Comparing 17036 FitnessBrowser__Keio:17036 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
P00805 L-asparaginase 2; L-asparaginase II; L-ASNase II; L-asparagine amidohydrolase II; Colaspase; EC 3.5.1.1 from Escherichia coli (strain K12) (see 5 papers)
100% identity, 100% coverage: 1:348/348 of query aligns to 1:348/348 of P00805
1ho3A Crystal structure analysis of e. Coli l-asparaginase ii (y25f mutant) (see paper)
100% identity, 94% coverage: 23:348/348 of query aligns to 1:326/326 of 1ho3A
6pa3A E. Coli l-asparaginase ii double mutant (t89v,k162t) in complex with l-asn at ph 7.0 (see paper)
99% identity, 94% coverage: 23:348/348 of query aligns to 9:334/334 of 6pa3A
Sites not aligning to the query:
1jazA Crystal structure of monoclinic form of d90e mutant of escherichia coli asparaginase ii (see paper)
94% identity, 94% coverage: 23:348/348 of query aligns to 1:307/307 of 1jazA
7r5qA Escherichia coli type ii asparaginase n24s mutant in complex with glu (see paper)
94% identity, 94% coverage: 23:348/348 of query aligns to 1:306/306 of 7r5qA
5k45A Wolinella succinogenes l-asparaginase p121 + l-glutamic acid (see paper)
55% identity, 93% coverage: 24:348/348 of query aligns to 2:328/328 of 5k45A
5k3oA Wolinella succinogenes l-asparaginase p121 and l-aspartic acid (see paper)
55% identity, 93% coverage: 24:348/348 of query aligns to 2:328/328 of 5k3oA
2wltA The crystal structure of helicobacter pylori l-asparaginase at 1.4 a resolution (see paper)
50% identity, 94% coverage: 23:348/348 of query aligns to 1:326/326 of 2wltA
6wywA Crystal structure of pseudomonas 7a glutaminase-asparaginase in complex with l-asp at ph 4.5
46% identity, 94% coverage: 23:348/348 of query aligns to 1:317/317 of 6wywA
6wyyA Crystal structure of pseudomonas 7a glutaminase-asparaginase in complex with l-glu at ph 6.5
45% identity, 94% coverage: 23:348/348 of query aligns to 2:315/315 of 6wyyA
P10182 Glutaminase-asparaginase; L-ASNase/L-GLNase; L-asparagine/L-glutamine amidohydrolase; PGA; EC 3.5.1.38 from Pseudomonas sp. (strain ATCC 29598 / 7A) (see paper)
47% identity, 87% coverage: 47:348/348 of query aligns to 34:337/337 of P10182
Sites not aligning to the query:
2gvnA L-asparaginase from erwinia carotovora in complex with aspartic acid (see paper)
49% identity, 94% coverage: 23:348/348 of query aligns to 2:325/325 of 2gvnA
7u6mC Albumin binding domain fused to a mutant of the erwinia asparaginase (see paper)
48% identity, 94% coverage: 23:348/348 of query aligns to 19:342/342 of 7u6mC
P06608 L-asparaginase; L-ASNase; L-asparagine amidohydrolase; EC 3.5.1.1 from Dickeya chrysanthemi (Pectobacterium chrysanthemi) (Erwinia chrysanthemi) (see 2 papers)
48% identity, 95% coverage: 17:348/348 of query aligns to 19:348/348 of P06608
6wyzA Crystal structure of pseudomonas 7a glutaminase-asparaginase (mutant k173m) in complex with d-glu at ph 5.5
45% identity, 94% coverage: 23:348/348 of query aligns to 1:312/312 of 6wyzA
1hg0A X-ray structure of the complex between erwinia chrysanthemi l- asparaginase and succinic acid (see paper)
48% identity, 94% coverage: 23:348/348 of query aligns to 4:327/327 of 1hg0A
1jsrA Crystal structure of erwinia chrysanthemi l-asparaginase complexed with 6-hydroxy-l-norleucine (see paper)
48% identity, 94% coverage: 23:348/348 of query aligns to 1:324/324 of 1jsrA
1jslA Crystal structure of erwinia chrysanthemi l-asparaginase complexed with 6-hydroxy-d-norleucine (see paper)
48% identity, 94% coverage: 23:348/348 of query aligns to 1:324/324 of 1jslA
4pgaA Glutaminase-asparaginase from pseudomonas 7a (see paper)
46% identity, 87% coverage: 47:348/348 of query aligns to 27:330/330 of 4pgaA
Sites not aligning to the query:
1djpA Crystal structure of pseudomonas 7a glutaminase-asparaginase with the inhibitor don covalently bound in the active site (see paper)
46% identity, 87% coverage: 47:348/348 of query aligns to 27:330/330 of 1djpA
Sites not aligning to the query:
>17036 FitnessBrowser__Keio:17036
MEFFKKTALAALVMGFSGAALALPNITILATGGTIAGGGDSATKSNYTVGKVGVENLVNA
VPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYF
LDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGR
DVTKTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVY
NYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKTGTAVVRSSRVPTGAT
TQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory