queryId subjectDb subjectId identity queryAlnBegin queryAlnEnd sujectAlnBegin subjectAlnEnd subjectDescription evalue bits subjectSite subjectSiteRange subjectSiteSeq querySiteRange querySiteSeq pubMedIds SMc03846 SMc03846 aconitate hydratase SwissProt ACNA_MYCS2 55.8 4 894 10 938 Aconitate hydratase A; ACN; Aconitase; (2R,3S)-2-methylisocitrate dehydratase; (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate dehydratase; Iron-responsive protein-like; IRP-like; Probable 2-methyl-cis-aconitate hydratase; RNA-binding protein; EC 4.2.1.3; EC 4.2.1.99 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) 0.0 1003 modified: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in... 394 K 399 A 20094657 SMc03846 SMc03846 aconitate hydratase SwissProt ACNA_BACSU 55.2 6 893 11 904 Aconitate hydratase A; ACN; Aconitase; Aconitate/2-methylaconitate hydratase; Iron-responsive protein-like; IRP-like; RNA-binding protein; EC 4.2.1.3; EC 4.2.1.- from Bacillus subtilis (strain 168) 0.0 992 mutation to S: Loss of aconitase activity. It is... 450 C 437 C 23354745 SMc03846 SMc03846 aconitate hydratase SwissProt ACNA_BACSU 55.2 6 893 11 904 Aconitate hydratase A; ACN; Aconitase; Aconitate/2-methylaconitate hydratase; Iron-responsive protein-like; IRP-like; RNA-binding protein; EC 4.2.1.3; EC 4.2.1.- from Bacillus subtilis (strain 168) 0.0 992 mutation to E: Same aconitase activity compared to the... 741 R 728 R 23354745 SMc03846 SMc03846 aconitate hydratase SwissProt ACNA_BACSU 55.2 6 893 11 904 Aconitate hydratase A; ACN; Aconitase; Aconitate/2-methylaconitate hydratase; Iron-responsive protein-like; IRP-like; RNA-binding protein; EC 4.2.1.3; EC 4.2.1.- from Bacillus subtilis (strain 168) 0.0 992 modified: Initiator methionine, Removed 1 3110133 SMc03846 SMc03846 aconitate hydratase SwissProt ACO3M_ARATH 54.2 23 895 117 988 Aconitate hydratase 3, mitochondrial; Aconitase 3; mACO1; Citrate hydro-lyase 3; EC 4.2.1.3 from Arabidopsis thaliana (Mouse-ear cress) 0.0 949 modified: Phosphoserine 91 25307043 SMc03846 SMc03846 aconitate hydratase SwissProt ACOHC_HUMAN 51.4 39 895 34 888 Cytoplasmic aconitate hydratase; Aconitase; Citrate hydro-lyase; Ferritin repressor protein; Iron regulatory protein 1; IRP1; Iron-responsive element-binding protein 1; IRE-BP 1; EC 4.2.1.3 from Homo sapiens (Human) 0.0 893 mutation to S: No effect on aconitase activity or... 300 C 310 G 8041788 SMc03846 SMc03846 aconitate hydratase SwissProt ACOHC_HUMAN 51.4 39 895 34 888 Cytoplasmic aconitate hydratase; Aconitase; Citrate hydro-lyase; Ferritin repressor protein; Iron regulatory protein 1; IRP1; Iron-responsive element-binding protein 1; IRE-BP 1; EC 4.2.1.3 from Homo sapiens (Human) 0.0 893 to M: in dbSNP:rs150373174 318 T 328 N 23033978 SMc03846 SMc03846 aconitate hydratase SwissProt ACOHC_HUMAN 51.4 39 895 34 888 Cytoplasmic aconitate hydratase; Aconitase; Citrate hydro-lyase; Ferritin repressor protein; Iron regulatory protein 1; IRP1; Iron-responsive element-binding protein 1; IRE-BP 1; EC 4.2.1.3 from Homo sapiens (Human) 0.0 893 mutation to S: Loss of aconitase activity. Leads to... 437 C 437 C 8041788 SMc03846 SMc03846 aconitate hydratase SwissProt ACOHC_HUMAN 51.4 39 895 34 888 Cytoplasmic aconitate hydratase; Aconitase; Citrate hydro-lyase; Ferritin repressor protein; Iron regulatory protein 1; IRP1; Iron-responsive element-binding protein 1; IRE-BP 1; EC 4.2.1.3 from Homo sapiens (Human) 0.0 893 mutation to S: Loss of aconitase activity. Leads to... 503 C 503 C 8041788 SMc03846 SMc03846 aconitate hydratase SwissProt ACOHC_HUMAN 51.4 39 895 34 888 Cytoplasmic aconitate hydratase; Aconitase; Citrate hydro-lyase; Ferritin repressor protein; Iron regulatory protein 1; IRP1; Iron-responsive element-binding protein 1; IRE-BP 1; EC 4.2.1.3 from Homo sapiens (Human) 0.0 893 mutation to S: Loss of aconitase activity. Leads to... 506 C 506 C 8041788 SMc03846 SMc03846 aconitate hydratase SwissProt ACOHC_HUMAN 51.4 39 895 34 888 Cytoplasmic aconitate hydratase; Aconitase; Citrate hydro-lyase; Ferritin repressor protein; Iron regulatory protein 1; IRP1; Iron-responsive element-binding protein 1; IRE-BP 1; EC 4.2.1.3 from Homo sapiens (Human) 0.0 893 mutation to Q: Strongly reduced RNA binding. 536 R 536 R 8041788 SMc03846 SMc03846 aconitate hydratase SwissProt ACOHC_HUMAN 51.4 39 895 34 888 Cytoplasmic aconitate hydratase; Aconitase; Citrate hydro-lyase; Ferritin repressor protein; Iron regulatory protein 1; IRP1; Iron-responsive element-binding protein 1; IRE-BP 1; EC 4.2.1.3 from Homo sapiens (Human) 0.0 893 mutation to Q: Strongly reduced RNA binding. 541 R 541 R 8041788 SMc03846 SMc03846 aconitate hydratase SwissProt ACOHC_HUMAN 51.4 39 895 34 888 Cytoplasmic aconitate hydratase; Aconitase; Citrate hydro-lyase; Ferritin repressor protein; Iron regulatory protein 1; IRP1; Iron-responsive element-binding protein 1; IRE-BP 1; EC 4.2.1.3 from Homo sapiens (Human) 0.0 893 mutation to K: No effect on RNA binding. 699 R 699 H 8041788 SMc03846 SMc03846 aconitate hydratase SwissProt ACOHC_HUMAN 51.4 39 895 34 888 Cytoplasmic aconitate hydratase; Aconitase; Citrate hydro-lyase; Ferritin repressor protein; Iron regulatory protein 1; IRP1; Iron-responsive element-binding protein 1; IRE-BP 1; EC 4.2.1.3 from Homo sapiens (Human) 0.0 893 mutation to A: No effect on iron-regulated RNA binding.... 778 S 781 S 8041788 SMc03846 SMc03846 aconitate hydratase SwissProt ACOHC_HUMAN 51.4 39 895 34 888 Cytoplasmic aconitate hydratase; Aconitase; Citrate hydro-lyase; Ferritin repressor protein; Iron regulatory protein 1; IRP1; Iron-responsive element-binding protein 1; IRE-BP 1; EC 4.2.1.3 from Homo sapiens (Human) 0.0 893 mutation to Q: Nearly abolishes RNA binding. 780 R 783 R 8041788 SMc03846 SMc03846 aconitate hydratase PDB 2b3x:A 51.4 39 895 33 887 Structure of an orthorhombic crystal form of human cytosolic aconitase (irp1) 0.0 893 active site 124 D 131 D 16407072 SMc03846 SMc03846 aconitate hydratase PDB 2b3x:A 51.4 39 895 33 887 Structure of an orthorhombic crystal form of human cytosolic aconitase (irp1) 0.0 893 active site 125 H 132 H 16407072 SMc03846 SMc03846 aconitate hydratase PDB 2b3x:A 51.4 39 895 33 887 Structure of an orthorhombic crystal form of human cytosolic aconitase (irp1) 0.0 893 active site 204 D 215 D 16407072 SMc03846 SMc03846 aconitate hydratase PDB 2b3x:A 51.4 39 895 33 887 Structure of an orthorhombic crystal form of human cytosolic aconitase (irp1) 0.0 893 active site 535 R 536 R 16407072 SMc03846 SMc03846 aconitate hydratase PDB 2b3x:A 51.4 39 895 33 887 Structure of an orthorhombic crystal form of human cytosolic aconitase (irp1) 0.0 893 active site 777 S 781 S 16407072 SMc03846 SMc03846 aconitate hydratase PDB 2b3x:A 51.4 39 895 33 887 Structure of an orthorhombic crystal form of human cytosolic aconitase (irp1) 0.0 893 active site 779 R 783 R 16407072 SMc03846 SMc03846 aconitate hydratase PDB 2b3x:A 51.4 39 895 33 887 Structure of an orthorhombic crystal form of human cytosolic aconitase (irp1) 0.0 893 binding iron/sulfur cluster 175 I 182 I 16407072 SMc03846 SMc03846 aconitate hydratase PDB 2b3x:A 51.4 39 895 33 887 Structure of an orthorhombic crystal form of human cytosolic aconitase (irp1) 0.0 893 binding iron/sulfur cluster 206 H 217 H 16407072 SMc03846 SMc03846 aconitate hydratase PDB 2b3x:A 51.4 39 895 33 887 Structure of an orthorhombic crystal form of human cytosolic aconitase (irp1) 0.0 893 binding iron/sulfur cluster 436 C 437 C 16407072 SMc03846 SMc03846 aconitate hydratase PDB 2b3x:A 51.4 39 895 33 887 Structure of an orthorhombic crystal form of human cytosolic aconitase (irp1) 0.0 893 binding iron/sulfur cluster 502 C 503 C 16407072 SMc03846 SMc03846 aconitate hydratase PDB 2b3x:A 51.4 39 895 33 887 Structure of an orthorhombic crystal form of human cytosolic aconitase (irp1) 0.0 893 binding iron/sulfur cluster 505 C 506 C 16407072 SMc03846 SMc03846 aconitate hydratase PDB 2b3x:A 51.4 39 895 33 887 Structure of an orthorhombic crystal form of human cytosolic aconitase (irp1) 0.0 893 binding iron/sulfur cluster 506 I 507 I 16407072 SMc03846 SMc03846 aconitate hydratase PDB 2b3x:A 51.4 39 895 33 887 Structure of an orthorhombic crystal form of human cytosolic aconitase (irp1) 0.0 893 binding iron/sulfur cluster 534 N 535 N 16407072 SMc03846 SMc03846 aconitate hydratase PDB 3snp:A 50.1 39 895 33 849 Crystal structure analysis of iron regulatory protein 1 in complex with ferritin h ire RNA 0.0 807 active site 124 D 131 D 17185597 SMc03846 SMc03846 aconitate hydratase PDB 3snp:A 50.1 39 895 33 849 Crystal structure analysis of iron regulatory protein 1 in complex with ferritin h ire RNA 0.0 807 active site 125 H 132 H 17185597 SMc03846 SMc03846 aconitate hydratase PDB 3snp:A 50.1 39 895 33 849 Crystal structure analysis of iron regulatory protein 1 in complex with ferritin h ire RNA 0.0 807 active site 186 D 215 D 17185597 SMc03846 SMc03846 aconitate hydratase PDB 3snp:A 50.1 39 895 33 849 Crystal structure analysis of iron regulatory protein 1 in complex with ferritin h ire RNA 0.0 807 active site 505 R 536 R 17185597 SMc03846 SMc03846 aconitate hydratase PDB 3snp:A 50.1 39 895 33 849 Crystal structure analysis of iron regulatory protein 1 in complex with ferritin h ire RNA 0.0 807 active site 739 S 781 S 17185597 SMc03846 SMc03846 aconitate hydratase PDB 3snp:A 50.1 39 895 33 849 Crystal structure analysis of iron regulatory protein 1 in complex with ferritin h ire RNA 0.0 807 active site 741 R 783 R 17185597 SMc03846 SMc03846 aconitate hydratase PDB 3snp:A 50.1 39 895 33 849 Crystal structure analysis of iron regulatory protein 1 in complex with ferritin h ire RNA 0.0 807 binding rna 125 H 132 H 17185597 SMc03846 SMc03846 aconitate hydratase PDB 3snp:A 50.1 39 895 33 849 Crystal structure analysis of iron regulatory protein 1 in complex with ferritin h ire RNA 0.0 807 binding rna 126 S 133 S 17185597 SMc03846 SMc03846 aconitate hydratase PDB 3snp:A 50.1 39 895 33 849 Crystal structure analysis of iron regulatory protein 1 in complex with ferritin h ire RNA 0.0 807 binding rna 188 H 217 H 17185597 SMc03846 SMc03846 aconitate hydratase PDB 3snp:A 50.1 39 895 33 849 Crystal structure analysis of iron regulatory protein 1 in complex with ferritin h ire RNA 0.0 807 binding rna 243 L 272 L 17185597 SMc03846 SMc03846 aconitate hydratase PDB 3snp:A 50.1 39 895 33 849 Crystal structure analysis of iron regulatory protein 1 in complex with ferritin h ire RNA 0.0 807 binding rna 250 R 279 R 17185597 SMc03846 SMc03846 aconitate hydratase PDB 3snp:A 50.1 39 895 33 849 Crystal structure analysis of iron regulatory protein 1 in complex with ferritin h ire RNA 0.0 807 binding rna 279 N 308 N 17185597 SMc03846 SMc03846 aconitate hydratase PDB 3snp:A 50.1 39 895 33 849 Crystal structure analysis of iron regulatory protein 1 in complex with ferritin h ire RNA 0.0 807 binding rna 283 E 312 E 17185597 SMc03846 SMc03846 aconitate hydratase PDB 3snp:A 50.1 39 895 33 849 Crystal structure analysis of iron regulatory protein 1 in complex with ferritin h ire RNA 0.0 807 binding rna 352 S 379 A 17185597 SMc03846 SMc03846 aconitate hydratase PDB 3snp:A 50.1 39 895 33 849 Crystal structure analysis of iron regulatory protein 1 in complex with ferritin h ire RNA 0.0 807 binding rna 357 P 384 P 17185597 SMc03846 SMc03846 aconitate hydratase PDB 3snp:A 50.1 39 895 33 849 Crystal structure analysis of iron regulatory protein 1 in complex with ferritin h ire RNA 0.0 807 binding rna 360 K 387 R 17185597 SMc03846 SMc03846 aconitate hydratase PDB 3snp:A 50.1 39 895 33 849 Crystal structure analysis of iron regulatory protein 1 in complex with ferritin h ire RNA 0.0 807 binding rna 419 T 438 T 17185597 SMc03846 SMc03846 aconitate hydratase PDB 3snp:A 50.1 39 895 33 849 Crystal structure analysis of iron regulatory protein 1 in complex with ferritin h ire RNA 0.0 807 binding rna 420 N 439 N 17185597 SMc03846 SMc03846 aconitate hydratase PDB 3snp:A 50.1 39 895 33 849 Crystal structure analysis of iron regulatory protein 1 in complex with ferritin h ire RNA 0.0 807 binding rna 421 T 440 T 17185597 SMc03846 SMc03846 aconitate hydratase PDB 3snp:A 50.1 39 895 33 849 Crystal structure analysis of iron regulatory protein 1 in complex with ferritin h ire RNA 0.0 807 binding rna 504 N 535 N 17185597 SMc03846 SMc03846 aconitate hydratase PDB 3snp:A 50.1 39 895 33 849 Crystal structure analysis of iron regulatory protein 1 in complex with ferritin h ire RNA 0.0 807 binding rna 505 R 536 R 17185597 SMc03846 SMc03846 aconitate hydratase PDB 3snp:A 50.1 39 895 33 849 Crystal structure analysis of iron regulatory protein 1 in complex with ferritin h ire RNA 0.0 807 binding rna 520 L 551 L 17185597 SMc03846 SMc03846 aconitate hydratase PDB 3snp:A 50.1 39 895 33 849 Crystal structure analysis of iron regulatory protein 1 in complex with ferritin h ire RNA 0.0 807 binding rna 642 S 681 S 17185597 SMc03846 SMc03846 aconitate hydratase PDB 3snp:A 50.1 39 895 33 849 Crystal structure analysis of iron regulatory protein 1 in complex with ferritin h ire RNA 0.0 807 binding rna 643 P 682 P 17185597 SMc03846 SMc03846 aconitate hydratase PDB 3snp:A 50.1 39 895 33 849 Crystal structure analysis of iron regulatory protein 1 in complex with ferritin h ire RNA 0.0 807 binding rna 644 A 683 A 17185597 SMc03846 SMc03846 aconitate hydratase PDB 3snp:A 50.1 39 895 33 849 Crystal structure analysis of iron regulatory protein 1 in complex with ferritin h ire RNA 0.0 807 binding rna 645 G 684 G 17185597 SMc03846 SMc03846 aconitate hydratase PDB 3snp:A 50.1 39 895 33 849 Crystal structure analysis of iron regulatory protein 1 in complex with ferritin h ire RNA 0.0 807 binding rna 646 N 685 S 17185597 SMc03846 SMc03846 aconitate hydratase PDB 3snp:A 50.1 39 895 33 849 Crystal structure analysis of iron regulatory protein 1 in complex with ferritin h ire RNA 0.0 807 binding rna 649 R 688 A 17185597 SMc03846 SMc03846 aconitate hydratase PDB 3snp:A 50.1 39 895 33 849 Crystal structure analysis of iron regulatory protein 1 in complex with ferritin h ire RNA 0.0 807 binding rna 665 R 704 A 17185597 SMc03846 SMc03846 aconitate hydratase PDB 3snp:A 50.1 39 895 33 849 Crystal structure analysis of iron regulatory protein 1 in complex with ferritin h ire RNA 0.0 807 binding rna 669 S 708 Q 17185597 SMc03846 SMc03846 aconitate hydratase PDB 3snp:A 50.1 39 895 33 849 Crystal structure analysis of iron regulatory protein 1 in complex with ferritin h ire RNA 0.0 807 binding rna 671 G 710 G 17185597 SMc03846 SMc03846 aconitate hydratase PDB 3snp:A 50.1 39 895 33 849 Crystal structure analysis of iron regulatory protein 1 in complex with ferritin h ire RNA 0.0 807 binding rna 674 R 713 R 17185597 SMc03846 SMc03846 aconitate hydratase PDB 3snp:A 50.1 39 895 33 849 Crystal structure analysis of iron regulatory protein 1 in complex with ferritin h ire RNA 0.0 807 binding rna 741 R 783 R 17185597 SMc03846 SMc03846 aconitate hydratase SwissProt ACON_YEAST 27.1 82 848 85 731 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 5e-50 198 mutation to K: Strongly diminishes the catalytic activity towards... 604 R 721 R 23106124 SMc03846 SMc03846 aconitate hydratase SwissProt ACON_YEAST 27.1 82 848 85 731 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 5e-50 198 modified: transit peptide, Mitochondrion 1..16 15975908 SMc03846 SMc03846 aconitate hydratase SwissProt ACON2_YEAST 26.3 40 840 54 729 Homocitrate dehydratase, mitochondrial; Aconitase 2; EC 4.2.1.- from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 9e-46 184 mutation to R: Reduces catalytic activity towards homoaconitate by... 610 K 721 R 23106124 SMc03846 SMc03846 aconitate hydratase PDB 8acn:A 27.3 85 868 64 726 Crystal structures of aconitase with isocitrate and nitroisocitrate bound 2e-43 176 active site 99 D 131 D 1547214 SMc03846 SMc03846 aconitate hydratase PDB 8acn:A 27.3 85 868 64 726 Crystal structures of aconitase with isocitrate and nitroisocitrate bound 2e-43 176 active site 100 H 132 H 1547214 SMc03846 SMc03846 aconitate hydratase PDB 8acn:A 27.3 85 868 64 726 Crystal structures of aconitase with isocitrate and nitroisocitrate bound 2e-43 176 active site 164 D 215 D 1547214 SMc03846 SMc03846 aconitate hydratase PDB 8acn:A 27.3 85 868 64 726 Crystal structures of aconitase with isocitrate and nitroisocitrate bound 2e-43 176 active site 446 R 536 R 1547214 SMc03846 SMc03846 aconitate hydratase PDB 8acn:A 27.3 85 868 64 726 Crystal structures of aconitase with isocitrate and nitroisocitrate bound 2e-43 176 active site 641 S 781 S 1547214 SMc03846 SMc03846 aconitate hydratase PDB 8acn:A 27.3 85 868 64 726 Crystal structures of aconitase with isocitrate and nitroisocitrate bound 2e-43 176 active site 643 R 783 R 1547214 SMc03846 SMc03846 aconitate hydratase PDB 8acn:A 27.3 85 868 64 726 Crystal structures of aconitase with isocitrate and nitroisocitrate bound 2e-43 176 binding nitroisocitric acid 71 Q 92 Q 1547214 SMc03846 SMc03846 aconitate hydratase PDB 8acn:A 27.3 85 868 64 726 Crystal structures of aconitase with isocitrate and nitroisocitrate bound 2e-43 176 binding nitroisocitric acid 74 T 95 T 1547214 SMc03846 SMc03846 aconitate hydratase PDB 8acn:A 27.3 85 868 64 726 Crystal structures of aconitase with isocitrate and nitroisocitrate bound 2e-43 176 binding nitroisocitric acid 100 H 132 H 1547214 SMc03846 SMc03846 aconitate hydratase PDB 8acn:A 27.3 85 868 64 726 Crystal structures of aconitase with isocitrate and nitroisocitrate bound 2e-43 176 binding nitroisocitric acid 164 D 215 D 1547214 SMc03846 SMc03846 aconitate hydratase PDB 8acn:A 27.3 85 868 64 726 Crystal structures of aconitase with isocitrate and nitroisocitrate bound 2e-43 176 binding nitroisocitric acid 165 S 216 S 1547214 SMc03846 SMc03846 aconitate hydratase PDB 8acn:A 27.3 85 868 64 726 Crystal structures of aconitase with isocitrate and nitroisocitrate bound 2e-43 176 binding nitroisocitric acid 446 R 536 R 1547214 SMc03846 SMc03846 aconitate hydratase PDB 8acn:A 27.3 85 868 64 726 Crystal structures of aconitase with isocitrate and nitroisocitrate bound 2e-43 176 binding nitroisocitric acid 451 R 541 R 1547214 SMc03846 SMc03846 aconitate hydratase PDB 8acn:A 27.3 85 868 64 726 Crystal structures of aconitase with isocitrate and nitroisocitrate bound 2e-43 176 binding nitroisocitric acid 579 R 721 R 1547214 SMc03846 SMc03846 aconitate hydratase PDB 8acn:A 27.3 85 868 64 726 Crystal structures of aconitase with isocitrate and nitroisocitrate bound 2e-43 176 binding nitroisocitric acid 641 S 781 S 1547214 SMc03846 SMc03846 aconitate hydratase PDB 8acn:A 27.3 85 868 64 726 Crystal structures of aconitase with isocitrate and nitroisocitrate bound 2e-43 176 binding nitroisocitric acid 642 S 782 S 1547214 SMc03846 SMc03846 aconitate hydratase PDB 8acn:A 27.3 85 868 64 726 Crystal structures of aconitase with isocitrate and nitroisocitrate bound 2e-43 176 binding nitroisocitric acid 643 R 783 R 1547214 SMc03846 SMc03846 aconitate hydratase PDB 8acn:A 27.3 85 868 64 726 Crystal structures of aconitase with isocitrate and nitroisocitrate bound 2e-43 176 binding iron/sulfur cluster 100 H 132 H 1547214 SMc03846 SMc03846 aconitate hydratase PDB 8acn:A 27.3 85 868 64 726 Crystal structures of aconitase with isocitrate and nitroisocitrate bound 2e-43 176 binding iron/sulfur cluster 164 D 215 D 1547214 SMc03846 SMc03846 aconitate hydratase PDB 8acn:A 27.3 85 868 64 726 Crystal structures of aconitase with isocitrate and nitroisocitrate bound 2e-43 176 binding iron/sulfur cluster 166 H 217 H 1547214 SMc03846 SMc03846 aconitate hydratase PDB 8acn:A 27.3 85 868 64 726 Crystal structures of aconitase with isocitrate and nitroisocitrate bound 2e-43 176 binding iron/sulfur cluster 356 S 436 S 1547214 SMc03846 SMc03846 aconitate hydratase PDB 8acn:A 27.3 85 868 64 726 Crystal structures of aconitase with isocitrate and nitroisocitrate bound 2e-43 176 binding iron/sulfur cluster 357 C 437 C 1547214 SMc03846 SMc03846 aconitate hydratase PDB 8acn:A 27.3 85 868 64 726 Crystal structures of aconitase with isocitrate and nitroisocitrate bound 2e-43 176 binding iron/sulfur cluster 420 C 503 C 1547214 SMc03846 SMc03846 aconitate hydratase PDB 8acn:A 27.3 85 868 64 726 Crystal structures of aconitase with isocitrate and nitroisocitrate bound 2e-43 176 binding iron/sulfur cluster 423 C 506 C 1547214 SMc03846 SMc03846 aconitate hydratase PDB 8acn:A 27.3 85 868 64 726 Crystal structures of aconitase with isocitrate and nitroisocitrate bound 2e-43 176 binding iron/sulfur cluster 424 I 507 I 1547214 SMc03846 SMc03846 aconitate hydratase PDB 1fgh:A 27.3 85 868 64 726 Complex with 4-hydroxy-trans-aconitate 2e-43 176 active site 99 D 131 D 8942997 SMc03846 SMc03846 aconitate hydratase PDB 1fgh:A 27.3 85 868 64 726 Complex with 4-hydroxy-trans-aconitate 2e-43 176 active site 100 H 132 H 8942997 SMc03846 SMc03846 aconitate hydratase PDB 1fgh:A 27.3 85 868 64 726 Complex with 4-hydroxy-trans-aconitate 2e-43 176 active site 164 D 215 D 8942997 SMc03846 SMc03846 aconitate hydratase PDB 1fgh:A 27.3 85 868 64 726 Complex with 4-hydroxy-trans-aconitate 2e-43 176 active site 446 R 536 R 8942997 SMc03846 SMc03846 aconitate hydratase PDB 1fgh:A 27.3 85 868 64 726 Complex with 4-hydroxy-trans-aconitate 2e-43 176 active site 641 S 781 S 8942997 SMc03846 SMc03846 aconitate hydratase PDB 1fgh:A 27.3 85 868 64 726 Complex with 4-hydroxy-trans-aconitate 2e-43 176 active site 643 R 783 R 8942997 SMc03846 SMc03846 aconitate hydratase PDB 1fgh:A 27.3 85 868 64 726 Complex with 4-hydroxy-trans-aconitate 2e-43 176 binding 4-hydroxy-aconitate ion 71 Q 92 Q 8942997 SMc03846 SMc03846 aconitate hydratase PDB 1fgh:A 27.3 85 868 64 726 Complex with 4-hydroxy-trans-aconitate 2e-43 176 binding 4-hydroxy-aconitate ion 74 T 95 T 8942997 SMc03846 SMc03846 aconitate hydratase PDB 1fgh:A 27.3 85 868 64 726 Complex with 4-hydroxy-trans-aconitate 2e-43 176 binding 4-hydroxy-aconitate ion 100 H 132 H 8942997 SMc03846 SMc03846 aconitate hydratase PDB 1fgh:A 27.3 85 868 64 726 Complex with 4-hydroxy-trans-aconitate 2e-43 176 binding 4-hydroxy-aconitate ion 164 D 215 D 8942997 SMc03846 SMc03846 aconitate hydratase PDB 1fgh:A 27.3 85 868 64 726 Complex with 4-hydroxy-trans-aconitate 2e-43 176 binding 4-hydroxy-aconitate ion 165 S 216 S 8942997 SMc03846 SMc03846 aconitate hydratase PDB 1fgh:A 27.3 85 868 64 726 Complex with 4-hydroxy-trans-aconitate 2e-43 176 binding 4-hydroxy-aconitate ion 446 R 536 R 8942997 SMc03846 SMc03846 aconitate hydratase PDB 1fgh:A 27.3 85 868 64 726 Complex with 4-hydroxy-trans-aconitate 2e-43 176 binding 4-hydroxy-aconitate ion 451 R 541 R 8942997 SMc03846 SMc03846 aconitate hydratase PDB 1fgh:A 27.3 85 868 64 726 Complex with 4-hydroxy-trans-aconitate 2e-43 176 binding 4-hydroxy-aconitate ion 579 R 721 R 8942997 SMc03846 SMc03846 aconitate hydratase PDB 1fgh:A 27.3 85 868 64 726 Complex with 4-hydroxy-trans-aconitate 2e-43 176 binding 4-hydroxy-aconitate ion 641 S 781 S 8942997 SMc03846 SMc03846 aconitate hydratase PDB 1fgh:A 27.3 85 868 64 726 Complex with 4-hydroxy-trans-aconitate 2e-43 176 binding 4-hydroxy-aconitate ion 642 S 782 S 8942997 SMc03846 SMc03846 aconitate hydratase PDB 1fgh:A 27.3 85 868 64 726 Complex with 4-hydroxy-trans-aconitate 2e-43 176 binding 4-hydroxy-aconitate ion 643 R 783 R 8942997 SMc03846 SMc03846 aconitate hydratase PDB 1fgh:A 27.3 85 868 64 726 Complex with 4-hydroxy-trans-aconitate 2e-43 176 binding iron/sulfur cluster 100 H 132 H 8942997 SMc03846 SMc03846 aconitate hydratase PDB 1fgh:A 27.3 85 868 64 726 Complex with 4-hydroxy-trans-aconitate 2e-43 176 binding iron/sulfur cluster 164 D 215 D 8942997 SMc03846 SMc03846 aconitate hydratase PDB 1fgh:A 27.3 85 868 64 726 Complex with 4-hydroxy-trans-aconitate 2e-43 176 binding iron/sulfur cluster 166 H 217 H 8942997 SMc03846 SMc03846 aconitate hydratase PDB 1fgh:A 27.3 85 868 64 726 Complex with 4-hydroxy-trans-aconitate 2e-43 176 binding iron/sulfur cluster 356 S 436 S 8942997 SMc03846 SMc03846 aconitate hydratase PDB 1fgh:A 27.3 85 868 64 726 Complex with 4-hydroxy-trans-aconitate 2e-43 176 binding iron/sulfur cluster 357 C 437 C 8942997 SMc03846 SMc03846 aconitate hydratase PDB 1fgh:A 27.3 85 868 64 726 Complex with 4-hydroxy-trans-aconitate 2e-43 176 binding iron/sulfur cluster 420 C 503 C 8942997 SMc03846 SMc03846 aconitate hydratase PDB 1fgh:A 27.3 85 868 64 726 Complex with 4-hydroxy-trans-aconitate 2e-43 176 binding iron/sulfur cluster 423 C 506 C 8942997 SMc03846 SMc03846 aconitate hydratase PDB 1fgh:A 27.3 85 868 64 726 Complex with 4-hydroxy-trans-aconitate 2e-43 176 binding iron/sulfur cluster 424 I 507 I 8942997 SMc03846 SMc03846 aconitate hydratase PDB 1fgh:A 27.3 85 868 64 726 Complex with 4-hydroxy-trans-aconitate 2e-43 176 binding iron/sulfur cluster 451 R 541 R 8942997 SMc03846 SMc03846 aconitate hydratase PDB 1amj:A 27.3 85 868 64 726 Steric and conformational features of the aconitase mechanism 2e-43 176 active site 99 D 131 D 7675781 SMc03846 SMc03846 aconitate hydratase PDB 1amj:A 27.3 85 868 64 726 Steric and conformational features of the aconitase mechanism 2e-43 176 active site 100 H 132 H 7675781 SMc03846 SMc03846 aconitate hydratase PDB 1amj:A 27.3 85 868 64 726 Steric and conformational features of the aconitase mechanism 2e-43 176 active site 164 D 215 D 7675781 SMc03846 SMc03846 aconitate hydratase PDB 1amj:A 27.3 85 868 64 726 Steric and conformational features of the aconitase mechanism 2e-43 176 active site 446 R 536 R 7675781 SMc03846 SMc03846 aconitate hydratase PDB 1amj:A 27.3 85 868 64 726 Steric and conformational features of the aconitase mechanism 2e-43 176 active site 641 S 781 S 7675781 SMc03846 SMc03846 aconitate hydratase PDB 1amj:A 27.3 85 868 64 726 Steric and conformational features of the aconitase mechanism 2e-43 176 active site 643 R 783 R 7675781 SMc03846 SMc03846 aconitate hydratase PDB 1amj:A 27.3 85 868 64 726 Steric and conformational features of the aconitase mechanism 2e-43 176 binding iron/sulfur cluster 144 I 182 I 7675781 SMc03846 SMc03846 aconitate hydratase PDB 1amj:A 27.3 85 868 64 726 Steric and conformational features of the aconitase mechanism 2e-43 176 binding iron/sulfur cluster 166 H 217 H 7675781 SMc03846 SMc03846 aconitate hydratase PDB 1amj:A 27.3 85 868 64 726 Steric and conformational features of the aconitase mechanism 2e-43 176 binding iron/sulfur cluster 357 C 437 C 7675781 SMc03846 SMc03846 aconitate hydratase PDB 1amj:A 27.3 85 868 64 726 Steric and conformational features of the aconitase mechanism 2e-43 176 binding iron/sulfur cluster 420 C 503 C 7675781 SMc03846 SMc03846 aconitate hydratase PDB 1amj:A 27.3 85 868 64 726 Steric and conformational features of the aconitase mechanism 2e-43 176 binding iron/sulfur cluster 423 C 506 C 7675781 SMc03846 SMc03846 aconitate hydratase PDB 1amj:A 27.3 85 868 64 726 Steric and conformational features of the aconitase mechanism 2e-43 176 binding sulfate ion 71 Q 92 Q 7675781 SMc03846 SMc03846 aconitate hydratase PDB 1amj:A 27.3 85 868 64 726 Steric and conformational features of the aconitase mechanism 2e-43 176 binding sulfate ion 579 R 721 R 7675781 SMc03846 SMc03846 aconitate hydratase PDB 1amj:A 27.3 85 868 64 726 Steric and conformational features of the aconitase mechanism 2e-43 176 binding sulfate ion 643 R 783 R 7675781 SMc03846 SMc03846 aconitate hydratase PDB 1ami:A 27.3 85 868 64 726 Steric and conformational features of the aconitase mechanism 2e-43 176 active site 99 D 131 D 7675781 SMc03846 SMc03846 aconitate hydratase PDB 1ami:A 27.3 85 868 64 726 Steric and conformational features of the aconitase mechanism 2e-43 176 active site 100 H 132 H 7675781 SMc03846 SMc03846 aconitate hydratase PDB 1ami:A 27.3 85 868 64 726 Steric and conformational features of the aconitase mechanism 2e-43 176 active site 164 D 215 D 7675781 SMc03846 SMc03846 aconitate hydratase PDB 1ami:A 27.3 85 868 64 726 Steric and conformational features of the aconitase mechanism 2e-43 176 active site 446 R 536 R 7675781 SMc03846 SMc03846 aconitate hydratase PDB 1ami:A 27.3 85 868 64 726 Steric and conformational features of the aconitase mechanism 2e-43 176 active site 641 S 781 S 7675781 SMc03846 SMc03846 aconitate hydratase PDB 1ami:A 27.3 85 868 64 726 Steric and conformational features of the aconitase mechanism 2e-43 176 active site 643 R 783 R 7675781 SMc03846 SMc03846 aconitate hydratase PDB 1ami:A 27.3 85 868 64 726 Steric and conformational features of the aconitase mechanism 2e-43 176 binding alpha-methylisocitric acid 71 Q 92 Q 7675781 SMc03846 SMc03846 aconitate hydratase PDB 1ami:A 27.3 85 868 64 726 Steric and conformational features of the aconitase mechanism 2e-43 176 binding alpha-methylisocitric acid 74 T 95 T 7675781 SMc03846 SMc03846 aconitate hydratase PDB 1ami:A 27.3 85 868 64 726 Steric and conformational features of the aconitase mechanism 2e-43 176 binding alpha-methylisocitric acid 100 H 132 H 7675781 SMc03846 SMc03846 aconitate hydratase PDB 1ami:A 27.3 85 868 64 726 Steric and conformational features of the aconitase mechanism 2e-43 176 binding alpha-methylisocitric acid 164 D 215 D 7675781 SMc03846 SMc03846 aconitate hydratase PDB 1ami:A 27.3 85 868 64 726 Steric and conformational features of the aconitase mechanism 2e-43 176 binding alpha-methylisocitric acid 165 S 216 S 7675781 SMc03846 SMc03846 aconitate hydratase PDB 1ami:A 27.3 85 868 64 726 Steric and conformational features of the aconitase mechanism 2e-43 176 binding alpha-methylisocitric acid 446 R 536 R 7675781 SMc03846 SMc03846 aconitate hydratase PDB 1ami:A 27.3 85 868 64 726 Steric and conformational features of the aconitase mechanism 2e-43 176 binding alpha-methylisocitric acid 451 R 541 R 7675781 SMc03846 SMc03846 aconitate hydratase PDB 1ami:A 27.3 85 868 64 726 Steric and conformational features of the aconitase mechanism 2e-43 176 binding alpha-methylisocitric acid 579 R 721 R 7675781 SMc03846 SMc03846 aconitate hydratase PDB 1ami:A 27.3 85 868 64 726 Steric and conformational features of the aconitase mechanism 2e-43 176 binding alpha-methylisocitric acid 641 S 781 S 7675781 SMc03846 SMc03846 aconitate hydratase PDB 1ami:A 27.3 85 868 64 726 Steric and conformational features of the aconitase mechanism 2e-43 176 binding alpha-methylisocitric acid 642 S 782 S 7675781 SMc03846 SMc03846 aconitate hydratase PDB 1ami:A 27.3 85 868 64 726 Steric and conformational features of the aconitase mechanism 2e-43 176 binding alpha-methylisocitric acid 643 R 783 R 7675781 SMc03846 SMc03846 aconitate hydratase PDB 1ami:A 27.3 85 868 64 726 Steric and conformational features of the aconitase mechanism 2e-43 176 binding iron/sulfur cluster 100 H 132 H 7675781 SMc03846 SMc03846 aconitate hydratase PDB 1ami:A 27.3 85 868 64 726 Steric and conformational features of the aconitase mechanism 2e-43 176 binding iron/sulfur cluster 144 I 182 I 7675781 SMc03846 SMc03846 aconitate hydratase PDB 1ami:A 27.3 85 868 64 726 Steric and conformational features of the aconitase mechanism 2e-43 176 binding iron/sulfur cluster 164 D 215 D 7675781 SMc03846 SMc03846 aconitate hydratase PDB 1ami:A 27.3 85 868 64 726 Steric and conformational features of the aconitase mechanism 2e-43 176 binding iron/sulfur cluster 166 H 217 H 7675781 SMc03846 SMc03846 aconitate hydratase PDB 1ami:A 27.3 85 868 64 726 Steric and conformational features of the aconitase mechanism 2e-43 176 binding iron/sulfur cluster 356 S 436 S 7675781 SMc03846 SMc03846 aconitate hydratase PDB 1ami:A 27.3 85 868 64 726 Steric and conformational features of the aconitase mechanism 2e-43 176 binding iron/sulfur cluster 357 C 437 C 7675781 SMc03846 SMc03846 aconitate hydratase PDB 1ami:A 27.3 85 868 64 726 Steric and conformational features of the aconitase mechanism 2e-43 176 binding iron/sulfur cluster 420 C 503 C 7675781 SMc03846 SMc03846 aconitate hydratase PDB 1ami:A 27.3 85 868 64 726 Steric and conformational features of the aconitase mechanism 2e-43 176 binding iron/sulfur cluster 423 C 506 C 7675781 SMc03846 SMc03846 aconitate hydratase PDB 1ami:A 27.3 85 868 64 726 Steric and conformational features of the aconitase mechanism 2e-43 176 binding iron/sulfur cluster 445 N 535 N 7675781 SMc03846 SMc03846 aconitate hydratase PDB 1aco:A 27.3 85 868 64 726 Crystal structure of aconitase with transaconitate bound 2e-43 176 active site 99 D 131 D 8151704 SMc03846 SMc03846 aconitate hydratase PDB 1aco:A 27.3 85 868 64 726 Crystal structure of aconitase with transaconitate bound 2e-43 176 active site 100 H 132 H 8151704 SMc03846 SMc03846 aconitate hydratase PDB 1aco:A 27.3 85 868 64 726 Crystal structure of aconitase with transaconitate bound 2e-43 176 active site 164 D 215 D 8151704 SMc03846 SMc03846 aconitate hydratase PDB 1aco:A 27.3 85 868 64 726 Crystal structure of aconitase with transaconitate bound 2e-43 176 active site 446 R 536 R 8151704 SMc03846 SMc03846 aconitate hydratase PDB 1aco:A 27.3 85 868 64 726 Crystal structure of aconitase with transaconitate bound 2e-43 176 active site 641 S 781 S 8151704 SMc03846 SMc03846 aconitate hydratase PDB 1aco:A 27.3 85 868 64 726 Crystal structure of aconitase with transaconitate bound 2e-43 176 active site 643 R 783 R 8151704 SMc03846 SMc03846 aconitate hydratase PDB 1aco:A 27.3 85 868 64 726 Crystal structure of aconitase with transaconitate bound 2e-43 176 binding iron/sulfur cluster 100 H 132 H 8151704 SMc03846 SMc03846 aconitate hydratase PDB 1aco:A 27.3 85 868 64 726 Crystal structure of aconitase with transaconitate bound 2e-43 176 binding iron/sulfur cluster 144 I 182 I 8151704 SMc03846 SMc03846 aconitate hydratase PDB 1aco:A 27.3 85 868 64 726 Crystal structure of aconitase with transaconitate bound 2e-43 176 binding iron/sulfur cluster 164 D 215 D 8151704 SMc03846 SMc03846 aconitate hydratase PDB 1aco:A 27.3 85 868 64 726 Crystal structure of aconitase with transaconitate bound 2e-43 176 binding iron/sulfur cluster 166 H 217 H 8151704 SMc03846 SMc03846 aconitate hydratase PDB 1aco:A 27.3 85 868 64 726 Crystal structure of aconitase with transaconitate bound 2e-43 176 binding iron/sulfur cluster 356 S 436 S 8151704 SMc03846 SMc03846 aconitate hydratase PDB 1aco:A 27.3 85 868 64 726 Crystal structure of aconitase with transaconitate bound 2e-43 176 binding iron/sulfur cluster 357 C 437 C 8151704 SMc03846 SMc03846 aconitate hydratase PDB 1aco:A 27.3 85 868 64 726 Crystal structure of aconitase with transaconitate bound 2e-43 176 binding iron/sulfur cluster 420 C 503 C 8151704 SMc03846 SMc03846 aconitate hydratase PDB 1aco:A 27.3 85 868 64 726 Crystal structure of aconitase with transaconitate bound 2e-43 176 binding iron/sulfur cluster 423 C 506 C 8151704 SMc03846 SMc03846 aconitate hydratase PDB 1aco:A 27.3 85 868 64 726 Crystal structure of aconitase with transaconitate bound 2e-43 176 binding iron/sulfur cluster 445 N 535 N 8151704 SMc03846 SMc03846 aconitate hydratase PDB 1aco:A 27.3 85 868 64 726 Crystal structure of aconitase with transaconitate bound 2e-43 176 binding aconitate ion 71 Q 92 Q 8151704 SMc03846 SMc03846 aconitate hydratase PDB 1aco:A 27.3 85 868 64 726 Crystal structure of aconitase with transaconitate bound 2e-43 176 binding aconitate ion 164 D 215 D 8151704 SMc03846 SMc03846 aconitate hydratase PDB 1aco:A 27.3 85 868 64 726 Crystal structure of aconitase with transaconitate bound 2e-43 176 binding aconitate ion 165 S 216 S 8151704 SMc03846 SMc03846 aconitate hydratase PDB 1aco:A 27.3 85 868 64 726 Crystal structure of aconitase with transaconitate bound 2e-43 176 binding aconitate ion 446 R 536 R 8151704 SMc03846 SMc03846 aconitate hydratase PDB 1aco:A 27.3 85 868 64 726 Crystal structure of aconitase with transaconitate bound 2e-43 176 binding aconitate ion 451 R 541 R 8151704 SMc03846 SMc03846 aconitate hydratase PDB 1aco:A 27.3 85 868 64 726 Crystal structure of aconitase with transaconitate bound 2e-43 176 binding aconitate ion 579 R 721 R 8151704 SMc03846 SMc03846 aconitate hydratase PDB 1aco:A 27.3 85 868 64 726 Crystal structure of aconitase with transaconitate bound 2e-43 176 binding aconitate ion 641 S 781 S 8151704 SMc03846 SMc03846 aconitate hydratase PDB 1aco:A 27.3 85 868 64 726 Crystal structure of aconitase with transaconitate bound 2e-43 176 binding aconitate ion 642 S 782 S 8151704 SMc03846 SMc03846 aconitate hydratase PDB 1aco:A 27.3 85 868 64 726 Crystal structure of aconitase with transaconitate bound 2e-43 176 binding aconitate ion 643 R 783 R 8151704 SMc03846 SMc03846 aconitate hydratase PDB 1nis:A 27.3 85 868 64 726 Crystal structure of aconitase with trans-aconitate and nitrocitrate bound 5e-43 175 active site 99 D 131 D 8151704 SMc03846 SMc03846 aconitate hydratase PDB 1nis:A 27.3 85 868 64 726 Crystal structure of aconitase with trans-aconitate and nitrocitrate bound 5e-43 175 active site 100 H 132 H 8151704 SMc03846 SMc03846 aconitate hydratase PDB 1nis:A 27.3 85 868 64 726 Crystal structure of aconitase with trans-aconitate and nitrocitrate bound 5e-43 175 active site 164 D 215 D 8151704 SMc03846 SMc03846 aconitate hydratase PDB 1nis:A 27.3 85 868 64 726 Crystal structure of aconitase with trans-aconitate and nitrocitrate bound 5e-43 175 active site 446 R 536 R 8151704 SMc03846 SMc03846 aconitate hydratase PDB 1nis:A 27.3 85 868 64 726 Crystal structure of aconitase with trans-aconitate and nitrocitrate bound 5e-43 175 active site 641 S 781 S 8151704 SMc03846 SMc03846 aconitate hydratase PDB 1nis:A 27.3 85 868 64 726 Crystal structure of aconitase with trans-aconitate and nitrocitrate bound 5e-43 175 active site 643 R 783 R 8151704 SMc03846 SMc03846 aconitate hydratase PDB 1nis:A 27.3 85 868 64 726 Crystal structure of aconitase with trans-aconitate and nitrocitrate bound 5e-43 175 binding 2-hydroxy-2-nitromethyl succinic acid 71 Q 92 Q 8151704 SMc03846 SMc03846 aconitate hydratase PDB 1nis:A 27.3 85 868 64 726 Crystal structure of aconitase with trans-aconitate and nitrocitrate bound 5e-43 175 binding 2-hydroxy-2-nitromethyl succinic acid 100 H 132 H 8151704 SMc03846 SMc03846 aconitate hydratase PDB 1nis:A 27.3 85 868 64 726 Crystal structure of aconitase with trans-aconitate and nitrocitrate bound 5e-43 175 binding 2-hydroxy-2-nitromethyl succinic acid 164 D 215 D 8151704 SMc03846 SMc03846 aconitate hydratase PDB 1nis:A 27.3 85 868 64 726 Crystal structure of aconitase with trans-aconitate and nitrocitrate bound 5e-43 175 binding 2-hydroxy-2-nitromethyl succinic acid 165 S 216 S 8151704 SMc03846 SMc03846 aconitate hydratase PDB 1nis:A 27.3 85 868 64 726 Crystal structure of aconitase with trans-aconitate and nitrocitrate bound 5e-43 175 binding 2-hydroxy-2-nitromethyl succinic acid 446 R 536 R 8151704 SMc03846 SMc03846 aconitate hydratase PDB 1nis:A 27.3 85 868 64 726 Crystal structure of aconitase with trans-aconitate and nitrocitrate bound 5e-43 175 binding 2-hydroxy-2-nitromethyl succinic acid 451 R 541 R 8151704 SMc03846 SMc03846 aconitate hydratase PDB 1nis:A 27.3 85 868 64 726 Crystal structure of aconitase with trans-aconitate and nitrocitrate bound 5e-43 175 binding 2-hydroxy-2-nitromethyl succinic acid 579 R 721 R 8151704 SMc03846 SMc03846 aconitate hydratase PDB 1nis:A 27.3 85 868 64 726 Crystal structure of aconitase with trans-aconitate and nitrocitrate bound 5e-43 175 binding 2-hydroxy-2-nitromethyl succinic acid 641 S 781 S 8151704 SMc03846 SMc03846 aconitate hydratase PDB 1nis:A 27.3 85 868 64 726 Crystal structure of aconitase with trans-aconitate and nitrocitrate bound 5e-43 175 binding 2-hydroxy-2-nitromethyl succinic acid 642 S 782 S 8151704 SMc03846 SMc03846 aconitate hydratase PDB 1nis:A 27.3 85 868 64 726 Crystal structure of aconitase with trans-aconitate and nitrocitrate bound 5e-43 175 binding iron/sulfur cluster 100 H 132 H 8151704 SMc03846 SMc03846 aconitate hydratase PDB 1nis:A 27.3 85 868 64 726 Crystal structure of aconitase with trans-aconitate and nitrocitrate bound 5e-43 175 binding iron/sulfur cluster 144 I 182 I 8151704 SMc03846 SMc03846 aconitate hydratase PDB 1nis:A 27.3 85 868 64 726 Crystal structure of aconitase with trans-aconitate and nitrocitrate bound 5e-43 175 binding iron/sulfur cluster 166 H 217 H 8151704 SMc03846 SMc03846 aconitate hydratase PDB 1nis:A 27.3 85 868 64 726 Crystal structure of aconitase with trans-aconitate and nitrocitrate bound 5e-43 175 binding iron/sulfur cluster 356 S 436 S 8151704 SMc03846 SMc03846 aconitate hydratase PDB 1nis:A 27.3 85 868 64 726 Crystal structure of aconitase with trans-aconitate and nitrocitrate bound 5e-43 175 binding iron/sulfur cluster 357 C 437 C 8151704 SMc03846 SMc03846 aconitate hydratase PDB 1nis:A 27.3 85 868 64 726 Crystal structure of aconitase with trans-aconitate and nitrocitrate bound 5e-43 175 binding iron/sulfur cluster 420 C 503 C 8151704 SMc03846 SMc03846 aconitate hydratase PDB 1nis:A 27.3 85 868 64 726 Crystal structure of aconitase with trans-aconitate and nitrocitrate bound 5e-43 175 binding iron/sulfur cluster 423 C 506 C 8151704 SMc03846 SMc03846 aconitate hydratase SwissProt ACON_BOVIN 26.7 50 868 53 754 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Bos taurus (Bovine) 6e-43 174 binding 99 Q 92 Q 1547214 SMc03846 SMc03846 aconitate hydratase SwissProt ACON_BOVIN 26.7 50 868 53 754 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Bos taurus (Bovine) 6e-43 174 binding 192..194 DSH 215..217 DSH 1547214 SMc03846 SMc03846 aconitate hydratase SwissProt ACON_BOVIN 26.7 50 868 53 754 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Bos taurus (Bovine) 6e-43 174 binding 385 C 437 C 1547214,3372519 SMc03846 SMc03846 aconitate hydratase SwissProt ACON_BOVIN 26.7 50 868 53 754 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Bos taurus (Bovine) 6e-43 174 binding 448 C 503 C 1547214,3372519 SMc03846 SMc03846 aconitate hydratase SwissProt ACON_BOVIN 26.7 50 868 53 754 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Bos taurus (Bovine) 6e-43 174 binding 451 C 506 C 1547214,3372519 SMc03846 SMc03846 aconitate hydratase SwissProt ACON_BOVIN 26.7 50 868 53 754 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Bos taurus (Bovine) 6e-43 174 binding 474 R 536 R 1547214 SMc03846 SMc03846 aconitate hydratase SwissProt ACON_BOVIN 26.7 50 868 53 754 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Bos taurus (Bovine) 6e-43 174 binding 479 R 541 R 1547214 SMc03846 SMc03846 aconitate hydratase SwissProt ACON_BOVIN 26.7 50 868 53 754 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Bos taurus (Bovine) 6e-43 174 binding 607 R 721 R 1547214 SMc03846 SMc03846 aconitate hydratase SwissProt ACON_BOVIN 26.7 50 868 53 754 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Bos taurus (Bovine) 6e-43 174 binding 670..671 SR 782..783 SR 1547214 SMc03846 SMc03846 aconitate hydratase PDB 5acn:A 27.3 85 868 65 727 Structure of activated aconitase. Formation of the (4fe-4s) cluster in the crystal 1e-42 173 active site 100 D 131 D 2726740 SMc03846 SMc03846 aconitate hydratase PDB 5acn:A 27.3 85 868 65 727 Structure of activated aconitase. Formation of the (4fe-4s) cluster in the crystal 1e-42 173 active site 101 H 132 H 2726740 SMc03846 SMc03846 aconitate hydratase PDB 5acn:A 27.3 85 868 65 727 Structure of activated aconitase. Formation of the (4fe-4s) cluster in the crystal 1e-42 173 active site 165 D 215 D 2726740 SMc03846 SMc03846 aconitate hydratase PDB 5acn:A 27.3 85 868 65 727 Structure of activated aconitase. Formation of the (4fe-4s) cluster in the crystal 1e-42 173 active site 447 R 536 R 2726740 SMc03846 SMc03846 aconitate hydratase PDB 5acn:A 27.3 85 868 65 727 Structure of activated aconitase. Formation of the (4fe-4s) cluster in the crystal 1e-42 173 active site 642 S 781 S 2726740 SMc03846 SMc03846 aconitate hydratase PDB 5acn:A 27.3 85 868 65 727 Structure of activated aconitase. Formation of the (4fe-4s) cluster in the crystal 1e-42 173 active site 644 R 783 R 2726740 SMc03846 SMc03846 aconitate hydratase PDB 5acn:A 27.3 85 868 65 727 Structure of activated aconitase. Formation of the (4fe-4s) cluster in the crystal 1e-42 173 binding fe3-s4 cluster 145 I 182 I 2726740 SMc03846 SMc03846 aconitate hydratase PDB 5acn:A 27.3 85 868 65 727 Structure of activated aconitase. Formation of the (4fe-4s) cluster in the crystal 1e-42 173 binding fe3-s4 cluster 147 H 184 H 2726740 SMc03846 SMc03846 aconitate hydratase PDB 5acn:A 27.3 85 868 65 727 Structure of activated aconitase. Formation of the (4fe-4s) cluster in the crystal 1e-42 173 binding fe3-s4 cluster 167 H 217 H 2726740 SMc03846 SMc03846 aconitate hydratase PDB 5acn:A 27.3 85 868 65 727 Structure of activated aconitase. Formation of the (4fe-4s) cluster in the crystal 1e-42 173 binding fe3-s4 cluster 358 C 437 C 2726740 SMc03846 SMc03846 aconitate hydratase PDB 5acn:A 27.3 85 868 65 727 Structure of activated aconitase. Formation of the (4fe-4s) cluster in the crystal 1e-42 173 binding fe3-s4 cluster 421 C 503 C 2726740 SMc03846 SMc03846 aconitate hydratase PDB 5acn:A 27.3 85 868 65 727 Structure of activated aconitase. Formation of the (4fe-4s) cluster in the crystal 1e-42 173 binding fe3-s4 cluster 424 C 506 C 2726740 SMc03846 SMc03846 aconitate hydratase PDB 5acn:A 27.3 85 868 65 727 Structure of activated aconitase. Formation of the (4fe-4s) cluster in the crystal 1e-42 173 binding fe3-s4 cluster 446 N 535 N 2726740 SMc03846 SMc03846 aconitate hydratase PDB 5acn:A 27.3 85 868 65 727 Structure of activated aconitase. Formation of the (4fe-4s) cluster in the crystal 1e-42 173 binding tricarballylic acid 198 K 248 L 2726740 SMc03846 SMc03846 aconitate hydratase PDB 5acn:A 27.3 85 868 65 727 Structure of activated aconitase. Formation of the (4fe-4s) cluster in the crystal 1e-42 173 binding tricarballylic acid 235 G 285 S 2726740 SMc03846 SMc03846 aconitate hydratase PDB 5acn:A 27.3 85 868 65 727 Structure of activated aconitase. Formation of the (4fe-4s) cluster in the crystal 1e-42 173 binding tricarballylic acid 666 R 805 R 2726740 SMc03846 SMc03846 aconitate hydratase PDB 1b0k:A 27.1 85 868 64 726 S642a:fluorocitrate complex of aconitase 2e-42 172 active site 99 D 131 D 10631981 SMc03846 SMc03846 aconitate hydratase PDB 1b0k:A 27.1 85 868 64 726 S642a:fluorocitrate complex of aconitase 2e-42 172 active site 100 H 132 H 10631981 SMc03846 SMc03846 aconitate hydratase PDB 1b0k:A 27.1 85 868 64 726 S642a:fluorocitrate complex of aconitase 2e-42 172 active site 164 D 215 D 10631981 SMc03846 SMc03846 aconitate hydratase PDB 1b0k:A 27.1 85 868 64 726 S642a:fluorocitrate complex of aconitase 2e-42 172 active site 446 R 536 R 10631981 SMc03846 SMc03846 aconitate hydratase PDB 1b0k:A 27.1 85 868 64 726 S642a:fluorocitrate complex of aconitase 2e-42 172 active site 641 A 781 S 10631981 SMc03846 SMc03846 aconitate hydratase PDB 1b0k:A 27.1 85 868 64 726 S642a:fluorocitrate complex of aconitase 2e-42 172 active site 643 R 783 R 10631981 SMc03846 SMc03846 aconitate hydratase PDB 1b0k:A 27.1 85 868 64 726 S642a:fluorocitrate complex of aconitase 2e-42 172 binding citrate anion 71 Q 92 Q 10631981 SMc03846 SMc03846 aconitate hydratase PDB 1b0k:A 27.1 85 868 64 726 S642a:fluorocitrate complex of aconitase 2e-42 172 binding citrate anion 100 H 132 H 10631981 SMc03846 SMc03846 aconitate hydratase PDB 1b0k:A 27.1 85 868 64 726 S642a:fluorocitrate complex of aconitase 2e-42 172 binding citrate anion 164 D 215 D 10631981 SMc03846 SMc03846 aconitate hydratase PDB 1b0k:A 27.1 85 868 64 726 S642a:fluorocitrate complex of aconitase 2e-42 172 binding citrate anion 165 S 216 S 10631981 SMc03846 SMc03846 aconitate hydratase PDB 1b0k:A 27.1 85 868 64 726 S642a:fluorocitrate complex of aconitase 2e-42 172 binding citrate anion 446 R 536 R 10631981 SMc03846 SMc03846 aconitate hydratase PDB 1b0k:A 27.1 85 868 64 726 S642a:fluorocitrate complex of aconitase 2e-42 172 binding citrate anion 451 R 541 R 10631981 SMc03846 SMc03846 aconitate hydratase PDB 1b0k:A 27.1 85 868 64 726 S642a:fluorocitrate complex of aconitase 2e-42 172 binding citrate anion 579 R 721 R 10631981 SMc03846 SMc03846 aconitate hydratase PDB 1b0k:A 27.1 85 868 64 726 S642a:fluorocitrate complex of aconitase 2e-42 172 binding citrate anion 641 A 781 S 10631981 SMc03846 SMc03846 aconitate hydratase PDB 1b0k:A 27.1 85 868 64 726 S642a:fluorocitrate complex of aconitase 2e-42 172 binding citrate anion 642 S 782 S 10631981 SMc03846 SMc03846 aconitate hydratase PDB 1b0k:A 27.1 85 868 64 726 S642a:fluorocitrate complex of aconitase 2e-42 172 binding citrate anion 643 R 783 R 10631981 SMc03846 SMc03846 aconitate hydratase PDB 1b0k:A 27.1 85 868 64 726 S642a:fluorocitrate complex of aconitase 2e-42 172 binding oxygen atom 164 D 215 D 10631981 SMc03846 SMc03846 aconitate hydratase PDB 1b0k:A 27.1 85 868 64 726 S642a:fluorocitrate complex of aconitase 2e-42 172 binding oxygen atom 166 H 217 H 10631981 SMc03846 SMc03846 aconitate hydratase PDB 1b0k:A 27.1 85 868 64 726 S642a:fluorocitrate complex of aconitase 2e-42 172 binding iron/sulfur cluster 100 H 132 H 10631981 SMc03846 SMc03846 aconitate hydratase PDB 1b0k:A 27.1 85 868 64 726 S642a:fluorocitrate complex of aconitase 2e-42 172 binding iron/sulfur cluster 164 D 215 D 10631981 SMc03846 SMc03846 aconitate hydratase PDB 1b0k:A 27.1 85 868 64 726 S642a:fluorocitrate complex of aconitase 2e-42 172 binding iron/sulfur cluster 166 H 217 H 10631981 SMc03846 SMc03846 aconitate hydratase PDB 1b0k:A 27.1 85 868 64 726 S642a:fluorocitrate complex of aconitase 2e-42 172 binding iron/sulfur cluster 356 S 436 S 10631981 SMc03846 SMc03846 aconitate hydratase PDB 1b0k:A 27.1 85 868 64 726 S642a:fluorocitrate complex of aconitase 2e-42 172 binding iron/sulfur cluster 357 C 437 C 10631981 SMc03846 SMc03846 aconitate hydratase PDB 1b0k:A 27.1 85 868 64 726 S642a:fluorocitrate complex of aconitase 2e-42 172 binding iron/sulfur cluster 420 C 503 C 10631981 SMc03846 SMc03846 aconitate hydratase PDB 1b0k:A 27.1 85 868 64 726 S642a:fluorocitrate complex of aconitase 2e-42 172 binding iron/sulfur cluster 423 C 506 C 10631981 SMc03846 SMc03846 aconitate hydratase SwissProt ACON_PIG 27.3 85 868 92 754 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Sus scrofa (Pig) 2e-42 172 binding 99 Q 92 Q 10631981 SMc03846 SMc03846 aconitate hydratase SwissProt ACON_PIG 27.3 85 868 92 754 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Sus scrofa (Pig) 2e-42 172 binding 192..194 DSH 215..217 DSH 10631981 SMc03846 SMc03846 aconitate hydratase SwissProt ACON_PIG 27.3 85 868 92 754 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Sus scrofa (Pig) 2e-42 172 binding 385 C 437 C 10631981,2726740 SMc03846 SMc03846 aconitate hydratase SwissProt ACON_PIG 27.3 85 868 92 754 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Sus scrofa (Pig) 2e-42 172 binding 448 C 503 C 10631981,2726740 SMc03846 SMc03846 aconitate hydratase SwissProt ACON_PIG 27.3 85 868 92 754 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Sus scrofa (Pig) 2e-42 172 binding 451 C 506 C 10631981,2726740 SMc03846 SMc03846 aconitate hydratase SwissProt ACON_PIG 27.3 85 868 92 754 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Sus scrofa (Pig) 2e-42 172 binding 474 R 536 R 10631981 SMc03846 SMc03846 aconitate hydratase SwissProt ACON_PIG 27.3 85 868 92 754 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Sus scrofa (Pig) 2e-42 172 binding 479 R 541 R 10631981 SMc03846 SMc03846 aconitate hydratase SwissProt ACON_PIG 27.3 85 868 92 754 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Sus scrofa (Pig) 2e-42 172 binding 607 R 721 R 10631981 SMc03846 SMc03846 aconitate hydratase SwissProt ACON_PIG 27.3 85 868 92 754 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Sus scrofa (Pig) 2e-42 172 binding 670..671 SR 782..783 SR 10631981 SMc03846 SMc03846 aconitate hydratase SwissProt ACON_PIG 27.3 85 868 92 754 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Sus scrofa (Pig) 2e-42 172 modified: Pyrrolidone carboxylic acid 28 2303429 SMc03846 SMc03846 aconitate hydratase SwissProt LEUC_SCHPO 25.9 210 583 135 487 3-isopropylmalate dehydratase; Alpha-IPM isomerase; IPMI; Isopropylmalate isomerase; EC 4.2.1.33 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 1e-20 100 modified: Phosphoserine 486 S 582 Q 18257517 SMc03846 SMc03846 aconitate hydratase SwissProt LEUC_SCHPO 25.9 210 583 135 487 3-isopropylmalate dehydratase; Alpha-IPM isomerase; IPMI; Isopropylmalate isomerase; EC 4.2.1.33 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 1e-20 100 modified: Phosphoserine 488 18257517 SMc03846 SMc03846 aconitate hydratase PDB 4nqy:A 25.3 161 566 70 404 The reduced form of mj0499 1e-15 84.0 active site 108 D 215 D 24699638 SMc03846 SMc03846 aconitate hydratase PDB 4nqy:A 25.3 161 566 70 404 The reduced form of mj0499 1e-15 84.0 active site 374 R 536 R 24699638 SMc03846 SMc03846 aconitate hydratase PDB 4nqy:A 25.3 161 566 70 404 The reduced form of mj0499 1e-15 84.0 binding zinc ion 351 C 503 C 24699638 SMc03846 SMc03846 aconitate hydratase PDB 4nqy:A 25.3 161 566 70 404 The reduced form of mj0499 1e-15 84.0 binding zinc ion 354 C 506 C 24699638 SMc03846 SMc03846 aconitate hydratase PDB 4nqy:A 25.3 161 566 70 404 The reduced form of mj0499 1e-15 84.0 active site 63 24699638