SitesBLAST
Comparing 15420 b1300 gamma-Glu-gamma-aminobutyraldehyde dehydrogenase, NAD(P)H-dependent (NCBI) to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
5iuwA Crystal structure of indole-3-acetaldehyde dehydrogenase in complexed with NAD+ and iaa (see paper)
58% identity, 98% coverage: 7:493/495 of query aligns to 5:495/495 of 5iuwA
- active site: N166 (= N168), K189 (= K191), E265 (= E267), C300 (= C302), E399 (= E397), D476 (= D474)
- binding 1h-indol-3-ylacetic acid: F167 (= F169), M170 (≠ L172), C300 (= C302), D457 (≠ N455), F465 (= F463)
- binding nicotinamide-adenine-dinucleotide: I162 (= I164), V163 (= V165), P164 (= P166), W165 (= W167), N166 (= N168), K189 (= K191), G222 (= G224), G226 (= G228), K227 (≠ Q229), F240 (= F242), T241 (= T243), G242 (= G244), S243 (= S245), I246 (≠ T248), Y253 (≠ D255), E265 (= E267), A266 (= A268), C300 (= C302), E399 (= E397), F401 (= F399)
5iuvA Crystal structure of indole-3-acetaldehyde dehydrogenase in complexed with NAD+ (see paper)
58% identity, 98% coverage: 7:493/495 of query aligns to 5:495/495 of 5iuvA
- active site: N166 (= N168), K189 (= K191), E265 (= E267), C300 (= C302), E399 (= E397), D476 (= D474)
- binding nicotinamide-adenine-dinucleotide: I162 (= I164), V163 (= V165), P164 (= P166), W165 (= W167), N166 (= N168), K189 (= K191), S191 (= S193), G222 (= G224), G226 (= G228), K227 (≠ Q229), F240 (= F242), T241 (= T243), G242 (= G244), S243 (= S245), I246 (≠ T248), Y253 (≠ D255), E265 (= E267), A266 (= A268), C300 (= C302), E399 (= E397), F401 (= F399)
7jsoA P. Syringae alda indole-3-acetaldehyde dehydrogenase c302a mutant in complex with NAD+ and iaa (see paper)
58% identity, 98% coverage: 7:493/495 of query aligns to 5:495/495 of 7jsoA
- active site: N166 (= N168), E265 (= E267), A300 (≠ C302), D476 (= D474)
- binding 1h-indol-3-ylacetic acid: F167 (= F169), W174 (= W176), V299 (= V301), A300 (≠ C302), T301 (≠ I303), D457 (≠ N455), F465 (= F463)
- binding 1,4-dihydronicotinamide adenine dinucleotide: I162 (= I164), V163 (= V165), P164 (= P166), W165 (= W167), K189 (= K191), E192 (= E194), G222 (= G224), G226 (= G228), K227 (≠ Q229), F240 (= F242), G242 (= G244), S243 (= S245), I246 (≠ T248), A266 (= A268), G267 (= G269), A300 (≠ C302), E399 (= E397), F401 (= F399)
5gtlA NADPH complex structure of aldehyde dehydrogenase from bacillus cereus
43% identity, 96% coverage: 19:494/495 of query aligns to 16:491/491 of 5gtlA
- active site: N165 (= N168), K188 (= K191), E263 (= E267), C297 (= C302), E394 (= E397), E471 (≠ D474)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: I161 (= I164), P163 (= P166), K188 (= K191), A190 (≠ S193), E191 (= E194), Q192 (≠ K195), G221 (= G224), G225 (= G228), G241 (= G244), S242 (= S245), T245 (= T248), L264 (≠ A268), C297 (= C302), E394 (= E397), F396 (= F399)
5gtkA NAD+ complex structure of aldehyde dehydrogenase from bacillus cereus
43% identity, 96% coverage: 19:494/495 of query aligns to 16:491/491 of 5gtkA
- active site: N165 (= N168), K188 (= K191), E263 (= E267), C297 (= C302), E394 (= E397), E471 (≠ D474)
- binding nicotinamide-adenine-dinucleotide: I161 (= I164), I162 (≠ V165), P163 (= P166), W164 (= W167), K188 (= K191), E191 (= E194), G221 (= G224), G225 (= G228), A226 (≠ Q229), F239 (= F242), G241 (= G244), S242 (= S245), T245 (= T248), Y248 (≠ Q251), L264 (≠ A268), C297 (= C302), Q344 (≠ H349), R347 (≠ S352), E394 (= E397), F396 (= F399)
7uyyA The crystal structure of the pseudomonas aeruginosa aldehyde dehydrogenase encoded by the pa4189 gene in complex with nadh (see paper)
45% identity, 97% coverage: 13:491/495 of query aligns to 14:493/496 of 7uyyA
- binding 1,4-dihydronicotinamide adenine dinucleotide: V165 (≠ I164), L166 (≠ V165), P167 (= P166), W168 (= W167), K192 (= K191), G225 (= G224), G229 (= G228), F243 (= F242), G245 (= G244), S246 (= S245), T249 (= T248), L252 (≠ Q251), F253 (≠ L252), Y256 (≠ D255), C269 (≠ A268), G270 (= G269), C303 (= C302), H350 (= H349), K353 (≠ S352), F400 (= F399)
4o6rA Crystal structure of a putative aldehyde dehydrogenase from burkholderia cenocepacia
43% identity, 96% coverage: 18:494/495 of query aligns to 2:480/489 of 4o6rA
- active site: N150 (= N168), K173 (= K191), E248 (= E267), C282 (= C302), E383 (= E397), E460 (≠ D474)
- binding adenosine monophosphate: I146 (= I164), V147 (= V165), K173 (= K191), G206 (= G224), G210 (= G228), Q211 (= Q229), F224 (= F242), G226 (= G244), S227 (= S245), T230 (= T248), R233 (≠ Q251)
7radA Crystal structure analysis of aldh1b1
43% identity, 96% coverage: 20:493/495 of query aligns to 13:488/493 of 7radA
- binding nicotinamide-adenine-dinucleotide: I158 (= I164), I159 (≠ V165), P160 (= P166), W161 (= W167), N162 (= N168), M167 (≠ L173), K185 (= K191), E188 (= E194), G218 (= G224), G222 (= G228), A223 (≠ Q229), T237 (= T243), G238 (= G244), S239 (= S245), V242 (≠ T248), E261 (= E267), L262 (≠ A268), C295 (= C302), E392 (= E397), F394 (= F399)
- binding 3-(2-methoxyphenyl)-1-(4-phenylphenyl)-6,7,8,9-tetrahydro-5~{H}-imidazo[1,2-a][1,3]diazepine: L113 (≠ D119), E117 (≠ G123), F163 (= F169), E285 (≠ A292), F289 (≠ Y296), N450 (= N455), V452 (≠ G457)
7mjdA Crystal structure analysis of aldh1b1
43% identity, 96% coverage: 20:493/495 of query aligns to 13:488/493 of 7mjdA
- binding nicotinamide-adenine-dinucleotide: I158 (= I164), I159 (≠ V165), P160 (= P166), W161 (= W167), N162 (= N168), M167 (≠ L173), K185 (= K191), E188 (= E194), G218 (= G224), G222 (= G228), F236 (= F242), T237 (= T243), G238 (= G244), S239 (= S245), V242 (≠ T248), E261 (= E267), L262 (≠ A268), C295 (= C302), E392 (= E397), F394 (= F399)
- binding 8-(2-methoxyphenyl)-10-(4-phenylphenyl)-1$l^{4},8-diazabicyclo[5.3.0]deca-1(7),9-diene: E117 (≠ G123), E285 (≠ A292), F289 (≠ Y296), N450 (= N455), V452 (≠ G457)
7mjcA Crystal structure analysis of aldh1b1
43% identity, 96% coverage: 20:493/495 of query aligns to 13:488/493 of 7mjcA
- binding nicotinamide-adenine-dinucleotide: I158 (= I164), I159 (≠ V165), P160 (= P166), W161 (= W167), N162 (= N168), K185 (= K191), E188 (= E194), G218 (= G224), G222 (= G228), T237 (= T243), G238 (= G244), S239 (= S245), V242 (≠ T248), E261 (= E267), L262 (≠ A268), C295 (= C302), E392 (= E397), F394 (= F399)
4pz2B Structure of zm aldh2-6 (rf2f) in complex with NAD (see paper)
42% identity, 96% coverage: 20:495/495 of query aligns to 11:490/494 of 4pz2B
- active site: N159 (= N168), K182 (= K191), E258 (= E267), C292 (= C302), E392 (= E397), D469 (= D474)
- binding nicotinamide-adenine-dinucleotide: I155 (= I164), I156 (≠ V165), P157 (= P166), W158 (= W167), N159 (= N168), M164 (≠ L173), K182 (= K191), A184 (≠ S193), E185 (= E194), G215 (= G224), G219 (= G228), F233 (= F242), T234 (= T243), G235 (= G244), S236 (= S245), V239 (≠ T248), E258 (= E267), L259 (≠ A268), C292 (= C302), E392 (= E397), F394 (= F399)
4go4A Crystal structure of pnpe in complex with nicotinamide adenine dinucleotide
43% identity, 97% coverage: 18:495/495 of query aligns to 1:479/487 of 4go4A
- active site: N149 (= N168), K172 (= K191), E247 (= E267), C281 (= C302), E381 (= E397), E458 (≠ D474)
- binding nicotinamide-adenine-dinucleotide: I145 (= I164), V146 (= V165), W148 (= W167), N149 (= N168), F154 (≠ L173), K172 (= K191), G205 (= G224), G209 (= G228), Q210 (= Q229), F223 (= F242), T224 (= T243), G225 (= G244), S226 (= S245), T229 (= T248), E247 (= E267), G249 (= G269), C281 (= C302), E381 (= E397), F383 (= F399)
4pxlA Structure of zm aldh2-3 (rf2c) in complex with NAD (see paper)
42% identity, 96% coverage: 20:493/495 of query aligns to 6:480/486 of 4pxlA
- active site: N154 (= N168), K177 (= K191), E253 (= E267), C287 (= C302), E384 (= E397), D461 (= D474)
- binding nicotinamide-adenine-dinucleotide: I150 (= I164), V151 (= V165), P152 (= P166), W153 (= W167), K177 (= K191), E180 (= E194), G210 (= G224), G214 (= G228), A215 (≠ Q229), F228 (= F242), G230 (= G244), S231 (= S245), V234 (≠ T248), E253 (= E267), G255 (= G269), C287 (= C302), Q334 (≠ H349), K337 (≠ S352), E384 (= E397), F386 (= F399)
Q56YU0 Aldehyde dehydrogenase family 2 member C4; ALDH1a; Protein REDUCED EPIDERMAL FLUORESCENCE 1; EC 1.2.1.3 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
40% identity, 96% coverage: 21:493/495 of query aligns to 21:495/501 of Q56YU0
- G152 (≠ A151) mutation to E: In ref1-7; reduced activity on sinapaldehyde.
- G416 (≠ A414) mutation to R: In ref1-6; reduced activity on sinapaldehyde.
5l13A Structure of aldh2 in complex with 2p3 (see paper)
43% identity, 96% coverage: 20:493/495 of query aligns to 14:489/494 of 5l13A
- active site: N163 (= N168), K186 (= K191), E262 (= E267), C296 (= C302), E393 (= E397), E470 (≠ D474)
- binding 2,3,5-trimethyl-6-propyl-7H-furo[3,2-g][1]benzopyran-7-one: F164 (= F169), M168 (≠ L173), W171 (= W176), F290 (≠ Y296), C295 (≠ V301), C296 (= C302), C297 (≠ I303), D451 (≠ N455), F453 (≠ G457)
4kwgA Crystal structure analysis of aldh2+aldib13 (see paper)
43% identity, 96% coverage: 20:493/495 of query aligns to 14:489/494 of 4kwgA
- active site: N163 (= N168), K186 (= K191), E262 (= E267), C296 (= C302), E393 (= E397), E470 (≠ D474)
- binding 7-bromo-5-methyl-1H-indole-2,3-dione: F164 (= F169), M168 (≠ L173), C295 (≠ V301), C296 (= C302), C297 (≠ I303), D451 (≠ N455), F453 (≠ G457)
4kwfA Crystal structure analysis of aldh2+aldib33 (see paper)
43% identity, 96% coverage: 20:493/495 of query aligns to 14:489/494 of 4kwfA
- active site: N163 (= N168), K186 (= K191), E262 (= E267), C296 (= C302), E393 (= E397), E470 (≠ D474)
- binding 1-benzyl-1H-indole-2,3-dione: F164 (= F169), M168 (≠ L173), W171 (= W176), E262 (= E267), C295 (≠ V301), C296 (= C302), C297 (≠ I303), D451 (≠ N455), F453 (≠ G457), F459 (= F463)
3sz9A Crystal structure of human aldh2 modified with the beta-elimination product of aldi-3; 1-(4-ethylbenzene)prop-2-en-1-one (see paper)
43% identity, 96% coverage: 20:493/495 of query aligns to 14:489/494 of 3sz9A
- active site: N163 (= N168), K186 (= K191), E262 (= E267), C296 (= C302), E393 (= E397), E470 (≠ D474)
- binding 1-(4-ethylphenyl)propan-1-one: F164 (= F169), C295 (≠ V301), C296 (= C302), D451 (≠ N455), F453 (≠ G457), F459 (= F463)
3injA Human mitochondrial aldehyde dehydrogenase complexed with agonist alda-1 (see paper)
43% identity, 96% coverage: 20:493/495 of query aligns to 14:489/494 of 3injA
- active site: N163 (= N168), K186 (= K191), E262 (= E267), C296 (= C302), E393 (= E397), E470 (≠ D474)
- binding N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide: M118 (≠ G123), F164 (= F169), L167 (= L172), F286 (≠ A292), F290 (≠ Y296), D451 (≠ N455), F453 (≠ G457)
2vleA The structure of daidzin, a naturally occurring anti alcohol- addiction agent, in complex with human mitochondrial aldehyde dehydrogenase (see paper)
43% identity, 96% coverage: 20:493/495 of query aligns to 14:489/494 of 2vleA
- active site: N163 (= N168), K186 (= K191), E262 (= E267), C296 (= C302), E393 (= E397), E470 (≠ D474)
- binding daidzin: M118 (≠ G123), F164 (= F169), M168 (≠ L173), W171 (= W176), F286 (≠ A292), F290 (≠ Y296), C295 (≠ V301), C296 (= C302), D451 (≠ N455), V452 (≠ D456), F453 (≠ G457)
Query Sequence
>15420 b1300 gamma-Glu-gamma-aminobutyraldehyde dehydrogenase, NAD(P)H-dependent (NCBI)
MNFHHLAYWQDKALSLAIENRLFINGEYTAAAENETFETVDPVTQAPLAKIARGKSVDID
RAMSAARGVFERGDWSLSSPAKRKAVLNKLADLMEAHAEELALLETLDTGKPIRHSLRDD
IPGAARAIRWYAEAIDKVYGEVATTSSHELAMIVREPVGVIAAIVPWNFPLLLTCWKLGP
ALAAGNSVILKPSEKSPLSAIRLAGLAKEAGLPDGVLNVVTGFGHEAGQALSRHNDIDAI
AFTGSTRTGKQLLKDAGDSNMKRVWLEAGGKSANIVFADCPDLQQAASATAAGIFYNQGQ
VCIAGTRLLLEESIADEFLALLKQQAQNWQPGHPLDPATTMGTLIDCAHADSVHSFIREG
ESKGQLLLDGRNAGLAAAIGPTIFVDVDPNASLSREEIFGPVLVVTRFTSEEQALQLAND
SQYGLGAAVWTRDLSRAHRMSRRLKAGSVFVNNYNDGDMTVPFGGYKQSGNGRDKSLHAL
EKFTELKTIWISLEA
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory