Comparing 14461 FitnessBrowser__Keio:14461 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 10 hits to proteins with known functional sites (download)
1e19A Structure of the carbamate kinase-like carbamoyl phosphate synthetase from the hyperthermophilic archaeon pyrococcus furiosus bound to adp (see paper)
44% identity, 98% coverage: 5:314/316 of query aligns to 4:312/313 of 1e19A
P0A2X8 Carbamate kinase 1; EC 2.7.2.2 from Enterococcus faecium (Streptococcus faecium) (see 2 papers)
46% identity, 95% coverage: 1:301/316 of query aligns to 1:295/310 of P0A2X8
2we5A Carbamate kinase from enterococcus faecalis bound to mgadp (see paper)
46% identity, 94% coverage: 5:301/316 of query aligns to 4:294/309 of 2we5A
2we4A Carbamate kinase from enterococcus faecalis bound to a sulfate ion and two water molecules, which mimic the substrate carbamyl phosphate (see paper)
46% identity, 94% coverage: 5:301/316 of query aligns to 4:294/309 of 2we4A
Sites not aligning to the query:
4jz8A Carbamate kinase from giardia lamblia bound to citric acid (see paper)
41% identity, 98% coverage: 5:315/316 of query aligns to 7:315/316 of 4jz8A
4jz7C Carbamate kinase from giardia lamblia bound to amp-pnp (see paper)
41% identity, 98% coverage: 5:315/316 of query aligns to 7:315/316 of 4jz7C
4olcA Carbamate kinase from giardia lamblia thiocarbamoylated by disulfiram on cys242 (see paper)
40% identity, 98% coverage: 5:315/316 of query aligns to 6:307/308 of 4olcA
8crvA Crystal structure of the carbamate kinase from pseudomonas aeruginosa
40% identity, 98% coverage: 5:313/316 of query aligns to 5:302/312 of 8crvA
4jz7A Carbamate kinase from giardia lamblia bound to amp-pnp (see paper)
37% identity, 98% coverage: 5:315/316 of query aligns to 7:284/285 of 4jz7A
4axsA Structure of carbamate kinase from mycoplasma penetrans (see paper)
38% identity, 98% coverage: 5:314/316 of query aligns to 2:290/291 of 4axsA
>14461 FitnessBrowser__Keio:14461
MKELVVVAIGGNSIIKDNASQSIEHQAEAVKAVADTVLEMLASDYDIVLTHGNGPQVGLD
LRRAEIAHKREGLPLTPLANCVADTQGGIGYLIQQALNNRLARHGEKKAVTVVTQVEVDK
NDPGFAHPTKPIGAFFSDSQRDELQKANPDWCFVEDAGRGYRRVVASPEPKRIVEAPAIK
ALIQQGFVVIGAGGGGIPVVRTDAGDYQSVDAVIDKDLSTALLAREIHADILVITTGVEK
VCIHFGKPQQQALDRVDIATMTRYMQEGHFPPGSMLPKIIASLTFLEQGGKEVIITTPEC
LPAALRGETGTHIIKT
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory