SitesBLAST

Q0QLF3 Nicotinate dehydrogenase small FeS subunit; NDH; Nicotinic acid hydroxylase small FeS subunit; NAH; EC 1.17.1.5 from Eubacterium barkeri (Clostridium barkeri) (see paper)
48% identity, 89% coverage: 7:148/159 of query aligns to 4:144/157 of Q0QLF3

query
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Q0QLF3

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C42 (= C44) binding
C47 (= C49) binding
C50 (= C52) binding
C62 (= C64) binding
C101 (= C103) binding
C104 (= C106) binding
C136 (= C140) binding
C138 (= C142) binding

1t3qA Crystal structure of quinoline 2-oxidoreductase from pseudomonas putida 86 (see paper)
43% identity, 95% coverage: 4:154/159 of query aligns to 1:150/162 of 1t3qA

query
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1t3qA

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binding flavin-adenine dinucleotide: Q44 (≠ V46), G45 (= G47), V46 (≠ E48)
binding fe2/s2 (inorganic) cluster: I40 (≠ Q42), G41 (= G43), C42 (= C44), E43 (≠ C45), G45 (= G47), C47 (= C49), G48 (= G50), S49 (≠ A51), C50 (= C52), R60 (≠ D62), C62 (= C64), L99 (≠ V101), Q100 (= Q102), C101 (= C103), G102 (= G104), C104 (= C106), C136 (= C140), R137 (= R141), C138 (= C142)
binding pterin cytosine dinucleotide: Q100 (= Q102), C138 (= C142)

P19921 Carbon monoxide dehydrogenase small chain; CO dehydrogenase subunit S; CO-DH S; EC 1.2.5.3 from Afipia carboxidovorans (strain ATCC 49405 / DSM 1227 / KCTC 32145 / OM5) (Oligotropha carboxidovorans) (see 2 papers)
46% identity, 91% coverage: 9:152/159 of query aligns to 6:149/166 of P19921

query
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P19921

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C42 (= C44) binding
C47 (= C49) binding
C50 (= C52) binding
C62 (= C64) binding
C102 (= C103) binding
C105 (= C106) binding
C137 (= C140) binding
C139 (= C142) binding

5y6qA Crystal structure of an aldehyde oxidase from methylobacillus sp. Ky4400 (see paper)
41% identity, 93% coverage: 5:152/159 of query aligns to 1:148/157 of 5y6qA

query
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5y6qA

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binding flavin-adenine dinucleotide: G44 (= G47), Q45 (≠ E48)
binding fe2/s2 (inorganic) cluster: K39 (≠ Q42), G40 (= G43), C41 (= C44), D42 (≠ C45), G44 (= G47), C46 (= C49), G47 (= G50), C49 (= C52), C61 (= C64), F99 (≠ V101), Q100 (= Q102), C101 (= C103), G102 (= G104), C104 (= C106), C136 (= C140), R137 (= R141), C138 (= C142)
binding pterin cytosine dinucleotide: Q100 (= Q102), C101 (= C103), C138 (= C142)

1n5wA Crystal structure of the cu,mo-co dehydrogenase (codh); oxidized form (see paper)
46% identity, 91% coverage: 9:152/159 of query aligns to 4:147/161 of 1n5wA

query
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1n5wA

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binding flavin-adenine dinucleotide: T42 (≠ V46), S43 (≠ G47), H44 (≠ E48)
binding fe2/s2 (inorganic) cluster: I38 (≠ Q42), G39 (= G43), C40 (= C44), S43 (≠ G47), H44 (≠ E48), C45 (= C49), G46 (= G50), C48 (= C52), K58 (≠ D62), C60 (= C64), L98 (≠ V101), Q99 (= Q102), C100 (= C103), G101 (= G104), C103 (= C106), C135 (= C140), R136 (= R141), C137 (= C142)
binding pterin cytosine dinucleotide: Q99 (= Q102), C137 (= C142)

1ffuD Carbon monoxide dehydrogenase from hydrogenophaga pseudoflava which lacks the mo-pyranopterin moiety of the molybdenum cofactor (see paper)
45% identity, 91% coverage: 9:152/159 of query aligns to 5:147/156 of 1ffuD

query
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1ffuD

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binding flavin-adenine dinucleotide: S44 (≠ G47), H45 (≠ E48)
binding fe2/s2 (inorganic) cluster: I39 (≠ Q42), G40 (= G43), C41 (= C44), S44 (≠ G47), H45 (≠ E48), C46 (= C49), G47 (= G50), C49 (= C52), K59 (≠ D62), C61 (= C64), Q99 (= Q102), C100 (= C103), G101 (= G104), C103 (= C106), C135 (= C140), R136 (= R141), C137 (= C142)

1ffvA Carbon monoxide dehydrogenase from hydrogenophaga pseudoflava (see paper)
45% identity, 91% coverage: 9:152/159 of query aligns to 4:146/155 of 1ffvA

query
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1ffvA

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binding flavin-adenine dinucleotide: T42 (≠ V46), S43 (≠ G47), H44 (≠ E48)
binding fe2/s2 (inorganic) cluster: I38 (≠ Q42), G39 (= G43), C40 (= C44), S43 (≠ G47), H44 (≠ E48), C45 (= C49), G46 (= G50), C48 (= C52), K58 (≠ D62), C60 (= C64), L97 (≠ V101), Q98 (= Q102), C99 (= C103), G100 (= G104), C102 (= C106), C134 (= C140), R135 (= R141), C136 (= C142)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q98 (= Q102), C136 (= C142)

1sb3C Structure of 4-hydroxybenzoyl-coa reductase from thauera aromatica (see paper)
46% identity, 91% coverage: 9:152/159 of query aligns to 5:147/161 of 1sb3C

query
sites
1sb3C

I

L

E

R

C

L

T

T

I

L

N

N

G

G

M

R

P

A

F

R

Q

E

L

D

H

L

A

V

A

P

P

D

G

N

T

M

P

L

L

L

S

L

E

D

L

Y

L

L

R

R

E

E

Q

T

-

V

G

G

L

L

L

T

S

G

V

T

K

K

Q
|
Q

G
|
G

C
|
C

C

D

V

G

G
|
G

E
|
E

C
|
C

G
|
G

A

A

C
|
C

T

T

V

V

L

L

V

V

D

D

G

D

T

R

A

P

I

R

D
x
L

S

A

C
|
C

L

S

Y

T

L

L

A

A

A

H

W

Q

A

V

E

A

G

G

K

K

E

K

I

V

R

E

T

T

L

V

E

E

G

S

E

L

A

A

K

T

G

Q

G

G

K

T

L

L

S

S

H

K

V

L

Q

Q

Q

A

A

A

Y

F

A

H

K

E

S

K

G

L

A

G

V

T

Q
|
Q

C
|
C

G
|
G

F

F

C
|
C

T

T

P

P

G

G

L

M

I

I

M

M

A

A

T

S

T

E

A

A

M

L

L

L

A

-

K

-

P

-

R

R

E

K

K

N

P

P

L

S

-

P

T

S

I

R

T

D

E

E

I

I

R

K

R

A

G

A

L

L

A

A

G

G

N

N

L

L

C
|
C

R
|
R

C
|
C

T

T

G

G

Y

Y

Q

V

M

K

I

I

V

I

N

K

T

S

V

V

binding flavin-adenine dinucleotide: G44 (= G47), E45 (= E48)
binding fe2/s2 (inorganic) cluster: Q39 (= Q42), G40 (= G43), C41 (= C44), G44 (= G47), E45 (= E48), C46 (= C49), G47 (= G50), C49 (= C52), L59 (≠ D62), C61 (= C64), Q99 (= Q102), C100 (= C103), G101 (= G104), C103 (= C106), C135 (= C140), R136 (= R141), C137 (= C142)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q102), C137 (= C142)

7dqxC Crystal structure of xanthine dehydrogenase family protein
40% identity, 93% coverage: 7:154/159 of query aligns to 6:151/160 of 7dqxC

query
sites
7dqxC

I

L

T

T

I

V

E

E

C

-

T

-

I

V

N

N

G

G

M

V

P

T

F

H

Q

A

L

T

H

D

A

V

A

E

P

P

G

R

T

R

P

L

L

L

S

A

E

D

L

F

L

L

R

R

E

D

Q

D

-

L

G

H

L

L

L

R

S

G

V

T

K

R

Q

V

G

G

C
|
C

C
x
E

V
x
H

G
|
G

E
x
V

C
|
C

G

G

A

S

C
|
C

T

T

V

V

L

I

V

L

D

D

G

G

T

Q

A

P

I

V

D
x
R

S

S

C
|
C

L

T

Y

V

L

L

A

A

A

V

W

Q

A

A

E

N

G

N

K

S

E

R

I

I

R

E

T

T

L

V

E

E

G

S

E

L

A

Q

K

K

G

D

G

G

K

Q

L

L

S

H

H

P

V

L

Q

Q

Q

R

A

S

Y

F

A

S

K

K

S

C

G

H

A

A

V

L

Q
|
Q

C
|
C

G

G

F

F

C
|
C

T

T

P

S

G

G

L

F

I

L

M

M

A

-

T

T

T

L

A

K

M

P

L

L

A

Y

K

D

P

D

R

E

E

D

K

V

P

T

L

L

T

D

I

A

T

T

E

S

I

A

R

R

R

E

G

A

L

I

A

S

G

G

N

N

L

L

C
|
C

R

R

C
|
C

T

T

G

G

Y

Y

Q

Q

M

Q

I

I

V

V

N

E

T

A

V

T

L

V

D

D

binding flavin-adenine dinucleotide: H44 (≠ V46), G45 (= G47)
binding fe2/s2 (inorganic) cluster: C42 (= C44), E43 (≠ C45), G45 (= G47), V46 (≠ E48), C47 (= C49), C50 (= C52), R60 (≠ D62), C62 (= C64), Q100 (= Q102), C101 (= C103), C104 (= C106), C137 (= C140), C139 (= C142)
binding pterin cytosine dinucleotide: Q100 (= Q102), C101 (= C103), C139 (= C142)

1dgjA Crystal structure of the aldehyde oxidoreductase from desulfovibrio desulfuricans atcc 27774 (see paper)
40% identity, 90% coverage: 13:155/159 of query aligns to 8:152/906 of 1dgjA

query
sites
1dgjA

I

V

N

N

G

G

M

M

P

A

F

R

Q

R

L

L

H

L

A

V

A

S

P

P

G

N

T

D

P

L

L

L

S

V

E

D

L

V

L

L

R

R

E

S

Q

Q

-

L

G

Q

L

L

L

T

S

S

V

V

K

K

Q
x
V

G
|
G

C
|
C

C
x
G

V

K

G
|
G

E
x
Q

C
|
C

G
|
G

A
|
A

C
|
C

T

T

V

V

L

I

V

L

D

D

G

G

T

K

A

V

I

V

D
x
R

S

A

C
|
C

L

I

Y

I

-

K

L

M

A

S

A

R

W

V

A

A

E

E

G

N

K

A

E

S

I

V

R

T

T

T

L

L

E

E

G

G

E

I

A

G

K

A

G

P

G

D

K

C

L

L

S

H

H

P

V

L

Q

Q

Q

H

A

A

Y

W

A

I

K

Q

S

H

G

G

A

A

V

A

Q
|
Q

C
|
C

G
|
G

F

F

C
|
C

T

T

P

P

G

G

L

F

I

I

M

V

A

S

T

A

T

K

A

A

M

L

L

L

-

D

-

E

-

N

-

V

A

A

K

P

P

S

R

R

E

E

K

-

P

-

L

-

T

-

I

-

T

-

E

D

I

V

R

R

R

D

G

W

L

F

A

Q

G

K

-

H

N

N

L

I

C
|
C

R
|
R

C
|
C

T

T

G

G

Y

Y

Q

K

M

P

I

L

V

V

N

D

T

A

V

V

L

M

D

D

C

A

binding fe2/s2 (inorganic) cluster: V38 (≠ Q42), G39 (= G43), C40 (= C44), G41 (≠ C45), G43 (= G47), Q44 (≠ E48), C45 (= C49), G46 (= G50), A47 (= A51), C48 (= C52), R58 (≠ D62), C60 (= C64), Q99 (= Q102), C100 (= C103), G101 (= G104), C103 (= C106), C137 (= C140), R138 (= R141), C139 (= C142)
binding pterin cytosine dinucleotide: Q99 (= Q102), C139 (= C142)

Sites not aligning to the query:

active site: 391, 427, 503, 507, 535, 869, 870
binding molybdenum (iv)oxide: 424, 533, 534, 535, 655, 698, 869
binding pterin cytosine dinucleotide: 421, 422, 423, 424, 535, 652, 655, 656, 657, 658, 662, 697, 698, 700, 701, 702, 703, 797, 798, 799, 800, 803, 804, 807, 865, 866, 867, 868, 869

P77165 Aldehyde oxidoreductase iron-sulfur-binding subunit PaoA; EC 1.2.99.6 from Escherichia coli (strain K12) (see paper)
36% identity, 94% coverage: 5:154/159 of query aligns to 59:222/229 of P77165

query
sites
P77165

E

E

T

I

I

M

T

P

I

L

E

T

C

L

T

K

I

V

N

N

G

G

M

K

P

T

F

E

Q

Q

L

L

H

E

A

V

A

D

P

T

G

R

T

T

P

T

L

L

S

L

E

D

L

T

L

L

R

R

E

E

Q

N

-

L

G

H

L

L

L

I

S

G

V

T

K

K

Q

K

G

G

C
|
C

C

D

V

H

G

G

E

Q

C
|
C

G
|
G

A

A

C
|
C

T

T

V

V

L

L

V

V

D

N

G

G

T

R

A

R

I

L

D

N

S

A

C
|
C

L

L

Y

T

L

L

A

A

A

V

W

M

A

H

E

Q

G

G

K

A

E

E

I

I

R

T

T

T

L

I

E

E

G

G

E

L

A

G

K

S

G

P

G

D

K

N

L

L

S

H

H

P

V

M

Q

Q

Q

A

A

A

Y

F

A

I

K

K

S

H

G

D

A

G

V

F

Q

Q

C
|
C

G

G

F

Y

C
|
C

T

T

P

S

G

G

L

Q

I

I

M

C

A

S

T

S

T

V

A

A

M

V

L

L

A

K

K

E

P

I

R

Q

E

D

-

G

-

I

-

P

-

S

-

H

-

V

-

T

-

V

-

D

-

L

-

V

-

S

-

A

K

P

P

E

L

T

T

T

I

A

T

D

E

E

I

I

R

R

R

E

G

R

L

M

A

S

G

G

N

N

L

I

C
|
C

R

R

C
|
C

T

G

G

A

Y

Y

Q

A

M

N

I

I

V

L

N

A

T

A

V

I

L

E

D

D

C99 (= C44) binding
C104 (= C49) binding
G105 (= G50) binding
C107 (= C52) binding
C119 (= C64) binding
C158 (= C103) binding
C161 (= C106) binding
C208 (= C140) binding
C210 (= C142) binding

5g5gA Escherichia coli periplasmic aldehyde oxidase (see paper)
36% identity, 94% coverage: 5:154/159 of query aligns to 8:171/175 of 5g5gA

query
sites
5g5gA

E

E

T

I

I

M

T

P

I

L

E

T

C

L

T

K

I

V

N

N

G

G

M

K

P

T

F

E

Q

Q

L

L

H

E

A

V

A

D

P

T

G

R

T

T

P

T

L

L

S

L

E

D

L

T

L

L

R

R

E

E

Q

N

-

L

G

H

L

L

L

I

S

G

V

T

K

K

Q
x
K

G
|
G

C
|
C

C
x
D

V

H

G
|
G

E
x
Q

C
|
C

G
|
G

A

A

C
|
C

T

T

V

V

L

L

V

V

D

N

G

G

T

R

A

R

I

L

D
x
N

S

A

C
|
C

L

L

Y

T

L

L

A

A

A

V

W

M

A

H

E

Q

G

G

K

A

E

E

I

I

R

T

T

T

L

I

E

E

G

G

E

L

A

G

K

S

G

P

G

D

K

N

L

L

S

H

H

P

V

M

Q

Q

Q

A

A

A

Y

F

A

I

K

K

S

H

G

D

A

G

V

F

Q
|
Q

C
|
C

G
|
G

F

Y

C
|
C

T

T

P

S

G

G

L

Q

I

I

M

C

A

S

T

S

T

V

A

A

M

V

L

L

A

K

K

E

P

I

R

Q

E

D

-

G

-

I

-

P

-

S

-

H

-

V

-

T

-

V

-

D

-

L

-

V

-

S

-

A

K

P

P

E

L

T

T

T

I

A

T

D

E

E

I

I

R

R

R

E

G

R

L

M

A

S

G

G

N

N

L

I

C
|
C

R

R

C
|
C

T

G

G

A

Y

Y

Q

A

M

N

I

I

V

L

N

A

T

A

V

I

L

E

D

D

binding flavin-adenine dinucleotide: G51 (= G47), Q52 (≠ E48)
binding fe2/s2 (inorganic) cluster: K46 (≠ Q42), G47 (= G43), C48 (= C44), D49 (≠ C45), G51 (= G47), Q52 (≠ E48), C53 (= C49), G54 (= G50), C56 (= C52), N66 (≠ D62), C68 (= C64), Q106 (= Q102), C107 (= C103), G108 (= G104), C110 (= C106), C157 (= C140), C159 (= C142)
binding pterin cytosine dinucleotide: Q106 (= Q102), C159 (= C142)

1jroA Crystal structure of xanthine dehydrogenase from rhodobacter capsulatus (see paper)
43% identity, 80% coverage: 24:150/159 of query aligns to 19:144/450 of 1jroA

query
sites
1jroA

P

P

G

T

T

Q

P

S

L

L

S

L

E

E

L

L

R

R

E

A

Q

E

G

G

L

L

L

T

S

G

V

T

K

K

Q
x
E

G
|
G

C
|
C

C
x
N

V
x
E

G
|
G

E
x
D

C
|
C

G
|
G

A

A

C
|
C

T

T

V

V

L

M

V

I

D

R

G

D

T

A

-

A

-

G

-

S

-

R

A

A

I

V

D

N

S

A

C
|
C

L

L

Y

M

L

M

A

L

A

P

W

Q

A

I

E

A

G

G

K

K

E

A

I

L

R

R

T

T

L

I

E

E

G

G

-

I

E

A

A

A

K

P

G

D

G

G

K

R

L

L

S

H

H

P

V

V

Q

Q

A

A

Y

M

A

I

K

D

S

H

G

H

A

G

V

S

Q
|
Q

C
|
C

G
|
G

F

F

C
|
C

T

T

P

P

G

G

L

F

I

I

M

V

A

S

T

M

T

A

A

A

M

A

L

H

A

D

K

R

P

D

R

R

E

K

K

D

P

Y

L

D

T

D

I

L

T

-

E

-

I

-

R

-

G

-

L

L

A

A

G

G

N

N

L

L

C
|
C

R

R

C
|
C

T

T

G

G

Y

Y

Q

A

M

P

I

I

V

L

N

R

binding flavin-adenine dinucleotide: E41 (≠ V46), G42 (= G47), D43 (≠ E48)
binding fe2/s2 (inorganic) cluster: E37 (≠ Q42), G38 (= G43), C39 (= C44), N40 (≠ C45), G42 (= G47), D43 (≠ E48), C44 (= C49), G45 (= G50), C47 (= C52), C63 (= C64), Q102 (= Q102), C103 (= C103), G104 (= G104), C106 (= C106), C134 (= C140), C136 (= C142)

Sites not aligning to the query:

binding flavin-adenine dinucleotide: 189, 190, 191, 192, 193, 194, 195, 196, 199, 213, 258, 259, 263, 267, 268, 271, 272, 274, 275, 280, 281, 318, 323, 324, 340, 347

4usaA Aldehyde oxidoreductase from desulfovibrio gigas (mop), soaked with trans-cinnamaldehyde (see paper)
39% identity, 91% coverage: 12:155/159 of query aligns to 7:152/907 of 4usaA

query
sites
4usaA

T

T

I

V

N

N

G

G

M

I

P

E

F

Q

Q

N

L

L

H

F

A

V

A

D

P

A

G

E

T

A

P

L

L

L

S

S

E

D

L

V

L

L

R

R

E

Q

Q

Q

-

L

G

G

L

L

L

T

S

G

V

V

K

K

Q
x
V

G
|
G

C
|
C

C
x
E

V

Q

G
|
G

E
x
Q

C
|
C

G
|
G

A

A

C
|
C

T

S

V

V

L

I

V

L

D

D

G

G

T

K

A

V

I

V

D
x
R

S

A

C
|
C

L

V

-

T

Y

K

L

M

A

K

A

R

W

V

A

A

E

D

G

G

K

A

E

Q

I

I

R

T

T

T

L

I

E

E

G

G

E

V

A

G

K

Q

G

P

G

E

K

N

L

L

S

H

H

P

V

L

Q

Q

Q

K

A

A

Y

W

A

V

K

L

S

H

G

G

A

G

V

A

Q
|
Q

C
|
C

G
|
G

F

F

C
|
C

T

S

P

P

G

G

L

F

I

I

M

V

A

S

T

A

T

K

A

G

M

L

L

L

-

D

-

T

-

N

A

A

K

D

P

P

-

S

R

R

E

E

K

D

P

V

L

R

T

D

I

W

T

F

E

Q

I

K

R

H

R

R

G

-

L

-

A

-

G

-

N

N

L

A

C
|
C

R
|
R

C
|
C

T

T

G

G

Y

Y

Q

K

M

P

I

L

V

V

N

D

T

A

V

V

L

M

D

D

C

A

binding fe2/s2 (inorganic) cluster: V38 (≠ Q42), G39 (= G43), C40 (= C44), E41 (≠ C45), G43 (= G47), Q44 (≠ E48), C45 (= C49), G46 (= G50), C48 (= C52), R58 (≠ D62), C60 (= C64), Q99 (= Q102), C100 (= C103), G101 (= G104), C103 (= C106), C137 (= C140), R138 (= R141), C139 (= C142)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q102), C139 (= C142)

Sites not aligning to the query:

active site: 390, 425, 501, 505, 533, 869, 870
binding bicarbonate ion: 460, 461, 498, 531, 532, 535, 536, 539
binding hydrocinnamic acid: 255, 425, 494, 497, 501, 535, 626
binding magnesium ion: 899, 903
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 419, 420, 421, 422, 531, 532, 533, 650, 653, 654, 655, 656, 660, 695, 696, 697, 698, 699, 700, 701, 795, 797, 798, 799, 800, 803, 804, 807, 865, 866, 867, 868, 869

4us9A Aldehyde oxidoreductase from desulfovibrio gigas (mop), soaked with 3- phenylpropionaldehyde (see paper)
39% identity, 91% coverage: 12:155/159 of query aligns to 7:152/907 of 4us9A

query
sites
4us9A

T

T

I

V

N

N

G

G

M

I

P

E

F

Q

Q

N

L

L

H

F

A

V

A

D

P

A

G

E

T

A

P

L

L

L

S

S

E

D

L

V

L

L

R

R

E

Q

Q

Q

-

L

G

G

L

L

L

T

S

G

V

V

K

K

Q
x
V

G
|
G

C
|
C

C
x
E

V

Q

G
|
G

E

Q

C
|
C

G
|
G

A

A

C
|
C

T

S

V

V

L

I

V

L

D

D

G

G

T

K

A

V

I

V

D
x
R

S

A

C
|
C

L

V

-

T

Y

K

L

M

A

K

A

R

W

V

A

A

E

D

G

G

K

A

E

Q

I

I

R

T

T

T

L

I

E

E

G

G

E

V

A

G

K

Q

G

P

G

E

K

N

L

L

S

H

H

P

V

L

Q

Q

Q

K

A

A

Y

W

A

V

K

L

S

H

G

G

A

G

V

A

Q
|
Q

C
|
C

G
|
G

F

F

C
|
C

T

S

P

P

G

G

L

F

I

I

M

V

A

S

T

A

T

K

A

G

M

L

L

L

-

D

-

T

-

N

A

A

K

D

P

P

-

S

R

R

E

E

K

D

P

V

L

R

T

D

I

W

T

F

E

Q

I

K

R

H

R

R

G

-

L

-

A

-

G

-

N

N

L

A

C
|
C

R
|
R

C
|
C

T

T

G

G

Y

Y

Q

K

M

P

I

L

V

V

N

D

T

A

V

V

L

M

D

D

C

A

binding fe2/s2 (inorganic) cluster: V38 (≠ Q42), G39 (= G43), C40 (= C44), E41 (≠ C45), G43 (= G47), C45 (= C49), G46 (= G50), C48 (= C52), R58 (≠ D62), C60 (= C64), Q99 (= Q102), C100 (= C103), G101 (= G104), C103 (= C106), C137 (= C140), R138 (= R141), C139 (= C142)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q102), C139 (= C142)

Sites not aligning to the query:

active site: 390, 425, 501, 505, 533, 869, 870
binding 3-phenylpropanal: 255, 256, 257, 258, 752, 753, 755
binding bicarbonate ion: 460, 461, 498, 531, 532, 535, 536, 539, 884, 888, 889, 890, 892
binding magnesium ion: 899, 903
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 419, 420, 421, 422, 425, 531, 532, 533, 650, 653, 654, 655, 656, 660, 695, 696, 697, 698, 699, 700, 701, 795, 797, 798, 799, 800, 803, 804, 807, 865, 866, 867, 868, 869

4us8A Aldehyde oxidoreductase from desulfovibrio gigas (mop), soaked with benzaldehyde (see paper)
39% identity, 91% coverage: 12:155/159 of query aligns to 7:152/907 of 4us8A

query
sites
4us8A

T

T

I

V

N

N

G

G

M

I

P

E

F

Q

Q

N

L

L

H

F

A

V

A

D

P

A

G

E

T

A

P

L

L

L

S

S

E

D

L

V

L

L

R

R

E

Q

Q

Q

-

L

G

G

L

L

L

T

S

G

V

V

K

K

Q
x
V

G
|
G

C
|
C

C
x
E

V

Q

G
|
G

E
x
Q

C
|
C

G
|
G

A

A

C
|
C

T

S

V

V

L

I

V

L

D

D

G

G

T

K

A

V

I

V

D
x
R

S

A

C
|
C

L

V

-

T

Y

K

L

M

A

K

A

R

W

V

A

A

E

D

G

G

K

A

E

Q

I

I

R

T

T

T

L

I

E

E

G

G

E

V

A

G

K

Q

G

P

G

E

K

N

L

L

S

H

H

P

V

L

Q

Q

Q

K

A

A

Y

W

A

V

K

L

S

H

G

G

A

G

V

A

Q
|
Q

C
|
C

G
|
G

F

F

C
|
C

T

S

P

P

G

G

L

F

I

I

M

V

A

S

T

A

T

K

A

G

M

L

L

L

-

D

-

T

-

N

A

A

K

D

P

P

-

S

R

R

E

E

K

D

P

V

L

R

T

D

I

W

T

F

E

Q

I

K

R

H

R

R

G

-

L

-

A

-

G

-

N

N

L

A

C
|
C

R
|
R

C
|
C

T

T

G

G

Y

Y

Q

K

M

P

I

L

V

V

N

D

T

A

V

V

L

M

D

D

C

A

binding fe2/s2 (inorganic) cluster: V38 (≠ Q42), G39 (= G43), C40 (= C44), E41 (≠ C45), G43 (= G47), Q44 (≠ E48), C45 (= C49), G46 (= G50), C48 (= C52), R58 (≠ D62), C60 (= C64), Q99 (= Q102), C100 (= C103), G101 (= G104), C103 (= C106), C137 (= C140), R138 (= R141), C139 (= C142)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q102), C139 (= C142)

Sites not aligning to the query:

active site: 390, 425, 501, 505, 533, 869, 870
binding bicarbonate ion: 460, 461, 498, 531, 532, 535, 536, 539
binding benzaldehyde: 255, 255, 394, 394, 425, 425, 425, 425, 494, 497, 497, 497, 501, 501, 531, 531, 535, 535, 626, 626, 626, 627, 694, 696, 697, 697, 869
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 419, 420, 421, 422, 531, 532, 533, 650, 653, 654, 655, 656, 660, 695, 696, 697, 698, 699, 700, 701, 795, 797, 798, 799, 800, 803, 804, 807, 865, 866, 867, 868, 869

4c7yA Aldehyde oxidoreductase from desulfovibrio gigas (mop), soaked with sodium dithionite and sodium sulfide (see paper)
39% identity, 91% coverage: 12:155/159 of query aligns to 7:152/907 of 4c7yA

query
sites
4c7yA

T

T

I

V

N

N

G

G

M

I

P

E

F

Q

Q

N

L

L

H

F

A

V

A

D

P

A

G

E

T

A

P

L

L

L

S

S

E

D

L

V

L

L

R

R

E

Q

Q

Q

-

L

G

G

L

L

L

T

S

G

V

V

K

K

Q
x
V

G
|
G

C
|
C

C
x
E

V

Q

G
|
G

E

Q

C
|
C

G
|
G

A

A

C
|
C

T

S

V

V

L

I

V

L

D

D

G

G

T

K

A

V

I

V

D
x
R

S

A

C
|
C

L

V

-

T

Y

K

L

M

A

K

A

R

W

V

A

A

E

D

G

G

K

A

E

Q

I

I

R

T

T

T

L

I

E

E

G

G

E

V

A

G

K

Q

G

P

G

E

K

N

L

L

S

H

H

P

V

L

Q

Q

Q

K

A

A

Y

W

A

V

K

L

S

H

G

G

A

G

V

A

Q
|
Q

C
|
C

G
|
G

F

F

C
|
C

T

S

P

P

G

G

L

F

I

I

M

V

A

S

T

A

T

K

A

G

M

L

L

L

-

D

-

T

-

N

A

A

K

D

P

P

-

S

R

R

E

E

K

D

P

V

L

R

T

D

I

W

T

F

E

Q

I

K

R

H

R

R

G

-

L

-

A

-

G

-

N

N

L

A

C
|
C

R

R

C
|
C

T

T

G

G

Y

Y

Q

K

M

P

I

L

V

V

N

D

T

A

V

V

L

M

D

D

C

A

binding fe2/s2 (inorganic) cluster: V38 (≠ Q42), G39 (= G43), C40 (= C44), E41 (≠ C45), G43 (= G47), C45 (= C49), G46 (= G50), C48 (= C52), R58 (≠ D62), C60 (= C64), Q99 (= Q102), C100 (= C103), G101 (= G104), C103 (= C106), C137 (= C140), C139 (= C142)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q102), C139 (= C142)

Sites not aligning to the query:

active site: 390, 425, 501, 505, 533, 869, 870
binding bicarbonate ion: 460, 461, 498, 531, 532, 535, 536, 539
binding magnesium ion: 899, 903
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 419, 420, 421, 422, 531, 532, 533, 650, 653, 654, 655, 656, 660, 695, 696, 698, 699, 700, 701, 795, 797, 798, 799, 800, 803, 804, 807, 865, 866, 867, 868, 869
binding hydrogen peroxide: 696, 697, 869

3fc4A Ethylene glycol inhibited form of aldehyde oxidoreductase from desulfovibrio gigas (see paper)
39% identity, 91% coverage: 12:155/159 of query aligns to 7:152/907 of 3fc4A

query
sites
3fc4A

T

T

I

V

N

N

G

G

M

I

P

E

F

Q

Q

N

L

L

H

F

A

V

A

D

P

A

G

E

T

A

P

L

L

L

S

S

E

D

L

V

L

L

R

R

E

Q

Q

Q

-

L

G

G

L

L

L

T

S

G

V

V

K

K

Q
x
V

G
|
G

C
|
C

C
x
E

V

Q

G
|
G

E
x
Q

C
|
C

G
|
G

A

A

C
|
C

T

S

V

V

L

I

V

L

D

D

G

G

T

K

A

V

I

V

D
x
R

S

A

C
|
C

L

V

-

T

Y

K

L

M

A

K

A

R

W

V

A

A

E

D

G

G

K

A

E

Q

I

I

R

T

T

T

L

I

E

E

G

G

E

V

A

G

K

Q

G

P

G

E

K

N

L

L

S

H

H

P

V

L

Q

Q

Q

K

A

A

Y

W

A

V

K

L

S

H

G

G

A

G

V

A

Q
|
Q

C
|
C

G
|
G

F

F

C
|
C

T

S

P

P

G

G

L

F

I

I

M

V

A

S

T

A

T

K

A

G

M

L

L

L

-

D

-

T

-

N

A

A

K

D

P

P

-

S

R

R

E

E

K

D

P

V

L

R

T

D

I

W

T

F

E

Q

I

K

R

H

R

R

G

-

L

-

A

-

G

-

N

N

L

A

C
|
C

R
|
R

C
|
C

T

T

G

G

Y

Y

Q

K

M

P

I

L

V

V

N

D

T

A

V

V

L

M

D

D

C

A

binding fe2/s2 (inorganic) cluster: V38 (≠ Q42), G39 (= G43), C40 (= C44), E41 (≠ C45), G43 (= G47), Q44 (≠ E48), C45 (= C49), G46 (= G50), C48 (= C52), R58 (≠ D62), C60 (= C64), Q99 (= Q102), C100 (= C103), G101 (= G104), C103 (= C106), C137 (= C140), R138 (= R141), C139 (= C142)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q102), C139 (= C142)

Sites not aligning to the query:

active site: 390, 425, 501, 505, 533, 869, 870
binding 1,2-ethanediol: 425, 531, 535, 622, 696, 697, 869
binding magnesium ion: 899, 903
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 419, 420, 421, 422, 425, 531, 532, 533, 650, 653, 654, 655, 656, 660, 695, 696, 698, 699, 700, 701, 795, 797, 798, 799, 800, 803, 804, 807, 865, 866, 867, 868, 869

Query Sequence

>16948 FitnessBrowser__Keio:16948
MNHSETITIECTINGMPFQLHAAPGTPLSELLREQGLLSVKQGCCVGECGACTVLVDGTA
IDSCLYLAAWAEGKEIRTLEGEAKGGKLSHVQQAYAKSGAVQCGFCTPGLIMATTAMLAK
PREKPLTITEIRRGLAGNLCRCTGYQMIVNTVLDCEKTK

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory