SitesBLAST
Comparing 15814 FitnessBrowser__Keio:15814 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
5lnxD Crystal structure of mmgc, an acyl-coa dehydrogenase from bacillus subtilis.
35% identity, 89% coverage: 38:377/383 of query aligns to 34:373/374 of 5lnxD
- active site: L122 (= L124), T123 (= T125), G239 (≠ E241), E358 (≠ G362), K370 (≠ R374)
- binding flavin-adenine dinucleotide: L122 (= L124), T123 (= T125), G128 (= G130), S129 (= S131), F153 (= F155), T155 (= T157), R265 (= R267), Q267 (≠ A269), F268 (= F270), I272 (= I274), N275 (= N277), I278 (= I280), Q331 (= Q335), I332 (= I336), G335 (= G339), Y357 (≠ G361), T360 (= T364), E362 (= E366)
2pg0A Crystal structure of acyl-coa dehydrogenase from geobacillus kaustophilus
32% identity, 97% coverage: 5:376/383 of query aligns to 5:378/380 of 2pg0A
- active site: M124 (≠ L124), T125 (= T125), E243 (= E241), A364 (≠ G362), R376 (= R374)
- binding flavin-adenine dinucleotide: I122 (≠ L122), M124 (≠ L124), T125 (= T125), G130 (= G130), S131 (= S131), F155 (= F155), I156 (= I156), T157 (= T157), R269 (= R267), F272 (= F270), F279 (≠ N277), Q337 (= Q335), L338 (≠ I336), G340 (= G338), G341 (= G339), V359 (≠ C357), I362 (= I360), Y363 (≠ G361), T366 (= T364), E368 (= E366), M369 (≠ I367)
4iv6B X-ray crystal structure of an isovaleryl-coa dehydrogenase from mycobacterium smegmatis (see paper)
33% identity, 98% coverage: 4:377/383 of query aligns to 1:376/383 of 4iv6B
- active site: L121 (= L124), T122 (= T125), G240 (≠ E241), E361 (≠ G362), K373 (≠ R374)
- binding dihydroflavine-adenine dinucleotide: L121 (= L124), T122 (= T125), G126 (≠ A129), G127 (= G130), S128 (= S131), W152 (≠ F155), I153 (= I156), S154 (≠ T157), R266 (= R267), S268 (≠ A269), F269 (= F270), I273 (= I274), H276 (≠ N277), V279 (≠ I280), R334 (≠ Q335), V335 (≠ I336), G338 (= G339), L356 (≠ C357), G360 (= G361), T363 (= T364), E365 (= E366), I366 (= I367)
4l1fA Electron transferring flavoprotein of acidaminococcus fermentans: towards a mechanism of flavin-based electron bifurcation (see paper)
31% identity, 99% coverage: 1:379/383 of query aligns to 1:380/380 of 4l1fA
- active site: L125 (= L124), T126 (= T125), G242 (≠ E241), E363 (≠ G362), R375 (= R374)
- binding coenzyme a persulfide: T132 (≠ S131), H179 (≠ K178), F232 (= F231), M236 (= M235), E237 (≠ Y236), L239 (≠ F238), D240 (≠ E239), R243 (= R242), Y362 (≠ G361), E363 (≠ G362), G364 (= G363), R375 (= R374)
- binding flavin-adenine dinucleotide: F123 (≠ L122), L125 (= L124), T126 (= T125), G131 (= G130), T132 (≠ S131), F156 (= F155), I157 (= I156), T158 (= T157), R268 (= R267), Q270 (≠ A269), F271 (= F270), I275 (= I274), F278 (≠ N277), L281 (≠ I280), Q336 (= Q335), I337 (= I336), G340 (= G339), I358 (≠ C357), Y362 (≠ G361), T365 (= T364), Q367 (≠ E366)
- binding 1,3-propandiol: L5 (= L5), Q10 (≠ E10)
7y0bA Crystal structure of human short-chain acyl-coa dehydrogenase
31% identity, 99% coverage: 5:382/383 of query aligns to 7:385/385 of 7y0bA
- binding (2S,3R,4R,5S,6R)-2-[4-chloranyl-3-[[4-[(3S)-oxolan-3-yl]oxyphenyl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol: M343 (≠ L340), T347 (≠ D344), E348 (= E345)
- binding flavin-adenine dinucleotide: F125 (≠ L122), L127 (= L124), S128 (≠ T125), G133 (= G130), S134 (= S131), W158 (≠ F155), T160 (= T157), R270 (= R267), F273 (= F270), L280 (≠ N277), V282 (≠ M279), Q338 (= Q335), I339 (= I336), G342 (= G339), I360 (≠ C357), Y364 (≠ G361), T367 (= T364), E369 (= E366), I370 (= I367), L373 (≠ Y370)
8sgsA Short-chain specific acyl-CoA dehydrogenase, mitochondrial (see paper)
31% identity, 98% coverage: 5:381/383 of query aligns to 4:381/381 of 8sgsA
- binding coenzyme a: S131 (= S131), A133 (≠ N133), N177 (≠ K178), F231 (= F231), M235 (= M235), L238 (≠ F238), I312 (≠ R312), E362 (≠ G362), G363 (= G363)
- binding flavin-adenine dinucleotide: F122 (≠ L122), L124 (= L124), S125 (≠ T125), G130 (= G130), S131 (= S131), W155 (≠ F155), T157 (= T157), R267 (= R267), F270 (= F270), L274 (≠ I274), L277 (≠ N277), Q335 (= Q335), I336 (= I336), G338 (= G338), G339 (= G339), I357 (≠ C357), I360 (= I360), Y361 (≠ G361), T364 (= T364), E366 (= E366)
P16219 Short-chain specific acyl-CoA dehydrogenase, mitochondrial; SCAD; Butyryl-CoA dehydrogenase; EC 1.3.8.1 from Homo sapiens (Human) (see 3 papers)
31% identity, 99% coverage: 5:382/383 of query aligns to 34:412/412 of P16219
- G90 (= G62) to S: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs121908005
- E104 (= E76) natural variant: Missing (in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs387906308)
- 152:161 (vs. 122:131, 70% identical) binding in other chain
- R171 (≠ T141) to W: 69% of wild-type acyl-CoA dehydrogenase activity; confers susceptibility to ethylmalonicaciduria; dbSNP:rs1800556
- WIT 185:187 (≠ FIT 155:157) binding in other chain
- A192 (≠ Y162) to V: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs28940874
- G209 (≠ A180) to S: 86% of wild-type acyl-CoA dehydrogenase activity; confers susceptibility to ethylmalonicaciduria; dbSNP:rs1799958
- R297 (= R267) binding
- Q308 (= Q278) binding in other chain
- R325 (= R295) to W: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs121908006
- S353 (≠ A323) to L: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs28941773
- QILGG 365:369 (≠ QIMGG 335:339) binding
- R380 (= R350) to W: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs28940875
- TSE 394:396 (≠ TDE 364:366) binding in other chain
Sites not aligning to the query:
- 1:24 modified: transit peptide, Mitochondrion
7y0aC Crystal structure of human short-chain acyl-coa dehydrogenase
31% identity, 98% coverage: 5:381/383 of query aligns to 10:387/387 of 7y0aC
- binding flavin-adenine dinucleotide: F128 (≠ L122), L130 (= L124), S131 (≠ T125), G136 (= G130), S137 (= S131), W161 (≠ F155), T163 (= T157), T214 (= T208), R273 (= R267), F276 (= F270), L280 (≠ I274), L283 (≠ N277), V285 (≠ M279), Q341 (= Q335), I342 (= I336), G345 (= G339), I363 (≠ C357), Y367 (≠ G361), T370 (= T364), E372 (= E366), L376 (≠ Y370)
2dvlA Crystal structure of project tt0160 from thermus thermophilus hb8
35% identity, 98% coverage: 5:378/383 of query aligns to 1:370/370 of 2dvlA
- active site: L121 (= L124), T122 (= T125), G233 (≠ E241), E354 (≠ G362), R366 (= R374)
- binding flavin-adenine dinucleotide: L121 (= L124), T122 (= T125), G127 (= G130), S128 (= S131), W152 (≠ F155), I153 (= I156), T154 (= T157), T356 (= T364), E358 (= E366)
2vigB Crystal structure of human short-chain acyl coa dehydrogenase
30% identity, 98% coverage: 5:381/383 of query aligns to 1:371/371 of 2vigB
- active site: L121 (= L124), S122 (≠ T125), G231 (≠ E241), E352 (≠ G362), G364 (≠ R374)
- binding coenzyme a persulfide: S128 (= S131), F221 (= F231), M225 (= M235), Q226 (≠ Y236), L228 (≠ F238), D229 (≠ E239), R232 (= R242), E352 (≠ G362), G353 (= G363), I357 (= I367)
- binding flavin-adenine dinucleotide: L121 (= L124), S122 (≠ T125), G127 (= G130), S128 (= S131), W152 (≠ F155), T154 (= T157), R257 (= R267), F260 (= F270), L264 (≠ I274), L267 (≠ N277), Q325 (= Q335), I326 (= I336), G329 (= G339), I347 (≠ C357), Y351 (≠ G361), T354 (= T364), E356 (= E366)
4n5fA Crystal structure of a putative acyl-coa dehydrogenase with bound fadh2 from burkholderia cenocepacia j2315
32% identity, 98% coverage: 1:376/383 of query aligns to 2:378/378 of 4n5fA
- active site: L126 (= L124), T127 (= T125), G243 (≠ E241), E364 (≠ G362), R376 (= R374)
- binding dihydroflavine-adenine dinucleotide: L126 (= L124), T127 (= T125), G132 (= G130), S133 (= S131), F157 (= F155), T159 (= T157), T210 (= T208), Y363 (≠ G361), T366 (= T364), E368 (= E366), M372 (≠ Y370)
P15651 Short-chain specific acyl-CoA dehydrogenase, mitochondrial; SCAD; Butyryl-CoA dehydrogenase; EC 1.3.8.1 from Rattus norvegicus (Rat) (see 2 papers)
30% identity, 91% coverage: 33:382/383 of query aligns to 61:412/412 of P15651
Sites not aligning to the query:
- 1:24 modified: transit peptide, Mitochondrion
1jqiA Crystal structure of rat short chain acyl-coa dehydrogenase complexed with acetoacetyl-coa (see paper)
30% identity, 91% coverage: 33:381/383 of query aligns to 34:384/384 of 1jqiA
- active site: G377 (≠ R374)
- binding acetoacetyl-coenzyme a: L95 (≠ Q91), F125 (≠ L122), S134 (= S131), F234 (= F231), M238 (= M235), Q239 (≠ Y236), L241 (≠ F238), D242 (≠ E239), R245 (= R242), Y364 (≠ G361), E365 (≠ G362), G366 (= G363)
- binding flavin-adenine dinucleotide: F125 (≠ L122), L127 (= L124), S128 (≠ T125), G133 (= G130), S134 (= S131), W158 (≠ F155), T160 (= T157), R270 (= R267), F273 (= F270), L280 (≠ N277), Q338 (= Q335), I339 (= I336), G342 (= G339), I360 (≠ C357), T367 (= T364), E369 (= E366), I370 (= I367)
5ol2F The electron transferring flavoprotein/butyryl-coa dehydrogenase complex from clostridium difficile (see paper)
30% identity, 91% coverage: 32:378/383 of query aligns to 30:378/378 of 5ol2F
- active site: L124 (= L124), T125 (= T125), G241 (≠ E241), G374 (≠ R374)
- binding calcium ion: E33 (≠ N35), R35 (≠ T37)
- binding coenzyme a persulfide: L238 (≠ F238), R242 (= R242), E362 (≠ G362), G363 (= G363)
- binding flavin-adenine dinucleotide: F122 (≠ L122), L124 (= L124), T125 (= T125), P127 (= P127), T131 (≠ S131), F155 (= F155), I156 (= I156), T157 (= T157), E198 (≠ L198), R267 (= R267), F270 (= F270), L274 (≠ I274), F277 (≠ N277), Q335 (= Q335), L336 (≠ I336), G338 (= G338), G339 (= G339), Y361 (≠ G361), T364 (= T364), E366 (= E366)
Sites not aligning to the query:
1bucA Three-dimensional structure of butyryl-coa dehydrogenase from megasphaera elsdenii (see paper)
32% identity, 99% coverage: 1:378/383 of query aligns to 1:383/383 of 1bucA
- active site: L128 (= L124), T129 (= T125), G246 (≠ E241), E367 (≠ G362), G379 (≠ R374)
- binding acetoacetyl-coenzyme a: L96 (≠ Q91), F126 (≠ L122), G134 (= G130), T135 (≠ S131), T162 (= T157), N182 (≠ K178), H183 (≠ K179), F236 (= F231), M240 (= M235), M241 (≠ Y236), L243 (≠ F238), D244 (≠ E239), T317 (≠ R312), Y366 (≠ G361), E367 (≠ G362), G368 (= G363)
- binding flavin-adenine dinucleotide: F126 (≠ L122), L128 (= L124), T129 (= T125), G134 (= G130), T135 (≠ S131), F160 (= F155), T162 (= T157), Y366 (≠ G361), T369 (= T364), E371 (= E366), M375 (≠ Y370)
Q06319 Acyl-CoA dehydrogenase, short-chain specific; Butyryl-CoA dehydrogenase; BCAD; SCAD; EC 1.3.8.1 from Megasphaera elsdenii (see paper)
32% identity, 99% coverage: 1:378/383 of query aligns to 1:383/383 of Q06319
- E367 (≠ G362) active site, Proton acceptor; mutation to Q: Loss of activity.
1ukwB Crystal structure of medium-chain acyl-coa dehydrogenase from thermus thermophilus hb8
33% identity, 98% coverage: 1:377/383 of query aligns to 1:377/379 of 1ukwB
- active site: L124 (= L124), S125 (≠ T125), T241 (≠ E241), E362 (≠ G362), R374 (= R374)
- binding cobalt (ii) ion: D145 (≠ G145), H146 (≠ K146)
- binding flavin-adenine dinucleotide: F122 (≠ L122), L124 (= L124), S125 (≠ T125), G130 (= G130), S131 (= S131), W155 (≠ F155), S157 (≠ T157), K200 (= K200), L357 (≠ C357), Y361 (≠ G361), E362 (≠ G362), T364 (= T364), E366 (= E366), L370 (≠ Y370)
1ukwA Crystal structure of medium-chain acyl-coa dehydrogenase from thermus thermophilus hb8
33% identity, 98% coverage: 1:377/383 of query aligns to 1:377/379 of 1ukwA
- active site: L124 (= L124), S125 (≠ T125), T241 (≠ E241), E362 (≠ G362), R374 (= R374)
- binding flavin-adenine dinucleotide: F122 (≠ L122), L124 (= L124), S125 (≠ T125), G130 (= G130), S131 (= S131), W155 (≠ F155), S157 (≠ T157), L357 (≠ C357), Y361 (≠ G361), E362 (≠ G362), T364 (= T364), E366 (= E366), L370 (≠ Y370)
7p9aA Structure of cyclohex-1-ene-1-carboxyl-coa dehydrogenase complexed with cyclohex-1,5-diene-1-carboxyl-coa (see paper)
34% identity, 97% coverage: 5:377/383 of query aligns to 4:378/380 of 7p9aA
- binding 1,5 Dienoyl-CoA: S131 (= S131), L133 (≠ N133), K178 (= K179), F231 (= F231), M235 (= M235), L238 (≠ F238), N241 (≠ E241), R242 (= R242), Y362 (≠ G361), T363 (≠ G362), G364 (= G363), R375 (= R374)
- binding flavin-adenine dinucleotide: L122 (= L122), A124 (≠ L124), T125 (= T125), G130 (= G130), S131 (= S131), F155 (= F155), I156 (= I156), T157 (= T157), K200 (= K200), N208 (≠ T208), L358 (≠ C357), T365 (= T364), Q367 (≠ E366), I368 (= I367)
7p9xA Structure of cyclohex-1-ene-1-carboxyl-coa dehydrogenase complexed with cyclohex-1-ene-1-carboxyl-coa (see paper)
34% identity, 97% coverage: 5:377/383 of query aligns to 2:376/378 of 7p9xA
- binding 1-monoenoyl-CoA: L82 (≠ F85), D89 (≠ N89), S129 (= S131), L131 (≠ N133), K176 (= K179), F229 (= F231), M233 (= M235), L236 (≠ F238), R240 (= R242), Y360 (≠ G361), T361 (≠ G362), G362 (= G363), R373 (= R374)
- binding flavin-adenine dinucleotide: A122 (≠ L124), T123 (= T125), G128 (= G130), S129 (= S131), F153 (= F155), I154 (= I156), T155 (= T157), N206 (≠ T208), L356 (≠ C357), Y360 (≠ G361), T363 (= T364), Q365 (≠ E366), I366 (= I367)
Query Sequence
>15814 FitnessBrowser__Keio:15814
MDFSLTEEQELLLASIRELITTNFPEEYFRTCDQNGTYPREFMRALADNGISMLGVPEEF
GGIPADYVTQMLALMEVSKCGAPAFLITNGQCIHSMRRFGSAEQLRKTAESTLETGDPAY
ALALTEPGAGSDNNSATTTYTRKNGKVYINGQKTFITGAKEYPYMLVLARDPQPKDPKKA
FTLWWVDSSKPGIKINPLHKIGWHMLSTCEVYLDNVEVEESDMVGEEGMGFLNVMYNFEM
ERLINAARSTGFAECAFEDAARYANQRIAFGKPIGHNQMIQEKLALMAIKIDNMRNMVLK
VAWQADQHQSLRTSAALAKLYCARTAMEVIDDAIQIMGGLGYTDEARVSRFWRDVRCERI
GGGTDEIMIYVAGRQILKDYQNK
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory