Comparing 14209 FitnessBrowser__Keio:14209 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
3qdkA Structural insight on mechanism and diverse substrate selection strategy of ribulokinase (see paper)
33% identity, 95% coverage: 5:539/566 of query aligns to 4:524/546 of 3qdkA
3l0qA The crystal structure of xlylulose kinase from yersinia pseudotuberculosis
26% identity, 82% coverage: 80:541/566 of query aligns to 72:528/541 of 3l0qA
Q5HGD2 Glycerol kinase; ATP:glycerol 3-phosphotransferase; Glycerokinase; GK; EC 2.7.1.30 from Staphylococcus aureus (strain COL)
28% identity, 27% coverage: 398:550/566 of query aligns to 347:495/498 of Q5HGD2
Sites not aligning to the query:
3ge1A 2.7 angstrom crystal structure of glycerol kinase (glpk) from staphylococcus aureus in complex with adp and glycerol
28% identity, 27% coverage: 398:550/566 of query aligns to 348:496/499 of 3ge1A
Sites not aligning to the query:
P18157 Glycerol kinase; ATP:glycerol 3-phosphotransferase; Glycerokinase; GK; EC 2.7.1.30 from Bacillus subtilis (strain 168) (see paper)
25% identity, 29% coverage: 377:541/566 of query aligns to 326:487/496 of P18157
Sites not aligning to the query:
O34154 Glycerol kinase; ATP:glycerol 3-phosphotransferase; Glycerokinase; GK; EC 2.7.1.30 from Enterococcus faecalis (strain ATCC 700802 / V583) (see 2 papers)
27% identity, 31% coverage: 377:550/566 of query aligns to 327:496/501 of O34154
Sites not aligning to the query:
1gllO Escherichia coli glycerol kinase mutant with bound atp analog showing substantial domain motion (see paper)
26% identity, 27% coverage: 398:549/566 of query aligns to 343:494/494 of 1gllO
Sites not aligning to the query:
1gljO Escherichia coli glycerol kinase mutant with bound atp analog showing substantial domain motion (see paper)
26% identity, 27% coverage: 398:549/566 of query aligns to 343:494/494 of 1gljO
Sites not aligning to the query:
1bwfO Escherichia coli glycerol kinase mutant with bound atp analog showing substantial domain motion (see paper)
26% identity, 27% coverage: 398:549/566 of query aligns to 343:494/494 of 1bwfO
Sites not aligning to the query:
P0A6F3 Glycerol kinase; ATP:glycerol 3-phosphotransferase; Glycerokinase; GK; EC 2.7.1.30 from Escherichia coli (strain K12) (see 10 papers)
26% identity, 27% coverage: 398:549/566 of query aligns to 349:500/502 of P0A6F3
Sites not aligning to the query:
1bu6Y Crystal structures of escherichia coli glycerol kinase and the mutant a65t in an inactive tetramer: conformational changes and implications for allosteric regulation (see paper)
26% identity, 27% coverage: 398:549/566 of query aligns to 347:498/499 of 1bu6Y
Sites not aligning to the query:
1gldG Cation promoted association (cpa) of a regulatory and target protein is controlled by phosphorylation (see paper)
26% identity, 27% coverage: 398:549/566 of query aligns to 338:489/489 of 1gldG
Sites not aligning to the query:
1glcG Cation promoted association (cpa) of a regulatory and target protein is controlled by phosphorylation (see paper)
26% identity, 27% coverage: 398:549/566 of query aligns to 338:489/489 of 1glcG
Sites not aligning to the query:
1glbG Structure of the regulatory complex of escherichia coli iiiglc with glycerol kinase (see paper)
26% identity, 27% coverage: 398:549/566 of query aligns to 338:489/489 of 1glbG
Sites not aligning to the query:
1glfO Crystal structures of escherichia coli glycerol kinase and the mutant a65t in an inactive tetramer: conformational changes and implications for allosteric regulation (see paper)
26% identity, 27% coverage: 398:549/566 of query aligns to 347:498/498 of 1glfO
Sites not aligning to the query:
1bo5O Crystal structure of the complex between escherichia coli glycerol kinase and the allosteric regulator fructose 1,6-bisphosphate. (see paper)
26% identity, 27% coverage: 398:549/566 of query aligns to 347:498/498 of 1bo5O
Sites not aligning to the query:
2w41B Crystal structure of plasmodium falciparum glycerol kinase with adp (see paper)
24% identity, 20% coverage: 398:511/566 of query aligns to 356:470/507 of 2w41B
Sites not aligning to the query:
2w40A Crystal structure of plasmodium falciparum glycerol kinase with bound glycerol (see paper)
24% identity, 20% coverage: 398:511/566 of query aligns to 350:464/501 of 2w40A
Sites not aligning to the query:
O34153 Glycerol kinase; ATP:glycerol 3-phosphotransferase; Glycerokinase; GK; EC 2.7.1.30 from Enterococcus casseliflavus (Enterococcus flavescens) (see 3 papers)
25% identity, 30% coverage: 379:550/566 of query aligns to 330:497/506 of O34153
Sites not aligning to the query:
3h3nX Glycerol kinase h232r with glycerol (see paper)
25% identity, 30% coverage: 379:550/566 of query aligns to 329:496/501 of 3h3nX
Sites not aligning to the query:
>14209 FitnessBrowser__Keio:14209
MAIAIGLDFGSDSVRALAVDCATGEEIATSVEWYPRWQKGQFCDAPNNQFRHHPRDYIES
MEAALKTVLAELSVEQRAAVVGIGVDSTGSTPAPIDADGNVLALRPEFAENPNAMFVLWK
DHTAVEEAEEITRLCHAPGNVDYSRYIGGIYSSEWFWAKILHVTRQDSAVAQSAASWIEL
CDWVPALLSGTTRPQDIRRGRCSAGHKSLWHESWGGLPPASFFDELDPILNRHLPSPLFT
DTWTADIPVGTLCPEWAQRLGLPESVVISGGAFDCHMGAVGAGAQPNALVKVIGTSTCDI
LIADKQSVGERAVKGICGQVDGSVVPGFIGLEAGQSAFGDIYAWFGRVLGWPLEQLAAQH
PELKTQINASQKQLLPALTEAWAKNPSLDHLPVVLDWFNGRRTPNANQRLKGVITDLNLA
TDAPLLFGGLIAATAFGARAIMECFTDQGIAVNNVMALGGIARKNQVIMQACCDVLNRPL
QIVASDQCCALGAAIFAAVAAKVHADIPSAQQKMASAVEKTLQPCSEQAQRFEQLYRRYQ
QWAMSAEQHYLPTSAPAQAAQAVATL
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory