SitesBLAST – Find functional sites

 

SitesBLAST

Comparing 14217 b0071 isopropylmalate isomerase small subunit (NCBI) to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 4 hits to proteins with known functional sites (download)

O14289 3-isopropylmalate dehydratase; Alpha-IPM isomerase; IPMI; Isopropylmalate isomerase; EC 4.2.1.33 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
50% identity, 96% coverage: 4:196/201 of query aligns to 539:727/758 of O14289

query
sites
O14289
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R

Sites not aligning to the query:

P9WK95 3-isopropylmalate dehydratase small subunit; Alpha-IPM isomerase; IPMI; Isopropylmalate isomerase; EC 4.2.1.33 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
43% identity, 96% coverage: 3:194/201 of query aligns to 2:185/198 of P9WK95

query
sites
P9WK95
E
 
E
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A
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G

Q58667 Methanogen homoaconitase small subunit; HACN; Homoaconitate hydratase; EC 4.2.1.114 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
35% identity, 67% coverage: 19:153/201 of query aligns to 13:125/170 of Q58667

query
sites
Q58667
N
 
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I

2pkpA Crystal structure of 3-isopropylmalate dehydratase (leud)from methhanocaldococcus jannaschii dsm2661 (mj1271) (see paper)
35% identity, 67% coverage: 19:153/201 of query aligns to 13:125/167 of 2pkpA

query
sites
2pkpA
N
x
D
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V
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D
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D
A
 
A
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I
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I
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P
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G
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P
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Y
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L
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R
K
 
T
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T
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D
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P
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Y
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E
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L
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A
A
 
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C
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M
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A
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G
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-
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E
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-
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-
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N
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F
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K
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K
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G
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E
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N
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F
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G
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C
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R
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E
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A
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I
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A
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K
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S
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F
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A
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I
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F
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Y
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N
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A
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I
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N
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L
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P
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-
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-
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-
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-
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I

Query Sequence

>14217 b0071 isopropylmalate isomerase small subunit (NCBI)
MAEKFIKHTGLVVPLDAANVDTDAIIPKQFLQKVTRTGFGAHLFNDWRFLDEKGQQPNPD
FVLNFPQYQGASILLARENFGCGSSREHAPWALTDYGFKVVIAPSFADIFYGNSFNNQLL
PVKLSDAEVDELFALVKANPGIHFDVDLEAQEVKAGEKTYRFTIDAFRRHCMMNGLDSIG
LTLQHDDAIAAYEAKQPAFMN

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory