SitesBLAST
Comparing 14185 FitnessBrowser__Keio:14185 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
5lnxD Crystal structure of mmgc, an acyl-coa dehydrogenase from bacillus subtilis.
33% identity, 89% coverage: 38:376/380 of query aligns to 34:373/374 of 5lnxD
- active site: L122 (≠ I124), T123 (= T125), G239 (≠ E240), E358 (≠ G361), K370 (≠ R373)
- binding flavin-adenine dinucleotide: L122 (≠ I124), T123 (= T125), G128 (= G130), S129 (= S131), F153 (= F155), T155 (= T157), R265 (= R266), Q267 (= Q268), F268 (= F269), I272 (= I273), N275 (≠ F276), I278 (= I279), Q331 (= Q334), I332 (≠ V335), G335 (= G338), Y357 (≠ S360), T360 (≠ S363), E362 (= E365)
1ukwB Crystal structure of medium-chain acyl-coa dehydrogenase from thermus thermophilus hb8
30% identity, 99% coverage: 1:376/380 of query aligns to 1:377/379 of 1ukwB
- active site: L124 (≠ I124), S125 (≠ T125), T241 (≠ E240), E362 (≠ G361), R374 (= R373)
- binding cobalt (ii) ion: D145 (≠ G145), H146 (≠ K146)
- binding flavin-adenine dinucleotide: F122 (≠ S122), L124 (≠ I124), S125 (≠ T125), G130 (= G130), S131 (= S131), W155 (≠ F155), S157 (≠ T157), K200 (= K199), L357 (≠ V356), Y361 (≠ S360), E362 (≠ G361), T364 (≠ S363), E366 (= E365), L370 (= L369)
1ukwA Crystal structure of medium-chain acyl-coa dehydrogenase from thermus thermophilus hb8
30% identity, 99% coverage: 1:376/380 of query aligns to 1:377/379 of 1ukwA
- active site: L124 (≠ I124), S125 (≠ T125), T241 (≠ E240), E362 (≠ G361), R374 (= R373)
- binding flavin-adenine dinucleotide: F122 (≠ S122), L124 (≠ I124), S125 (≠ T125), G130 (= G130), S131 (= S131), W155 (≠ F155), S157 (≠ T157), L357 (≠ V356), Y361 (≠ S360), E362 (≠ G361), T364 (≠ S363), E366 (= E365), L370 (= L369)
4n5fA Crystal structure of a putative acyl-coa dehydrogenase with bound fadh2 from burkholderia cenocepacia j2315
30% identity, 98% coverage: 1:373/380 of query aligns to 2:376/378 of 4n5fA
- active site: L126 (≠ I124), T127 (= T125), G243 (≠ E240), E364 (≠ G361), R376 (= R373)
- binding dihydroflavine-adenine dinucleotide: L126 (≠ I124), T127 (= T125), G132 (= G130), S133 (= S131), F157 (= F155), T159 (= T157), T210 (≠ C207), Y363 (≠ S360), T366 (≠ S363), E368 (= E365), M372 (≠ L369)
4l1fA Electron transferring flavoprotein of acidaminococcus fermentans: towards a mechanism of flavin-based electron bifurcation (see paper)
29% identity, 99% coverage: 1:377/380 of query aligns to 1:379/380 of 4l1fA
- active site: L125 (≠ I124), T126 (= T125), G242 (≠ E240), E363 (≠ G361), R375 (= R373)
- binding coenzyme a persulfide: T132 (≠ S131), H179 (≠ P178), F232 (= F230), M236 (≠ K234), E237 (= E235), L239 (≠ F237), D240 (= D238), R243 (= R241), Y362 (≠ S360), E363 (≠ G361), G364 (= G362), R375 (= R373)
- binding flavin-adenine dinucleotide: F123 (≠ S122), L125 (≠ I124), T126 (= T125), G131 (= G130), T132 (≠ S131), F156 (= F155), I157 (= I156), T158 (= T157), R268 (= R266), Q270 (= Q268), F271 (= F269), I275 (= I273), F278 (= F276), L281 (≠ I279), Q336 (= Q334), I337 (≠ V335), G340 (= G338), I358 (≠ V356), Y362 (≠ S360), T365 (≠ S363), Q367 (≠ E365)
- binding 1,3-propandiol: L5 (= L5), Q10 (≠ E10)
5ol2F The electron transferring flavoprotein/butyryl-coa dehydrogenase complex from clostridium difficile (see paper)
29% identity, 99% coverage: 1:377/380 of query aligns to 1:378/378 of 5ol2F
- active site: L124 (≠ I124), T125 (= T125), G241 (≠ E240), G374 (≠ R373)
- binding calcium ion: E29 (= E31), E33 (≠ D35), R35 (≠ V37)
- binding coenzyme a persulfide: L238 (≠ F237), R242 (= R241), E362 (≠ G361), G363 (= G362)
- binding flavin-adenine dinucleotide: F122 (≠ S122), L124 (≠ I124), T125 (= T125), P127 (= P127), T131 (≠ S131), F155 (= F155), I156 (= I156), T157 (= T157), E198 (≠ L197), R267 (= R266), F270 (= F269), L274 (≠ I273), F277 (= F276), Q335 (= Q334), L336 (≠ V335), G338 (= G337), G339 (= G338), Y361 (≠ S360), T364 (≠ S363), E366 (= E365)
P15651 Short-chain specific acyl-CoA dehydrogenase, mitochondrial; SCAD; Butyryl-CoA dehydrogenase; EC 1.3.8.1 from Rattus norvegicus (Rat) (see 2 papers)
29% identity, 92% coverage: 30:380/380 of query aligns to 58:411/412 of P15651
Sites not aligning to the query:
- 1:24 modified: transit peptide, Mitochondrion
1jqiA Crystal structure of rat short chain acyl-coa dehydrogenase complexed with acetoacetyl-coa (see paper)
29% identity, 92% coverage: 30:380/380 of query aligns to 31:384/384 of 1jqiA
- active site: G377 (≠ R373)
- binding acetoacetyl-coenzyme a: L95 (≠ F94), F125 (≠ S122), S134 (= S131), F234 (= F230), M238 (≠ K234), Q239 (≠ E235), L241 (≠ F237), D242 (= D238), R245 (= R241), Y364 (≠ S360), E365 (≠ G361), G366 (= G362)
- binding flavin-adenine dinucleotide: F125 (≠ S122), L127 (≠ I124), S128 (≠ T125), G133 (= G130), S134 (= S131), W158 (≠ F155), T160 (= T157), R270 (= R266), F273 (= F269), L280 (≠ F276), Q338 (= Q334), I339 (≠ V335), G342 (= G338), I360 (≠ V356), T367 (≠ S363), E369 (= E365), I370 (≠ M366)
7y0aC Crystal structure of human short-chain acyl-coa dehydrogenase
30% identity, 92% coverage: 30:380/380 of query aligns to 34:387/387 of 7y0aC
- binding flavin-adenine dinucleotide: F128 (≠ S122), L130 (≠ I124), S131 (≠ T125), G136 (= G130), S137 (= S131), W161 (≠ F155), T163 (= T157), T214 (≠ C207), R273 (= R266), F276 (= F269), L280 (≠ I273), L283 (≠ F276), V285 (≠ L278), Q341 (= Q334), I342 (≠ V335), G345 (= G338), I363 (≠ V356), Y367 (≠ S360), T370 (≠ S363), E372 (= E365), L376 (= L369)
7y0bA Crystal structure of human short-chain acyl-coa dehydrogenase
30% identity, 92% coverage: 30:380/380 of query aligns to 31:384/385 of 7y0bA
- binding (2S,3R,4R,5S,6R)-2-[4-chloranyl-3-[[4-[(3S)-oxolan-3-yl]oxyphenyl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol: M343 (≠ V339), T347 (≠ G343), E348 (≠ N344)
- binding flavin-adenine dinucleotide: F125 (≠ S122), L127 (≠ I124), S128 (≠ T125), G133 (= G130), S134 (= S131), W158 (≠ F155), T160 (= T157), R270 (= R266), F273 (= F269), L280 (≠ F276), V282 (≠ L278), Q338 (= Q334), I339 (≠ V335), G342 (= G338), I360 (≠ V356), Y364 (≠ S360), T367 (≠ S363), E369 (= E365), I370 (≠ M366), L373 (= L369)
8sgsA Short-chain specific acyl-CoA dehydrogenase, mitochondrial (see paper)
30% identity, 92% coverage: 30:380/380 of query aligns to 28:381/381 of 8sgsA
- binding coenzyme a: S131 (= S131), A133 (≠ V133), N177 (≠ K177), F231 (= F230), M235 (≠ K234), L238 (≠ F237), I312 (≠ S311), E362 (≠ G361), G363 (= G362)
- binding flavin-adenine dinucleotide: F122 (≠ S122), L124 (≠ I124), S125 (≠ T125), G130 (= G130), S131 (= S131), W155 (≠ F155), T157 (= T157), R267 (= R266), F270 (= F269), L274 (≠ I273), L277 (≠ F276), Q335 (= Q334), I336 (≠ V335), G338 (= G337), G339 (= G338), I357 (≠ V356), I360 (≠ V359), Y361 (≠ S360), T364 (≠ S363), E366 (= E365)
P16219 Short-chain specific acyl-CoA dehydrogenase, mitochondrial; SCAD; Butyryl-CoA dehydrogenase; EC 1.3.8.1 from Homo sapiens (Human) (see 3 papers)
30% identity, 92% coverage: 30:380/380 of query aligns to 58:411/412 of P16219
- G90 (= G62) to S: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs121908005
- E104 (= E76) natural variant: Missing (in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs387906308)
- 152:161 (vs. 122:131, 60% identical) binding in other chain
- R171 (≠ T141) to W: 69% of wild-type acyl-CoA dehydrogenase activity; confers susceptibility to ethylmalonicaciduria; dbSNP:rs1800556
- WIT 185:187 (≠ FIT 155:157) binding in other chain
- A192 (≠ T162) to V: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs28940874
- G209 (≠ V179) to S: 86% of wild-type acyl-CoA dehydrogenase activity; confers susceptibility to ethylmalonicaciduria; dbSNP:rs1799958
- R297 (= R266) binding
- Q308 (= Q277) binding in other chain
- R325 (≠ K294) to W: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs121908006
- S353 (≠ A322) to L: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs28941773
- QILGG 365:369 (≠ QVLGG 334:338) binding
- R380 (= R349) to W: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs28940875
- TSE 394:396 (≠ SDE 363:365) binding in other chain
Sites not aligning to the query:
- 1:24 modified: transit peptide, Mitochondrion
7p9xA Structure of cyclohex-1-ene-1-carboxyl-coa dehydrogenase complexed with cyclohex-1-ene-1-carboxyl-coa (see paper)
30% identity, 98% coverage: 4:376/380 of query aligns to 1:376/378 of 7p9xA
- binding 1-monoenoyl-CoA: L82 (≠ Y85), D89 (≠ G92), S129 (= S131), L131 (≠ V133), K176 (≠ P178), F229 (= F230), M233 (≠ K234), L236 (≠ F237), R240 (= R241), Y360 (≠ S360), T361 (≠ G361), G362 (= G362), R373 (= R373)
- binding flavin-adenine dinucleotide: A122 (≠ I124), T123 (= T125), G128 (= G130), S129 (= S131), F153 (= F155), I154 (= I156), T155 (= T157), N206 (≠ C207), L356 (≠ V356), Y360 (≠ S360), T363 (≠ S363), Q365 (≠ E365), I366 (≠ M366)
7p9aA Structure of cyclohex-1-ene-1-carboxyl-coa dehydrogenase complexed with cyclohex-1,5-diene-1-carboxyl-coa (see paper)
30% identity, 98% coverage: 4:376/380 of query aligns to 3:378/380 of 7p9aA
- binding 1,5 Dienoyl-CoA: S131 (= S131), L133 (≠ V133), K178 (≠ P178), F231 (= F230), M235 (≠ K234), L238 (≠ F237), N241 (≠ E240), R242 (= R241), Y362 (≠ S360), T363 (≠ G361), G364 (= G362), R375 (= R373)
- binding flavin-adenine dinucleotide: L122 (≠ S122), A124 (≠ I124), T125 (= T125), G130 (= G130), S131 (= S131), F155 (= F155), I156 (= I156), T157 (= T157), K200 (= K199), N208 (≠ C207), L358 (≠ V356), T365 (≠ S363), Q367 (≠ E365), I368 (≠ M366)
2dvlA Crystal structure of project tt0160 from thermus thermophilus hb8
33% identity, 98% coverage: 5:377/380 of query aligns to 1:370/370 of 2dvlA
- active site: L121 (≠ I124), T122 (= T125), G233 (≠ E240), E354 (≠ G361), R366 (= R373)
- binding flavin-adenine dinucleotide: L121 (≠ I124), T122 (= T125), G127 (= G130), S128 (= S131), W152 (≠ F155), I153 (= I156), T154 (= T157), T356 (≠ S363), E358 (= E365)
6fahD Molecular basis of the flavin-based electron-bifurcating caffeyl-coa reductase reaction (see paper)
30% identity, 92% coverage: 31:378/380 of query aligns to 29:379/379 of 6fahD
- active site: L124 (≠ I124), T125 (= T125), G241 (≠ E240), G374 (≠ R373)
- binding flavin-adenine dinucleotide: F122 (≠ S122), L124 (≠ I124), T125 (= T125), R152 (≠ S152), F155 (= F155), T157 (= T157), E198 (= E198), R267 (= R266), Q269 (= Q268), F270 (= F269), I274 (= I273), F277 (= F276), Q335 (= Q334), I336 (≠ V335), G339 (= G338), Y361 (≠ S360), T364 (≠ S363), Q366 (≠ E365)
1bucA Three-dimensional structure of butyryl-coa dehydrogenase from megasphaera elsdenii (see paper)
29% identity, 99% coverage: 1:377/380 of query aligns to 1:383/383 of 1bucA
- active site: L128 (≠ I124), T129 (= T125), G246 (≠ E240), E367 (≠ G361), G379 (≠ R373)
- binding acetoacetyl-coenzyme a: L96 (≠ F94), F126 (≠ S122), G134 (= G130), T135 (≠ S131), T162 (= T157), N182 (≠ K177), H183 (≠ P178), F236 (= F230), M240 (≠ K234), M241 (≠ E235), L243 (≠ F237), D244 (= D238), T317 (≠ S311), Y366 (≠ S360), E367 (≠ G361), G368 (= G362)
- binding flavin-adenine dinucleotide: F126 (≠ S122), L128 (≠ I124), T129 (= T125), G134 (= G130), T135 (≠ S131), F160 (= F155), T162 (= T157), Y366 (≠ S360), T369 (≠ S363), E371 (= E365), M375 (≠ L369)
Q06319 Acyl-CoA dehydrogenase, short-chain specific; Butyryl-CoA dehydrogenase; BCAD; SCAD; EC 1.3.8.1 from Megasphaera elsdenii (see paper)
29% identity, 99% coverage: 1:377/380 of query aligns to 1:383/383 of Q06319
- E367 (≠ G361) active site, Proton acceptor; mutation to Q: Loss of activity.
2vigB Crystal structure of human short-chain acyl coa dehydrogenase
30% identity, 92% coverage: 30:380/380 of query aligns to 25:371/371 of 2vigB
- active site: L121 (≠ I124), S122 (≠ T125), G231 (≠ E240), E352 (≠ G361), G364 (≠ R373)
- binding coenzyme a persulfide: S128 (= S131), F221 (= F230), M225 (≠ K234), Q226 (≠ E235), L228 (≠ F237), D229 (= D238), R232 (= R241), E352 (≠ G361), G353 (= G362), I357 (≠ M366)
- binding flavin-adenine dinucleotide: L121 (≠ I124), S122 (≠ T125), G127 (= G130), S128 (= S131), W152 (≠ F155), T154 (= T157), R257 (= R266), F260 (= F269), L264 (≠ I273), L267 (≠ F276), Q325 (= Q334), I326 (≠ V335), G329 (= G338), I347 (≠ V356), Y351 (≠ S360), T354 (≠ S363), E356 (= E365)
2jifA Structure of human short-branched chain acyl-coa dehydrogenase (acadsb)
27% identity, 99% coverage: 4:379/380 of query aligns to 5:381/381 of 2jifA
- active site: L125 (≠ I124), S126 (≠ T125), G242 (≠ E240), E363 (≠ G361), K375 (≠ R373)
- binding coenzyme a persulfide: S132 (= S131), S134 (≠ V133), Y178 (≠ K177), Y232 (≠ F230), I236 (≠ K234), L239 (≠ F237), N240 (≠ D238), R243 (= R241), Y362 (≠ S360), E363 (≠ G361), G364 (= G362), I368 (≠ M366)
- binding flavin-adenine dinucleotide: F123 (≠ S122), L125 (≠ I124), S126 (≠ T125), G131 (= G130), S132 (= S131), W156 (≠ F155), I157 (= I156), S158 (≠ T157), K201 (= K199), T209 (≠ C207), R268 (= R266), F271 (= F269), L275 (≠ I273), F278 (= F276), L281 (≠ I279), E336 (≠ Q334), W337 (≠ V335), G340 (= G338), N367 (≠ E365), I368 (≠ M366)
Query Sequence
>14185 FitnessBrowser__Keio:14185
MDFNLNDEQELFVAGIRELMASENWEAYFAECDRDSVYPERFVKALADMGIDSLLIPEEH
GGLDAGFVTLAAVWMELGRLGAPTYVLYQLPGGFNTFLREGTQEQIDKIMAFRGTGKQMW
NSAITEPGAGSDVGSLKTTYTRRNGKIYLNGSKCFITSSAYTPYIVVMARDGASPDKPVY
TEWFVDMSKPGIKVTKLEKLGLRMDSCCEITFDDVELDEKDMFGREGNGFNRVKEEFDHE
RFLVALTNYGTAMCAFEDAARYANQRVQFGEAIGRFQLIQEKFAHMAIKLNSMKNMLYEA
AWKADNGTITSGDAAMCKYFCANAAFEVVDSAMQVLGGVGIAGNHRISRFWRDLRVDRVS
GGSDEMQILTLGRAVLKQYR
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory