SitesBLAST
Comparing 15864 FitnessBrowser__Keio:15864 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
5u0mA Fatty aldehyde dehydrogenase from marinobacter aquaeolei vt8 and cofactor complex (see paper)
60% identity, 99% coverage: 2:486/492 of query aligns to 5:488/488 of 5u0mA
- active site: N148 (= N145), K171 (= K168), E246 (= E243), C280 (= C277), E377 (= E375), P455 (= P453)
- binding nicotinamide-adenine-dinucleotide: F144 (= F141), Y147 (= Y144), N148 (= N145), K171 (= K168), S173 (= S170), E174 (= E171), G207 (= G204), T222 (= T219), G223 (= G220), S224 (= S221), V227 (≠ T224), E246 (= E243), M247 (= M244), G248 (= G245), C280 (= C277), E377 (= E375), F379 (= F377)
5u0lA X-ray crystal structure of fatty aldehyde dehydrogenase enzymes from marinobacter aquaeolei vt8 complexed with a substrate (see paper)
60% identity, 99% coverage: 2:486/492 of query aligns to 5:488/488 of 5u0lA
- active site: N148 (= N145), K171 (= K168), E246 (= E243), C280 (= C277), E377 (= E375), P455 (= P453)
- binding decanal: K107 (= K104), H152 (= H149), L153 (= L150), G156 (= G153), H157 (= H154), S456 (= S454), A457 (= A455)
3ju8A Crystal structure of succinylglutamic semialdehyde dehydrogenase from pseudomonas aeruginosa.
63% identity, 98% coverage: 2:484/492 of query aligns to 4:486/486 of 3ju8A
- active site: N147 (= N145), K170 (= K168), E245 (= E243), C279 (= C277), E377 (= E375), P455 (= P453)
- binding nicotinamide-adenine-dinucleotide: G144 (= G142), Y146 (= Y144), N147 (= N145), L152 (= L150), K170 (= K168), S172 (= S170), F220 (= F218), T221 (= T219), G222 (= G220), S223 (= S221), T226 (= T224), E245 (= E243), M246 (= M244), G247 (= G245), C279 (= C277), E377 (= E375), F379 (= F377), F444 (= F442)
6fkuA Structure and function of aldehyde dehydrogenase from thermus thermophilus: an enzyme with an evolutionarily-distinct c-terminal arm (recombinant protein with shortened c-terminal, in complex with NADP) (see paper)
33% identity, 91% coverage: 19:464/492 of query aligns to 31:495/511 of 6fkuA
- active site: N159 (= N145), E261 (= E243), C295 (= C277), E483 (≠ R452)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: I155 (≠ F141), T156 (≠ G142), N159 (= N145), K182 (= K168), S184 (= S170), E185 (= E171), G214 (= G200), G215 (≠ R201), K216 (≠ E202), G220 (= G204), Q221 (= Q205), F237 (= F218), T238 (= T219), G239 (= G220), S240 (= S221), V243 (≠ T224), E261 (= E243), L262 (≠ M244), C295 (= C277), R342 (≠ Q325), F343 (≠ A326), E404 (= E375), F406 (= F377)
5izdA Wild-type glyceraldehyde dehydrogenase from thermoplasma acidophilum in complex with NADP
31% identity, 83% coverage: 3:411/492 of query aligns to 5:417/494 of 5izdA
- active site: N149 (= N145), K172 (= K168), E247 (= E243), C281 (= C277), E381 (= E375)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: L145 (≠ F141), T146 (≠ G142), W148 (≠ Y144), K172 (= K168), P173 (= P169), S174 (= S170), S175 (≠ E171), R204 (vs. gap), G205 (= G200), G209 (= G204), D210 (≠ Q205), G225 (= G220), S226 (= S221), T229 (= T224)
Sites not aligning to the query:
4pz2B Structure of zm aldh2-6 (rf2f) in complex with NAD (see paper)
32% identity, 93% coverage: 3:460/492 of query aligns to 13:476/494 of 4pz2B
- active site: N159 (= N145), K182 (= K168), E258 (= E243), C292 (= C277), E392 (= E375), D469 (≠ P453)
- binding nicotinamide-adenine-dinucleotide: I155 (≠ F141), I156 (≠ G142), P157 (= P143), W158 (≠ Y144), N159 (= N145), M164 (≠ L150), K182 (= K168), A184 (≠ S170), E185 (= E171), G215 (= G200), G219 (= G204), F233 (= F218), T234 (= T219), G235 (= G220), S236 (= S221), V239 (≠ T224), E258 (= E243), L259 (≠ M244), C292 (= C277), E392 (= E375), F394 (= F377)
Q9H2A2 2-aminomuconic semialdehyde dehydrogenase; Aldehyde dehydrogenase 12; Aldehyde dehydrogenase family 8 member A1; EC 1.2.1.32 from Homo sapiens (Human) (see paper)
31% identity, 90% coverage: 21:461/492 of query aligns to 29:476/487 of Q9H2A2
- R109 (≠ A100) mutation to A: About 65-fold loss of catalytic efficiency.
- N155 (= N145) mutation to A: Complete loss of activity.
- R451 (≠ A436) mutation to A: Complete loss of activity.
3jz4A Crystal structure of e. Coli NADP dependent enzyme (see paper)
32% identity, 93% coverage: 5:461/492 of query aligns to 14:471/481 of 3jz4A
- active site: N156 (= N145), K179 (= K168), E254 (= E243), C288 (= C277), E385 (= E375), E462 (≠ P453)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: P154 (= P143), W155 (≠ Y144), K179 (= K168), A181 (≠ S170), S182 (≠ E171), A212 (≠ R201), G216 (= G204), G232 (= G220), S233 (= S221), I236 (≠ T224), C288 (= C277), K338 (≠ Q329), E385 (= E375), F387 (= F377)
P25526 Succinate-semialdehyde dehydrogenase [NADP(+)] GabD; SSDH; Glutarate-semialdehyde dehydrogenase; EC 1.2.1.79; EC 1.2.1.- from Escherichia coli (strain K12) (see paper)
32% identity, 93% coverage: 5:461/492 of query aligns to 15:472/482 of P25526
Q9HTJ1 NAD/NADP-dependent betaine aldehyde dehydrogenase; BADH; EC 1.2.1.8 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 2 papers)
30% identity, 91% coverage: 3:452/492 of query aligns to 9:463/490 of Q9HTJ1
- GAWN 150:153 (≠ GPYN 142:145) binding
- K162 (≠ H154) active site, Charge relay system
- KPSE 176:179 (= KPSE 168:171) binding
- G209 (= G200) binding
- GTST 230:233 (≠ SANT 221:224) binding
- E252 (= E243) active site, Proton acceptor
- C286 (= C277) binding covalent; modified: Cysteine sulfenic acid (-SOH)
- E387 (= E375) binding
Sites not aligning to the query:
- 464 active site, Charge relay system
4cazA Crystal structure of betaine aldehyde dehydrogenase from pseudomonas aeruginosa in complex with nadh
30% identity, 91% coverage: 3:452/492 of query aligns to 8:462/489 of 4cazA
- active site: N152 (= N145), K175 (= K168), E251 (= E243), C285 (= C277), E386 (= E375)
- binding [[(2R,3S,4R,5R)-5-[(3R)-3-aminocarbonyl-3,4-dihydro-2H-pyridin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanidyl-phosphoryl] [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl phosphate: I148 (≠ F141), G149 (= G142), W151 (≠ Y144), N152 (= N145), K175 (= K168), E178 (= E171), G208 (= G200), G212 (= G204), F226 (= F218), T227 (= T219), G228 (= G220), G229 (≠ S221), T232 (= T224), V236 (≠ L228), E251 (= E243), L252 (≠ M244), C285 (= C277), E386 (= E375), F388 (= F377)
Sites not aligning to the query:
2woxA Betaine aldehyde dehydrogenase from pseudomonas aeruginosa with NAD(p) h-catalytic thiol adduct. (see paper)
30% identity, 91% coverage: 3:452/492 of query aligns to 8:462/489 of 2woxA
- active site: N152 (= N145), K175 (= K168), E251 (= E243), C285 (= C277), E386 (= E375)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: I148 (≠ F141), G149 (= G142), W151 (≠ Y144), N152 (= N145), K175 (= K168), S177 (= S170), E178 (= E171), G208 (= G200), G212 (= G204), F226 (= F218), T227 (= T219), G228 (= G220), G229 (≠ S221), T232 (= T224), V236 (≠ L228), E251 (= E243), L252 (≠ M244), C285 (= C277), E386 (= E375), F388 (= F377)
Sites not aligning to the query:
2wmeA Crystallographic structure of betaine aldehyde dehydrogenase from pseudomonas aeruginosa (see paper)
30% identity, 91% coverage: 3:452/492 of query aligns to 8:462/489 of 2wmeA
- active site: N152 (= N145), K175 (= K168), E251 (= E243), C285 (= C277), E386 (= E375)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G149 (= G142), W151 (≠ Y144), K175 (= K168), S177 (= S170), E178 (= E171), G208 (= G200), G212 (= G204), F226 (= F218), G228 (= G220), G229 (≠ S221), T232 (= T224), V236 (≠ L228)
Sites not aligning to the query:
5iuwA Crystal structure of indole-3-acetaldehyde dehydrogenase in complexed with NAD+ and iaa (see paper)
32% identity, 89% coverage: 21:460/492 of query aligns to 39:483/495 of 5iuwA
- active site: N166 (= N145), K189 (= K168), E265 (= E243), C300 (= C277), E399 (= E375), D476 (≠ P453)
- binding 1h-indol-3-ylacetic acid: F167 (= F146), M170 (≠ H149), C300 (= C277), D457 (≠ T434), F465 (= F442)
- binding nicotinamide-adenine-dinucleotide: I162 (≠ F141), V163 (≠ G142), P164 (= P143), W165 (≠ Y144), N166 (= N145), K189 (= K168), G222 (= G200), G226 (= G204), K227 (≠ Q205), F240 (= F218), T241 (= T219), G242 (= G220), S243 (= S221), I246 (≠ T224), Y253 (≠ Q231), E265 (= E243), A266 (≠ M244), C300 (= C277), E399 (= E375), F401 (= F377)
5iuvA Crystal structure of indole-3-acetaldehyde dehydrogenase in complexed with NAD+ (see paper)
32% identity, 89% coverage: 21:460/492 of query aligns to 39:483/495 of 5iuvA
- active site: N166 (= N145), K189 (= K168), E265 (= E243), C300 (= C277), E399 (= E375), D476 (≠ P453)
- binding nicotinamide-adenine-dinucleotide: I162 (≠ F141), V163 (≠ G142), P164 (= P143), W165 (≠ Y144), N166 (= N145), K189 (= K168), S191 (= S170), G222 (= G200), G226 (= G204), K227 (≠ Q205), F240 (= F218), T241 (= T219), G242 (= G220), S243 (= S221), I246 (≠ T224), Y253 (≠ Q231), E265 (= E243), A266 (≠ M244), C300 (= C277), E399 (= E375), F401 (= F377)
7jsoA P. Syringae alda indole-3-acetaldehyde dehydrogenase c302a mutant in complex with NAD+ and iaa (see paper)
31% identity, 89% coverage: 21:460/492 of query aligns to 39:483/495 of 7jsoA
- active site: N166 (= N145), E265 (= E243), A300 (≠ C277), D476 (≠ P453)
- binding 1h-indol-3-ylacetic acid: F167 (= F146), W174 (≠ G153), V299 (≠ R276), A300 (≠ C277), T301 (= T278), D457 (≠ T434), F465 (= F442)
- binding 1,4-dihydronicotinamide adenine dinucleotide: I162 (≠ F141), V163 (≠ G142), P164 (= P143), W165 (≠ Y144), K189 (= K168), E192 (= E171), G222 (= G200), G226 (= G204), K227 (≠ Q205), F240 (= F218), G242 (= G220), S243 (= S221), I246 (≠ T224), A266 (≠ M244), G267 (= G245), A300 (≠ C277), E399 (= E375), F401 (= F377)
8vr1A Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (ctp bound)
29% identity, 91% coverage: 3:452/492 of query aligns to 7:461/488 of 8vr1A
8vr0A Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (gmp bound)
29% identity, 91% coverage: 3:452/492 of query aligns to 7:461/488 of 8vr0A
8vqzA Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (cmp bound)
29% identity, 91% coverage: 3:452/492 of query aligns to 7:461/488 of 8vqzA
8vqwC Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (coa bound)
29% identity, 91% coverage: 3:452/492 of query aligns to 7:461/488 of 8vqwC
- binding coenzyme a: I147 (≠ F141), W150 (≠ Y144), K174 (= K168), S176 (= S170), E177 (= E171), G207 (= G200), G211 (= G204), F225 (= F218), G227 (= G220), G228 (≠ S221), S231 (≠ T224), H331 (≠ A326), F387 (= F377)
Query Sequence
>15864 FitnessBrowser__Keio:15864
MTLWINGDWITGQGASRVKRNPVSGEVLWQGNDADAAQVEQACRAARAAFPRWARLSFAE
RHAVVERFAALLESNKAELTAIIARETGKPRWEAATEVTAMINKIAISIKAYHVRTGEQR
SEMPDGAASLRHRPHGVLAVFGPYNFPGHLPNGHIVPALLAGNTIIFKPSELTPWSGEAV
MRLWQQAGLPPGVLNLVQGGRETGQALSALEDLDGLLFTGSANTGYQLHRQLSGQPEKIL
ALEMGGNNPLIIDEVADIDAAVHLTIQSAFVTAGQRCTCARRLLLKSGAQGDAFLARLVA
VSQRLTPGNWDDEPQPFIGGLISEQAAQQVVTAWQQLEAMGGRPLLAPRLLQAGTSLLTP
GIIEMTGVAGVPDEEVFGPLLRVWRYDTFDEAIRMANNTRFGLSCGLVSPEREKFDQLLL
EARAGIVNWNKPLTGAASTAPFGGIGASGNHRPSAWYAADYCAWPMASLESDSLTLPATL
NPGLDFSDEVVR
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory