SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing 16127 b2019 ATP phosphoribosyltransferase (NCBI) to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

1q1kA Structure of atp-phosphoribosyltransferase from e. Coli complexed with pr-atp (see paper)
98% identity, 99% coverage: 5:299/299 of query aligns to 1:288/288 of 1q1kA

query
sites
1q1kA

T

T

R

R

L

L

R

R

I

I

A

A

M

M

Q

Q

K

K

S

S

G

G

R
|
R

L

L

S

S

D

D

D

D

S

S

R

R

E

E

L

L

L

L

A

A

R

R

C

C

G

G

I

I

K

K

I

I

N

N

L

L

H

H

T

T

Q

Q

R

R

L

L

I

I

A

A

M

M

A

A

E

E

N

N

M

M

P

P

I

I

D

D

I

I

L

L

R

R

V

V

R
|
R

D
|
D

D
|
D

D

D

I

I

P

P

G

G

L

L

V

V

M

M

D

D

G

G

V

V

V

V

D

D

L

L

G

G

I

I

I

I

G

G

E

E

N
|
N

V
|
V

L

L

E

E

E

E

E

E

L

L

L

L

N

N

R

R

R

R

A

A

Q

Q

G

G

E

E

D

D

P

P

R

R

Y

Y

F

F

T

T

L

L

R

R

R

R

L

L

D

D

F

F

G

G

G

G

C
|
C

R

R

L

L

S

S

L

L

A

A

T

T

P

P

V

V

D

D

E

E

A

A

W

W

D

D

G

G

P

P

L

L

S

S

L

L

N

N

G

G

K

K

R

R

I

I

A

A

T

T

S

S

Y
|
Y

P

P

H

H

L

L

L

L

K

K

R

R

Y

Y

L

L

D

D

Q

Q

K

K

G

G

I

I

S

S

F

F

K

K

S

S

C

C

L

L

L

L

N

N

G

G

S

S

V

V

E
|
E

V

V

A

A

P

P

R

R

A

A

G

G

L

L

A

A

D

D

A

A

I

I

C

C

D
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D

L
|
L

V
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V

S
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S

T
|
T

G
|
G

A
|
A

T
|
T

L

L

E

E

A

A

N

N

G

G

L

L

R

R

E

E

V

V

E

E

V

V

I

I

Y

Y

R

R

S

S

K

K

A

A

C

C

L

L

I

I

Q

Q

R

R

D

D

G

G

E

E

M

M

E

E

E

E

S

S

K

K

Q

Q

Q

Q

L

L

I

I

D

D

K

K

L

L

L

L

T

T

R

R

I

I

Q

Q

G

G

V

V

I

I

Q

Q

A

A

R

R

E

E

S

S

K

K

Y

Y

I

I

M

M

M

M

H

H

A

A

P

P

T

T

E

E

R

R

L

L

D

D

E

E

V

V

I

I

A

A

L

L

L

L

P

P

G

G

A

A

E

E

R

R

P

P

T

T

I

I

L

L

P

P

L

L

A

-

G

-

D

-

Q

-

Q

-

R

-

V

-

A

A

M

M

H

H

M

M

V

V

S

S

S

S

E

E

T

T

L

L

F

F

W

W

E

E

T

T

M

M

E

E

K

K

L

L

K

K

A

A

L

L

G

G

A

A

S

S

S

S

I

I

L

L

V

V

L

L

P

P

I

I

E

E

K

K

M

M

M

M

E

E

binding phosphoribosyl atp : R12 (= R16), R50 (= R54), D51 (= D55), D52 (= D56), N71 (= N75), V72 (= V76), C100 (= C104), Y127 (= Y131), E152 (= E156), D165 (= D169), L166 (= L170), V167 (= V171), S168 (= S172), T169 (= T173), G170 (= G174), A171 (= A175), T172 (= T176)

1h3dA Structure of the e.Coli atp-phosphoribosyltransferase (see paper)
98% identity, 99% coverage: 5:299/299 of query aligns to 1:288/288 of 1h3dA

query
sites
1h3dA

T

T

R

R

L

L

R

R

I

I

A

A

M

M

Q

Q

K

K

S

S

G

G

R
|
R

L

L

S

S

D

D

D

D

S

S

R

R

E

E

L

L

L

L

A

A

R

R

C

C

G

G

I

I

K

K

I

I

N

N

L

L

H

H

T

T

Q

Q

R

R

L

L

I

I

A

A

M

M

A

A

E

E

N

N

M

M

P

P

I

I

D

D

I

I

L

L

R

R

V

V

R

R

D

D

D

D

D

D

I

I

P

P

G

G

L

L

V

V

M

M

D

D

G

G

V

V

V

V

D

D

L

L

G

G

I

I

I

I

G

G

E

E

N

N

V

V

L

L

E

E

E

E

E

E

L

L

L

L

N

N

R

R

R

R

A

A

Q

Q

G

G

E

E

D

D

P

P

R

R

Y

Y

F

F

T

T

L

L

R

R

R

R

L

L

D

D

F

F

G

G

G

G

C
|
C

R

R

L

L

S

S

L

L

A

A

T

T

P

P

V

V

D

D

E

E

A

A

W

W

D

D

G

G

P

P

L

L

S

S

L

L

N

N

G

G

K

K

R

R

I

I

A

A

T

T

S

S

Y

Y

P

P

H

H

L

L

L

L

K

K

R

R

Y

Y

L

L

D

D

Q

Q

K

K

G

G

I

I

S

S

F

F

K

K

S

S

C

C

L

L

L

L

N

N

G

G

S

S

V

V

E
|
E

V

V

A

A

P

P

R

R

A

A

G

G

L

L

A

A

D

D

A

A

I

I

C

C

D
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D

L
|
L

V
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V

S
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S

T
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T

G
|
G

A
|
A

T
|
T

L

L

E

E

A

A

N

N

G

G

L

L

R

R

E

E

V

V

E

E

V

V

I

I

Y

Y

R

R

S

S

K

K

A

A

C

C

L

L

I

I

Q

Q

R

R

D

D

G

G

E

E

M

M

E

E

E

E

S

S

K

K

Q

Q

Q

Q

L

L

I

I

D

D

K

K

L

L

L

L

T

T

R

R

I

I

Q

Q

G

G

V

V

I

I

Q

Q

A

A

R

R

E

E

S

S

K

K

Y

Y

I

I

M

M

M

M

H

H

A

A

P

P

T

T

E

E

R

R

L

L

D

D

E

E

V

V

I

I

A

A

L

L

L

L

P

P

G

G

A

A

E

E

R

R

P

P

T

T

I

I

L

L

P

P

L

L

A

-

G

-

D

-

Q

-

Q

-

R

-

V

-

A

A

M

M

H

H

M

M

V

V

S

S

S

S

E

E

T

T

L

L

F

F

W

W

E

E

T

T

M

M

E

E

K

K

L

L

K

K

A

A

L

L

G

G

A

A

S

S

S

S

I

I

L

L

V

V

L

L

P

P

I

I

E

E

K

K

M

M

M

M

E

E

binding adenosine monophosphate: R12 (= R16), C100 (= C104), E152 (= E156), D165 (= D169), L166 (= L170), V167 (= V171), S168 (= S172), T169 (= T173), G170 (= G174), A171 (= A175), T172 (= T176)

4yb7A Adenosine triphosphate phosphoribosyltransferase from campylobacter jejuni in complex with atp (see paper)
67% identity, 99% coverage: 4:299/299 of query aligns to 1:296/296 of 4yb7A

query
sites
4yb7A

N

N

T

T

R

R

L

L

R

R

I

I

A

A

M

I

Q
|
Q

K

K

S

S

G
|
G

R
|
R

L
|
L

S

S

D

K

D

E

S

S

R

I

E

E

L

L

L

L

A

S

R

E

C

C

G

G

I

V

K

K

I

M

N

H

L

I

H

H

T

E

Q

Q

R

S

L

L

I

I

A

A

M

F

A

S

E

T

N

N

M

L

P

P

I

I

D

D

I

I

L

L

R

R

V

V

R
|
R

D
|
D

D
|
D

D

D

I

I

P

P

G

G

L

L

V

I

M

F

D

D

G

G

V

V

V

V

D

D

L

L

G

G

I

I

I

I

G

G

E

E

N
|
N

V

V

L

L

E

E

E

E

E

N

L

E

L

L

N

E

R

R

R

Q

A

S

Q

L

G

G

E

E

D

N

P

P

R

S

Y

Y

F

K

T

L

L

L

R

K

R

K

L

L

D

D

F

F

G
|
G

G
x
Y

C
|
C

R

R

L

L

S

S

L

L

A

A

T

L

P

P

V

Q

D

E

E

N

A

K

W

F

D

Q

G

N

P

L

L

K

S

D

L

F

N

E

G

G

K

L

R

R

I

I

A

A

T

T

S

S

Y

Y

P

P

H

Q

L

L

L

L

K

K

R

R

Y

F

L

M

D

K

Q

E

K

N

G

G

I

I

S

N

F

Y

K

K

S

N

C

C

L

T

L

L

N

T

G

G

S

S

V

V

E

E

V

V

A

A

P

P

R

R

A

A

G

N

L

L

A

A

D

D

A

A

I

I

C

C

D

D

L
|
L

V

V

S
|
S

T

S

G

G

A

A

T

T

L

L

E

Q

A

A

N

N

G

N

L

L

R

K

E

E

V

V

E

K

V

V

I

I

Y

Y

R

E

S

S

K

R

A

A

C

C

L

L

I

I

Q

Q

R

K

D

E

G

N

E

A

M

L

E

S

E

K

S

E

K

K

Q

Q

Q

A

L

L

I

V

D

D

K

K

L

I

L

M

T

L

R

R

I

V

Q

A

G

G

V

V

I

M

Q

Q

A

A

R

R

E

E

S

S

K

K

Y

Y

I

I

M

M

M

L

H

H

A

A

P

P

T

K

E

E

R

K

L

L

D

D

E

K

V

I

I

Q

A

A

L

L

L

L

P

P

G

G

A

V

E

E

R

R

P

P

T

T

I

I

L

L

P

P

L

L

A

A

G

H

D

D

Q

E

Q

K

R

N

V

V

A

A

M

L

H

H

M

M

V

V

S

S

S

K

E

E

T

N

L

L

F

F

W

W

E

E

T

T

M

M

E

E

K

A

L

L

K

K

A

E

L

E

G

G

A

A

S

S

S

S

I

I

L

L

V

V

L

L

P

P

I

I

E

E

K

K

M

M

M

L

E

K

binding adenosine-5'-triphosphate: Q9 (= Q12), G12 (= G15), R13 (= R16), L14 (= L17), R51 (= R54), D52 (= D55), D53 (= D56), N72 (= N75), G99 (= G102), Y100 (≠ G103), C101 (= C104), L167 (= L170), S169 (= S172)
binding magnesium ion: D52 (= D55), D53 (= D56)

4yb6A Adenosine triphosphate phosphoribosyltransferase from campylobacter jejuni in complex with the inhibitors amp and histidine (see paper)
67% identity, 99% coverage: 4:299/299 of query aligns to 1:296/296 of 4yb6A

query
sites
4yb6A

N

N

T

T

R

R

L

L

R

R

I

I

A

A

M

I

Q

Q

K

K

S

S

G

G

R

R

L

L

S

S

D

K

D

E

S

S

R

I

E

E

L

L

L

L

A

S

R

E

C

C

G

G

I

V

K

K

I

M

N

H

L

I

H

H

T

E

Q

Q

R

S

L

L

I

I

A

A

M

F

A

S

E

T

N

N

M

L

P

P

I

I

D

D

I

I

L

L

R

R

V

V

R

R

D

D

D

D

D

D

I

I

P

P

G

G

L

L

V

I

M

F

D

D

G

G

V

V

V

V

D

D

L

L

G

G

I

I

I

I

G

G

E

E

N

N

V

V

L

L

E

E

E

E

E

N

L

E

L

L

N

E

R

R

R

Q

A

S

Q

L

G

G

E

E

D

N

P

P

R

S

Y

Y

F

K

T

L

L

L

R

K

R

K

L

L

D

D

F

F

G

G

G

Y

C
|
C

R

R

L

L

S

S

L

L

A

A

T

L

P

P

V

Q

D

E

E

N

A

K

W

F

D

Q

G

N

P

L

L

K

S

D

L

F

N

E

G

G

K

L

R

R

I

I

A

A

T

T

S

S

Y

Y

P

P

H

Q

L

L

L

L

K

K

R

R

Y

F

L

M

D

K

Q

E

K

N

G

G

I

I

S

N

F

Y

K

K

S

N

C

C

L

T

L

L

N

T

G

G

S

S

V

V

E

E

V

V

A

A

P

P

R

R

A

A

G

N

L

L

A

A

D

D

A

A

I

I

C

C

D
|
D

L
|
L

V
|
V

S
|
S

T
x
S

G
|
G

A
|
A

T
|
T

L

L

E

Q

A

A

N

N

G

N

L

L

R

K

E

E

V

V

E

K

V

V

I

I

Y

Y

R

E

S

S

K

R

A

A

C

C

L

L

I

I

Q

Q

R

K

D

E

G

N

E

A

M

L

E

S

E

K

S

E

K

K

Q

Q

Q

A

L

L

I

V

D

D

K

K

L

I

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T

L

R

R

I

V

Q

A

G

G

V

V

I

M

Q

Q

A

A

R

R

E

E

S

S

K

K

Y
|
Y

I

I

M
|
M

M
x
L

H
|
H

A

A

P

P

T

K

E

E

R

K

L

L

D

D

E

K

V

I

I

Q

A

A

L

L

L

L

P

P

G
|
G

A
x
V

E
|
E

R
|
R

P
|
P

T
|
T

I

I

L

L

P

P

L

L

A

A

G

H

D

D

Q

E

Q

K

R

N

V

V

A

A

M

L

H
|
H

M
|
M

V
|
V

S

S

S

K

E

E

T

N

L

L

F

F

W

W

E

E

T

T

M

M

E

E

K

A

L

L

K

K

A

E

L

E

G

G

A

A

S

S

S
|
S

I

I

L
|
L

V

V

L

L

P

P

I

I

E

E

K

K

M

M

M

L

E

K

binding adenosine monophosphate: C101 (= C104), D166 (= D169), L167 (= L170), V168 (= V171), S169 (= S172), S170 (≠ T173), G171 (= G174), A172 (= A175), T173 (= T176)
binding histidine: Y225 (= Y228), M227 (= M230), L228 (≠ M231), H229 (= H232), G244 (= G247), V245 (≠ A248), E246 (= E249), R247 (= R250), P248 (= P251), T249 (= T252), H263 (= H266), M264 (= M267), V265 (= V268), S285 (= S288), L287 (= L290)

4yb7I Adenosine triphosphate phosphoribosyltransferase from campylobacter jejuni in complex with atp (see paper)
67% identity, 99% coverage: 4:299/299 of query aligns to 1:292/292 of 4yb7I

query
sites
4yb7I

N

N

T

T

R

R

L

L

R

R

I

I

A

A

M

I

Q
|
Q

K

K

S

S

G
|
G

R
|
R

L
|
L

S

S

D

K

D

E

S

S

R

I

E

E

L

L

L

L

A

S

R

E

C

C

G

G

I

V

K

K

I

M

N

H

L

I

H

H

T

E

Q

Q

R

S

L

L

I

I

A

A

M

F

A

S

E

T

N

N

M

L

P

P

I

I

D

D

I

I

L

L

R

R

V

V

R
|
R

D
|
D

D
|
D

D

D

I

I

P

P

G

G

L

L

V

I

M

F

D

D

G

G

V

V

V

V

D

D

L

L

G

G

I

I

I

I

G

G

E

E

N
|
N

V

V

L

L

E

E

E

E

E

N

L

E

L

L

N

E

R

R

R

Q

A

S

Q

L

G

G

E

E

D

N

P

P

R

S

Y

Y

F

K

T

L

L

L

R

K

R

K

L

L

D

D

F

F

G
|
G

G
x
Y

C
|
C

R

R

L

L

S

S

L

L

A

A

T

L

P

P

V

Q

D

E

E

N

A

L

W

K

D

D

G

-

P

-

L

-

S

-

L

F

N

E

G

G

K

L

R

R

I

I

A

A

T

T

S

S

Y

Y

P

P

H

Q

L

L

L

L

K

K

R

R

Y

F

L

M

D

K

Q

E

K

N

G

G

I

I

S

N

F

Y

K

K

S

N

C

C

L

T

L

L

N

T

G

G

S

S

V

V

E

E

V

V

A

A

P

P

R

R

A

A

G

N

L

L

A

A

D

D

A

A

I

I

C

C

D

D

L
|
L

V
|
V

S
|
S

T
x
S

G
|
G

A

A

T
|
T

L

L

E

Q

A

A

N

N

G

N

L

L

R

K

E

E

V

V

E

K

V

V

I

I

Y

Y

R

E

S

S

K

R

A

A

C

C

L

L

I

I

Q

Q

R

K

D

E

G

N

E

A

M

L

E

S

E

K

S

E

K

K

Q

Q

Q

A

L

L

I

V

D

D

K

K

L

I

L

M

T

L

R

R

I

V

Q

A

G

G

V

V

I

M

Q

Q

A

A

R

R

E

E

S

S

K

K

Y

Y

I

I

M

M

M

L

H

H

A

A

P

P

T

K

E

E

R

K

L

L

D

D

E

K

V

I

I

Q

A

A

L

L

L

L

P

P

G

G

A

V

E

E

R

R

P

P

T

T

I

I

L

L

P

P

L

L

A

A

G

H

D

D

Q

E

Q

K

R

N

V

V

A

A

M

L

H

H

M

M

V

V

S

S

S

K

E

E

T

N

L

L

F

F

W

W

E

E

T

T

M

M

E

E

K

A

L

L

K

K

A

E

L

E

G

G

A

A

S

S

S

S

I

I

L

L

V

V

L

L

P

P

I

I

E

E

K

K

M

M

M

L

E

K

binding adenosine-5'-triphosphate: Q9 (= Q12), G12 (= G15), R13 (= R16), L14 (= L17), R51 (= R54), D52 (= D55), D53 (= D56), N72 (= N75), G99 (= G102), Y100 (≠ G103), C101 (= C104), L163 (= L170), S165 (= S172)
binding magnesium ion: D52 (= D55), D53 (= D56)
binding phosphate ion: V164 (= V171), S165 (= S172), S166 (≠ T173), G167 (= G174), T169 (= T176)

7dahC Adenosine triphosphate phosphoribosyltransferase from vibrio cholerae in complex with atp and prpp
67% identity, 98% coverage: 6:299/299 of query aligns to 3:288/288 of 7dahC

query
sites
7dahC

R

R

L

L

R

R

I

I

A

A

M

I

Q
|
Q

K

K

S

K

G

G

R
|
R

L

L

S

S

D

Q

D

E

S

C

R

Q

E

E

L

L

L

L

A

K

R

K

C

C

G

G

I

V

K

K

I

F

N

N

L

I

H

M

T

G

Q

E

R

R

L

L

I

V

A

V

M

H

A

S

E

L

N

N

M

M

P

P

I

I

D

D

I

L

L

L

R

L

V

V

R
|
R

D
|
D

D
|
D

D

D

I

I

P

P

G

G

L

L

V

I

M

M

D

D

G

G

V

V

V

V

D

D

L

L

G

G

I

F

I

V

G

G

E

E

N
|
N

V

V

L

L

E

E

E

E

E

T

L

R

L

L

N

D

R

R

R

L

A

A

Q

L

G

N

E

Q

D

R

P

N

R

E

Y

F

F

T

T

T

L

L

R

R

R

R

L

M

D

D

F

F

G
|
G

G
|
G

C
|
C

R

R

L

L

S

S

L

I

A

A

T

I

P

E

V

K

D

D

E

A

A

E

W

Y

D

R

G

G

P

P

L

Q

S

D

L

L

N

N

G

G

K

K

R

R

I

I

A

A

T

T

S

T

Y

Y

P

P

H

Q

L

L

L

L

K

K

R

A

Y

Y

L

M

D

D

Q

R

K

Q

G

G

I

V

S

D

F

F

K

S

S

T

C

C

L

M

L

L

N

T

G
|
G

S
|
S

V

V

E
|
E

V

V

A

A

P

P

R

R

A

A

G

G

L

L

A

A

D

D

A

A

I

I

C

A

D
|
D

L
|
L

V
|
V

S
|
S

T
|
T

G
|
G

A
|
A

T
|
T

L

L

E

E

A

A

N

N

G

G

L

L

R

K

E

E

V

V

E

E

V

V

I

I

Y

F

R

E

S

S

K

K

A

A

C

T

L

L

I

I

Q

Q

R

R

D

P

G

G

E

A

M

F

E

A

E

A

S

D

K

K

Q

A

Q

A

L

L

I

I

D

D

K

K

L

L

L

L

T

T

R

R

I

M

Q

H

G

G

V

V

I

Q

Q

Q

A

A

R

K

E

E

S

S

K

K

Y

Y

I

I

M

M

M

L

H

H

A

A

P

P

T

V

E

E

R

K

L

L

D

A

E

Q

V

I

I

K

A

T

L

L

L

L

P

P

G

G

A

A

E

E

R

D

P

P

T

T

I

V

L

-

P

P

L

L

A

-

G

-

D

-

Q

-

Q

-

R

-

V

-

A

A

M

V

H

H

M

M

V

V

S

S

S

S

E

E

T

N

L

L

F

F

W

W

E

E

T

T

M

M

E

E

K

Q

L

L

K

K

A

A

L

L

G

G

A

A

S

S

S

S

I

I

L

L

V

V

L

L

P

P

I

I

E

E

K

K

M

M

M

M

E

E

binding adenosine-5'-triphosphate: Q9 (= Q12), R13 (= R16), R51 (= R54), D52 (= D55), D53 (= D56), N72 (= N75), G99 (= G102), G100 (= G103), C101 (= C104), L167 (= L170), S169 (= S172)
binding magnesium ion: D52 (= D55), D53 (= D56)
binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: G150 (= G153), S151 (= S154), E153 (= E156), D166 (= D169), L167 (= L170), V168 (= V171), S169 (= S172), T170 (= T173), G171 (= G174), A172 (= A175), T173 (= T176)

4yb6E Adenosine triphosphate phosphoribosyltransferase from campylobacter jejuni in complex with the inhibitors amp and histidine (see paper)
66% identity, 99% coverage: 4:299/299 of query aligns to 1:293/293 of 4yb6E

query
sites
4yb6E

N

N

T

T

R

R

L

L

R

R

I

I

A

A

M

I

Q

Q

K

K

S

S

G

G

R

R

L

L

S

S

D

K

D

E

S

S

R

I

E

E

L

L

L

L

A

S

R

E

C

C

G

G

I

V

K

K

I

M

N

H

L

I

H

S

T

-

Q

-

R

-

L

L

I

I

A

A

M

F

A

S

E

T

N

N

M

L

P

P

I

I

D

D

I

I

L

L

R

R

V

V

R

R

D

D

D

D

D

D

I

I

P

P

G

G

L

L

V

I

M

F

D

D

G

G

V

V

V

V

D

D

L

L

G

G

I

I

I

I

G

G

E

E

N

N

V

V

L

L

E

E

E

E

E

N

L

E

L

L

N

E

R

R

R

Q

A

S

Q

L

G

G

E

E

D

N

P

P

R

S

Y

Y

F

K

T

L

L

L

R

K

R

K

L

L

D

D

F

F

G
|
G

G

Y

C
|
C

R

R

L

L

S

S

L

L

A

A

T

L

P

P

V

Q

D

E

E

N

A

K

W

F

D

Q

G

N

P

L

L

K

S

D

L

F

N

E

G

G

K

L

R

R

I

I

A

A

T

T

S

S

Y

Y

P

P

H

Q

L

L

L

L

K

K

R

R

Y

F

L

M

D

K

Q

E

K

N

G

G

I

I

S

N

F

Y

K

K

S

N

C

C

L

T

L

L

N

T

G

G

S

S

V

V

E

E

V

V

A

A

P

P

R

R

A

A

G

N

L

L

A

A

D

D

A

A

I

I

C

C

D
|
D

L
|
L

V
|
V

S
|
S

T
x
S

G
|
G

A
|
A

T
|
T

L

L

E

Q

A

A

N

N

G

N

L

L

R

K

E

E

V

V

E

K

V

V

I

I

Y

Y

R

E

S

S

K

R

A

A

C

C

L

L

I

I

Q

Q

R

K

D

E

G

N

E

A

M

L

E

S

E

K

S

E

K

K

Q

Q

Q

A

L

L

I

V

D

D

K

K

L

I

L

M

T

L

R

R

I

V

Q

A

G

G

V

V

I

M

Q

Q

A

A

R

R

E

E

S
|
S

K
|
K

Y
|
Y

I

I

M
|
M

M
x
L

H
|
H

A

A

P

P

T

K

E

E

R

K

L

L

D

D

E

K

V

I

I

Q

A

A

L

L

L

L

P

P

G
|
G

A
x
V

E
|
E

R
|
R

P
|
P

T
|
T

I

I

L

L

P

P

L

L

A

A

G

H

D

D

Q

E

Q

K

R

N

V

V

A

A

M

L

H
|
H

M
|
M

V
|
V

S

S

S

K

E

E

T

N

L

L

F

F

W

W

E

E

T

T

M

M

E

E

K

A

L

L

K

K

A

E

L

E

G

G

A

A

S

S

S
|
S

I

I

L
|
L

V

V

L

L

P

P

I

I

E

E

K

K

M

M

M

L

E

K

binding adenosine monophosphate: G96 (= G102), C98 (= C104), D163 (= D169), L164 (= L170), V165 (= V171), S166 (= S172), S167 (≠ T173), G168 (= G174), A169 (= A175), T170 (= T176)
binding histidine: Y222 (= Y228), M224 (= M230), L225 (≠ M231), H226 (= H232), G241 (= G247), V242 (≠ A248), E243 (= E249), R244 (= R250), P245 (= P251), T246 (= T252), H260 (= H266), M261 (= M267), V262 (= V268), S282 (= S288), L284 (= L290)
binding magnesium ion: S220 (= S226), K221 (= K227)

5ubgA Catalytic core domain of adenosine triphosphate phosphoribosyltransferase from campylobacter jejuni with bound phosphoribosyl-atp (see paper)
64% identity, 74% coverage: 4:225/299 of query aligns to 1:222/222 of 5ubgA

query
sites
5ubgA

N

N

T

T

R

R

L

L

R

R

I

I

A

A

M

I

Q
|
Q

K

K

S
|
S

G
|
G

R
|
R

L
|
L

S

S

D

K

D

E

S

S

R

I

E

E

L

L

L

L

A

S

R

E

C

C

G

G

I

V

K

K

I

M

N
x
H

L

I

H
|
H

T

E

Q

Q

R

S

L

L

I

I

A

A

M

F

A

S

E

T

N

N

M

L

P

P

I

I

D

D

I

I

L

L

R

R

V

V

R
|
R

D
|
D

D
|
D

D

D

I

I

P

P

G

G

L

L

V

I

M

F

D

D

G

G

V

V

V

V

D

D

L

L

G

G

I

I

I

I

G

G

E

E

N
|
N

V

V

L

L

E

E

E

E

E

N

L

E

L

L

N

E

R

R

R

Q

A

S

Q

L

G

G

E

E

D

N

P

P

R

S

Y

Y

F

K

T

L

L

L

R

K

R

K

L

L

D

D

F

F

G
|
G

G
x
Y

C
|
C

R

R

L

L

S

S

L

L

A

A

T

L

P

P

V

Q

D

E

E

N

A

K

W

F

D

Q

G

N

P

L

L

K

S

D

L

F

N

E

G

G

K

L

R

R

I

I

A

A

T

T

S

S

Y

Y

P

P

H

Q

L

L

L

L

K

K

R

R

Y

F

L

M

D

K

Q

E

K

N

G

G

I

I

S

N

F

Y

K

K

S

N

C

C

L

T

L

L

N

T

G

G

S

S

V

V

E

E

V

V

A

A

P

P

R

R

A

A

G

N

L

L

A

A

D

D

A

A

I

I

C

C

D
|
D

L
|
L

V
|
V

S
|
S

T
x
S

G
|
G

A
|
A

T
|
T

L

L

E

Q

A

A

N

N

G

N

L

L

R

K

E

E

V

V

E

K

V

V

I

I

Y

Y

R

E

S

S

K

R

A

A

C

C

L

L

I

I

Q

Q

R

K

D

E

G

N

E

A

M

L

E

S

E

K

S

E

K

K

Q

Q

Q

A

L

L

I

V

D

D

K

K

L

I

L

M

T

L

R

R

I

V

Q

A

G

G

V

V

I

M

Q

Q

A

A

R

R

E

E

binding phosphoribosyl atp : Q9 (= Q12), S11 (= S14), G12 (= G15), R13 (= R16), L14 (= L17), R51 (= R54), D52 (= D55), D53 (= D56), N72 (= N75), G99 (= G102), Y100 (≠ G103), C101 (= C104), D166 (= D169), L167 (= L170), V168 (= V171), S169 (= S172), S170 (≠ T173), G171 (= G174), A172 (= A175), T173 (= T176)
binding zinc ion: H30 (≠ N33), H32 (= H35), D52 (= D55), D53 (= D56)

5ub9A Catalytic core domain of adenosine triphosphate phosphoribosyltransferase from campylobacter jejuni (see paper)
64% identity, 74% coverage: 5:225/299 of query aligns to 1:220/220 of 5ub9A

query
sites
5ub9A

T

T

R

R

L

L

R

R

I

I

A

A

M

I

Q

Q

K

K

S

S

G

G

R

R

L

L

S

S

D

K

D

E

S

S

R

I

E

E

L

L

L

L

A

S

R

E

C

C

G

G

I

V

K

K

I

M

N
x
H

L

I

H
|
H

T

E

Q

Q

R

S

L

L

I

I

A

A

M

F

A

S

E

T

N

N

M

L

P

P

I

I

D

D

I

I

L

L

R

R

V

V

R

R

D

D

D

D

D

D

I

I

P

P

G

G

L

L

V

I

M

F

D

D

G

G

V

V

V

V

D

D

L

L

G

G

I

I

I

I

G

G

E

E

N

N

V

V

L

L

E

E

E

E

E

N

L

E

L

L

N

E

R

R

R

Q

A

S

Q

L

G

G

E

E

D

N

P

P

R

S

Y

Y

F

K

T

L

L

L

R

K

R

K

L

L

D

D

F

F

G

G

G

Y

C

C

R

R

L

L

S

S

L

L

A

A

T

L

P

P

V

Q

D

E

E

N

A

K

W

F

D

N

G

L

P

K

L

-

S

D

L

F

N

E

G

G

K

L

R

R

I

I

A

A

T

T

S

S

Y

Y

P

P

H

Q

L

L

L

L

K

K

R

R

Y

F

L

M

D

K

Q

E

K

N

G

G

I

I

S

N

F

Y

K

K

S

N

C

C

L

T

L

L

N

T

G

G

S

S

V

V

E

E

V

V

A

A

P

P

R

R

A

A

G

N

L

L

A

A

D

D

A

A

I

I

C

C

D

D

L

L

V

V

S

S

T

S

G

G

A

A

T

T

L

L

E

Q

A

A

N

N

G

N

L

L

R

K

E

E

V

V

E

K

V

V

I

I

Y

Y

R

E

S

S

K

R

A

A

C

C

L

L

I

I

Q

Q

R

K

D

E

G

N

E

A

M

L

E

S

E

K

S

E

K

K

Q

Q

Q

A

L

L

I

V

D

D

K

K

L

I

L

M

T

L

R

R

I

V

Q

A

G

G

V

V

I

M

Q

Q

A

A

R

R

E

E

binding zinc ion: H29 (≠ N33), H31 (= H35)

5ubiA Catalytic core domain of adenosine triphosphate phosphoribosyltransferase from campylobacter jejuni with bound prpp (see paper)
63% identity, 73% coverage: 4:221/299 of query aligns to 1:218/218 of 5ubiA

query
sites
5ubiA

N

N

T

T

R

R

L

L

R

R

I

I

A

A

M

I

Q

Q

K

K

S

S

G

G

R
|
R

L

L

S

S

D

K

D

E

S

S

R

I

E

E

L

L

L

L

A

S

R

E

C

C

G

G

I

V

K

K

I

M

N
x
H

L

I

H
|
H

T

E

Q

Q

R

S

L

L

I

I

A

A

M

F

A

S

E

T

N

N

M

L

P

P

I

I

D

D

I

I

L

L

R

R

V

V

R

R

D
|
D

D
|
D

D

D

I

I

P

P

G

G

L

L

V

I

M

F

D

D

G

G

V

V

V

V

D

D

L

L

G

G

I

I

I

I

G

G

E

E

N

N

V

V

L

L

E

E

E

E

E

N

L

E

L

L

N

E

R

R

R

Q

A

S

Q

L

G

G

E

E

D

N

P

P

R

S

Y

Y

F

K

T

L

L

L

R

K

R

K

L

L

D

D

F

F

G

G

G

Y

C

C

R

R

L

L

S

S

L

L

A

A

T

L

P

P

V

Q

D

E

E

N

A

K

W

F

D

Q

G

N

P

L

L

K

S

D

L

F

N

E

G

G

K

L

R

R

I

I

A

A

T

T

S

S

Y

Y

P

P

H

Q

L

L

L

L

K

K

R

R

Y

F

L

M

D

K

Q

E

K

N

G

G

I

I

S

N

F

Y

K

K

S

N

C

C

L

T

L

L

N

T

G

G

S

S

V

V

E

E

V

V

A

A

P

P

R

R

A

A

G

N

L

L

A

A

D

D

A

A

I

I

C

C

D
|
D

L
|
L

V
|
V

S
|
S

T
x
S

G
|
G

A
|
A

T
|
T

L

L

E

Q

A

A

N

N

G

N

L

L

R

K

E

E

V

V

E

K

V

V

I

I

Y

Y

R

E

S

S

K

R

A

A

C

C

L

L

I

I

Q

Q

R

K

D

E

G

N

E

A

M

L

E

S

E

K

S

E

K

K

Q

Q

Q

A

L

L

I

V

D

D

K

K

L

I

L

M

T

L

R

R

I

V

Q

A

G

G

V

V

I

M

binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: R13 (= R16), D52 (= D55), D166 (= D169), L167 (= L170), V168 (= V171), S169 (= S172), S170 (≠ T173), G171 (= G174), A172 (= A175), T173 (= T176)
binding zinc ion: H30 (≠ N33), H30 (≠ N33), H32 (= H35), H32 (= H35), D52 (= D55), D53 (= D56)

2vd3A The structure of histidine inhibited hisg from methanobacterium thermoautotrophicum
36% identity, 98% coverage: 6:298/299 of query aligns to 4:288/289 of 2vd3A

query
sites
2vd3A

R

K

L

I

R

R

I

I

A

A

M

V

Q

P

K

S

S

K

G

G

R

R

L

I

S

S

D

E

D

P

S

A

R

I

E

R

L

L

L

L

A
x
E

R

N

C

A

G

G

I

V

K
x
G

I

L

-

K

N

D

L

T

H

V

T

N

Q

R

R

K

L

L

I

F

A

S

M

K

A

T

E
x
Q

N

H

M

P

P

Q

I

I

D

E

I

V

L

M

R

F

V

S

R

R

D

A

D

A

D

D

I

I

P

P

G

E

L

F

V

V

M

A

D

D

G

G

V

A

V

A

D

D

L

L

G

G

I

I

I

T

G

G

E

Y

N

D

V

L

L

I

E

V

E

E

E

-

L

-

L

-

N

-

R

-

R

-

A

-

Q

R

G

G

E

S

D

D

P

V

R

E

Y

I

F

-

T

-

L

L

R

E

R

D

L

L

D

K

F

Y

G

G

G

R

C

A

R

S

L

L

S

V

L

L

A

A

T

A

P

P

V

E

D

D

E

S

A

T

W

I

D

R

G

G

P

P

L

E

S

D

L

I

-

P

N

R

G

G

K

A

R

V

I

I

A

A

T

T

S

E

Y

F

P

P

H

G

L

I

L

T

K

E

R

N

Y

Y

L

L

D

R

Q

E

K

H

G

G

I

I

S

D

F

A

K

E

S

V

C

V

L

E

L

L

N

T

G

G

S

S

V

T

E

E

V

I

A

A

P

P

R

F

A

I

G

G

L

V

A

A

D

D

A

L

I

I

C

T

D
|
D

L
|
L

V

S

S

S

T

T

G

G

A

T

T

T

L

L

E

R

A

M

N

N

G

H

L

L

R

R

E

V

V

I

E

D

V

T

I

I

Y

L

R

E

S

S

K

S

A

V

C

K

L

L

I

I

Q

A

R

-

D

N

G

R

E

E

M

S

E

Y

E

A

S

T

K

K

Q

S

Q

G

L

I

I

I

D

E

K

E

L

L

L

R

T

T

R

G

I

I

Q

R

G

G

V

V

I

I

Q

D

A

A

R

E

E

G

S

K

K

R

Y

L

I

V

M

M

M

L

H

N

A

I

P

D

T

R

E

K

R

N

L

L

D

D

E

R

V

V

I

R

A

A

L

L

L

M

P

P

G
|
G

A
x
M

E
x
T

R
x
G

P

P

T
|
T

I

V

L

S

P

E

L

V

A

L

G

S

D

D

Q

N

Q

G

R

V

V

V

A

A

M

V

H
|
H

M
x
A

V
|
V

S

V

S

D

E

E

T

K

L

E

F

V

W

F

E

N

T

L

M

I

E

N

K

R

L

L

K

K

A

A

L

V

G

G

A

A

S

R

S

D

I

I

L

L

V

V

L

V

P

P

I

I

E

E

K

R

M

I

M

I

binding histidine: G237 (= G247), M238 (≠ A248), T239 (≠ E249), G240 (≠ R250), T242 (= T252), H256 (= H266), A257 (≠ M267), V258 (= V268)
binding magnesium ion: E24 (≠ A26), G29 (≠ K31), Q43 (≠ E44), D160 (= D169), L161 (= L170)

5lhtA Atp phosphoribosyltransferase from mycobacterium tuberculosis in complex with the allosteric activator 3-(2-thienyl)-l-alanine (see paper)
32% identity, 95% coverage: 7:290/299 of query aligns to 2:275/284 of 5lhtA

query
sites
5lhtA

L

L

R

R

I

V

A

A

M

V

Q

P

K

N

S

K

G

G

R

A

L

L

S

S

D

E

D

P

S

A

R

T

E

E

L

I

L

L

A

A

R

E

C

A

G

G

I

Y

K

R

I

R

N

R

L

T

H

D

T

S

Q

K

R

D

L

L

I

T

A

V

M

I

A

D

E

P

N

V

M

N

P

N

I

V

D

E

I

F

L

F

R

F

V

L

R

R

D

P

D

K

D

D

I

I

P

A

G

I

L

Y

V

V

M

G

D

S

G

G

V

E

V

L

D

D

L

F

G

G

I

I

I

T

G

G

E

R

N

D

V

L

L

V

E

C

E

D

E

S

L

G

L

A

N

Q

R

V

R

R

A

E

Q

R

G

-

E

-

D

-

P

-

R

-

Y

-

F

-

T

-

L

-

R

L

R

A

L

L

D

G

F

F

G

G

G

S

C

S

R

S

L

F

S

R

L

Y

A

A

T

A

P

P

V

A

D

G

E

R

A

N

W

W

D

T

G

-

P

T

L

A

S

D

L

L

N

A

G

G

K

M

R

R

I

I

A

A

T

T

S

A

Y

Y

P

P

H

N

L

L

L

V

K

R

R

K

Y

D

L

L

D

A

Q

T

K

K

G

G

I

I

S

E

F

A

K

T

S

V

C

I

L

R

L

L

N

D

G

G

S

A

V

V

E

E

V

I

A

S

P

V

R

Q

A

L

G

G

L

V

A

A

D

D

A

A

I

I

C

A

D

D

L

V

V

V

S

G

T

S

G

G

A

R

T

T

L

L

E

S

A

Q

N

H

G

D

L

L

R

V

E

A

V

F

-

G

E

E

V

P

I

L

Y

C

R

D

S

S

K

E

A

A

C

V

L

L

I

I

Q

E

R

R

D

A

G

G

E

T

M

D

E

G

E

Q

S

D

K

Q

Q

T

Q

E

L

A

I

R

D

D

K

Q

L

L

L

V

T

A

R

R

I

V

Q

Q

G

G

V

V

I

V

Q

F

A

G

R

Q

E

Q

S

Y

K

L

Y

M

I

L

M
x
D

M
x
Y

H
x
D

A

C

P

P

T

R

E

S

R

A

L

L

D

K

E

K

V

A

I

T

A

A

L

I

L

T

P

P

G

G

A

L

E

E

R

S

P

P

T

T

I

I

L

A

P

P

L

L

A

A

G

-

D

D

Q

P

Q

D

R

W

V

V

A

A

M

I

H

R

M

A

V

L

S

V

S

P

E

R

T

R

L

D

F

V

W

N

E

G

T

I

M

M

E

D

K

E

L

L

K

A

A

A

L

I

G

G

A

A

S

K

S
x
A

I

I

L
|
L

binding beta(2-thienyl)alanine: D216 (≠ M230), Y217 (≠ M231), D218 (≠ H232), A273 (≠ S288), L275 (= L290)

1nh8A Atp phosphoribosyltransferase (atp-prtase) from mycobacterium tuberculosis in complex with amp and histidine (see paper)
32% identity, 95% coverage: 7:290/299 of query aligns to 2:267/276 of 1nh8A

query
sites
1nh8A

L

L

R

R

I

V

A

A

M

V

Q

P

K

N

S

K

G

G

R

A

L

L

S

S

D

E

D

P

S

A

R

T

E

E

L

I

L

L

A

A

R

E

C

A

G

G

I

Y

K

R

I

R

N

R

L

T

H

D

T

S

Q

K

R

D

L

L

I

T

A

V

M

I

A

D

E

P

N

V

M

N

P

N

I

V

D

E

I

F

L

F

R

F

V

L

R

R

D

P

D

K

D

D

I

I

P

A

G

I

L

Y

V

V

M

G

D

S

G

G

V

E

V

L

D

D

L

F

G

G

I

I

I

T

G

G

E

R

N

D

V

L

L

V

E

C

E

D

E

S

L

G

L

A

N

Q

R

V

R

R

A

E

Q

R

G

-

E

-

D

-

P

-

R

-

Y

-

F

-

T

-

L

-

R

L

R

A

L

L

D

G

F

F

G

G

G

S

C

S

R

S

L

F

S

R

L

Y

A

A

T

A

P

P

V

A

D

G

E

R

A

N

W

W

D

T

G

-

P

T

L

A

S

D

L

L

N

A

G

G

K

M

R

R

I

I

A

A

T

T

S

A

Y

Y

P

P

H

N

L

L

L

V

K

R

R

K

Y

D

L

L

D

A

Q

T

K

K

G

G

I

I

S

E

F

A

K

T

S

V

C

I

L

R

L

L

N

D

G

G

S

A

V

V

E

E

V

I

A

S

P

V

R

Q

A

L

G

G

L

V

A

A

D

D

A

A

I

I

C

A

D

D

L
x
V

V
|
V

S
x
G

T
x
S

G
|
G

A
x
R

T
|
T

L

L

E

S

A

Q

N

H

G

D

L

L

R

V

E

A

V

F

-

G

E

E

V

P

I

L

Y

C

R

D

S

S

K

E

A

A

C

V

L

L

I

I

Q

E

R

R

D

-

G

-

E

-

M

-

E

A

E

E

S

A

K

R

Q

D

Q

Q

L

L

I

V

D

-

K

-

L

-

L

-

T

A

R

R

I

V

Q

Q

G

G

V

V

I

V

Q

F

A

G

R

Q

E

Q

S

Y

K

L

Y

M

I

L

M
x
D

M
x
Y

H
x
D

A

C

P

P

T

R

E

S

R

A

L

L

D

K

E

K

V

A

I

T

A

A

L

I

L

T

P

P

G

G

A

L

E

E

R

S

P

P

T

T

I

I

L

A

P

P

L

L

A

A

G

-

D

D

Q

P

Q

D

R

W

V

V

A

A

M

I

H

R

M

A

V

L

S

V

S

P

E

R

T

R

L

D

F

V

W

N

E

G

T

I

M

M

E

D

K

E

L

L

K

A

A

A

L

I

G

G

A

A

S

K

S
x
A

I

I

L
|
L

binding adenosine monophosphate: V155 (≠ L170), V156 (= V171), G157 (≠ S172), S158 (≠ T173), G159 (= G174), R160 (≠ A175), T161 (= T176)
binding histidine: D208 (≠ M230), Y209 (≠ M231), D210 (≠ H232), A265 (≠ S288), L267 (= L290)

5u99A Transition state analysis of adenosine triphosphate phosphoribosyltransferase (see paper)
31% identity, 95% coverage: 7:290/299 of query aligns to 4:269/278 of 5u99A

query
sites
5u99A

L

L

R

R

I

V

A

A

M

V

Q

P

K

N

S

K

G

G

R

A

L
|
L

S

S

D

E

D

P

S

A

R

T

E

E

L

I

L

L

A

A

R

E

C

A

G

G

I

Y

K

R

I

R

N

R

L

T

H

D

T

S

Q

K

R

D

L

L

I

T

A

V

M

I

A

D

E

P

N

V

M

N

P

N

I

V

D

E

I

F

L

F

R

F

V

L

R
|
R

D

P

D

K

D

D

I

I

P

A

G

I

L

Y

V

V

M

G

D

S

G

G

V

E

V

L

D

D

L

F

G

G

I

I

I

T

G

G

E

R

N
x
D

V
x
L

L

V

E

C

E

D

E

S

L

G

L

A

N

Q

R

V

R

R

A

E

Q

R

G

-

E

-

D

-

P

-

R

-

Y

-

F

-

T

-

L

-

R

L

R

A

L

L

D

G

F

F

G
|
G

G
x
S

C
x
S

R

S

L

F

S

R

L

Y

A

A

T

A

P

P

V

A

D

G

E

R

A

N

W

W

D

T

G

-

P

T

L

A

S

D

L

L

N

A

G

G

K

M

R

R

I

I

A

A

T

T

S

A

Y
|
Y

P

P

H

N

L

L

L

V

K

R

R

K

Y

D

L

L

D

A

Q

T

K

K

G

G

I

I

S

E

F

A

K

T

S

V

C

I

L

R

L

L

N

D

G

G

S

A

V

V

E

E

V

I

A

S

P

V

R

Q

A

L

G

G

L

V

A

A

D

D

A

A

I

I

C

A

D

D

L
x
V

V

V

S
x
G

T

S

G

G

A

R

T

T

L

L

E

S

A

Q

N

H

G

D

L

L

R

V

E

A

V

F

-

G

E

E

V

P

I

L

Y

C

R

D

S

S

K

E

A

A

C

V

L

L

I

I

Q

E

R

R

D

-

G

-

E

-

M

-

E

-

E

-

S

A

K

Q

Q

T

Q

E

L

A

I

R

D

D

K

Q

L

L

L

V

T

A

R

R

I

V

Q

Q

G

G

V

V

I

V

Q

F

A

G

R

Q

E

Q

S

Y

K

L

Y

M

I

L

M

D

M

Y

H

D

A

C

P

P

T

R

E

S

R

A

L

L

D

K

E

K

V

A

I

T

A

A

L

I

L

T

P

P

G

G

A

L

E

E

R

S

P

P

T

T

I

I

L

A

P

P

L

-

A

-

G

-

D

D

Q

P

Q

D

R

W

V

V

A

A

M

I

H

R

M

A

V

L

S

V

S

P

E

R

T

R

L

D

F

V

W

N

E

G

T

I

M

M

E

D

K

E

L

L

K

A

A

A

L

I

G

G

A

A

S

K

S

A

I

I

L

L

binding adenosine-5'-triphosphate: L14 (= L17), R51 (= R54), D72 (≠ N75), L73 (≠ V76), G90 (= G102), S91 (≠ G103), S92 (≠ C104), Y118 (= Y131), V157 (≠ L170), G159 (≠ S172)

6czmE Crystal structure of medicago truncatula atp-phosphoribosyltransferase in tense form (see paper)
25% identity, 98% coverage: 7:299/299 of query aligns to 10:328/342 of 6czmE

query
sites
6czmE

L

I

R

R

I

L

A

G

M

L

Q

P

K

S

S

K

G

G

R

R

L

M

S

S

D

S

D

D

S

T

R

L

E

D

L

L

L

L

A

K

R

D

C

C

G

Q

I

L

K

S

I

V

-

K

N

Q

L

V

H

N

T

P

Q

R

R

Q

L

Y

I

V

A

A

M

Q

A

I

E

P

N

Q

M

I

P

S

-

N

I

L

D

E

I

V

L

W

R

F

V

Q

R

R

D

P

D

K

D

D

I

I

P

V

G

R

L

K

V

L

M

L

D

S

G

G

V

D

V

L

D

D

L

L

G

G

I

I

I

V

G

G

E

L

N

D

V

V

L

L

E

T

E

E

E

-

L

-

L

-

N

-

R

-

R

F

A

G

Q

Q

G

G

E

N

D

E

P

D

R

L

Y

I

F

V

T

V

L

H

R

E

R

A

L

L

D

E

F

Y

G

G

G

D

C
|
C

R

R

L

L

S

S

L

I

A

A

T

I

P

P

-

Q

-

Y

-

G

-

I

-

F

-

E

-

N

-

V

-

N

-

S

V

L

D

E

E

E

A

L

W

A

D

K

G

M

P

P

L

Q

S

W

L

T

N

E

G

D

K

K

-

P

-

L

R

R

I

V

A

A

T

T

S

G

Y

F

P

T

H

Y

L

L

L

G

K

P

R

K

Y

F

L

M

D

K

Q

D

K

N

G

G

I

I

-

K

-

H

-

V

S

A

F

F

K

S

S

T

C

A

L

-

L

-

N

D

G

G

S

A

V

L

E
|
E

V

A

A

A

P

P

R

A

A

M

G

G

L

I

A

A

D

D

A

A

I

I

C

L

D
|
D

L
|
L

V
|
V

S
|
S

T
x
S

G
|
G

A
x
T

T
|
T

L

L

E

K

A

E

N

N

G

N

L

L

R

K

E

E

V

I

E

E

-

G

-

G

-

T

-

V

-

L

-

E

-

S

-

Q

-

A

V

A

I

L

Y

V

R

A

S

S

K

R

A

R

C

S

L

M

I

I

Q

G

R

R

D

K

G

G

E

V

M

L

E

-

E

E

S

T

K

T

Q

H

Q

E

L

M

I

L

D

E

K

R

L

L

L

E

T

A

R

H

I

L

Q

R

G

A

V

M

I

G

Q

Q

A

F

R

T

E

V

S
x
V

K
x
A

Y
x
N

I

M

M

R

M

G

H

S

A

S

P

A

T

E

E

E

R

V

L

A

D

E

E

R

V

V

I

L

A

S

L

Q

-

P

-

S

L

L

P

A

G
|
G

A
x
L

E
x
Q

R
x
G

P

P

T
|
T

I

V

L

S

P

P

L
x
V

A

F

G

C

D

K

Q

R

-

D

-

G

-

K

-

V

-

S

-

A

Q

D

R

Y

V

Y

A

A

M

I

H
x
V

M
x
I

V
x
C

S

V

S

P

E

K

T

K

L

A

F

L

W

Y

E

K

T

S

M

I

E

Q

K

Q

L

L

K

R

A

A

L

I

G

G

A

G

S

S

S
x
G

I

V

L
|
L

V

V

L

S

P

P

I

L

E

T

K

Y

M

I

M

F

E

D

binding adenosine monophosphate: C104 (= C104), E169 (= E156), D182 (= D169), L183 (= L170), V184 (= V171), S185 (= S172), S186 (≠ T173), G187 (= G174), T188 (≠ A175), T189 (= T176)
binding histidine: V247 (≠ S226), A248 (≠ K227), N249 (≠ Y228), G270 (= G247), L271 (≠ A248), Q272 (≠ E249), G273 (≠ R250), T275 (= T252), V279 (≠ L256), V295 (≠ H266), I296 (≠ M267), C297 (≠ V268), G317 (≠ S288), L319 (= L290)

1z7nF Atp phosphoribosyl transferase (hiszg atp-prtase) from lactococcus lactis with bound prpp substrate (see paper)
33% identity, 61% coverage: 7:188/299 of query aligns to 2:174/205 of 1z7nF

query
sites
1z7nF

L

I

R

K

I

I

A

A

M

I

Q

T

K

K

S

-

G

G

R

R

L

I

S

Q

D

K

D

Q

S

V

R

T

E

K

L

L

L

L

A

E

R

N

C

A

G

D

I

Y

K

D

I

V

N

E

-

P

-

I

L

L

H

N

T

L

Q

G

R

R

L

E

I

L

A

Q

M

I

A

K

E

T

N

K

M

D

P

D

I

L

D

Q

I

I

L

I

R

F

V

G

R

K

D

P

D

N

D

D

I

V

P

I

G

T

L

F

V

L

M

E

D

H

G

G

V

I

V

V

D

D

L

I

G

G

I

F

I

V

G

G

E

K

N

D

V

T

L

L

E

D

E

E

E

N

L

D

L

F

N

D

R

D

R

-

A

-

Q

-