SitesBLAST
Comparing 17561 FitnessBrowser__Keio:17561 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
P06715 Glutathione reductase; GR; GRase; EC 1.8.1.7 from Escherichia coli (strain K12) (see paper)
100% identity, 100% coverage: 1:450/450 of query aligns to 1:450/450 of P06715
- C42 (= C42) modified: Disulfide link with 47, Redox-active
- C47 (= C47) modified: Disulfide link with 42, Redox-active
1gerB The structure of glutathione reductase from escherichia coli at 1.86 angstroms resolution: comparison with the enzyme from human erythrocytes (see paper)
100% identity, 100% coverage: 2:450/450 of query aligns to 1:449/449 of 1gerB
- active site: L37 (= L38), C41 (= C42), C46 (= C47), K49 (= K50), Y176 (= Y177), E180 (= E181), A436 (= A437), H438 (= H439), E443 (= E444)
- binding flavin-adenine dinucleotide: I9 (= I10), G10 (= G11), G12 (= G13), S13 (= S14), G14 (= G15), E33 (= E34), A34 (= A35), G39 (= G40), T40 (= T41), C41 (= C42), G45 (= G46), C46 (= C47), K49 (= K50), F113 (= F114), A114 (= A115), T138 (= T139), Y176 (= Y177), I177 (= I178), R262 (= R263), G301 (= G302), D302 (= D303), E308 (= E309), L309 (= L310), T310 (= T311)
1getA Anatomy of an engineered NAD-binding site (see paper)
100% identity, 100% coverage: 3:450/450 of query aligns to 1:448/448 of 1getA
- active site: L36 (= L38), C40 (= C42), C45 (= C47), K48 (= K50), Y175 (= Y177), E179 (= E181), A435 (= A437), H437 (= H439), E442 (= E444)
- binding flavin-adenine dinucleotide: I8 (= I10), G9 (= G11), G11 (= G13), S12 (= S14), E32 (= E34), A33 (= A35), G38 (= G40), T39 (= T41), C40 (= C42), G44 (= G46), C45 (= C47), K48 (= K50), F112 (= F114), A113 (= A115), T137 (= T139), I176 (= I178), R261 (= R263), G300 (= G302), D301 (= D303), E307 (= E309), L308 (= L310), T309 (= T311)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: A173 (= A175), G174 (= G176), Y175 (= Y177), I176 (= I178), E179 (= E181), R196 (= R198), R202 (= R204), I259 (= I261), G260 (= G262), E307 (= E309), L308 (= L310), V340 (= V342)
1geuA Anatomy of an engineered NAD-binding site (see paper)
98% identity, 100% coverage: 3:450/450 of query aligns to 1:448/448 of 1geuA
- active site: L36 (= L38), C40 (= C42), C45 (= C47), K48 (= K50), Y175 (= Y177), E179 (= E181), A435 (= A437), H437 (= H439), E442 (= E444)
- binding flavin-adenine dinucleotide: G9 (= G11), G11 (= G13), S12 (= S14), G13 (= G15), E32 (= E34), A33 (= A35), K34 (= K36), G38 (= G40), T39 (= T41), C40 (= C42), G44 (= G46), C45 (= C47), K48 (= K50), F112 (= F114), A113 (= A115), T137 (= T139), G300 (= G302), D301 (= D303), L308 (= L310), T309 (= T311)
- binding nicotinamide-adenine-dinucleotide: Y175 (= Y177), I176 (= I178), E179 (= E181), E195 (≠ V197), M196 (≠ R198), F197 (≠ K199), A258 (= A260), I259 (= I261), G260 (= G262), E307 (= E309), L308 (= L310), V340 (= V342)
5vdnA 1.55 angstrom resolution crystal structure of glutathione reductase from yersinia pestis in complex with fad
85% identity, 100% coverage: 2:450/450 of query aligns to 1:449/449 of 5vdnA
- active site: L37 (= L38), C41 (= C42), C46 (= C47), K49 (= K50), Y176 (= Y177), E180 (= E181), A436 (= A437), H438 (= H439), E443 (= E444)
- binding beta-D-fructopyranose: K35 (= K36), T40 (= T41), G140 (= G141), D157 (= D158)
- binding flavin-adenine dinucleotide: I9 (= I10), G12 (= G13), S13 (= S14), G14 (= G15), E33 (= E34), A34 (= A35), G39 (= G40), T40 (= T41), C41 (= C42), G45 (= G46), C46 (= C47), K49 (= K50), F113 (= F114), A114 (= A115), T138 (= T139), G139 (= G140), Y176 (= Y177), I177 (= I178), R262 (= R263), G301 (= G302), D302 (= D303), E308 (= E309), L309 (= L310), T310 (= T311)
5u1oB 2.3 angstrom resolution crystal structure of glutathione reductase from vibrio parahaemolyticus in complex with fad.
71% identity, 100% coverage: 1:450/450 of query aligns to 1:451/451 of 5u1oB
- active site: L38 (= L38), C42 (= C42), C47 (= C47), K50 (= K50), Y177 (= Y177), E181 (= E181), A438 (= A437), H440 (= H439), E445 (= E444)
- binding flavin-adenine dinucleotide: G13 (= G13), S14 (= S14), G15 (= G15), E34 (= E34), A35 (= A35), T41 (= T41), C42 (= C42), G46 (= G46), C47 (= C47), K50 (= K50), F114 (= F114), A115 (= A115), V139 (≠ T139), Y177 (= Y177), I178 (= I178), R263 (= R263), G302 (= G302), D303 (= D303), E310 (= E309), L311 (= L310), T312 (= T311)
6n7fA 1.90 angstrom resolution crystal structure of glutathione reductase from streptococcus pyogenes in complex with fad.
64% identity, 100% coverage: 1:450/450 of query aligns to 2:451/451 of 6n7fA
- active site: C43 (= C42), C48 (= C47), K51 (= K50), Y178 (= Y177), E182 (= E181), H440 (= H439), E445 (= E444)
- binding flavin-adenine dinucleotide: I11 (= I10), G12 (= G11), G14 (= G13), S15 (= S14), A16 (≠ G15), A34 (≠ I33), E35 (= E34), G36 (≠ A35), K37 (= K36), G41 (= G40), T42 (= T41), C43 (= C42), G47 (= G46), C48 (= C47), K51 (= K50), Y115 (≠ F114), A116 (= A115), T140 (= T139), G141 (= G140), Y178 (= Y177), I179 (= I178), R264 (= R263), G303 (= G302), D304 (= D303), L311 (= L310), T312 (= T311)
- binding riboflavin: G36 (≠ A35), K37 (= K36), Y115 (≠ F114), G270 (≠ N269)
5v36A 1.88 angstrom resolution crystal structure of glutathione reductase from streptococcus mutans ua159 in complex with fad
64% identity, 100% coverage: 1:450/450 of query aligns to 2:451/451 of 5v36A
- active site: V39 (≠ L38), C43 (= C42), C48 (= C47), K51 (= K50), Y178 (= Y177), E182 (= E181), A438 (= A437), H440 (= H439), E445 (= E444)
- binding beta-D-fructopyranose: Y411 (≠ F410), G412 (= G411), D414 (= D413)
- binding flavin-adenine dinucleotide: I11 (= I10), G14 (= G13), S15 (= S14), G16 (= G15), E35 (= E34), G36 (≠ A35), G41 (= G40), T42 (= T41), C43 (= C42), G47 (= G46), C48 (= C47), K51 (= K50), Y115 (≠ F114), A116 (= A115), T140 (= T139), G141 (= G140), Y178 (= Y177), I179 (= I178), R264 (= R263), F271 (≠ I270), G303 (= G302), D304 (= D303), L311 (= L310), T312 (= T311)
6du7A Glutathione reductase from streptococcus pneumoniae (see paper)
61% identity, 100% coverage: 3:450/450 of query aligns to 2:448/448 of 6du7A
- active site: C41 (= C42), C46 (= C47), K49 (= K50), Y176 (= Y177), E180 (= E181), H437 (= H439), E442 (= E444)
- binding flavin-adenine dinucleotide: G10 (= G11), G12 (= G13), S13 (= S14), G14 (= G15), I32 (= I33), E33 (= E34), E34 (≠ A35), G39 (= G40), T40 (= T41), C41 (= C42), G45 (= G46), C46 (= C47), K49 (= K50), H113 (≠ F114), A114 (= A115), T138 (= T139), Y176 (= Y177), R261 (= R263), G300 (= G302), D301 (= D303), L308 (= L310), T309 (= T311)
6b4oA 1.73 angstrom resolution crystal structure of glutathione reductase from enterococcus faecalis in complex with fad
59% identity, 100% coverage: 3:450/450 of query aligns to 4:451/451 of 6b4oA
- active site: I39 (≠ L38), C43 (= C42), C48 (= C47), K51 (= K50), Y178 (= Y177), E182 (= E181), A438 (= A437), H440 (= H439), E445 (= E444)
- binding flavin-adenine dinucleotide: I11 (= I10), G14 (= G13), S15 (= S14), G16 (= G15), E35 (= E34), G36 (≠ A35), G41 (= G40), T42 (= T41), C43 (= C42), G47 (= G46), C48 (= C47), K51 (= K50), Y115 (≠ F114), A116 (= A115), T140 (= T139), G141 (= G140), Y178 (= Y177), I179 (= I178), G303 (= G302), D304 (= D303), D310 (≠ E309), L311 (= L310), T312 (= T311)
5grtA Human glutathione reductase a34e, r37w mutant, glutathionylspermidine complex (see paper)
55% identity, 99% coverage: 5:450/450 of query aligns to 4:461/461 of 5grtA
- active site: L37 (= L38), C41 (= C42), C46 (= C47), K49 (= K50), Y180 (= Y177), E184 (= E181), A448 (= A437), H450 (= H439), E455 (= E444)
- binding flavin-adenine dinucleotide: I9 (= I10), G12 (= G13), G14 (= G15), V32 (≠ I33), E33 (= E34), S34 (≠ A35), G39 (= G40), T40 (= T41), C41 (= C42), G45 (= G46), C46 (= C47), K49 (= K50), H112 (≠ F114), A113 (= A115), T139 (= T139), Y180 (= Y177), G313 (= G302), D314 (= D303), L320 (≠ E309), L321 (= L310), T322 (= T311)
- binding glutathionylspermidine disulfide: S13 (= S14), E17 (≠ A18), C41 (= C42), V42 (= V43), Y89 (= Y91), L93 (≠ I95), I96 (≠ S98), Y97 (= Y99), T322 (= T311), I326 (≠ V315)
4grtA Human glutathione reductase a34e, r37w mutant, mixed disulfide between trypanothione and the enzyme (see paper)
55% identity, 99% coverage: 5:450/450 of query aligns to 4:461/461 of 4grtA
- active site: L37 (= L38), C41 (= C42), C46 (= C47), K49 (= K50), Y180 (= Y177), E184 (= E181), A448 (= A437), H450 (= H439), E455 (= E444)
- binding flavin-adenine dinucleotide: I9 (= I10), G10 (= G11), G11 (= G12), G12 (= G13), S13 (= S14), G14 (= G15), V32 (≠ I33), E33 (= E34), S34 (≠ A35), H35 (≠ K36), G39 (= G40), T40 (= T41), G45 (= G46), C46 (= C47), K49 (= K50), H112 (≠ F114), A113 (= A115), T139 (= T139), G140 (= G140), Y180 (= Y177), G313 (= G302), D314 (= D303), L320 (≠ E309), L321 (= L310), T322 (= T311), A325 (= A314)
- binding bis(gamma-glutamyl-cysteinyl-glycinyl)spermidine: S13 (= S14), L16 (≠ I17), E17 (≠ A18), C41 (= C42), V42 (= V43), V47 (= V48), L93 (≠ I95), Y97 (= Y99), I326 (≠ V315)
3grtA Human glutathione reductase a34e, r37w mutant, oxidized trypanothione complex (see paper)
55% identity, 99% coverage: 5:450/450 of query aligns to 4:461/461 of 3grtA
- active site: L37 (= L38), C41 (= C42), C46 (= C47), K49 (= K50), Y180 (= Y177), E184 (= E181), A448 (= A437), H450 (= H439), E455 (= E444)
- binding flavin-adenine dinucleotide: I9 (= I10), G10 (= G11), G12 (= G13), S13 (= S14), G14 (= G15), V32 (≠ I33), E33 (= E34), S34 (≠ A35), T40 (= T41), C41 (= C42), G45 (= G46), C46 (= C47), K49 (= K50), H112 (≠ F114), A113 (= A115), T139 (= T139), G140 (= G140), Y180 (= Y177), G313 (= G302), D314 (= D303), L321 (= L310), T322 (= T311)
- binding 2-amino-4-[4-(4-amino-4-carboxy-butyrylamino)-5,8,19,22-tetraoxo-1,2-dithia-6,9,13,18,21-pentaaza-cyclotetracos-23-ylcarbamoyl]-butyric acid: S13 (= S14), E17 (≠ A18), W20 (≠ N21), V42 (= V43), L93 (≠ I95), Y97 (= Y99), T322 (= T311), I326 (≠ V315)
2grtA Human glutathione reductase a34e, r37w mutant, oxidized glutathione complex (see paper)
55% identity, 99% coverage: 5:450/450 of query aligns to 4:461/461 of 2grtA
- active site: L37 (= L38), C41 (= C42), C46 (= C47), K49 (= K50), Y180 (= Y177), E184 (= E181), A448 (= A437), H450 (= H439), E455 (= E444)
- binding flavin-adenine dinucleotide: I9 (= I10), G12 (= G13), S13 (= S14), G14 (= G15), E33 (= E34), S34 (≠ A35), G39 (= G40), T40 (= T41), C41 (= C42), V44 (= V45), G45 (= G46), C46 (= C47), K49 (= K50), H112 (≠ F114), A113 (= A115), T139 (= T139), G140 (= G140), Y180 (= Y177), G313 (= G302), D314 (= D303), L321 (= L310), T322 (= T311)
- binding oxidized glutathione disulfide: E17 (≠ A18), W20 (≠ N21), V42 (= V43), L93 (≠ I95), I96 (≠ S98), Y97 (= Y99)
D0VWY5 Glutathione amide reductase; GAR; EC 1.8.1.16 from Marichromatium gracile (Chromatium gracile) (see 2 papers)
52% identity, 100% coverage: 1:450/450 of query aligns to 1:448/463 of D0VWY5
- M1 (= M1) modified: Initiator methionine, Removed
- T2 (= T2) binding
- Q3 (≠ K3) binding
- H4 (= H4) binding
- SG 14:15 (= SG 14:15) binding
- E34 (= E34) binding
- T41 (= T41) binding
- C42 (= C42) modified: Disulfide link with 47, Redox-active
- C47 (= C47) modified: Disulfide link with 42, Redox-active
- K50 (= K50) binding ; binding
- HA 113:114 (≠ FA 114:115) binding
- 174:180 (vs. 175:181, 71% identical) binding
- LE 197:198 (≠ RK 198:199) binding
- V230 (≠ P231) binding
- G261 (= G262) binding
- D302 (= D303) binding
- Q308 (≠ E309) binding
- QLT 308:310 (≠ ELT 309:311) binding
- V341 (= V342) binding
- H437 (= H439) active site, Proton acceptor; binding
Sites not aligning to the query:
- 2:463 modified: mature protein, Glutathione amide reductase
2r9zB Glutathione amide reductase from chromatium gracile (see paper)
52% identity, 100% coverage: 2:450/450 of query aligns to 1:446/453 of 2r9zB
- active site: S13 (= S14), L37 (= L38), C41 (= C42), C46 (= C47), K49 (= K50), G74 (≠ N77), Y174 (= Y177), E178 (= E181), I312 (≠ V315), A433 (= A437), H435 (= H439), E440 (= E444)
- binding flavin-adenine dinucleotide: G12 (= G13), S13 (= S14), G14 (= G15), I32 (= I33), E33 (= E34), S34 (≠ A35), G39 (= G40), T40 (= T41), C41 (= C42), G45 (= G46), C46 (= C47), K49 (= K50), H111 (≠ F114), A112 (= A115), T136 (= T139), G137 (= G140), I175 (= I178), R260 (= R263), G299 (= G302), D300 (= D303), Q306 (≠ E309), L307 (= L310), T308 (= T311)
2rabA Structure of glutathione amide reductase from chromatium gracile in complex with NAD (see paper)
52% identity, 100% coverage: 2:450/450 of query aligns to 1:444/451 of 2rabA
- active site: S13 (= S14), L37 (= L38), C41 (= C42), C46 (= C47), K49 (= K50), Y173 (= Y177), E177 (= E181), I310 (≠ V315), A431 (= A437), H433 (= H439), E438 (= E444)
- binding flavin-adenine dinucleotide: G10 (= G11), G12 (= G13), S13 (= S14), G14 (= G15), I32 (= I33), E33 (= E34), S34 (≠ A35), T40 (= T41), G45 (= G46), C46 (= C47), K49 (= K50), H110 (≠ F114), A111 (= A115), T135 (= T139), G136 (= G140), R258 (= R263), G297 (= G302), D298 (= D303), Q304 (≠ E309), L305 (= L310), T306 (= T311)
- binding nicotinamide-adenine-dinucleotide: K49 (= K50), I169 (≠ V173), G172 (= G176), Y173 (= Y177), I174 (= I178), E177 (= E181), A193 (≠ V197), L194 (≠ R198), E195 (≠ K199), V227 (≠ P231), V256 (≠ I261), G257 (= G262), Q304 (≠ E309), V337 (= V342)
P00390 Glutathione reductase, mitochondrial; GR; GRase; EC 1.8.1.7 from Homo sapiens (Human) (see 2 papers)
55% identity, 99% coverage: 5:450/450 of query aligns to 65:522/522 of P00390
- C102 (= C42) modified: Disulfide link with 107, Redox-active
- C107 (= C47) modified: Disulfide link with 102, Redox-active
- C134 (≠ T75) modified: Interchain
- R153 (= R94) to C: in dbSNP:rs8190955
- G232 (≠ E168) to S: in dbSNP:rs8190976
- I261 (≠ V197) to V: in dbSNP:rs8190997
- E297 (≠ A233) to D: in dbSNP:rs8191004
- G374 (= G302) to A: in HAGRD; decreased glutathione reductase activity; decreased enzyme stability; dbSNP:rs1586033745
4gr1A The binding of the retro-analogue of glutathione disulfide to glutathione reductase (see paper)
55% identity, 99% coverage: 5:450/450 of query aligns to 4:461/461 of 4gr1A
- active site: L37 (= L38), C41 (= C42), C46 (= C47), K49 (= K50), Y180 (= Y177), E184 (= E181), A448 (= A437), H450 (= H439), E455 (= E444)
- binding flavin-adenine dinucleotide: G12 (= G13), S13 (= S14), G14 (= G15), E33 (= E34), S34 (≠ A35), G39 (= G40), T40 (= T41), C41 (= C42), G45 (= G46), C46 (= C47), K49 (= K50), H112 (≠ F114), A113 (= A115), T139 (= T139), G140 (= G140), Y180 (= Y177), G313 (= G302), D314 (= D303), L321 (= L310), T322 (= T311)
- binding 4n-malonyl-cysteinyl-2,4-diaminobutyrate disulfide: L93 (≠ I95), Y97 (= Y99), R330 (= R319)
3sqpA Structure of human glutathione reductase complexed with pyocyanin, an agent with antimalarial activity (see paper)
55% identity, 99% coverage: 5:450/450 of query aligns to 4:461/461 of 3sqpA
- active site: L37 (= L38), C41 (= C42), C46 (= C47), K49 (= K50), Y180 (= Y177), E184 (= E181), A448 (= A437), H450 (= H439), E455 (= E444)
- binding 5-methylphenazin-1(5H)-one: V57 (≠ Q58), V57 (≠ Q58), H58 (≠ I59), F61 (≠ A62), F61 (≠ A62)
- binding flavin-adenine dinucleotide: G10 (= G11), G12 (= G13), S13 (= S14), G14 (= G15), E33 (= E34), S34 (≠ A35), T40 (= T41), C41 (= C42), G45 (= G46), C46 (= C47), K49 (= K50), H112 (≠ F114), A113 (= A115), T139 (= T139), Y180 (= Y177), R274 (= R263), G313 (= G302), D314 (= D303), L320 (≠ E309), L321 (= L310), T322 (= T311), P323 (= P312)
Query Sequence
>17561 FitnessBrowser__Keio:17561
MTKHYDYIAIGGGSGGIASINRAAMYGQKCALIEAKELGGTCVNVGCVPKKVMWHAAQIR
EAIHMYGPDYGFDTTINKFNWETLIASRTAYIDRIHTSYENVLGKNNVDVIKGFARFVDA
KTLEVNGETITADHILIATGGRPSHPDIPGVEYGIDSDGFFALPALPERVAVVGAGYIAV
ELAGVINGLGAKTHLFVRKHAPLRSFDPMISETLVEVMNAEGPQLHTNAIPKAVVKNTDG
SLTLELEDGRSETVDCLIWAIGREPANDNINLEAAGVKTNEKGYIVVDKYQNTNIEGIYA
VGDNTGAVELTPVAVAAGRRLSERLFNNKPDEHLDYSNIPTVVFSHPPIGTVGLTEPQAR
EQYGDDQVKVYKSSFTAMYTAVTTHRQPCRMKLVCVGSEEKIVGIHGIGFGMDEMLQGFA
VALKMGATKKDFDNTVAIHPTAAEEFVTMR
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory