SitesBLAST – Find functional sites

 

SitesBLAST

Comparing 17013 FitnessBrowser__Keio:17013 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 3 hits to proteins with known functional sites (download)

1j6tA Complex of enzyme iiamtl and the histidine-containing phosphocarrier protein hpr from escherichia coli nmr, restrained regularized mean structure (see paper)
29% identity, 88% coverage: 16:145/147 of query aligns to 13:142/144 of 1j6tA

query
sites
1j6tA
H
 
R
S
 
K
A
 
A
K
 
A
D
 
T
W
 
K
Q
 
E
E
 
E
A
 
A
I
 
I
D
 
R
F
 
F
S
 
A
M
 
G
V
 
E
S
 
Q
L
 
L
L
 
V
D
 
K
K
 
G
N
 
G
Y
 
Y
I
 
V
S
 
E
E
 
P
N
 
E
Y
 
Y
I
 
V
Q
 
Q
A
 
A
I
 
M
K
 
L
D
 
D
S
x
R
T
 
E
I
 
-
N
 
K
N
 
L
G
 
T
P
 
P
Y
 
T
Y
 
Y
I
 
-
L
 
L
A
 
G
P
 
E
G
 
S
V
 
I
A
 
A
M
 
V
P
 
P
H
|
H
A
 
G
R
 
T
P
 
V
E
 
E
C
 
A
G
 
K
-
 
D
-
 
R
A
 
V
L
 
L
K
 
K
T
 
T
G
 
G
M
 
V
S
 
V
L
 
F
T
 
C
L
 
Q
L
 
Y
E
 
P
Q
 
E
G
 
G
V
 
V
Y
 
R
F
 
F
P
 
G
G
 
E
N
 
E
D
 
E
E
 
D
P
 
D
I
 
I
-
 
A
K
 
R
L
 
L
L
 
V
I
 
I
G
 
G
L
 
I
S
 
A
A
 
A
A
 
R
D
 
N
A
 
-
D
 
N
S
 
E
H
|
H
I
 
I
G
 
Q
A
 
V
I
 
I
Q
 
T
A
 
S
L
 
L
S
 
T
E
 
N
L
 
A
L
 
L
C
 
D
E
 
D
E
 
E
E
 
S
I
 
V
L
 
I
E
 
E
Q
 
R
L
 
L
L
 
A
T
 
H
A
 
T
S
 
T
S
 
S
E
 
V
K
 
D
Q
 
E
L
 
V
A
 
L
D
 
E
I
 
L
I
 
L
S
 
A

P00550 PTS system mannitol-specific EIICBA component; EIICBA-Mtl; EII-Mtl; EC 2.7.1.197 from Escherichia coli (strain K12) (see 2 papers)
28% identity, 97% coverage: 3:145/147 of query aligns to 482:634/637 of P00550

query
sites
P00550
L
 
L
S
 
K
D
 
D
Y
 
S
F
 
F
P
 
D
E
 
D
S
 
S
S
 
S
I
 
A
S
 
N
V
 
L
I
 
F
-
 
K
-
 
L
-
 
G
-
 
A
-
 
E
-
 
N
-
 
I
-
 
F
-
 
L
-
 
G
H
 
R
S
 
K
A
 
A
K
 
A
D
 
T
W
 
K
Q
 
E
E
 
E
A
 
A
I
 
I
D
 
R
F
 
F
S
 
A
M
 
G
V
 
E
S
 
Q
L
 
L
L
 
V
D
 
K
K
 
G
N
 
G
Y
 
Y
I
 
V
S
 
E
E
 
P
N
 
E
Y
 
Y
I
 
V
Q
 
Q
A
 
A
I
 
M
K
 
L
D
 
D
S
x
R
T
 
E
I
 
-
N
 
K
N
 
L
G
 
T
P
 
P
Y
 
T
Y
 
Y
I
 
-
L
 
L
A
 
G
P
 
E
G
 
S
V
 
I
A
 
A
M
 
V
P
 
P
H
|
H
A
 
G
R
 
T
P
 
V
E
 
E
C
 
A
G
 
K
-
 
D
-
 
R
A
 
V
L
 
L
K
 
K
T
 
T
G
 
G
M
 
V
S
 
V
L
 
F
T
 
C
L
 
Q
L
 
Y
E
 
P
Q
 
E
G
 
G
V
 
V
Y
 
R
F
 
F
P
 
G
G
 
E
N
 
E
D
 
E
E
 
D
P
 
D
I
 
I
-
 
A
K
 
R
L
 
L
L
 
V
I
 
I
G
 
G
L
 
I
S
 
A
A
 
A
A
 
R
D
 
N
A
 
-
D
 
N
S
 
E
H
 
H
I
 
I
G
 
Q
A
 
V
I
 
I
Q
 
T
A
 
S
L
 
L
S
 
T
E
 
N
L
 
A
L
 
L
C
 
D
E
 
D
E
 
E
E
 
S
I
 
V
L
 
I
E
 
E
Q
 
R
L
 
L
L
 
A
T
 
H
A
 
T
S
 
T
S
 
S
E
 
V
K
 
D
Q
 
E
L
 
V
A
 
L
D
 
E
I
 
L
I
 
L
S
 
A

Sites not aligning to the query:

C0H3V2 Mannitol-specific phosphotransferase enzyme IIA component; EIIA; EIII; PTS system mannitol-specific EIIA component from Bacillus subtilis (strain 168) (see paper)
25% identity, 93% coverage: 11:146/147 of query aligns to 8:141/143 of C0H3V2

query
sites
C0H3V2
S
 
N
I
 
I
S
 
K
V
 
L
I
 
N
H
 
Q
S
 
T
A
 
V
K
 
S
D
 
S
W
 
K
Q
 
E
E
 
E
A
 
A
I
 
I
D
 
K
F
 
L
S
 
A
M
 
G
V
 
Q
S
 
T
L
 
L
L
 
I
D
 
D
K
 
N
N
 
G
Y
 
Y
I
 
V
S
 
T
E
 
E
N
 
D
Y
 
Y
I
 
I
Q
 
S
A
 
K
I
 
M
K
 
F
D
 
E
S
 
R
T
 
E
I
 
E
N
 
T
N
 
S
G
 
S
P
 
T
Y
 
F
Y
 
-
I
 
-
L
 
M
A
 
G
P
 
N
G
 
F
V
 
I
A
 
A
M
 
I
P
 
P
H
 
H
A
 
G
R
 
T
P
 
E
E
 
E
C
 
A
G
 
K
A
 
S
-
 
E
-
 
V
L
 
L
K
 
H
T
x
S
G
 
G
M
 
I
S
 
S
L
 
I
T
 
I
L
 
Q
L
 
I
E
 
P
Q
 
E
G
 
G
V
 
V
Y
 
E
F
 
Y
P
 
-
G
 
G
N
 
E
D
 
G
E
 
N
P
 
T
I
 
A
K
 
K
L
 
V
L
 
V
I
 
F
G
 
G
L
 
I
S
 
-
A
 
A
A
 
G
D
 
K
A
 
N
D
 
N
S
 
E
H
 
H
I
 
L
G
 
D
A
 
I
I
 
L
Q
 
S
A
 
N
L
 
I
S
 
A
E
 
I
L
 
I
L
 
C
C
 
S
E
 
E
E
 
E
E
 
E
I
 
N
L
 
I
E
 
E
Q
 
R
L
 
L
L
 
I
T
 
S
A
 
A
S
 
K
S
 
S
E
 
E
K
 
E
Q
 
D
L
 
L
A
 
I
D
 
A
I
 
I
I
 
F
S
 
N
R
 
E

Query Sequence

>17013 FitnessBrowser__Keio:17013
MRLSDYFPESSISVIHSAKDWQEAIDFSMVSLLDKNYISENYIQAIKDSTINNGPYYILA
PGVAMPHARPECGALKTGMSLTLLEQGVYFPGNDEPIKLLIGLSAADADSHIGAIQALSE
LLCEEEILEQLLTASSEKQLADIISRG

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory