SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing 16417 FitnessBrowser__Keio:16417 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

P02911 Lysine/arginine/ornithine-binding periplasmic protein; LAO-binding protein from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 4 papers)
91% identity, 100% coverage: 1:260/260 of query aligns to 1:260/260 of P02911

query
sites
P02911

M

M

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D33 (= D33) binding L-arginine; binding L-lysine; binding L-ornithine; mutation to A: Decreases arginine and histidine binding affinity.
Y36 (= Y36) mutation to A: Shows a drastic decrease in arginine and histidine binding affinity.
D52 (= D52) mutation to A: Shows a drastic decrease in arginine and histidine binding affinity.
C60 (= C60) modified: Disulfide link with 67
C67 (= C67) modified: Disulfide link with 60
F74 (= F74) mutation to A: Shows a drastic decrease in arginine and histidine binding affinity.
S91 (= S91) binding L-arginine; binding L-ornithine; mutation to A: Has no effect on the arginine and histidine binding affinity.
S92 (= S92) binding L-arginine; binding L-lysine; binding L-ornithine; mutation to A: Decreases arginine and histidine binding affinity.
S94 (= S94) binding L-arginine; binding L-lysine; binding L-ornithine; mutation to A: Decreases arginine and histidine binding affinity.
R99 (= R99) binding L-arginine; binding L-lysine; binding L-ornithine; mutation to A: Shows a drastic decrease in arginine and histidine binding affinity.
L139 (= L139) mutation to K: Changes ligand specificity. Can bind glutamine. Still able to bind basic amino acids, however, with 1000-fold less affinity for arginine.; mutation to Q: Does not affect ligand preference.
T143 (= T143) binding L-arginine; binding L-lysine; binding L-ornithine
D183 (= D183) binding L-arginine; binding L-ornithine; mutation to A: Shows a drastic decrease in arginine and histidine binding affinity.

1lstA Three-dimensional structures of the periplasmic lysine-, arginine-, ornithine-binding protein with and without a ligand (see paper)
93% identity, 92% coverage: 23:260/260 of query aligns to 1:238/238 of 1lstA

query
sites
1lstA

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binding lysine: Y14 (= Y36), F52 (= F74), S70 (= S92), S72 (= S94), R77 (= R99), L117 (= L139), S120 (= S142), T121 (= T143), Q122 (= Q144), D161 (= D183)

1lahE Structural bases for multiple ligand specificity of the periplasmic lysine-, arginine-, ornithine-binding protein (see paper)
93% identity, 92% coverage: 23:260/260 of query aligns to 1:238/238 of 1lahE

query
sites
1lahE

A

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binding L-ornithine: Y14 (= Y36), F52 (= F74), S70 (= S92), S72 (= S94), R77 (= R99), S120 (= S142), Q122 (= Q144), D161 (= D183)

1lagE Structural bases for multiple ligand specificity of the periplasmic lysine-, arginine-, ornithine-binding protein (see paper)
93% identity, 92% coverage: 23:260/260 of query aligns to 1:238/238 of 1lagE

query
sites
1lagE

A

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D

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D

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D

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F

N

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Y

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D

D

binding histidine: Y14 (= Y36), F52 (= F74), S69 (= S91), S70 (= S92), L71 (= L93), S72 (= S94), R77 (= R99), L117 (= L139), S120 (= S142), Q122 (= Q144), D161 (= D183)

1lafE Structural bases for multiple ligand specificity of the periplasmic lysine-, arginine-, ornithine-binding protein (see paper)
93% identity, 92% coverage: 23:260/260 of query aligns to 1:238/238 of 1lafE

query
sites
1lafE

A

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D

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Q

D

D

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Y

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D

D

K

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M

A

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K

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Y

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D

F

F

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N

V

V

Y

Y

G

G

D

D

binding arginine: D11 (= D33), Y14 (= Y36), F52 (= F74), S69 (= S91), S70 (= S92), S72 (= S94), R77 (= R99), L117 (= L139), S120 (= S142), T121 (= T143), Q122 (= Q144), D161 (= D183)

5owfA Structure of a lao-binding protein mutant with glutamine (see paper)
93% identity, 90% coverage: 26:260/260 of query aligns to 1:235/235 of 5owfA

query
sites
5owfA

E

Q

T

T

V

V

R

R

I

I

G

G

T

T

D

D

T

T

Y
|
Y

A

A

P

P

F

F

S

S

K

K

D

D

A

A

K

K

G

G

D

E

F

F

V

I

G

G

F

F

D

D

I

I

D

D

L

L

G

G

N

N

E

E

M

M

C

C

K

K

R

R

M

M

Q

Q

V

V

K

K

C

C

T

T

W

W

V

V

A

A

S

S

D

D

F
|
F

D

D

A

A

L

L

I

I

P

P

S

S

L

L

K

K

A

A

K

K

I

I

D

D

A

A

I

I

S
|
S

L

L

S
|
S

I

I

T

T

D

D

K

K

R
|
R

Q

Q

E

E

I

I

A

A

F

F

S

S

D

D

K

K

L

L

Y

Y

A

A

D

D

S

S

R

R

L

L

I

I

A

A

K

K

G

G

S

S

P

P

I

I

Q

Q

P

P

T

T

L

L

D

E

S

S

L

L

K

K

G

G

K

K

H

H

V

V

G

G

V

V

L
x
K

Q

Q

G

G

S
|
S

T
|
T

Q

Q

E

E

A

A

Y

Y

A

A

N

N

E

D

T

N

W

W

R

R

S

T

K

K

G

G

V

V

D

D

V

V

A

A

Y

Y

A

A

N

N

Q

Q

D

D

L

L

V

I

Y

Y

S

S

D

D

L

L

A

T

A

A

G

G

R

R

L

L

D

D

A

A

L

L

Q

Q

D
|
D

E

E

V

V

A

A

S

S

E

E

G

G

F

F

L

L

K

K

Q

Q

P

P

A

A

G

G

K

K

D

E

F

Y

A

A

F

F

A

A

G

G

S

P

S

S

V

V

K

K

D

D

K

K

Y

Y

F

F

G

G

D

D

G

G

T

T

G

G

V

V

G

G

L

L

R

R

K

K

D

D

A

T

E

E

L

L

T

K

A

A

F

F

N

D

K

K

A

A

L

L

G

T

E

E

L

L

R

R

Q

Q

D

D

G

G

T

T

Y

Y

D

D

K

K

M

M

A

A

K

K

Y

Y

F

F

D

D

F

F

N

N

V

V

Y

Y

G

G

D

D

binding glutamine: Y11 (= Y36), F49 (= F74), S66 (= S91), S67 (= S92), S69 (= S94), R74 (= R99), K114 (≠ L139), S117 (= S142), T118 (= T143), D158 (= D183)

P0AEU0 Histidine-binding periplasmic protein; HBP from Escherichia coli (strain K12) (see 3 papers)
69% identity, 91% coverage: 24:259/260 of query aligns to 24:259/260 of P0AEU0

query
sites
P0AEU0

L

I

P

P

E

Q

T

N

V

I

R

R

I

I

G

G

T

T

D

D

T

P

T

T

Y

Y

A

A

P

P

F

F

S

E

S

S

K

K

D

N

A

S

K

Q

G

G

D

E

F

L

V

V

G

G

F

F

D

D

I

I

D

D

L

L

G

A

N

K

E

E

M

L

C
|
C

K

K

R

R

M

I

Q

N

V

T

K

Q

C
|
C

T

T

W

F

V

V

A

E

S

N

D

P

F

L

D

D

A

A

L

L

I

I

P

P

S

S

L

L

K

K

A

A

K

K

I

I

D

D

A

A

I

I

I

M

S
|
S

L

L

S
|
S

I

I

T

T

D

E

K

K

R
|
R

Q

Q

E

E

I

I

A

A

F

F

S

T

D

D

K

K

L

L

Y

Y

A

A

D

D

S

S

R

R

L

L

I

V

A

V

A

A

K

K

G

N

S

S

P

D

I

I

Q

Q

P

P

T

T

L

V

D

E

S

S

L

L

K

K

G

G

K

K

H

R

V

V

G

G

V

V

L

L

Q

Q

G

G

S

T

T
|
T

Q

Q

E

E

A

T

Y

F

A

G

N

N

E

E

T

H

W

W

R

A

S

P

K

K

G

G

V

I

D

E

V

I

V

V

A

S

Y

Y

A

Q

N

G

Q

Q

D

D

L

N

V

I

Y

Y

S

S

D

D

L

L

A

T

A

A

G

G

R

R

L

I

D

D

A

A

L

F

Q

Q

D
|
D

E

E

V

V

A

A

S

S

E

E

G

G

F

F

L

L

K

K

Q

Q

P

P

A

V

G

G

K

K

D

D

F

Y

A

K

F

F

A

G

G

G

S

P

S

S

V

V

K

K

D

D

K

E

K

K

Y

L

F

F

G

G

D

V

G

G

T

T

G

G

V

M

G

G

L

L

R

R

K

K

D

E

D

D

A

N

E

E

L

L

T

R

A

E

A

A

F

L

N

N

K

K

A

A

L

F

G

A

E

E

L

M

R

R

Q

A

D

D

G

G

T

T

Y

Y

D

E

K

K

M

L

A

A

K

K

Y

Y

F

F

D

D

F

F

N

D

V

V

Y

Y

G

G

C60 (= C60) modified: Disulfide link with 67
C67 (= C67) modified: Disulfide link with 60
S91 (= S91) binding L-histidine
S92 (= S92) binding L-histidine
S94 (= S94) binding L-histidine
R99 (= R99) binding L-histidine
T143 (= T143) binding L-histidine
D183 (= D183) binding L-histidine

Sites not aligning to the query:

1:22 signal peptide

1hslA Refined 1.89 angstroms structure of the histidine-binding protein complexed with histidine and its relationship with many other active transport(slash)chemosensory receptors (see paper)
70% identity, 91% coverage: 23:259/260 of query aligns to 1:237/238 of 1hslA

query
sites
1hslA

A

A

L

I

P

P

E

Q

T

K

V

I

R

R

I

I

G

G

T

T

D

D

T

P

T

T

Y
|
Y

A

A

P

P

F

F

S

E

S

S

K

K

D

N

A

A

K

Q

G

G

D

E

F

L

V

V

G

G

F

F

D

D

I

I

D

D

L

L

G

A

N

K

E

E

M

L

C

C

K

K

R

R

M

I

Q

N

V

T

K

Q

C

C

T

T

W

F

V

V

A

E

S

N

D

P

F
x
L

D

D

A

A

L

L

I

I

P

P

S

S

L

L

K

K

A

A

K

K

I

I

D

D

A

A

I

I

I

M

S
|
S

L
|
L

S
|
S

I

I

T

T

D

E

K

K

R
|
R

Q

Q

E

E

I

I

A

A

F

F

S

T

D

D

K

K

L

L

Y

Y

A

A

D

D

S

S

R

R

L

L

I

V

A

V

A

A

K

K

G

N

S

S

P

D

I

I

Q

Q

P

P

T

T

L

V

D

A

S

S

L

L

K

K

G

G

K

K

H

R

V

V

G

G

V

V

L

L

Q

Q

G

G

S
x
T

T
|
T

Q

Q

E

E

A

T

Y

F

A

G

N

N

E

E

T

H

W

W

R

A

S

P

K

K

G

G

V

I

D

E

V

I

V

V

A

S

Y

Y

A

Q

N

G

Q

Q

D

D

L

N

V

I

Y

Y

S

S

D

D

L

L

A

T

A

A

G

G

R

R

L

I

D

D

A

A

L

F

Q

Q

D
|
D

E

E

V

V

A

A

S

S

E

E

G

G

F

F

L

L

K

K

Q

Q

P

P

A

V

G

G

K

K

D

D

F

Y

A

K

F

F

A

G

G

G

S

P

S

A

V

V

K

K

D

D

K

E

K

K

Y

L

F

F

G

G

D

V

G

G

T

T

G

G

V

M

G

G

L

L

R

R

K

K

D

E

D

D

A

N

E

E

L

L

T

R

A

E

A

A

F

L

N

N

K

K

A

A

L

F

G

A

E

E

L

M

R

R

Q

A

D

D

G

G

T

T

Y

Y

D

E

K

K

M

L

A

A

K

K

Y

Y

F

F

D

D

F

F

N

D

V

V

Y

Y

G

G

binding histidine: Y14 (= Y36), L52 (≠ F74), S69 (= S91), S70 (= S92), L71 (= L93), S72 (= S94), R77 (= R99), T120 (≠ S142), T121 (= T143), D161 (= D183)

P02910 Histidine-binding periplasmic protein; HBP from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 2 papers)
69% identity, 91% coverage: 24:259/260 of query aligns to 24:259/260 of P02910

query
sites
P02910

L

I

P

P

E

Q

T

K

V

I

R

R

I

I

G

G

T

T

D

D

T

P

T

T

Y

Y

A

A

P

P

F

F

S
x
E

S

S

K
|
K

D

N

A

A

K

Q

G

G

D
x
E

F

L

V

V

G

G

F

F

D

D

I

I

D

D

L

L

G

A

N

K

E

E

M

L

C

C

K

K

R

R

M

I

Q

N

V

T

K

Q

C

C

T

T

W

F

V

V

A

E

S

N

D

P

F

L

D

D

A

A

L

L

I

I

P

P

S

S

L

L

K

K

A

A

K

K

I

I

D

D

A

A

I

I

I

M

S

S

L

L

S

S

I

I

T

T

D

E

K

K

R

R

Q

Q

E

E

I

I

A

A

F

F

S

T

D

D

K

K

L

L

Y

Y

A

A

D

D

S

S

R

R

L

L

I

V

A

V

A

A

K

K

G

N

S

S

P

D

I

I

Q

Q

P

P

T

T

L

V

D

A

S

S

L

L

K

K

G

G

K

K

H

R

V

V

G

G

V

V

L

L

Q

Q

G

G

S

T

T

T

Q

Q

E

E

A

T

Y

F

A

G

N

N

E

E

T

H

W

W

R

A

S

P

K

K

G

G

V

I

D

E

V

I

V

V

A

S

Y

Y

A

Q

N

G

Q

Q

D

D

L

N

V

I

Y

Y

S

S

D
|
D

L

L

A

T

A

A

G

G

R
|
R

L

I

D
|
D

A

A

L

F

Q

Q

D

D

E

E

V

V

A

A

S

S

E

E

G

G

F

F

L

L

K

K

Q

Q

P

P

A

V

G

G

K

K

D

D

F

Y

A

K

F

F

A

G

G

G

S

P

S

A

V

V

K

K

D

D

K

E

K

K

Y

L

F

F

G

G

D

V

G

G

T

T

G

G

V

M

G

G

L

L

R

R

K

K

D

E

D

D

A

N

E

E

L

L

T

R

A

E

A

A

F

L

N

N

K

K

A

A

L

F

G

A

E

E

L

M

R

R

Q

A

D

D

G

G

T

T

Y

Y

D

E

K

K

M

L

A

A

K

K

Y

Y

F

F

D

D

F

F

N

D

V

V

Y

Y

G

G

E40 (≠ S40) mutation to K: Decrease in ATPase-inducing activity and histidine transport; when associated with K-47.
K42 (= K42) mutation to E: Increases ATPase-inducing activity and histidine transport; when associated with K-47.
E47 (≠ D47) mutation to K: Decrease in ATPase-inducing activity and histidine transport; when associated with K-40. Increases ATPase-inducing activity and histidine transport; when associated with E-42.
D171 (= D171) mutation D->A,N: Strong decrease in ATPase-inducing activity and histidine transport.
R176 (= R176) mutation R->D,S: Strong decrease in ATPase-inducing activity and histidine transport.
D178 (= D178) mutation to A: Slight decrease in ATPase-inducing activity and histidine transport.

Sites not aligning to the query:

1:22 signal peptide

4zv1A An ancestral arginine-binding protein bound to arginine (see paper)
37% identity, 87% coverage: 27:253/260 of query aligns to 5:225/226 of 4zv1A

query
sites
4zv1A

T

T

V

L

R

R

I

V

G

G

T

T

D
x
E

T

A

T

T

Y
x
F

A

P

P

P

F

F

S

G

S

F

K

K

D

D

A

E

K

N

G

G

D

K

F

L

V

V

G

G

F

F

D

D

I

I

D

D

L

L

G

A

N

K

E

A

M

I

C

A

K

K

R

K

M

L

Q

G

V

V

K

K

C

V

T

E

W

F

V

K

A

P

S

M

D

D

F
|
F

D

D

A

G

L

I

I

I

P

P

S

A

L

L

K

Q

A

S

K

G

K

K

I

I

D

D

A

V

I

V

I

I

S
x
A

S
x
G

L
x
M

S
x
T

I

I

T

T

D

E

K

E

R
|
R

Q

K

E

Q

I

V

A

D

F

F

S

S

D

D

K

P

L

Y

Y

F

A

E

A

A

D

G

S

Q

R

A

L

I

I

V

A

V

A

K

K

K

G

G

S

N

P

D

I

S

Q

I

P

K

T

S

L

L

D

E

S

D

L

L

K

K

G

G

K

K

H

K

V

V

G

G

V

V

L
x
Q

Q

L

G

G

S
|
S

T
|
T

Q

S

E

E

A

Q

Y

H

A

V

N

K

E

K

T

V

W

A

R

K

S

D

K

A

G

G

V

V

D

K

V

V

V

K

A

K

Y

F

A

D

N

N

Q

F

D

S

L

E

V

A

Y

F

S

Q

D

E

L

L

A

K

A

S

G

G

R

R

L

V

D

D

A

A

A

V

L

V

Q

T

D
|
D

E

N

V

-

A

A

A

V

S

A

E

L

G

A

F

Y

L

V

K

K

Q

Q

P

N

A

P

G

N

K

-

D

-

F

-

A

-

F

-

A

A

G

G

S

V

S

K

V

I

K

V

D

G

K

E

K

T

Y

F

F

S

G

G

D

E

G

P

T

Y

G

G

V

I

G

A

L

V

R

R

K

K

D

G

D

N

A

S

E

E

L

L

T

L

A

E

A

K

F

I

N

N

K

K

A

A

L

L

G

E

E

E

L

M

R

K

Q

K

D

D

G

G

T

T

Y

Y

D

D

K

K

M

I

A

Y

K

E

K

K

Y

W

F

F

binding arginine: E11 (≠ D33), F14 (≠ Y36), F52 (= F74), A69 (≠ S91), G70 (≠ S92), M71 (≠ L93), T72 (≠ S94), R77 (= R99), Q117 (≠ L139), S120 (= S142), T121 (= T143), D161 (= D183)

4zv2A An ancestral arginine-binding protein bound to glutamine (see paper)
37% identity, 87% coverage: 27:253/260 of query aligns to 5:223/225 of 4zv2A

query
sites
4zv2A

T

T

V

L

R

R

I

V

G

G

T

T

D
x
E

T

A

T

T

Y
x
F

A

P

P

P

F

F

S

G

S

F

K

K

D

D

A

E

K

N

G

G

D

K

F

L

V

V

G

G

F

F

D

D

I

I

D

D

L

L

G

A

N

K

E

A

M

I

C

A

K

K

R

K

M

L

Q

G

V

V

K

K

C

V

T

E

W

F

V

K

A

P

S

M

D

D

F
|
F

D

D

A

G

L

I

I

I

P

P

S

A

L

L

K

Q

A

S

K

G

K

K

I

I

D

D

A

V

I

V

I

I

S

A

S
x
G

L
x
M

S
x
T

I

I

T

T

D

E

K

E

R
|
R

Q

K

E

Q

I

V

A

D

F

F

S

S

D

D

K

P

L

Y

Y

F

A

E

A

A

D

G

S

Q

R

A

L

I

I

V

A

V

A

K

K

K

G

G

S

N

P

D

I

S

Q

I

P

K

T

S

L

L

D

E

S

D

L

L

K

K

G

G

K

K

H

K

V

V

G

G

V

V

L

Q

Q

L

G

G

S
|
S

T
|
T

Q

S

E

E

A

Q

Y

H

A

V

N

K

E

K

T

V

W

-

R

-

S

A

K

A

G

G

V

V

D

K

V

V

V

K

A

K

Y

F

A

D

N

N

Q

F

D

S

L

E

V

A

Y

F

S

Q

D

E

L

L

A

K

A

S

G

G

R

R

L

V

D

D

A

A

A

V

L

V

Q

T

D
|
D

E

N

V

-

A

A

A

V

S

A

E

L

G

A

F

Y

L

V

K

K

Q

Q

P

N

A

P

G

N

K

-

D

-

F

-

A

-

F

-

A

A

G

G

S

V

S

K

V

I

K

V

D

G

K

E

K

T

Y

F

F

S

G

G

D

E

G

P

T

Y

G

G

V

I

G

A

L

V

R

R

K

K

D

G

D

N

A

S

E

E

L

L

T

L

A

E

A

K

F

I

N

N

K

K

A

A

L

L

G

E

E

E

L

M

R

K

Q

K

D

D

G

G

T

T

Y

Y

D

D

K

K

M

I

A

Y

K

E

K

K

Y

W

F

F

binding glutamine: E11 (≠ D33), F14 (≠ Y36), F52 (= F74), G70 (≠ S92), M71 (≠ L93), T72 (≠ S94), R77 (= R99), S120 (= S142), T121 (= T143), D159 (= D183)

2y7iA Structural basis for high arginine specificity in salmonella typhimurium periplasmic binding protein stm4351. (see paper)
36% identity, 87% coverage: 27:253/260 of query aligns to 7:227/228 of 2y7iA

query
sites
2y7iA

T

T

V

L

R
x
H

I

F

G

G

T

T

D

S

T

A

T

T

Y
|
Y

A

A

P

P

F

Y

S
x
E

S

F

K

V

D
|
D

A

A

K
x
D

G

N

D

K

F

I

V

V

G

G

F

F

D

D

I

I

D

D

L

V

G

A

N

N

E

A

M

V

C

C

K

K

R

E

M

M

Q

Q

V

A

K

E

C

C

T

S

W

F

V

T

A

N

S

Q

D

S

F
|
F

D
|
D

A

S

L

L

I

I

P

P

S

S

L

L

K

R

A

F

K

K

I

F

D
|
D

A

A

I

V

I

I

S
x
A

S
x
G

L

M

S
x
D

I

M

T

T

D

P

K

K

R
|
R

Q

E

Q

Q

E

Q

I

V

A

S

F

F

S

S

D

Q

K

P

L

Y

Y

Y

A

E

A

G

D

L

S

S

R

A

L

V

I

V

A

V

A

T

K

R

G

K

S

G

P

A

I

Y

Q

H

P

-

T

T

L

F

D

A

S

D

L

L

K

K

G

G

K

K

H

K

V

V

G

G

V

L

L
x
E

Q

N

G

G

S
x
T

T
|
T

Q

H

E

Q

A

R

Y

Y

A

L

N

Q

E

D

T

-

W

-

R

K

S

Q

K

Q

G

A

V

I

D

T

V

P

V

V

A

A

Y

Y

A
x
D

N

S

Q

Y

D

L

L

N

V

A

Y

F

S

T

D

D

L

L

A

K

A

N

G

N

R

R

L

L

D

E

A

G

A

V

L

F

Q

G

D
|
D

E

-

V

V

A

A

S

I

E

G

G

K

F

W

L

L

K

K

Q

N

P

-

A

-

G

N

K

P

D

D

F

Y

A

A

F

I

A

M

G

D

S

E

S

R

V

A

K

S

D

D

K

P

K

D

Y

Y

F

Y

G

G

D

K

G

G

T

L

G

G

V

I

G

A

L

V

R

R

K

K

D

D

D

N

A

D

E

A

L

L

T

L

A

Q

A

E

F

I

N

N

K

A

A

A

L

L

G

D

E

K

L

V

R

K

Q

A

D

S

G

P

T

E

Y

Y

D

A

K

Q

M

M

A

Q

K

E

K

K

Y

W

F

F

binding arginine: Y16 (= Y36), E20 (≠ S40), F54 (= F74), A71 (≠ S91), G72 (≠ S92), D74 (≠ S94), R79 (= R99), E118 (≠ L139), T121 (≠ S142), T122 (= T143), D160 (= D183)
binding zinc ion: H9 (≠ R29), D23 (= D43), D25 (≠ K45), D55 (= D75), D67 (= D87), D140 (≠ A163)

5itoA Structure of the periplasmic binding protein m117n-noct from a. Tumefaciens in complex with octopine (see paper)
35% identity, 89% coverage: 26:256/260 of query aligns to 3:252/255 of 5itoA

query
sites
5itoA

E

K

T

S

V

I

R

T

I

I

G

A

T

T

D
x
E

T

G

T

S

Y
|
Y

A

A

P

P

F

Y

S

N

S

F

K

K

D

D

A

A

K

G

G

G

D

K

F

L

V

I

G

G

F

F

D

D

I

I

D

D

L

L

G

G

N

N

E

D

M

L

C

C

K

K

R

R

M

M

Q

N

V

I

K

E

C

C

T

K

W

F

V

V

A

E

S

Q

D

A

F
x
W

D

D

A

G

L

I

I

I

P

P

S

S

L

L

K

T

A

A

K

G

K

R

I

Y

D

D

A

A

I

I

I

M

S
x
A

L

M

S
x
G

I

I

T

Q

D

P

K

A

R
|
R

Q

E

Q

K

E

V

I

I

A

A

F

F

S

S

D

R

K

P

L

Y

Y

L

A

L

A

T

D

P

S

N

R

T

L

F

I

L

A

T

K

A

G

D

S

S

P

P

I

L

Q

L

P

K

T

T

-

Q

-

V

-

A

-

I

-

E

-

N

-

L

-

P

L

L

D

D

S

N

L

I

-

T

-

P

-

E

-

Q

-

K

-

A

-

E

-

L

-

D

-

K

-

F

-

T

-

K

-

I

-

F

K

E

G

G

K

V

H

K

V

F

G

G

V

V

L
x
Q

Q

A

G

G

S
x
T

T
x
S

Q
x
H

E

E

A

A

Y

F

A

M

N

K

E

Q

T

M

W

M

R

P

S

S

K

-

G

-

V

V

D

Q

V

I

V

S

A

T

Y

Y

A

D

N

T

Q

I

D

D

L

N

V

V

Y

V

S

M

D

D

L

L

A

K

A

A

G

G

R

R

L

I

D

D

A

A

A

S

L

L

Q

-

D

-

E

-

V

-

A

-

A

A

S
|
S

E

V

G

S

F

F

L

L

K

K

-

P

-

L

-

T

-

D

Q

K

P

P

A

D

G

N

K

K

D

D

F

L

A

K

F

M

A

F

G

G

S

P

S

R

V

M

K

T

D

G

K

-

K

G

Y

L

F

F

G

G

D

K

G

G

T

V

G

G

V

V

G

G

L

I

R

R

K

K

D

E

D

D

A

A

E

D

L

L

T

K

A

A

A

L

F

F

N

D

K

K

A

A

L

I

G

D

E

A

L

A

R

I

Q

A

D

D

G

G

T

T

Y

V

D

Q

K

K

M

L

A

S

K

Q

Y

W

F

F

D

G

F

Y

N

D

binding octopine: E10 (≠ D33), Y13 (= Y36), W51 (≠ F74), A68 (≠ S91), A69 (≠ S92), G71 (≠ S94), R76 (= R99), Q139 (≠ L139), T142 (≠ S142), S143 (≠ T143), H144 (≠ Q144), S181 (= S188)

5otaA Structure of the periplasmic binding protein (pbp) noct from agrobacterium tumefaciens c58 in complex with octopinic acid (see paper)
36% identity, 89% coverage: 26:256/260 of query aligns to 2:251/254 of 5otaA

query
sites
5otaA

E

K

T

S

V

I

R

T

I

I

G

A

T

T

D
x
E

T

G

T

S

Y
|
Y

A

A

P

P

F

Y

S

N

S

F

K

K

D

D

A

A

K

G

G

G

D

K

F

L

V

I

G

G

F

F

D

D

I

I

D

D

L

L

G

G

N

N

E

D

M

L

C

C

K

K

R

R

M

M

Q

N

V

I

K

E

C

C

T

K

W

F

V

V

A

E

S

Q

D

A

F
x
W

D

D

A

G

L

I

I

I

P

P

S

S

L

L

K

T

A

A

K

G

K

R

I

Y

D

D

A

A

I

I

I

M

S

A

S
x
A

L

M

S
x
G

I

I

T

Q

D

P

K

A

R
|
R

Q

E

Q

K

E

V

I

I

A

A

F

F

S

S

D

R

K

P

-

Y

-

L

-

T

-

P

-
x
M

-

T

-

F

L

L

Y

T

A

T

A

A

D

D

S

S

R

P

L

L

I

L

A

K

A

T

K

Q

G

V

S

A

P

I

I

E

Q

N

P

L

T

P

L

L

D

D

S

N

L

I

-

T

-

P

-

E

-

Q

-

K

-

A

-

E

-

L

-

D

-

K

-

F

-

T

-

K

-

I

-

F

K

E

G

G

K

V

H

K

V

F

G

G

V

V

L
x
Q

Q

A

G

G

S
x
T

T
x
S

Q
x
H

E

E

A

A

Y

F

A

M

N

K

E

Q

T

M

W

M

R

P

S

S

K

-

G

-

V

V

D

Q

V

I

V

S

A

T

Y

Y

A

D

N

T

Q

I

D

D

L

N

V

V

Y

V

S

M

D

D

L

L

A

K

A

A

G

G

R

R

L

I

D

D

A

A

A

S

L

L

Q

-

D

-

E

-

V

-

A

-

A

A

S
|
S

E

V

G

S

F

F

L

L

K

K

-

P

-

L

-

T

-

D

Q

K

P

P

A

D

G

N

K

K

D

D

F

L

A

K

F

M

A

F

G

G

S

P

S

R

V

M

K

T

D

G

K

-

K

G

Y

L

F

F

G

G

D

K

G

G

T

V

G

G

V

V

G

G

L

I

R

R

K

K

D

E

D

D

A

A

E

D

L

L

T

K

A

A

A

L

F

F

N

D

K

K

A

A

L

I

G

D

E

A

L

A

R

I

Q

A

D

D

G

G

T

T

Y

V

D

Q

K

K

M

L

A

S

K

Q

Y

W

F

F

D

G

F

Y

N

D

binding (2~{S})-5-azanyl-2-[[(2~{R})-1-oxidanyl-1-oxidanylidene-propan-2-yl]amino]pentanoic acid: E9 (≠ D33), Y12 (= Y36), W50 (≠ F74), A68 (≠ S92), G70 (≠ S94), R75 (= R99), M90 (vs. gap), Q138 (≠ L139), T141 (≠ S142), S142 (≠ T143), H143 (≠ Q144), S180 (= S188)

5ot9A Structure of the periplasmic binding protein (pbp) noct from a.Tumefaciens c58 in complex with histopine. (see paper)
36% identity, 89% coverage: 26:256/260 of query aligns to 2:251/254 of 5ot9A

query
sites
5ot9A

E

K

T

S

V

I

R

T

I

I

G

A

T

T

D
x
E

T

G

T

S

Y
|
Y

A

A

P

P

F

Y

S

N

S

F

K

K

D

D

A

A

K

G

G

G

D

K

F

L

V

I

G

G

F

F

D

D

I

I

D

D

L

L

G

G

N

N

E

D

M

L

C

C

K

K

R

R

M

M

Q

N

V

I

K

E

C

C

T

K

W

F

V

V

A

E

S

Q

D

A

F
x
W

D

D

A

G

L

I

I

I

P

P

S

S

L

L

K

T

A

A

K

G

K

R

I

Y

D

D

A

A

I

I

I

M

S
x
A

L

M

S

G

I

I

T

Q

D

P

K

A

R
|
R

Q

E

Q

K

E

V

I

I

A

A

F

F

S

S

D

R

K

P

-

Y

-

L

-

T

-

P

-
x
M

-

T

-

F

L

L

Y

T

A

T

A

A

D

D

S

S

R

P

L

L

I

L

A

K

A

T

K

Q

G

V

S

A

P

I

I

E

Q

N

P

L

T

P

L

L

D

D

S

N

L

I

-

T

-

P

-

E

-

Q

-

K

-

A

-

E

-

L

-

D

-

K

-

F

-

T

-

K

-

I

-

F

K

E

G

G

K

V

H

K

V

F

G

G

V

V

L
x
Q

Q

A

G

G

S
x
T

T
x
S

Q
x
H

E

E

A

A

Y

F

A

M

N

K

E

Q

T

M

W

M

R

P

S

S

K

-

G

-

V

V

D

Q

V

I

V

S

A

T

Y

Y

A

D

N

T

Q

I

D

D

L

N

V

V

Y

V

S

M

D

D

L

L

A

K

A

A

G

G

R

R

L

I

D

D

A

A

A

S

L

L

Q

-

D

-

E

-

V

-

A

-

A

A

S
|
S

E

V

G

S

F

F

L

L

K

K

-

P

-

L

-

T

-

D

Q

K

P

P

A

D

G

N

K

K

D

D

F

L

A

K

F

M

A

F

G

G

S

P

S

R

V

M

K

T

D

G

K

-

K

G

Y

L

F

F

G

G

D

K

G

G

T

V

G

G

V

V

G

G

L

I

R

R

K

K

D

E

D

D

A

A

E

D

L

L

T

K

A

A

A

L

F

F

N

D

K

K

A

A

L

I

G

D

E

A

L

A

R

I

Q

A

D

D

G

G

T

T

Y

V

D

Q

K

K

M

L

A

S

K

Q

Y

W

F

F

D

G

F

Y

N

D

binding Histopine: E9 (≠ D33), Y12 (= Y36), W50 (≠ F74), A67 (≠ S91), A68 (≠ S92), R75 (= R99), M90 (vs. gap), Q138 (≠ L139), T141 (≠ S142), S142 (≠ T143), H143 (≠ Q144), S180 (= S188)

4powA Structure of the pbp noct in complex with pyronopaline (see paper)
36% identity, 89% coverage: 26:256/260 of query aligns to 2:251/254 of 4powA

query
sites
4powA

E

K

T

S

V

I

R

T

I

I

G

A

T

T

D
x
E

T

G

T

S

Y
|
Y

A

A

P

P

F

Y

S

N

S

F

K

K

D

D

A

A

K

G

G

G

D

K

F

L

V

I

G

G

F

F

D

D

I

I

D

D

L

L

G

G

N

N

E

D

M

L

C

C

K

K

R

R

M

M

Q

N

V

I

K

E

C

C

T

K

W

F

V

V

A

E

S

Q

D

A

F
x
W

D

D

A

G

L

I

I

I

P

P

S

S

L

L

K

T

A

A

K

G

K

R

I

Y

D

D

A

A

I

I

I

M

S
x
A

L

M

S
x
G

I

I

T

Q

D

P

K

A

R
|
R

Q

E

Q

K

E

V

I

I

A

A

F

F

S

S

D

R

K

P

-

Y

-

L

-

T

-

P

-
x
M

-

T

-

F

L

L

Y

T

A

T

A

A

D

D

S

S

R

P

L

L

I

L

A

K

A

T

K

Q

G

V

S

A

P

I

I

E

Q

N

P

L

T

P

L

L

D

D

S

N

L

I

-

T

-

P

-

E

-

Q

-

K

-

A

-

E

-

L

-

D

-

K

-

F

-

T

-

K

-

I

-

F

K

E

G

G

K

V

H

K

V

F

G

G

V

V

L
x
Q

Q

A

G

G

S
x
T

T
x
S

Q
x
H

E

E

A

A

Y

F

A

M

N

K

E

Q

T

M

W

M

R

P

S

S

K

-

G

-

V

V

D

Q

V

I

V

S

A

T

Y

Y

A

D

N

T

Q

I

D

D

L

N

V

V

Y

V

S

M

D

D

L

L

A

K

A

A

G

G

R

R

L

I

D

D

A

A

A

S

L

L

Q

-

D

-

E

-

V

-

A

-

A

A

S
|
S

E

V

G

S

F

F

L

L

K

K

-

P

-

L

-

T

-

D

Q

K

P

P

A

D

G

N

K

K

D

D

F

L

A

K

F

M

A

F

G

G

S

P

S

R

V

M

K

T

D

G

K

-

K

G

Y

L

F

F

G

G

D

K

G

G

T

V

G

G

V

V

G

G

L

I

R

R

K

K

D

E

D

D

A

A

E

D

L

L

T

K

A

A

A

L

F

F

N

D

K

K

A

A

L

I

G

D

E

A

L

A

R

I

Q

A

D

D

G

G

T

T

Y

V

D

Q

K

K

M

L

A

S

K

Q

Y

W

F

F

D

G

F

Y

N

D

binding 1-[(1S)-4-carbamimidamido-1-carboxybutyl]-5-oxo-D-proline: E9 (≠ D33), Y12 (= Y36), W50 (≠ F74), A67 (≠ S91), A68 (≠ S92), G70 (≠ S94), R75 (= R99), M90 (vs. gap), Q138 (≠ L139), T141 (≠ S142), S142 (≠ T143), H143 (≠ Q144), S180 (= S188)

5otcA Structure of the periplasmic binding protein (pbp) noct from agrobacterium tumefaciens c58 in complex with noroctopinic acid. (see paper)
36% identity, 89% coverage: 26:256/260 of query aligns to 2:251/256 of 5otcA

query
sites
5otcA

E

K

T

S

V

I

R

T

I

I

G

A

T

T

D
x
E

T

G

T

S

Y
|
Y

A

A

P

P

F

Y

S

N

S

F

K

K

D

D

A

A

K

G

G

G

D

K

F

L

V

I

G

G

F

F

D

D

I

I

D

D

L

L

G

G

N

N

E

D

M

L

C

C

K

K

R

R

M

M

Q

N

V

I

K

E

C

C

T

K

W

F

V

V

A

E

S

Q

D

A

F
x
W

D

D

A

G

L

I

I

I

P

P

S

S

L

L

K

T

A

A

K

G

K

R

I

Y

D

D

A

A

I

I

I

M

S

A

S
x
A

L

M

S
x
G

I

I

T

Q

D

P

K

A

R
|
R

Q

E

Q

K

E

V

I

I

A

A

F

F

S

S

D

R

K

P

-

Y

-

L

-

T

-

P

-

M

-

T

-

F

L

L

Y

T

A

T

A

A

D

D

S

S

R

P

L

L

I

L

A

K

A

T

K

Q

G

V

S

A

P

I

I

E

Q

N

P

L

T

P

L

L

D

D

S

N

L

I

-

T

-

P

-

E

-

Q

-

K

-

A

-

E

-

L

-

D

-

K

-

F

-

T

-

K

-

I

-

F

K

E

G

G

K

V

H

K

V

F

G

G

V

V

L
x
Q

Q

A

G

G

S
x
T

T
x
S

Q
x
H

E

E

A

A

Y

F

A

M

N

K

E

Q

T

M

W

M

R

P

S

S

K

-

G

-

V

V

D

Q

V

I

V

S

A

T

Y

Y

A

D

N

T

Q

I

D

D

L

N

V

V

Y

V

S

M

D

D

L

L

A

K

A

A

G

G

R

R

L

I

D

D

A

A

A

S

L

L

Q

-

D

-

E

-

V

-

A

-

A

A

S
|
S

E

V

G

S

F

F

L

L

K

K

-

P

-

L

-

T

-

D

Q

K

P

P

A

D

G

N

K

K

D

D

F

L

A

K

F

M

A

F

G

G

S

P

S

R

V

M

K

T

D

G

K

-

K

G

Y

L

F

F

G

G

D

K

G

G

T

V

G

G

V

V

G

G

L

I

R

R

K

K

D

E

D

D

A

A

E

D

L

L

T

K

A

A

A

L

F

F

N

D

K

K

A

A

L

I

G

D

E

A

L

A

R

I

Q

A

D

D

G

G

T

T

Y

V

D

Q

K

K

M

L

A

S

K

Q

Y

W

F

F

D

G

F

Y

N

D

binding (2~{S})-5-azanyl-2-(2-hydroxy-2-oxoethylamino)pentanoic acid: E9 (≠ D33), Y12 (= Y36), W50 (≠ F74), A68 (≠ S92), G70 (≠ S94), R75 (= R99), Q138 (≠ L139), T141 (≠ S142), S142 (≠ T143), H143 (≠ Q144), S180 (= S188)

5ovzA High resolution structure of the pbp noct in complex with nopaline (see paper)
36% identity, 89% coverage: 26:256/260 of query aligns to 3:252/259 of 5ovzA

query
sites
5ovzA

E

K

T

S

V

I

R

T

I

I

G

A

T

T

D
x
E

T

G

T

S

Y
|
Y

A

A

P

P

F

Y

S

N

S

F

K

K

D

D

A

A

K

G

G

G

D

K

F

L

V

I

G

G

F

F

D

D

I

I

D

D

L

L

G

G

N

N

E

D

M

L

C

C

K

K

R

R

M

M

Q

N

V

I

K

E

C

C

T

K

W

F

V

V

A

E

S

Q

D

A

F
x
W

D

D

A

G

L

I

I

I

P

P

S

S

L

L

K

T

A

A

K

G

K

R

I

Y

D

D

A

A

I

I

I

M

S
x
A

L

M

S
x
G

I

I

T

Q

D

P

K

A

R
|
R

Q

E

Q

K

E

V

I

I

A

A

F

F

S

S

D

R

K

P

-

Y

-

L

-

T

-

P

-
x
M

-

T

-

F

L

L

Y

T

A

T

A

A

D

D

S

S

R

P

L

L

I

L

A

K

A

T

K

Q

G

V

S

A

P

I

I

E

Q

N

P

L

T

P

L

L

D

D

S

N

L

I

-

T

-

P

-

E

-

Q

-

K

-

A

-

E

-

L

-

D

-

K

-

F

-

T

-

K

-

I

-

F

K

E

G

G

K

V

H

K

V

F

G

G

V

V

L
x
Q

Q

A

G

G

S
x
T

T
x
S

Q
x
H

E

E

A

A

Y

F

A

M

N

K

E

Q

T

M

W

M

R

P

S

S

K

-

G

-

V

V

D

Q

V

I

V

S

A

T

Y

Y

A

D

N

T

Q

I

D

D

L

N

V

V

Y

V

S

M

D

D

L

L

A

K

A

A

G

G

R

R

L

I

D

D

A

A

A

S

L

L

Q

-

D

-

E

-

V

-

A

-

A

A

S
|
S

E

V

G

S

F

F

L

L

K

K

-

P

-

L

-

T

-

D

Q

K

P

P

A

D

G

N

K

K

D

D

F

L

A

K

F

M

A

F

G

G

S

P

S

R

V

M

K

T

D

G

K

-

K

G

Y

L

F

F

G

G

D

K

G

G

T
x
V

G

G

V

V

G

G

L

I

R

R

K

K

D

E

D

D

A

A

E

D

L

L

T

K

A

A

A

L

F

F

N

D

K

K

A

A

L

I

G

D

E

A

L

A

R

I

Q

A

D

D

G

G

T

T

Y

V

D

Q

K

K

M

L

A

S

K

Q

Y

W

F

F

D

G

F

Y

N

D

binding N-[(1S)-4-carbamimidamido-1-carboxybutyl]-D-glutamic acid: E10 (≠ D33), Y13 (= Y36), W51 (≠ F74), A68 (≠ S91), A69 (≠ S92), G71 (≠ S94), R76 (= R99), M91 (vs. gap), Q139 (≠ L139), T142 (≠ S142), S143 (≠ T143), H144 (≠ Q144), S181 (= S188), V213 (≠ T217)

8hqrA Crystal structure of the arginine-/lysine-binding protein sar11_1210 from 'candidatus pelagibacter ubique' htcc1062 bound to arginine (see paper)
34% identity, 88% coverage: 28:256/260 of query aligns to 10:264/267 of 8hqrA

query
sites
8hqrA

V

I

R

K

I

I

G

G

T

T

D
x
E

T

G

T

A

Y
|
Y

A

P

P

P

F

W

S

N

S

S

K

K

D

D

A

A

K

S

G

G

D

A

F

L

V

I

G

G

F

F

D

E

I

V

D

E

L

L

G

A

N

E

E

E

M

L

C

C

K

K

R

I

M

M

Q

G

V

R

K

E

C

C

T

T

W

I

V

V

A

E

S

Q

D

D

F
x
W

D

D

A

G

L

M

I

I

P

P

S

A

L

L

K

L

A

M

K

R

K

K

I

F

D

D

A

A

I

I

I

M

S
x
A

S
x
G

L

M

S
|
S

I

I

T

T

D

A

K

E

R
|
R

Q

Q

Q

K

E

T

I

I

A

T

F

F

S

S

D

Q

K

G

L

Y

Y

A

A

D

A
x
E

D

V

S

A

R

A

L

L

I

A

A

V

A

M

K

K

G

G

S

S

P

S

I

L

Q

E

P

-

T

S

L

M

D

D

S

T

L

P

K

E

G

G

K

I

H

N

V

L

G

-

V

T

L

L

Q

G

G

G

S

S

-

A

-

V

-

K

-

T

-

L

-

K

-

T

-

L

-

T

-

A

-

L

-

A

-

G

-

K

-

T

-

V

-

C

T

T

Q
|
Q

E

T

A

G

Y
x
T

A
x
I

N

H

E

Q

T

N

W

F

R

L

S

E

K

S

G

G

-

D

-

V

-

G

-

K

V

V

D

N

V

V

V

R

A

T

Y

Y

A

K

N

T

Q

Q

D

D

L

E

V

V

Y

N

S

L

D

D

L

L

A

T

A

S

G

G

R

R

L

C

D

D

A

V

A

A

L

L

Q

A

D

A

E

A

V

V

A

A

A

F

S

T

E

D

G

-

F

-

L

Y

K

A

Q

D

P

K

A

S

G

G

K

K

D

P

F

V

A

V

F

L

A

V

G

G

S

P

S

T

V

F

K

S

D

G

K

G

K

A

Y

-

F

F

G

G

D

N

G

G

T

V

G

G

V

V

G

G

L

I

R

R

K

Q

D

G

-

G

-

D

-

A

-

I

-

G

-

T

-

R

D

D

A

A

E

K

L

L

T

L

A

K

A

D

F

F

N

N

K

K

A

A

L

I

G

N

E

T

L

A

R

R

Q

K

D

Q

G

G

T

I

Y

I

D

S

K

K

M

L

A

A

K

I

K

K

Y

H

F

F

D

G

F

F

N

D

binding arginine: E15 (≠ D33), Y18 (= Y36), W56 (≠ F74), A73 (≠ S91), G74 (≠ S92), S76 (= S94), R81 (= R99), E94 (≠ A112), Q143 (= Q144), T146 (≠ Y147), I147 (≠ A148)

3tqlA Structure of the amino acid abc transporter, periplasmic amino acid- binding protein from coxiella burnetii. (see paper)
33% identity, 88% coverage: 26:253/260 of query aligns to 2:225/225 of 3tqlA

query
sites
3tqlA

E

D

T

T

V

I

R

K

I

F

G

A

T

T

D
x
E

T

A

T

T

Y
|
Y

A

P

P

P

F

Y

S

V

S

Y

K

-

D

-

A

M

K

G

G

G

D

Q

F

V

V

E

G

G

F

F

D

G

I

A

D

D

L

I

G

V

N

K

E

A

M

V

C

C

K

K

R

Q

M

M

Q

Q

V

A

K

V

C

C

T

T

W

I

V

S

A

N

S

Q

D

P

F
x
W

D

D

A

S

L

L

I

I

P

P

S

S

L

L

K

K

A

L

K

G

K

K

I

F

D

D

A

A

I

L

I

F

S
x
G

L

M

S
x
N

I

I

T

T

D

T

K

A

R
|
R

Q

Q

Q

K

E

E

I

V

A

D

F

F

S

T

D

D

K

P

L

Y

Y

Y

A

T

A

N

D

S

S

V

R
x
S

L

F

I

I

A

A

A

D

K

K

G

N

S

T

P

P

I

L

Q

T

P

L

T

S

L

K

D

Q

S

G

L

L

K

K

G

G

K

K

H

I

V

I

G

G

V

V

L

Q

Q

G

G

G

S

T

T

T

Q

F

E

D

A

S

Y

Y

A

L

N

Q

E

D

T

S

W

F

R

-

S

G

K

N

G

S

V

I

D

T

V

I

V

Q

A

R

Y

Y

A

P

N

S

Q

E

D

E

L

D

V

A

Y

L

S

M

D

D

L

L

A

T

A

S

G

G

R

R

L

V

D

D

A

A

A

V

L

V

Q

G

D

D

E

T

V

P

A

L

A

I

S

K

E

Q

G

-

F

W

L

L

K

K

Q

Q

P

N

A

G

G

R

K

R

D

E

F

Y

A

V

F

L

A

I

G

G

S

K

S

P

V

V

K

N

D

D

K

P

K

N

Y

Y

F

F

G

G

D

K

G

G

T

V

G

G

V

I

G

A

L

V

R

K

K

K

D

G

D

N

A

Q

E

A

L

L

T

L

A

L

A

K

F

L

N

N

K

K

A

A

L

L

G

A

E

A

L

I

R

K

Q

A

D

N

G

G

T

V

Y

Y

D

A

K

A

M

I

A

V

K

Q

K

K

Y

Y

F

F

binding arginine: E9 (≠ D33), Y12 (= Y36), W48 (≠ F74), G65 (≠ S91), G66 (≠ S92), N68 (≠ S94), R73 (= R99), S89 (≠ R115)

Query Sequence

>16417 FitnessBrowser__Keio:16417
MKKSILALSLLVGLSTAASSYAALPETVRIGTDTTYAPFSSKDAKGDFVGFDIDLGNEMC
KRMQVKCTWVASDFDALIPSLKAKKIDAIISSLSITDKRQQEIAFSDKLYAADSRLIAAK
GSPIQPTLDSLKGKHVGVLQGSTQEAYANETWRSKGVDVVAYANQDLVYSDLAAGRLDAA
LQDEVAASEGFLKQPAGKDFAFAGSSVKDKKYFGDGTGVGLRKDDAELTAAFNKALGELR
QDGTYDKMAKKYFDFNVYGD

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory