protein (permease) SwissProt ADIC_ECOLI 22.8 17 333 15 323 Arginine/agmatine antiporter from Escherichia coli (strain K12) 6e-08 57.4 binding 26 S 28 T 21368142 PfGW456L13_318 Histidine transport protein (permease) SwissProt ADIC_ECOLI 22.8 17 333 15 323 Arginine/agmatine antiporter from Escherichia coli (strain K12) 6e-08 57.4 mutation to L: Greatly decreased Arg uptake into liposomes. 93 Y - 19578361 PfGW456L13_318 Histidine transport protein (permease) SwissProt ADIC_ECOLI 22.8 17 333 15 323 Arginine/agmatine antiporter from Escherichia coli (strain K12) 6e-08 57.4 binding ; binding 96 A 92 L 21368142,27582465 PfGW456L13_318 Histidine transport protein (permease) SwissProt ADIC_ECOLI 22.8 17 333 15 323 Arginine/agmatine antiporter from Escherichia coli (strain K12) 6e-08 57.4 binding 97 C 93 G 27582465 PfGW456L13_318 Histidine transport protein (permease) SwissProt ADIC_ECOLI 22.8 17 333 15 323 Arginine/agmatine antiporter from Escherichia coli (strain K12) 6e-08 57.4 binding ; mutation to A: Vmax for Arg-Agm exchange 1% of...; mutation to D: Nearly wild-type Arg-Agm exchange. 101 N 97 A 21368142,27582465 PfGW456L13_318 Histidine transport protein (permease) SwissProt ADIC_ECOLI 22.8 17 333 15 323 Arginine/agmatine antiporter from Escherichia coli (strain K12) 6e-08 57.4 binding ; mutation to A: 30% decreased affinity for Arg, 50%... 104 M 100 M 27582465 PfGW456L13_318 Histidine transport protein (permease) SwissProt ADIC_ECOLI 22.8 17 333 15 323 Arginine/agmatine antiporter from Escherichia coli (strain K12) 6e-08 57.4 binding ; mutation to L: Halves Arg uptake into liposomes. 202 W 212 F 19578361,21368142 PfGW456L13_318 Histidine transport protein (permease) SwissProt ADIC_ECOLI 22.8 17 333 15 323 Arginine/agmatine antiporter from Escherichia coli (strain K12) 6e-08 57.4 binding 203 S 213 A 27582465 PfGW456L13_318 Histidine transport protein (permease) SwissProt ADIC_ECOLI 22.8 17 333 15 323 Arginine/agmatine antiporter from Escherichia coli (strain K12) 6e-08 57.4 binding ; binding ; mutation to A: About wild-type affinity for Arg and... 205 I 215 G 21368142,27582465 PfGW456L13_318 Histidine transport protein (permease) SwissProt ADIC_ECOLI 22.8 17 333 15 323 Arginine/agmatine antiporter from Escherichia coli (strain K12) 6e-08 57.4 binding ; mutation W->C,H,L: Loss of Arg-Agm exchange.; mutation W->F,Y: Less than 20% Arg-Agm exchange activity. Vmax... 293 W 303 D 19578361,21368142,27582465 PfGW456L13_318 Histidine transport protein (permease) SwissProt ADIC_ECOLI 22.8 17 333 15 323 Arginine/agmatine antiporter from Escherichia coli (strain K12) 6e-08 57.4 binding ; S→A: 20% decreased affinity for Arg, 40% decrease affinity... 357 21368142,27582465 PfGW456L13_318 Histidine transport protein (permease) SwissProt ADIC_ECO57 22.8 17 333 15 323 Arginine/agmatine antiporter from Escherichia coli O157:H7 6e-08 57.4 mutation to A: No change in antiport activity, 6-fold... 22 N 24 S 19478139,20090677 PfGW456L13_318 Histidine transport protein (permease) SwissProt ADIC_ECO57 22.8 17 333 15 323 Arginine/agmatine antiporter from Escherichia coli O157:H7 6e-08 57.4 binding 23 I 25 A 20090677 PfGW456L13_318 Histidine transport protein (permease) SwissProt ADIC_ECO57 22.8 17 333 15 323 Arginine/agmatine antiporter from Escherichia coli O157:H7 6e-08 57.4 Helix-breaking GSG motif TM1 25..27 GSG 27..29 GTG 19478139,20090677 PfGW456L13_318 Histidine transport protein (permease) SwissProt ADIC_ECO57 22.8 17 333 15 323 Arginine/agmatine antiporter from Escherichia coli O157:H7 6e-08 57.4 binding ; mutation to K: 5% Agm antiport. 26 S 28 T 19478139,20090677 PfGW456L13_318 Histidine transport protein (permease) SwissProt ADIC_ECO57 22.8 17 333 15 323 Arginine/agmatine antiporter from Escherichia coli O157:H7 6e-08 57.4 binding 27 G 29 G 20090677 PfGW456L13_318 Histidine transport protein (permease) SwissProt ADIC_ECO57 22.8 17 333 15 323 Arginine/agmatine antiporter from Escherichia coli O157:H7 6e-08 57.4 mutation to A: 50% antiport activity at pH 6.0,...; mutation Y->C,H,L,M,Q,S: Loss of pH-dependence of substrate transport.; mutation to F: Approximately wild-type antiport. 74 Y 77 G 25136114 PfGW456L13_318 Histidine transport protein (permease) SwissProt ADIC_ECO57 22.8 17 333 15 323 Arginine/agmatine antiporter from Escherichia coli O157:H7 6e-08 57.4 mutation to A: Markedly reduced binding affinity for Agm... 87 Y 90 F 19478139 PfGW456L13_318 Histidine transport protein (permease) SwissProt ADIC_ECO57 22.8 17 333 15 323 Arginine/agmatine antiporter from Escherichia coli O157:H7 6e-08 57.4 mutation to A: Reduced binding affinity for Arg, no...; mutation to K: Almost no binding to both Arg... 93 Y - 19478139 PfGW456L13_318 Histidine transport protein (permease) SwissProt ADIC_ECO57 22.8 17 333 15 323 Arginine/agmatine antiporter from Escherichia coli O157:H7 6e-08 57.4 binding 96 A 92 L 20090677 PfGW456L13_318 Histidine transport protein (permease) SwissProt ADIC_ECO57 22.8 17 333 15 323 Arginine/agmatine antiporter from Escherichia coli O157:H7 6e-08 57.4 binding 97 C 93 G 20090677 PfGW456L13_318 Histidine transport protein (permease) SwissProt ADIC_ECO57 22.8 17 333 15 323 Arginine/agmatine antiporter from Escherichia coli O157:H7 6e-08 57.4 binding 101 N 97 A 20090677 PfGW456L13_318 Histidine transport protein (permease) SwissProt ADIC_ECO57 22.8 17 333 15 323 Arginine/agmatine antiporter from Escherichia coli O157:H7 6e-08 57.4 binding ; Periplasmic (proximal) gate 202 W 212 F 20090677 PfGW456L13_318 Histidine transport protein (permease) SwissProt ADIC_ECO57 22.8 17 333 15 323 Arginine/agmatine antiporter from Escherichia coli O157:H7 6e-08 57.4 binding 205 I 215 G 20090677 PfGW456L13_318 Histidine transport protein (permease) SwissProt ADIC_ECO57 22.8 17 333 15 323 Arginine/agmatine antiporter from Escherichia coli O157:H7 6e-08 57.4 Helix-breaking GVESA motif TM6 206..210 GVESA 216..220 GIEII 19478139,20090677 PfGW456L13_318 Histidine transport protein (permease) SwissProt ADIC_ECO57 22.8 17 333 15 323 Arginine/agmatine antiporter from Escherichia coli O157:H7 6e-08 57.4 mutation E->A,D: 5-10% Agm antiport. 208 E 218 E 19478139 PfGW456L13_318 Histidine transport protein (permease) SwissProt ADIC_ECO57 22.8 17 333 15 323 Arginine/agmatine antiporter from Escherichia coli O157:H7 6e-08 57.4 binding 293 W 303 D 20090677 PfGW456L13_318 Histidine transport protein (permease) SwissProt ADIC_ECO57 22.8 17 333 15 323 Arginine/agmatine antiporter from Escherichia coli O157:H7 6e-08 57.4 F→A: Severely decreased antiport. 337 25136114 PfGW456L13_318 Histidine transport protein (permease) SwissProt ADIC_ECO57 22.8 17 333 15 323 Arginine/agmatine antiporter from Escherichia coli O157:H7 6e-08 57.4 binding 357 20090677 PfGW456L13_318 Histidine transport protein (permease) SwissProt ADIC_ECO57 22.8 17 333 15 323 Arginine/agmatine antiporter from Escherichia coli O157:H7 6e-08 57.4 Y→A: Markedly weakened binding to Arg but not to... 365 19478139 PfGW456L13_318 Histidine transport protein (permease) PDB 3l1l:A 23.0 17 333 9 306 Structure of arg-bound escherichia coli adic 2e-07 55.5 binding arginine 17 I 25 A 20090677 PfGW456L13_318 Histidine transport protein (permease) PDB 3l1l:A 23.0 17 333 9 306 Structure of arg-bound escherichia coli adic 2e-07 55.5 binding arginine 20 S 28 T 20090677 PfGW456L13_318 Histidine transport protein (permease) PDB 3l1l:A 23.0 17 333 9 306 Structure of arg-bound escherichia coli adic 2e-07 55.5 binding arginine 21 G 29 G 20090677 PfGW456L13_318 Histidine transport protein (permease) PDB 3l1l:A 23.0 17 333 9 306 Structure of arg-bound escherichia coli adic 2e-07 55.5 binding arginine 94 G 96 Y 20090677 PfGW456L13_318 Histidine transport protein (permease) PDB 3l1l:A 23.0 17 333 9 306 Structure of arg-bound escherichia coli adic 2e-07 55.5 binding arginine 95 N 97 A 20090677 PfGW456L13_318 Histidine transport protein (permease) PDB 3l1l:A 23.0 17 333 9 306 Structure of arg-bound escherichia coli adic 2e-07 55.5 binding arginine 185 W 212 F 20090677 PfGW456L13_318 Histidine transport protein (permease) PDB 3l1l:A 23.0 17 333 9 306 Structure of arg-bound escherichia coli adic 2e-07 55.5 binding arginine 186 S 213 A 20090677 PfGW456L13_318 Histidine transport protein (permease) PDB 3l1l:A 23.0 17 333 9 306 Structure of arg-bound escherichia coli adic 2e-07 55.5 binding arginine 188 I 215 G 20090677 PfGW456L13_318 Histidine transport protein (permease) PDB 3l1l:A 23.0 17 333 9 306 Structure of arg-bound escherichia coli adic 2e-07 55.5 binding arginine 276 W 303 D 20090677 PfGW456L13_318 Histidine transport protein (permease) SwissProt LAT1_HUMAN 22.2 185 403 223 438 Large neutral amino acids transporter small subunit 1; 4F2 light chain; 4F2 LC; 4F2LC; CD98 light chain; Integral membrane protein E16; E16; L-type amino acid transporter 1; hLAT1; Solute carrier family 7 member 5; y+ system cationic amino acid transporter from Homo sapiens (Human) 8e-05 47.0 to V: in dbSNP:rs17853937 223 D 185 D 15489334 PfGW456L13_318 Histidine transport protein (permease) SwissProt LAT1_HUMAN 22.2 185 403 223 438 Large neutral amino acids transporter small subunit 1; 4F2 light chain; 4F2 LC; 4F2LC; CD98 light chain; Integral membrane protein E16; E16; L-type amino acid transporter 1; hLAT1; Solute carrier family 7 member 5; y+ system cationic amino acid transporter from Homo sapiens (Human) 8e-05 47.0 to K: in dbSNP:rs1060250 230 N 192 H 9751058 PfGW456L13_318 Histidine transport protein (permease) SwissProt LAT1_HUMAN 22.2 185 403 223 438 Large neutral amino acids transporter small subunit 1; 4F2 light chain; 4F2 LC; 4F2LC; CD98 light chain; Integral membrane protein E16; E16; L-type amino acid transporter 1; hLAT1; Solute carrier family 7 member 5; y+ system cationic amino acid transporter from Homo sapiens (Human) 8e-05 47.0 mutation to V: Nearly abolishes leucine transport activity. 246 A 206 S 30867591 PfGW456L13_318 Histidine transport protein (permease) SwissProt LAT1_HUMAN 22.2 185 403 223 438 Large neutral amino acids transporter small subunit 1; 4F2 light chain; 4F2 LC; 4F2LC; CD98 light chain; Integral membrane protein E16; E16; L-type amino acid transporter 1; hLAT1; Solute carrier family 7 member 5; y+ system cationic amino acid transporter from Homo sapiens (Human) 8e-05 47.0 mutation to A: Nearly abolishes leucine transport activity. 252 F 212 F 30867591 PfGW456L13_318 Histidine transport protein (permease) SwissProt LAT1_HUMAN 22.2 185 403 223 438 Large neutral amino acids transporter small subunit 1; 4F2 light chain; 4F2 LC; 4F2LC; CD98 light chain; Integral membrane protein E16; E16; L-type amino acid transporter 1; hLAT1; Solute carrier family 7 member 5; y+ system cationic amino acid transporter from Homo sapiens (Human) 8e-05 47.0 mutation to A: Nearly abolishes leucine transport activity. 257 W 217 I 30867591 PfGW456L13_318 Histidine transport protein (permease) SwissProt LAT1_HUMAN 22.2 185 403 223 438 Large neutral amino acids transporter small subunit 1; 4F2 light chain; 4F2 LC; 4F2LC; CD98 light chain; Integral membrane protein E16; E16; L-type amino acid transporter 1; hLAT1; Solute carrier family 7 member 5; y+ system cationic amino acid transporter from Homo sapiens (Human) 8e-05 47.0 mutation to A: Decreased leucine transport activity.; mutation to D: Nearly abolishes leucine transport activity. 258 N 218 E 30867591 PfGW456L13_318 Histidine transport protein (permease) SwissProt LAT1_HUMAN 22.2 185 403 223 438 Large neutral amino acids transporter small subunit 1; 4F2 light chain; 4F2 LC; 4F2LC; CD98 light chain; Integral membrane protein E16; E16; L-type amino acid transporter 1; hLAT1; Solute carrier family 7 member 5; y+ system cationic amino acid transporter from Homo sapiens (Human) 8e-05 47.0 mutation to A: Strongly decreased leucine transport activity. 259 Y 219 I 30867591 PfGW456L13_318 Histidine transport protein (permease) SwissProt LAT1_HUMAN 22.2 185 403 223 438 Large neutral amino acids transporter small subunit 1; 4F2 light chain; 4F2 LC; 4F2LC; CD98 light chain; Integral membrane protein E16; E16; L-type amino acid transporter 1; hLAT1; Solute carrier family 7 member 5; y+ system cationic amino acid transporter from Homo sapiens (Human) 8e-05 47.0 mutation to K: Decreased leucine transport activity. 303 E 263 Q 30867591 PfGW456L13_318 Histidine transport protein (permease) SwissProt LAT1_HUMAN 22.2 185 403 223 438 Large neutral amino acids transporter small subunit 1; 4F2 light chain; 4F2 LC; 4F2LC; CD98 light chain; Integral membrane protein E16; E16; L-type amino acid transporter 1; hLAT1; Solute carrier family 7 member 5; y+ system cationic amino acid transporter from Homo sapiens (Human) 8e-05 47.0 mutation to L: Nearly abolishes leucine transport activity. 375 P 340 M 30867591 PfGW456L13_318 Histidine transport protein (permease) SwissProt LAT1_HUMAN 22.2 185 403 223 438 Large neutral amino acids transporter small subunit 1; 4F2 light chain; 4F2 LC; 4F2LC; CD98 light chain; Integral membrane protein E16; E16; L-type amino acid transporter 1; hLAT1; Solute carrier family 7 member 5; y+ system cationic amino acid transporter from Homo sapiens (Human) 8e-05 47.0 Y→A: Strongly decreased leucine transport activity. 117 30867591 PfGW456L13_318 Histidine transport protein (permease) SwissProt LAT1_HUMAN 22.2 185 403 223 438 Large neutral amino acids transporter small subunit 1; 4F2 light chain; 4F2 LC; 4F2LC; CD98 light chain; Integral membrane protein E16; E16; L-type amino acid transporter 1; hLAT1; Solute carrier family 7 member 5; y+ system cationic amino acid transporter from Homo sapiens (Human) 8e-05 47.0 modified: Interchain (with C-210 in SLC3A2) 164 30867591 PfGW456L13_318 Histidine transport protein (permease) SwissProt LAT1_HUMAN 22.2 185 403 223 438 Large neutral amino acids transporter small subunit 1; 4F2 light chain; 4F2 LC; 4F2LC; CD98 light chain; Integral membrane protein E16; E16; L-type amino acid transporter 1; hLAT1; Solute carrier family 7 member 5; y+ system cationic amino acid transporter from Homo sapiens (Human) 8e-05 47.0 mutation Missing: Nearly abolishes leucine transport activity. 483..507 30867591