SitesBLAST
Comparing 16946 FitnessBrowser__Keio:16946 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
1rm6A Structure of 4-hydroxybenzoyl-coa reductase from thauera aromatica (see paper)
33% identity, 99% coverage: 3:744/752 of query aligns to 10:752/761 of 1rm6A
- active site: Q206 (= Q206), T241 (≠ Q241), Y318 (≠ A318), L322 (≠ K322), R350 (= R350), E718 (= E710), G719 (≠ P711)
- binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): G235 (= G235), G236 (= G236), F237 (= F237), G238 (= G238), R350 (= R350), I473 (= I474), G474 (= G475), Q475 (= Q476), G476 (= G477), Y513 (≠ F515), S514 (≠ A516), S515 (= S517), V517 (≠ Q519), T518 (≠ S520), L646 (= L636), N647 (= N637), V651 (≠ A641), Q654 (= Q644), K714 (= K706), E715 (≠ S707), A716 (≠ L708), S717 (≠ G709), E718 (= E710)
O33819 4-hydroxybenzoyl-CoA reductase subunit alpha; 4-HBCR subunit alpha; EC 1.1.7.1 from Thauera aromatica (see paper)
33% identity, 99% coverage: 3:744/752 of query aligns to 18:760/769 of O33819
1t3qB Crystal structure of quinoline 2-oxidoreductase from pseudomonas putida 86 (see paper)
30% identity, 99% coverage: 1:747/752 of query aligns to 19:783/786 of 1t3qB
- active site: Q224 (= Q206), A259 (≠ Q241), E336 (≠ A316), V343 (= V323), R371 (= R350), E743 (= E710), S744 (≠ P711)
- binding pterin cytosine dinucleotide: G254 (= G236), F255 (= F237), R371 (= R350), S506 (≠ I474), G507 (= G475), Q508 (= Q476), H510 (≠ A478), T513 (≠ V481), Y545 (≠ F515), S547 (= S517), G549 (≠ Q519), A550 (≠ S520), C666 (≠ S632), I670 (≠ L636), I674 (≠ L640), V675 (≠ A641), Q678 (= Q644), K739 (= K706), G740 (≠ S707), M741 (≠ L708), G742 (= G709)
P19913 Carbon monoxide dehydrogenase large chain; CO dehydrogenase subunit L; CO-DH L; EC 1.2.5.3 from Hydrogenophaga pseudoflava (Pseudomonas carboxydoflava) (see paper)
27% identity, 99% coverage: 1:746/752 of query aligns to 18:796/803 of P19913
- R384 (= R350) modified: 4-hydroxyarginine
1ffvB Carbon monoxide dehydrogenase from hydrogenophaga pseudoflava (see paper)
27% identity, 98% coverage: 9:746/752 of query aligns to 25:790/797 of 1ffvB
- active site: Q231 (= Q206), V266 (≠ Q241), P343 (≠ A318), I349 (≠ R329), R378 (= R350), C379 (vs. gap), E751 (= E710), S752 (≠ P711)
- binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): G260 (= G235), G261 (= G236), F262 (= F237), G263 (= G238), A376 (= A348), R378 (= R350), C379 (vs. gap), Q516 (≠ I474), G517 (= G475), Q518 (= Q476), H520 (≠ A478), T523 (≠ V481), Y556 (≠ F515), G557 (≠ A516), S558 (= S517), S560 (≠ Q519), T561 (≠ S520), C674 (≠ S632), I678 (≠ L636), I683 (≠ A641), Q686 (= Q644), K747 (= K706), G748 (≠ S707), V749 (≠ L708), A750 (≠ G709), E751 (= E710)
1ffuB Carbon monoxide dehydrogenase from hydrogenophaga pseudoflava which lacks the mo-pyranopterin moiety of the molybdenum cofactor (see paper)
27% identity, 98% coverage: 9:746/752 of query aligns to 25:790/797 of 1ffuB
- active site: Q231 (= Q206), V266 (≠ Q241), P343 (≠ A318), I349 (≠ R329), R378 (= R350), C379 (vs. gap), E751 (= E710), S752 (≠ P711)
- binding cytidine-5'-diphosphate: Q518 (= Q476), H520 (≠ A478), T523 (≠ V481), S558 (= S517), S560 (≠ Q519), T561 (≠ S520), C674 (≠ S632), T676 (≠ H634), I678 (≠ L636), I683 (≠ A641), K747 (= K706), G748 (≠ S707), V749 (≠ L708), A750 (≠ G709)
P77489 Aldehyde oxidoreductase molybdenum-binding subunit PaoC; EC 1.2.99.6 from Escherichia coli (strain K12) (see 2 papers)
29% identity, 99% coverage: 2:746/752 of query aligns to 24:728/732 of P77489
- GF 241:242 (= GF 236:237) binding
- R440 (≠ T442) mutation R->H,K: Decrease in catalytic efficiency.
- IGT 468:470 (≠ IGQ 474:476) binding
- GA 511:512 (≠ QS 519:520) binding
- 615:621 (vs. 634:640, 57% identical) binding
- Q625 (= Q644) binding
- KGVG 688:691 (≠ KSLG 706:709) binding
- E692 (= E710) mutation to Q: Loss of activity.
5g5gC Escherichia coli periplasmic aldehyde oxidase (see paper)
29% identity, 99% coverage: 2:746/752 of query aligns to 24:728/731 of 5g5gC
- active site: Q211 (= Q206), L246 (≠ Q241), P316 (≠ G306), Q322 (≠ G312), R350 (= R350), E692 (= E710), L693 (≠ P711)
- binding pterin cytosine dinucleotide: G240 (= G235), G241 (= G236), F242 (= F237), R350 (= R350), I468 (= I474), G469 (= G475), T470 (≠ Q476), G507 (≠ F515), Q509 (≠ S517), G511 (≠ Q519), A512 (≠ S520), L617 (= L636), N618 (= N637), T621 (≠ L640), Q625 (= Q644), K688 (= K706), V690 (≠ L708), G691 (= G709), E692 (= E710)
4zohA Crystal structure of glyceraldehyde oxidoreductase (see paper)
26% identity, 99% coverage: 2:742/752 of query aligns to 9:700/701 of 4zohA
- active site: Q186 (= Q206), I219 (≠ Q241), V298 (≠ G320), S300 (≠ K322), M304 (≠ L326), R332 (= R350), E668 (= E710), A669 (≠ P711)
- binding pterin cytosine dinucleotide: G213 (= G235), A214 (≠ G236), F215 (= F237), R332 (= R350), H442 (≠ I474), G443 (= G475), Q444 (= Q476), D446 (≠ A478), W482 (≠ F515), S484 (= S517), T486 (≠ Q519), V487 (≠ S520), I594 (≠ L636), N595 (= N637), L598 (= L640), Q602 (= Q644), K664 (= K706), G665 (≠ S707), I666 (≠ L708), G667 (= G709), E668 (= E710)
4usaA Aldehyde oxidoreductase from desulfovibrio gigas (mop), soaked with trans-cinnamaldehyde (see paper)
28% identity, 99% coverage: 2:744/752 of query aligns to 182:903/907 of 4usaA
- active site: I390 (≠ Q206), F425 (≠ Q241), R501 (≠ A318), F505 (≠ K322), R533 (= R350), E869 (= E710), L870 (≠ P711)
- binding bicarbonate ion: R460 (= R277), A531 (= A348), F532 (≠ M349), Y535 (= Y352), Q539 (= Q356)
- binding hydrocinnamic acid: I255 (≠ W74), F425 (≠ Q241), F494 (≠ H311), L497 (≠ S314), Y535 (= Y352), L626 (≠ T445)
- binding magnesium ion: E899 (≠ K740), E903 (= E744)
- binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): T420 (≠ G236), F421 (= F237), G422 (= G238), R533 (= R350), W650 (≠ A471), H653 (≠ I474), G654 (= G475), Q655 (= Q476), G656 (= G477), S695 (≠ A514), G696 (≠ F515), G697 (≠ A516), Q700 (= Q519), Q701 (≠ S520), C799 (≠ L636), N800 (= N637), T804 (≠ A641), Q807 (= Q644), S865 (≠ K706), G866 (≠ S707), V867 (≠ L708), G868 (= G709), E869 (= E710)
Sites not aligning to the query:
- binding fe2/s2 (inorganic) cluster: 38, 40, 41, 43, 45, 46, 48, 58, 60, 100, 101, 103, 137, 139
- binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 99, 139
4us9A Aldehyde oxidoreductase from desulfovibrio gigas (mop), soaked with 3- phenylpropionaldehyde (see paper)
28% identity, 99% coverage: 2:744/752 of query aligns to 182:903/907 of 4us9A
- active site: I390 (≠ Q206), F425 (≠ Q241), R501 (≠ A318), F505 (≠ K322), R533 (= R350), E869 (= E710), L870 (≠ P711)
- binding 3-phenylpropanal: I255 (≠ W74), F257 (≠ L76), P258 (≠ D77), H752 (≠ F609)
- binding bicarbonate ion: R460 (= R277), L498 (≠ I315), A531 (= A348), F532 (≠ M349), Y535 (= Y352), Q539 (= Q356), R890 (≠ A731), Y892 (≠ N733)
- binding magnesium ion: E899 (≠ K740), E903 (= E744)
- binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): T420 (≠ G236), F421 (= F237), G422 (= G238), R533 (= R350), W650 (≠ A471), H653 (≠ I474), G654 (= G475), Q655 (= Q476), G656 (= G477), S695 (≠ A514), G696 (≠ F515), G697 (≠ A516), Q700 (= Q519), Q701 (≠ S520), C799 (≠ L636), N800 (= N637), T804 (≠ A641), Q807 (= Q644), S865 (≠ K706), G866 (≠ S707), V867 (≠ L708), G868 (= G709), E869 (= E710)
Sites not aligning to the query:
- binding fe2/s2 (inorganic) cluster: 38, 40, 41, 43, 45, 46, 48, 58, 60, 100, 101, 103, 137, 139
- binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 99, 139
4us8A Aldehyde oxidoreductase from desulfovibrio gigas (mop), soaked with benzaldehyde (see paper)
28% identity, 99% coverage: 2:744/752 of query aligns to 182:903/907 of 4us8A
- active site: I390 (≠ Q206), F425 (≠ Q241), R501 (≠ A318), F505 (≠ K322), R533 (= R350), E869 (= E710), L870 (≠ P711)
- binding bicarbonate ion: R460 (= R277), L498 (≠ I315), A531 (= A348), F532 (≠ M349), Y535 (= Y352), Q539 (= Q356)
- binding benzaldehyde: I255 (≠ W74), I255 (≠ W74), L394 (≠ I210), F425 (≠ Q241), F425 (≠ Q241), F425 (≠ Q241), F425 (≠ Q241), L497 (≠ S314), L497 (≠ S314), R501 (≠ A318), A531 (= A348), Y535 (= Y352), Y535 (= Y352), L626 (≠ T445), L626 (≠ T445), L626 (≠ T445), P694 (≠ G513), G696 (≠ F515), G697 (≠ A516)
- binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): T420 (≠ G236), F421 (= F237), G422 (= G238), R533 (= R350), H653 (≠ I474), G654 (= G475), Q655 (= Q476), G656 (= G477), S695 (≠ A514), G696 (≠ F515), G697 (≠ A516), Q700 (= Q519), Q701 (≠ S520), C799 (≠ L636), N800 (= N637), T804 (≠ A641), Q807 (= Q644), S865 (≠ K706), G866 (≠ S707), V867 (≠ L708), G868 (= G709), E869 (= E710)
Sites not aligning to the query:
- binding fe2/s2 (inorganic) cluster: 38, 40, 41, 43, 45, 46, 48, 58, 60, 100, 101, 103, 137, 139
- binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 99, 139
4c7yA Aldehyde oxidoreductase from desulfovibrio gigas (mop), soaked with sodium dithionite and sodium sulfide (see paper)
28% identity, 99% coverage: 2:744/752 of query aligns to 182:903/907 of 4c7yA
- active site: I390 (≠ Q206), F425 (≠ Q241), R501 (≠ A318), F505 (≠ K322), R533 (= R350), E869 (= E710), L870 (≠ P711)
- binding bicarbonate ion: R460 (= R277), L498 (≠ I315), A531 (= A348), Y535 (= Y352), Q539 (= Q356)
- binding magnesium ion: E899 (≠ K740), E903 (= E744)
- binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): T420 (≠ G236), F421 (= F237), G422 (= G238), R533 (= R350), W650 (≠ A471), H653 (≠ I474), G654 (= G475), Q655 (= Q476), G656 (= G477), S695 (≠ A514), G696 (≠ F515), Q700 (= Q519), Q701 (≠ S520), C799 (≠ L636), N800 (= N637), T804 (≠ A641), Q807 (= Q644), S865 (≠ K706), G866 (≠ S707), V867 (≠ L708), G868 (= G709), E869 (= E710)
- binding hydrogen peroxide: G696 (≠ F515), G697 (≠ A516), E869 (= E710)
Sites not aligning to the query:
- binding fe2/s2 (inorganic) cluster: 40, 41, 43, 45, 46, 48, 58, 60, 100, 101, 103, 137, 139
- binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 99, 139
3fc4A Ethylene glycol inhibited form of aldehyde oxidoreductase from desulfovibrio gigas (see paper)
28% identity, 99% coverage: 2:744/752 of query aligns to 182:903/907 of 3fc4A
- active site: I390 (≠ Q206), F425 (≠ Q241), R501 (≠ A318), F505 (≠ K322), R533 (= R350), E869 (= E710), L870 (≠ P711)
- binding 1,2-ethanediol: Y535 (= Y352), Y622 (= Y441), G696 (≠ F515), G697 (≠ A516), E869 (= E710)
- binding magnesium ion: E899 (≠ K740), E903 (= E744)
- binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): G419 (= G235), T420 (≠ G236), F421 (= F237), G422 (= G238), R533 (= R350), W650 (≠ A471), H653 (≠ I474), G654 (= G475), Q655 (= Q476), G656 (= G477), S695 (≠ A514), G696 (≠ F515), Q700 (= Q519), Q701 (≠ S520), C799 (≠ L636), N800 (= N637), T804 (≠ A641), Q807 (= Q644), S865 (≠ K706), G866 (≠ S707), V867 (≠ L708), G868 (= G709), E869 (= E710)
Sites not aligning to the query:
- binding fe2/s2 (inorganic) cluster: 38, 40, 41, 43, 45, 46, 48, 58, 60, 100, 101, 103, 137, 139
- binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 99, 139
3fahA Glycerol inhibited form of aldehyde oxidoreductase from desulfovibrio gigas (see paper)
28% identity, 99% coverage: 2:744/752 of query aligns to 182:903/907 of 3fahA
- active site: I390 (≠ Q206), F425 (≠ Q241), R501 (≠ A318), F505 (≠ K322), R533 (= R350), E869 (= E710), L870 (≠ P711)
- binding glycerol: P416 (= P231), Y535 (= Y352), Y622 (= Y441), W683 (≠ T502), G696 (≠ F515), G697 (≠ A516), E869 (= E710), K884 (= K725), V889 (= V730), R890 (≠ A731), Y892 (≠ N733)
- binding magnesium ion: E899 (≠ K740), E903 (= E744)
- binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): G419 (= G235), T420 (≠ G236), F421 (= F237), G422 (= G238), R533 (= R350), W650 (≠ A471), H653 (≠ I474), G654 (= G475), Q655 (= Q476), G656 (= G477), S695 (≠ A514), G696 (≠ F515), Q700 (= Q519), Q701 (≠ S520), C799 (≠ L636), N800 (= N637), T804 (≠ A641), Q807 (= Q644), S865 (≠ K706), G866 (≠ S707), V867 (≠ L708), G868 (= G709), E869 (= E710)
Sites not aligning to the query:
- binding fe2/s2 (inorganic) cluster: 38, 40, 41, 43, 45, 46, 48, 58, 60, 100, 101, 103, 137, 139
- binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 99, 139
1sijA Crystal structure of the aldehyde dehydrogenase (a.K.A. Aor or mop) of desulfovibrio gigas covalently bound to [aso3]- (see paper)
28% identity, 99% coverage: 2:744/752 of query aligns to 182:903/907 of 1sijA
- active site: I390 (≠ Q206), F425 (≠ Q241), R501 (≠ A318), F505 (≠ K322), R533 (= R350), E869 (= E710), L870 (≠ P711)
- binding arsenite: Y535 (= Y352), G696 (≠ F515), G697 (≠ A516), E869 (= E710)
- binding magnesium ion: E899 (≠ K740), E903 (= E744)
- binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): T420 (≠ G236), F421 (= F237), G422 (= G238), R533 (= R350), H653 (≠ I474), G654 (= G475), Q655 (= Q476), G656 (= G477), S695 (≠ A514), G696 (≠ F515), S698 (= S517), Q700 (= Q519), Q701 (≠ S520), C799 (≠ L636), N800 (= N637), T804 (≠ A641), Q807 (= Q644), S865 (≠ K706), G866 (≠ S707), V867 (≠ L708), G868 (= G709), E869 (= E710)
Sites not aligning to the query:
- binding fe2/s2 (inorganic) cluster: 38, 40, 41, 43, 45, 46, 48, 58, 60, 99, 100, 101, 103, 137, 139
- binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 99, 139
Q46509 Aldehyde oxidoreductase; Molybdenum iron sulfur protein; EC 1.2.99.7 from Megalodesulfovibrio gigas (Desulfovibrio gigas) (see paper)
28% identity, 99% coverage: 2:744/752 of query aligns to 182:903/907 of Q46509
Sites not aligning to the query:
- 40 binding
- 45 binding
- 48 binding
- 60 binding
- 100 binding
- 103 binding
- 137 binding
- 139 binding
Q0QLF2 Nicotinate dehydrogenase large molybdopterin subunit; NDH; Nicotinic acid hydroxylase large molybdopterin subunit; NAH; EC 1.17.1.5 from Eubacterium barkeri (Clostridium barkeri) (see 2 papers)
33% identity, 56% coverage: 1:420/752 of query aligns to 13:425/425 of Q0QLF2
Sites not aligning to the query:
- 1 modified: Initiator methionine, Removed
- 2:425 modified: mature protein, Nicotinate dehydrogenase large molybdopterin subunit
1zxiB Reconstituted co dehydrogenase from oligotropha carboxidovorans (see paper)
26% identity, 97% coverage: 2:727/752 of query aligns to 22:775/804 of 1zxiB
- active site: Q235 (= Q206), V270 (≠ Q241), P347 (≠ S317), I353 (≠ V323), R382 (= R350), C383 (vs. gap), E758 (= E710), S759 (≠ P711)
- binding copper (ii) ion: C383 (vs. gap), S384 (≠ G351), E758 (= E710)
- binding cu(i)-s-mo(vi)(=o)oh cluster: F266 (= F237), G267 (= G238), A380 (= A348), Y381 (≠ M349), R382 (= R350), C383 (vs. gap), Y563 (≠ F515), G564 (≠ A516), E758 (= E710)
- binding pterin cytosine dinucleotide: G265 (= G236), F266 (= F237), R382 (= R350), Q523 (≠ I474), G524 (= G475), Q525 (= Q476), H527 (≠ A478), T530 (≠ V481), T562 (≠ A514), Y563 (≠ F515), S565 (= S517), S567 (≠ Q519), T568 (≠ S520), C681 (≠ S632), I685 (≠ L636), I689 (≠ L640), I690 (≠ A641), Q693 (= Q644), K754 (= K706), G755 (≠ S707), V756 (≠ L708), E758 (= E710)
1n60B Crystal structure of the cu,mo-co dehydrogenase (codh); cyanide- inactivated form (see paper)
26% identity, 97% coverage: 2:727/752 of query aligns to 21:774/803 of 1n60B
- active site: Q234 (= Q206), V269 (≠ Q241), P346 (≠ S317), I352 (≠ V323), R381 (= R350), C382 (vs. gap), E757 (= E710), S758 (≠ P711)
- binding pterin cytosine dinucleotide: G264 (= G236), F265 (= F237), R381 (= R350), Q522 (≠ I474), G523 (= G475), Q524 (= Q476), H526 (≠ A478), T529 (≠ V481), T561 (≠ A514), Y562 (≠ F515), G563 (≠ A516), S564 (= S517), S566 (≠ Q519), T567 (≠ S520), C680 (≠ S632), I684 (≠ L636), I688 (≠ L640), I689 (≠ A641), Q692 (= Q644), K753 (= K706), G754 (≠ S707), V755 (≠ L708), E757 (= E710)
- binding mo(vi)(=o)(oh)2 cluster: F265 (= F237), G266 (= G238), Y562 (≠ F515), G563 (≠ A516), E757 (= E710)
Query Sequence
>16946 FitnessBrowser__Keio:16946
MRVDAIAKVTGRARYTDDYVMAGMCYAKYVRSPIAHGYAVSINDEQARSLPGVLAIFTWE
DVPDIPFATAGHAWTLDENKRDTADRALLTRHVRHHGDAVAIVVARDELTAEKAAQLVSI
EWQELPVITTPEAALAEDAAPIHNGGNLLKQSTMSTGNVQQTIDAADYQVQGHYQTPVIQ
HCHMESVTSLAWMEDDSRITIVSSTQIPHIVRRVVGQALDIPWSCVRVIKPFVGGGFGNK
QDVLEEPMAAFLTSKLGGIPVKVSLSREECFLATRTRHAFTIDGQMGVNRDGTLKGYSLD
VLSNTGAYASHGHSIASAGGNKVAYLYPRCAYAYSSKTCYTNLPSAGAMRGYGAPQVVFA
VESMLDDAATALGIDPVEIRLRNAAREGDANPLTGKRIYSAGLPECLEKGRKIFEWEKRR
AECQNQQGNLRRGVGVACFSYTSNTWPVGVEIAGARLLMNQDGTINVQSGATEIGQGADT
VFSQMVAETVGVPVSDVRVISTQDTDVTPFDPGAFASRQSYVAAPALRSAALLLKEKIIA
HAAVMLHQSAMNLTLIKGHIVLVERPEEPLMSLKDLAMDAFYHPERGGQLSAESSIKTTT
NPPAFGCTFVDLTVDIALCKVTINRILNVHDSGHILNPLLAEGQVHGGMGMGIGWALFEE
MIIDAKSGVVRNPNLLDYKMPTMPDLPQLESAFVEINEPQSAYGHKSLGEPPIIPVAAAI
RNAVKMATGVAINTLPLTPKRLYEEFHLAGLI
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory